JCI - Citations to Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.

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Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.

B Schnyder, … , F Bettens, W J Pichler

B Schnyder, … , F Bettens, W J Pichler

Published July 1, 1997
Citation Information: J Clin Invest. 1997;100(1):136-141. https://doi.org/10.1172/JCI119505.

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Risk Assessment in Drug Hypersensitivity: Detecting Small Molecules Which Outsmart the Immune System W Pichler, S Watkins, D Yerly		2022
A low-cost, sensitive and specific PCR-based tool for rapid clinical detection of HLA-B*35 alleles associated with delayed drug hypersensitivity reactions. Li Y, Deshpande P, Chopra A, Choo L, Gibson A, Phillips EJ	HLA	2022
Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice M Villanueva-Paz, L Morán, N López-Alcántara, C Freixo, RJ Andrade, MI Lucena, FJ Cubero	Antioxidants	2021
The important role of non‐covalent drug‐protein interactions in drug hypersensitivity reactions WJ Pichler	Allergy	2021
Drug hapten‐specific T‐cell activation: Current status and unanswered questions K Adair, X Meng, DJ Naisbitt	PROTEOMICS	2021
Drug Reaction with Eosinophilia and Systemic Symptoms: A Complex Interplay between Drug, T Cells, and Herpesviridae L Ganeshanandan, M Lucas	International journal of molecular sciences	2021
Current Perspective Regarding the Immunopathogenesis of Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS/DRESS) F Miyagawa, H Asada	International journal of molecular sciences	2021
Genomic Risk Factors Driving Immune-Mediated Delayed Drug Hypersensitivity Reactions Y Li, P Deshpande, RJ Hertzman, AM Palubinsky, A Gibson, EJ Phillips	Frontiers in Genetics	2021
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Adverse Drug Reactions J Uetrecht		2009
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SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactome L Yang, H Luo, J Chen, Q Xing, L He	Nucleic Acids Research	2009
Mechanisms of drug-induced allergy B Schnyder, WJ Pichler	Mayo Clinic proceedings. Mayo Clinic	2009
Role of T cells in nonimmediate allergic drug reactions A Rozieres, M Vocanson, BB Saïd, A Nosbaum, JF Nicolas	Current Opinion in Allergy and Clinical Immunology	2009
Middleton's Allergy: Principles and Practice RP Schleimer	Middleton's Allergy: Principles and Practice	2009
Role of T cells in nonimmediate allergic drug reactions: A Rozieres, M Vocanson, BB Saïd, A Nosbaum, JF Nicolas	Current Opinion in Allergy and Clinical Immunology	2009
Mechanisms of Drug-Induced Allergy B Schnyder, WJ Pichler	Mayo Clinic Proceedings	2009
Immune mediation of hypersensitivity adverse drug reactions: implications for therapy MJ Rieder	Expert Opinion on Drug Safety	2009
Harvesting Candidate Genes Responsible for Serious Adverse Drug Reactions from a Chemical-Protein Interactome L Yang, J Chen, L He, RB Altman	PLoS computational biology	2009
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Allergy Frontiers: Diagnosis and Health Economics R Pawankar, ST Holgate, LJ Rosenwasser		2009
The p-i Concept: Pharmacological Interaction of Drugs With Immune Receptors WJ Pichler	World Allergy Organization Journal	2008
Reactivity of in vitro activated human T lymphocytes to p-phenylenediamine and related substances C Skazik, S Grannemann, L Wilbers, HF Merk, PJ Coenraads, S Breuer, B Blömeke	Contact Dermatitis	2008
The roles of drug metabolism in the pathogenesis of T-cell-mediated drug hypersensitivity SN Lavergne, BK Park, DJ Naisbitt	Current Opinion in Allergy and Clinical Immunology	2008
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Immunological principles of T-cell-mediated adverse drug reactions in skin DJ Naisbitt, M Pirmohamed, BK Park	Expert Opinion on Drug Safety	2007
Human leukocyte antigens and drug hypersensitivity WH Chung, SI Hung, YT Chen	Current Opinion in Allergy and Clinical Immunology	2007
Drug hypersensitivity reactions in patients with HIV disease M Pirmohamed, NS Drummond, DJ Naisbitt, BK Park	Expert Review of Clinical Immunology	2007
HLA-B∗1502–bound peptides: Implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome CW Yang, SI Hung, CG Juo, YP Lin, WH Fang, IH Lu, ST Chen, YT Chen	Journal of Allergy and Clinical Immunology	2007
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Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions BO Gerber, WJ Pichler	The AAPS Journal	2006
Immune Mechanisms in Drug Allergy JC Roujeau	Allergology International	2006
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions SI Hung, WH Chung, SH Jee, WC Chen, YT Chang, WR Lee, SL Hu, MT Wu, GS Chen, TW Wong, PF Hsiao, WH Chen, HY Shih, WH Fang, CY Wei, YH Lou, YL Huang, JJ Lin, YT Chen	Pharmacogenetics and Genomics	2006
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Mechanisms of drug-induced delayed-type hypersensitivity reactions in the skin S Roychowdhury, CK Svensson	The AAPS Journal	2005
Histopathology of drug-induced exanthems: is there a role in diagnosis of drug allergy? M Brönnimann, N Yawalkar	Current Opinion in Allergy and Clinical Immunology	2005
HLA-Bgenotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine SI Hung, WH Chung, YT Chen	Personalized Medicine	2005
Histopathology of drug-induced exanthems: is there a role in diagnosis of drug allergy?: M Brönnimann, N Yawalkar	Current Opinion in Allergy and Clinical Immunology	2005
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Characterization of the Formation and Localization of Sulfamethoxazole and Dapsone-Associated Drug-Protein Adducts in Human Epidermal Keratinocytes S Roychowdhury, PM Vyas, TP Reilly, AA Gaspari, CK Svensson	The Journal of pharmacology and experimental therapeutics	2005
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Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests DJ Naisbitt	Toxicology	2004
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Drug-Induced Hypersensitivity HV Ratajczak	Toxicological Reviews	2004
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Molecular pathways in dermatotoxicology HF Merk, J Abel, JM Baron, J Krutmann	Toxicology and Applied Pharmacology	2004
Drug-Induced Hypersensitivity: Role in Drug Development HV Ratajczak	Toxicological Reviews	2004
Immune mechanism of drug hypersensitivity WJ Pichler	Immunology and Allergy Clinics of North America	2004
Not All Sulfa Drugs Are Created Equal SM Toler, I Rodriguez	The Annals of pharmacotherapy	2004
Clinical Pharmacology: Special Safety Considerations in Drug Development and Pharmacovigilance KN Atuah, D Hughes, M Pirmohamed	Drug Safety	2004
Gene polymorphisms within the immune system that may underlie drug allergy RJ Vandebriel	Naunyn-Schmiedeberg's Archives of Pharmacology	2004
Lessons from drug allergy: Against dogmata WJ Pichler	Current Allergy and Asthma Reports	2003
Identifier et comprendre les allergies médicamenteuses P Demoly, D Hillaire-Buys, N Raison-Peyron, P Godard, FB Michel, J Bousquet	médecine/sciences	2003
Hypersensitivity Reactions to Carbamazepine: Characterization of the Specificity, Phenotype, and Cytokine Profile of Drug-Specific T Cell Clones DJ Naisbitt, M Britschgi, G Wong, J Farrell, JP Depta, DW Chadwick, WJ Pichler, M Pirmohamed, BK Park	Molecular pharmacology	2003
Mechanisms in cutaneous drug hypersensitivity reactions PS Friedmann, MS Lee, AC Friedmann, RS Barnetson	Clinical & Experimental Allergy	2003
Characterization of drug-specific T cells in lamotrigine hypersensitivity DJ Naisbitt, J Farrell, G Wong, JH Depta, CC Dodd, JE Hopkins, CA Gibney, DW Chadwick, WJ Pichler, M Pirmohamed, BK Park	Journal of Allergy and Clinical Immunology	2003
Drug-induced autoimmunity: WJ Pichler	Current Opinion in Allergy and Clinical Immunology	2003
Cross-reactivity with drugs at the T cell level: JP Depta, WJ Pichler	Current Opinion in Allergy and Clinical Immunology	2003
Characterization of Sulfamethoxazole and Sulfamethoxazole Metabolite-Specific T-Cell Responses in Animals and Humans J Farrell, DJ Naisbitt, NS Drummond, JP Depta, FJ Vilar, M Pirmohamed, BK Park	The Journal of pharmacology and experimental therapeutics	2003
Do Arylhydroxylamine Metabolites Mediate Idiosyncratic Reactions Associated with Sulfonamides? CK Svensson	Chemical Research in Toxicology	2003
Drug Specific Cytotoxic T-Cells in the Skin Lesions of a Patient with Toxic Epidermal Necrolysis A Nassif, A Bensussan, G Dorothee, F Mami-Chouaib, N Bachot, M Bagot, L Boumsell, JC Roujeau	Journal of Investigative Dermatology	2002
Cellular and Molecular Pathophysiology of Cutaneous Drug Reactions: WJ Pichler, N Yawalkar, M Britschgi, J Depta, I Strasser, S Schmid, P Kuechler, D Naisbitt	American Journal of Clinical Dermatology	2002
T cells in drug allergy WJ Pichler	Current Allergy and Asthma Reports	2002
Allergic adverse reactions to sulfonamides G Choquet-Kastylevsky, T Vial, J Descotes	Current Allergy and Asthma Reports	2002
Non-covalent presentation of sulfamethoxazole to human CD4+T cells is independent of distinct human leucocyte antigen-bound peptides C Burkhart, M Britschgi, I Strasser, JP Depta, S Greyerz, V Barnaba, WJ Pichler	Clinical & Experimental Allergy	2002
Gene Expression Levels of Cytokine Profile and Cytotoxic Markers in Non-Immediate Reactions to Drugs SJ Posadas, MJ Torres, C Mayorga, C Juarez, M Blanca	Blood Cells, Molecules, and Diseases	2002
Deciphering the immune pathomechanism of cutaneous drug reactions WJ Pichler	Allergy	2002
Pathogenesis of drug-induced exanthems W Pichler, N Yawalkar, S Schmid, A Helbling	Allergy	2002
The danger hypothesis—potential role in idiosyncratic drug reactions M Pirmohamed, DJ Naisbitt, F Gordon, BK Park	Toxicology	2002
Modes of presentation of chemical neoantigens to the immune system WJ Pichler	Toxicology	2002
Mechanistic perspectives on sulfonamide-induced cutaneous drug reactions: TP Reilly, C Ju	Current Opinion in Allergy and Clinical Immunology	2002
Non-covalent presentation of sulfamethoxazole to human CD4 + T cells is independent of distinct human leucocyte antigen-bound peptides C Burkhart, M Britschgi, I Strasser, JP Depta, S Greyerz, V Barnaba, WJ Pichler	Clinical & Experimental Allergy	2002
Delayed-type hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific αβ+ human T-cell clones S Sieben, Y Kawakubo, TA Masaoudi, HF Merk, B Blömeke	Journal of Allergy and Clinical Immunology	2002
Pharmacological interaction of drugs with antigen-specific immune receptors: the p-i concept: WJ Pichler	Current Opinion in Allergy and Clinical Immunology	2002
Characterization of Drug-Specific T Cells in Phenobarbital- Induced Eruption H Hashizume, M Takigawa, Y Tokura	Journal of immunology (Baltimore, Md. : 1950)	2002
Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation DJ Naisbitt, J Farrell, SF Gordon, JL Maggs, C Burkhart, WJ Pichler, M Pirmohamed, BK Park	Molecular pharmacology	2002
Cytotoxic HIV-1 p55gag-specific CD4+ T cells produce HIV-inhibitory cytokines and chemokines Barbara Lotti, Thomas Wendland, Hansjakob Furrer, Nikhil Yawalkar, Salome von Greyerz, Karin Schnyder, Marlène Brandes, Pietro Vernazza, Ralf Wagner, Thi Nguyen, Eric Rosenberg, Werner J Pichler, Christian Brander	Journal of Clinical Immunology	2002
T cell involvement in drug-induced acute generalized exanthematous pustulosis Markus Britschgi, Urs C. Steiner, Simone Schmid, Jan P.H. Depta, Gabriela Senti, Andreas Bircher, Christoph Burkhart, Nikhil Yawalkar, and Werner J. Pichler	Journal of Clinical Investigation	2001
Metabolic activation in drug allergies BK Park, DJ Naisbitt, SF Gordon, NR Kitteringham, M Pirmohamed	Toxicology	2001
Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo DJ Naisbitt, SF Gordon, M Pirmohamed, C Burkhart, AE Cribb, WJ Pichler, BK Park	British Journal of Pharmacology	2001
Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells C Burkhart, S Greyerz, JP Depta, DJ Naisbitt, M Britschgi, KB Park, WJ Pichler	British Journal of Pharmacology	2001
Induction of delayed-type hypersensitivity to sulfamethoxazole in mice: role of metabolites G Choquet-Kastylevsky, N Santolaria, R Tedone, M Aujoulat, J Descotes	Toxicology Letters	2001
T cell involvement in cutaneous drug eruptions Y Hari, K Frutig-Schnyder, M Hurni, N Yawalkar, MP Zanni, B Schnyder, A Kappeler, SV Greyerz, LR Braathen, WJ Pichler	Clinical & Experimental Allergy	2001
Drug metabolism, danger signals, and drug-induced hypersensitivity RS Gruchalla	Journal of Allergy and Clinical Immunology	2001
NEW ADVANCES IN SEVERE ADVERSE DRUG RESCTIONS J Revuz	Dermatologic Clinics	2001
Hypersensitivity adverse drug reactions in children: Pathophysiology and therapeutic implications MJ Rieder	Current Therapeutic Research	2001
Characterization of T Cell Responses to Fragrances S Sieben, M Hertl, TA Masaoudi, HF Merk, B Blömeke	Toxicology and Applied Pharmacology	2001
Immunohistology of drug-induced exanthema: clues to pathogenesis: N Yawalkar, WJ Pichler	Current Opinion in Allergy and Clinical Immunology	2001
Reactive metabolites and their role in drug reactions: DJ Naisbitt, DP Williams, M Pirmohamed, NR Kitteringham, BK Park	Current Opinion in Allergy and Clinical Immunology	2001
HIV and drug allergy: M Pirmohamed, BK Park	Current Opinion in Allergy and Clinical Immunology	2001
Drug allergy: WJ Pichler	Current Opinion in Allergy and Clinical Immunology	2001
Degeneracy and additional alloreactivity of drug-specific human αβ+ T cell clones S Greyerz, G Bültemann, K Schnyder, C Burkhart, B Lotti, Y Hari, WJ Pichler	International Immunology	2001
Predictive drug allergy testing: an alternative viewpoint WJ Pichler	Toxicology	2001
Advances in molecular toxicology–towards understanding idiosyncratic drug toxicity BK Park, NR Kitteringham, H Powell, M Pirmohamed	Toxicology	2000
Allergic reactions to drugs: involvement of T cells WJ Pichler, N Yawalkar	Thorax	2000
Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors LL Cleach, S Delaire, L Boumsell, M Bagot, I Bourgault-Villada, A Bensussan, JC Roujeau	Clinical & Experimental Immunology	2000
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity M Pirmohamed, A Alfirevic, J Vilar, A Stalford, EG Wilkins, E Sim, BK Park	Pharmacogenetics	2000
T Cells Isolated from Positive Epicutaneous Test Reactions to Amoxicillin and Ceftriaxone are Drug Specific and Cytotoxic N Yawalkar, Y Hari, K Frutig, F Egli, T Wendland, LR Braathen, WJ Pichler	Journal of Investigative Dermatology	2000
Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity: M Pirmohamed, A Alfirevic, J Vilar, A Stalford, EG Wilkins, E Sim, BK Park	Pharmacogenetics	2000
Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions Yawalkar, Egli, Hari, Nievergelt, Braathen, Pichler	Clinical & Experimental Allergy	2000
Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction SJ Posadas, L Leyva, MJ Torres, JL Rodriguez, I Bravo, M Rosal, J Fernandez, C Juarez, M Blanca	Journal of Allergy and Clinical Immunology	2000
Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions N Yawalkar, M Shrikhande, Y Hari, H Nievergelt, LR Braathen, WJ Pichler	Journal of Allergy and Clinical Immunology	2000
Il-4 and IFN-gamma mRNA induction in human peripheral lymphocytes specific for beta-lactam antibiotics in immediate or delayed hypersensitivity reactions I Gaspard, MT Guinnepain, J Laurent, N Bachot, S Kerdine, J Bertoglio, M Pallardy, H Lebrec	Journal of Clinical Immunology	2000
Immunological Principles of Adverse Drug Reactions: The Initiation and Propagation of Immune Responses Elicited by Drug Treatment DJ Naisbitt, S Gordon, M Pirmohamed, B Park	Drug Safety	2000
Recognition of Sulfamethoxazole and Its Reactive Metabolites by Drug-Specific CD4 + T Cells from Allergic Individuals B Schnyder, C Burkhart, K Schnyder-Frutig, S von Greyerz, DJ Naisbitt, M Pirmohamed, BK Park, WJ Pichler	Journal of immunology (Baltimore, Md. : 1950)	2000
Molecular mechanisms of CD8+ T cell–mediated delayed hypersensitivity: Implications for allergies, asthma, and autoimmunity RS Kalish, PW Askenase	Journal of Allergy and Clinical Immunology	1999
Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity DJ Naisbitt, SJ Hough, HJ Gill, M Pirmohamed, NR Kitteringham, BK Park	British Journal of Pharmacology	1999
Recognition of Local Anesthetics by alphabeta+ T Cells MP Zanni, S Greyerz, Y Hari, B Schnyder, WJ Pichler	Journal of Investigative Dermatology	1999
T-cell reaction to local anaesthetics: relationship to angioedema and urticaria after subcutaneous application - patch testing and LTT in patients with adverse reaction to local anaesthetics Orasch, Helbling, Zanni, Yawalkar, Hari, Pichler	Clinical & Experimental Allergy	1999
HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes MP Zanni, S Greyerz, B Schnyder, KA Brander, K Frutig, Y Hari, S Valitutti, WJ Pichler	Journal of Clinical Investigation	1998
Role of T cells in drug allergies WJ Pichler, B Schnyder, MP Zanni, Y Hari, S Greyerz	Allergy	1998
Involvement of T cells in drug-induced allergies MP Zanni, B Schnyder, S Greyerz, WJ Pichler	Trends in Pharmacological Sciences	1998
CD8+ T cells in atopic disease DM Kemeny	Current Opinion in Immunology	1998
T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazol-induced skin reaction Schnyder, Frutig, Mauri-Hellweg, Limat, Yawalkar, Pichler	Clinical & Experimental Allergy	1998
SULFONAMIDE ALLERGY A Montanaro	Immunology and Allergy Clinics of North America	1998
Mechanisms of drug allergy JW Coleman, M Blanca	Immunology Today	1998
Allergic and autoimmune reactions to xenobiotics: how do they arise? P Griem, M Wulferink, B Sachs, JB González, E Gleichmann	Immunology Today	1998
Désensibilisation et accoutumance médicamenteuse chez le sujet VIH P Demoly, D Messaad, H Sahla, P Godard, FB Michel, J Bousquet	Revue Française d'Allergologie et d'Immunologie Clinique	1998
Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective BK Park, M Pirmohamed, NR Kitteringham	Chemical Research in Toxicology	1998
Allergy to antibacterials: the problem with beta-lactams and sulfonamides: Allergy to antibacterials A Cerny, W Pichler	Pharmacoepidemiology and Drug Safety	1998
Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils BO Gerber, MP Zanni, M Uguccioni, M Loetscher, CR Mackay, WJ Pichler, N Yawalkar, M Baggiolini, B Moser	Current Biology	1997
Drug allergy: relationship between immunogenicity and clinical symptoms WJ Pichler	Allergy	1996

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