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Abstract
Diabetic nephropathy is a glomerular disease due to uncontrolled diabetes and genetic factors. It can be caused by glomerular hypertension produced by capillary vasodilation, due to diabetes, against constitutional glomerular resistance. As angiotensin II increases glomerular pressure, we studied the relationship between genetic polymorphisms in the renin-angiotensin system-angiotensin I converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II, subtype 1, receptor-and the renal involvement of insulin-dependent diabetic subjects with proliferative retinopathy: those exposed to the risk of nephropathy due to diabetes. Of 494 subjects recruited in 17 centers in France and Belgium (GENEDIAB Study), 157 (32%) had no nephropathy, 104 (21%) incipient (microalbuminuria), 126 (25 %) established (proteinuria), and 107 (22%) advanced (plasma creatinine > or = 150 micromol/liter or renal replacement therapy) nephropathy. The severity of renal involvement was associated with ACE insertion/deletion (I/D) polymorphism: chi2 for trend 5.135, P = 0.023; adjusted odds ratio attributable to the D allele 1.889 (95% CI 1.209-2.952, P = 0.0052). Renal involvement was not directly linked to other polymorphisms. However, ACE I-D and AGT M235T polymorphisms interacted significantly (P = 0.0166): in subjects with ACE ID and DD genotypes, renal involvement increased from the AGT MM to TT genotypes. Thus, genetic determinants that affect renal angiotensin II and kinin productions are risk factors for the progression of glomerular disease in uncontrolled insulin-dependent diabetic patients.
Authors
M Marre, X Jeunemaitre, Y Gallois, M Rodier, G Chatellier, C Sert, L Dusselier, Z Kahal, L Chaillous, S Halimi, A Muller, H Sackmann, B Bauduceau, F Bled, P Passa, F Alhenc-Gelas
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Polymorphisms of the Renin-Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis
A Kretowski, K McFann, JE Hokanson, D Maahs, G Kinney, JK Snell-Bergeon, RP Wadwa, RH Eckel, L Ogden, S Garg, J Li, S Cheng, HA Erlich, M Rewers |
Diabetes | 2007 |
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Renin–angiotensin system gene polymorphisms: association with susceptibility to Henoch–Schonlein purpura and renal involvement
O Özkaya, O Söylemezoğlu, S Gönen, M Mısırlıoğlu, S Tuncer, S Kalman, N Buyan, E Hasanoğlu |
Clinical Rheumatology | 2006 |
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Combinational effect of genes for the renin–angiotensin system in conferring susceptibility to diabetic nephropathy
N Osawa, D Koya, S Araki, T Uzu, T Tsunoda, A Kashiwagi, Y Nakamura, S Maeda |
Journal of Human Genetics | 2006 |
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Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms
P Prasad, AK Tiwari, KM Kumar, AC Ammini, A Gupta, R Gupta, AK Sharma, AR Rao, R Nagendra, TS Chandra, SC Tiwari, P Rastogi, BL Gupta, BK Thelma |
BMC Medical Genetics | 2006 |
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The relationship between genetic and haemodynamic factors in diabetic nephropathy (DN): Case–control study in type 1 diabetes mellitus (T1DM)
MV Shestakova, OK Vikulova, NM Gorashko, OE Voronko, NB Babunova, VV Nosikov, II Dedov |
Diabetes Research and Clinical Practice | 2006 |
|
Type 1 Diabetes and Coronary Artery Disease
TJ Orchard, T Costacou, A Kretowski, RW Nesto |
Diabetes care | 2006 |
|
Analysis of 14 Candidate Genes for Diabetic Nephropathy on Chromosome 3q in European Populations: Strongest Evidence for Association With a Variant in the Promoter Region of the Adiponectin Gene
N Vionnet, D Tregouet, G Kazeem, I Gut, PH Groop, L Tarnow, HH Parving, S Hadjadj, C Forsblom, M Farrall, D Gauguier, R Cox, F Matsuda, S Heath, A Thevard, R Rousseau, F Cambien, M Marre, M Lathrop |
Diabetes | 2006 |
|
Are the angiotensin-converting enzime gene and acticity risk factors for stroke?
M Dikmen, HV Günes, I Degirmenci, G Özdemir, A Basaran |
Arquivos de Neuro-Psiquiatria | 2006 |
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Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects
DP Ng, BC Tai, D Koh, KW Tan, KS Chia |
Diabetologia | 2005 |
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ACE I/D polymorphism is associated with mortality in a cohort study of patients starting with dialysis
FV der Beer, C Verhagen, SM Rombach, P Boorsma, JG van Manen, JC Korevaar, RV Bogaard, EW Boeschoten, RT Krediet, GJ Navis, JP Vandenbroucke, FW Dekker |
Kidney International | 2005 |
|
The Kallikrein-Kinin System: Current and Future Pharmacological Targets
ME Moreau, N Garbacki, G Molinaro, NJ Brown, F Marceau, A Adam |
Journal of Pharmacological Sciences | 2005 |
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Polymorphisms of the insertion / deletion ACE and M235T AGT genes and hypertension: surprising new findings and meta-analysis of data
A Mondry, M Loh, P Liu, AL Zhu, M Nagel |
BMC Nephrology | 2005 |
|
ACE and non-ACE pathways in the renal vascular response to RAS interruption in type 1 diabetes mellitus
MC Lansang, R Stevanovic, DA Price, LM Laffel, NK Hollenberg |
Kidney International | 2005 |
|
Renin–angiotensin system polymorphisms interact with blood pressure in the determination of microalbuminuria in the general population
SM Titan, AC Pereira, RS Cunha, FL Herkenhoff, JG Mill, JE Krieger |
Journal of Human Hypertension | 2005 |
|
Hipercolesterolemia y nefropatía diabética, una asociación multifactorial
I Salinas, R Romero |
Medicina Clínica | 2005 |
|
Frequency of angiotensin-converting enzyme gene polymorphism in Turkish type 2 diabetic patients
I Degirmenci, N Kebapci, A Basaran, B Efe, HV Gunes, A Akalin, H Kurt, M Urhan, C Demirustu |
International Journal of Clinical Practice | 2005 |
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Polymorphisms of the Receptor of Advanced Glycation Endproducts (RAGE) and the development of nephropathy in type 1 diabetic patients
G Prevost, I Fajardy, C Besmond, B Balkau, J Tichet, P Fontaine, PM Danze, M Marre |
Diabetes & Metabolism | 2005 |
|
Predicting the development of diabetic nephropathy and its progression
J William, D Hogan, D Batlle |
Advances in Chronic Kidney Disease | 2005 |
|
Modulation of the Renal Response to ACE Inhibition by ACE Insertion/Deletion Polymorphism During Hyperglycemia in Normotensive, Normoalbuminuric Type 1 Diabetic Patients
L Weekers, B Bouhanick, S Hadjadj, Y Gallois, R Roussel, F Pean, A Ankotche, G Chatellier, F Alhenc-Gelas, PJ Lefebvre, M Marre |
Diabetes | 2005 |
|
Assessment of 115 Candidate Genes for Diabetic Nephropathy by Transmission/Disequilibrium Test
KG Ewens, RA George, K Sharma, FN Ziyadeh, RS Spielman |
Diabetes | 2005 |
|
Genetic Variation at the ACE Gene Is Associated With Persistent Microalbuminuria and Severe Nephropathy in Type 1 Diabetes: The DCCT/EDIC Genetics Study
AP Boright, AD Paterson, L Mirea, SB Bull, A Mowjoodi, SW Scherer, B Zinman |
Diabetes | 2005 |
|
Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction
Mahmoud Suleiman, Doron Aronson, Rabea Asleh, Michael R Kapeliovich, Ariel Roguin, Simcha R Meisel, Michael Shochat, Abeer Sulieman, Shimon A Reisner, Walter Markiewicz, Haim Hammerman, Rachel Lotan, Nina S Levy, Andrew P Levy |
Diabetes | 2005 |
|
Preventing end stage renal disease in diabetic patients — genetic aspect (part I)
PK Jacobsen |
Journal of Renin-Angiotensin-Aldosterone System | 2005 |
|
Effects of Genetic Polymorphisms of the Renin-Angiotensin System in Children with Nephrotic Syndrome
Y Tabel, A Berdeli, S Mir, E Serdaroğlu, E Ytlmaz |
Journal of Renin-Angiotensin-Aldosterone System | 2005 |
|
Polymorphisms of the renin-angiotensin system genes in Brazilian patients with lupus nephropathy
SR Sprovieri, YA Sens |
Lupus | 2005 |
|
Which Comes First—Renal Dysfunction or High Blood Pressure?: Elevated Blood Pressure and Risk of End-Stage Renal Disease in Subjects without Baseline Kidney Disease. Arch Intern Med 165: 923–928, 2005
H CY, MC CE, D J, G AS, I C |
Journal of the American Society of Nephrology : JASN | 2005 |
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Genetic variation at the ACE gene is associated with persistent microalbuminuria and severe nephropathy in type 1 diabetes: the DCCT/EDIC Genetics Study.
Boright AP, Paterson AD, Mirea L, Bull SB, Mowjoodi A, Scherer SW, Zinman B |
Diabetes | 2005 |
|
Angiotensin-converting enzyme polymorphism gene and evolution of nephropathy to end-stage renal disease
MA Ortiz, AD Prado, T Doñate, L Gallart, H Claramunt, M Hernández, J Martínez, E Martínez, JM Pou |
Nephrology (Carlton, Vic.) | 2004 |
|
Système rénine-angiotensine et remodelage vasculaire
JB Michel |
médecine/sciences | 2004 |
|
Association of Angiotensin-Converting Enzyme and Angiotensinogen Gene Polymorphisms with Preeclampsia
H Choi, JY Kang, HS Yoon, SS Han, CS Whang, IG Moon, HH Shin, JB Park |
Journal of Korean Medical Science | 2004 |
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Polymorphism of renin-angiotensin system genes in IgA nephropathy
KT Woo, YK Lau, LH Choong, Y Zhao, HB Tan, S Fook-Chong, EK Tan, HK Yap, KS Wong |
Nephrology | 2004 |
|
Frequency of angiotensin-converting enzyme gene polymorphism in Turkish hypertensive patients
HV Gunes, N Ata, I Degirmenci, A Basaran, B Timuralp, M Dikmen, C Ustuner, G Kudaiberdieva |
International Journal of Clinical Practice | 2004 |
|
Pharmacogenomics and renal drug disposition in the newborn
G Kapur, T Mattoo, JV Aranda |
Seminars in Perinatology | 2004 |
|
Angiotensin-Converting Enzyme and Angiotensin Type 2 Receptor Gene Genotype Distributions in Italian Children with Congenital Uropathies
L Rigoli, R Chimenz, CD Bella, E Cavallaro, R Caruso, S Briuglia, C Fede, CD Salpietro |
Pediatric Research | 2004 |
|
Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus
M Murata, T Maruyama, Y Suzuki, T Saruta, Y Ikeda |
Diabetic Medicine | 2004 |
|
Génétique des complications du diabète : néphropathie
X Jeunemaitre |
Annales d'Endocrinologie | 2004 |
|
Transforming growth factor-beta 1 production is correlated with genetically determined ACE expression in congenic rats: a possible link between ACE genotype and diabetic nephropathy
Maria E Pueyo, Mireille Challah, Dominique Gauguier, Liliane Louedec, Monique Philippe, Roger Gaertner, Michel Marre, Jean-Baptiste Michel, Marie-Paule Jacob |
Diabetes | 2004 |
|
Investigation of the human ANP gene in type 1 diabetic nephropathy: case-control and follow-up studies
Ronan Roussel, David-Alexandre Trégouët, Samy Hadjadj, Xavier Jeunemaître, Michel Marre |
Diabetes | 2004 |
|
Different patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy: the Genesis France-Belgium Study
Samy Hadjadj, Franck Péan, Yves Gallois, Philippe Passa, Robert Aubert, Laurent Weekers, Vincent Rigalleau, Bernard Bauduceau, Amine Bekherraz, Ronan Roussel, Bernard Dussol, Michel Rodier, Richard Marechaud, Pierre J Lefebvre, Michel Marre, |
Diabetes care | 2004 |
|
Glu298Asp Endothelial Nitric Oxide Synthase Polymorphism Is a Risk Factor for Erectile Dysfunction in the Mexican Mestizo Population
H Rosas-Vargas, RM Coral-Vazquez, R Tapia, JL Borja, RA Salas, F Salamanca |
Journal of andrology | 2004 |
|
Conséquences tissulaires de l’activation du système rénine-angiotensine
JB Michel |
Bulletin de l'Académie nationale de médecine | 2004 |
|
Les récepteurs de la bradykinine : de nouveaux rôles physiopathologiques
JL Bascands, JP Schanstra, R Couture, JP Girolami |
médecine/sciences | 2003 |
|
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
|
Angiotensin-Converting Enzyme Gene Polymorphisms in Patients with Pulmonary Sarcoidosis
M Sch??rmann |
American Journal of PharmacoGenomics | 2003 |
|
Pharmacogenomics of diuretic drugs: data on rare monogenic disorders and on polymorphisms and requirements for further research
SV Vormfelde, G Burckhardt, A Zirk, L Wojnowski, J Brockmöller |
Pharmacogenomics | 2003 |
|
Angiotensin-I-converting enzyme insertion/deletion polymorphism and high urinary albumin concentration in French Type 2 diabetes patients
S Hadjadj, Y Gallois, F Alhenc-Gelas, G Chatellier, M Marre |
Diabetic Medicine | 2003 |
|
Diabetic nephropathy—an acquired or inherited disease?
PH Groop, C Forsblom |
International Congress Series | 2003 |
|
DEVELOPMENT OF DIABETES MELLITUS SEVERAL YEARS AFTER MANIFESTATION OF DIABETIC NEPHROPATHY: CASE REPORT AND REVIEW OF LITERATURE
ES MD, JM MD, SN MD, AE FACE, SS FACE |
Endocrine Practice | 2003 |
|
Genetics and diabetic renal disease: still a big black hole
Carl Erik Mogensen |
Diabetes care | 2003 |
|
Pharmacogénétique, étude du génome et développement des médicaments
F Alhenc-Gelas, L Parmentier, A Bisagni |
Thérapie | 2003 |
|
Pharmacogenetic and Pharmacogenomic Studies
F Alhenc-Gelas, L Parmentier, A Bisagni |
Thérapie | 2003 |
|
Genetic Variation in the Renin-Angiotensin System and Progression of Diabetic Nephropathy
P Jacobsen, L Tarnow, B Carstensen, P Hovind, O Poirier, HH Parving |
Journal of the American Society of Nephrology : JASN | 2003 |
|
Absence of Angiotensin II Type 1 Receptor in Bone Marrow-Derived Cells is Detrimental in the Evolution of Renal Fibrosis
Masashi Nishida, Hidehiko Fujinaka, Taiji Matsusaka, James Price, Valentina Kon, Agnes B. Fogo, Jeffrey M. Davidson, MacRae F. Linton, Sergio Fazio, Toshio Homma, Hiroaki Yoshida, Iekuni Ichikawa |
Journal of Clinical Investigation | 2002 |
|
Angiotensin II receptor polymorphisms in hypertension. Pharmacogenomic considerations
B Baudin |
Pharmacogenomics | 2002 |
|
Role of the alpha-adducin genotype on renal disease progression
J Nicod, BM Frey, FJ Frey, P Ferrari |
Kidney International | 2002 |
|
Angiotensin converting enzyme DD genotype is associated with hypertensive crisis*
G Sunder-Plassmann, H Kittler, C Eberle, MM Hirschl, C Woisetschläger, U Derhaschnig, AN Laggner, WH Hörl, M Födinger |
Critical Care Medicine | 2002 |
|
Microalbuminuria in diabetes: Focus on cardiovascular and renal risk reduction
GL Bakris, JR Sowers |
Current Diabetes Reports | 2002 |
|
Bradykinin B2receptor gene polymorphism is associated with altered urinary albumin/creatinine values in diabetic patients
I Maltais, M Bachvarova, P Maheux, P Perron, F Marceau, D Bachvarov |
Canadian Journal of Physiology and Pharmacology | 2002 |
|
ACE and PC-1 gene polymorphisms in normoalbuminuric Type 1 diabetic patients
M Azevedo |
Journal of Diabetes and its Complications | 2002 |
|
Single strand conformation polymorphism (SSCP) as a quick and reliable method to genotype M235T polymorphism of angiotensinogen gene
P Bettinaglio, A Galbusera, J Caprioli, S Orisio, A Perna, F Arnoldi, S Bucchioni, M Noris |
Clinical Biochemistry | 2002 |
|
Prognostic role of serum ACE activity on outcome of type 2 diabetic patients on chronic ambulatory peritoneal dialysis
TY Wong, CC Szeto, KM Chow, JC Chan, PK Li |
American Journal of Kidney Diseases | 2002 |
|
Relevancia de los polimorfismos génicos del sistema renina-angiotensina en la enfermedad coronaria
EH Ortega, AM Fernández-Aceituno, FJ Esparragón, OH Perera, FM Nuez, AD Espinosa, DF Pérez, AA Prieto, JC Pérez |
Revista Española de Cardiología | 2002 |
|
The angiotensin-converting enzyme DD genotype is associated with glomerulopathy lesions in type 2 diabetes
A Solini, MD Vestra, A Saller, R Nosadini, G Crepaldi, P Fioretto |
Diabetes | 2002 |
|
Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE
WS Uhm, HS Lee, YH Chung, TH Kim, SC Bae, KB Joo, TY Kim, DH Yoo |
Lupus | 2002 |
|
AT1-receptor blockade and the kidney: importance of non-ACE pathways in health and disease
NK Hollenberg |
Journal of Human Hypertension | 2002 |
|
Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis
Nishida M, Fujinaka H, Matsusaka T, Price J, Kon V, Fogo AB, Davidson JM, Linton MF, Fazio S, Homma T, Yoshida H, Ichikawa I |
Journal of Clinical Investigation | 2002 |
|
Dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with diabetic nephropathy
S Maeda, M Haneda, B Guo, D Koya, K Hayashi, T Sugimoto, K Isshiki, H Yasuda, A Kashiwagi, R Kikkawa |
Kidney International | 2001 |
|
Risk predictors in patients with diabetic nephropathy
P Fioretto, ML Caramori, M Vestra, M Mauer |
Current Diabetes Reports | 2001 |
|
Association of angiotensinogen m235t and a(-6)g gene polymorphisms with coronary heart disease with independence of essential hypertension: the procagene study
JC Rodrı́guez-Pérez, F Rodrı́guez-Esparragón, O Hernández-Perera, A Anabitarte, A Losada, A Medina, E Hernández, D Fiuza, O Avalos, C Yunis, CM Ferrario |
Journal of the American College of Cardiology | 2001 |
|
Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease
E Lovati, A Richard, BM Frey, FJ Frey, P Ferrari |
Kidney International | 2001 |
|
Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study
LP Svetkey, TJ Moore, DG Simons-Morton, LJ Appel, GA Bray, FM Sacks, JD Ard, RM Mortensen, SR Mitchell, PR Conlin, M Kesari |
Journal of Hypertension | 2001 |
|
Diabetic nephropathy: Prevention and treatment
HH Parving |
Kidney International | 2001 |
|
Angiotensin-converting enzyme gene polymorphism and microvascular complications in Turkish type 2 diabetic patients
M Araz, N Yilmaz, K Güngör, V Okan, Y Kepekci, AS Aynacioglu |
Diabetes Research and Clinical Practice | 2001 |
|
Contribution of gene polymorphisms in the renin-angiotensin system to macroangiopathy in patients with diabetic nephropathy
TY Wong, CC Szeto, KM Chow, JC Chan, PK Li |
American Journal of Kidney Diseases | 2001 |
|
Insertion-deletion polymorphism in the gene for angiotensin-converting enzyme is associated with obstetric cholestasis but not with preeclampsia
JT Heiskanen, MM Pirskanen, MJ Hiltunen, AJ Mannermaa, KR Punnonen, ST Heinonen |
American Journal of Obstetrics and Gynecology | 2001 |
|
ACE Gene Polymorphism as a Prognostic Indicator in Patients With Type 2 Diabetes and Established Renal Disease
S Fava, J Azzopardi, S Ellard, AT Hattersley |
Diabetes care | 2001 |
|
THE DD GENOTYPE OF THE ACE GENE POLYMORPHISM IS ASSOCIATED WITH DIABETIC NEPHROPATHY IN TYPE-1 DIABETICS
ST Azar, PA Zalloua, R Medlej, G Halabi |
Endocrine Research | 2001 |
|
Loss of renal function following bone marrow transplantation: an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors
MB Juckett, EP Cohen, CA Keever-Taylor, Y Zheng, CA Lawton, JE Moulder, J Klein |
Bone Marrow Transplantation | 2001 |
|
Role of ACE Inhibitors in Patients with Diabetes Mellitus:
DJ Cordonnier, P Zaoui, S Halimi |
Drugs | 2001 |
|
Characterization of a Putative Insulin-Responsive Element and Its Binding Protein(s) in Rat Angiotensinogen Gene Promoter: Regulation by Glucose and Insulin*
X Chen, SL Zhang, L Pang, JG Filep, SS Tang, JR Ingelfinger, JS Chan |
Endocrinology | 2001 |
|
Klinische Diabetologie
BO Böhm, KD Palitzsch, C Rosak, GA Spinas |
2001 | |
|
Prognostic Value of Angiotensin-I Converting Enzyme I/D Polymorphism for Nephropathy in Type 1 Diabetes Mellitus: A Prospective Study
S Hadjadj, R Belloum, B Bouhanick, Y Gallois, G Guilloteau, G Chatellier, F Alhenc-Gelas, M Marre |
Journal of the American Society of Nephrology : JASN | 2001 |
|
Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients
M Araz, S Aynacioglu, S Aktaran, B Alasehirli, V Okan |
Acta Medica (Hradec Kralove, Czech Republic) | 2001 |
|
Risk predictors in patients with diabetic nephropathy
P Fioretto, ML Caramori, MD Vestra, M Mauer |
Current Diabetes Reports | 2001 |
|
Multi-hit nature of chronic renal disease
VD Nenov, MW Taal, OV Sakharova, BM Brenner |
Current Opinion in Nephrology and Hypertension | 2000 |
|
Mögliche genetische Ursachen für Spätkomplikationen des Diabetes mellitus
T Klemm, R Paschke |
Medizinische Klinik | 2000 |
|
Nihon Shoni Jinzobyo Gakkai Zasshi
A Matsunaga, K Hayasaka |
Nihon Shoni Jinzobyo Gakkai Zasshi | 2000 |
|
Genetic polymorphism of the renin-angiotensin system and organ damage in essential hypertension
R Pontremoli, M Ravera, F Viazzi, C Nicolella, V Berruti, G Leoncini, F Giacopelli, GP Bezante, G Sacchi, R Ravazzolo, G Deferrari |
Kidney International | 2000 |
|
Comprehensive analysis of the renin–angiotensin gene polymorphisms with relation to hypertension in the Japanese
N Kato, T Sugiyama, H Morita, H Kurihara, T Furukawa, T Isshiki, T Sato, Y Yamori, Y Yazaki |
Journal of Hypertension | 2000 |
|
Angiotensin-converting enzyme gene insertion/deletion polymorphism and renal damage in childhood uropathies
A Al-Eisa, MZ Haider, BS Srivastva |
Pediatrics International | 2000 |
|
Genes and diabetic nephropathy: what have we learnt so far?
G Dogra, GF Watts |
Practical Diabetes International | 2000 |
|
Angiotensin-converting enzyme gene polymorphisms in renal disease: clinically relevant?
MW Taal |
Current Opinion in Nephrology and Hypertension | 2000 |
|
Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study
CE Mogensen, S Neldam, I Tikkanen, S Oren, R Viskoper, RW Watts, ME Cooper |
BMJ (Clinical research ed.) | 2000 |
|
Association between high von Willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes
C Lacquemant, C Gaucher, C Delorme, G Chatellier, Y Gallois, M Rodier, P Passa, B Balkau, C Mazurier, M Marre, P Froguel |
Kidney International | 2000 |
|
Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein , lipoprotein lipase and cholesteryl ester transfer protein
S Hadjadj, Y Gallois, G Simard, B Bouhanick, P Passa, A Grimaldi, P Drouin, J Tichet, M Marre |
Nephrology Dialysis Transplantation | 2000 |
|
Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus
FJ van Ittersum, AM de Man, S Thijssen, P Knijff, E Slagboom, Y Smulders, L Tarnow, AJ Donker, HJ Bilo, CD Stehouwer |
Nephrology Dialysis Transplantation | 2000 |
|
Is it possible to predict diabetic kidney disease?
SM Thomas, GC Viberti |
Journal of Endocrinological Investigation | 2000 |
|
High Levels of Glucose Stimulate Angiotensinogen Gene Expression Via the P38 Mitogen-Activated Protein Kinase Pathway in Rat Kidney Proximal Tubular Cells 1
SL Zhang, SS Tang, X Chen, JG Filep, JR Ingelfinger, JS Chan |
Endocrinology | 2000 |
|
The Kidney and Hypertension in Diabetes Mellitus
CE Mogensen |
2000 | |
|
ACE Gene Polymorphism and Diabetic Complications: Is There a Connection?
B Kennon, JM Connell |
BioDrugs | 2000 |
|
THE MOLECULAR BASIS OF HYPERTENSION
DL Garbers, SK Dubois |
Annual Review of Biochemistry | 1999 |
|
Salt sensitivity and cardiovascular risk
A Bataineh, L Raij |
Current Opinion in Nephrology and Hypertension | 1999 |
|
Renal response to captopril reflects state of local renin system in healthy humans
ND Fisher, DA Price, WR Litchfield, GH Williams, NK Hollenberg |
Kidney International | 1999 |
|
Angiotensin I to angiotensin II conversion in the human forearm and leg. Effect of the angiotensin converting enzyme gene insertion/deletion polymorphism
AH Danser, J Deinum, AP Osterop, PJ Admiraal, MA Schalekamp |
Journal of Hypertension | 1999 |
|
Angiotensin-converting enzyme gene and diabetes mellitus
B Kennon, JR Petrie, M Small, JM Connell |
Diabetic Medicine | 1999 |
|
ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with Type 1 diabetes
SD Cosmo, M Margaglione, V Tassi, M Garrubba, S Thomas, C Olivetti, GP Piras, R Trevisan, M Vedovato, PC Perin, S Bacci, D Colaizzo, C Cisternino, L Zucaro, GD Minno, V Trischitta, GC Viberti |
Diabetes/Metabolism Research and Reviews | 1999 |
|
Effect of ACE gene on diabetic nephropathy in NIDDM patients with insulin resistance
N Kuramoto, T Iizuka, H Ito, K Yagui, M Omura, O Nozaki, T Nishikawa, H Tsuchida, H Makino, Y Saito, A Kanatsuka |
American Journal of Kidney Diseases | 1999 |
|
M235T angiotensinogen gene polymorphism and cardiovascular renal risk
JA Staessen, T Kuznetsova, JG Wang, D Emelianov, R Vlietinck, R Fagard |
Journal of Hypertension | 1999 |
|
Genetic susceptibility to end-stage renal disease
JR Schelling, L Zarif, A Sehgal, S Iyengar, JR Sedor |
Current Opinion in Nephrology and Hypertension | 1999 |
|
Genetic polymorphism of renin-angiotensin system is not associated with diabetic vascular complications in Japanese subjects with long-term insulin dependent diabetes mellitus
J Miura, Y Uchigata, H Yokoyama, Y Omori, Y Iwamoto |
Diabetes Research and Clinical Practice | 1999 |
|
Detection of point mutations on a DNA microchip
TG Hammond, A Hu, JM Hammond, MV Relling, JL Underwood |
Clinical Immunology Newsletter | 1999 |
|
Angiotensin-1 Converting Enzyme Polymorphisms in Chronic Beryllium Disease
LA Maier, MV Raynolds, DA Young, EA Barker, LS Newman |
American journal of respiratory and critical care medicine | 1999 |
|
Pronatriodilatin gene polymorphisms, microvascular permeability, and diabetic nephropathy in type 1 diabetes mellitus
M Nannipieri, G Penno, L Pucci, H Colhoun, C Motti, A Bertacca, L Rizzo, LD Giorgio, G Zerbini, R Mangili, R Navalesi |
Journal of the American Society of Nephrology : JASN | 1999 |
|
Lack of association of angiotensin-converting enzyme (Dd/II) and angiotensinogen M235T gene polymorphism with renal function among Chinese patients with type II diabetes
TY Wong, JC Chan, E Poon, PK Li |
American Journal of Kidney Diseases | 1999 |
|
Angiotensin-Converting Enzyme Gene Polymorphism: Is There a Link to Nephropathy in Patients with Type 1 Diabetes?
JK Martin, MS Hayney |
The Annals of pharmacotherapy | 1999 |
|
Renal Changes on Hyperglycemia and Angiotensin-Converting Enzyme in Type 1 Diabetes
M Marre, B Bouhanick, G Berrut, Y Gallois, JJ Jeune, G Chatellier, J Menard, F Alhenc-Gelas |
Hypertension | 1999 |
|
Hyperglycemia and Angiotensin-Mediated Control of the Renal Circulation in Healthy Humans
SY Osei, DA Price, ND Fisher, L Porter, LM Laffel, NK Hollenberg |
Hypertension | 1999 |
|
Plasma renin and prorenin and renin gene variation in patients with insulin-dependent diabetes mellitus and nephropathy
J Deinum, L Tarnow, JM van Gool, RA de Bruin, FH Derkx, MA Schalekamp, HH Parving |
Nephrology Dialysis Transplantation | 1999 |
|
Expansion of Cortical Interstitium Is Limited by Converting Enzyme Inhibition in Type 2 Diabetic Patients with Glomerulosclerosis
DJ Cordonnier, N Pinel, C Barro, C Maynard, P Zaoui, S Halimi, BH Ligny, Y Reznic, D Simon, RW Bilous |
Journal of the American Society of Nephrology : JASN | 1999 |
|
RENAL ANGIOTENSIN CONVERTING ENZYME PROMOTES RENAL DAMAGE DURING URETERAL OBSTRUCTION
BJ Stoneking, TE Hunley, H Nishimura, J Ma, A Fogo, T Inagami, M Tamura, MC Adams, JW Brock, V Kon |
The Journal of Urology | 1998 |
|
Angiotensin II, nitric oxide, and end-organ damage in hypertension
A Bataineh, L Raij |
Kidney International | 1998 |
|
Angiotensinogen (M235T) and angiotensin-converting enzyme (I/D) polymorphisms in association with plasma renin and prorenin levels
AH Danser, FH Derkx, HW Hense, X Jeunemaître, GA Riegger, H Schunkert |
Journal of Hypertension | 1998 |
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Hypertension
P Hamet, Z Pausova, V Adarichev, K Adaricheva, J Tremblay |
Journal of Hypertension | 1998 |
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Gene polymorphism and chronic renal diseases
H Yoshida |
Clinical and Experimental Nephrology | 1998 |
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Polymorphisms of angiotensin converting enzyme and plasminogen activator inhibitor-1 genes in diabetes and macroangiopathy1
H Kimura, F Gejyo, Y Suzuki, S Suzuki, R Miyazaki, M Arakawa |
Kidney International | 1998 |
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ROLE OF THE RENIN-ANGIOTENSIN SYSTEM IN DISORDERS OF THE URINARY TRACT
JW Brock, TE Hunley, MC Adams, V Kon |
The Journal of Urology | 1998 |
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Angiotensin converting enzyme gene polymorphisms and renal disease
AG Jardine, N Padmanabhan, JM Connell |
Current Opinion in Nephrology and Hypertension | 1998 |
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Genetic polymorphisms of the renin-angiotensin system and the outcome of focal segmental glomerulosclerosis in children
Y Frishberg, R Becker-Cohen, D Halle, E Feigin, B Eisenstein, R Halevy, D Lotan, I Juabeh, N Ish-Shalom, D Magen, Y Shvil, L Sinai-Treiman, A Drukker |
Kidney International | 1998 |
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Deletion polymorphism of the angiotensin converting enzyme gene predicts persistent proteinuria in Henoch-Schönlein purpura nephritis
T Yoshioka, YX Xu, H Yoshida, H Shiraga, T Muraki, K Ito |
Archives of disease in childhood | 1998 |
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Pathogenesis, prevention, and treatment of diabetic nephropathy
ME Cooper |
The Lancet | 1998 |
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Advances in Protein Chemistry
CM Silva, J Isgaard, MO Thorner |
Advances in Protein Chemistry | 1998 |
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Diabetic Nephropathy Is Associated With AGT Polymorphism T235: Results of a Family-Based Study
JJ Rogus, D Moczulski, MB Freire, Y Yang, JH Warram, AS Krolewski |
Hypertension | 1998 |
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Nitric Oxide in Hypertension: Relationship With Renal Injury and Left Ventricular Hypertrophy
L Raij |
Hypertension | 1998 |
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The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk
JA Staessen, JG Wang, G Ginocchio, V Petrov, AP Saavedra, F Soubrier, R Vlietinck, R Fagard |
Journal of Hypertension | 1997 |
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Cardiovascular complications of diabetes
S Caprio, S Wong, KG Alberti, G King |
Diabetologia | 1997 |
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Molecular Genetics of Human Hypertension: Role of Angiotensinogen*
P Corvol, X Jeunemaitre |
Endocrine reviews | 1997 |
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The renin-angiotensin system in streptozotocin-induced diabetes mellitus in the rat
DJ Campbell, DJ Kelly, JL Wilkinson-Berka, ME Cooper, SL Skinner |
Journal of the American Society of Nephrology : JASN | 1993 |
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The renin-angiotensin system in streptozotocin-induced diabetes mellitus in the rat
DJ Campbell, DJ Kelly, JL Wilkinson-Berka, ME Cooper, SL Skinner |
Journal of the American Society of Nephrology : JASN | 1993 |
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