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Citations to this article

Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.
S M Cohn, … , K Seibert, W F Stenson
S M Cohn, … , K Seibert, W F Stenson
Published March 15, 1997
Citation Information: J Clin Invest. 1997;99(6):1367-1379. https://doi.org/10.1172/JCI119296.
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Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.

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Abstract

Prostaglandins (PGs) are important mediators of epithelial integrity and function in the gastrointestinal tract. Relatively little is known, however, about the mechanism by which PGs affect stem cells in the intestine during normal epithelial turnover, or during wound repair. PGs are synthesized from arachidonate by either of two cyclooxygenases, cyclooxygenase-1 (Cox-1) or cyclooxygenase-2 (Cox-2), which are present in a wide variety of mamalian cells. Cox-1 is thought to be a constitutively expressed enzyme, and the expression of Cox-2 is inducible by cytokines or other stimuli in a variety of cell types. We investigated the role of PGs in mouse intestinal stem cell survival and proliferation following radiation injury. The number of surviving crypt stem cells was determined 3.5 d after irradiation by the microcolony assay. Radiation injury induced a dose-dependent decrease in the number of surviving crypts. Indomethacin, an inhibitor of Cox-1 and Cox-2, further reduced the number of surviving crypts in irradiated mice. The indomethacin dose response for inhibition of PGE2 production and reduction of crypt survival were similar. DimethylPGE2 reversed the indomethacin-induced decrease in crypt survival. Selective Cox-2 inhibitors had no effect on crypt survival. PGE2, Cox-1 mRNA, and Cox-1 protein levels all increase in the 3 d after irradiation. Immunohistochemistry for Cox-1 demonstrated localization in epithelial cells of the crypt in the unirradiated mouse, and in the regenerating crypt epithelium in the irradiated mouse. We conclude that radiation injury results in increased Cox-1 levels in crypt stem cells and their progeny, and that PGE2 produced through Cox-1 promotes crypt stem cell survival and proliferation.

Authors

S M Cohn, S Schloemann, T Tessner, K Seibert, W F Stenson

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CW Houchen, MA Sturmoski, S Anant, RM Breyer, WF Stenson
AJP Gastrointestinal and Liver Physiology 2003
Ventromedial hypothalamus lesions induce jejunal epithelial cell hyperplasia through an increase in gene expression of cyclooxygenase
H Kageyama, A Kageyama, Y Endo, T Osaka, K Nemoto, T Hirano, Y Namba, S Shioda, S Inoue
International Journal of Obesity 2003
Basic fibroblast growth factor upregulates cyclooxygenase-2 in I407 cells through p38 MAP kinase
TG Tessner, F Muhale, S Schloemann, SM Cohn, A Morrison, WF Stenson
AJP Gastrointestinal and Liver Physiology 2003
Microbial Pathogenesis and the Intestinal Epithelial Cell
GA Hecht
2003
COX-1, COX-2 and the topical effect in NSAID-induced enteropathy
CM Hotz-Behofsits, MJ Walley, R Simpson, IT Bjarnason
Inflammopharmacology 2003
Impaired mucosal integrity and enhanced immune response in colitis in mice lacking prostaglandin E receptor EP4
Kenji Kabashima, Tomomi Saji, Takahiko Murata, Miyako Nagamachi, Toshiyuki Matsuoka, Eri Segi, Kazuhito Tsuboi, Yukihiko Sugimoto, Takuya Kobayashi, Yoshiki Miyachi, Atsushi Ichikawa, Shuh Narumiya
Journal of Clinical Investigation 2002
CYCLOOXYGENASE-2: A Therapeutic Target
ME Turini, RN DuBois
Annual Review of Medicine 2002
Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis
D Washo-Stultz, CL Crowley-Weber, K Dvorakova, C Bernstein, H Bernstein, K Kunke, CN Waltmire, H Garewal, CM Payne
Cancer Letters 2002
Regulation of progesterone and prostaglandin F2α production in the CL
FJ Diaz, LE Anderson, YL Wu, A Rabot, SJ Tsai, MC Wiltbank
Molecular and Cellular Endocrinology 2002
Potential role of the membrane in the development of intestinal cellular damage after whole-body gamma irradiation of the rat
F Lebrun, M Benderitter, A Berroud, P Voisin, NM Griffiths
Canadian Journal of Physiology and Pharmacology 2002
Impact of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on gastric ulcerogenesis in experimental animals and in humans
T Pawlik, PC Konturek, JW Konturek, SJ Konturek, T Brzozowski, M Cześnikiewicz, M Plonka, W Bielanski, H Areny
European Journal of Pharmacology 2002
A novel human fibroblast growth factor treats experimental intestinal inflammation
M Jeffers, WF McDonald, RA Chillakuru, M Yang, H Nakase, LL Deegler, ED Sylander, B Rittman, A Bendele, RB Sartor, HS Lichenstein
Gastroenterology 2002
Rapid development of colitis in NSAID-treated IL-10–deficient mice
DJ Berg, J Zhang, JV Weinstock, HF Ismail, KA Earle, H Alila, R Pamukcu, S Moore, RG Lynch
Gastroenterology 2002
Role of human heme oxygenase-1 in attenuating TNF-?-mediated inflammation injury in endothelial cells
T Kushida, GL Volti, S Quan, A Goodman, NG Abraham
Journal of Cellular Biochemistry 2002
Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration
DA Rudnick, DH Perlmutter, LJ Muglia
Proceedings of the National Academy of Sciences 2001
Molecular mechanisms contributing to necrotizing enterocolitis
DH Chung, RT Ethridge, S Kim, S Owens-Stovall, A Hernandez, DR Kelly, BM Evers
Annals of Surgery 2001
Regulation of cyclo-oxygenase-2
E Stack, RN DuBois
Best Practice & Research Clinical Gastroenterology 2001
Celecoxib, a selective cyclo-oxygenase-2 inhibitor reduces the severity of experimental colitis induced by dinitrobenzene sulfonic acid in rats
S Cuzzocrea, E Mazzon, I Serraino, L Dugo, T Centorrino, A Ciccolo, L Sautebin, AP Caputi
European Journal of Pharmacology 2001
Expression of cyclooxygenase-2 protein in colon disease
H Lu, Z Ge, W Liu, X Chen, Y Peng, S Xiao
Chinese Journal of Digestive Diseases 2001
Molecular Mechanisms Contributing to Necrotizing Enterocolitis
DH Chung, RT Ethridge, S Kim, S Owens-Stovall, A Hernandez, DR Kelly, BM Evers
Annals of Surgery 2001
CLINICAL IMPLICATIONS OF PROSTAGLANDIN INHIBITION IN THE SMALL BOWEL
CW Houchen
Gastroenterology Clinics of North America 2001
Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E2 production and neurodegeneration in cortical and hippocampal cell cultures
EJ Kim, JE Lee, KJ Kwon, SH Lee, CH Moon, EJ Baik
Brain Research 2001
Inflammation
JA Hunt
Encyclopedia of Materials Science and Technology 2001
Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus
NT Schwarz, JC Kalff, A Türler, BM Engel, SC Watkins, TR Billiar, AJ Bauer
Gastroenterology 2001
Effects of Nonsteroidal Anti-Inflammatory Drugs on Helicobacter pylori -Infected Gastric Mucosae of Mice: Apoptosis, Cell Proliferation, and Inflammatory Activity
JD Clements, TI Kim, YC Lee, KH Lee, JH Han, CY Chon, YM Moon, JK Kang, IS Park
Infection and immunity 2001
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
O Morteau, SG Morham, R Sellon, LA Dieleman, R Langenbach, O Smithies, RB Sartor
Journal of Clinical Investigation 2000
Review article: new insights into the pathogenesis of radiation-induced intestinal dysfunction
Macnaughton
Alimentary Pharmacology & Therapeutics 2000
Cyclooxygenase-2 and carcinogenesis
SM Prescott, FA Fitzpatrick
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2000
Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism
T Riehl, S Cohn, T Tessner, S Schloemann, WF Stenson
Gastroenterology 2000
Myofibroblasts: paracrine cells important in health and disease
DW Powell
Transactions of the American Clinical and Climatological Association 2000
Eicosanoids and the small intestine
B Mohajer, TY Ma
Prostaglandins & Other Lipid Mediators 2000
Aspirine, douleurs et inflammation
P Vergne, P Bertin, R Trèves
La Revue de Médecine Interne 2000
Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury
CW Houchen, WF Stenson, SM Cohn
AJP Gastrointestinal and Liver Physiology 2000
Keratinocyte growth factor-2 (FGF-10) promotes healing of experimental small intestinal ulceration in rats
DS Han, F Li, L Holt, K Connolly, M Hubert, R Miceli, Z Okoye, G Santiago, K Windle, E Wong, RB Sartor
AJP Gastrointestinal and Liver Physiology 2000
The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64
RT Cormier, A Bilger, AJ Lillich, RB Halberg, KH Hong, KA Gould, N Borenstein, ES Lander, WF Dove
Oncogene 2000
Mode of action of ANG II on ion transport in guinea pig distal colon
Y Hosoda, A Winarto, T Iwanaga, A Kuwahara
AJP Gastrointestinal and Liver Physiology 2000
Effect of Intrarectal Prostaglandin E 2 Analogue (Enprostil) on Trinitrobenzenesulphonic Acid-Induced Colitis in Rats
Y Onizuka, K Murase, H Furusu, H Isomoto, Y Mizuta, F Takeshima, K Makiyama, S Kohno
J INT MED RES 2000
Cyclooxygenase-1 and an alternatively spliced mRNA in the rat stomach: effects of aging and ulcers
D Vogiagis, EM Glare, A Misajon, W Brown, PE O'Brien
AJP Gastrointestinal and Liver Physiology 2000
Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from γ-irradiation damage
RS Esworthy, JR Mann, M Sam, FF Chu
AJP Gastrointestinal and Liver Physiology 2000
Low endogenous prostaglandin E2 predisposes to relapsing inflammation in experimental rat enterocolitis
H M Kandil, R A Argenzio, R B Sartor
Digestive Diseases and Sciences 2000
Cyclooxygenase expression in intestinal epithelial cells
CW Houchen, WF Stenson
Current Opinion in Gastroenterology 1999
Cyclooxygenase 2 selective inhibitors: Panacea or flash in the pan?
U Beejay, MM Wolfe
Gastroenterology 1999
Selective cyclooxygenase-2 inhibitors as non-ulcerogenic anti-inflammatory agents
AS Kalgutkar
Expert Opinion on Therapeutic Patents 1999
Myofibroblasts. I. Paracrine cells important in health and disease
D Li, SL Friedman
The American journal of physiology 1999
Myofibroblasts. II. Intestinal subepithelial myofibroblasts
DW Powell, RC Mifflin, JD Valentich, SE Crowe, JI Saada, AB West
American journal of physiology. Cell physiology 1999
Prostaglandin-induced recovery of barrier function in porcine ileum is triggered by chloride secretion
AT Blikslager, MC Roberts, RA Argenzio
AJP Gastrointestinal and Liver Physiology 1999
Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival
CM Hao, M Kömhoff, Y Guan, R Redha, MD Breyer
American journal of physiology. Renal physiology 1999
Gastrointestinal Pharmacology
DE Freeman
The Veterinary clinics of North America. Equine practice 1999
Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen
RD Newberry, WF Stenson, RG Lorenz
Nature Medicine 1999
FGF-2 enhances intestinal stem cell survival and its expression is induced after radiation injury
CW Houchen, RJ George, MA Sturmoski, SM Cohn
AJP Gastrointestinal and Liver Physiology 1999
Differential expression of interleukin 1 receptor antagonist isoforms in human intestinal epithelial cells
U Böcker, A Damião, L Holt, DS Han, C Jobin, A Panja, L Mayer, RB Sartor
Gastroenterology 1998
Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease
II Singer, DW Kawka, S Schloemann, T Tessner, T Riehl, WF Stenson
Gastroenterology 1998
CYCLOOXYGENASES 1 AND 2
JR Vane, YS Bakhle, RM Botting
Annual Review of Pharmacology and Toxicology 1998
Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells
JOBIN, MORTEAU, HAN, BALFOUR SARTOR
Immunology 1998
Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice
TG Tessner, SM Cohn, S Schloemann, WF Stenson
Gastroenterology 1998
Cyclooxygenase in biology and disease
RN Dubois, SB Abramson, L Crofford, RA Gupta, LS Simon, LB Putte, PE Lipsky
The FASEB Journal 1998
Selective COX-2 Inhibitors
J Vane, J Botting
1998
Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells.
Jobin C, Morteau O, Han DS, Balfour Sartor R
Immunology 1998
Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production
L Eckmann, WF Stenson, TC Savidge, DC Lowe, KE Barrett, J Fierer, JR Smith, MF Kagnoff
Journal of Clinical Investigation 1997

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