It is well documented that the activity of Na+,K+-ATPase can be inhibited by the arachidonic acid metabolite, 20-hydroxyeicosa-tetraenoic acid (20 HETE). Evidence is presented here that this effect is mediated by protein kinase C (PKC). PKC inhibitors abolished 20 HETE inhibition of rat Na+,K+-ATPase in renal tubular cells. 20 HETE caused translocation of PKC alpha from cytoplasm to membrane in COS cells. It also inhibited Na+,K+-ATPase activity in COS cells transfected with rat wild-type renal Na+,K+-ATPase alpha1 subunit, but not in cells transfected with Na+,K+-ATPase alpha1, where the PKC phosphorylation site, serine 23, had been mutated to alanine. PKC-induced phosphorylation of rat renal Na+,K+-ATPase, as well as of histone was strongly enhanced by 20 HETE at the physiologic calcium concentration of 1.3 microM, but not at the calcium concentration of 200 microM. The results indicate that phospholipase A2-arachidonic acid-20 HETE pathway can exert important biological effects via activation of PKC and that this effect may occur in the absence of a rise in intracellular calcium.
S Nowicki, S L Chen, O Aizman, X J Cheng, D Li, C Nowicki, A Nairn, P Greengard, A Aperia
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Physiological Reports | 2014 |
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PloS one | 2013 |
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Prostaglandins & Other Lipid Mediators | 2012 |
Renal Medullary Circulation
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Comprehensive Physiology | 2012 |
Brenner and Rector's The Kidney
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Brenner and Rector's The Kidney | 2012 |
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Journal of Neurochemistry | 2012 |
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Comprehensive Hypertension
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Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier
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American journal of physiology. Renal physiology | 2007 |
Hypertension and Hormone Mechanisms
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2007 | |
Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species
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American journal of respiratory cell and molecular biology | 2006 |
Kidney Dysfunction and Hypertension: Role for Cadmium, P450 and Heme Oxygenases?
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The Tohoku Journal of Experimental Medicine | 2006 |
Molecular Mechanisms in Hypertension: paracrine regulator of salt sensitivity and blood pressure
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Molecular Mechanisms in Hypertension: paracrine regulator of salt sensitivity and blood pressure | 2006 |
The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks
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American journal of respiratory cell and molecular biology | 2005 |
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The American Journal of Pathology | 2005 |
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American journal of physiology. Renal physiology | 2005 |
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American journal of physiology. Renal physiology | 2005 |
Cytochrome P450
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Cytochrome P450 | 2005 |
Activation of Na+-Independent Mg2+ Efflux by 20-Hydroxyeicosatetraenoic Acid in Rat Renal Epithelial Cells
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The Japanese Journal of Physiology | 2004 |
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Critical Care Medicine | 2004 |
Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis
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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
Functional genomics of the dopaminergic system in hypertension
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Physiological genomics | 2004 |
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American journal of physiology. Renal physiology | 2004 |
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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
Transfection and Functional Expression of CYP4A1 and CYP4A2 Using Bicistronic Vectors in Vascular Cells and Tissues
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The Journal of pharmacology and experimental therapeutics | 2004 |
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Steroids | 2003 |
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European Journal of Pharmacology | 2003 |
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Prostaglandins & Other Lipid Mediators | 2003 |
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Experimental biology and medicine (Maywood, N.J.) | 2003 |
Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries
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American journal of physiology. Renal physiology | 2003 |
Renal Function in a Rat Model of Analgesic Nephropathy: Effect of Chloroquine
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The Journal of pharmacology and experimental therapeutics | 2003 |
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P -450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function
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Physiological reviews | 2002 |
Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na + -K + -ATPase activity
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American journal of physiology. Renal physiology | 2002 |
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American journal of physiology. Renal physiology | 2002 |
Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule
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American journal of physiology. Renal physiology | 2001 |
Cytochrome P450 metabolites of arachidonic acid in the control of renal function
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Current Opinion in Nephrology and Hypertension | 2001 |
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European Journal of Biochemistry | 2001 |
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The Journal of Nutritional Biochemistry | 2001 |
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Cytochrome P450 metabolites of arachidonic acid: novel regulators of renal function
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Downstream Shift in Sodium Pump Activity along the Nephron during Acute Hypertension
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The Journal of biological chemistry | 2001 |
Renal And Cardiovascular Actions Of 20-Hydroxyeicosatetraenoic Acid And Epoxyeicosatrienoic Acids
RJ Roman, KG Maier, CW Sun, DR Harder, M Alonso-Galicia |
Clinical and Experimental Pharmacology and Physiology | 2000 |
Intrarenal Dopamine: A Key Signal in the Interactive Regulation of Sodium Metabolism
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Annual Review of Physiology | 2000 |
Mechanisms of sodium pump regulation
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American journal of physiology. Cell physiology | 2000 |
Interaction of Protein Kinase C and cAMP-dependent Pathways in the Phosphorylation of the Na,K-ATPase
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The Journal of biological chemistry | 2000 |
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American journal of physiology. Renal physiology | 2000 |
Formation of 20-Hydroxyeicosatetraenoic Acid, a Vasoactive and Natriuretic Eicosanoid, in Human Kidney: ROLE OF CYP4F2 AND CYP4A11
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The Journal of biological chemistry | 2000 |
Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow
D Gebremedhin, AR Lange, TF Lowry, MR Taheri, EK Birks, AG Hudetz, J Narayanan, JR Falck, H Okamoto, RJ Roman, K Nithipatikom, WB Campbell, DR Harder |
Circulation research | 2000 |
Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase
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Journal of lipid research | 2000 |
Regulation of Na/K-ATPase beta1-subunit gene expression by ouabain and other hypertrophic stimuli in neonatal rat cardiac myocytes
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Molecular and Cellular Biochemistry | 2000 |
20-Hydroxyeicosatetraenoic acid and renal function in Lyon hypertensive rats
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European Journal of Pharmacology | 1999 |
Glucose Decreases Na + ,K + -ATPase Activity in Pancreatic β-Cells: AN EFFECT MEDIATED VIA Ca 2+ -INDEPENDENT PHOSPHOLIPASE A 2 AND PROTEIN KINASE CDEPENDENT PHOSPHORYLATION OF THE α-SUBUNIT
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The Journal of biological chemistry | 1999 |
20-HETE and the kidney: resolution of old problems and new beginnings
JC McGiff, J Quilley |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 1999 |
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American journal of physiology. Renal physiology | 1999 |
In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition
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American journal of physiology. Renal physiology | 1999 |
Role of Tyrosine Kinase and PKC in the Vasoconstrictor Response to 20-HETE in Renal Arterioles
CW Sun, JR Falck, DR Harder, RJ Roman |
Hypertension | 1999 |
Potential Role of Glycerol Leading to Rat Fructose Hypertension
PF Damiano, MI Rosón, I Armando, S Nowicki, E Dascal, L Cuniberti, LE Albornoz, IJ de la Riva |
Hypertension | 1999 |
Renal Dopamine Receptors in Health and Hypertension
PA Jose, GM Eisner, RA Felder |
Pharmacology & Therapeutics | 1998 |
Phosphatidylinositol 3-kinase-mediated endocytosis of renal Na+, K+-ATPase alpha subunit in response to dopamine
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Molecular biology of the cell | 1998 |
Phosphorylation of the Catalyic α-Subunit Constitutes a Triggering Signal for Na + ,K + -ATPase Endocytosis
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The Journal of biological chemistry | 1998 |
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American journal of physiology. Cell physiology | 1998 |
Cytochrome P450 products and renal function in cirrhosis: The hete is on
K Moore |
Hepatology | 1998 |
Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries
M Alonso-Galicia, CW Sun, JR Falck, DR Harder, RJ Roman |
American journal of physiology. Renal physiology | 1998 |
Effects of Lipid-Lowering Agents in the Dahl Salt-Sensitive Rat
TW Wilson, M Alonso-Galicia, RJ Roman |
Hypertension | 1998 |
20-Hydroxyeicosatetraenoic Acid-induced Vasoconstriction and Inhibition of Potassium Current in Cerebral Vascular Smooth Muscle Is Dependent on Activation of Protein Kinase C
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