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Citations to this article

20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase.
S Nowicki, … , P Greengard, A Aperia
S Nowicki, … , P Greengard, A Aperia
Published March 15, 1997
Citation Information: J Clin Invest. 1997;99(6):1224-1230. https://doi.org/10.1172/JCI119279.
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Research Article

20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase.

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Abstract

It is well documented that the activity of Na+,K+-ATPase can be inhibited by the arachidonic acid metabolite, 20-hydroxyeicosa-tetraenoic acid (20 HETE). Evidence is presented here that this effect is mediated by protein kinase C (PKC). PKC inhibitors abolished 20 HETE inhibition of rat Na+,K+-ATPase in renal tubular cells. 20 HETE caused translocation of PKC alpha from cytoplasm to membrane in COS cells. It also inhibited Na+,K+-ATPase activity in COS cells transfected with rat wild-type renal Na+,K+-ATPase alpha1 subunit, but not in cells transfected with Na+,K+-ATPase alpha1, where the PKC phosphorylation site, serine 23, had been mutated to alanine. PKC-induced phosphorylation of rat renal Na+,K+-ATPase, as well as of histone was strongly enhanced by 20 HETE at the physiologic calcium concentration of 1.3 microM, but not at the calcium concentration of 200 microM. The results indicate that phospholipase A2-arachidonic acid-20 HETE pathway can exert important biological effects via activation of PKC and that this effect may occur in the absence of a rise in intracellular calcium.

Authors

S Nowicki, S L Chen, O Aizman, X J Cheng, D Li, C Nowicki, A Nairn, P Greengard, A Aperia

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M Alonso-Galicia, CW Sun, JR Falck, DR Harder, RJ Roman
American journal of physiology. Renal physiology 1998
Effects of Lipid-Lowering Agents in the Dahl Salt-Sensitive Rat
TW Wilson, M Alonso-Galicia, RJ Roman
Hypertension 1998
20-Hydroxyeicosatetraenoic Acid-induced Vasoconstriction and Inhibition of Potassium Current in Cerebral Vascular Smooth Muscle Is Dependent on Activation of Protein Kinase C
A Lange, D Gebremedhin, J Narayanan, D Harder
The Journal of biological chemistry 1997
Nitric Oxide
RA Schroeder, PC Kuo
Anesthesia & Analgesia 1995

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