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Citations to this article

Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment.
A Wald, … , G Davis, J Zeh
A Wald, … , G Davis, J Zeh
Published March 1, 1997
Citation Information: J Clin Invest. 1997;99(5):1092-1097. https://doi.org/10.1172/JCI119237.
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Research Article Article has an altmetric score of 12

Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment.

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Abstract

Reactivation of herpes simplex virus type 2 (HSV-2) occurs intermittently as perceived clinically and by viral culture. We performed a series of studies to evaluate the frequency and pattern of HSV-2 reactivation using both viral isolation and HSV PCR assay. Daily samples of genital secretions were obtained from 27 HSV-2 seropositive women; a subset of subjects obtained samples while receiving oral acyclovir 400 mg PO twice a day. HSV DNA was detected in genital swab specimens on 28% of 1,410 d compared with 8.1% of days by viral isolation. 11 of 20 women had HSV DNA detected on > 20% of days, 4 on > 50%, and 2 on > 75% of days; in contrast, none of the women shed on > 21% of days by viral isolation. The daily administration of oral acyclovir promptly reduced the frequency of HSV DNA detection by a median of 80%. Within 3-4 d of discontinuing daily acyclovir, HSV DNA again appeared in the genital area. HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide.

Authors

A Wald, L Corey, R Cone, A Hobson, G Davis, J Zeh

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Total citations by year

Year: 2025 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1988 Total
Citations: 1 2 2 6 5 1 8 7 3 10 11 8 17 14 17 12 13 11 14 15 17 15 16 8 22 18 12 1 1 287
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Citations to this article in year 2012 (17)

Title and authors Publication Year
An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection
T Peng, J Zhu, K Phasouk, DM Koelle, A Wald, L Corey
Journal of virology 2012
Future of an “Asymptomatic” T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine
X Dervillez, C Gottimukkala, KW Kabbara, C Nguyen, T Badakhshan, SM Kim, AB Nesburn, SL Wechsler, L Benmohamed
Future Virology 2012
Targeted DNA mutagenesis for the cure of chronic viral infections
JT Schiffer, M Aubert, ND Weber, E Mintzer, D Stone, KR Jerome
Journal of virology 2012
Immunodominant “Asymptomatic” Herpes Simplex Virus 1 and 2 Protein Antigens Identified by Probing Whole-ORFome Microarrays with Serum Antibodies from Seropositive Asymptomatic versus Symptomatic Individuals
G Dasgupta, AA Chentoufi, M Kalantari, P Falatoonzadeh, S Chun, CH Lim, PL Felgner, DH Davies, L BenMohamed
Journal of virology 2012
A miniaturized and integrated gel post platform for multiparameter PCR detection of herpes simplex viruses from raw genital swabs
DP Manage, J Lauzon, A Atrazhev, YC Morrissey, AL Edwards, AJ Stickel, HJ Crabtree, K Pabbaraju, G Zahariadis, SK Yanow, LM Pilarski
Lab on a Chip 2012
HSV-2 vaccine: Current state and insights into development of a vaccine that targets genital mucosal protection
K Roth, V Ferreira, C Kaushic
Microbial Pathogenesis 2012
Etiologic Pattern of Genital Ulcers in Lusaka, Zambia: Has Chancroid Been Eliminated?
M Makasa, A Buve, IF Sandøy
Sexually Transmitted Diseases 2012
Mucosal herpes immunity and immunopathology to ocular and genital herpes simplex virus infections
AA Chentoufi, L Benmohamed
Clinical & developmental immunology 2012
Neonatal herpes simplex virus infection
TL Cherpes, DB Matthews, SA Maryak
Clinical Obstetrics and Gynecology 2012
HSV-1 latent rabbits shed viral DNA into their saliva
JM Hill, NM Nolan, HE McFerrin, C Clement, TP Foster, WP Halford, KG Kousoulas, WJ Lukiw, HW Thompson, EM Stern, PS Bhattacharjee
Virology Journal 2012
Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profiling
M Kalantari-Dehaghi, S Chun, AA Chentoufi, J Pablo, L Liang, G Dasgupta, DM Molina, A Jasinskas, R Nakajima-Sasaki, J Felgner, G Hermanson, L BenMohamed, PL Felgner, DH Davies
Journal of virology 2012
Equal HIV-1 Decay Kinetics in HSV-2-Infected and -Uninfected Clinical Trial Participants Treated with Antiretroviral Therapy
JT Schouten, JT Schiffer
Journal of acquired immune deficiency syndromes (1999) 2012
?Herpes present? reported in a routine cervical cytology and how to deal with it
SJ Winceslaus, T Levine
Sexual Health 2012
Current trends in negative immuno-synergy between two sexually transmitted infectious viruses: HIV-1 and HSV-1/2
AA Chentoufi, X Dervillez, PA Rubbo, T Kuo, X Zhang, N Nagot, E Tuaillon, PV de Perre, AB Nesburn, L Benmohamed
Current trends in immunology 2012
Towards a Rational Design of an Asymptomatic Clinical Herpes Vaccine: The Old, the New, and the Unknown
AA Chentoufi, E Kritzer, DM Yu, AB Nesburn, L BenMohamed
Clinical and Developmental Immunology 2012
Herpes simplex virus and HIV: genital infection synergy and novel approaches to dual prevention
AR Thurman, GF Doncel
International Journal of STD & AIDS 2012
Maintenance of T Cell Function in the Face of Chronic Antigen Stimulation and Repeated Reactivation for a Latent Virus Infection
LK Mackay, L Wakim, CJ van Vliet, CM Jones, SN Mueller, O Bannard, DT Fearon, WR Heath, FR Carbone
Journal of immunology (Baltimore, Md. : 1950) 2012

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