Citations to this article

Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon.
H M Karpoff, … , H Federoff, Y Fong
H M Karpoff, … , H Federoff, Y Fong
Published February 15, 1997
Citation Information: J Clin Invest. 1997;99(4):799-804. https://doi.org/10.1172/JCI119226.
View: Text | PDF
Research Article Article has an altmetric score of 3

Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon.

Abstract

Previous studies showed that gammaIFN decreases metastatic hepatic tumor growth by stimulating Kupffer cells (KC). The present studies examine whether lymphocyte stimulation via cells engineered to secrete GM-CSF or IL-2 decreases hepatic tumor growth, and whether stimulation of both macrophages and lymphocytes is more effective than either individually. Rats were immunized with irradiated hepatoma cells transduced by herpes viral amplicon vectors containing the genes for GM-CSF, IL-2 or LacZ. On day 18, half of each group was treated with 5 x 10(4) U gammaIFN, or saline intraperitoneally for 3 d. On day 21, all rats received 5 x 10(5) hepatoma cells intrasplenically. On day 41, rats were killed and tumor nodules were counted. Separate rats underwent splenocyte and KC harvest for assessment of lymphocyte- and macrophage-mediated tumor cell kill in vitro. GM-CSF or IL-2 vaccines or gammaIFN decreased tumor nodules significantly (GM-CSF 13+/-4, IL-2 14+/-6 vs. control 75+/-24, P < 0.001). Combination therapy was more effective, and completely eliminated tumor in 4 of 12 IFN-GM-CSF and 8 of 11 IFN-IL-2 animals. Additional rats underwent partial hepatectomy, an immunosuppressive procedure known to accelerate the growth of hepatic tumor, following tumor challenge. Therapy was equally effective in this immunosuppressive setting. Vaccination is associated with enhancement of splenocyte-mediated tumoricidal activity, whereas the effect of gammaIFN is mediated by KC. GM-CSF and IL-2 vaccine therapy and pretreatment with gammaIFN represent effective strategies in reducing hepatic tumor. Combination therapy targets both lymphocytes and macrophages, and is more effective in reducing tumor than either therapy alone.

Authors

H M Karpoff, M D'Angelica, S Blair, M D Brownlee, H Federoff, Y Fong

×

Total citations by year

Year: 2013 2012 2011 2007 2004 2003 2002 2001 2000 1999 1998 Total
Citations: 2 1 1 1 2 2 3 9 6 5 3 35
Citation information

Citations to this article (35)

Title and authors Publication Year
Irreversible electroporation facilitates gene transfer of a GM-CSF plasmid with a local and systemic response
JT Au, A Mittra, TJ Song, M Cavnar, K Jun, J Carson, S Gholami, D Haddad, S Gaujoux, S Monette, P Ezell, J Wolchok, Y Fong 		Surgery 2013
Kupffer Cells Suppress Hepatocarcinogenesis and Metastasis in Tumor Orthotopic Implanted Kunming Mice
XY Li, MY Wang, JY Zhang, JZ Li, JP Gong, W Zhang 		Asian Pacific Journal of Cancer Prevention 2013
Role of Stem Cell Factor and Granulocyte-Colony Stimulating Factor in Remodeling during Liver Regeneration
F Meng, H Francis, S Glaser, Y Han, S DeMorrow, A Stokes, D Staloch, J Venter, M White, Y Ueno, LM Reid, G Alpini 		Hepatology 2012
Engineered herpes simplex virus vectors for antitumor therapy and vaccine delivery
DC Gaston, RJ Whitley, JN Parker 		Future Virology 2011
Cytokines in the Genesis and Treatment of Cancer
MA Caligiuri, MT Lotze 		2007
Effect of murine liver cell proliferation on herpes viral behavior: implications for oncolytic viral therapy
KA Delman, JS Zager, A Bhargava, H Petrowsky, S Malhotra, MI Ebright, JJ Bennett, NJ Gusani, DA Kooby, GD Roberts, Y Fong 		Hepatology 2004
A systemic antitumor immune response prevents outgrowth of lung tumors after i.v. rechallenge but is not able to prevent growth of experimental liver tumors
FH van Duijnhoven, RI Aalbers, J Rothbarth, OT Terpstra, PJ Kuppen 		Clinical & Experimental Metastasis 2004
Use of radiolabelled iododeoxyuridine as adjuvant treatment for experimental tumours of the liver
JS Zager, KA Delman, MI Ebright, S Malhotra, S Larson, Y Fong 		British Journal of Surgery 2003
Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection
WR Jarnagin, JS Zager, D Klimstra, KA Delman, S Malhotra, M Ebright, S Little, B DeRubertis, SF Stanziale, M Hezel, H Federoff, Y Fong 		Cancer Gene Therapy 2003
Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer
KA Delman, JS Zager, JJ Bennett, S Malhotra, MI Ebright, PF McAuliffe, MW Halterman, HJ Federoff, Y Fong 		Annals of Surgery 2002
Efficacy of Multiagent Herpes Simplex Virus Amplicon-Mediated Immunotherapy as Adjuvant Treatment for Experimental Hepatic Cancer
KA Delman, JS Zager, JJ Bennett, S Malhotra, MI Ebright, PF McAuliffe, MW Halterman, HJ Federoff, Y Fong 		Annals of Surgery 2002
Prospective Pilot Study of Recombinant Granulocyte-Macrophage Colony-Stimulating Factor and Interferon-γ in Patients With Inoperable Hepatocellular Carcinoma
W Reinisch, M Holub, A Katz, A Herneth, C Lichtenberger, M Schoniger-Hekele, T Waldhoer, G Oberhuber, P Ferenci, A Gangl, C Mueller 		Journal of Immunotherapy 2002
Interleukin 12 secretion enhances antitumor efficacy of oncolytic herpes simplex viral therapy for colorectal cancer
JJ Bennett, S Malhotra, RJ Wong, K Delman, J Zager, M St-Louis, P Johnson, Y Fong 		Annals of Surgery 2001
Interleukin 12 Secretion Enhances Antitumor Efficacy of Oncolytic Herpes Simplex Viral Therapy for Colorectal Cancer
JJ Bennett, S Malhotra, RJ Wong, K Delman, J Zager, M St-Louis, P Johnson, Y Fong 		Annals of Surgery 2001
Reovirus as an Oncolytic Agent Against Experimental Human Malignant Gliomas
ME Wilcox, W Yang, D Senger, NB Rewcastle, DG Morris, PM Brasher, ZQ Shi, RN Johnston, S Nishikawa, PW Lee, PA Forsyth 		JNCI Journal of the National Cancer Institute 2001
Dendritic Cells Transduced with HSV-1 Amplicons Expressing Prostate-Specific Antigen Generate Antitumor Immunity in Mice
RA Willis, WJ Bowers, MJ Turner, TL Fisher, CS Abdul-Alim, DF Howard, HJ Federoff, EM Lord, JG Frelinger 		Human Gene Therapy 2001
Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: Implications for local gene therapy
AD Brooks, B Ng, D Liu, M Brownlee, M Burt, HJ Federoff, Y Fong 		Surgery 2001
Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine
M Toda, RL Martuza, SD Rabkin 		Gene Therapy 2001
A Novel Approach to Cancer Therapy Using an Oncolytic Herpes Virus to Package Amplicons Containing Cytokine Genes
JF Carew, DA Kooby, MW Halterman, SH Kim, HJ Federoff, Y Fong 		Molecular Therapy 2001
Combination Vascular Delivery of Herpes Simplex Oncolytic Viruses and Amplicon Mediated Cytokine Gene Transfer Is Effective Therapy for Experimental Liver Cancer
JS Zager, KA Delman, S Malhotra, MI Ebright, JJ Bennett, T Kates, M Halterman, H Federoff, Y Fong 		Molecular Medicine 2001
Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer
JJ Bennett, J Tjuvajev, P Johnson, M Doubrovin, T Akhurst, S Malholtra, T Hackman, J Balatoni, R Finn, SM Larson, H Federoff, R Blasberg, Y Fong 		Nature Medicine 2001
Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model
WR Jarnagin, K Delman, D Kooby, S Mastorides, J Zager, MF Brennan, LH Blumgart, H Federoff, Y Fong 		Annals of Surgery 2000
Regional muramyl tripeptide phosphatidylethanolamine administration enhances hepatic immune function and tumor surveillance
HM Karpoff, W Jarnagin, K Delman, Y Fong 		Surgery 2000
Neoadjuvant Interleukin-12 Immunogene Therapy Protects Against Cancer Recurrence After Liver Resection in an Animal Model
WR Jarnagin, K Delman, D Kooby, S Mastorides, J Zager, MF Brennan, LH Blumgart, H Federoff, Y Fong 		Annals of Surgery 2000
Antigen-specific immunotherapy for human papillomavirus 16 E7-expressing tumors grown in the liver
CH Chen, KW Suh, H Ji, MA Choti, DM Pardoll, TC Wu 		Journal of Hepatology 2000
Tumor Growth Inhibition by Intratumoral Inoculation of Defective Herpes Simplex Virus Vectors Expressing Granulocyte–Macrophage Colony-Stimulating Factor
M Toda 		Molecular Therapy 2000
Viral-based therapies for liver cancer
JJ Bennett, Y Fong 		HPB : the official journal of the International Hepato Pancreato Biliary Association 2000
Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases
Y Fong, J Fortner, RL Sun, MF Brennan, LH Blumgart 		Annals of Surgery 1999
Clinical Score for Predicting Recurrence After Hepatic Resection for Metastatic Colorectal Cancer
Y Fong, J Fortner, RL Sun, MF Brennan, LH Blumgart 		Annals of Surgery 1999
Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity
M DAngelica, C Tung, P Allen, M Halterman, K Delman, T Delohery, D Klimstra, M Brownlee, H Federoff, Y Fong 		Molecular Medicine 1999
Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207)
DA Kooby, JF Carew, MW Halterman, JE Mack, JR Bertino, LH Blumgart, HJ Federoff, Y Fong 		The FASEB Journal 1999
Eradication of Pre-Established Lymphoma Using Herpes Simplex Virus Amplicon Vectors
M Kutubuddin, HJ Federoff, PM Challita-Eid, M Halterman, B Day, M Atkinson, V Planelles, JD Rosenblatt 		Blood 1999
Pretreatment with IFN-γ Decreases Infectious Complications After Partial Hepatectomy in the Rat
SL Blair, HM Karpoff, C Hodyl, Y Fong 		Journal of Interferon & Cytokine Research 1998
Experimental vaccine strategies for cancer immunotherapy
CH Chen, TC Wu 		Journal of Biomedical Science 1998
Cytokine Gene Therapy for Human Tumors
MD Angelica, Y Fong 		Surgical oncology clinics of North America 1998

Advertisement