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A J Gunn, … , C E Williams, P D Gluckman
Published January 15, 1997
Citation Information: J Clin Invest. 1997;99(2):248-256. https://doi.org/10.1172/JCI119153.
Citation Information: J Clin Invest. 1997;99(2):248-256. https://doi.org/10.1172/JCI119153.
Abstract
Hypothermia has been proposed as a neuroprotective strategy. However, short-term cooling after hypoxia-ischemia is effective only if started immediately during resuscitation. The aim of this study was to determine whether prolonged head cooling, delayed into the late postinsult period, improves outcome from severe ischemia. Unanesthetized near term fetal sheep were subject to 30 min of cerebral ischemia. 90 min later they were randomized to either cooling (n = 9) or sham cooling (n = 7) for 72 h. Intrauterine cooling was induced by a coil around the fetal head, leading initially to a fall in extradural temperature of 5-10 degrees C, and a fall in esophageal temperature of 1.5-3 degrees C. Cooling was associated with mild transient systemic metabolic effects, but not with hypotension or altered fetal heart rate. Cerebral cooling reduced secondary cortical cytotoxic edema (P < 0.001). After 5 d of recovery there was greater residual electroencephalogram activity (-5.2+/-1.6 vs. -15.5+/-1.5 dB, P < 0.001) and a dramatic reduction in the extent of cortical infarction and neuronal loss in all regions assessed (e.g., 40 vs. 99% in the parasagittal cortex, P < 0.001). Selective head cooling, maintained throughout the secondary phase of injury, is noninvasive and safe and shows potential for improving neonatal outcome after perinatal asphyxia.
Authors
A J Gunn, T R Gunn, H H de Haan, C E Williams, P D Gluckman
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Citation information
Citations to this article (443)
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Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model
Y Htun, S Nakamura, Y Nakao, T Mitsuie, M Nakamura, S Yamato, W Jinnai, K Koyano, K Ohta, A Morimoto, T Wakabayashi, M Sugino, K Fujioka, I Kato, S Kondo, S Yasuda, T Miki, M Ueno, T Kusaka |
Scientific Reports | 2019 |
|
Time to start hypothermia after perinatal asphyxia: does it matter?
F Groenendaal |
BMJ paediatrics open | 2019 |
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Early proton magnetic resonance spectroscopy during and after therapeutic hypothermia in perinatal hypoxic–ischemic encephalopathy
AM Lucke, AN Shetty, JL Hagan, A Walton, TD Stafford, ZD Chu, CJ Rhee, JR Kaiser, MS Cortes |
Pediatric Radiology | 2019 |
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Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?
A Davies, G Wassink, L Bennet, AJ Gunn, JO Davidson |
NEURAL REGEN RES | 2019 |
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Differential effects of slow rewarming after cerebral hypothermia on white matter recovery after global cerebral ischemia in near-term fetal sheep
V Draghi, G Wassink, KQ Zhou, L Bennet, AJ Gunn, JO Davidson |
Scientific Reports | 2019 |
|
Protective effects of delayed intraventricular TLR7 agonist administration on cerebral white and gray matter following asphyxia in the preterm fetal sheep
KH Cho, G Wassink, R Galinsky, B Xu, S Mathai, SK Dhillon, LG van den Heuij, JO Davidson, L Weaver-Mikaere, L Bennet, AJ Gunn, M Fraser |
Scientific Reports | 2019 |
|
Core temperature after birth in babies with neonatal encephalopathy in a sub‐Saharan African hospital setting
C EnweronuLaryea, KA Martinello, M Rose, S Manu, CJ Tann, J Meek, K AhorEssel, GB Boylan, NJ Robertson |
The Journal of Physiology | 2019 |
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Disease-directed engineering for physiology-driven treatment interventions in neurological disorders
T Wood, E Nance |
2019 | |
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Predicting the outcomes of targeted temperature management for children with seizures and/or impaired consciousness accompanied by fever without known etiology
T Tanaka, H Nagase, H Yamaguchi, Y Ishida, K Tomioka, M Nishiyama, D Toyoshima, A Maruyama, K Fujita, K Nozu, N Nishimura, H Kurosawa, R Tanaka, K Iijima |
Brain & development | 2019 |
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Pre-emptive opioid sedation during therapeutic hypothermia
P Montaldo, A Vakharia, P Ivain, J Mendoza, V Oliveira, T Markati, S Shankaran, S Thayyil |
Archives of Disease in Childhood - Fetal and Neonatal Edition | 2019 |
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Protection of axonal integrity with 48 or 72 h of cerebral hypothermia in near-term fetal sheep
KQ Zhou, V Draghi, CA Lear, JM Dean, JL Ashton, Y Hou, L Bennet, AJ Gunn, JO Davidson |
Pediatric Research | 2019 |
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Neuroprotective Role of Hypothermia in Hypoxic-ischemic Brain Injury: Combined Therapies using Estrogen
N Toro-Urrego, DJ Vesga-Jiménez, MI Herrera, JP Luaces, F Capani |
Current neuropharmacology | 2019 |
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Limited benefit of slow rewarming after cerebral hypothermia for global cerebral ischemia in near-term fetal sheep
JO Davidson, G Wassink, V Draghi, SK Dhillon, L Bennet, AJ Gunn |
Journal of Cerebral Blood Flow & Metabolism | 2018 |
|
Xenon Combined With Hypothermia in Perinatal Hypoxic-Ischemic Encephalopathy: A Noble Gas, a Noble Mission
AR Amer, DE Oorschot |
Pediatric Neurology | 2018 |
|
The fetus at the tipping point: modifying the outcome of fetal asphyxia: Modulating fetal asphyxia
SK Dhillon, CA Lear, R Galinsky, G Wassink, JO Davidson, S Juul, NJ Robertson, AJ Gunn, L Bennet |
The Journal of Physiology | 2018 |
|
Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy
RC Koehler, ZJ Yang, JK Lee, LJ Martin |
Journal of Cerebral Blood Flow & Metabolism | 2018 |
|
Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period
C Disdier, X Chen, JE Kim, S Threlkeld, B Stonestreet |
Brain Sciences | 2018 |
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Effects of progesterone on the neonatal brain following hypoxia-ischemia
RB Fabres, LA da Rosa, SK de Souza, AL Cecconello, AS Azambuja, EF Sanches, MF Ribeiro, LS de Fraga |
Metabolic Brain Disease | 2018 |
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A working model for hypothermic neuroprotection: Mechanisms of therapeutic hypothermia
G Wassink, JO Davidson, CA Lear, SE Juul, F Northington, L Bennet, AJ Gunn |
The Journal of Physiology | 2018 |
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Evolving changes in fetal heart rate variability and brain injury after hypoxia-ischaemia in preterm fetal sheep: Fetal heart rate variability after hypoxia-ischaemia
K Yamaguchi, CA Lear, MJ Beacom, T Ikeda, AJ Gunn, L Bennet |
The Journal of Physiology | 2018 |
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Asphyxiated neonates who received active therapeutic hypothermia during transport had higher rates of hypocapnia than controls
E Szakmar, K Kovacs, U Meder, G Bokodi, A Szell, Z Somogyvari, AJ Szabo, M Szabo, A Jermendy |
Acta paediatrica (Oslo, Norway : 1992) | 2018 |
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The Role of Diffusion Tensor Imaging in Detecting Hippocampal Injury Following Neonatal Hypoxic-Ischemic Encephalopathy: DTI Evaluation of Hippocampal Injury in HIE
J Salas, N Reddy, E Orru, KA Carson, R Chavez-Valdez, VJ Burton, CE Stafstrom, FJ Northington, TA Huisman |
Journal of neuroimaging : official journal of the American Society of Neuroimaging | 2018 |
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EEG sharp waves are a biomarker of striatal neuronal survival after hypoxia-ischemia in preterm fetal sheep
H Abbasi, PP Drury, CA Lear, AJ Gunn, JO Davidson, L Bennet, CP Unsworth |
Scientific Reports | 2018 |
|
Loss of interneurons and disruption of perineuronal nets in the cerebral cortex following hypoxia-ischaemia in near-term fetal sheep
TM Fowke, R Galinsky, JO Davidson, G Wassink, RN Karunasinghe, JD Prasad, L Bennet, AJ Gunn, JM Dean |
Scientific Reports | 2018 |
|
Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury
SL Parker, M Saxena, J Gowardman, J Lipman, J Myburgh, JA Roberts |
Journal of Critical Care | 2018 |
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Follow-Up for NICU Graduates
H Needelman, BJ Jackson |
2018 | |
|
Relationship between prolonged neural suppression and cerebral hemodynamic dysfunction during hypothermia in asphyxiated piglets
W Jinnai, S Nakamura, K Koyano, S Yamato, T Wakabayashi, Y Htun, Y Nakao, T Iwase, M Nakamura, S Yasuda, M Ueno, T Miki, T Kusaka |
Brain & development | 2018 |
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Targeted Temperature Management in Pediatric Neurocritical Care
G Benedetti, FS Silverstein |
Pediatric Neurology | 2018 |
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Duration of therapeutic hypothermia or targeted temperature management in pediatric cardiac arrest: Seeing through the ice
PM Kochanek, TC Jackson, EL Fink |
Resuscitation | 2018 |
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Improving pregnancy outcomes in humans through studies in sheep
JL Morrison, MJ Berry, KJ Botting, JR Darby, MG Frasch, KL Gatford, DA Giussani, CL Gray, R Harding, EA Herrera, MW Kemp, MC Lock, IC McMillen, TJ Moss, GC Musk, MH Oliver, TR Regnault, CT Roberts, JY Soo, RL Tellam |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2018 |
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Stem cell-based interventions for the prevention of morbidity and mortality following hypoxic-ischaemic encephalopathy in newborn infants
M Bruschettini, O Romantsik, A Moreira, D Ley, B Thébaud |
Cochrane Database of Systematic Reviews | 2018 |
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Therapeutic hypothermia during neonatal transport at Regional Perinatal Centers: active vs. passive cooling
R Lumba, P Mally, M Espiritu, EV Wachtel |
Journal of Perinatal Medicine | 2018 |
|
Ischemic-Reperfusion Injury Increases Matrix Metalloproteinases and Tissue Metalloproteinase Inhibitors in Fetal Sheep Brain
X Chen, A Patra, GB Sadowska, BS Stonestreet |
Developmental Neuroscience | 2018 |
|
EEG for the assessment of neurological function in newborn infants immediately after birth
D Finn, JM OToole, EM Dempsey, GB Boylan |
Archives of Disease in Childhood - Fetal and Neonatal Edition | 2018 |
|
Rapid Alterations in Cerebral White Matter Lipid Profiles After Ischemic-Reperfusion Brain Injury in Fetal Sheep as Demonstrated by MALDI-Mass Spectrometry
GM Gallucci, M Tong, X Chen, BS Stonestreet, A Lin, SM de la Monte |
Pediatric and Developmental Pathology | 2018 |
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Stem cell‐based interventions for the prevention of morbidity and mortality following hypoxic‐ischaemic encephalopathy in newborn infants
Bruschettini M, Romantsik O, Moreira A, Ley D, Thébaud B |
The Cochrane Database of Systematic Reviews | 2018 |
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Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges
LJ Millar, L Shi, A Hoerder-Suabedissen, Z Molnár |
Frontiers in cellular neuroscience | 2017 |
|
Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus
X Chen, V Hovanesian, S Naqvi, YP Lim, R Tucker, JE Donahue, EG Stopa, BS Stonestreet |
Brain, Behavior, and Immunity | 2017 |
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Neutralizing anti-interleukin-1β antibodies reduce ischemia-related interleukin-1β transport across the blood–brain barrier in fetal sheep
A Patra, X Chen, GB Sadowska, J Zhang, YP Lim, JF Padbury, WA Banks, BS Stonestreet |
Neuroscience | 2017 |
|
Connexin hemichannel blockade improves survival of striatal GABA-ergic neurons after global cerebral ischaemia in term-equivalent fetal sheep
R Galinsky, JO Davidson, CA Lear, L Bennet, CR Green, AJ Gunn |
Scientific Reports | 2017 |
|
Immuno-modulator inter-alpha inhibitor proteins ameliorate complex auditory processing deficits in rats with neonatal hypoxic-ischemic brain injury
SW Threlkeld, YP Lim, ML Rue, C Gaudet, BS Stonestreet |
Brain, Behavior, and Immunity | 2017 |
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How long is sufficient for optimal neuroprotection with cerebral cooling after ischemia in fetal sheep?
JO Davidson, V Draghi, S Whitham, SK Dhillon, G Wassink, L Bennet, AJ Gunn |
Journal of Cerebral Blood Flow & Metabolism | 2017 |
|
The Brain and Hypothermia—From Aristotle to Targeted Temperature Management:
PM Kochanek, TC Jackson |
Critical Care Medicine | 2017 |
|
Empfehlung zum Temperaturmanagement nach Atem-Kreislauf-Stillstand und schwerem Schädel-Hirn-Trauma im Kindesalter jenseits der Neonatalperiode: Stellungnahme der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI) und der AG Kinderintensivmedizin des Wissenschaftlichen Arbeitskreises Kinderanästhesie der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin (WAKKA)
S Brenner, C Eich, G Rellensmann, MU Schuhmann, T Nicolai, F Hoffmann |
Der Anaesthesist | 2017 |
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Re-examining the arterial cord blood gas pH screening criteria in neonatal encephalopathy
ZA Vesoulis, SM Liao, R Rao, SB Trivedi, AG Cahill, AM Mathur |
Archives of Disease in Childhood - Fetal and Neonatal Edition | 2017 |
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Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial
AR Laptook, S Shankaran, JE Tyson, B Munoz, EF Bell, RN Goldberg, NA Parikh, N Ambalavanan, C Pedroza, A Pappas, A Das, AS Chaudhary, RA Ehrenkranz, AM Hensman, KP Meurs, LF Chalak, AM Khan, SE Hamrick, GM Sokol, MC Walsh, BB Poindexter, RG Faix, KL Watterberg, ID Frantz, R Guillet, U Devaskar, WE Truog, VY Chock, MH Wyckoff, EC McGowan, DP Carlton, HM Harmon, JE Brumbaugh, CM Cotten, PJ Sánchez, AM Hibbs, RD Higgins |
Journal of the American Medical Association | 2017 |
|
Empfehlung zum Temperaturmanagement nach Atem-Kreislauf-Stillstand und schwerem Schädel-Hirn-Trauma im Kindesalter jenseits der Neonatalperiode: Stellungnahme der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI) und der AG Kinderintensivmedizin des Wissenschaftlichen Arbeitskreises Kinderanästhesie der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin (WAKKA)
S Brenner, C Eich, G Rellensmann, MU Schuhmann, T Nicolai, F Hoffmann |
Monatsschrift Kinderheilkunde | 2017 |
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Writing and Publishing a Scientific Research Paper
SC Parija, V Kate |
2017 | |
|
Feasibility and Safety of Controlled Active Hypothermia Treatment During Transport in Neonates With Hypoxic-Ischemic Encephalopathy:
E Szakmar, K Kovacs, U Meder, A Nagy, A Szell, B Bundzsity, Z Somogyvari, AJ Szabo, M Szabo, A Jermendy |
Pediatric Critical Care Medicine | 2017 |
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The impact of integrated evaluation of hemodynamics using targeted neonatal echocardiography with indices of tissue oxygenation: a new approach
YN Elsayed, R Amer, MM Seshia |
Journal of Perinatology | 2017 |
|
Neurochemical disorders at the hypoxic-ischemic encephalopathy in newborns
T Chuvakova, B Karin |
2017 | |
|
In vivo correlates of thermoregulatory defense in humans: Temporal course of sub-cortical and cortical responses assessed with fMRI: Response of the Human Thermoregulatory Network to Cold
O Muzik, VA Diwadkar |
Human Brain Mapping | 2016 |
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Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia
T Wood, D Osredkar, M Puchades, E Maes, M Falck, T Flatebø, L Walløe, H Sabir, M Thoresen |
Scientific Reports | 2016 |
|
Perinatal inflammation/infection and its association with correction of metabolic acidosis in hypoxic-ischemic encephalopathy
CT Johnson, I Burd, R Raghunathan, FJ Northington, EM Graham |
Journal of Perinatology | 2016 |
|
Rodent Hypoxia–Ischemia Models for Cerebral Palsy Research: A Systematic Review
P Rumajogee, T Bregman, SP Miller, JY Yager, MG Fehlings |
Frontiers in neurology | 2016 |
|
Extending the duration of hypothermia does not further improve white matter protection after ischemia in term-equivalent fetal sheep
JO Davidson, CA Yuill, FG Zhang, G Wassink, L Bennet, AJ Gunn |
Scientific Reports | 2016 |
|
Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy – Creatine prophylaxis and the need for multi-organ protection
SJ Ellery, H Dickinson, M McKenzie, DW Walker |
Neurochemistry International | 2016 |
|
HMGB1 Translocation After Ischemia in the Ovine Fetal Brain
J Zhang, D Klufas, K Manalo, K Adjepong, JO Davidson, G Wassink, L Bennet, AJ Gunn, EG Stopa, K Liu, M Nishibori, BS Stonestreet |
Journal of Neuropathology and Experimental Neurology | 2016 |
|
Therapeutic Hypothermia During Neonatal Transport: Active Cooling Helps Reach the Target
TD Stafford, JL Hagan, CG Sitler, CJ Fernandes, JR Kaiser |
Therapeutic Hypothermia and Temperature Management | 2016 |
|
Recomendaciones terapeuticas del VII Consenso Clinico de SIBEN para la encefalopatia hipoxico-isquemica neonatal
ML Lemus-Varela, A Sola, SG Golombek, H Baquero, CR Davila-Aliaga, D Farina, MV Lima-Rogel, RM Villamayor, F Neira, AN Oviedo-Barrantes, A Garcia-Alix |
NeoReviews | 2016 |
|
Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia: The Hemodynamic Perspective
RE Giesinger, LJ Bailey, P Deshpande, PJ McNamara |
The Journal of Pediatrics | 2016 |
|
Therapeutic hypothermia translates from ancient history in to practice
AJ Gunn, AR Laptook, NJ Robertson, JD Barks, M Thoresen, G Wassink, L Bennet |
Pediatric Research | 2016 |
|
Partial white and grey matter protection with prolonged infusion of recombinant human erythropoietin after asphyxia in preterm fetal sheep
G Wassink, JO Davidson, SK Dhillon, M Fraser, R Galinsky, L Bennet, AJ Gunn |
Journal of Cerebral Blood Flow & Metabolism | 2016 |
|
Using animal models to improve care of neonatal encephalopathy
I Lingam, A Avdic-Belltheus, NJ Robertson |
Archives of Disease in Childhood - Education and Practice | 2016 |
|
Prenatal and Postnatal Determinants of Development
DW Walker |
2016 | |
|
Neutralizing anti-interleukin-1β antibodies modulate fetal blood–brain barrier function after ischemia
X Chen, GB Sadowska, J Zhang, JE Kim, EE Cummings, CA Bodge, YP Lim, O Makeyev, WG Besio, J Gaitanis, SW Threlkeld, WA Banks, BS Stonestreet |
Neurobiology of Disease | 2015 |
|
Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus
J Zhang, GB Sadowska, X Chen, SY Park, JE Kim, CA Bodge, E Cummings, YP Lim, O Makeyev, WG Besio, J Gaitanis, WA Banks, BS Stonestreet |
The FASEB Journal | 2015 |
|
How long is too long for cerebral cooling after ischemia in fetal sheep?
JO Davidson, G Wassink, CA Yuill, FG Zhang, L Bennet, AJ Gunn |
Journal of Cerebral Blood Flow & Metabolism | 2015 |
|
Who should we cool after perinatal asphyxia?
M Thoresen |
Seminars in Fetal and Neonatal Medicine | 2015 |
|
Neuroprotection in Preterm Infants
R Berger, S Söder |
BioMed Research International | 2015 |
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A Randomized Clinical Trial of Therapeutic Hypothermia Mode during Transport for Neonatal Encephalopathy
VP Akula, P Joe, K Thusu, AS Davis, JS Tamaresis, S Kim, TK Shimotake, S Butler, J Honold, M Kuzniewicz, G DeSandre, M Bennett, J Gould, MB Wallenstein, KV Meurs |
The Journal of Pediatrics | 2015 |
|
Adding 5 h delayed xenon to delayed hypothermia treatment improves long-term function in neonatal rats surviving to adulthood
X Liu, J Dingley, E Scull-Brown, M Thoresen |
Pediatric Research | 2015 |
|
Animal studies of neonatal hypothermic neuroprotection have translated well in to practice
AJ Gunn, M Thoresen |
Resuscitation | 2015 |
|
Safety and Effectiveness of Whole Body Cooling Therapy for Neonatal Encephalopathy on Transport
E McNellis, T Fisher, HW Kilbride |
Air Medical Journal | 2015 |
|
Non-additive effects of delayed connexin hemichannel blockade and hypothermia after cerebral ischemia in near-term fetal sheep
JO Davidson, AL Rout, G Wassink, CA Yuill, FG Zhang, CR Green, L Bennet, AJ Gunn |
Journal of Cerebral Blood Flow & Metabolism | 2015 |
|
Interleukin-1β transfer across the blood–brain barrier in the ovine fetus
GB Sadowska, X Chen, J Zhang, YP Lim, EE Cummings, O Makeyev, WG Besio, J Gaitanis, JF Padbury, WA Banks, BS Stonestreet |
Journal of Cerebral Blood Flow & Metabolism | 2015 |
|
Therapeutic hypothermia and hypoxia–ischemia in the term-equivalent neonatal rat: characterization of a translational preclinical model
SD Patel, L Pierce, A Ciardiello, A Hutton, S Paskewitz, E Aronowitz, HU Voss, H Moore, SJ Vannucci |
Pediatric Research | 2015 |
|
Serum Lactate, Brian Magnetic Resonance Imaging and Outcome of Neonatal Hypoxic Ischemic Encephalopathy after Therapeutic Hypothermia
MC Chiang, R Lien, SM Chu, PH Yang, JJ Lin, JF Hsu, RH Fu, KL Lin |
Pediatrics & Neonatology | 2015 |
|
Development of an experimental model of maternal allergic asthma during pregnancy: Allergic asthma during pregnancy in the sheep
VL Clifton, TJ Moss, AL Wooldridge, KL Gatford, B Liravi, D Kim, BS Muhlhausler, JL Morrison, A Davies, RD Matteo, MJ Wallace, RJ Bischof |
The Journal of Physiology | 2015 |
|
Estrogen Effects on Traumatic Brain Injury
G Barreto, E Saraceno, J Gonzalez, R Kolliker, R Castilla, F Capani |
Estrogen Effects on Traumatic Brain Injury | 2015 |
|
Therapeutic Hypothermia for Neonatal Hypoxic–Ischemic Encephalopathy – Where to from Here?
JO Davidson, G Wassink, LG van Heuij, L Bennet, AJ Gunn |
Frontiers in neurology | 2015 |
|
Ontogeny of tight junction protein expression in the ovine cerebral cortex during development
GB Sadowska, N Ahmedli, X Chen, BS Stonestreet |
Neuroscience | 2015 |
|
Modeling Ischemia in the Immature Brain: How Translational Are Animal Models?
C Mallard, ZS Vexler |
Stroke; a journal of cerebral circulation | 2015 |
|
Neonatal hypoxic ischaemic encephalopathy: current and future treatment options
NM Merchant, DV Azzopardi, AD Edwards |
Expert Opinion on Orphan Drugs | 2015 |
|
Antioxidants in Health and Disease
K Becker, F Überall, D Fuchs, J Gostner |
Antioxidants in Health and Disease | 2015 |
|
Subacute Hypoxia-Ischemia and the Timing of Injury in Treatment with Therapeutic Hypothermia
E Kasdorf, A Grunebaum, JM Perlman |
Pediatric Neurology | 2015 |
|
The hospital outcomes compared between the early and late hypothermia-treated groups in neonates
YA Youn, JH Kim, SK Yum, CJ Moon, IG Lee, IK Sung |
Journal of Maternal-Fetal and Neonatal Medicine | 2015 |
|
In vivo Monitoring of Cerebral Hemodynamics in the Immature Rat: Effects of Hypoxia-Ischemia and Hypothermia
EM Buckley, SD Patel, BF Miller, MA Franceschini, SJ Vannucci |
Developmental Neuroscience | 2015 |
|
Human Umbilical Cord Blood Cells Ameliorate Motor Deficits in Rabbits in a Cerebral Palsy Model
A Drobyshevsky, CM Cotten, Z Shi, K Luo, R Jiang, M Derrick, ET Tracy, T Gentry, RN Goldberg, J Kurtzberg, S Tan |
Developmental Neuroscience | 2015 |
|
Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
P Burns, S Kuthiala, G Fecteau, A Desrochers, LD Durosier, M Cao, MG Frasch |
Journal of visualized experiments : JoVE | 2015 |
|
Animal Models of Neurodevelopmental Disorders
JY Yager |
2015 | |
|
Battle of the hemichannels – Connexins and Pannexins in ischemic brain injury
JO Davidson, CR Green, L Bennet, AJ Gunn |
International Journal of Developmental Neuroscience | 2014 |
|
Current Status of Hypothermia for Hypoxemic Ischemia of the Newborn
S Shankaran |
The Indian Journal of Pediatrics | 2014 |
|
Ischemia/Reperfusion-Induced Neovascularization in the Cerebral Cortex of the Ovine Fetus:
D Virgintino, F Girolamo, M Rizzi, N Ahmedli, GB Sadowska, EG Stopa, J Zhang, BS Stonestreet |
Journal of Neuropathology and Experimental Neurology | 2014 |
|
Obstetric antecedents to body-cooling treatment of the newborn infant
DB Nelson, AM Lucke, DD McIntire, PJ Sánchez, KJ Leveno, LF Chalak |
American Journal of Obstetrics and Gynecology | 2014 |
|
The mechanisms and treatment of asphyxial encephalopathy
G Wassink, ER Gunn, PP Drury, L Bennet, AJ Gunn |
Frontiers in neuroscience | 2014 |
|
Maternal treatment with glucocorticoids modulates gap junction protein expression in the ovine fetal brain
GB Sadowska, BS Stonestreet |
Neuroscience | 2014 |
|
Effects of inter-alpha inhibitor proteins on neonatal brain injury: Age, task and treatment dependent neurobehavioral outcomes
SW Threlkeld, CM Gaudet, ME la Rue, E Dugas, CA Hill, YP Lim, BS Stonestreet |
Experimental Neurology | 2014 |
|
Changes in Amplitude-Integrated Electroencephalograms in Piglets during Selective Mild HC after HI
JM Wang, GF Zhang, WH Zhou, ZD Jiang, XM Shao |
Pediatrics & Neonatology | 2014 |
|
Validation of a neuropathology score using quantitative methods to evaluate brain injury in a pig model of hypoxia ischaemia
N Hoque, H Sabir, E Maes, S Bishop, M Thoresen |
Journal of Neuroscience Methods | 2014 |
|
Hypothermia in Hypoxic Ischemic Encephalopathy
JI Arango, K Allred, PD Adelson, P Soni, R Stradleigh, R Wahnoun, C Carballo |
Advances in Pediatrics | 2014 |
|
Neonatal encephalopathy: pre-clinical studies in neuroprotection
SD Patel, L Pierce, AJ Ciardiello, SJ Vannucci |
Biochemical Society Transactions | 2014 |
|
Mechanisms of Hypothermic Neuroprotection
PP Drury, ER Gunn, L Bennet, AJ Gunn |
Clinics in Perinatology | 2014 |
|
The Effect of Combination Treatment of Melatonin and Hypothermia on Hypoxic-Ischemic Brain Injury in Neonatal Rats
JH Park, CS Kim, SL Lee, SR Lee |
Neonatal Medicine | 2014 |
|
Asphyxia and Therapeutic Hypothermia Modulate Plasma Nitrite Concentrations and Carotid Vascular Resistance in Preterm Fetal Sheep
RD Barrett, L Bennet, AB Blood, G Wassink, AJ Gunn |
Reproductive sciences (Thousand Oaks, Calif.) | 2014 |
|
Outcomes in the Era of Therapeutic Hypothermia
AR Laptook, EC McGowan |
NeoReviews | 2014 |
|
Status Epilepticus after Prolonged Umbilical Cord Occlusion Is Associated with Greater Neural Injury Fetal Sheep at Term-Equivalent
PP Drury, JO Davidson, LG van Heuij, G Wassink, ER Gunn, LC Booth, L Bennet, AJ Gunn, O Baud |
PloS one | 2014 |
|
Connexin hemichannel blockade is neuroprotective after, but not during, global cerebral ischemia in near-term fetal sheep
JO Davidson, CR Green, LF Nicholson, L Bennet, AJ Gunn |
Experimental Neurology | 2013 |
|
Therapeutic Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy: Electrographic Seizures and Magnetic Resonance Imaging Evidence of Injury
P Srinivasakumar, J Zempel, M Wallendorf, R Lawrence, T Inder, A Mathur |
The Journal of Pediatrics | 2013 |
|
Therapeutic Hypothermia for Newborns with Hypoxic Ischemic Encephalopathy
M Chang |
Neonatal Medicine | 2013 |
|
Animal Models for the Study of Human Disease
HA Lawson |
Animal Models for the Study of Human Disease | 2013 |
|
Hyperthermia, Inflammation, and Perinatal Brain Injury
E Kasdorf, JM Perlman |
Pediatric Neurology | 2013 |
|
Effects of interleukin-6 on the expression of tight junction proteins in isolated cerebral microvessels from yearling and adult sheep
SS Cohen, M Min, EE Cummings, X Chen, GB Sadowska, S Sharma, BS Stonestreet |
Neuroimmunomodulation | 2013 |
|
Strategies to prevent reperfusion injury to the brain following intrapartum hypoxia–ischemia
E Kasdorf, JM Perlman |
Seminars in Fetal and Neonatal Medicine | 2013 |
|
Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic-ischemic brain injury
I. Lara-Celador, F. Goñi-de-Cerio, Antonia Alvarez, Enrique Hilario |
Neural Regeneration Research | 2013 |
|
Acute on chronic exposure to endotoxin in preterm fetal sheep
S Mathai, LC Booth, JO Davidson, PP Drury, M Fraser, EC Jensen, S George, A Naylor, AJ Gunn, L Bennet |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2013 |
|
Autologous umbilical cord blood cells for newborn infants with hypoxic-ischemic encephalopathy
J Lee |
Cell and Organ Transplantology | 2013 |
|
Hypothermia for neuroprotection in children after cardiopulmonary arrest
B Scholefield, H Duncan, P Davies, FG Smith, K Khan, GD Perkins, K Morris |
Cochrane Database of Systematic Reviews | 2013 |
|
Cooling for newborns with hypoxic ischaemic encephalopathy
SE Jacobs, M Berg, R Hunt, WO Tarnow-Mordi, TE Inder, PG Davis |
Cochrane Database of Systematic Reviews | 2013 |
|
Connexin hemichannel blockade improves outcomes in a model of fetal ischemia
JO Davidson, CR Green, LF Nicholson, SJ O'Carroll, M Fraser, L Bennet, AJ Gunn |
Annals of Neurology | 2012 |
|
Deleterious Effects of High Dose Connexin 43 Mimetic Peptide Infusion After Cerebral Ischaemia in Near-Term Fetal Sheep
JO Davidson, CR Green, LF Nicholson, L Bennet, AJ Gunn |
International journal of molecular sciences | 2012 |
|
Brain Resuscitation in the Drowning Victim
AA Topjian, RA Berg, JJ Bierens, CM Branche, RS Clark, H Friberg, CW Hoedemaekers, M Holzer, LM Katz, JT Knape, PM Kochanek, V Nadkarni, JG Hoeven, DS Warner |
Neurocritical Care | 2012 |
|
Therapeutic Hypothermia for Neonatal Encephalopathy
S Shankaran |
Current Treatment Options in Neurology | 2012 |
|
Stabilization and Transport of the High-Risk Infant
GA Woodward, R Kirsch, MS Trautman, ME Kleinman, G Wernovsky, BS Marino |
Avery s Diseases of the Newborn | 2012 |
|
Neurology
G Barone |
The Cat | 2012 |
|
Limited predictive value of early changes in EEG spectral power for neural injury after asphyxia in preterm fetal sheep
MJ Keogh, PP Drury, L Bennet, JO Davidson, S Mathai, ER Gunn, LC Booth, AJ Gunn |
Pediatric Research | 2012 |
|
Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat
ML Dalen, X Liu, M Elstad, EM Løberg, OD Saugstad, T Rootwelt, M Thoresen |
Pediatric Research | 2012 |
|
Usefulness of serum lipid peroxide as a diagnostic test for hypoxic ischemic encephalopathy in the full-term neonate
JC León, R Cervantes-Munguía, C Vásquez, MA Higareda-Almaraz, A Bravo-Cuellar, L González-López |
Journal of Perinatology | 2012 |
|
Effects of hypothermia on NSE and S-100 protein levels in CSF in neonates following hypoxic/ischaemic brain damage : Effects of hypothermia on NSE and S-100 level
J Sun, J Li, G Cheng, B Sha, W Zhou |
Acta Paediatrica | 2012 |
|
Cell therapy for neonatal hypoxia-ischemia and cerebral palsy
L Bennet, S Tan, LV Heuij, M Derrick, F Groenendaal, F Bel, S Juul, SA Back, F Northington, NJ Robertson, C Mallard, AJ Gunn |
Annals of Neurology | 2012 |
|
Swaiman's Pediatric Neurology
GM Enns, TM Cowan, O Klein, S Packman |
Swaiman's Pediatric Neurology | 2012 |
|
Rescuing the neonatal brain from hypoxic injury with autologous cord blood
Y Liao, M Cotten, S Tan, J Kurtzberg, MS Cairo |
Bone Marrow Transplantation | 2012 |
|
Intrauterine temperature during intrapartum amnioinfusion: a prospective observational study: Intrauterine temperature during amnioinfusion
TM Tomlinson, C Schaecher, Y Sadovsky, G Gross |
BJOG: An International Journal of Obstetrics & Gynaecology | 2012 |
|
Comparison of Three Hypothermic Target Temperatures for the Treatment of Hypoxic Ischemia: mRNA Level Responses of Eight Genes in the Piglet Brain
L Olson, S Faulkner, K Lundströmer, A Kerenyi, D Kelen, M Chandrasekaran, U Ådén, L Olson, X Golay, H Lagercrantz, NJ Robertson, D Galter |
Translational Stroke Research | 2012 |
|
Passive cooling during transport of asphyxiated term newborns
D O'Reilly, M Labrecque, M O'Melia, J Bacic, A Hansen, JS Soul |
Journal of Perinatology | 2012 |
|
Neurology: Neonatology Questions and Controversies
AR Laptook |
Neurology: Neonatology Questions and Controversies | 2012 |
|
Nevroprotektiv behandling ved fødselsasfyksi
AL Solevåg, B Nakstad |
Tidsskrift for Den norske legeforening | 2012 |
|
Hypoxic-ischemic Encephalopathy and Novel Strategies for Neuroprotection
S Shankaran |
Clinics in Perinatology | 2012 |
|
Therapeutic hypothermia during neonatal transport: data from the California Perinatal Quality Care Collaborative (CPQCC) and California Perinatal Transport System (CPeTS) for 2010
VP Akula, JB Gould, AS Davis, A Hackel, J Oehlert, KP van Meurs |
Journal of Perinatology | 2012 |
|
Therapeutic Hypothermia to Treat Hypoxic Ischemic Encephalopathy in Newborns: IMPLICATIONS FOR NURSES
L Merrill |
Nursing for Women's Health | 2012 |
|
Effects of combination therapy using hypothermia and erythropoietin in a rat model of neonatal hypoxia-ischemia
AY Fang, FF Gonzalez, RA Sheldon, DM Ferriero |
Pediatric Research | 2012 |
|
Ischemia-reperfusion impairs blood-brain barrier function and alters tight junction protein expression in the ovine fetus
X Chen, SW Threlkeld, EE Cummings, I Juan, O Makeyev, WG Besio, J Gaitanis, WA Banks, GB Sadowska, BS Stonestreet |
Neuroscience | 2012 |
|
Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)
L Filippi, P Fiorini, M Daniotti, S Catarzi, S Savelli, C Fonda, L Bartalena, A Boldrini, M Giampietri, R Scaramuzzo, P Papoff, FD Balzo, A Spalice, G Marca, S Malvagia, ML Bona, G Donzelli, F Tinelli, G Cioni, T Pisano, M Falchi, R Guerrini |
BMC Pediatrics | 2012 |
|
Ontogeny and the effects of in utero brain ischemia on interleukin-1β and interleukin-6 protein expression in ovine cerebral cortex and white matter
GB Sadowska, SW Threlkeld, A Flangini, S Sharma, BS Stonestreet |
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience | 2012 |
|
Hypothermic neuroprotection
AJ Gunn, M Thoresen |
NeuroRX | 2012 |
|
Preterm neonatal cardiovascular instability: Does understanding the fetus help evaluate the newborn?
L Bennet, LC Booth, PP Drury, JS Quaedackers, AJ Gunn |
Clinical and Experimental Pharmacology and Physiology | 2012 |
|
Implementation and Conduct of Therapeutic Hypothermia for Perinatal Asphyxial Encephalopathy in the UK – Analysis of National Data
D Azzopardi, B Strohm, L Linsell, A Hobson, E Juszczak, JJ Kurinczuk, P Brocklehurst, AD Edwards, I Reiss |
PloS one | 2012 |
|
Early Antioxidant Treatment and Delayed Hypothermia After Hypoxia–Ischemia Have No Additive Neuroprotection in Newborn Pigs
X Ni, ZJ Yang, B Wang, EL Carter, AC Larson, LJ Martin, RC Koehler |
Anesthesia & Analgesia | 2012 |
|
Brain temperature: heat production, elimination and clinical relevance
G Bertolizio, L Mason, B Bissonnette |
Pediatric Anesthesia | 2011 |
|
Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury
D Alonso-Alconada, A Alvarez, E Hilario |
Neuroscience Bulletin | 2011 |
|
Current Management of the Infant Who Presents with Neonatal Encephalopathy
EV Wachtel, KD Hendricks-Muñoz |
Current Problems in Pediatric and Adolescent Health Care | 2011 |
|
Neonatal Hypothermia: A Method to Provide Neuroprotection After Hypoxic Ischemic Encephalopathy
KM Newnam, DL DeLoach |
Newborn and Infant Nursing Reviews | 2011 |
|
Presente y futuro de la neuroprotección con hipotermia
D Blanco |
Anales de Pediatría | 2011 |
|
Neuroprotección con hipotermia en el recién nacido con encefalopatía hipóxico-isquémica. Guía de estándares para su aplicación clínica
D Blanco, A García-Alix, E Valverde, V Tenorio, M Vento, F Cabañas |
Anales de Pediatría | 2011 |
|
Hypothermia for neuroprotection in children after cardiopulmonary arrest
B Scholefield, K Morris, H Duncan, P Davies, FG Smith, K Khan, B Scholefield |
Cochrane Database of Systematic Reviews Protocols | 2011 |
|
Effects of selective head cooling on cerebral blood flow and metabolism in newborn piglets after hypoxia–ischemia
G Cheng, J Sun, L Wang, X Shao, W Zhou |
Early Human Development | 2011 |
|
White Matter Protection with Insulin-Like Growth Factor 1 and Hypothermia Is Not Additive after Severe Reversible Cerebral Ischemia in Term Fetal Sheep
S George, L Bennet, L Weaver-Mikaere, M Fraser, J Bouwmans, S Mathai, SJ Skinner, AJ Gunn |
Developmental Neuroscience | 2011 |
|
Whole body hypothermia broadens the therapeutic window of intranasally administered IGF-1 in a neonatal rat model of cerebral hypoxia-ischemia
S Lin, PG Rhodes, Z Cai |
Brain Research | 2011 |
|
Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments
KA Allen, DH Brandon |
Newborn and infant nursing reviews : NAINR | 2011 |
|
Filling the evidence gap: How can we improve the outcome of neonatal encephalopathy in the next 10years?
O Iwata, S Iwata |
Brain and Development | 2011 |
|
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani |
Fetal and Neonatal Physiology | 2011 |
|
Pitfalls in the quest of neuroprotectants for the perinatal brain
P Gressens, VL Verche, M Fraser, CI Rousset, L Schwendimann, L Bennet, SA George, X Wang, C Mallard, BC Tilley, P Dournaud, AJ Gunn, H Hagberg, SW Levison |
Developmental Neuroscience | 2011 |
|
Comparative effects of glucose- and mannitol-induced osmolar stress on blood-brain barrier function in ovine fetuses and lambs
BS Stonestreet, GB Sadowska, RC Hanumara, M Petrache, KH Petersson, CS Patlak |
Journal of Cerebral Blood Flow & Metabolism | 2011 |
|
Maternal dexamethasone and EEG hyperactivity in preterm fetal sheep: Dexamethasone and fetal EEG
JO Davidson, JS Quaedackers, SA George, AJ Gunn, L Bennet |
The Journal of Physiology | 2011 |
|
Therapeutic Hypothermia for Management of Neonatal Asphyxia: What Nurses Need to Know
N Chirinian, N Mann |
Critical Care Nurse | 2011 |
|
Hypothermia for hypoxic–ischemic encephalopathy
CM Cotten, S Shankaran |
Expert Review of Obstetrics & Gynecology | 2010 |
|
Hypothermia increases interleukin-6 and interleukin-10 in juvenile endotoxemic mice*
CR Stewart, JP Landseadel, MJ Gurka, KD Fairchild |
Pediatric Critical Care Medicine | 2010 |
|
Cost-Effectiveness of Therapeutic Hypothermia to Treat Neonatal Encephalopathy
DA Regier, S Petrou, J Henderson, O Eddama, N Patel, B Strohm, P Brocklehurst, AD Edwards, D Azzopardi |
Value in Health | 2010 |
|
Selective Head Cooling with Mild Systemic Hypothermia after Neonatal Hypoxic-Ischemic Encephalopathy: A Multicenter Randomized Controlled Trial in China
W Zhou, G Cheng, X Shao, X Liu, R Shan, D Zhuang, C Zhou, L Du, Y Cao, Q Yang, L Wang |
The Journal of Pediatrics | 2010 |
|
Mechanisms of hypothermic neuroprotection
PP Drury, L Bennet, AJ Gunn |
Seminars in Fetal and Neonatal Medicine | 2010 |
|
Hypothermia: a systematic review and meta-analysis of clinical trials
PS Shah |
Seminars in Fetal and Neonatal Medicine | 2010 |
|
Patient selection and prognostication with hypothermia treatment
M Thoresen |
Seminars in Fetal and Neonatal Medicine | 2010 |
|
Therapeutic hypothermia translates to the NICU
AJ Gunn, L Bennet |
Seminars in Fetal and Neonatal Medicine | 2010 |
|
Protocols for High-Risk Pregnancies
RD Higgins |
Protocols for High-Risk Pregnancies | 2010 |
|
Neonatal Encephalopathy: Treatment With Hypothermia
S Shankaran |
NeoReviews | 2010 |
|
Chain of Brain Preservation—A concept to facilitate early identification and initiation of hypothermia to infants at high risk for brain injury
T Takenouchi, M Cuaycong, G Ross, M Engel, JM Perlman |
Resuscitation | 2010 |
|
Therapeutic hypothermia following intrapartum hypoxia-ischemia. An advisory statement from the Neonatal Task Force of the International Liaison Committee on Resuscitation
JM Perlman, P Davis, J Wyllie, J Kattwinkel |
Resuscitation | 2010 |
|
Long-Term Neuroprotective Effect of Postischemic Hypothermia in a Neonatal Rat Model of Severe Hypoxic Ischemic Encephalopathy: A Comparative Study on the Duration and Depth of Hypothermia
BS Lee, CW Woo, ST Kim, KS Kim |
Pediatric Research | 2010 |
|
Hypothermia for the treatment of infants with hypoxic–ischemic encephalopathy
RH Pfister, RF Soll |
Journal of Perinatology | 2010 |
|
Therapeutic hypothermia for newborn infants with hypoxic-ischaemic encephalopathy
SE Jacobs, WO Tarnow-Mordi |
Journal of Paediatrics and Child Health | 2010 |
|
Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy
A Roka, D Azzopardi |
Early Human Development | 2010 |
|
Potential biomarkers for hypoxic–ischemic encephalopathy
L Bennet, L Booth, AJ Gunn |
Seminars in fetal & neonatal medicine | 2010 |
|
Therapeutic hypothermia with immunosuppressive drugs for a comatose renal transplant patient who survived out-of-hospital cardiac arrest
R Zushi, H Hazui, M Hoshiga, Y Yagi, T Goto, T Mori, M Kawakami, I Nishihara, H Kobata, Y Ohishi, H Akimoto |
Journal of Cardiology Cases | 2010 |
|
Évaluation d’un protocole de prise en charge de l’encéphalopathie anoxo-ischémique du nouveau-né par hypothermie
N Delnard, F Cneude, S Hamelin, G Emeriaud, F Berne-Audéoud, P Andrini, T Debillon |
Archives de Pédiatrie | 2010 |
|
Neuroprotection par hypothermie contrôlée dans l’encéphalopathie hypoxique-ischémique du nouveau-né à terme
E Saliba, T Debillon |
Archives de Pédiatrie | 2010 |
|
Neonatal ECMO Study of Temperature (NEST) - a randomised controlled trial
DJ Field, R Firmin, DV Azzopardi, F Cowan, E Juszczak, P Brocklehurst |
BMC Pediatrics | 2010 |
|
Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep
GB Sadowska, SN Malaeb, BS Stonestreet |
American journal of physiology. Heart and circulatory physiology | 2010 |
|
The neural and vascular effects of killed Su- Streptococcus pyogenes (OK-432) in preterm fetal sheep
L Bennet, RV Cowie, PR Stone, R Barrett, AS Naylor, AB Blood, AJ Gunn |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2010 |
|
Early Induction of Hypothermia During Cardiac Arrest Improves Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Who Undergo Emergency Cardiopulmonary Bypass and Percutaneous Coronary Intervention
K Nagao, K Kikushima, K Watanabe, E Tachibana, Y Tominaga, K Tada, M Ishii, N Chiba, A Kasai, T Soga, M Matsuzaki, K Nishikawa, Y Tateda, H Ikeda, T Yagi |
Circulation journal : official journal of the Japanese Circulation Society | 2010 |
|
Neuroprotection in the newborn infant
FF Gonzalez, DM Ferriero |
Clinics in Perinatology | 2009 |
|
Therapeutic hypothermia on neonatal transport: 4-year experience in a single NICU
K Fairchild, D Sokora, J Scott, S Zanelli |
Journal of perinatology : official journal of the California Perinatal Association | 2009 |
|
Ontogeny and the effects of exogenous and endogenous glucocorticoids on tight junction protein expression in ovine cerebral cortices
AR Duncan, GB Sadowska, BS Stonestreet |
Brain Research | 2009 |
|
Hypothermia for hypoxic ischemic encephalopathy in infants > or =36 weeks
RD Higgins, S Shankaran |
Early Human Development | 2009 |
|
Fetal hypoxia insults and patterns of brain injury: insights from animal models
AJ Gunn, L Bennet |
Clinics in Perinatology | 2009 |
|
Neonatal encephalopathy: treatment with hypothermia
S Shankaran |
Journal of Neurotrauma | 2009 |
|
Therapeutic hypothermia: applications in pediatric cardiac arrest
PM Kochanek, EL Fink, MJ Bell, H Bayir, RS Clark |
Journal of Neurotrauma | 2009 |
|
Ontogeny of connexin 32 and 43 expression in the cerebral cortices of ovine fetuses, newborns, and adults
GB Sadowska, EG Stopa, BS Stonestreet |
Brain Research | 2009 |
|
Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation
ML Dalen, E Frøyland, OD Saugstad, TE Mollnes, T Rootwelt |
Brain Research | 2009 |
|
The Discovery of Hypothermic Neural Rescue Therapy for Perinatal Hypoxic-Ischemic Encephalopathy
AD Edwards |
Seminars in Pediatric Neurology | 2009 |
|
Use of Therapeutic Hypothermia for Term Infants with Hypoxic-Ischemic Encephalopathy
AR Laptook |
Pediatric Clinics of North America | 2009 |
|
The Chilling Details: Hypoxic-Ischemic Encephalopathy
MT Verklan |
The Journal of Perinatal & Neonatal Nursing | 2009 |
|
Neuroprotective interventions: is it too late?
DD Jenkins, E Chang, I Singh |
Journal of child neurology | 2009 |
|
Physiologic and Pharmacologic Effects of Therapeutic Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy
S Zanelli, K Fairchild |
Newborn and Infant Nursing Reviews | 2009 |
|
Hypothermia for hypoxic–ischemic brain injury
A Parish, J Bhatia |
Journal of Maternal-Fetal and Neonatal Medicine | 2009 |
|
Analysis of Neuronal, Glial, Endothelial, Axonal and Apoptotic Markers Following Moderate Therapeutic Hypothermia and Anesthesia in the Developing Piglet Brain
P Gressens, J Dingley, F Plaisant, H Porter, L Schwendimann, C Verney, J Tooley, M Thoresen |
Brain Pathology | 2008 |
|
Sustained depression of brainstem auditory electrophysiology during the first months in term infants after perinatal asphyxia
ZD Jiang, DM Brosi, XM Shao, AR Wilkinson |
Clinical Neurophysiology | 2008 |
|
Strategies for the management of neonatal hypoxic–ischemic brain injury
JM Perlman |
Expert Review of Obstetrics & Gynecology | 2008 |
|
Post-resuscitation strategies to avoid ongoing injury following intrapartum hypoxia–ischemia
A Stola, J Perlman |
Seminars in Fetal and Neonatal Medicine | 2008 |
|
Therapeutics for neonatal brain injury
FF Gonzalez, DM Ferriero |
Pharmacology & Therapeutics | 2008 |
|
Extracellular amino acids and lipid peroxidation products in periventricular white matter during and after cerebral ischemia in preterm fetal sheep
M Fraser, L Bennet, PL van Zijl, TJ Mocatta, CE Williams, PD Gluckman, CC Winterbourn, AJ Gunn |
Journal of Neurochemistry | 2008 |
|
Brain-regulated metabolic suppression during hibernation: a neuroprotective mechanism for perinatal hypoxia–ischemia
TI Nathaniel |
International Journal of Stroke | 2008 |
|
A review of selective hypothermia in the management of traumatic brain injury
E Christian, G Zada, G Sung, SL Giannotta |
Neurosurgical FOCUS | 2008 |
|
Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units
T Hoehn, G Hansmann, C Bührer, G Simbruner, AJ Gunn, J Yager, M Levene, SE Hamrick, S Shankaran, M Thoresen |
Resuscitation | 2008 |
|
Cochrane Review: Cooling for newborns with hypoxic ischaemic encephalopathy
SE Jacobs, R Hunt, WO Tarnow-Mordi, TE Inder, PG Davis |
Evidence-Based Child Health: A Cochrane Review Journal | 2008 |
|
Delayed Hypothermia as Selective Head Cooling or Whole Body Cooling Does Not Protect Brain or Body in Newborn Pig Subjected to Hypoxia-Ischemia
M Karlsson, JR Tooley, S Satas, CE Hobbs, E Chakkarapani, J Stone, H Porter, M Thoresen |
Pediatric Research | 2008 |
|
Hypothermia Therapy for Cardiac Arrest in Pediatric Patients
JS Hutchison, DR Doherty, JP Orlowski, N Kissoon |
Pediatric Clinics of North America | 2008 |
|
Hypothermia for Hypoxic-Ischemic Encephalopathy
R Sahni, UM Sanocka |
Clinics in Perinatology | 2008 |
|
Neonatology: Questions and Controversies Series: Neurology
AR Laptook |
Neonatology: Questions and Controversies Series: Neurology | 2008 |
|
The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: A randomised controlled trial
D Azzopardi, P Brocklehurst, D Edwards, H Halliday, M Levene, M Thoresen, A Whitelaw |
BMC Pediatrics | 2008 |
|
Selective hypothermia: an experimental study on traumatic brain injury in rats
AE Dvilevicius, MN Prandini |
Arquivos de Neuro-Psiquiatria | 2008 |
|
Effects of maternal treatment with corticosteroids on tight junction protein expression in the cerebral cortex of the ovine fetus with and without exposure to in utero brain ischemia
SN Malaeb, GB Sadowska, BS Stonestreet |
Brain Research | 2007 |
|
Theoretical limits on brain cooling by external head cooling devices
AL Sukstanskii, DA Yablonskiy |
European Journal of Applied Physiology | 2007 |
|
Induced cerebral hypothermia reduces post-hypoxic loss of phenotypic striatal neurons in preterm fetal sheep
S George, J Scotter, JM Dean, L Bennet, HJ Waldvogel, J Guan, RL Faull, AJ Gunn |
Experimental Neurology | 2007 |
|
Systemic hypothermia to decrease morbidity of hypoxic-ischemic brain injury
RA Polin, TM Randis, R Sahni |
Journal of Perinatology | 2007 |
|
Hypothermia as a Treatment for Birth Asphyxia
S Shankaran, AR Laptook |
Clinical Obstetrics and Gynecology | 2007 |
|
Head Cooling for Neonatal Encephalopathy: The State of the Art
AJ Gunn, PD Gluckman |
Clinical Obstetrics and Gynecology | 2007 |
|
A hypoxiás-ischaemiás encephalopathia kezelése mérsékelt, teljestest-hypothermia alkalmazásával érett újszülöttekben – biztonságossági vizsgálat Magyarországon
A Róka, E Bodrogi, M Szabó, T Machay |
Orvosi Hetilap | 2007 |
|
Lack of influence of mild hypothermia on amplitude integrated-electroencephalography in neonates receiving extracorporeal membrane oxygenation
M Horan, D Azzopardi, AD Edwards, RK Firmin, D Field |
Early Human Development | 2007 |
|
Gerard W. Ostheimer Lecture 2006: What’s New in Obstetric Anaesthesia? Contributions from the 2005 literature
R Fernando |
International Journal of Obstetric Anesthesia | 2007 |
|
Neonatal Induced Hypothermia
AL Thoerner |
Newborn and Infant Nursing Reviews | 2007 |
|
The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep: Head cooling and preterm hypoxia
L Bennet, V Roelfsema, S George, JM Dean, BS Emerald, AJ Gunn |
The Journal of Physiology | 2007 |
|
A systematic review of cooling for neuroprotection in neonates with hypoxic ischemic encephalopathy – are we there yet?
SM Schulzke, S Rao, SK Patole |
BMC Pediatrics | 2007 |
|
Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep
L Bennet, V Roelfsema, JM Dean, G Wassink, GG Power, EC Jensen, AJ Gunn |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2007 |
|
Differential Effects of Hypothermia on Early and Late Epileptiform Events After Severe Hypoxia in Preterm Fetal Sheep
L Bennet, JM Dean, G Wassink, AJ Gunn |
Journal of neurophysiology | 2007 |
|
Safety of Deep Hypothermia in Treating Neonatal Asphyxia
G Compagnoni, C Bottura, G Cavallaro, G Cristofori, G Lista, F Mosca |
Neonatology | 2007 |
|
Neonatal resuscitation
SH Kapoor, D Kapoor |
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine | 2007 |
|
Therapeutic hypothermia following perinatal asphyxia
AD Edwards, DV Azzopardi |
Archives of disease in childhood. Fetal and neonatal edition | 2006 |
|
Intervention strategies for neonatal hypoxic-ischemic cerebral injury
JM Perlman |
Clinical Therapeutics | 2006 |
|
Suppression of post-hypoxic-ischemic EEG transients with dizocilpine is associated with partial striatal protection in the preterm fetal sheep
JM Dean, SA George, G Wassink, AJ Gunn, L Bennet |
Neuropharmacology | 2006 |
|
Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit
ZL Lin, HM Yu, J Lin, SQ Chen, ZQ Liang, ZY Zhang |
Journal of Perinatology | 2006 |
|
Some like it cool: hypothermia for newborn infants with hypoxic ischemic encephalopathy
OD Saugstad |
Journal of Perinatology | 2006 |
|
Therapeutic hypothermia
AG Alzaga, M Cerdan, J Varon |
Resuscitation | 2006 |
|
Changes in BAER amplitudes after perinatal asphyxia during the neonatal period in term infants
ZD Jiang, XM Shao, AR Wilkinson |
Brain and Development | 2006 |
|
Combination of Systemic Hypothermia and N-acetylcysteine Attenuates Hypoxic-Ischemic Brain Injury in Neonatal Rats
M Jatana, I Singh, AK Singh, D Jenkins |
Pediatric Research | 2006 |
|
Hypothermia and perinatal asphyxia: Executive summary of the National Institute of Child Health and Human Development workshop
RD Higgins, TN Raju, J Perlman, DV Azzopardi, LR Blackmon, RH Clark, AD Edwards, DM Ferriero, PD Gluckman, AJ Gunn, SE Jacobs, DJ Eicher, AH Jobe, AR Laptook, MH LeBlanc, C Palmer, S Shankaran, RF Soll, AR Stark, M Thoresen, J Wyatt |
The Journal of Pediatrics | 2006 |
|
Modest Hypothermia as a Neuroprotective Strategy in High-Risk Term Infants
M Speer, JM Perlman |
Clinics in Perinatology | 2006 |
|
Endogenous α2-adrenergic receptor-mediated neuroprotection after severe hypoxia in preterm fetal sheep
JM Dean, AJ Gunn, G Wassink, S George, L Bennet |
Neuroscience | 2006 |
|
Brief Update on Animal Models of Hypoxic-Ischemic Encephalopathy and Neonatal Stroke
FJ Northington |
ILAR journal / National Research Council, Institute of Laboratory Animal Resources | 2006 |
|
Post-hypoxic hypoperfusion is associated with suppression of cerebral metabolism and increased tissue oxygenation in near-term fetal sheep: Increased cerebral oxygenation after asphyxia
EC Jensen, L Bennet, CJ Hunter, GC Power, AJ Gunn |
The Journal of Physiology | 2006 |
|
Transient NMDA receptor-mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep: NMDA receptor-mediated hypoperfusion in fetal sheep
JM Dean, AJ Gunn, G Wassink, L Bennet |
Experimental Physiology | 2006 |
|
Hypothermic neuroprotection
AJ Gunn, M Thoresen |
Neurotherapeutics | 2006 |
|
Models of Seizures and Epilepsy
EA Cavalheiro, MG Naffah-Mazzacoratti, LE Mello, JP Leite |
Models of Seizures and Epilepsy | 2006 |
|
Topical Review: Role of Instrumented Fetal Sheep Preparations in Defining the Pathogenesis of Human Periventricular White-Matter Injury
SA Back, A Riddle, AR Hohimer |
Journal of child neurology | 2006 |
|
Handbook on Drowning
JJ Bierens |
2006 | |
|
The Cochrane Database of Systematic Reviews (Protocol)
VG da Silva, GA Romito, JM Aldrighi, A Cranney, GH Gomes, A Tirlone, FE Pustiglioni, VG da Silva |
The Cochrane Database of Systematic Reviews (Protocol) | 2005 |
|
Significant head cooling can be achieved while maintaining normothermia in the newborn piglet
JR Tooley, RC Eagle, S Satas, M Thoresen |
Archives of disease in childhood. Fetal and neonatal edition | 2005 |
|
Induced hypothermia: A novel neuroprotective treatment of neonatal encephalopathy after intrapartum hypoxia-ischemia
J Perlman |
Current Treatment Options in Neurology | 2005 |
|
Therapeutic hypothermia for hypoxic–ischaemic encephalopathy in the newborn infant: review
M Thoresen, A Whitelaw |
Current Opinion in Neurology | 2005 |
|
Therapeutic hypothermia: from lab to NICU
AJ Gunn, M Battin, PD Gluckman, TR Gunn, L Bennet |
Journal of Perinatal Medicine | 2005 |
|
Effects of rapid rewarming on cerebral nitric oxide production and cerebral hemodynamics after hypothermia therapy for kainic acid-induced seizures in immature rabbits
Y Takei, D Sunohara, Y Nishikawa, C Nagashima, M Tachibana, T Takami, T Miyajima, A Hoshika |
Pediatrics International | 2005 |
|
Rapid Brain Cooling by Hypothermic Retrograde Jugular Vein Flush
YS Wen, MS Huang, MT Lin, CH Lee |
The Journal of Trauma: Injury, Infection, and Critical Care | 2005 |
|
Cerebral oxygenation during postasphyxial seizures in near-term fetal sheep
H Gonzalez, CJ Hunter, L Bennet, GG Power, AJ Gunn |
Journal of Cerebral Blood Flow & Metabolism | 2005 |
|
Effect of hypothermia on transthoracic defibrillation in a swine model
BJ Rhee, Y Zhang, KA Boddicker, LR Davies, RE Kerber |
Resuscitation | 2005 |
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Apoptosis in perinatal hypoxic–ischemic brain injury: How important is it and should it be inhibited?
FJ Northington, EM Graham, LJ Martin |
Brain Research Reviews | 2005 |
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Pathophysiology of an hypoxic–ischemic insult during the perinatal period
JW Calvert, JH Zhang |
Neurological Research | 2005 |
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Depth of delayed cooling alters neuroprotection pattern after hypoxia-ischemia
O Iwata, JS Thornton, MW Sellwood, S Iwata, Y Sakata, MA Noone, FE O'Brien, A Bainbridge, ED Vita, G Raivich, D Peebles, F Scaravilli, EB Cady, R Ordidge, JS Wyatt, NJ Robertson |
Annals of Neurology | 2005 |
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Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy
S Shankaran, AR Laptook, RA Ehrenkranz, JE Tyson, SA McDonald, EF Donovan, AA Fanaroff, WK Poole, LL Wright, RD Higgins, NN Finer, WA Carlo, S Duara, W Oh, CM Cotten, DK Stevenson, BJ Stoll, JA Lemons, R Guillet, AH Jobe |
New England Journal of Medicine | 2005 |
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Central Nervous System Injury and Neuroprotection
A Madan, SE Hamrick, DM Ferriero |
Avery s Diseases of the Newborn | 2005 |
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Time for a cool head—neuroprotection becomes a reality
JS Wyatt, NJ Robertson |
Early Human Development | 2005 |
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Prolonged hypothermia protects neonatal rat brain against hypoxic-ischemia by reducing both apoptosis and necrosis
A Ohmura, W Nakajima, A Ishida, N Yasuoka, M Kawamura, S Miura, G Takada |
Brain and Development | 2005 |
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Epileptiform Activity During Rewarming from Moderate Cerebral Hypothermia in the Near-Term Fetal Sheep
LC Gerrits, MR Battin, L Bennet, H Gonzalez, AJ Gunn |
Pediatric Research | 2005 |
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Cortical electroencephalogram suppression is associated with post-ischemic cortical injury in 0.65 gestation fetal sheep
M Fraser, L Bennet, M Gunning, C Williams, PD Gluckman, S George, AJ Gunn |
Developmental Brain Research | 2005 |
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Combination of Early Perinatal Factors to Identify Near-Term and Term Neonates for Neuroprotection
AJ Talati, W Yang, K Yolton, SB Korones, HS Bada |
Journal of Perinatology | 2005 |
|
Moderate hypothermia in neonatal encephalopathy: Efficacy outcomes
DJ Eicher, CL Wagner, LP Katikaneni, TC Hulsey, WT Bass, DA Kaufman, MJ Horgan, S Languani, JJ Bhatia, LM Givelichian, K Sankaran, JY Yager |
Pediatric Neurology | 2005 |
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Cochrane Database of Systematic Reviews
L Hooper, C Bartlett, GD Smith, S Ebrahim, L Hooper |
Cochrane Database of Systematic Reviews | 2004 |
|
Window of Opportunity of Cerebral Hypothermia for Postischemic White Matter Injury in the Near-Term Fetal Sheep
V Roelfsema, L Bennet, S George, D Wu, J Guan, M Veerman, AJ Gunn |
Journal of Cerebral Blood Flow & Metabolism | 2004 |
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Intestinal ischemia reperfusion injury and multisystem organ failure
A Pierro, S Eaton |
Seminars in Pediatric Surgery | 2004 |
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Rapid and selective cerebral hypothermia achieved using a cooling helmet
H Wang, W Olivero, G Lanzino, W Elkins, J Rose, D Honings, M Rodde, J Burnham, D Wang |
Journal of Neurosurgery | 2004 |
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Brain-stem auditory impairment during the neonatal period in term infants after asphyxia: dynamic changes in brain-stem auditory evoked response to clicks of different rates
ZD Jiang, R Yin, XM Shao, AR Wilkinson |
Clinical Neurophysiology | 2004 |
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Postischemic mild hypothermia reduces neurotransmitter release and astroglial cell proliferation during reperfusion after asphyxial cardiac arrest in rats
S Hachimi-Idrissi, AV Hemelrijck, A Michotte, I Smolders, S Sarre, G Ebinger, L Huyghens, Y Michotte |
Brain Research | 2004 |
|
Brain injury in the term infant
JM Perlman |
Seminars in Perinatology | 2004 |
|
Hypoxic–ischemic brain injury in the term infant-current concepts
L Shalak, JM Perlman |
Early Human Development | 2004 |
|
Effects of Exogenous Glucose on Brain Ischemia in Ovine Fetuses
KH Petersson, H Pinar, EG Stopa, GB Sadowska, RC Hanumara, BS Stonestreet |
Pediatric Research | 2004 |
|
A Pilot investigation of mild hypothermia in neonates receiving extracorporeal membrane oxygenation (ECMO)
M Horan, S Ichiba, RK Firmin, HM Killer, D Edwards, D Azzopardi, R Hodge, S Kotecha, D Field |
The Journal of Pediatrics | 2004 |
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The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation
EJ Parkinson, PA Townsend, A Stephanou, DS Latchman, S Eaton, A Pierro |
Journal of Pediatric Surgery | 2004 |
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Therapeutic Hypothermia
S Dixon, W ONeill |
Therapeutic Hypothermia | 2004 |
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Fetal heart rate variability and brain stem injury after asphyxia in preterm fetal sheep
S George, AJ Gunn, JA Westgate, C Brabyn, J Guan, L Bennet |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
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Differential Changes in Peripheraland Central Components of the Brain Stem Auditory Evoked Potentials during the Neonatal Period Interm Infants after Perinatal Hypoxia-Ischemia
ZD Jiang, X Xu, XM Shao, R Yin, AR Wilkinson |
The Annals of otology, rhinology, and laryngology | 2004 |
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Insulin-like growth factor-1 and post-ischemic brain injury
J Guan, L Bennet, PD Gluckman, AJ Gunn |
Progress in Neurobiology | 2003 |
|
The injury response in the term newborn brain: can we neuroprotect?
SE Hamrick, DM Ferriero |
Current Opinion in Neurology | 2003 |
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Brain temperature in newborn piglets under selective head cooling with minimal systemic hypothermia
O Iwata, S Iwata, M Tamura, T Nakamura, M Sugiura, Y Ogiso |
Pediatrics International | 2003 |
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Effects of Hypothermia on Energy Metabolism in Mammalian Central Nervous System
M Erecinska, M Thoresen, IA Silver |
Journal of Cerebral Blood Flow & Metabolism | 2003 |
|
Challenge of conducting trials of neuroprotection in the asphyxiated term infant
S Shankaran, A Laptook |
Seminars in Perinatology | 2003 |
|
Effects of antenatal steroids on ischemic brain injury in near-term ovine fetuses
CM Elitt, GB Sadowska, EG Stopa, H Pinar, KH Petersson, BS Stonestreet |
Early Human Development | 2003 |
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Long-Term Neuroprotective Effects of Hypothermia on Neonatal Hypoxic-Ischemic Brain Injury in Rats, Assessed by Auditory Brainstem Response
T Tomimatsu, H Fukuda, M Endoh, J Mu, T Kanagawa, T Hosono, T Kanzaki, K Doi, T Kubo, Y Murata |
Pediatric Research | 2003 |
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Hypothermia for 24 Hours After Asphyxic Cardiac Arrest in Piglets Provides Striatal Neuroprotection That Is Sustained 10 Days After Rewarming
DM Agnew, RC Koehler, AM Guerguerian, DH Shaffner, RJ Traystman, LJ Martin, RN Ichord |
Pediatric Research | 2003 |
|
Time Course of Brainstem Pathophysiology during First Month in Term Infants after Perinatal Asphyxia, Revealed by MLS BAER Latencies and Intervals
ZD Jiang, DM Brosi, J Wang, X Xu, GQ Chen, XM Shao, AR Wilkinson |
Pediatric Research | 2003 |
|
Effect of Mild Hypothermia and Hypoxia on Blood Flow and Oxygen Consumption of the Fetal Sheep Brain
H Chihara, AB Blood, CJ Hunter, GG Power |
Pediatric Research | 2003 |
|
Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells
H Gibbons, TA Sato, M Dragunow |
Molecular Brain Research | 2003 |
|
Perinatal brain damage—from pathophysiology to prevention
A Jensen, Y Garnier, J Middelanis, R Berger |
European Journal of Obstetrics & Gynecology and Reproductive Biology | 2003 |
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Extreme marginal donor: severe hypothermia as a rare preservation condition for explantable organs—a case report
A Brolese, M Bassanello, U Cillo, FA Ciarleglio, A Vitale, P Feltracco, I Tiberio, P Boccagni, G Zanus, F D’Amico, C Ruffolo, M Senzolo, BD D’Amico |
Transplantation Proceedings | 2003 |
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Hypothermia throughout intestinal ischaemia-reperfusion injury attenuates lung neutrophil infiltration
S Vinardi, A Pierro, EJ Parkinson, P Vejchapipat, G Stefanutti, L Spitz, S Eaton |
Journal of Pediatric Surgery | 2003 |
|
Clinical trials of treatments after perinatal asphyxia
A Whitelaw, M Thoresen |
Current Opinion in Pediatrics | 2002 |
|
Drug-induced hypothermia begun 5 minutes after injury with a poly(adenosine 5′-diphosphate-ribose) polymerase inhibitor reduces hypoxic brain injury in rat pups*
Y Feng, MH LeBlanc |
Critical Care Medicine | 2002 |
|
Hyperbaric oxygenation prevented brain injury induced by hypoxia–ischemia in a neonatal rat model
JW Calvert, W Yin, M Patel, A Badr, G Mychaskiw, AD Parent, JH Zhang |
Brain Research | 2002 |
|
Delayed Postischemic Hypothermia Improves Long-Term Behavioral Outcome after Cerebral Hypoxia-Ischemia in Neonatal Rats
BP Wagner, J Nedelcu, E Martin |
Pediatric Research | 2002 |
|
White Matter Injury after Cerebral Ischemia in Ovine Fetuses
KH Petersson, H Pinar, EG Stopa, RA Faris, GB Sadowska, RC Hanumara, BS Stonestreet |
Pediatric Research | 2002 |
|
The emerging role of induced hypothermia in the management of acute stroke
VL Feigin, CS Anderson, A Rodgers, NE Anderson, AJ Gunn |
Journal of Clinical Neuroscience | 2002 |
|
The effects of temperature on hypoxic-ischemic brain injury
AR Laptook, RJ Corbett |
Clinics in Perinatology | 2002 |
|
Tolérance de l’hypothermie thérapeutique modérée : son effet sur le système cardiovasculaire néonatal et notamment la circulation pulmonaire et intestinale
M Zayek, F Eyal |
Archives de Pédiatrie | 2002 |
|
Mild hypothermia in neurologic emergency: An update
J Inamasu, K Ichikizaki |
Annals of Emergency Medicine | 2002 |
|
Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury
KL Arvin, BH Han, Y Du, SZ Lin, SM Paul, DM Holtzman |
Annals of Neurology | 2002 |
|
Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective
JR Tooley, S Satas, H Porter, IA Silver, M Thoresen |
Annals of Neurology | 2002 |
|
Perinatal Brain Damage: Underlying Mechanisms and Neuroprotective Strategies
R Berger, Y Garnier, A Jensen |
Journal of the Society for Gynecologic Investigation | 2002 |
|
Insulin-like Growth Factor-1 Reduces Postischemic White Matter Injury in Fetal Sheep
J Guan, L Bennet, S George, D Wu, HJ Waldvogel, PD Gluckman, RL Faull, PS Crosier, AJ Gunn |
Journal of Cerebral Blood Flow & Metabolism | 2001 |
|
Clinical experience with therapeutic hypothermia in asphyxiated infants
A Whitelaw, M Thoresen |
Developmental Medicine & Child Neurology | 2001 |
|
Effective Selective Head Cooling during Posthypoxic Hypothermia in Newborn Piglets
M Thoresen, M Simmonds, S Satas, J Tooley, IA Silver |
Pediatric Research | 2001 |
|
Twenty-Four Hours of Mild Hypothermia in Unsedated Newborn Pigs Starting after a Severe Global Hypoxic-Ischemic Insult Is Not Neuroprotective
M Thoresen, S Satas, EM Løberg, A Whitelaw, D Acolet, C Lindgren, J Penrice, N Robertson, E Haug, PA Steen |
Pediatric Research | 2001 |
|
Perinatal Asphyxia: A Clinical Review, Including Research with Brain Hypothermia
NE Flavin |
Neonatal Network The Journal of Neonatal Nursing | 2001 |
|
Hypoxic-ischemic brain injury in the newborn: pathophysiology and potential strategies for intervention
PD Gluckman, CS Pinal, AJ Gunn |
Seminars in Neonatology | 2001 |
|
Moderate hypothermia ameliorates liver energy failure after intestinal ischaemia-reperfusion in anaesthetised rats
P Vejchapipat, SR Williams, E Proctor, V Lauro, L Spitz, A Pierro |
Journal of Pediatric Surgery | 2001 |
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Influence of mild hypothermia on delayed mitochondrial dysfunction after transient intrauterine ischemia in the immature rat brain
A Nakai, Y Shibazaki, Y Taniuchi, A Oya, H Asakura, S Kuroda, T Koshino, T Araki |
Developmental Brain Research | 2001 |
|
Is temperature important in delivery room resuscitation?
AJ Gunn, L Bennet |
Seminars in Neonatology | 2001 |
|
Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs: Low CMRgl in Fetal Lambs After Cord Occlusion
K Thorngren-Jerneck, D Ley, L Hellström-Westas, E Hernandez-Andrade, G Lingman, T Ohlsson, G Oskarsson, E Pesonen, A Sandell, SE Strand, O Werner, K Maršal |
Journal of Neuroscience Research | 2001 |
|
Effects of Mild Hypothermia on Metabolic Disturbances in Fetal Hippocampal Slices After Oxygen/Glucose Deprivation Depend on Depth and Time Delay of Cooling
Y Garnier, D Pfeiffer, A Jensen, R Berger |
Journal of the Society for Gynecologic Investigation | 2001 |
|
Electrophysiological Properties of CA1 Neurons Protected by Postischemic Hypothermia in Gerbils
H Dong, F Moody-Corbett, F Colbourne, Q Pittman, D Corbett |
Stroke; a journal of cerebral circulation | 2001 |
|
Perinatal brain injury
R Berger, Y Garnier |
Journal of Perinatal Medicine | 2000 |
|
Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium
MA Dommergues, J Patkai, JC Renauld, P Evrard, P Gressens |
Annals of Neurology | 2000 |
|
Resuscitative Hypothermia Protects the Neonatal Rat Brain from Hypoxic-Ischemic Injury
J Nedelcu, MA Klein, A Aguzzi, E Martin |
Brain Pathology | 2000 |
|
Persistent Neuroprotection with Prolonged Postischemic Hypothermia in Adult Rats Subjected to Transient Middle Cerebral Artery Occlusion
D Corbett, M Hamilton, F Colbourne |
Experimental Neurology | 2000 |
|
Cerebral hypothermia for prevention of brain injury following perinatal asphyxia
AJ Gunn |
Current Opinion in Pediatrics | 2000 |
|
Coupling of Cerebral Blood Flow and Oxygen Metabolism in Infant Pigs During Selective Brain Hypothermia
B Walter, R Bauer, G Kuhnen, H Fritz, U Zwiener |
Journal of Cerebral Blood Flow & Metabolism | 2000 |
|
Relationship between Local Cerebral Blood Flow and Metabolism during Mild and Moderate Hypothermia in Rats
T Frietsch, P Krafft, A Piepgras, C Lenz, W Kuschinsky, KF Waschke |
Anesthesiology | 2000 |
|
Numerical Modeling of Temperature Distributions within the Neonatal Head
GM van Leeuwen, JW Hand, JJ Lagendijk, DV Azzopardi, AD Edwards |
Pediatric Research | 2000 |
|
Early predictors of adverse outcome in term infants with post-asphyxial hypoxic ischaemic encephalopathy
VC Toh |
Acta Paediatrica | 2000 |
|
Cooling the newborn after asphyxia — physiological and experimental background and its clinical use
M Thoresen |
Seminars in Neonatology | 2000 |
|
Selection of babies for intervention after birth asphyxia
F Groenendaal, LS de Vries |
Seminars in Neonatology | 2000 |
|
Mechanisms of perinatal brain injury
TE Inder, JJ Volpe |
Seminars in Neonatology | 2000 |
|
Pathophysiology of perinatal brain damage
R Berger, Y Garnier |
Brain Research Reviews | 1999 |
|
The cardiovascular and cerebrovascular responses of the immature fetal sheep to acute umbilical cord occlusion
L Bennet, S Rossenrode, MI Gunning, PD Gluckman, AJ Gunn |
The Journal of Physiology | 1999 |
|
Role of adenosine in regulation of brain temperature in fetal sheep
S Suzuki, GG Power |
American Journal of Obstetrics and Gynecology | 1999 |
|
An international network for evaluating neuroprotective therapy after severe birth asphyxia
MI Levene, DJ Evans, S Mason, J Brown |
Seminars in Perinatology | 1999 |
|
Cerebral Hypothermia Is Not Neuroprotective When Started after Postischemic Seizures in Fetal Sheep
AJ Gunn, L Bennet, MI Gunning, PD Gluckman, TR Gunn |
Pediatric Research | 1999 |
|
A Limited Interval of Delayed Modest Hypothermia for Ischemic Brain Resuscitation Is Not Beneficial in Neonatal Swine
AR Laptook, RJ Corbett, DK Burns, R Sterett |
Pediatric Research | 1999 |
|
Selective neuroprotective effects with insulin-like growth factor-1 in phenotypic striatal neurons following ischemic brain injury in fetal sheep
J Guan, L Bennet, S George, HJ Waldvogel, RL Faull, PD Gluckman, H Keunen, AJ Gunn |
Neuroscience | 1999 |
|
Glycine antagonist and NO synthase inhibitor protect the developing mouse brain against neonatal excitotoxic lesions
S Marret, C Bonnier, JM Raymackers, A Delpech, P Evrard, P Gressens |
Pediatric Research | 1999 |
|
Role of the Cerebrovascular and Metabolic Responses in the Delayed Phases of Injury After Transient Cerebral Ischemia in Fetal Sheep
RA Raad, WK Tan, L Bennet, AJ Gunn, SL Davis, PD Gluckman, BM Johnston, CE Williams |
Stroke; a journal of cerebral circulation | 1999 |
|
Hypothermic neural rescue treatment: from laboratory to cotside?
AD Edwards, D Azzopardi |
Archives of disease in childhood. Fetal and neonatal edition | 1998 |
|
Treatment of hypoxic-ischaemic brain damage by moderate hypothermia
AD Edwards, JS Wyatt, M Thoresen |
Archives of disease in childhood. Fetal and neonatal edition | 1998 |
|
Hypothermia during or after severe perinatal asphyxia prevents increase in cyclic GMP-related nitric oxide levels in the newborn rat striatum
CF Loidl, JD Vente, MM van Ittersum, EH van Dijk, JS Vles, HW Steinbusch, CE Blanco |
Brain Research | 1998 |
|
Fetal Brain Injury Following Prolonged Hypoxemia and Placental Insufficiency: A Review
S Rees, C Mallard, S Breen, M Stringer, M Cock, R Harding |
Comparative Biochemistry and Physiology - Part A Molecular & Integrative Physiology | 1998 |
|
The `pharmacology' of neuronal rescue with cerebral hypothermia
AJ Gunn, TR Gunn |
Early Human Development | 1998 |
|
Protective Effects of Moderate Hypothermia after Neonatal Hypoxia-Ischemia: Short- and Long-Term Outcome
E Bona, H Hagberg, EM Løberg, R Bågenholm, M Thoresen |
Pediatric Research | 1998 |
|
Maturational Change in the Cortical Response to Hypoperfusion Injury in the Fetal Sheep
K Reddy, C Mallard, J Guan, K Marks, L Bennet, M Gunning, A Gunn, P Gluckman, C Williams |
Pediatric Research | 1998 |
|
Pharmacological strategies for the prevention of perinatal brain damage
AJ Gunn, PD Gluckman |
Seminars in Neonatology | 1998 |
|
Keeping a cool head, post-hypoxic hypothermia–an old idea revisited
M Thoresen, J Wyatt |
Acta Paediatrica | 1997 |
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