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Citations to this article

Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
A J Gunn, … , C E Williams, P D Gluckman
A J Gunn, … , C E Williams, P D Gluckman
Published January 15, 1997
Citation Information: J Clin Invest. 1997;99(2):248-256. https://doi.org/10.1172/JCI119153.
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Research Article Article has an altmetric score of 33

Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.

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Abstract

Hypothermia has been proposed as a neuroprotective strategy. However, short-term cooling after hypoxia-ischemia is effective only if started immediately during resuscitation. The aim of this study was to determine whether prolonged head cooling, delayed into the late postinsult period, improves outcome from severe ischemia. Unanesthetized near term fetal sheep were subject to 30 min of cerebral ischemia. 90 min later they were randomized to either cooling (n = 9) or sham cooling (n = 7) for 72 h. Intrauterine cooling was induced by a coil around the fetal head, leading initially to a fall in extradural temperature of 5-10 degrees C, and a fall in esophageal temperature of 1.5-3 degrees C. Cooling was associated with mild transient systemic metabolic effects, but not with hypotension or altered fetal heart rate. Cerebral cooling reduced secondary cortical cytotoxic edema (P < 0.001). After 5 d of recovery there was greater residual electroencephalogram activity (-5.2+/-1.6 vs. -15.5+/-1.5 dB, P < 0.001) and a dramatic reduction in the extent of cortical infarction and neuronal loss in all regions assessed (e.g., 40 vs. 99% in the parasagittal cortex, P < 0.001). Selective head cooling, maintained throughout the secondary phase of injury, is noninvasive and safe and shows potential for improving neonatal outcome after perinatal asphyxia.

Authors

A J Gunn, T R Gunn, H H de Haan, C E Williams, P D Gluckman

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 Total
Citations: 5 11 15 10 16 24 18 24 15 14 26 16 12 29 17 24 15 16 16 18 20 14 14 12 12 12 9 8 1 443
Citation information
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Citations to this article in year 2008 (16)

Title and authors Publication Year
Analysis of Neuronal, Glial, Endothelial, Axonal and Apoptotic Markers Following Moderate Therapeutic Hypothermia and Anesthesia in the Developing Piglet Brain
P Gressens, J Dingley, F Plaisant, H Porter, L Schwendimann, C Verney, J Tooley, M Thoresen
Brain Pathology 2008
Sustained depression of brainstem auditory electrophysiology during the first months in term infants after perinatal asphyxia
ZD Jiang, DM Brosi, XM Shao, AR Wilkinson
Clinical Neurophysiology 2008
Strategies for the management of neonatal hypoxic–ischemic brain injury
JM Perlman
Expert Review of Obstetrics & Gynecology 2008
Post-resuscitation strategies to avoid ongoing injury following intrapartum hypoxia–ischemia
A Stola, J Perlman
Seminars in Fetal and Neonatal Medicine 2008
Therapeutics for neonatal brain injury
FF Gonzalez, DM Ferriero
Pharmacology & Therapeutics 2008
Extracellular amino acids and lipid peroxidation products in periventricular white matter during and after cerebral ischemia in preterm fetal sheep
M Fraser, L Bennet, PL van Zijl, TJ Mocatta, CE Williams, PD Gluckman, CC Winterbourn, AJ Gunn
Journal of Neurochemistry 2008
Brain-regulated metabolic suppression during hibernation: a neuroprotective mechanism for perinatal hypoxia–ischemia
TI Nathaniel
International Journal of Stroke 2008
A review of selective hypothermia in the management of traumatic brain injury
E Christian, G Zada, G Sung, SL Giannotta
Neurosurgical FOCUS 2008
Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units
T Hoehn, G Hansmann, C Bührer, G Simbruner, AJ Gunn, J Yager, M Levene, SE Hamrick, S Shankaran, M Thoresen
Resuscitation 2008
Cochrane Review: Cooling for newborns with hypoxic ischaemic encephalopathy
SE Jacobs, R Hunt, WO Tarnow-Mordi, TE Inder, PG Davis
Evidence-Based Child Health: A Cochrane Review Journal 2008
Delayed Hypothermia as Selective Head Cooling or Whole Body Cooling Does Not Protect Brain or Body in Newborn Pig Subjected to Hypoxia-Ischemia
M Karlsson, JR Tooley, S Satas, CE Hobbs, E Chakkarapani, J Stone, H Porter, M Thoresen
Pediatric Research 2008
Hypothermia Therapy for Cardiac Arrest in Pediatric Patients
JS Hutchison, DR Doherty, JP Orlowski, N Kissoon
Pediatric Clinics of North America 2008
Hypothermia for Hypoxic-Ischemic Encephalopathy
R Sahni, UM Sanocka
Clinics in Perinatology 2008
Neonatology: Questions and Controversies Series: Neurology
AR Laptook
Neonatology: Questions and Controversies Series: Neurology 2008
The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: A randomised controlled trial
D Azzopardi, P Brocklehurst, D Edwards, H Halliday, M Levene, M Thoresen, A Whitelaw
BMC Pediatrics 2008
Selective hypothermia: an experimental study on traumatic brain injury in rats
AE Dvilevicius, MN Prandini
Arquivos de Neuro-Psiquiatria 2008

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