The identification of human inflammatory cells that express inducible nitric oxide synthase and the clarification of the role of inducible nitric oxide synthase in human infectious or inflammatory processes have been elusive. In neutrophil-enriched fractions from urine, we demonstrate a 43-fold increase in nitric oxide synthase activity in patients with urinary tract infections compared with that in neutrophil-enriched fractions from noninfected controls. Partially purified inducible nitric oxide synthase is primarily membrane associated, calcium independent, and inhibited by arginine analogues with a rank order consistent with that of purified human inducible nitric oxide synthase. Molecular, biochemical, and immunocytochemical evidence unequivocally identifies inducible nitric oxide synthase as the major nitric oxide synthase isoform found in neutrophils isolated from urine during urinary tract infections. Elevated inducible nitric oxide synthase activity and elevated nitric oxide synthase protein measured in patients with urinary tract infections and treated with antibiotics does not decrease until 6-10 d of antibiotic treatment. The extended elevation of neutrophil inducible nitric oxide synthase during urinary tract infections may have both antimicrobial and proinflammatory functions.
M A Wheeler, S D Smith, G García-Cardeña, C F Nathan, R M Weiss, W C Sessa
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Clinical Orthopaedics and Related Research® | 2002 |
Oxygen/Nitrogen Radicals: Cell Injury and Disease
V Vallyathan, X Shi, V Castranova |
2002 | |
Handbook of Antioxidants
K Meissner, W Siems, O Sommerburg, M Leichsenring |
Handbook of Antioxidants | 2001 |
Acquired Disorders of Phagocyte Function Complicating Medical and Surgical Illnesses
G Engelich, DG Wright, KL Hartshorn |
Clinical Infectious Diseases | 2001 |
Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney
M Poljakovic, ML Svensson, C Svanborg, K Johansson, B Larsson, K Persson |
Kidney International | 2001 |
Nitric Oxide Synthase Activity in Neutrophils From Patients With Localized Aggressive Periodontitis
K Shibata, ML Warbington, BJ Gordon, H Kurihara, TE van Dyke |
Journal of Periodontology | 2001 |
Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent
WY Tse, J Williams, A Pall, M Wilkes, CO Savage, D Adu |
Kidney International | 2001 |
Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model
MA Wheeler, JH Yoon, LE Olsson, RM Weiss |
European Journal of Pharmacology | 2001 |
Effect of adhesion on inducible nitric oxide synthase (iNOS) production in purified human neutrophils
JL Webb, JM Polak, TJ Evans |
Clinical & Experimental Immunology | 2001 |
Dexamethasone impairs pulmonary defence against Pseudomonas aeruginosa through suppressing iNOS gene expression and peroxynitrite production in mice
S Satoh, K Oishi, A Iwagaki, M Senba, T Akaike, M Akiyama, N Mukaida, KM Atsushima, T Nagatake |
Clinical & Experimental Immunology | 2001 |
Effects of the synthetic selectin inhibitor TBC1269 on tissue damage during acute Mannheimia haemolytica-induced pneumonia in neonatal calves
ZA Radi, JM Caverly, RA Dixon, KA Brogden, MR Ackermann |
American Journal of Veterinary Research | 2001 |
Cytotoxic effects of peroxynitrite, polymorphonuclear neutrophils, free-radical scavengers, inhibitors of myeloperoxidase, and inhibitors of nitric oxide synthase on bovine mammary secretory epithelial cells
TK Ledbetter, MJ Paape, LW Douglass |
American Journal of Veterinary Research | 2001 |
INDUCIBLE NITRIC OXIDE SYNTHASE IN THE BLADDER OF SPINAL CORD INJURED PATIENTS WITH A CHRONIC INDWELLING URINARY CATHETER
BM Wall, RR Dmochowski, M Malecha, T Mangold, MA Cooke |
The Journal of Urology | 2001 |
Anti-inflammatory effects of macrolide antibiotics
O Čulić, V Eraković, MJ Parnham |
European Journal of Pharmacology | 2001 |
The physiological role and pharmacological potential of nitric oxide in neutrophil activation
R Armstrong |
International Immunopharmacology | 2001 |
Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages
T Kuncewicz, P Balakrishnan, MB Snuggs, BC Kone |
American journal of physiology. Renal physiology | 2001 |
Bactericidal Activity of Human Eosinophilic Granulocytes against Escherichia coli
AD O'Brien, T Persson, P Andersson, M Bodelsson, M Laurell, J Malm, A Egesten |
Infection and immunity | 2001 |
Nitric Oxide Measurements during Endotoxemia
V Brovkovych, LW Dobrucki, S Brovkovych, I Dobrucki, L Kalinowski, F Kiechle, T Malinski |
Clinical chemistry | 2001 |
Neutrophils: Molecules, Functions and Pathophysiological Aspects
V Witko-Sarsat, P Rieu, B Descamps-Latscha, P Lesavre, L Halbwachs-Mecarelli |
Laboratory Investigation | 2000 |
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients
SD Smith, MA Wheeler, MI Lorber, RM Weiss |
Kidney International | 2000 |
Interaction between lung surfactant and nitric oxide production by alveolar macrophages stimulated by group B streptococci
RK Bouhafs, C Jarstrand |
Pediatric Pulmonology | 2000 |
New directions in allergic diseases: Mechanism-based anti-inflammatory therapies
PJ Barnes |
Journal of Allergy and Clinical Immunology | 2000 |
Compartmentalised inducible nitric-oxide synthase activity in septic shock
D Annane, S Sanquer, V Sébille, A Faye, D Djuranovic, JC Raphaël, P Gajdos, E Bellissant |
The Lancet | 2000 |
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
C Nathan, MU Shiloh |
Proceedings of the National Academy of Sciences | 2000 |
A neutrophil-derived anti-infective molecule: bactericidal/permeability-increasing protein
O Levy |
Antimicrobial agents and chemotherapy | 2000 |
Nitrite generation and antioxidant effects during neutrophil apoptosis
NL Misso, CD Peacock, DN Watkins, PJ Thompson |
Free radical biology & medicine | 2000 |
Nitric Oxide Regulates the Aggregation of Stimulated Human Neutrophils
T Forslund, HM Nilsson, T Sundqvist |
Biochemical and Biophysical Research Communications | 2000 |
Modulation of Polymorphonuclear Leukocytes Function by Nitric Oxide
S Sethi, M Dikshit |
Thrombosis Research | 2000 |
Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine
UH Mellqvist, M Hansson, M Brune, C Dahlgren, S Hermodsson, K Hellstrand |
Blood | 2000 |
New treatments for asthma
PJ Barnes |
European Journal of Internal Medicine | 2000 |
Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents
O Levy |
Blood | 2000 |
Enhancement of Neonatal Innate Defense: Effects of Adding an N-Terminal Recombinant Fragment of Bactericidal/Permeability-Increasing Protein on Growth and Tumor Necrosis Factor-Inducing Activity of Gram-Negative Bacteria Tested in Neonatal Cord Blood Ex Vivo
RN Moore, O Levy, RB Sisson, J Kenyon, E Eichenwald, AB Macone, D Goldmann |
Infection and immunity | 2000 |
The role of 6R-tetrahydrobiopterin in the nervous system
K Koshimura, Y Murakami, J Tanaka, Y Kato |
Progress in Neurobiology | 2000 |
Activation of Nuclear Factor κB and Induction of Inducible Nitric Oxide Synthase by Ureaplasma urealyticum in Macrophages
EI Tuomanen, YH Li, ZQ Yan, JS Jensen, K Tullus, A Brauner |
Infection and immunity | 2000 |
l-Arginine supplementation increases mesangial cell injury and subsequent tissue fibrosis in experimental glomerulonephritis
H Peters, WA Border, NA Noble |
Kidney International | 1999 |
MAST CELLS MEDIATE THE SEVERITY OF EXPERIMENTAL CYSTITIS IN MICE
DE Bjorling, TJ Jerde, MJ Zine, BW Busser, MR Saban, R Saban |
The Journal of Urology | 1999 |
Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase
MU Shiloh, JD MacMicking, S Nicholson, JE Brause, S Potter, M Marino, F Fang, M Dinauer, C Nathan |
Immunity | 1999 |
DIRECT DETECTION OF NITRIC OXIDE IN RAT URINARY BLADDER DURING ISCHEMIA-REPERFUSION
M Saito, I Miyagawa |
The Journal of Urology | 1999 |
The nitric oxide pathway in pig isolated calyceal smooth muscle
CE Iselin, L Ny, D Mastrangelo, E Felley-Bosco, B Larsson, P Alm, KE Andersson |
Neurourology and Urodynamics | 1999 |
A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
GE Korting, SD Smith, MA Wheeler, RM Weiss, HE Foster |
The Journal of Urology | 1999 |
INDUCIBLE NITRIC OXIDE SYNTHASE WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER
HS Swana, SD Smith, PL Perrotta, N Saito, MA Wheeler, RM Weiss |
The Journal of Urology | 1999 |
Role of nitric oxide on the replication of viral haemorrhagic septicemia virus (VHSV), a fish rhabdovirus
C Tafalla, A Figueras, B Novoa |
Veterinary Immunology and Immunopathology | 1999 |
Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway
SR Thomas, R Stocker |
Redox Report | 1999 |
Localized increase in nitric oxide production and the expression of nitric oxide synthase isoforms in rat uterus with experimental intrauterine infection
L Fang, B J Nowicki, Y L Dong, C Yallampalli |
American Journal of Obstetrics and Gynecology | 1999 |
Morphological and Biochemical Investigation of Nitric Oxide Synthase and Related Enzymes in the Rat and Pig Urothelium
K Persson, M Poljakovic, K Johansson, B Larsson |
Journal of Histochemistry & Cytochemistry | 1999 |
Advances in Bladder Research
LS Baskin, SW Hayward |
1999 | |
Gamma Interferon Treatment of Patients with Chronic Granulomatous Disease Is Associated with Augmented Production of Nitric Oxide by Polymorphonuclear Neutrophils
A Åhlin, G Lärfars, G Elinder, J Palmblad, H Gyllenhammar |
Clinical and diagnostic laboratory immunology | 1999 |
Activation of Nitric Oxide Release and Oxidative Metabolism by Leukotrienes B4, C4, and D4 in Human Polymorphonuclear Leukocytes
G Lärfars, F Lantoine, MA Devynck, J Palmblad, H Gyllenhammar |
Blood | 1999 |
Expression of Human Inducible Nitric Oxide Synthase Gene in T-Cell Lines Infected With Human T-Cell Leukemia Virus Type-I and Primary Adult T-Cell Leukemia Cells
N Mori, Y Nunokawa, Y Yamada, S Ikeda, M Tomonaga, N Yamamoto |
Blood | 1999 |
Assessment of the quality of dialysate
LK Lee, TW Meyer, AS Pollock, DH Lovett |
Journal of Clinical Investigation | 1998 |
Resistance of filarial nematode parasites to oxidative stress
ME Selkirk, VP Smith, GR Thomas, K Gounaris |
International Journal for Parasitology | 1998 |
Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules
JP Eiserich, RP Patel, VB O’Donnell |
Molecular Aspects of Medicine | 1998 |
Inducible nitric oxide synthase in human diseases
KD Kröncke, K Fehsel, V Kolb-Bachofen |
Clinical & Experimental Immunology | 1998 |
Cloning and characterization of human inducible nitric oxide synthase splice variants: a domain, encoded by exons 8 and 9, is critical for dimerization
NT Eissa, JW Yuan, CM Haggerty, EK Choo, CD Palmer, J Moss |
Proceedings of the National Academy of Sciences | 1998 |
Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide
LP Ho, JA Innes, AP Greening |
Thorax | 1998 |
Interleukin-15 activates proinflammatory and antimicrobial functions in polymorphonuclear cells
T Musso, L Calosso, M Zucca, M Millesimo, M Puliti, S Bulfone-Paus, C Merlino, D Savoia, R Cavallo, AN Ponzi, R Badolato |
Infection and immunity | 1998 |
Role of PKC and Tyrosine Kinase in Ethanol-Mediated Inhibition of LPS-Inducible Nitric Oxide Synthase
SS Greenberg, O Jie, X Zhao, JF Wang |
Alcohol | 1998 |
Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note
SD Smith, MA Wheeler, RM Weiss |
Kidney International | 1998 |
Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide
JB Sampson, Y Ye, H Rosen, JS Beckman |
Archives of Biochemistry and Biophysics | 1998 |
Assessment of the quality of dialysate
LK Lee, TW Meyer, AS Pollock, DH Lovett |
Nephrology Dialysis Transplantation | 1998 |
Stimulus-dependent transduction mechanisms for nitric oxide release in human polymorphonuclear neutrophil leukocytes
G Lärfars, H Gyllenhammar |
Journal of Laboratory and Clinical Medicine | 1998 |
Peroxynitrite production by human neutrophils, monocytes and lymphocytes challenged with lipopolysaccharide
C Gagnon, FA Leblond, JG Filep |
FEBS Letters | 1998 |
Contribution of NO synthases to neutrophil infiltration in the gastric mucosal lesions in rats with water immersion restraint stress
K Nishida, Y Ohta, I Ishiguro |
FEBS Letters | 1998 |
Assessment of the quality of dialysate
LK Lee, TW Meyer, AS Pollock, DH Lovett |
Nephrology Dialysis Transplantation | 1998 |
NITRIC OXIDE IN THE FAILING MYOCARDIUM
DB Sawyer, WS Colucci |
Cardiology Clinics | 1998 |
Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing
MB Hampton, AJ Kettle, CC Winterbourn |
Blood | 1998 |
Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity
FC Fang |
Journal of Clinical Investigation | 1997 |
Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine
SD Smith, MA Wheeler, HE Foster, RM Weiss |
The Journal of Urology | 1997 |
Biosynthesis and action of nitric oxide in mammalian cells
B Mayer, B Hemmens |
Trends in Biochemical Sciences | 1997 |
Activated human neutrophils rapidly break down nitric oxide
AG McBride, GC Brown |
FEBS Letters | 1997 |
Nitric oxide in renal health and disease
BC Kone |
American Journal of Kidney Diseases | 1997 |
Nitric Oxide and the Kidney
MS Goligorsky, SS Gross |
1997 | |
Endogenously Produced Nitric Oxide Increases Tumor Necrosis Factor-α Production in Transfected Human U937 Cells
L Yan, S Wang, SP Rafferty, RA Wesley, RL Danner |
Blood | 1997 |
Nitric Oxide
RA Schroeder, PC Kuo |
Anesthesia & Analgesia | 1995 |
Antioxidants and Cardiovascular Disease
KR Bruckdorfer |
1995 |