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Citations to this article

Bacterial infection induces nitric oxide synthase in human neutrophils.
M A Wheeler, … , R M Weiss, W C Sessa
M A Wheeler, … , R M Weiss, W C Sessa
Published January 1, 1997
Citation Information: J Clin Invest. 1997;99(1):110-116. https://doi.org/10.1172/JCI119121.
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Research Article

Bacterial infection induces nitric oxide synthase in human neutrophils.

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Abstract

The identification of human inflammatory cells that express inducible nitric oxide synthase and the clarification of the role of inducible nitric oxide synthase in human infectious or inflammatory processes have been elusive. In neutrophil-enriched fractions from urine, we demonstrate a 43-fold increase in nitric oxide synthase activity in patients with urinary tract infections compared with that in neutrophil-enriched fractions from noninfected controls. Partially purified inducible nitric oxide synthase is primarily membrane associated, calcium independent, and inhibited by arginine analogues with a rank order consistent with that of purified human inducible nitric oxide synthase. Molecular, biochemical, and immunocytochemical evidence unequivocally identifies inducible nitric oxide synthase as the major nitric oxide synthase isoform found in neutrophils isolated from urine during urinary tract infections. Elevated inducible nitric oxide synthase activity and elevated nitric oxide synthase protein measured in patients with urinary tract infections and treated with antibiotics does not decrease until 6-10 d of antibiotic treatment. The extended elevation of neutrophil inducible nitric oxide synthase during urinary tract infections may have both antimicrobial and proinflammatory functions.

Authors

M A Wheeler, S D Smith, G García-Cardeña, C F Nathan, R M Weiss, W C Sessa

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Expression of Nitric Oxide Synthase in Bladder Smooth Muscle Cells: Regulation by Cytokines and L-Arginine
RK Johansson, M Poljakovic, KE Andersson, K Persson
The Journal of Urology 2002
Analysis of the mechanisms of human cytotoxic T lymphocyte response inhibition by NO
S Blesson, J Thiery, C Gaudin, R Stancou, JP Kolb, JL Moreau, J Theze, F Mami-Chouaib, S Chouaib
International Immunology 2002
Production of nitric oxide by mussel (Mytilus galloprovincialis) hemocytes and effect of exogenous nitric oxide on phagocytic functions
C Tafalla, B Novoa, A Figueras
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2002
The role of nitric oxide in lung innate immunity: modulation by surfactant protein-A
Philip O'Reilly, Judy M Hickman-Davis, Philip McArdle, K Randall Young, Sadis Matalon
Molecular and Cellular Biochemistry 2002
Nitric oxide in patients with transitional bladder cancer: Nitric Oxide in Bladder Cancer
AM Eiján, I Piccardo, MD Riveros, EO Sandes, H Porcella, MA Jasnis, ES de Lustig, H Malagrino, L Pasik, AR Casabé
Journal of Surgical Oncology 2002
Neutrophil defense in patients undergoing bone marrow transplantation: bactericidal/permeability-increasing protein (BPI) and defensins in graft-derived neutrophils1:
O Levy, RB Sisson, HE Fryer, D Goldmann, E Valore, T Ganz, ML White, SF Carroll, L Lehmann, EC Guinan
Transplantation 2002
Oxygen Radicals and Nitric Oxide Levels in Chondral or Meniscal Lesions or Both:
U Haklar, M Yksel, A Velioglu, M Turkmen, G Haklar, AS Yalin
Clinical Orthopaedics and Related Research® 2002
Oxygen/Nitrogen Radicals: Cell Injury and Disease
V Vallyathan, X Shi, V Castranova
2002
Handbook of Antioxidants
K Meissner, W Siems, O Sommerburg, M Leichsenring
Handbook of Antioxidants 2001
Acquired Disorders of Phagocyte Function Complicating Medical and Surgical Illnesses
G Engelich, DG Wright, KL Hartshorn
Clinical Infectious Diseases 2001
Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney
M Poljakovic, ML Svensson, C Svanborg, K Johansson, B Larsson, K Persson
Kidney International 2001
Nitric Oxide Synthase Activity in Neutrophils From Patients With Localized Aggressive Periodontitis
K Shibata, ML Warbington, BJ Gordon, H Kurihara, TE van Dyke
Journal of Periodontology 2001
Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent
WY Tse, J Williams, A Pall, M Wilkes, CO Savage, D Adu
Kidney International 2001
Cyclooxygenase-2 protein and prostaglandin E2 production are up-regulated in a rat bladder inflammation model
MA Wheeler, JH Yoon, LE Olsson, RM Weiss
European Journal of Pharmacology 2001
Effect of adhesion on inducible nitric oxide synthase (iNOS) production in purified human neutrophils
JL Webb, JM Polak, TJ Evans
Clinical & Experimental Immunology 2001
Dexamethasone impairs pulmonary defence against Pseudomonas aeruginosa through suppressing iNOS gene expression and peroxynitrite production in mice
S Satoh, K Oishi, A Iwagaki, M Senba, T Akaike, M Akiyama, N Mukaida, KM Atsushima, T Nagatake
Clinical & Experimental Immunology 2001
Effects of the synthetic selectin inhibitor TBC1269 on tissue damage during acute Mannheimia haemolytica-induced pneumonia in neonatal calves
ZA Radi, JM Caverly, RA Dixon, KA Brogden, MR Ackermann
American Journal of Veterinary Research 2001
Cytotoxic effects of peroxynitrite, polymorphonuclear neutrophils, free-radical scavengers, inhibitors of myeloperoxidase, and inhibitors of nitric oxide synthase on bovine mammary secretory epithelial cells
TK Ledbetter, MJ Paape, LW Douglass
American Journal of Veterinary Research 2001
INDUCIBLE NITRIC OXIDE SYNTHASE IN THE BLADDER OF SPINAL CORD INJURED PATIENTS WITH A CHRONIC INDWELLING URINARY CATHETER
BM Wall, RR Dmochowski, M Malecha, T Mangold, MA Cooke
The Journal of Urology 2001
Anti-inflammatory effects of macrolide antibiotics
O Čulić, V Eraković, MJ Parnham
European Journal of Pharmacology 2001
The physiological role and pharmacological potential of nitric oxide in neutrophil activation
R Armstrong
International Immunopharmacology 2001
Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages
T Kuncewicz, P Balakrishnan, MB Snuggs, BC Kone
American journal of physiology. Renal physiology 2001
Bactericidal Activity of Human Eosinophilic Granulocytes against Escherichia coli
AD O'Brien, T Persson, P Andersson, M Bodelsson, M Laurell, J Malm, A Egesten
Infection and immunity 2001
Nitric Oxide Measurements during Endotoxemia
V Brovkovych, LW Dobrucki, S Brovkovych, I Dobrucki, L Kalinowski, F Kiechle, T Malinski
Clinical chemistry 2001
Neutrophils: Molecules, Functions and Pathophysiological Aspects
V Witko-Sarsat, P Rieu, B Descamps-Latscha, P Lesavre, L Halbwachs-Mecarelli
Laboratory Investigation 2000
Temporal changes of cytokines and nitric oxide products in urine from renal transplant patients
SD Smith, MA Wheeler, MI Lorber, RM Weiss
Kidney International 2000
Interaction between lung surfactant and nitric oxide production by alveolar macrophages stimulated by group B streptococci
RK Bouhafs, C Jarstrand
Pediatric Pulmonology 2000
New directions in allergic diseases: Mechanism-based anti-inflammatory therapies
PJ Barnes
Journal of Allergy and Clinical Immunology 2000
Compartmentalised inducible nitric-oxide synthase activity in septic shock
D Annane, S Sanquer, V Sébille, A Faye, D Djuranovic, JC Raphaël, P Gajdos, E Bellissant
The Lancet 2000
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
C Nathan, MU Shiloh
Proceedings of the National Academy of Sciences 2000
A neutrophil-derived anti-infective molecule: bactericidal/permeability-increasing protein
O Levy
Antimicrobial agents and chemotherapy 2000
Nitrite generation and antioxidant effects during neutrophil apoptosis
NL Misso, CD Peacock, DN Watkins, PJ Thompson
Free radical biology & medicine 2000
Nitric Oxide Regulates the Aggregation of Stimulated Human Neutrophils
T Forslund, HM Nilsson, T Sundqvist
Biochemical and Biophysical Research Communications 2000
Modulation of Polymorphonuclear Leukocytes Function by Nitric Oxide
S Sethi, M Dikshit
Thrombosis Research 2000
Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine
UH Mellqvist, M Hansson, M Brune, C Dahlgren, S Hermodsson, K Hellstrand
Blood 2000
New treatments for asthma
PJ Barnes
European Journal of Internal Medicine 2000
Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents
O Levy
Blood 2000
Enhancement of Neonatal Innate Defense: Effects of Adding an N-Terminal Recombinant Fragment of Bactericidal/Permeability-Increasing Protein on Growth and Tumor Necrosis Factor-Inducing Activity of Gram-Negative Bacteria Tested in Neonatal Cord Blood Ex Vivo
RN Moore, O Levy, RB Sisson, J Kenyon, E Eichenwald, AB Macone, D Goldmann
Infection and immunity 2000
The role of 6R-tetrahydrobiopterin in the nervous system
K Koshimura, Y Murakami, J Tanaka, Y Kato
Progress in Neurobiology 2000
Activation of Nuclear Factor κB and Induction of Inducible Nitric Oxide Synthase by Ureaplasma urealyticum in Macrophages
EI Tuomanen, YH Li, ZQ Yan, JS Jensen, K Tullus, A Brauner
Infection and immunity 2000
l-Arginine supplementation increases mesangial cell injury and subsequent tissue fibrosis in experimental glomerulonephritis
H Peters, WA Border, NA Noble
Kidney International 1999
MAST CELLS MEDIATE THE SEVERITY OF EXPERIMENTAL CYSTITIS IN MICE
DE Bjorling, TJ Jerde, MJ Zine, BW Busser, MR Saban, R Saban
The Journal of Urology 1999
Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase
MU Shiloh, JD MacMicking, S Nicholson, JE Brause, S Potter, M Marino, F Fang, M Dinauer, C Nathan
Immunity 1999
DIRECT DETECTION OF NITRIC OXIDE IN RAT URINARY BLADDER DURING ISCHEMIA-REPERFUSION
M Saito, I Miyagawa
The Journal of Urology 1999
The nitric oxide pathway in pig isolated calyceal smooth muscle
CE Iselin, L Ny, D Mastrangelo, E Felley-Bosco, B Larsson, P Alm, KE Andersson
Neurourology and Urodynamics 1999
A RANDOMIZED DOUBLE-BLIND TRIAL OF ORAL L-ARGININE FOR TREATMENT OF INTERSTITIAL CYSTITIS
GE Korting, SD Smith, MA Wheeler, RM Weiss, HE Foster
The Journal of Urology 1999
INDUCIBLE NITRIC OXIDE SYNTHASE WITH TRANSITIONAL CELL CARCINOMA OF THE BLADDER
HS Swana, SD Smith, PL Perrotta, N Saito, MA Wheeler, RM Weiss
The Journal of Urology 1999
Role of nitric oxide on the replication of viral haemorrhagic septicemia virus (VHSV), a fish rhabdovirus
C Tafalla, A Figueras, B Novoa
Veterinary Immunology and Immunopathology 1999
Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway
SR Thomas, R Stocker
Redox Report 1999
Localized increase in nitric oxide production and the expression of nitric oxide synthase isoforms in rat uterus with experimental intrauterine infection
L Fang, B J Nowicki, Y L Dong, C Yallampalli
American Journal of Obstetrics and Gynecology 1999
Morphological and Biochemical Investigation of Nitric Oxide Synthase and Related Enzymes in the Rat and Pig Urothelium
K Persson, M Poljakovic, K Johansson, B Larsson
Journal of Histochemistry & Cytochemistry 1999
Advances in Bladder Research
LS Baskin, SW Hayward
1999
Gamma Interferon Treatment of Patients with Chronic Granulomatous Disease Is Associated with Augmented Production of Nitric Oxide by Polymorphonuclear Neutrophils
A Åhlin, G Lärfars, G Elinder, J Palmblad, H Gyllenhammar
Clinical and diagnostic laboratory immunology 1999
Activation of Nitric Oxide Release and Oxidative Metabolism by Leukotrienes B4, C4, and D4 in Human Polymorphonuclear Leukocytes
G Lärfars, F Lantoine, MA Devynck, J Palmblad, H Gyllenhammar
Blood 1999
Expression of Human Inducible Nitric Oxide Synthase Gene in T-Cell Lines Infected With Human T-Cell Leukemia Virus Type-I and Primary Adult T-Cell Leukemia Cells
N Mori, Y Nunokawa, Y Yamada, S Ikeda, M Tomonaga, N Yamamoto
Blood 1999
Assessment of the quality of dialysate
LK Lee, TW Meyer, AS Pollock, DH Lovett
Journal of Clinical Investigation 1998
Resistance of filarial nematode parasites to oxidative stress
ME Selkirk, VP Smith, GR Thomas, K Gounaris
International Journal for Parasitology 1998
Pathophysiology of nitric oxide and related species: free radical reactions and modification of biomolecules
JP Eiserich, RP Patel, VB O’Donnell
Molecular Aspects of Medicine 1998
Inducible nitric oxide synthase in human diseases
KD Kröncke, K Fehsel, V Kolb-Bachofen
Clinical & Experimental Immunology 1998
Cloning and characterization of human inducible nitric oxide synthase splice variants: a domain, encoded by exons 8 and 9, is critical for dimerization
NT Eissa, JW Yuan, CM Haggerty, EK Choo, CD Palmer, J Moss
Proceedings of the National Academy of Sciences 1998
Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide
LP Ho, JA Innes, AP Greening
Thorax 1998
Interleukin-15 activates proinflammatory and antimicrobial functions in polymorphonuclear cells
T Musso, L Calosso, M Zucca, M Millesimo, M Puliti, S Bulfone-Paus, C Merlino, D Savoia, R Cavallo, AN Ponzi, R Badolato
Infection and immunity 1998
Role of PKC and Tyrosine Kinase in Ethanol-Mediated Inhibition of LPS-Inducible Nitric Oxide Synthase
SS Greenberg, O Jie, X Zhao, JF Wang
Alcohol 1998
Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note
SD Smith, MA Wheeler, RM Weiss
Kidney International 1998
Myeloperoxidase and horseradish peroxidase catalyze tyrosine nitration in proteins from nitrite and hydrogen peroxide
JB Sampson, Y Ye, H Rosen, JS Beckman
Archives of Biochemistry and Biophysics 1998
Assessment of the quality of dialysate
LK Lee, TW Meyer, AS Pollock, DH Lovett
Nephrology Dialysis Transplantation 1998
Stimulus-dependent transduction mechanisms for nitric oxide release in human polymorphonuclear neutrophil leukocytes
G Lärfars, H Gyllenhammar
Journal of Laboratory and Clinical Medicine 1998
Peroxynitrite production by human neutrophils, monocytes and lymphocytes challenged with lipopolysaccharide
C Gagnon, FA Leblond, JG Filep
FEBS Letters 1998
Contribution of NO synthases to neutrophil infiltration in the gastric mucosal lesions in rats with water immersion restraint stress
K Nishida, Y Ohta, I Ishiguro
FEBS Letters 1998
Assessment of the quality of dialysate
LK Lee, TW Meyer, AS Pollock, DH Lovett
Nephrology Dialysis Transplantation 1998
NITRIC OXIDE IN THE FAILING MYOCARDIUM
DB Sawyer, WS Colucci
Cardiology Clinics 1998
Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing
MB Hampton, AJ Kettle, CC Winterbourn
Blood 1998
Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity
FC Fang
Journal of Clinical Investigation 1997
Improvement in Interstitial Cystitis Symptom Scores During Treatment With Oral L-Arginine
SD Smith, MA Wheeler, HE Foster, RM Weiss
The Journal of Urology 1997
Biosynthesis and action of nitric oxide in mammalian cells
B Mayer, B Hemmens
Trends in Biochemical Sciences 1997
Activated human neutrophils rapidly break down nitric oxide
AG McBride, GC Brown
FEBS Letters 1997
Nitric oxide in renal health and disease
BC Kone
American Journal of Kidney Diseases 1997
Nitric Oxide and the Kidney
MS Goligorsky, SS Gross
1997
Endogenously Produced Nitric Oxide Increases Tumor Necrosis Factor-α Production in Transfected Human U937 Cells
L Yan, S Wang, SP Rafferty, RA Wesley, RL Danner
Blood 1997
Nitric Oxide
RA Schroeder, PC Kuo
Anesthesia & Analgesia 1995
Antioxidants and Cardiovascular Disease
KR Bruckdorfer
1995

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