Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m.
S D Khare, … , H S Luthra, C S David
S D Khare, … , H S Luthra, C S David
Published December 15, 1996
Citation Information: J Clin Invest. 1996;98(12):2746-2755. https://doi.org/10.1172/JCI119100.
View: Text | PDF
Research Article

HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin (beta2m) double transgenic mice with disrupted mouse beta2m.

  • Text
  • PDF
Abstract

MHC class I allele, HLA-B27, is strongly associated with a group of human diseases called spondyloarthropathies. Some of these diseases have an onset after an enteric or genitourinary infection. In the present study, we describe spontaneous disease in HLA-B27 transgenic mice where endogenous beta2-microglobulin (beta2m) gene was replaced with transgenic human beta2m gene. These mice showed cell surface expression of HLA-B27 similar to that of human peripheral blood mononuclear cells. In addition, free heavy chains (HCs) of HLA-B27 were also expressed on thymic epithelium and on a subpopulation of B27-expressing PBLs. These mice developed spontaneous arthritis and nail changes in the rear paws. Arthritis occurred primarily in male animals and only when mice were transferred from the pathogen-free barrier facility to the conventional area. Transgenic mice expressing HLA-B27 with mouse beta2m have undetectable levels of free HCs on the cell surface and do not develop arthritis. In vivo treatment with anti-HC-specific antibody delayed the onset of disease. Our data demonstrate specific involvement of HLA-B27 'free' HCs in the disease process.

Authors

S D Khare, J Hansen, H S Luthra, C S David

×

Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1982 Total
Citations: 2 2 3 5 2 1 1 2 2 6 2 5 5 3 2 3 7 4 3 3 9 8 7 4 10 1 102
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (102)

Title and authors Publication Year
Diversity in the HLA-I Recognition of HLA-F Monoclonal Antibodies: HLA-F or HLA-Ib Monospecific, HLA-E or HLA-G Bispecific Antibodies with or without HLA-Ia Reactivity
Ravindranath MH, Ravindranath NM, Amato-Menker CJ, El Hilali F, Filippone EJ
Antibodies 2024
Conformational Alterations of the Cell Surface of Monomeric and Dimeric β2m-Free HLA-I (Proto-HLA) May Enable Novel Immune Functions in Health and Disease.
Ravindranath MH, Ravindranath NM, Amato-Menker CJ, Hilali FE, Filippone EJ
Current issues in molecular biology 2024
Antibodies for β2-Microglobulin and the Heavy Chains of HLA-E, HLA-F, and HLA-G Reflect the HLA-Variants on Activated Immune Cells and Phases of Disease Progression in Rheumatoid Arthritis Patients under Treatment.
Ravindranath MH, Ravindranath NM, Amato-Menker CJ, El Hilali F, Selvan SR, Filippone EJ, Morales-Buenrostro LE
2023
Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?
Ravindranath MH, Ravindranath NM, Selvan SR, Hilali FE, Amato-Menker CJ, Filippone EJ
Biomolecules 2023
Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines.
Ravindranath MH, Ravindranath NM, Selvan SR, Filippone EJ, Amato-Menker CJ, El Hilali F
Human vaccines 2022
Role of HLA-I Structural Variants and the Polyreactive Antibodies They Generate in Immune Homeostasis.
Ravindranath MH, El Hilali F, Amato-Menker CJ, El Hilali H, Selvan SR, Filippone EJ
2022
Spondyloarthritides: Theories and beyond.
Kocatürk B, Balık Z, Pişiren G, Kalyoncu U, Özmen F, Özen S
Frontiers in Pediatrics 2022
The Role of the IL-23/IL-17 Axis in Disease Initiation in Spondyloarthritis: Lessons Learned From Animal Models
M Mandour, S Chen, MG van de Sande
Frontiers in immunology 2021
Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells
Y Gao, X Yao, Y Zhai, L Li, H Li, X Sun, P Yu, T Xue, Y Li, Y Hu
Cell Death and Disease 2021
Importance of HLA in Determining Individual Differences in the Onset of Adverse Drug Reactions
S Aoki
YAKUGAKU ZASSHI 2021
A Potential New Mouse Model of Axial Spondyloarthritis Involving the Complement System
V Holers, F Rosa, N Banda
Immune Network 2021
Therapeutic Potential of HLA-I Polyreactive mAbs Mimicking the HLA-I Polyreactivity and Immunoregulatory Functions of IVIg
MH Ravindranath, FE Hilali, EJ Filippone
Human vaccines 2021
Roles of Porphyromonas gingivalis and its virulence factors in periodontitis.
Xu W, Zhou W, Wang H, Liang S
Advances in protein chemistry and structural biology 2020
HLA transgenic mice: application in reproducing idiosyncratic drug toxicity
T Susukida, S Aoki, T Shirayanagi, Y Yamada, S Kuwahara, K Ito
Drug Metabolism Reviews 2020
Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain
H Yorifuji, N Arase, M Kohyama, T Hirano, T Suenaga, A Kumanogoh, H Arase
Biochemical and Biophysical Research Communications 2019
Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function
J Geng, JD Altman, S Krishnakumar, M Raghavan
eLife 2018
Autoimmune aspects of psoriasis: Heritability and autoantigens
JC Prinz
Autoimmunity Reviews 2017
Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice
T Susukida, S Aoki, K Kogo, S Fujimori, B Song, C Liu, S Sekine, K Ito
Archives of Toxicology 2017
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review
A Sukhov, IE Adamopoulos, E Maverakis
Clinical Reviews in Allergy & Immunology 2016
Intraocular Inflammation
M Zierhut, C Pavesio, S Ohno, F Orefice, NA Rao
2016
The synovio-entheseal complex in enthesoarthritis
AD Cata, M Inglese, R Rubino, F Molinaro, G Mazzoccoli
Clinical and Experimental Medicine 2015
Review: Animal Models as a Tool to Dissect Pivotal Pathways Driving Spondyloarthritis: ANIMAL MODELS OF SPONDYLOARTHRITIS
E Vieira-Sousa, LM van Duivenvoorde, JE Fonseca, RJ Lories, DL Baeten
Arthritis & Rheumatology 2015
HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats
OM Belaunzaran, S Kleber, S Schauer, M Hausmann, F Nicholls, MV Broek, S Payeli, A Ciurea, S Milling, F Stenner, J Shaw, S Kollnberger, P Bowness, U Petrausch, C Renner, AN Antoniou
PloS one 2015
HLA-B27 and psoriatic disease: a modern view of an old relationship: Fig. 1
R Queiro, I Morante, I Cabezas, B Acasuso
Rheumatology 2015
Ocular Inflammation in HLA-B27 Transgenic Mice Reveals a Potential Role for MHC Class I in Corneal Immune Privilege
Aifeng Lin, Xiaoxin Guo, Robert D. Inman, Jeremy M. Sivak
Molecular vision 2015
HLA-B27
P Bowness
Annual Review of Immunology 2015
The link between HLA-B27 and SpA--new ideas on an old problem
K McHugh, P Bowness
Rheumatology 2012
The Laboratory Mouse
A Braun, H Ernst, D Schaudien, HG Hoymann, S Rittinghausen
The Laboratory Mouse 2012
Chella David: A lifetime contribution in translational immunology
ME Gershwin, Y Shoenfeld
Journal of Autoimmunity 2011
A brief autobiography
C David
Journal of Autoimmunity 2011
β2-Microglobulin is Required for the Full Expression of Xenobiotic-Induced Systemic Autoimmunity
KM Pollard, P Hultman, CB Toomey, DM Cauvi, DH Kono, DH Konoc
Journal of Immunotoxicology 2011
Redundancy of the influenza A virus-specific cytotoxic T lymphocyte response in HLA-B*2705 transgenic mice limits the impact of a mutation in the immunodominant NP383–391 epitope on influenza pathogenesis
R Bodewes, MM Geelhoed-Mieras, NJ Nieuwkoop, JA Hanson, CS David, RA Fouchier, AD Osterhaus, GF Rimmelzwaan
Virus Research 2011
Ly49-Dependent NK Cell Licensing and Effector Inhibition Involve the Same Interaction Site on MHC Ligands
T Choi, ST Ferris, N Matsumoto, J Poursine-Laurent, WM Yokoyama
Journal of immunology (Baltimore, Md. : 1950) 2011
Endoplasmic reticulum aminopeptidases: biology and pathogenic potential
N Haroon, RD Inman
Nature Reviews Rheumatology 2010
From HLA-B27 to spondyloarthritis: a journey through the ER
RA Colbert, ML DeLay, EI Klenk, G Layh-Schmitt
Immunological Reviews 2010
Mouse model to study human A β2M amyloidosis: generation of a transgenic mouse with excessive expression of human β2-microglobulin
P Zhang, X Fu, J Sawashita, J Yao, B Zhang, J Qian, H Tomozawa, M Mori, Y Ando, H Naiki, K Higuchi
Amyloid 2010
Rook's Textbook of Dermatology: Burns/Rook's Textbook of Dermatology
PS Friedmann, MR Ardern-Jones, CA Holden
Rook's Textbook of Dermatology: Burns/Rook's Textbook of Dermatology 2010
HLA B27 et spondylarthropathies
C Miceli-Richard
Revue du Rhumatisme Monographies 2010
Kelley's Textbook of Rheumatology
J Degroot, AM Zuurmond, PP Tak
Kelley's Textbook of Rheumatology 2009
HLA‑B27 misfolding and spondyloarthropathies
RA Colbert, ML DeLay, G Layh-Schmitt, DP Sowders
Prion 2009
Molecular Mechanisms of Spondyloarthropathies
C López-Larrea, R Díaz-Peña
2009
A review of the pathogenesis of ankylosing spondylitis
E Dakwar, J Reddy, FL Vale, JS Uribe
Neurosurgical FOCUS 2008
Valor diagnóstico del HLA-B27 en las espondiloartropatías
BA Barca, AM Varela
Seminarios de la Fundación Española de Reumatología 2008
Mouse Models of Psoriasis
JE Gudjonsson, A Johnston, M Dyson, H Valdimarsson, JT Elder
Journal of Investigative Dermatology 2007
Genetics of Reactive Arthritis
A Chan, P Wordsworth
Psoriatic and Reactive Arthritis 2007
Salmonella as an Inducer of Autoimmunity
MJ Soloski, ES Metcalf, MS Donnenberg
EcoSal Plus 2007
Humanized mouse models for organ-specific autoimmune diseases
MA Friese, LT Jensen, N Willcox, L Fugger
Current Opinion in Immunology 2006
Animal models of HLA-B27-associated diseases: new outcomes
C Hacquard-Bouder, M Ittah, M Breban
Joint Bone Spine 2006
The Autoimmune Diseases
I Kang, J Craft
The Autoimmune Diseases 2006
Ankylosing Spondylitis: Diagnosis and Management
A Timms, B Wordsworth, M Brown
Ankylosing Spondylitis: Diagnosis and Management 2006
Modèles animaux de spondylarthropathies liés au HLA-B27 : où en est la recherche ?
C Hacquard-Bouder, M Ittah, M Breban
Revue du Rhumatisme 2006
Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles
T Raine, D Brown, P Bowness, JS Gaston, A Moffett, J Trowsdale, RL Allen
Rheumatology (Oxford, England) 2006
The Hereditary Basis of Rheumatic Diseases
R Holmdahl
2006
MHC-I recognition by receptors on myelomonocytic cells: New tricks for old dogs?
T Raine, R Allen
BioEssays 2005
Aetiology and pathogenesis of reactive arthritis: role of non-antigen-presenting effects of HLA-B27
S Vähämiko, MA Penttinen, K Granfors
Arthritis Research & Therapy 2005
Acute Anterior Uveitis and HLA-B27
JH Chang, PJ McCluskey, D Wakefield
Survey of Ophthalmology 2005
The amino acid at position 97 is involved in folding and surface expression of HLA-B27
MA Blanco-Gelaz, B Suárez-Alvarez, S González, A López-Vázquez, J Martínez-Borra, C López-Larrea
International Immunology 2005
HLA-B27 Heavy Chain Homodimers Are Expressed in HLA-B27 Transgenic Rodent Models of Spondyloarthritis and Are Ligands for Paired Ig-Like Receptors
S Kollnberger, LA Bird, M Roddis, C Hacquard-Bouder, H Kubagawa, HC Bodmer, M Breban, AJ McMichael, P Bowness
Journal of immunology (Baltimore, Md. : 1950) 2004
Structure-Modifying Capacity of Anti-Tumour Necrosis Factor-?? Therapy in Ankylosing Spondylitis:
FD Keyser, D Baeten, FV den Bosch, E Kruithof, G Verbruggen, H Mielants, E Veys
Drugs 2004
Infection and Autoimmunity
C Dugué, Y Renaudineau, P Youinou
Infection and Autoimmunity 2004
Animal models of inflammatory spinal and sacroiliac joint diseases
Y Zhang
Rheumatic Disease Clinics of North America 2003
Role of bacteria and HLA-B27 in the pathogenesis of reactive arthritis
D Yu, JG Kuipers
Rheumatic Disease Clinics of North America 2003
Molekularmedizinische Grundlagen von rheumatischen Erkrankungen
D Ganten, K Ruckpaul, S Gay, JR Kalden
2003
Mice lacking endogenous major histocompatibility complex class II develop arthritis resembling psoriatic arthritis at an advanced age
T Bárdos, J Zhang, K Mikecz, CS David, TT Glant
Arthritis & Rheumatism 2002
Cell-surface expression and immune receptor recognition of HLA-B27 homodimers
S Kollnberger, L Bird, MY Sun, C Retiere, VM Braud, A McMichael, P Bowness
Arthritis & Rheumatism 2002
HLA-B27 and pathogenesis of spondyloarthropathies
MJ Turner, RA Colbert
Current Opinion in Rheumatology 2002
Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen
E Frauendorf, JA de Castro, E Marker-Hermann
Tissue Antigens 2002
HLA-B27 and the pathogenesis of spondyloarthritis
M Ramos, JA de Castro
Tissue Antigens 2002
Identification and sequencing of HLA-B*0714 and B*2718 alleles and novel exon 1 sequences of B*0709 and B*2714 alleles in potential bone marrow donors
D Feldman, J Kearns, J Wu, S Bassinger, GD Montoya, M McKeen, S Birkos, TM Williams, M Kamoun
Tissue Antigens 2002
Animal models of ankylosing spondylitis
Y Zhang, S Shi, C Ciurli, AR Poole
Current Rheumatology Reports 2002
HLA-B27: natural function and pathogenic role in spondyloarthritis
A McMichael, P Bowness
Arthritis research 2002
Pharmacogenomic analysis of rhIL-11 treatment in the HLA-B27 rat model of inflammatory bowel disease
RL Peterson, L Wang, L Albert, E Marchese, J Erickson, A Wong, WM Mounts, L Hayes, P Bouchard, J Keith, AJ Dorner
The Pharmacogenomics Journal 2002
Predisposing factors in the Spondyloarthropathies: New insights into the role of HLA-B27
RA Colbert, S Prahalad
Current Rheumatology Reports 2001
Role of β2-Microglobulin in the Immune Response in Renal Osteodystrophy
E Balint
Seminars in Dialysis 2001
Spontaneous Inflammatory Disease in HLA-B27 Transgenic Mice Does Not Require Transporter of Antigenic Peptides
SD Khare, S Lee, MJ Bull, J Hanson, HS Luthra, CS David
Clinical Immunology 2001
Molecular diversity of the HLA-B27 gene and its association with disease
NK Mehra, U Kanga
Modern Rheumatology 2001
Interactions of HLA-B27 with the peptide loading complex as revealed by heavy chain mutations
MR Harris, L Lybarger, NB Myers, C Hilbert, JC Solheim, TH Hansen, YY Yu
International Immunology 2001
Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2
JA Urvater, H Hickman, JL Dzuris, K Prilliman, TM Allen, KJ Schwartz, D Lorentzen, C Shufflebotham, EJ Collins, DL Neiffer, B Raphael, W Hildebrand, A Sette, DI Watkins
Journal of immunology (Baltimore, Md. : 1950) 2001
Cutting Edge: Leukocyte Receptor Complex-Encoded Immunomodulatory Receptors Show Differing Specificity for Alternative HLA-B27 Structures
RL Allen, T Raine, A Haude, J Trowsdale, MJ Wilson
Journal of immunology (Baltimore, Md. : 1950) 2001
HLA-B27 Expression Does Not Modulate Intracellular Chlamydia trachomatis Infection of Cell Lines
BB Finlay, JL Young, L Smith, MK Matyszak, JS Gaston
Infection and immunity 2001
Expression of Intrinsic Factor in Rat and Murine Gastric Mucosal Cell Lineages Is Modified by Inflammation
J Shao, RB Sartor, E Dial, LM Lichtenberger, W Schepp, DH Alpers
The American Journal of Pathology 2000
HLA-B27 misfolding: a solution to the spondyloarthropathy conundrum?
RA Colbert
Molecular Medicine Today 2000
Expression of intrinsic factor in rat and murine gastric mucosal cell lineages is modified by inflammation
J Shao, RB Sartor, E Dial, LM Lichtenberger, W Schepp, DH Alpers
The American Journal of Pathology 2000
Function-related regulation of the stability of MHC proteins
A Simon, Z Dosztányi, E Rajnavölgyi, I Simon
Biophysical Journal 2000
HLA-B27 transgenic mice are susceptible to collagen-induced arthritis: type II collagen as a potential target in human disease
S Lee, SD Khare, MM Griffiths, HS Luthra, CS David
Human Immunology 2000
Function-Related Regulation of the Stability of MHC Proteins
Á Simon, Z Dosztányi, É Rajnavölgyi, I Simon
Biophysical Journal 2000
Germ-free mice do not develop ankylosing enthesopathy, a spontaneous joint disease
Z Řeháková, J Čapková, R Štěpánková, J Šinkora, A Loužecká, P Ivanyi, S Weinreich
Human Immunology 2000
A molecular insight on the association of HLA-B27 with spondyloarthropathies
M Martí, I Álvarez, JA de Castro
Current Rheumatology Reports 1999
Immunogenetics, HLA-B27 and spondyloarthropathies
S González, J Martínez-Borra, C López-Larrea
Current Opinion in Rheumatology 1999
Peptide-conformed β2m-free class I heavy chains are intermediates in generation of soluble HLA by the membrane-bound metalloproteinase
S Demaria, LD DeVito-Haynes, RD Salter, WJ Burlingham, Y Bushkin
Human Immunology 1999
Peptide binding α1α2 domain of HLA-B27 contributes to the disease pathogenesis in transgenic mice
SD Khare, S Lee, MJ Bull, J Hanson, HS Luthra, GJ Hammerling, CS David
Human Immunology 1999
HLA transgenic mice as humanized mouse models of disease and immunity
V Taneja, CS David
Journal of Clinical Investigation 1998
The pathogenetic role of HLA-B27 in chronic arthritis
JA de Castro
Current Opinion in Immunology 1998
Ligand-free MHC class I conformation
T Hansen
Nature Structural Biology 1998
HLA transgenic mice as humanized mouse models of disease and immunity
V Taneja, CS David
Immunological Reviews 1998
The metalloproteinase-mediated pathway is essential for generation of soluble HLA class I proteins by activated cells in vitro:
LD DeVito-Haynes, S Demaria, Y Bushkin, WJ Burlingham
Human Immunology 1998
4 Animal models and in vitro models for the study of aetiopathogenesis of spondyloarthropathies
M Breban
Baillière's Clinical Rheumatology 1998
ANIMAL MODELS OF HUMAN LEUKOCYTE ANTIGEN B27-LINKED ARTHRITIDES
SD Khare, HS Luthra, CS David
Rheumatic Disease Clinics of North America 1998
Arthritis in HLA-B27 Transgenic Animals
JD Taurog
The American Journal of the Medical Sciences 1998
Arthritis in HLA-B27 Transgenic Animals:
JD Taurog
The American Journal of the Medical Sciences 1998
MICA allele typing of HLA-B27 positive japanese patients with seronegative spondylarthropathies and healthy individuals: Differential linkage disequilibrium with HLA-B27 subtypes
N Tsuchiya, M Shiota, S Moriyama, A Ogawa, M Komatsu-Wakui, H Mitsui, DE Geraghty, K Tokunaga
Arthritis & Rheumatism 1998
Reactive arthritis
CR Hind
Postgraduate medical journal 1982

← Previous 1 2 3 4 5 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts