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D L Kasper, … , H J Jennings, C J Baker
Published November 15, 1996
Citation Information: J Clin Invest. 1996;98(10):2308-2314. https://doi.org/10.1172/JCI119042.
Citation Information: J Clin Invest. 1996;98(10):2308-2314. https://doi.org/10.1172/JCI119042.
Abstract
Group B Streptococcus (GBS) is an important perinatal pathogen. Because transplacentally acquired maternal antibodies to the GBS capsular polysaccharides (CPS) confer protection, prevention of infant disease may be possible after immunization of women. Unfortunately, the purified CPS of GBS are only variably immunogenic in adults; therefore to enhance immunogenicity we have designed and developed a CPS-protein conjugate vaccine. The lability of a conformationally dependent epitope on the III CPS containing a critical sialic acid residue was important to consider in vaccine design. 100 women were randomized to receive GBS type III CPS-tetanus toxoid conjugate (III-TT) vaccine at one of three doses; unconjugated GBS type III CPS; or saline. Serum samples were obtained before immunization and 2, 4, 8, and 26 wk thereafter, and specific antibody to type III CPS was measured. Vaccines were well tolerated. In sera from recipients of the highest dose of III-TT, CPS-specific IgG levels rose from a geometric mean of 0.09 microg/ml before immunization to 4.53 microg/ml 8 wk later, whereas levels in recipients of unconjugated type III CPS rose from 0.21 microg/ml to 1.41 microg/ml. Lower doses resulted in lower antibody levels. A > or = 4-fold rise in antibody concentration was achieved in 90% of recipients of III-TT compared with 50% of those that received III CPS (P = 0.0015). Antibodies evoked by the conjugate vaccine recognized a conformationally dependent epitope of the III-CPS, promoted opsonophagocytosis and killing of GBS, and, after maternal immunization, protected neonatal mice from lethal challenge with type III GBS. We conclude that directed coupling of type III GBS polysaccharide to a carrier protein yielded a conjugate vaccine with preserved expression of a highly labile conformational epitope involving sialic acid and enhanced immunogenicity compared with uncoupled CPS.
Authors
D L Kasper, L C Paoletti, M R Wessels, H K Guttormsen, V J Carey, H J Jennings, C J Baker
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|
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A Vaccine Against Group B Streptococcus: Recent Advances C Carreras-Abad, L Ramkhelawon, PT Heath, KL Doare |
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|
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|
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|
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|
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2005 | |
|
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E Persson, S Berg, B Trollfors, P Larsson, E Ek, E Backhaus, BE Claesson, L Jonsson, G Radberg, T Ripa, S Johansson |
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|
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|
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|
Study of Capsular Polysaccharide from Vibrioparahaemolyticus
YC Hsieh, SM Liang, WL Tsai, YH Chen, TY Liu, CM Liang |
Infection and immunity | 2003 |
|
Type III group B streptococcal polysaccharide induces antibodies that cross-react with Streptococcus pneumoniae type 14
HK Guttormsen, CJ Baker, MH Nahm, LC Paoletti, SM Zughaier, MS Edwards, DL Kasper |
Infection and immunity | 2002 |
|
Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein
D Martin, S Rioux, E Gagnon, M Boyer, J Hamel, N Charland, BR Brodeur |
Infection and immunity | 2002 |
|
Serotyping group B streptococci in a small community hospital: an analysis of distribution and site of isolation
JM Smith, JA Rexroth, DG Chaffin, SH Jackman |
Infectious diseases in obstetrics and gynecology | 2002 |
|
Group B streptococci during pregnancy and infancy
R Berner |
Current Opinion in Infectious Diseases | 2002 |
|
Vaccines to prevent neonatal GBS infection
LC Paoletti, LC Madoff |
Seminars in Neonatology | 2002 |
|
Humoral Immune Response in Mice Over-expressing or Deficient in Growth Hormone
MA Hall, A Bartke, JM Martinko |
Experimental biology and medicine (Maywood, N.J.) | 2002 |
|
Group B Streptococcus: silent but deadly
C Atherton |
2002 | |
|
Potency of clinical group B streptococcal conjugate vaccines
LC Paoletti |
Vaccine | 2001 |
|
Effect of pre-existing immunity for systemic and mucosal immune responses to intranasal immunization with group B Streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate
X Shen, T Lagergård, Y Yang, M Lindblad, M Fredriksson, G Wallerström, J Holmgren |
Vaccine | 2001 |
|
Impairment of Type III Group B Streptococcus-Stimulated Superoxide Production and Opsonophagocytosis by Neutrophils in Diabetes
MA Mazade, MS Edwards |
Molecular Genetics and Metabolism | 2001 |
|
Initial Studies of the Molecular Basis of Peptide Mimicry of Group B Streptococcal Type III Capsular Polysaccharide
SH Pincus, SR Lepage, RF Jung, JG Massey, M Jaseja |
International Reviews of Immunology | 2001 |
|
Anti-idiotypic Vaccination against Group B Streptococci
C Beninati, M Oggioni, G Mancuso, A Midiri, L Polonelli, G Pozzi, G Teti |
International Reviews of Immunology | 2001 |
|
Vaccines in Pregnancy
FM Munoz, JA Englund |
Infectious Disease Clinics of North America | 2001 |
|
Modulation of the complement system in the prevention and treatment of sepsis
E Andrews, PA Feldhoff, HA Lassiter |
Seminars in Pediatric Infectious Diseases | 2001 |
|
Maternal vaccines
WP Glezen |
Primary Care Clinics in Office Practice | 2001 |
|
The Molecular Immunology of Complex Carbohydrates —2
AM Wu |
2001 | |
|
Effects of Alum Adjuvant or a Booster Dose on Immunogenicity during Clinical Trials of Group B Streptococcal Type III Conjugate Vaccines
EI Tuomanen, LC Paoletti, MA Rench, DL Kasper, D Molrine, D Ambrosino, CJ Baker |
Infection and immunity | 2001 |
|
Group B Streptococcus Capsular Polysaccharide-Cholera Toxin B Subunit Conjugate Vaccines Prepared by Different Methods for Intranasal Immunization
EI Tuomanen, X Shen, T Lagergård, Y Yang, M Lindblad, M Fredriksson, J Holmgren |
Infection and immunity | 2001 |
|
Localization of Surface Immunogenic Protein on Group B Streptococcus
EI Tuomanen, S Rioux, D Martin, HW Ackermann, J Dumont, J Hamel, BR Brodeur |
Infection and immunity | 2001 |
|
Serotypes and clinical manifestations of group B streptococcal infections in western Sweden
S Berg, B Trollfors, T Lagergard, G Zackrisson, BA Claesson |
Clinical Microbiology and Infection | 2000 |
|
Preparation and preclinical evaluation of experimental group B streptococcus type III polysaccharide–cholera toxin B subunit conjugate vaccine for intranasal immunization
X Shen, T Lagergård, Y Yang, M Lindblad, M Fredriksson, J Holmgren |
Vaccine | 2000 |
|
A STEP AHEAD
FM Munoz, JA Englund |
Pediatric Clinics of North America | 2000 |
|
An NMR Spectroscopic Identity Test for the Control of the Capsular Polysaccharide from Haemophilus influenzae Type b
X Lemercinier, C Jones |
Biologicals | 2000 |
|
Group B Streptococcal Colonization and Serotype-Specific Immunity in Pregnant Women at Delivery:
JR Campbell, SL Hillier, MA Krohn, P Ferrieri, DF Zaleznik, CJ Baker |
Obstetrics & Gynecology | 2000 |
|
Effect of Molecular Size on the Ability of Zwitterionic Polysaccharides to Stimulate Cellular Immunity
WM Kalka-Moll, AO Tzianabos, Y Wang, VJ Carey, RW Finberg, AB Onderdonk, DL Kasper |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
|
Identification of Group B Streptococcal Sip Protein, Which Elicits Cross-Protective Immunity
EI Tuomanen, BR Brodeur, M Boyer, I Charlebois, J Hamel, F Couture, CR Rioux, D Martin |
Infection and immunity | 2000 |
|
Neonatal group B streptococcal disease in Finland: a ten-year nationwide study
S Kalliola, J Vuopio-Varkila, AK Takala, J Eskola |
The Pediatric Infectious Disease Journal | 1999 |
|
Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines
HK Guttormsen, AH Sharpe, AK Chandraker, AK Brigtsen, MH Sayegh, DL Kasper |
Infection and immunity | 1999 |
|
Measurement of human antibodies to type III group B Streptococcus
DL Kasper, MR Wessels, HK Guttormsen, LC Paoletti, MS Edwards, CJ Baker |
Infection and immunity | 1999 |
|
BACTERIAL MENINGITIS
DH Spach, LA Jackson |
Neurologic Clinics | 1999 |
|
Group B streptococcus
A Schuchat |
The Lancet | 1999 |
|
Preparation of Novel Conjugates Involving Immunomodulating Peptidoglycan Monomer
J Tomašić, B Špoljar, Ð Ljevaković, CP Glaudemans |
Preparative Biochemistry & Biotechnology | 1999 |
|
Ozonolytic depolymerization of polysaccharides in aqueous solution
Y Wang, RI Hollingsworth, DL Kasper |
Carbohydrate Research | 1999 |
|
Group B streptococcal infections
M Fernandez, CJ Baker |
Seminars in Pediatric Infectious Diseases | 1999 |
|
Measurement of Human Antibodies to Type III Group B Streptococcus
DL Kasper, MR Wessels, HK Guttormsen, LC Paoletti, MS Edwards, CJ Baker |
Infection and immunity | 1999 |
|
Alpha C Protein as a Carrier for Type III Capsular Polysaccharide and as a Protective Protein in Group B Streptococcal Vaccines
VA Fischetti, C Gravekamp, DL Kasper, LC Paoletti, LC Madoff |
Infection and immunity | 1999 |
|
Lmb, a Protein with Similarities to the LraI Adhesin Family, Mediates Attachment of Streptococcus agalactiae to Human Laminin
EI Tuomanen, B Spellerberg, E Rozdzinski, S Martin, J Weber-Heynemann, N Schnitzler, R Lütticken, A Podbielski |
Infection and immunity | 1999 |
|
The preparation of neoglycoconjugates containing inter-saccharide phosphodiester linkages as potential anti-Leishmania vaccines
F H Routier, A V Nikolaev, M A Ferguson |
Glycoconjugate Journal | 1999 |
|
Capsular polysaccharide-protein conjugate vaccines and intravenous immunoglobulins
RK Sood, A Fattom |
Expert Opinion on Investigational Drugs | 1998 |
|
Cervical Secretions in Pregnant Women Colonized Rectally with Group B Streptococci have High Levels of Antibodies to Serotype III Polysaccharide Capsular Antigen and Protein R
Hordnes, Tynning, Kvam, Bevanger, Brown, Jonsson, Haneberg |
Scandinavian Journal of Immunology | 1998 |
|
Structural properties of group B streptococcal type III polysaccharide conjugate vaccines that influence immunogenicity and efficacy
MR Wessels, LC Paoletti, HK Guttormsen, F Michon, AJ D'Ambra, DL Kasper |
Infection and immunity | 1998 |
|
Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model
HK Guttormsen, LM Wetzler, RW Finberg, DL Kasper |
Infection and immunity | 1998 |
|
Epidemiology of group B streptococcal disease in the United States: shifting paradigms
A Schuchat |
Clinical microbiology reviews | 1998 |
|
Infectious diseases in early life in industrialized countries
PF Wright, PF Wright |
Vaccine | 1998 |
|
Neonatal mouse immunity against group B streptococcal infection by maternal vaccination with recombinant anti-idiotypes
W Magliani, L Polonelli, S Conti, A Salati, PF Rocca, V Cusumano, G Mancuso, G Teti |
Nature Medicine | 1998 |
|
Maternal immunization for the prevention of bacterial infection in young infants
K Mulholland |
Vaccine | 1998 |
|
Prophylaxis for neonatal group B streptococcus infections
JD Siegel |
Seminars in Perinatology | 1998 |
|
The optimization of helper T lymphocyte (HTL) function in vaccine development
SA Kalams, BD Walker |
Immunologic Research | 1998 |
|
The optimization of helper T lymphocyte (HTL) function in vaccine development
SA Kalams, BD Walker |
Immunologic Research | 1998 |
|
Properties of Human Anti-Group B Streptococcal Type III Capsular IgG Antibody
RG Feldman, MA Breukels, S David, GT Rijkers |
Clinical Immunology and Immunopathology | 1998 |
|
Murine Immune Responses to Neisseria meningitidis Group C Capsular Polysaccharide and a Thymus-Dependent Toxoid Conjugate Vaccine
TR Kozel, LJ Rubinstein, PA García-Ojeda, F Michon, HJ Jennings, KE Stein |
Infection and immunity | 1998 |
|
Structural Properties of Group B Streptococcal Type III Polysaccharide Conjugate Vaccines That Influence Immunogenicity and Efficacy
MR Wessels, LC Paoletti, HK Guttormsen, F Michon, AJ DAmbra, DL Kasper |
Infection and immunity | 1998 |
|
Estimation of Group B Streptococcus Type III Polysaccharide-Specific Antibody Concentrations in Human Sera Is Antigen Dependent
VA Fischetti, R Bhushan, BF Anthony, CE Frasch |
Infection and immunity | 1998 |
|
Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus
J Li, DL Kasper, FM Ausubel, B Rosner, JL Michel |
Proceedings of the National Academy of Sciences | 1997 |
|
Group B Streptococcus And Pregnancy: Update and Recommendations
A Mitchell, N Steffenson, H Hogan, S Brooks |
MCN, The American Journal of Maternal/Child Nursing | 1997 |
|
Bacterial Meningitis in the United States in 1995
A Schuchat, K Robinson, JD Wenger, LH Harrison, M Farley, AL Reingold, L Lefkowitz, BA Perkins |
New England Journal of Medicine | 1997 |
|
Inactivation of the C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenuation of virulence and immunity in group B Streptococcus
J Li, DL Kasper, FM Ausubel, B Rosner, JL Michel |
Proceedings of the National Academy of Sciences | 1997 |
|
Preventing neonatal Group B streptococcal disease: The role of the clinical microbiology laboratory
SL Hillier, A Schuchat |
Clinical Microbiology Newsletter | 1997 |
|
Prevention of Group B Streptococcus Infection in Neonates
BA Logsdon, DT Casto |
The Annals of pharmacotherapy | 1997 |
|
Group B Streptococcal Infections
CJ Baker, MS Edwards |
Annals of the New York Academy of Sciences | 1988 |
|
Infectious Diseases
AM Ramsay, RT Emond |
Infectious Diseases | 1967 |
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