Abnormal vascular smooth muscle cell (SMC) proliferation and migration contribute to the development of restenosis after percutaneous transluminal coronary angioplasty and accelerated arteriopathy after cardiac transplantation. Previously, we reported that the macrolide antibiotic rapamycin, but not the related compound FK506, inhibits both human and rat aortic SMC proliferation in vitro by inhibiting cell cycle-dependent kinases and delaying phosphorylation of retinoblastoma protein (Marx, S.O., T. Jayaraman, L.O. Go, and A.R. Marks. 1995. Circ. Res. 362:801). In the present study the effects of rapamycin on SMC migration were assayed in vitro using a modified Boyden chamber and in vivo using a porcine aortic SMC explant model. Pretreatment with rapamycin (2 ng/ml) for 48 h inhibited PDGF-induced migration (PDGF BB homodimer; 20 ng/ml) in cultured rat and human SMC (n = 10; P < 0.0001), whereas FK506 had no significant effect on migration. Rapamycin administered orally (1 mg/kg per d for 7 d) significantly inhibited porcine aortic SMC migration compared with control (n = 15; P < 0.0001). Thus, in addition to being a potent immunosuppressant and antiproliferative, rapamycin also inhibits SMC migration.
M Poon, S O Marx, R Gallo, J J Badimon, M B Taubman, A R Marks
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WS Speidl, KM Katsaros, SP Kastl, G Zorn, K Huber, G Maurer, J Wojta, G Christ |
Atherosclerosis | 2010 |
Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices
N Garg, N Goyal, TL Strawn, J Wu, KM Mann, DA Lawrence, WP Fay |
Journal of Thrombosis and Haemostasis | 2010 |
Tumor Suppressor Serine/Threonine Kinase LKB1 Expression, Not Kinase Activity, Increased in the Vascular Smooth Muscle Cells and Neointima in the Rat Carotid Artery Injury Model
JO Jeong, JH Kim, KT Ahn, HS Park, WI Jang, JH Park, JH Lee, SW Choi, JM Kim, IW Seong |
Korean Circulation Journal | 2010 |
Drug-eluting stents
X Ma, T Wu, MP Robich, X Wang, H Wu, B Buchholz, S McCarthy |
International journal of clinical and experimental medicine | 2010 |
The effects of rapamycin on lens epithelial cell proliferation, migration, and matrix formation: an in vitro study
H Liu, G Feng, L Wu, S Fu, P Liu, W Yang, X Zhang |
Molecular vision | 2010 |
mTOR signaling in cancer cell motility and tumor metastasis
H Zhou, S Huang |
Critical reviews in eukaryotic gene expression | 2010 |
Rapamycin inhibits re-endothelialization after percutaneous coronary intervention by impeding the proliferation and migration of endothelial cells and inducing apoptosis of endothelial progenitor cells
HT Liu, F Li, WY Wang, XJ Li, YM Liu, RA Wang, WY Guo, HC Wang |
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital | 2010 |
Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats
L Ma, S Ma, H He, D Yang, X Chen, Z Luo, D Liu, Z Zhu |
Hypertension Research | 2010 |
The Changes of Slit Diaphragm Molecules After Using Sirolimus
JY Choi, GD Han, YJ Kim, YH Park |
Journal of the Korean Society of Pediatric Nephrology | 2010 |
Coronary Stents
S Garg, PW Serruys |
Journal of the American College of Cardiology | 2010 |
Predictive value of C-reactive protein after drug-eluting stent implantation
RA Montone, G Ferrante, M Bacà, G Niccoli |
Future Cardiology | 2010 |
Preparation, characterization and in vitro anticoagulation of emodin-eluting controlled biodegradable stent coatings
CJ Pan, J Wang, N Huang |
Colloids and Surfaces B: Biointerfaces | 2010 |
Increased serum vWF and sVCAM-1 levels are associated with late or very late angiographic stent thrombosis after sirolimus-eluting stent implantation
C Jin, L Lu, ZB Zhu, RY Zhang, Q Zhang, R Du, FH Ding, QJ Chen, WF Shen |
Coronary Artery Disease | 2010 |
Increased Restenosis Rate After Implantation of Drug-Eluting Stents in Patients With Elevated Serum Activity of Matrix Metalloproteinase-2 and -9
KM Katsaros, SP Kastl, G Zorn, G Maurer, J Wojta, K Huber, G Christ, WS Speidl |
JACC: Cardiovascular Interventions | 2010 |
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
Impaired Peroxisome Proliferator-activated Receptor-γ Contributes to Phenotypic Modulation of Vascular Smooth Muscle Cells during Hypertension
L Zhang, P Xie, J Wang, Q Yang, C Fang, S Zhou, J Li |
The Journal of biological chemistry | 2010 |
Sirolimus Eluting Stents
PP Hu, E Mahmud |
Clinical medicine insights. Therapeutics | 2010 |
Biodegradable Sirolimus-loaded Poly(lactide) Nanoparticles as Drug Delivery System for the Prevention of In-Stent Restenosis in Coronary Stent Application
F Luderer, M Löbler, HW Rohm, C Gocke, K Kunna, K Köck, HK Kroemer, W Weitschies, KP Schmitz, K Sternberg |
Journal of Biomaterials Applications | 2010 |
Monitoring Molecular-Specific Pharmacodynamics of Rapamycin In vivo with Inducible Gal4 → Fluc Transgenic Reporter Mice
MH Pan, J Lin, JL Prior, D Piwnica-Worms |
Molecular cancer therapeutics | 2010 |
Smooth muscle Notch1 mediates neointimal formation after vascular injury
Y Li, K Takeshita, PY Liu, M Satoh, N Oyama, Y Mukai, MT Chin, L Krebs, MI Kotlikoff, F Radtke, T Gridley, JK Liao |
Circulation | 2009 |
Signaling Pathways Regulating Vascular Smooth Muscle Cell Differentiation
EM Rzucidlo |
Vascular | 2009 |
Molecular Basis of Restenosis and Novel Issues of Drug-Eluting Stents
T Inoue, K Node |
Circulation Journal | 2009 |
In-vitro Release of Rapamycin from a Thermosensitive Polymer for the Inhibition of Vascular Smooth Muscle Cell Proliferation
W Zhu, T Masaki, AK Cheung, SE Kern |
Journal of bioequivalence & bioavailability | 2009 |
Morelloflavone blocks injury-induced neointimal formation by inhibiting vascular smooth muscle cell migration
D Pinkaew, SG Cho, DY Hui, JE Wiktorowicz, N Hutadilok-Towatana, W Mahabusarakam, M Tonganunt, LJ Stafford, A Phongdara, M Liu, K Fujise |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2009 |
Spreading of mesothelioma cells is rapamycin-sensitive and requires continuing translation
E Ranzato, S Grosso, M Patrone, PG Betta, A Viarengo, S Biffo |
Journal of Cellular Biochemistry | 2009 |
Percutaneous coronary intervention with oral sirolimus and bare metal stents has comparable safety and efficacy to treatment with drug eluting stents, but with significant cost saving: long-term follow-up results from the randomised, controlled ORAR III (Oral Rapamycin in ARgentina) study
A Rodriguez, A Maree, S Tarragona, C Fernandez-Pereira, O Santaera, AR Granillo, G Rodriguez-Granillo, M Russo-Felssen, N Kukreja, D Antoniucci, I Palacios, P Serruys |
EuroIntervention | 2009 |
Rapamycin—rather than FK506—might promote allograft tolerance induced by CD4+CD25+ regulatory T cells
JF Du, SY Li, B Yu |
Surgery | 2009 |
Systemic rapamycin without loading dose for restenosis prevention after coronary bare metal stent implantation
S Stojkovic, M Ostojic, M Nedeljkovic, G Stankovic, B Beleslin, V Vukcevic, D Orlic, A Arandjelovic, J Kostic, M Dikic, M Tomasevic |
Catheterization and Cardiovascular Interventions | 2009 |
Therapeutic role of sirolimus in non-transplant kidney disease
GK Rangan, T Nguyen, R Mainra, L Succar, KG Schwensen, JS Burgess, KO Ho |
Pharmacology & Therapeutics | 2009 |
ADENOVIRUS-MEDIATED FKBP12.6 OVEREXPRESSION INDUCES HYPERTROPHY AND APOPTOSIS IN CULTURED NEONATAL CARDIOMYOCYTES
J Zhong, J Chen, T Cao, L Wang, W Zhang, D Liu, Z Zhu |
Clinical and Experimental Pharmacology and Physiology | 2009 |
Passive and Active Polymer Coatings for Intracoronary Stents: Novel Devices to Promote Arterial Healing
L Pendyala, R Jabara, K Robinson, N Chronos |
Journal of Interventional Cardiology | 2009 |
Comparison of the Systemic Levels of Inflammatory Markers after Percutaneous Coronary Intervention with Bare Metal versus Sirolimus-Eluting Stents
AG Rebeiz, E Zoghbi, R Harb, S Youhanna, HN Skouri, A Dimassi, G Abou-Nader, A Nasrallah, J Sawaya, W Gharzuddine, S Alam |
Journal of Interventional Cardiology | 2009 |
Optimization of Plasma Treatment, Manipulative Variables and Coating Composition for the Controlled Filling and Coating of a Microstructured Reservoir Stent
M Mekki, S Durual, SS Scherrer, J Lammers, HW Wiskott |
Journal of Medical Devices | 2009 |
A new strategy for prevention of anastomotic stricture using tacrolimus-eluting biodegradable nanofiber
M Mutsuga, Y Narita, A Yamawaki, M Satake, H Kaneko, Y Suematsu, A Usui, Y Ueda |
The Journal of Thoracic and Cardiovascular Surgery | 2009 |
Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor
L Zhao, T Ding, T Cyrus, Y Cheng, H Tian, M Ma, R Falotico, D Praticò |
British Journal of Pharmacology | 2009 |
Pharmacology and Therapeutics
BL Clarke, S Khosla |
Pharmacology & Therapeutics | 2009 |
New approach for local delivery of rapamycin by bioadhesive PLGA-carbopol nanoparticles
W Zou, G Cao, Y Xi, N Zhang |
Drug Delivery | 2009 |
Emerging drugs for coronary restenosis: the role of systemic oral agents the in stent era
AE Rodriguez |
Expert Opinion on Emerging Drugs | 2009 |
Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice
AL Gadioli, BV Nogueira, RM Arruda, RB Pereira, SS Meyrelles, JA Arruda, EC Vasquez |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2009 |
Drug-Eluting Stent for Delivery of Signal Pathway-Specific 1,3-Dipropyl-8-cyclopentyl Xanthine
E Kang, K Vedantham, X Long, M Dadara, IK Kwon, M Sturek, K Park |
Molecular Pharmaceutics | 2009 |
Device Therapy in Heart Failure
WH Maisel |
2009 | |
Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors
J Shan, TB Nguyen, H Totary-Jain, H Dansky, SO Marx, AR Marks |
Proceedings of the National Academy of Sciences | 2008 |
Lokale Medikamentenfreisetzung am und im Gefäß
A Larena-Avellaneda, G Dittmann, R Siegel, C Haacke, ES Debus |
Gefässchirurgie | 2008 |
Cytokines and Coronary Artery Disease
AA El-Menyar |
Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine | 2008 |
Migration of airway smooth muscle cells
WT Gerthoffer |
Proceedings of the American Thoracic Society | 2008 |
The inhibition of insulin-stimulated proliferation of vascular smooth muscle cells by rosiglitazone is mediated by the Akt-mTOR-P70S6K pathway
S Park, S Lim, W Chang, H Song, S Lee, BW Song, HJ Kim, MJ Cha, E Choi, Y Jang, N Chung, SY Cho, KC Hwang |
Yonsei Medical Journal | 2008 |
Phosphoinositide 3-kinase signalling in the vascular system
F Morello, A Perino, E Hirsch |
Cardiovascular Research | 2008 |
Comparison of vasa vasorum after intravascular stent placement with sirolimis drug-eluting and bare metal stents
LG Sahler, D Davis, WE Saad, NC Patel, DE Lee, DL Waldman |
Journal of Medical Imaging and Radiation Oncology | 2008 |
Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR−/− mice despite severe hypercholesterolemia
MA Mueller, F Beutner, D Teupser, U Ceglarek, J Thiery |
Atherosclerosis | 2008 |
Proliferation signal inhibitors and cardiac allograft vasculopathy
E Raichlin, SS Kushwaha |
Current Opinion in Organ Transplantation | 2008 |
Effects of rapamycin on intracellular cholesterol homeostasis of glomerular mesangial cell in the presence of interleukin-1β
G Zhang, H Li, X Li |
Chinese Medical Sciences Journal | 2008 |
Long-Term Coronary Endothelial Function After Zotarolimus-Eluting Stent Implantation
DI Shin, KB Seung, PJ Kim, K Chang, JK Choi, DS Jeon, MJ Kim, MY Lee, WS Chung |
International Heart Journal | 2008 |
Eluting characteristics of a platelet glycoprotein receptor antibody using a PLLA-coated stent
GX Wang, TY Yin, LL Luo, YB Hou, YZ Wang, CG Ruan, RP Guzman, R Guidoin |
Journal of Biomaterials Science, Polymer Edition | 2008 |
Sirolimus-induced vascular dysfunction. Increased mitochondrial and nicotinamide adenosine dinucleotide phosphate oxidase-dependent superoxide production and decreased vascular nitric oxide formation
A Jabs, S Göbel, P Wenzel, AL Kleschyov, M Hortmann, M Oelze, A Daiber, T Münzel |
Journal of the American College of Cardiology | 2008 |
Rapamycin inhibits proliferation and migration of hepatoma cells in vitro
Y Shirouzu, E Ryschich, O Salnikova, V Kerkadze, J Schmidt, G Engelmann |
The Journal of surgical research | 2008 |
Textbook of Peripheral Vascular Interventions, Second Edition: new approaches
E Kedhi, L Bilodeau |
Textbook of Peripheral Vascular Interventions, Second Edition | 2008 |
Nonimmunosuppressive effects of mammalian target of rapamycin inhibitors
JM Cruzado |
Transplantation Reviews | 2008 |
Are impaired endothelial progenitor cells involved in the processes of late in-stent thrombosis and re-endothelialization of drug-eluting stents?
FH Zhao, YD Chen, ZN Jin, SZ Lu |
Medical Hypotheses | 2008 |
Preliminary Results of the Hydroxyapatite Nonpolymer-Based Sirolimus-Eluting Stent for the Treatment of Single De Novo Coronary Lesions
JR Costa, A Abizaid, R Costa, F Feres, LF Tanajura, A Abizaid, LA Mattos, R Staico, D Siqueira, AG Sousa, R Bonan, JE Sousa |
JACC: Cardiovascular Interventions | 2008 |
Drug-eluting stents—what should be improved?
J Steffel, FR Eberli, TF Lüscher, FC Tanner |
Annals of Medicine | 2008 |
The critical role of the intrinsic VSMC proliferation and death programs in injury-induced neointimal hyperplasia
ZH Mnjoyan, D Doan, JL Brandon, K Felix, CL Sitter, AA Rege, TA Brock, K Fujise |
American journal of physiology. Heart and circulatory physiology | 2008 |
Interventional Treatment of Advanced Ischemic Heart Disease
R Delgado |
2008 | |
Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
R Paddenberg, P Stieger, AL Lilien, P Faulhammer, A Goldenberg, HH Tillmanns, W Kummer, RC Braun-Dullaeus |
Respiratory Research | 2007 |
Smooth muscle cell signal transduction: Implications of vascular biology for vascular surgeons
A Muto, TN Fitzgerald, JM Pimiento, SP Maloney, D Teso, JJ Paszkowiak, TS Westvik, FA Kudo, T Nishibe, A Dardik |
Journal of Vascular Surgery | 2007 |
Sirolimus blocks the accumulation of hyaluronan (HA) by arterial smooth muscle cells and reduces monocyte adhesion to the ECM
Y Gouëffic, S Potter-Perigo, CK Chan, PY Johnson, K Braun, SP Evanko, TN Wight |
Atherosclerosis | 2007 |
Preparation and characterization of rapamycin-loaded PLGA coating stent
CJ Pan, JJ Tang, YJ Weng, J Wang, N Huang |
Journal of Materials Science: Materials in Medicine | 2007 |
Angiographic and Clinical Outcome Following Sirolimus-Eluting Stent (Cypher) Implantation
T Ozcan, VG Cin, M Yurtdas, B Akcay, S Seyis, A Acele, D Cicek, A Camsari, N Akkus, O Doven |
International Heart Journal | 2007 |
Regulation of vascular smooth muscle cell differentiation
EM Rzucidlo, KA Martin, RJ Powell |
Journal of Vascular Surgery | 2007 |
Sesquiterpene Lactone Suppresses Vascular Smooth Muscle Cell Proliferation and Migration via Inhibition of Cell Cycle Progression
M Nakagawa, T Ohno, R Maruyama, M Okubo, A Nagatsu, M Inoue, H Tanabe, G Takemura, S Minatoguchi, H Fujiwara |
Biological & Pharmaceutical Bulletin | 2007 |
Drug-Eluting Stents
L Slavin, A Chhabra, JM Tobis |
Cardiology in Review | 2007 |
Orally Administered Rapamycin Does Not Modify Rat Aortic Vascular Tone
MM Neto, GS di Marco, DE Casarini, VC Lima, AH Campos |
Journal of Cardiovascular Pharmacology | 2007 |
Sirolimus-eluting coronary stents: a review
A Abizaid |
Vascular Health and Risk Management | 2007 |
Coronary stents: A materials perspective
G Mani, MD Feldman, D Patel, CM Agrawal |
Biomaterials | 2007 |
External Application of Rapamycin-Eluting Film at Anastomotic Sites Inhibits Neointimal Hyperplasia in a Canine Model
S Kawatsu, K Oda, Y Saiki, Y Tabata, K Tabayashi |
The Annals of Thoracic Surgery | 2007 |
Improved blood compatibility of rapamycin-eluting stent by incorporating curcumin
CJ Pan, JJ Tang, ZY Shao, J Wang, N Huang |
Colloids and Surfaces B: Biointerfaces | 2007 |
Enhanced inflammatory response to coronary stenting marks the development of clinically relevant restenosis
AM Caixeta, FS Brito, MA Costa, CV Serrano, JL Petriz, PL da Luz |
Catheterization and Cardiovascular Interventions | 2007 |
Targeting mammalian target of rapamycin (mTOR) for health and diseases
CK Tsang, H Qi, LF Liu, XF Zheng |
Drug Discovery Today | 2007 |
Clinical Use of Sirolimus-Eluting Stents
AJ Kirtane, MB Leon |
Cardiovascular Drug Reviews | 2007 |
Effects of controlled-released sirolimus from polymer matrices on human coronary artery smooth muscle cells
XT Wang, S Venkatraman, F Boey, SC Loo, LP Tan |
Journal of Biomaterials Science, Polymer Edition | 2007 |
Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations
M Prunotto, M Bacchetta, S Jayaraman, M Galloni, GV Eys, G Gabbiani, ML Bochaton-Piallat |
FEBS Letters | 2007 |
Local vascular dysfunction after coronary paclitaxel-eluting stent implantation
M Togni, L Räber, R Cocchia, P Wenaweser, S Cook, S Windecker, B Meier, OM Hess |
International Journal of Cardiology | 2007 |
The effects of granulocyte-colony stimulating factor in bare stent and sirolimus-eluting stent in pigs following myocardial infarction
SY Lim, YS Kim, Y Ahn, MH Jeong, LS Rok, JH Kim, KH Kim, HW Park, W Kim, JG Cho, JC Park, PM Kang, RS Schwartz, JC Kang |
International Journal of Cardiology | 2007 |
Sirolimus-Eluting Stents vs Uncoated Stents for the Treatment of Proximal Left Anterior Descending Coronary Artery Stenosis
J Valencia, V Mainar, P Bordes, A Berenguer, JM Ruiz-Nodar, J Pineda, S Gomez, F Sogorb, J Caturla |
International journal of biomedical science : IJBS | 2007 |
Sirolimus inhibits key events of restenosis in vitro/ex vivo: evaluation of the clinical relevance of the data by SI/MPL- and SI/DES-ratio's
R Voisard, S Zellmann, F Müller, F Fahlisch, L Müller, R Baur, J Braun, J Gschwendt, M Kountides, V Hombach, J Kamenz |
BMC Cardiovascular Disorders | 2007 |
Rapamycin Promotes Vascular Smooth Muscle Cell Differentiation through Insulin Receptor Substrate-1/Phosphatidylinositol 3-Kinase/Akt2 Feedback Signaling
KA Martin, BL Merenick, M Ding, KM Fetalvero, EM Rzucidlo, CD Kozul, DJ Brown, HY Chiu, M Shyu, BL Drapeau, RJ Wagner, RJ Powell |
The Journal of biological chemistry | 2007 |
Anti-atherosclerotic effects of sirolimus on human vascular smooth muscle cells
KL Ma, XZ Ruan, SH Powis, JF Moorhead, Z Varghese |
American journal of physiology. Heart and circulatory physiology | 2007 |
The Proline-rich Akt Substrate of 40 kDa (PRAS40) Is a Physiological Substrate of Mammalian Target of Rapamycin Complex 1
N Oshiro, R Takahashi, K Yoshino, K Tanimura, A Nakashima, S Eguchi, T Miyamoto, K Hara, K Takehana, J Avruch, U Kikkawa, K Yonezawa |
The Journal of biological chemistry | 2007 |
Cardiovascular Medicine
JT Willerson, HJ Wellens, JN Cohn, DR Holmes |
2007 | |
Effect of Rapamycin/Curcumin Co-Loaded Poly(Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation
J Wang, JJ Tang, L Ren, CJ Pan, N Huang |
Key Engineering Materials | 2007 |
Essentials of Restenosis
HJ Duckers, EG Nabel, PW Serruys |
2007 | |
Inflammatory responses involving tumor necrosis factor receptor-associated factor 6 contribute to in-stent lesion formation in a stent implantation model of rabbit carotid artery
T Miyahara, H Koyama, T Miyata, H Shigematsu, JI Inoue, T Takato, H Nagawa |
Journal of Vascular Surgery | 2006 |
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
L Liu, F Li, JA Cardelli, KA Martin, J Blenis, S Huang |
Oncogene | 2006 |
Effectiveness of a Sirolimus-Eluting Stent (Cypher ® ) for Diffuse In-Stent Restenosis Inside a Bare Metal Stent
H Sakamoto, T Ishikawa, M Mutoh, H Okada, T Tsurusaki, M Ohta, M Higashitani, Y Nakano, Y Fuda, K Imai, T Horie, S Mochizuki |
International Heart Journal | 2006 |
Safety and Pharmacokinetics of Sirolimus-eluting Stents in the Canine Cerebral Vasculature: 180 Day Assessment
EI Levy, RA Hanel, FO Tio, DS Garlick, L Bailey, MR Cunningham, C Williard, D Sherman, JF Dooley, GA Kopia |
Neurosurgery | 2006 |
Oral Rapamycin After Coronary Bare-Metal Stent Implantation to Prevent Restenosis
AE Rodriguez, JF Granada, M Rodriguez-Alemparte, CF Vigo, J Delgado, C Fernandez-Pereira, A Pocovi, AM Rodriguez-Granillo, D Schulz, AE Raizner, I Palacios, W O’Neill, GL Kaluza, G Stone |
Journal of the American College of Cardiology | 2006 |
The Paclitaxel-Eluting Stent in Percutaneous Coronary Intervention: Part II
GM Ray, JJ Nawarskas, WH Frishman |
Cardiology in Review | 2006 |
Dominant-negative Rac increases both inherent and ionizing radiation-induced cell migration in C6 rat glioma cells
SY Hwang, JW Jung, JS Jeong, YJ Kim, ES Oh, TH Kim, JY Kim, KH Cho, IO Han |
International Journal of Cancer | 2006 |
Sirolimus and Paclitaxel on Polymer-Based Drug-Eluting Stents
R Wessely, A Schömig, A Kastrati |
Journal of the American College of Cardiology | 2006 |
Coronary artery restenosis: vascular biology and emerging therapeutic strategies
K Sarkar, SK Sharma, R Sachdeva, F Romeo, L Garza, JL Mehta |
Expert Review of Cardiovascular Therapy | 2006 |
Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment
J Jozwiak, S Jozwiak, M Oldak |
Medicinal Research Reviews | 2006 |
The role and value of sirolimus administration in kidney and liver transplantation
A Mehrabi, H Fonouni, A Kashfi, BM Schmied, C Morath, M Sadeghi, P Schemmer, J Encke, P Sauer, M Zeier, J Weitz, MW Büchler, J Schmidt |
Clinical Transplantation | 2006 |
Effects of Tacrolimus or Sirolimus on Proliferation of Vascular Smooth Muscle and Endothelial Cells
CM Matter, I Rozenberg, A Jaschko, H Greutert, DJ Kurz, S Wnendt, B Kuttler, H Joch, J Gr??nenfelder, G Z??nd, FC Tanner, TF L??scher |
Journal of Cardiovascular Pharmacology | 2006 |
Controlled release of sirolimus from a multilayered PLGA stent matrix
X Wang, SS Venkatraman, FY Boey, JS Loo, LP Tan |
Biomaterials | 2006 |
Mycophenolate Mofetil and Sirolimus Combination in Renal Transplantation
JM Grinyo, JM Cruzado |
American Journal of Transplantation | 2006 |
Anesthesia for Pediatric Organ Transplantation
KM Robertson, AC Shukla, FX McGowan, DS Beebe, KG Belani, VL Scott |
Smith s Anesthesia for Infants and Children | 2006 |
Enzyme Inhibitors Series
M Boehm, M Crook |
Enzyme Inhibitors Series | 2006 |
Pathology of Drug-Eluting Stents in Humans
M Joner, AV Finn, A Farb, EK Mont, FD Kolodgie, E Ladich, R Kutys, K Skorija, HK Gold, R Virmani |
Journal of the American College of Cardiology | 2006 |
Liposome Technology, Volume II: Entrapment of Drugs and Other Materials into Liposomes, Third Edition
R Schumacher, G Spagnoli, M Adamina |
Liposome Technology, Volume II: Entrapment of Drugs and Other Materials into Liposomes, Third Edition | 2006 |
Recanalização da artéria femoral superficial com stents Zilver: técnica padronizada e análise retrospectiva de 3 anos
M Ferreira, LF Capotorto, G Abuhadba, M Monteiro, L Lanziotti |
Jornal Vascular Brasileiro | 2006 |
Pharmacological basis of different targets for the treatment of atherosclerosis
HK Saini, YJ Xu, AS Arneja, PS Tappia, NS Dhalla |
Journal of Cellular and Molecular Medicine | 2005 |
Sirolimus-Eluting Stents Associated With Paradoxic Coronary Vasoconstriction
M Togni, S Windecker, R Cocchia, P Wenaweser, S Cook, M Billinger, B Meier, OM Hess |
Journal of the American College of Cardiology | 2005 |
The drug-based pipeline against restenosis
PF Keller, R Ibrahim, JC Tardif |
Expert Opinion on Emerging Drugs | 2005 |
Efficacy of drug eluting stents in patients with and without diabetes mellitus: indirect comparison of controlled trials
C Stettler, S Allemann, M Egger, S Windecker, B Meier, P Diem |
Heart (British Cardiac Society) | 2005 |
Role of oral rapamycin to prevent restenosis in patients with de novo lesions undergoing coronary stenting: results of the Argentina single centre study (ORAR trial)
AE Rodríguez, MR Alemparte, CF Vigo, CF Pereira, C Llauradó, D Vetcher, A Pocovi, J Ambrose |
Heart (British Cardiac Society) | 2005 |
Drug-eluting stent: a review and update
T Htay, MW Liu |
Vascular Health and Risk Management | 2005 |
Altered trafficking of CD8+ memory T cells after implantation of rapamycin-eluting stents in patients with coronary artery disease
G Sardella, D Accapezzato, AD Roma, V Francavilla, CD Russo, G Iannucci, MI Sirinian, L Giacomelli, F Fedele, M Paroli |
Immunology Letters | 2005 |
Stents recubiertos y otros dispositivos antirreestenosis
R Moreno |
Revista Española de Cardiología | 2005 |
Cardiovascular risk profile in patients treated with sirolimus after renal transplantation
JM Morales |
Kidney International | 2005 |
Novel site-specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model
NN Kipshidze, TR Porter, G Dangas, H Yazdi, F Tio, F Xie, D Hellinga, R Wolfram, R Seabron, R Waksman, A Abizaid, G Roubin, S Iyer, A Colombo, MB Leon, JW Moses, P Iversen |
Catheterization and Cardiovascular Interventions | 2005 |
Rapamycin Attenuates Atherosclerotic Plaque Progression in Apolipoprotein E Knockout Mice
R Pakala, E Stabile, GJ Jang, L Clavijo, R Waksman |
Journal of Cardiovascular Pharmacology | 2005 |
A Prospective Randomized Trial of Steroid-Free Maintenance Regimens in Kidney Transplant Recipients-An Interim Analysis
R Kandaswamy, JK Melancon, T Dunn, M Tan, V Casingal, A Humar, WD Payne, RW Gruessner, DL Dunn, JS Najarian, DE Sutherland, KJ Gillingham, AJ Matas |
American Journal of Transplantation | 2005 |
Mycotic aneurysm of left anterior descending artery after sirolimus-eluting stent implantation: A case report
H Singh, C Singh, N Aggarwal, JS Dugal, A Kumar, M Luthra |
Catheterization and Cardiovascular Interventions | 2005 |
Stent Implantation Activates RhoA in Human Arteries: Inhibitory Effect of Rapamycin
P Guérin, V Sauzeau, M Rolli-Derkinderen, OA Habbash, E Scalbert, D Crochet, P Pacaud, G Loirand |
Journal of Vascular Research | 2005 |
Sphingosine-1-phosphate–induced smooth muscle cell migration involves the mammalian target of rapamycin
WJ Tanski, SM Nicholl, D Kim, AJ Fegley, E Roztocil, MG Davies |
Journal of Vascular Surgery | 2005 |
Drug-eluting stents: Sirolimus and paclitaxel differentially affect cultured cells and injured arteries
TJ Parry, R Brosius, R Thyagarajan, D Carter, D Argentieri, R Falotico, J Siekierka |
European Journal of Pharmacology | 2005 |
A novel drug-eluting stent spray-coated with multi-layers of collagen and sirolimus
MC Chen, HF Liang, YL Chiu, Y Chang, HJ Wei, HW Sung |
Journal of Controlled Release | 2005 |
Handbook of Drug-Eluting Stents: preclinical studies
A Carter, G Kopia, R Falotico |
Handbook of Drug-Eluting Stents: preclinical studies | 2005 |
Handbook of Drug-Eluting Stents
Y Yang, A Marks, S Marx |
Handbook of Drug-Eluting Stents: preclinical studies | 2005 |
Drug-Eluting Stents: Advanced Applications for the Management of Coronary Disease
A Chan |
Drug-Eluting Stents: Advanced Applications for the Management of Coronary Disease | 2005 |
Drug-Eluting Stents and Other Anti-Restenosis Devices
R Moreno |
Revista Española de Cardiología (English Edition) | 2005 |
Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin
K Sakakibara, B Liu, S Hollenbeck, KC Kent |
American journal of physiology. Heart and circulatory physiology | 2005 |
Heme oxygenase-1: a therapeutic amplification funnel
FH Bach |
The FASEB Journal | 2005 |
Diabetes and percutaneous coronary intervention in the setting of an acute coronary syndrome
DM Safley, SP Marso |
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease | 2005 |
Drug Eluting Stent Technology: A Paradigm Shift in the Treatment and Prevention of Restenosis
W Alvarez, NK Kapur |
Journal of Pharmacy Practice | 2005 |
mTOR-targeted therapy of cancer with rapamycin derivatives
S Vignot, S Faivre, D Aguirre, E Raymond |
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO | 2005 |
In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin
D MacMillan, S Currie, KN Bradley, TC Muir, JG McCarron |
Journal of cell science | 2005 |
Bone marrow-derived immune cells regulate vascular disease through a p27Kip1-dependent mechanism
Manfred Boehm, Michelle Olive, Andrea L. True, Martin F. Crook, Hong San, Xuan Qu, Elizabeth G. Nabel |
Journal of Clinical Investigation | 2004 |
Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27Kip1-independent pathway
C Castro, JM Campistol, D Sancho, F Sánchez-Madrid, E Casals, V Andrés |
Atherosclerosis | 2004 |
Drug-Eluting Stents: A Mechanical and Pharmacologic Approach to Coronary Artery Disease
PP Dobesh, ZA Stacy, AJ Ansara, JM Enders |
Pharmacotherapy | 2004 |
Perivascular delivery of neomycin inhibits the activation of NF-κB and MAPK pathways, and prevents neointimal hyperplasia and stenosis after arterial injury
J García-Trapero, F Carceller, M Dujovny, P Cuevas |
Neurological Research | 2004 |
Prevention of restenosis after coronary angioplasty
G Karthikeyan, B Bhargava |
Current Opinion in Cardiology | 2004 |
Local application of rapamycin inhibits neointimal hyperplasia in experimental vein grafts
T Schachner, Y Zou, A Oberhuber, A Tzankov, T Mairinger, G Laufer, JO Bonatti |
The Annals of Thoracic Surgery | 2004 |
Role of the p70S6K pathway in regulating the actin cytoskeleton and cell migration
LA Berven, FS Willard, MF Crouch |
Experimental Cell Research | 2004 |
Cell-cycle-dependent regulation of cell motility and determination of the role of Rac1
PS Walmod, R Hartmann-Petersen, S Prag, EL Lepekhin, C Röpke, V Berezin, E Bock |
Experimental Cell Research | 2004 |
TOR of the cell cycle: Are there important implications for diabetics in the era of the drug-eluting stent?
AJ Carter |
Catheterization and Cardiovascular Interventions | 2004 |
Oral rapamycin to inhibit restenosis after stenting of de novo coronary lesions
R Waksman, AE Ajani, AD Pichard, R Torguson, E Pinnow, D Canos, LF Satler, KM Kent, P Kuchulakanti, C Pappas, L Gambone, N Weissman, MC Abbott, J Lindsay |
Journal of the American College of Cardiology | 2004 |
Rapamycin suppresses experimental aortic aneurysm growth
DM Lawrence, RS Singh, DP Franklin, DJ Carey, JR Elmore |
Journal of Vascular Surgery | 2004 |
Importance of mammalian target of rapamycin inhibitors in the prevention of cardiac allograft vasculopathy
AM Keogh, PN Ruygrok |
Current Opinion in Organ Transplantation | 2004 |
Conjugation of an antibody to cross-linked fibrin for targeted delivery of anti-restenotic drugs
AC Thomas, JH Campbell |
Journal of Controlled Release | 2004 |
Du sirolimus au stent Cypher®: les étapes d'une victoire contre la restenose
I Fontes |
Annales de Cardiologie et d Angéiologie | 2004 |
Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling
S Hafizi, VN Mordi, KM Andersson, AH Chester, MH Yacoub |
Vascular Pharmacology | 2004 |
Case Studies in Interventional Cardiology: a Potential Cure of Restenosis
M Costa, A Abizaid, A Abizaid, R Staico, A Chaves, M Centemero, A Silva, A Sousa, J Sousa |
Case Studies in Interventional Cardiology: a Potential Cure of Restenosis | 2004 |
Dose-dependent Inhibition of Myointimal Hyperplasia by Orally Administered Rapamycin
N Uchimura, GB Perera, RM Fujitani, JM Tobis, S Ishimaru, SE Wilson, IL Gordon |
Annals of Vascular Surgery | 2004 |
Intimal Hyperplasia—Still Here after All These Years!
KC Kent, B Liu |
Annals of Vascular Surgery | 2004 |
Preventing restenosis in early drug-eluting stent era: recent developments and future perspectives
P Birkenhauer, Z Yang, B Gander |
Journal of Pharmacy and Pharmacology | 2004 |
The Rapamycin derivative RAD inhibits mesangial cell migration through the CDK-inhibitor p27KIP1
C Daniel, J Pippin, SJ Shankland, C Hugo |
Laboratory Investigation | 2004 |
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
DC Fingar, J Blenis |
Oncogene | 2004 |
The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation
KA Martin, EM Rzucidlo, BL Merenick, DC Fingar, DJ Brown, RJ Wagner, RJ Powell |
American journal of physiology. Cell physiology | 2004 |
Effect of sirolimus on renal ischaemia/reperfusion injury in normotensive and hypertensive rats
O Viklick, R Bohmov, N Ouyang, E Honsov, A Lodererov, V Mandys, tefan Vtko, J Lutz, UW Heemann |
Transplant International | 2004 |
Inhibition of Mammalian Target of Rapamycin Activates Apoptosis Signal-regulating Kinase 1 Signaling by Suppressing Protein Phosphatase 5 Activity
S Huang, L Shu, J Easton, FC Harwood, GS Germain, H Ichijo, PJ Houghton |
The Journal of biological chemistry | 2004 |
Rapamycin plays a new role as differentiator of vascular smooth muscle phenotype. Focus on “The mTOR/p70 S6K1 pathway regulates vascular smooth muscle differentiation”
PA Lucchesi |
American journal of physiology. Cell physiology | 2004 |
BK Virus-Associated Nephropathy in Renal Allograft Recipients: Rescue Therapy by Sirolimus-Based Immunosuppression:
RK Wali, C Drachenberg, HH Hirsch, J Papadimitriou, A Nahar, V Mohanlal, MA Brisco, ST Bartlett, MR Weir, E Ramos |
Transplantation | 2004 |
Therapeutic Potential of Oral Antiproliferative Agents in the Prevention of Coronary Restenosis:
P Kuchulakanti, R Waksman |
Drugs | 2004 |
Investigation of Pediatric Renal Transplant Recipients with Heavy Proteinuria after Sirolimus Rescue:
L Butani |
Transplantation | 2004 |
Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty
TG Nührenberg, R Voisard, F Fahlisch, M Rudelius, J Braun, J Gschwend, M Kountides, T Herter, R Baur, V Hombach, PA Baeuerle, D Zohlnhöfer |
The FASEB Journal | 2004 |
Therapeutic potential of active stent coating
H Wieneke, A Schmermund, C Birgelen, M Haude, R Erbel |
Expert Opinion on Investigational Drugs | 2003 |
New approaches to preventing restenosis
B Bhargava, G Karthikeyan, AS Abizaid, R Mehran |
BMJ (Clinical research ed.) | 2003 |
Drug-eluting stents for cardiovascular disorders
JF Granada, GL Kaluza, A Raizner |
Current Atherosclerosis Reports | 2003 |
Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells
D Bruemmer, F Yin, J Liu, T Kiyono, E Fleck, AJ van Herle, RE Law |
Biochemical and Biophysical Research Communications | 2003 |
Angiographic regression of cardiac allograft vasculopathy after introducing sirolimus immunosuppression
PN Ruygrok, B Webber, S Faddy, DW Muller, A Keogh |
The Journal of Heart and Lung Transplantation | 2003 |
Rapamycin in cardiovascular medicine
PN Ruygrok, DW Muller, PW Serruys |
Internal Medicine Journal | 2003 |
Sirolimus for the Prevention of In-Stent Restenosis in a Coronary Artery
AR Marks |
New England Journal of Medicine | 2003 |
Surface engineering of biomaterials with plasma techniques
F Poncin-Epaillard, G Legeay |
Journal of Biomaterials Science, Polymer Edition | 2003 |
Effect of systemic immunosuppression on coronary in-stent intimal hyperplasia in renal transplant patients
JA Arruda, MA Costa, FS Brito, H Tedesco, AH Barbosa, ÉP Ribeiro, JO Pestana, VC Lima |
The American Journal of Cardiology | 2003 |
Stent-based immunosuppressive therapies for the prevention of restenosis
M Aggarwal, PS Tsao, A Yeung, AJ Carter |
Cardiovascular Radiation Medicine | 2003 |
Drugs and the Pharmaceutical Sciences
D Thompson |
Drugs and the Pharmaceutical Sciences | 2003 |
Rapamycin: signaling in vascular smooth muscle
AR Marks |
Transplantation Proceedings | 2003 |
Sirolimus therapy in cardiac transplantation
B Radovancevic, B Vrtovec |
Transplantation Proceedings | 2003 |
Oral rapamycin inhibits growth of atherosclerotic plaque in apoE knock-out mice
R Waksman, R Pakala, MS Burnett, CP Gulick, L Leborgne, J Fournadjiev, R Wolfram, D Hellinga |
Cardiovascular Radiation Medicine | 2003 |
Use of rapamycin-impregnated stents in coronary arteries
JE Sousa, AG Sousa, MA Costa, AC Abizaid, F Feres |
Transplantation Proceedings | 2003 |
Sirolimus in liver transplantation
JF Trotter |
Transplantation Proceedings | 2003 |
Sirolimus changes lipid concentrations and lipoprotein metabolism in kidney transplant recipients
JD Morrisett, G Abdel-Fattah, BD Kahan |
Transplantation Proceedings | 2003 |
Effect of carvedilol alone or in the presence of cyclosporine on the migration of vascular smooth muscle cell of rat
MS Kim, H Ha, YS Kim, J Park, H Kim, J Seo, JH Lee, K Park |
Transplantation Proceedings | 2003 |
Targeting the cell cycle machinery for the treatment of cardiovascular disease
KA Bicknell, EL Surry, G Brooks |
Journal of Pharmacy and Pharmacology | 2003 |
Inflammation and restenosis: implications for therapy
MM Donners, MJ Daemen, KB Cleutjens, S Heeneman |
Annals of Medicine | 2003 |
Sirolimus as primary immunosuppression in liver transplantation is not associated with hepatic artery or wound complications
J Dunkelberg |
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society | 2003 |
Interligação entre cardiologia intervencionista e cirurgia experimental
JE Souza |
Acta Cirurgica Brasileira | 2003 |
Transgene delivery of plasmid DNA to smooth muscle cells and macrophages from a biostable polymer-coated stent
A Takahashi, M Palmer-Opolski, RC Smith, K Walsh |
Gene Therapy | 2003 |
The Sirolimus-Eluting Stent: A Review of Its Use in the Treatment of Coronary Artery Disease
K McKeage, D Murdoch, KL Goa |
American Journal Cardiovascular Drugs | 2003 |
Development of a Water-Soluble Matrix Metalloproteinase Inhibitor as an Intra-arterial Infusion Drug for Prevention of Restenosis after Angioplasty
T Masuda, Y Nakayama |
Journal of Medicinal Chemistry | 2003 |
Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies
VJ Dzau, RC Braun-Dullaeus, DG Sedding |
Nature Medicine | 2002 |
New approaches to immunosuppression in liver transplantation
S Goddard, DH Adams |
Journal of Gastroenterology and Hepatology | 2002 |
Rapamycin eluting stent: the onset of a new era in interventional cardiology
PW Serruys, E Regar, AJ Carter |
Heart (British Cardiac Society) | 2002 |
Viewpoint Overcoming restenosis with sirolimus: from alphabet soup to clinical reality
M Poon, JJ Badimon, V Fuster |
The Lancet | 2002 |
Stent-based antirestenotic coatings (sirolimus/paclitaxel)
M Oberhoff, C Herdeg, A Baumbach, KR Karsch |
Catheterization and Cardiovascular Interventions | 2002 |
Everolimus in renal transplantation
TR Srinivas, HU Meier-Kriesche, B Kaplan |
Current Opinion in Organ Transplantation | 2002 |
Coronary artery stents: Evaluating new designs for contemporary percutaneous intervention
DE Kandzari, JE Tcheng, JP Zidar |
Catheterization and Cardiovascular Interventions | 2002 |
Sirolimus-Eluting Coronary Stents
PD Feyter, P Smits, B Rensing, J Vos, WJ van der Giessen, G Sianos, PW Serruys |
Journal of Interventional Cardiology | 2002 |
A clinical survey of vascular stents
SH Duda, B Wiesinger, C Koenig, J Wiskirchen, T Dietrich, G Tepe |
Minimally Invasive Therapy & Allied Technologies | 2002 |
Quantification of Sirolimus by Liquid Chromatography-Tandem Mass Spectrometry Using On-Line Solid-Phase Extraction
M Vogeser, C Fleischer, B Meiser, J Groetzner, U Spöhrer, D Seidel |
Clinical Chemistry and Laboratory Medicine | 2002 |
Smooth muscle cells on the move: the battle for actin
PA Doevendans, G Eys |
Cardiovascular Research | 2002 |
Fate of side branches after coronary arterial sirolimus-eluting stent implantation
K Tanabe, PW Serruys, M Degertekin, E Regar, RT van Domburg, JE Sousa, E Wülfert, MC Morice |
The American Journal of Cardiology | 2002 |
El estudio ravel. Reestenosis del cero por ciento: ¡un sueño del cardiólogo hecho realidad!
E Regar, PW Serruys |
Revista Española de Cardiología | 2002 |
Cardiovascular risk factors associated with immunosuppression in renal transplantation
BL Kasiske, CM Ballantyne |
Transplantation Reviews | 2002 |
Role of smooth muscle cell migration and proliferation in allograft vascular disease
M Roqué, ED Reis, E Roig |
Transplantation Proceedings | 2002 |
Drug-eluting stents for the prevention of restenosis: In quest for the holy grail
BL Hiatt, F Ikeno, AC Yeung, AJ Carter |
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions | 2002 |
CDKS and CKIS: Molecular targets for tissue remodelling
EG Nabel |
Nature Reviews Drug Discovery | 2002 |
No delayed restenosis at 18 months after implantation of sirolimus-eluting stent
K Tanabe, M Degertekin, E Regar, JM Ligthart, WJ van der Giessen, PW Serruys |
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions | 2002 |
Sirolimus-Eluting Stents for the Treatment of Obstructive Superficial Femoral Artery Disease: Six-Month Results
SH Duda, B Pusich, G Richter, P Landwehr, VL Oliva, A Tielbeek, B Wiesinger, JB Hak, H Tielemans, G Ziemer, E Cristea, A Lansky, JP Bérégi |
Circulation | 2002 |
Oral Everolimus Inhibits In-Stent Neointimal Growth
A Farb, M John, E Acampado, FD Kolodgie, MF Prescott, R Virmani |
Circulation | 2002 |
Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients
JD Morrisett, G Abdel-Fattah, R Hoogeveen, E Mitchell, CM Ballantyne, HJ Pownall, AR Opekun, JS Jaffe, S Oppermann, BD Kahan |
Journal of lipid research | 2002 |
Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin
RC Braun-Dullaeus, MJ Mann, U Seay, L Zhang, HE von der Leyen, RE Morris, VJ Dzau |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Long-term immunosuppressive strategy in the new millennium of renal transplantation
S Gourishankar, P Halloran |
Current Opinion in Organ Transplantation | 2001 |
Effects of local cytochalasin D delivery on smooth muscle cell migration and on collar-induced intimal hyperplasia in the rabbit carotid artery
RH Bruijns, H Bult |
British Journal of Pharmacology | 2001 |
Pharmacological treatment for prevention of restenosis
J Linde, BH Strauss |
Expert Opinion on Emerging Drugs | 2001 |
From Beach to Bedside: History of the Development of Sirolimus
KL Napoli, PJ Taylor |
Therapeutic Drug Monitoring | 2001 |
Effect of p27 Deficiency and Rapamycin on Intimal Hyperplasia: In Vivo and In Vitro Studies Using a p27 Knockout Mouse Model
M Roqué, ED Reis, C Cordon-Cardo, MB Taubman, JT Fallon, V Fuster, JJ Badimon |
Laboratory Investigation | 2001 |
Handbook of Coronary Stents, Fourth Edition: Clinical Data
M Costa, J Sousa |
Handbook of Coronary Stents, Fourth Edition: Clinical Data | 2001 |
Handbook of Coronary Stents, Fourth Edition: Preclinical Data
A Carter, R Falotico |
Handbook of Coronary Stents, Fourth Edition: Preclinical Data | 2001 |
Stent development and local drug delivery
E Regar, G Sianos, PW Serruys |
British Medical Bulletin | 2001 |
Inhibition of p70 S6 Kinase during Transforming Growth Factor-β1/Vitamin D 3 -induced Monocyte Differentiation of HL-60 Cells Allows Tumor Necrosis Factor-α to Stimulate Plasminogen Activator Inhibitor-1 Synthesis
F Peiretti, S Lopez, P Deprez-Beauclair, B Bonardo, I Juhan-Vague, G Nalbone |
The Journal of biological chemistry | 2001 |
Role for p27 Kip1 in Vascular Smooth Muscle Cell Migration
J Sun, SO Marx, HJ Chen, M Poon, AR Marks, LR Rabbani |
Circulation | 2001 |
Cell Cycle and Cell Migration: New Pieces to the Puzzle
M Boehm, EG Nabel |
Circulation | 2001 |
Stent-Based Delivery of Sirolimus Reduces Neointimal Formation in a Porcine Coronary Model
T Suzuki, G Kopia, S Hayashi, LR Bailey, G Llanos, R Wilensky, BD Klugherz, G Papandreou, P Narayan, MB Leon, AC Yeung, F Tio, PS Tsao, R Falotico, AJ Carter |
Circulation | 2001 |
Lack of Neointimal Proliferation After Implantation of Sirolimus-Coated Stents in Human Coronary Arteries: A Quantitative Coronary Angiography and Three-Dimensional Intravascular Ultrasound Study
JE Sousa, MA Costa, A Abizaid, AS Abizaid, F Feres, IM Pinto, AC Seixas, R Staico, LA Mattos, AG Sousa, R Falotico, J Jaeger, JJ Popma, PW Serruys |
Circulation | 2001 |
Bench to Bedside: The Development of Rapamycin and Its Application to Stent Restenosis
SO Marx, AR Marks |
Circulation | 2001 |
Sustained Suppression of Neointimal Proliferation by Sirolimus-Eluting Stents: One-Year Angiographic and Intravascular Ultrasound Follow-Up
JE Sousa, MA Costa, AC Abizaid, BJ Rensing, AS Abizaid, LF Tanajura, K Kozuma, GV Langenhove, AG Sousa, R Falotico, J Jaeger, JJ Popma, PW Serruys |
Circulation | 2001 |
Cardiac Allograft Rejection
GW Dec, J Narula, M Ballester, I Carrio |
2001 | |
Current treatment practice in immunosuppression
G Ciancio, GW Burke, J Miller |
Expert Opinion on Pharmacotherapy | 2000 |
Modulation of apoptosis, proliferation, and p27 expression in a porcine coronary angioplasty model
M Roque, C Cordon-Cardo, V Fuster, ED Reis, M Drobnjak, JJ Badimon |
Atherosclerosis | 2000 |
Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening
TS Ikonen, JF Gummert, N Serkova, M Hayase, Y Honda, Y Kobayase, B Hausen, PG Yock, U Christians, RE Morris |
Transplant International | 2000 |
Interleukin-8 Gene Repression by Clarithromycin Is Mediated by the Activator Protein-1 Binding Site in Human Bronchial Epithelial Cells
S Abe, H Nakamura, S Inoue, H Takeda, H Saito, S Kato, N Mukaida, K Matsushima, H Tomoike |
American journal of respiratory cell and molecular biology | 2000 |
α 2 Integrin Subunit Cytoplasmic Domain-dependent Cellular Migration Requires p38 MAPK
PA Klekotka, SA Santoro, MM Zutter |
The Journal of biological chemistry | 2000 |
Maintenance Immunosuppression: New Agents and Persistent Dilemmas
JM Gonin |
Advances in renal replacement therapy | 2000 |
SDZ-RAD PREVENTS MANIFESTATION OF CHRONIC REJECTION IN RAT RENAL ALLOGRAFTS:
O Viklick, H Zou, V Muller, J Lacha, A Szab, U Heemann |
Transplantation | 2000 |
SIROLIMUS (RAPAMYCIN) HALTS AND REVERSES PROGRESSION OF ALLOGRAFT VASCULAR DISEASE IN NON-HUMAN PRIMATES1:
TS Ikonen, JF Gummert, M Hayase, Y Honda, B Hausen, U Christians, GJ Berry, PG Yock, RE Morris |
Transplantation | 2000 |
Phosphatidylinositol 3-Kinase Is Required for Insulin-Like Growth Factor-I–Induced Vascular Smooth Muscle Cell Proliferation and Migration
C Duan, JR Bauchat, T Hsieh |
Circulation research | 2000 |
Drug Discovery from Nature
S Grabley, R Thiericke |
2000 | |
The therapeutic prescription for the organ transplant recipient: the linkage of immunosuppression and antimicrobial strategies
RH Rubin, T Ikonen, JF Gummert, RE Morris |
Transplant Infectious Disease | 1999 |
Kinase targets in inflammation
PA Scherle, JM Trzaskos |
Expert Opinion on Therapeutic Targets | 1999 |
Potential utility of rapamycin and tacrolimus in long-term, low-toxicity regimens
RS Gaston |
Transplantation Proceedings | 1999 |
Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries by Targeting Regulators of the Cell Cycle
R Gallo, A Padurean, T Jayaraman, S Marx, M Roque, S Adelman, J Chesebro, J Fallon, V Fuster, A Marks, JJ Badimon |
Circulation | 1999 |
A Macrolide Antibiotic, Roxithromycin, Inhibits the Growth of Nasal Polyp Fibroblasts
M Nonaka, R Pawankar, S Tomiyama, T Yagi |
American journal of rhinology | 1999 |
Newer Immunosuppressive Drugs: A Review
JF Gummert, T Ikonen, RE Morris |
Journal of the American Society of Nephrology : JASN | 1999 |
Growth factors and transplant vascular disease
S Saito, H Lou, PW Ramwell, ML Foegh |
Transplantation Reviews | 1998 |
Cell cycle progression: new therapeutic target for vascular proliferative disease
RC Braun-Dullaeus, MJ Mann, VJ Dzau |
Circulation | 1998 |
Platelet-Derived Growth Factor-BB, Insulin-like Growth Factor-I, and Phorbol Ester Activate Different Signaling Pathways for Stimulation of Vascular Smooth Muscle Cell Migration
L Pukac, J Huangpu, MJ Karnovsky |
Experimental Cell Research | 1998 |
Medical therapies for the prevention of restenosis after percutaneous coronary interventions
WH Frishman, R Chiu, BR Landzberg, M Weiss |
Current Problems in Cardiology | 1998 |