JCI - Citations to Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study.

Citations to this article

Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study.

A B Guttormsen, … , S E Vollset, H Refsum

A B Guttormsen, … , S E Vollset, H Refsum

Published November 1, 1996
Citation Information: J Clin Invest. 1996;98(9):2174-2183. https://doi.org/10.1172/JCI119024.

View: Text | PDF

Research Article

Total citations by year

Year:	2024	2023	2017	2016	2015	2014	2013	2011	2010	2009	2008	2007	2006	2005	2004	2003	2002	2001	2000	1999	1998	1997	1995	1979	Total
Citations:	1	1	3	2	1	2	2	3	3	5	5	5	7	8	6	16	13	27	19	16	21	7	1	1	175

Citation information

Citations to this article (175)

Title and authors	Publication	Year
An Update on Glutathione's Biosynthesis, Metabolism, Functions, and Medicinal Purposes. Gasmi A, Nasreen A, Lenchyk L, Lysiuk R, Peana M, Shapovalova N, Piscopo S, Komisarenko M, Shanaida M, Smetanina K, Antonyak H, Fira L, Lykhatskyi P, Fira D, Bjørklund G	Current medicinal chemistry	2024
Daily Folic Acid and/or Vitamin B12 Supplementation Between 6 and 30 Months of Age and Cardiometabolic Risk Markers After 6-7 Years: A Follow-Up of a Randomized Controlled Trial. Manapurath R, Strand TA, Chowdhury R, Kvestad I, Yajnik CS, Bhandari N, Taneja S	The Journal of nutrition	2023
Moderately Elevated Homocysteine Does Not Contribute to Thoracic Aortic Aneurysm in Mice J Roohi, B Kang, D Bernard, D Bedja, HC Dietz, LC Brody	The Journal of nutrition	2017
Vitamin Status and the Development of Postoperative Cognitive Decline in Elderly Surgical Oncologic Patients LB Weerink, BL van Leeuwen, SA Gernaat, AR Absalom, MG Huisman, HW der Huisman, GJ Izaks, GH de Bock	Annals of Surgical Oncology	2017
Manifestations of neurological symptoms and thromboembolism in adults with MTHFR-deficiency PS Rommer, J Zschocke, B Fowler, M Födinger, V Konstantopoulou, D Möslinger, E Stögmann, E Suess, M Baumgartner, E Auff, G Sunder-Plassmann	Journal of the Neurological Sciences	2017
Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer’s Disease B Troesch, P Weber, M Mohajeri	Nutrients	2016
Maternal-Fetal Evidence Based Guidelines, 3e V Berghella		2016
Integrative Therapies for Depression: Redefining Models for Assessment, Treatment and Prevention J Greenblatt, P Patel	Integrative Therapies for Depression: Redefining Models for Assessment, Treatment and Prevention	2015
Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota – The “RISTOMED project”: Randomized controlled trial in healthy older people L Valentini, A Pinto, I Bourdel-Marchasson, R Ostan, P Brigidi, S Turroni, S Hrelia, P Hrelia, S Bereswill, A Fischer, E Leoncini, M Malaguti, C Blanc-Bisson, J Durrieu, L Spazzafumo, F Buccolini, F Pryen, LM Donini, C Franceschi, H Lochs	Clinical Nutrition	2014
Hyperhomocysteinemia: Related genetic diseases and congenital defects, abnormal DNA methylation and newborn screening issues V Iacobazzi, V Infantino, A Castegna, G Andria	Molecular Genetics and Metabolism	2014
MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study A Hishida, R Okada, Y Guang, M Naito, K Wakai, S Hosono, K Nakamura, TC Turin, S Suzuki, H Niimura, H Mikami, J Otonari, N Kuriyama, S Katsuura, M Kubo, H Tanaka, N Hamajima	International Urology and Nephrology	2013
Effect of multivitamins on plasma homocysteine in patients with the 5,10 methylenetetrahydrofolate reductase C677T homozygous state D Delledera, A Tinelli, GN Milazzo, A Malvasi, C Domenico, E Pacella, C Pierluigi, T Giuseppe, G Marcello, L Francesco, AA Epifania	Molecular medicine reports	2013
A Patient with Congenital Generalized Lipodystrophy Due To a Novel Mutation in BSCL2: Indications for Secondary Mitochondrial Dysfunction Jeninga EH, de Vroede M, Hamers N, Breur JM, Verhoeven-Duif NM, Berger R, Kalkhoven E	JIMD reports	2011
Genotype-independent in vivo oxidative stress following a methionine loading test: Maximal platelet activation in subjects with early-onset thrombosis MN di Minno, S Pezzullo, V Palmieri, A Coppola, A D'Angelo, F Sampietro, V Cavalca, E Tremoli, GD Minno	Thrombosis Research	2011
Glycine and L-arginine treatment causes hyperhomocysteinemia in cerebral creatine transporter deficiency patients. Villar C, Campistol J, Fons C, Armstrong J, Mas A, Ormazabal A, Artuch R	JIMD reports	2011
A community based study of the relationship between homocysteine and some of the life style factors M Das, M Ghose, NC Borah, N Choudhury	Indian journal of clinical biochemistry : IJCB	2010
Gastric Cancer Susceptibility according to Methylenetetrahydrofolate Reductase and Thymidylate Synthase Gene Polymorphism H Jung, JI Lee, HH Lee, SH Kim, H Hur, HM Jeon	Journal of the Korean Surgical Society	2010
Frequency of the MTHFR C677T Polymorphism in Yemeni Children with Sickle Cell Disease AW Al-Saqladi, G Harper, A Delpisheh, K Fijnvandraat, HA Bin-Gadeem, BJ Brabin	Hemoglobin	2010
Age-related alteration of risk profile, inflammatory response, and angiographic findings in patients with acute coronary syndrome HM Badran, MF Elnoamany, TS Khalil, MM Eldin	Clinical medicine. Cardiology	2009
Methylenetetrahydrofolate reductase gene polymorphism in diabetes and obesity JT Bazzaz, M Shojapoor, H Nazem, P Amiri, H Fakhrzadeh, R Heshmat, M Parvizi, SH Ranjbar, MM Amoli	Molecular Biology Reports	2009
Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data LE Mitchell, M Morales, S Khartulyari, Y Huang, K Murphy, M Mei, JM von Feldt, IA Blair, AS Whitehead	Clinical Biochemistry	2009
Homocisteína en la clínica humana CA Errasti, MV Arberas, AM Berriotxoa	Medicina Clínica	2009
Age-Related Alteration of Risk Profile, Inflammatory Response, and Angiographic Findings in Patients with Acute Coronary Syndrome HM Badran, MF Elnoamany, TS Khalil, MM Eldin	Clinical medicine. Cardiology	2009
Series in Maternal-Fetal Medicine BE Metzger	Textbook of Diabetes and Pregnancy	2008
Homocysteine,MTHFR gene polymorphisms, and cardio-cerebrovascular risk E Trabetti	Journal of Applied Genetics	2008
Two siblings with a homozygous MTHFR C677T (G80A-RFC1) mutation and stroke M Barbagallo, P Pavone, G Incorpora, AD Praticò, O Romantshik, S Friso, A Spalice, F Nicita, A Polizzi, M Ruggieri, P Iannetti	Child's Nervous System	2008
Association of Methylenetetrahydrofolate Reductase C677T, A1298C, and G1793A Polymorphism and the Risk of Colon Cancer DB Kang, JK Rhee, WC Park	Journal of the Korean Society of Coloproctology	2008
The utility of thrombophilia testing in pregnant women with thrombosis: fact or fiction? CM Scifres, GA Macones	American Journal of Obstetrics and Gynecology	2008
The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism S Hustad, Ø Midttun, J Schneede, SE Vollset, T Grotmol, PM Ueland	The American Journal of Human Genetics	2007
Handbook of Nutrition and Food, Second Edition C Berdanier	Handbook of Nutrition and Food, Second Edition	2007
Physical activity is inversely associated with total homocysteine levels, independent of C677T MTHFR genotype and plasma B vitamins R Dankner, A Chetrit, GK Dror, BA Sela	Age (Dordrecht, Netherlands)	2007
Plasma Homocysteine, Folate, and Vitamin B12 and the Risk of Hip Fracture: The Hordaland Homocysteine Study CG Gjesdal, SE Vollset, PM Ueland, H Refsum, HE Meyer, GS Tell	Journal of Bone and Mineral Research	2007
Hyperhomocysteinemia and Thrombosis: An Overview MM Eldibany, JA Caprini	Archives of pathology & laboratory medicine	2007
Air pollution, smoking, and plasma homocysteine A Baccarelli, A Zanobetti, I Martinelli, P Grillo, L Hou, G Lanzani, PM Mannucci, PA Bertazzi, J Schwartz	Environmental Health Perspectives	2006
The screening power of methylenetetrahydrofolate reductase C677T polymorphism versus plasma homocysteine concentration in patients with stenosis of the internal carotid artery R Loncar, BT Müller, RB Zotz, C Sucker, W Sandmann, RE Scharf	Thrombosis Journal	2006
Serum homocysteine is related to food intake in adolescents: the Child and Adolescent Trial for Cardiovascular Health PL Lutsey, LM Steffen, HA Feldman, DH Hoelscher, LS Webber, RV Luepker, LA Lytle, M Zive, SK Osganian	The American journal of clinical nutrition	2006
Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele C Rendeli, E Ausili, M Castorina, D Antuzzi, F Tabacco, M Caldarelli	Child's Nervous System	2006
Erythrocyte membrane Na+,K+-ATPase and Mg2+-ATPase activities in subjects with methylenetetrahydrofolate reductase (MTHFR) 677 C→T genotype and moderate hyperhomocysteinaemia. The role of L-phenylalanine and L-alanine KH Schulpis, A Giannoulia-Karantana, ED Papaconstantinou, T Parthimos, I Tjamouranis, S Tsakiris	Clinical Chemistry and Laboratory Medicine	2006
Effects of Riboflavin and Folic Acid Supplementation on Plasma Homocysteine Levels in Healthy Subjects CZ Chuang, A Boyles, B LeGardeur, J Su, S Japa, A Lopez-S	The American Journal of the Medical Sciences	2006
The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease H Refsum, E Nurk, AD Smith, PM Ueland, CG Gjesdal, I Bjelland, A Tverdal, GS Tell, O Nygård, SE Vollset	The Journal of nutrition	2006
Relationship between polymorphisms in genes involved in homocysteine metabolism and maternal risk for Down syndrome in Brazil LR da Silva, N Vergani, LC Galdieri, MP Porto, SB Longhitano, D Brunoni, V D'Almeida, AB Perez	American Journal of Medical Genetics Part A	2005
Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype A Coppola, A D'Angelo, I Fermo, G Mazzola, MN di Minno, A Cajani, A Sala, G Folco, E Tremoli, GD Minno	British Journal of Haematology	2005
Homocysteine and folate metabolism in depression T Bottiglieri	Progress in Neuro-Psychopharmacology and Biological Psychiatry	2005
Plasma Hyperhomocysteinemia, MTHFR Polymorphism and Thromboembolic Disease: An Example of Gene-nutrition Interactions in Chronic Disease NF Chu	Journal of the Chinese Medical Association	2005
Thrombophilias and recurrent pregnancy loss: a critical appraisal of the literature I Krabbendam, A Franx, ML Bots, R Fijnheer, HW Bruinse	European Journal of Obstetrics & Gynecology and Reproductive Biology	2005
An association of 5,10-Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphism and ischemic stroke R Kawamoto, K Kohara, Y Oka, H Tomita, Y Tabara, T Miki	Journal of Stroke and Cerebrovascular Diseases	2005
Polymorphisms in Cytoplasmic Serine Hydroxymethyltransferase and Methylenetetrahydrofolate Reductase Affect the Risk of Cardiovascular Disease in Men U Lim, K Peng, B Shane, PJ Stover, AA Litonjua, ST Weiss, JM Gaziano, RL Strawderman, F Raiszadeh, J Selhub, KL Tucker, PA Cassano	The Journal of nutrition	2005
Homocysteine and Its Effects on In-Stent Restenosis GD Luca, H Suryapranata, G Gregorio, H Lange, M Chiariello	Circulation	2005
SULFUR AMINO ACID METABOLISM: Pathways for Production and Removal of Homocysteine and Cysteine MH Stipanuk	Annual Review of Nutrition	2004
Acute hyperhomocysteinemia induces a reduction in arterial distensibility and compliance G Arcaro, C Fava, R Dagradi, G Faccini, S Gaino, M Degan, C Lechi, A Lechi, P Minuz	Journal of Hypertension	2004
C677T methylene-tetrahydrofolate reductase mutation in type 2 diabetic patients with and without hyperhomocysteinaemia M Buysschaert, JL Gala, A Bessomo, MP Hermans	Diabetes & Metabolism	2004
Phenotypic expression of the methylenetetrahydrofolate reductase 677C→T polymorphism and flavin cofactor availability in thyroid dysfunction S Hustad, BG Nedrebø, PM Ueland, J Schneede, SE Vollset, A Ulvik, EA Lien	The American journal of clinical nutrition	2004
Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study E Nurk, GS Tell, SE Vollset, O Nygård, H Refsum, RM Nilsen, PM Ueland	The American journal of clinical nutrition	2004
Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion H Refsum, AD Smith, PM Ueland, E Nexo, R Clarke, J McPartlin, C Johnston, F Engbaek, J Schneede, C McPartlin, JM Scott	Clinical chemistry	2004
Oxidative damage to cellular and isolated DNA by homocysteine: implications for carcinogenesis S Oikawa, K Murakami, S Kawanishi	Oncogene	2003
Atherosklerose und Urämie: Die Bedeutung nicht-traditioneller Risikofaktoren WH Hörl	Wiener klinische Wochenschrift	2003
Novel approaches to the treatment of hyperhomocysteinaemia DF Obregon, SN Murthy, DB McNamara, VA Fonseca	Expert Opinion on Therapeutic Patents	2003
Management of Hyperhomocysteinemia E Chan, VA Fonseca	Metabolic Syndrome and Related Disorders	2003
Gene-Gene and Gene-Environment Interactions in Mild Hyperhomocysteinemia A D’Angelo, G Mazzola, I Fermo	Pathophysiology of Haemostasis and Thrombosis	2003
Low Frequency of Mutated Methylenetetrahydrofolate Reductase 677 C→T and 1298 A→C Genetics Single Nucleotide Polymorphisms (SNPs) in Sub-Saharan Populations CE Adjalla, EK Amouzou, A Sanni, I Abdelmouttaleb, NW Chabi, F Namour, B Soussou, JL Guéant	Clinical Chemistry and Laboratory Medicine	2003
Methylenetetrahydrofolate reductase gene polymorphism and susceptibility to diabetic nephropathy in type 1 diabetes Y Makita, DK Moczulski, J Bochenski, AM Smiles, JH Warram, AS Krolewski	American Journal of Kidney Diseases	2003
Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia VM Shmeleva, SI Kapustin, LP Papayan, A Sobczyńska-Malefora, DJ Harrington, GF Savidge	Thrombosis Research	2003
Toxicity of nitrous oxide J Weimann	Best Practice & Research Clinical Anaesthesiology	2003
Polimorfismo C677T del gen de la metilenotetrahidrofolato reductasa en mujeres gestantes MT Escudero, G Ballesteros, J León	Progresos de Obstetricia y Ginecología	2003
Homocysteine, folic acid and B-group vitamins in obstetrics and gynaecology M la Calle, R Usandizaga, M Sancha, F Magdaleno, A Herranz, E Cabrillo	European Journal of Obstetrics & Gynecology and Reproductive Biology	2003
The Effect of Methylenetetrahydrofolate Reductase C677T Common Variant on Hypertensive Risk Is Not Solely Explained by Increased Plasma Homocysteine Values F RodríguezEsparragón, O HernándezPerera, JC RodríguezPérez, A Anabitarte, JM DíazCremades, A Losada, D Fiuza, E Hernández, C Yunis, CM Ferrario	Clinical and Experimental Hypertension	2003
Plasma thiols and their determinants in phenylketonuria C Colomé, R Artuch, C Sierra, N Brandi, N Lambruschini, J Campistol, MA Vilaseca	European Journal of Clinical Nutrition	2003
Effects of the interaction between the C677T 5,10-methylenetetrahydrofolate reductase polymorphism and serum B vitamins on homocysteine levels in pregnant women KN Kim, YJ Kim, N Chang	European Journal of Clinical Nutrition	2003
Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project R Meleady, PM Ueland, H Blom, AS Whitehead, H Refsum, LE Daly, SE Vollset, C Donohue, B Giesendorf, IM Graham, A Ulvik, Y Zhang, AL Monsen	The American journal of clinical nutrition	2003
Methylenetetrahydrofolate Reductase 677C→T Variant Modulates Folate Status Response to Controlled Folate Intakes in Young Women CL Guinotte, MG Burns, JA Axume, H Hata, TF Urrutia, A Alamilla, D McCabe, A Singgih, EA Cogger, MA Caudill	The Journal of nutrition	2003
The Effect of Folic Acid, Vitamin B6 and Vitamin B12 on the Homocysteine Levels in Rabbits Fed by Methionine-Enriched Diets F Narin, N Narin, M Akcakus, M Ustdal, I Karaküçük, C Halici	The Tohoku Journal of Experimental Medicine	2002
Reference values for serum levels of vitamin B12 and folic acid in a population-based sample of adults between 35 and 80 years of age Å Wahlin, L Bäckman, J Hultdin, R Adolfsson, LG Nilsson	Public Health Nutrition	2002
Nutritional advice to increase soluble fibre intake does not change plasma folate or homocysteine in men with angina: a randomised controlled trial PA Ashfield-Watt, ZE Clark, P Breay, PC Zotos, SB Cale, ML Burr, IF McDowell	Public Health Nutrition	2002
Effect of low doses of 5-methyltetrahydrofolate and folic acid on plasma homocysteine in healthy subjects with or without the 677CT polymorphism of methylenetetrahydrofolate reductase P Litynski, F Loehrer, L Linder, L Todesco, B Fowler	European Journal of Clinical Investigation	2002
Genetic Analysis of Vascular Factors in Alzheimer's Disease Y Wakutani, H Kowa, M Kusumi, K Yamagata, K Wada-Isoe, Y Adachi, T Takeshima, K Urakami, K Nakashima	Annals of the New York Academy of Sciences	2002
Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss H Carp, O Salomon, D Seidman, R Dardik, N Rosenberg, A Inbal	Human Reproduction	2002
Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients T Nakamura, K Saionji, Y Hiejima, H Hirayama, K Tago, H Takano, M Tajiri, K Hayashi, M Kawabata, M Funamizu, Y Makita, A Hata	American Journal of Kidney Diseases	2002
Hiperhomocistinemia y polimorfismo 677C → T de la 5,10-metilenotetrahidrofolato reductasa en hijos de pacientes con enfermedad coronaria prematura CM Cid, NG Giralt, MA Buscà, IF Codina, JF López, AM Pintó, XP Sala, DG Vaisman, SB Comas	Anales de Pediatría	2002
Association of hyperhomocysteinemia with plasma sulfate and urine sulfate excretion in patients with progressive renal disease T Nakanishi, Y Otaki, Y Hasuike, M Nanami, R Itahana, K Miyagawa, H Nishikage, M Izumi, Y Takamitsu	American Journal of Kidney Diseases	2002
Multidimensional conformational analysis of the sidechain conformers of the fully extended backbone (βL) of N-Ac-Homocysteine-NHMe; an ab initio exploratory study AR Sheraly, RV Chang, GA Chass	Journal of Molecular Structure: THEOCHEM	2002
Impact of thrombophilic gene mutations on thrombosis risk in patients with gastrointestinal carcinoma R Pihusch, G Danzl, M Scholz, D Harich, M Pihusch, P Lohse, E Hiller	Cancer	2002
Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status MC McKinley, H McNulty, J McPartlin, JJ Strain, JM Scott	European Journal of Clinical Nutrition	2002
Determinants and distributions of plasma total homocysteine concentrations among school children in Taiwan JB Chang, NF Chu, MH Shen, DM Wu, YH Liang, SM Shieh	European Journal of Epidemiology	2002
Handbook of Nutrition and Food C Lieber	Handbook of Nutrition and Food	2001
Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome H Refsum	British Journal of Nutrition	2001
Hyperhomocysteinemia and thrombosis M Cattaneo	Lipids	2001
Candidate Genes as Potential Links Between Periodontal and Cardiovascular Diseases KS Kornman, GW Duff	Annals of Periodontology	2001
Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations MR Malinow, PB Duell, MA Williams, WD Kruger, AA Evans, PH Anderson, PC Block, DL Hess, BM Upson, EE Graf, A Irvin-Jones, L Wang	Lipids	2001
Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women A Passaro	Atherosclerosis	2001
Update on selected inherited venous thrombotic disorders RS Robetorye, GM Rodgers	American Journal of Hematology	2001
The Hordaland Homocysteine Studies PM Ueland, O Nygård, SE Vollset, H Refsum	Lipids	2001
Biological and clinical implications of the MTHFR C677T polymorphism PM Ueland, S Hustad, J Schneede, H Refsum, SE Vollset	Trends in Pharmacological Sciences	2001
Hyperhomocysteinaemia and Human Reproduction WL Nelen	Clinical Chemistry and Laboratory Medicine	2001
Homocysteine and the MTHFR 677CT allele in premature coronary artery disease. Case control and family studies X Pinto, MA Vilaseca, N Garcia-Giralt, I Ferrer, M Pala, JF Meco, C Mainou, JM Ordovas, D Grinberg, S Balcells	European Journal of Clinical Investigation	2001
Quantifying the effect of folic acid NJ Wald, MR Law, JK Morris, DS Wald	The Lancet	2001
High prevalence of hyperhomocysteinemia in chronic alcoholism: the importance of the thermolabile form of the enzyme methylenetetrahydrofolate reductase (MTHFR) MJ de la Vega, F Santolaria, E González-Reimers, MR Alemán, A Milena, A Martı́nez-Riera, C González-Garcı́a	Alcohol	2001
Genetic variation of the methylenetetrahydrofolate reductase and cystathionine β-synthase genes in Korean patients with coronary artery disease and a new polymorphism in intron 7 SH Hong, J Song, JQ Kim	Molecular and Cellular Probes	2001
e Renal Vein Thrombosis, Oral Contraceptive Use, and Hyperhomocysteinemia HH Chan, JD Douketis, MJ Nowaczyk	Mayo Clinic Proceedings	2001
Acute Renal Vein Thrombosis, Oral Contraceptive Use, and Hyperhomocysteinemia HH Chan, JD Douketis, MJ Nowaczyk	Mayo Clinic Proceedings	2001
Efecto del ácido levofolínico sobre las concentraciones de homocisteína plasmática en la mujer joven y sana en la consulta preconcepcional E Fabre, M Gallo, AC Lou, G Juste, MS Romero, C Blasco, RG de Agüero, M Sobreviela, A Reyes-Engel	Medicina Clínica	2001
Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study SE Vollset, H Refsum, A Tverdal, O Nygård, JE Nordrehaug, GS Tell, PM Ueland	The American journal of clinical nutrition	2001
Population determinants of homocysteine SE Vollset, H Refsum, PM Ueland	The American journal of clinical nutrition	2001
Menorrhagia and adenomyosis in a patient with hyperhomocysteinemia, recurrent pelvic vein thromboses and extensive uterine collateral circulation treatment by supracervical hysterectomy F Nawroth, T Schmidt, D Foth, P Landwehr, T Römer	European Journal of Obstetrics & Gynecology and Reproductive Biology	2001
Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum A Ulvik, ET Evensen, EA Lien, G Hoff, SE Vollset, BM Majak, PM Ueland	American Journal of Medical Genetics	2001
Polymorphisms of Key Enzymes in Homocysteine Metabolism Affect Diet Responsiveness of Plasma Homocysteine in Healthy Women ML Silaste, M Rantala, M Sämpi, G Alfthan, A Aro, YA Kesäniemi	The Journal of nutrition	2001
Cardiovascular Genetics for Clinicians PA Doevendans, AA Wilde		2001
Correlation Between C677T MTHFR Gene Polymorphism, Plasma Homocysteine Levels and the Incidence of CAD: K Nakai, C Itoh, K Nakai, W Habano, D Gurwitz	American Journal Cardiovascular Drugs	2001
Racial variation in fasting and random homocysteine levels DA Estrada, HH Billett	American Journal of Hematology	2001
Food and Nutritional Supplements JK Ransley, JK Donnelly, NW Read		2001
Prevalence of the methylenetetrahydrofolate reductase 677C > T mutation in the Mediterranean Spanish population. Association with cardiovascular risk factors M Guillén, D Corella, O Portolés, J I González, F Mulet, C Sáiz	European Journal of Epidemiology	2001
Hyperhomocysteinemia and thrombosis M Makris	Clinical and Laboratory Haematology	2000
Nutritional aspects and possible pathological mechanisms of hyperhomocysteinaemia: an independent risk factor for vascular disease MC McKinley	Proceedings of the Nutrition Society	2000
Genetic polymorphism of 5,10-methylenetetrahydrofolate increases risk of myocardial infarction and is correlated to elevated levels of homocysteine in the Japanese general population K Nakai, T Fusazaki, T Suzuki, M Ohsawa, N Ogiu, J Kamata, K Kawazoe, K Nakai, C Itoh, M Yanagisawa, T Ishida, K Hiramori	Coronary Artery Disease	2000
Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care GL Booth, EE Wang	CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne	2000
Plasma atherogenic markers in congestive heart failure and posttransplant (heart) patients GE Cooke, GM Eaton, G Whitby, RA Kennedy, PF Binkley, ML Moeschberger, CV Leier	Journal of the American College of Cardiology	2000
Hyperhomocyst(e)inemia NS Key	Current Treatment Options in Cardiovascular Medicine	2000
The effect of 677C → T and 1298A → C mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase activity in healthy subjects A Chango, A Chango, F Boisson, F Barbé, D Quilliot, S Droesch, M Pfister, N Fillon-Emery, D Lambert, S Frémont, DS Rosenblatt, JP Nicolas	British Journal of Nutrition	2000
Methylenetetrahydrofolate reductase mutation (677C → T) negatively influences plasma homocysteine response to marginal folate intake in elderly women GP Kauwell, CE Wilsky, JJ Cerda, K Herrlinger-Garcia, AD Hutson, DW Theriaque, A Boddie, GC Rampersaud, LB Bailey	Metabolism	2000
CLINICAL AND LABORATORY FEATURES AND SEQUELAE OF DEFICIENCY OF FOLIC ACID (FOLATE) AND VITAMIN B12 (COBALAMIN) IN PREGNANCY AND GYNECOLOGY EP Frenkel, DA Yardley	Hematology/Oncology Clinics of North America	2000
Reducción de concentraciones elevadas de homocisteína con ácido fólico y vitaminas B en pacientes con tromboembolia venosa: relación entre respuesta y genotipo C677T de la metilén tetrahidrofólico reductasa (MTHFR) ÁJ Ordóñez, JM Rodríguez, CR Álvarez, JS García, JM Carreira, MV Martínez, EC García	Medicina Clínica	2000
Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism S Hustad, PM Ueland, SE Vollset, Y Zhang, AL Bjørke-Monsen, J Schneede	Clinical chemistry	2000
The controversy over homocysteine and cardiovascular risk PM Ueland, H Refsum, SA Beresford, SE Vollset	The American journal of clinical nutrition	2000
Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study SE Vollset, H Refsum, LM Irgens, BM Emblem, A Tverdal, HK Gjessing, AL Monsen, PM Ueland	The American journal of clinical nutrition	2000
Homocysteine levels during fasting and after methionine loading in adolescents with diabetic retinopathy and nephropathy F Chiarelli, M Pomilio, A Mohn, S Tumini, M Vanelli, G Morgese, A Spagnoli, A Verrotti	The Journal of Pediatrics	2000
METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISMS IN PREECLAMPSIA AND THE HELLP SYNDROME PL Zusterzeel, W Visser, HJ Bolm, WH Peters, SG Heil, EA Steegers, EA Steegers	Hypertension in Pregnancy	2000
Homocysteine as a Risk Factor for Atherosclerosis ME Temple, AB Luzier, DJ Kazierad	The Annals of pharmacotherapy	2000
Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children EE Delvin, R Rozen, A Merouani, J Genest, M Lambert	The American journal of clinical nutrition	2000
Methylenetetrahydrofolate Reductase 677 C → T Mutation and Coronary Heart Disease Risk in UK Indian Asians JC Chambers, H Ireland, E Thompson, P Reilly, OA Obeid, H Refsum, P Ueland, DA Lane, JS Kooner	Arteriosclerosis, thrombosis, and vascular biology	2000
Homocysteine and Vascular Disease K Robinson		2000
Total homocysteine and cardiovascular disease O Nygard, SE Vollset, H Refsum, L Brattstrom, PM Ueland	Journal of Internal Medicine	1999
Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss WH Kutteh, VM Park, SR Deitcher	Fertility and Sterility	1999
Thrombophilia-associated pregnancy wastage Z Blumenfeld, B Brenner	Fertility and Sterility	1999
Current international literature citation–nutrition GK Grimble	Nutrition	1999
Factor V Leiden and other hypercoagulable state mutations are not associated with osteonecrosis during or after treatment for pediatric malignancy AM Kechli, JA Wilimas, CH Pui, VM Park, S Tonkel, SR Deitcher	The Journal of Pediatrics	1999
The C677T Methylenetetrahydrofolate Reductase Polymorphism Influences the Homocysteine-Lowering Effect of Hormone Replacement Therapy CA Brown, KQ McKinney, KB Young, HJ Norton	Molecular Genetics and Metabolism	1999
Homocyst(e)ine and Cardiovascular Disease: A Critical Review of the Epidemiologic Evidence JW Eikelboom, E Lonn, J Genest, G Hankey, S Yusuf	Annals of internal medicine	1999
Metabolic markers of vitamin nutritional status JB Ubbink	The American journal of clinical nutrition	1999
Plasma Total Homocyst(e)ine May Not Be the Most Appropriate Index for Cardiovascular Disease Risk EB Stamm, RD Reynolds	The Journal of nutrition	1999
Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial IA Brouwer, M van Dusseldorp, CM Thomas, M Duran, JG Hautvast, TK Eskes, RP Steegers-Theunissen	The American journal of clinical nutrition	1999
Reply to PB Duell and MR Malinow JV Woodside, IS Young, JW Yarnell, D McMaster, CC Patterson, EE McCrum, A Evans, KF Gey, DL Harmon, AS Whitehead	The American journal of clinical nutrition	1999
Plasma homocysteine concentrations in a Belgian school-age population CD Laet, JC Wautrecht, D Brasseur, M Dramaix, JM Boeynaems, J Decuyper, A Kahn	The American journal of clinical nutrition	1999
Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population RZ Stolzenberg-Solomon, ER Miller, MG Maguire, J Selhub, LJ Appel	The American journal of clinical nutrition	1999
Homocyst(e)ine, Diet, and Cardiovascular Diseases: A Statement for Healthcare Professionals From the Nutrition Committee, American Heart Association MR Malinow, AG Bostom, RM Krauss	Circulation	1999
Determinants of Fasting and Post-Methionine Homocysteine Levels in Families Predisposed to Hyperhomocysteinemia and Premature Vascular Disease SC de Jong, CD Stehouwer, M van den Berg, PJ Kostense, D Alders, C Jakobs, G Pals, JA Rauwerda	Arteriosclerosis, thrombosis, and vascular biology	1999
Inherited Prothrombotic Conditions and Premature Ischemic Stroke: Sex Difference in the Association With Factor V Leiden M Margaglione, G DAndrea, N Giuliani, V Brancaccio, DD Lucia, E Grandone, VD Stefano, PA Tonali, GD Minno	Arteriosclerosis, thrombosis, and vascular biology	1999
Recent data are not in conflict with homocysteine as a cardiovascular risk factor H Refsum, PM Ueland	Current Opinion in Lipidology	1998
C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations V Gudnason, D Stansbie, J Scott, A Bowron, V Nicaud, S Humphries	Atherosclerosis	1998
Homocysteine as a risk factor for cardiovascular and related disease: nutritional implications DG Weir, JM Scott	Nutrition Research Reviews	1998
HOMOCYSTEINE AND CARDIOVASCULAR DISEASE HR MD, PM MD, ON MD, SE Dr.PH	Annual Review of Medicine	1998
Isoelectrofocusing Phenotype and Relative Concentration of Transcobalamin II Isoproteins Related to the Codon 259 Arg/Pro Polymorphism F Namour, M Guy, I Aimone-Gastin, M Nonancourt, N Mrabet, JL Guéant	Biochemical and Biophysical Research Communications	1998
Additional genetic risk factors for venous thromboembolismin carriers of the factor V Leiden mutation A Tosetto, F Rodeghiero, I Martinelli, VD Stefano, E Missiaglia, P Chiusolo, PM Mannucci	British Journal of Haematology	1998
A common methylenetetrahydrofolate reductase gene mutation and longevity L Brattström, Y Zhang, M Hurtig, H Refsum, S Östensson, L Fransson, K Jonés, F Landgren, L Brudin, PM Ueland	Atherosclerosis	1998
LABORATORY EVALUATION OF HYPERCOAGULABLE STATES EM van Cott, M Laposata	Hematology/Oncology Clinics of North America	1998
Reduction of Plasma Homocyst(e)ine Levels by Breakfast Cereal Fortified with Folic Acid in Patients with Coronary Heart Disease MR Malinow, PB Duell, DL Hess, PH Anderson, WD Kruger, BE Phillipson, RA Gluckman, PC Block, BM Upson	New England Journal of Medicine	1998
The C677T mutation in the methylenetetrahydrofolate reductase gene predisposes to hyperhomocysteinemia in children with familial hypercholesterolemia treated with cholestyramine S Tonstad, H Refsum, L Ose, PM Ueland	The Journal of Pediatrics	1998
Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults MF Bellamy, IF McDowell, MW Ramsey, M Brownlee, C Bones, RG Newcombe, MJ Lewis	Circulation	1998
Methylenetetrahydrofolate Reductase Polymorphism Affects the Change in Homocysteine and Folate Concentrations Resulting from Low Dose Folic Acid Supplementation in Women with Unexplained Recurrent Miscarriages WL Nelen, HJ Blom, CM Thomas, EA Steegers, GH Boers, TK Eskes	The Journal of nutrition	1998
Methylenetetrahydrofolate Reductase Gene Polymorphism and Ischemic Stroke in Japanese H Morita, H Kurihara, S Tsubaki, T Sugiyama, C Hamada, Y Kurihara, T Shindo, Y Oh-hashi, K Kitamura, Y Yazaki	Arteriosclerosis, thrombosis, and vascular biology	1998
Common Methylenetetrahydrofolate Reductase Gene Mutation Leads to Hyperhomocysteinemia but Not to Vascular Disease: The Result of a Meta-Analysis L Brattström, DE Wilcken, J Öhrvik, L Brudin	Circulation	1998
Preventing Coronary Heart Disease: B Vitamins and Homocysteine GS Omenn, SA Beresford, AG Motulsky	Circulation	1998
Methylenetetrahydrofolate Reductase C677T Mutation, Plasma Homocysteine, and Folate in Subjects From Northern Italy With or Without Angiographically Documented Severe Coronary Atherosclerotic Disease: Evidence for an Important Genetic-Environmental Interaction D Girelli, S Friso, E Trabetti, O Olivieri, C Russo, R Pessotto, G Faccini, PF Pignatti, A Mazzucco, R Corrocher	Blood	1998
Effective Treatment of Cobalamin Deficiency With Oral Cobalamin AM Kuzminski, EJ Giacco, RH Allen, SP Stabler, J Lindenbaum	Blood	1998
Kinetics of Plasma Total Homocysteine in Patients Receiving High-Dose Methotrexate Therapy AB Guttormsen, PM Ueland, PE Lønning, O Mella, H Refsum	Clinical chemistry	1998
Variability and determinants of total homocysteine concentrations in plasma in an elderly population R Clarke, P Woodhouse, A Ulvik, C Frost, P Sherliker, H Refsum, PM Ueland, KT Khaw	Clinical chemistry	1998
Simultaneous determination of methylenetetrahydrofolate reductase C677T and factor V G1691A genotypes by mutagenically separated PCR and multiple-injection capillary electrophoresis A Ulvik, J Ren, H Refsum, PM Ueland	Clinical chemistry	1998
Should All Elderly People Receive Folate Supplements?: JB Ubbink	Drugs & Aging	1998
Hyperhomocysteinemia: A risk factor for arterial and venous thrombotic disease M Cattaneo	International Journal of Clinical & Laboratory Research	1997
HOMOCYSTEINE AND VASCULAR DYSFUNCTION SR Lentz	Life Sciences	1997
Recommendations on folate intake R Whitehead, C Bates	The Lancet	1997
Approaches to defining the optimal dietary folate intake for cardiovascular health IF McDowell, P Ashfield-Watt	Nutrition & Food Science	1997
Les nouvelles causes de thrombophilie constitutionnelle I Quéré, J Emmerich	La Revue de Médecine Interne	1997
Association Between Plasma Total Homocysteine and Parental History of Cardiovascular Disease in Children With Familial Hypercholesterolemia S Tonstad, H Refsum, PM Ueland	Circulation	1997
Assessment of homocysteine status H Refsum, T Fiskerstrand, AB Guttormsen, PM Ueland	Journal of Inherited Metabolic Disease	1997
Multiple Risk Factors in Cardiovascular Disease AM Gotto, C Lenfant, AL Catapano, R Paoletti		1995
Replacement of Renal Function by Dialysis W Drukker, FM Parsons, JF Maher		1979

Advertisement