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Citations to this article

Corticotropin-releasing hormone excites adrenocorticotropin-secreting human pituitary adenoma cells by activating a nonselective cation current.
K Takano, … , A Teramoto, T Fujita
K Takano, … , A Teramoto, T Fujita
Published November 1, 1996
Citation Information: J Clin Invest. 1996;98(9):2033-2041. https://doi.org/10.1172/JCI119008.
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Research Article

Corticotropin-releasing hormone excites adrenocorticotropin-secreting human pituitary adenoma cells by activating a nonselective cation current.

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Abstract

The mechanisms of corticotropin-releasing hormone (CRH) induced excitation of ACTH-secreting adenoma cells were investigated using the perforated whole-cell clamp technique and intracellular Ca2+ concentration ([Ca2+]i) measurement. CRH depolarized ACTH-secreting adenoma cells by activating a nonselective cation current that showed slight inward rectification. This channel did not seem to be a member of the Ca(2+)-activated cation currents because it was activated even when the [Ca2+]i was chelated below 50 nM. The activation of the current was induced by protein kinase A-mediated pathways. By [Ca2+]i measurement, CRH increased [Ca2+]i of these cells dependently on voltage-gated Ca2+ current. This CRH-induced [Ca2+]i increase was abolished in Na(+)-free extracellular solution, but was not abolished by the addition of 5 microM tetrodotoxin to the extracellular solution. CRH-induced ACTH secretion from the cultured adenoma cells was also abolished in Na(+)-free extracellular solution, but not in tetrodotoxin-containing extracellular solution. These data indicate that a Na+ current (maybe the nonselective cation current) other than voltage-gated Na+ current plays an important role in CRH-induced [Ca2+]i increase and ACTH secretion. CRH also activated a nonselective cation current in nonadenoma human corticotrophs, suggesting that the activation of a nonselective cation current is a physiological mechanism of CRH-induced excitation in human corticotrophs.

Authors

K Takano, J Yasufuku-Takano, A Teramoto, T Fujita

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Total citations by year

Year: 2021 2019 2018 2017 2015 2014 2013 2011 2005 2004 2002 2000 1998 1997 Total
Citations: 1 1 1 1 1 1 1 1 3 1 1 1 1 1 16
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Citations to this article (16)

Title and authors Publication Year
Diverse intracellular signaling pathways mediate the effects of neurotensin on the excitability of type II neurons in the rat dorsolateral bed nucleus of the stria terminalis
T Kaneko, R Hara, T Amano, M Minami
Journal of Pharmacological Sciences 2021
Temporally Tuned Corticosteroid Feedback Regulation of the Stress Axis
JS Kim, KJ Iremonger
Trends in endocrinology and metabolism: TEM 2019
Corticotropin releasing hormone can selectively stimulate glucose uptake in corticotropinoma via glucose transporter 1
J Lu, BK Montgomery, GP Chatain, A Bugarini, Q Zhang, X Wang, NA Edwards, A Ray-Chaudhury, MJ Merrill, RR Lonser, P Chittiboina
Molecular and Cellular Endocrinology 2018
Modeling the diversity of spontaneous and agonist-induced electrical activity in anterior pituitary corticotrophs
PA Fletcher, H Zemkova, SS Stojilkovic, A Sherman
Journal of neurophysiology 2017
Large conductance Ca 2+ -activated K + (BK) channels promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs: BK channels promote secretagogue-induced bursting in corticotrophs
PJ Duncan, S Şengül, J Tabak, P Ruth, R Bertram, MJ Shipston
The Journal of Physiology 2015
Utility of hCRH-stimulated (18) F-FDG PET-CT scan in localisation of pituitary microadenoma in Cushing's disease: CRH-stimulated (18) F-FDG PET-CT scan
HP Patt, V Lele, A Lila, T Bandgar, N Shah
Journal of Medical Imaging and Radiation Oncology 2014
Opposing Roles of Corticotropin-Releasing Factor and Neuropeptide Y within the Dorsolateral Bed Nucleus of the Stria Terminalis in the Negative Affective Component of Pain in Rats
S Ide, T Hara, A Ohno, R Tamano, K Koseki, T Naka, C Maruyama, K Kaneda, M Yoshioka, M Minami
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Control of hypothalamic-pituitary-adrenal stress axis activity by the intermediate conductance calcium-activated potassium channel, SK4: Stress hyperresponsiveness in Kcnn4 −/− mice
Z Liang, L Chen, H McClafferty, R Lukowski, D MacGregor, JT King, S Rizzi, M Sausbier, DP McCobb, HG Knaus, P Ruth, MJ Shipston
The Journal of Physiology 2011
PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis
S Seino, T Shibasaki
Physiological reviews 2005
Mechanisms of TRH-induced GH Release (Paradoxical Response) in Human Somatotroph Adenoma Cells
H OKINAGA, K TAKANO, S HAYASHI, J YASUFUKU-TAKANO, A TERAMOTO, T FUJITA
Endocrine Journal 2005
Mechanism of Adrenomedullin-induced Prolactin Release from Human Prolactin-releasing Adenoma Cells
N KIMATA-HAYASHI, K TAKANO, J YASUFUKU-TAKANO, A TERAMOTO, T FUJITA
Endocrine Journal 2005
Nuclear Factor of Activated T Cells (NFAT) Is Involved in the Depolarization-Induced Activation of Growth Hormone-Releasing Hormone Gene Transcription in Vitro
M Asai, Y Iwasaki, M Yoshida, N Mutsuga-Nakayama, H Arima, M Ito, K Takano, Y Oiso
Molecular Endocrinology 2004
Regulatory role of glucocorticoids and glucocorticoid receptor mRNA levels on tyrosine hydroxylase gene expression in the locus coeruleus during repeated immobilization stress
S Makino, MA Smith, PW Gold
Brain Research 2002
CRH-induced Electrical Activity and Calcium Signalling in Pituitary Corticotrophs
PR Shorten, A Robson, AE Mckinnon, DJ Wall
Journal of Theoretical Biology 2000
Differential regulation of MAP kinase activity by corticotropin-releasing hormone in normal and neoplastic corticotropes
H Li, PJ Robinson, S Kawashima, JW Funder, JP Liu
The International Journal of Biochemistry & Cell Biology 1998
Stimulation of Ca 2+ influx in αT3–1 gonadotrophs via the cAMP/PKA signaling system
M Hezareh, W Schlegel, SR Rawlings
American journal of physiology. Endocrinology and metabolism 1997

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