Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.
W K Jones, … , W A Ng, J Robbins
W K Jones, … , W A Ng, J Robbins
Published October 15, 1996
Citation Information: J Clin Invest. 1996;98(8):1906-1917. https://doi.org/10.1172/JCI118992.
View: Text | PDF
Research Article Article has an altmetric score of 6

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.

  • Text
  • PDF
Abstract

The alpha-myosin heavy chain (alpha-MyHC) is the major contractile protein expressed in the myocardium of adult mice. We have produced mice carrying a null mutation of alpha-MyHC by homologous recombination in murine ES cells. Homozygous null animals die between 11 and 12 d in utero of gross heart defects, while alpha-MyHC+/- heterozygotes survive and appear externally normal. The presence of a single functional alpha-MyHC+ allele in heterozygous animals results in reduced levels of the transcript and protein as well as fibrosis and alterations in sarcomeric structure. Examination of heart function using a working heart preparation revealed severe impairment of both contractility and relaxation in a subset of the alpha-MyHC+/- animals. Thus, two alpha-MyHC+ alleles are necessary for normal cardiac development, and hemizygosity for the normal allele can result in altered cardiac function.

Authors

W K Jones, I L Grupp, T Doetschman, G Grupp, H Osinska, T E Hewett, G Boivin, J Gulick, W A Ng, J Robbins

×

Total citations by year

Year: 2025 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1992 1991 1978 Total
Citations: 1 5 3 5 3 3 2 2 2 3 3 3 5 7 5 6 6 6 1 4 4 4 9 18 20 12 17 6 1 1 2 169
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (169)

Title and authors Publication Year
Experimental Models of Hypertrophic Cardiomyopathy: A Systematic Review
van den Dolder FW, Dinani R, Warnaar VA, Vučković S, Passadouro AS, Nassar AA, Ramsaroep AX, Burchell GB, Schoonmade LJ, van der Velden J, Goversen B
JACC: Basic to Translational Science 2025
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice
Reichart D, Newby GA, Wakimoto H, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JD, Kohli S, Chmatal L, Page DC, Zabaleta N, Vandenberghe L, Liu DR, Seidman JG, Seidman C
Nature Medicine 2023
Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development.
DeMoya RA, Forman-Rubinsky RE, Fontaine D Jr, Shin J, Watkins SC, Lo CW, Tsang M
Frontiers in Cell and Developmental Biology 2023
Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation.
Hau HA, Kelu JJ, Ochala J, Hughes SM
Developmental Biology 2023
Sin3a Associated Protein 130kDa, sap130, plays an evolutionary conserved role in zebrafish heart development.
DeMoya RA, Forman-Rubinsky RE, Fontaine D Jr, Shin J, Watkins SC, Lo C, Tsang M
bioRxiv : the preprint server for biology 2023
Exploring the complex spectrum of dominance and recessiveness in genetic cardiomyopathies
Lipov A, Jurgens SJ, Mazzarotto F, Allouba M, Pirruccello JP, Aguib Y, Gennarelli M, Yacoub MH, Ellinor PT, Bezzina CR, Walsh R
2023
The Oxidative Balance Orchestrates the Main Keystones of the Functional Activity of Cardiomyocytes
M Bevere, C Morabito, M Mariggiò, S Guarnieri, D Giustarini
Oxidative Medicine & Cellular Longevity 2022
Sinus node dysfunction: current understanding and future directions
Manoj P, Kim JA, Kim S, Li T, Sewani M, Chelu MG, Li N
American journal of physiology. Heart and circulatory physiology 2022
Visualizing Subcellular Localization of a Protein in the Heart using Quantum Dots-Mediated Immuno-Labeling Followed By Transmission Electron Microscopy
Aishwarya R, Abdullah CS, Remex NS, Nitu S, Hartman B, King J, Bhuiyan MS
Journal of visualized experiments : JoVE 2022
Genetic Etiology of Left‐Sided Obstructive Heart Lesions: A Story in Development
LE Parker, AP Landstrom
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2021
Adipose Lipolysis Regulates Cardiac Glucose Uptake and Function in Mice under Cold Stress
Y Choi, H Shin, Z Tang, Y Yeh, Y Ma, AK Kadegowda, H Wang, L Jiang, RK Arya, L Chen, B Xue, H Shi, O Gavrilova, L Yu
International journal of molecular sciences 2021
A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes
A Matos-Nieves, S Manivannan, U Majumdar, KL McBride, P White, V Garg
Frontiers in Cardiovascular Medicine 2021
Biologically Derived, Three-Dimensional, Embryonic Scaffolds for Long-Term Cardiomyocyte Culture
MG Garry, S Kren, JB Wenger, DJ Garry
Stem Cells and Development 2021
Contraction–relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium
F Fazlollahi, JJ Gonzalez, SJ Repas, BD Canan, GE Billman, PM Janssen
The Journal of General Physiology 2021
Gene therapy for inherited arrhythmias
VJ Bezzerides, M Prondzynski, L Carrier, WT Pu
Cardiovascular Research 2020
Genetics of Transposition of Great Arteries: Between Laterality Abnormality and Outflow Tract Defect
MD Ita, B Cisneros, H Rosas-Vargas
Journal of Cardiovascular Translational Research 2020
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides
BR Anderson, ML Jensen, PH Hagedorn, SC Little, RE Olson, R Ammar, B Kienzle, J Thompson, I McDonald, S Mercer, J Vikesaa, B Nordbo, L Iben, Y Cao, J Natale, G Dalton-Kay, A Cacace, BR Hansen, Hedtjärn, T Koch, LJ Bristow
Molecular Therapy — Nucleic Acids 2020
In utero exposure to diesel exhaust is associated with alterations in neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation
JM Goodson, JW MacDonald, TK Bammler, WM Chien, MT Chin
Particle and Fibre Toxicology 2019
Endothelial cell modulation of cardiomyocyte gene expression
F Jiang, F Mohr, ND Ullrich, M Hecker, AH Wagner
Experimental Cell Research 2019
Defective sarcomere organization and reduced larval locomotion and fish survival in slow muscle heavy chain 1 ( smyhc1 ) mutants
S Li, H Wen, S Du
The FASEB Journal 2019
Insertional Mutagenesis Confounds the Mechanism of the Morbid Phenotype of a PLN R9C Transgenic Mouse Line
A Kraev
Journal of Cardiac Failure 2018
Modeling the Transition From Decompensated to Pathological Hypertrophy
F Pascual, JC Schisler, TJ Grevengoed, MS Willis, RA Coleman
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2018
Molecular mechanisms of cardioprotective effects mediated by transplanted cardiac ckit+ cells through the activation of an inflammatory hypoxia-dependent reparative response
G Puddighinu, D D'Amario, E Foglio, M Manchi, A Siracusano, E Pontemezzo, M Cordella, F Facchiano, L Pellegrini, A Mangoni, M Tafani, F Crea, A Germani, MA Russo, F Limana
Oncotarget 2017
Oliver Smithies, DPhil: 1925–2017
J Robbins
Circulation research 2017
Cardiac cytoarchitecture — why the “hardware” is important for heart function!
E Ehler
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2016
Healing a Heart Through Genetic Intervention
J James, J Robbins
Circulation research 2016
Proteomic Profiling of Early Chronic Pulmonary Hypertension: Evidence for Both Adaptive and Maladaptive Pathology
AA M
Journal of Pulmonary & Respiratory Medicine 2015
A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction
J Yan, L Zhang, N Sultana, DS Park, A Shekhar, L Bu, J Hu, S Razzaque, CL Cai, GC Fan
PloS one 2015
A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9
KJ Carroll, CA Makarewich, J McAnally, DM Anderson, L Zentilin, N Liu, M Giacca, R Bassel-Duby, EN Olson
Proceedings of the National Academy of Sciences 2015
The functional diversity of essential genes required for mammalian cardiac development: Cardiac Essential Genes
C Clowes, MG Boylan, LA Ridge, E Barnes, JA Wright, KE Hentges
genesis 2014
Direct and indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension
A Liu, D Schreier, L Tian, JC Eickhoff, Z Wang, TA Hacker, NC Chesler
American journal of physiology. Heart and circulatory physiology 2014
Determination of Residual Feed Intake and Its Associations with Single Nucleotide Polymorphism in Chickens
Z XU, J CHEN, Y ZHANG, C JI, D ZHANG, X ZHANG
Journal of Integrative Agriculture 2014
Genetics of congenital heart disease: the glass half empty
AC Fahed, BD Gelb, JG Seidman, CE Seidman
Circulation research 2013
Allele-Specific Silencing of Mutant Myh6 Transcripts in Mice Suppresses Hypertrophic Cardiomyopathy
J Jiang, H Wakimoto, JG Seidman, CE Seidman
Science 2013
Glucocorticoid receptor is required for foetal heart maturation
EA Rog-Zielinska, A Thomson, CJ Kenyon, DG Brownstein, CM Moran, D Szumska, Z Michailidou, J Richardson, E Owen, A Watt, H Morrison, LM Forrester, S Bhattacharya, MC Holmes, KE Chapman
Human Molecular Genetics 2013
Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development
D Chen, S Li, R Singh, S Spinette, R Sedlmeier, HF Epstein
Journal of cell science 2012
Heavy and light roles: myosin in the morphogenesis of the heart
J England, S Loughna
Cellular and Molecular Life Sciences 2012
Molecular biological analysis of cardiac effect of high temperature in rats
Y Nakagawa, H Inoue, K Shinone, M Ikemura, M Nata
Legal Medicine 2012
Cardiac myosin binding protein-C: redefining its structure and function
S Sadayappan, PP de Tombe
Biophysical Reviews 2012
Physical exercise reduces cardiac defects in type 2 spinal muscular atrophy-like mice: Physical exercise reduces cardiac defects in spinal muscular atrophy
O Biondi, P Lopes, C Desseille, J Branchu, F Chali, AB Salah, C Pariset, C Chanoine, F Charbonnier
The Journal of Physiology 2012
The Mef2A Transcription Factor Coordinately Regulates a Costamere Gene Program in Cardiac Muscle*
EP Ewen, CM Snyder, M Wilson, D Desjardins, FJ Naya
The Journal of biological chemistry 2011
Heme Oxygenase-1 Induction Enhances Cell Survival and Restores Contractility to Unvascularized Three-Dimensional Adult Cardiomyocyte Grafts Implanted In Vivo
S Kawamoto, JP Flynn, Q Shi, SW Sakr, J Luo, MD Allen
Tissue Engineering Part A 2011
Genome-wide differential gene expression in immortalized DF-1 chicken embryo fibroblast cell line
BW Kong, JY Lee, WG Bottje, K Lassiter, J Lee, DN Foster
BMC Genomics 2011
Cardiac-Specific NRAP Overexpression Causes Right Ventricular Dysfunction in Mice
S Lu, GL Crawford, J Dore, SA Anderson, D Despres, R Horowits
Experimental Cell Research 2011
Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity
V Mishra, P Ghumatkar, MV Patel, S Devada, R Ranvir, P Swain, R Sundar, R Bahekar, MR Jain
International Journal of Endocrinology 2011
The Mef2A Transcription Factor Coordinately Regulates a Costamere Gene Program in Cardiac Muscle
EP Ewen, CM Snyder, M Wilson, D Desjardins, FJ Naya
The Journal of biological chemistry 2011
Gene expression in breast muscle associated with feed efficiency in a single male broiler line using a chicken 44K oligo microarray. I. Top differentially expressed genes
BW Kong, JJ Song, JY Lee, BM Hargis, T Wing, K Lassiter, W Bottje
Poultry science 2011
Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats
K Wenzel, G Wallukat, F Qadri, N Hubner, H Schulz, O Hummel, F Herse, A Heuser, R Fischer, H Heidecke, FC Luft, DN Muller, R Dietz, R Dechend
PloS one 2010
Lymphocyte responses exacerbate angiotensin II-dependent hypertension
SD Crowley, YS Song, EE Lin, R Griffiths, HS Kim, P Ruiz
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2010
Effect of U50,488H, a κ-opioid receptor agonist on myocardial α-and β-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced cardiac hypertrophy in rat
A Jaiswal, S Kumar, S Seth, AK Dinda, SK Maulik
Molecular and Cellular Biochemistry 2010
Genetic factors in non-syndromic congenital heart malformations
MW Wessels, PJ Willems
Clinical Genetics 2010
Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats
A Jaiswal, S Kumar, R Enjamoori, S Seth, AK Dinda, SK Maulik
European Journal of Pharmacology 2010
Role of Animal Models in HCM Research
R Shephard, C Semsarian
Journal of Cardiovascular Translational Research 2009
Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice
MP Massett, R Fan, BC Berk
Physiological genomics 2009
Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development
M Maitra, MK Schluterman, HA Nichols, JA Richardson, CW Lo, D Srivastava, V Garg
Developmental Biology 2009
Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6
A Abu-Daya, AK Sater, DE Wells, TJ Mohun, LB Zimmerman
Developmental Biology 2009
Differential translocation of nuclear factor-kappaB in a cardiac muscle cell line under gravitational changes
O Kwon, M Tranter, WK Jones, JM Sankovic, RK Banerjee
Journal of Biomechanical Engineering 2009
Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice
MP Massett, R Fan, BC Berk
Physiological genomics 2009
A Novel Complex Within the Cardiomyocyte Sarcomere is Critical For Biomechanical Stress Responses in Hypertrophy
Farah Sheikh(1), Anna Raskin(1,2), Pao-Hsien Chu(3), Stephan Lange(1), Andrea A. Domenighetti(1), Ming Zheng(1), Xingqun Liang(1), Tong Zhang(4), ToshitakaYajima(1), Yusu Gu(1), Nancy D. Dalton(1), Sushil K. Mahata(1,5), Gerald W. Dorn II(6), Joan Heller-Brown(4), Kirk L. Peterson(1), Jeff H. Omens(1,2), Andrew D. McCulloch(1,2), Ju Chen(1)
Journal of Clinical Investigation 2008
Cell biology of embryonic migration
S Kurosaka, A Kashina
Birth defects research. Part C, Embryo today : reviews 2008
Protein Science Encyclopedia
G Schmitz, T Langmann
Protein Science Encyclopedia 2008
Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
S Lowey, LM Lesko, AS Rovner, AR Hodges, SL White, RB Low, M Rincon, J Gulick, J Robbins
The Journal of biological chemistry 2008
Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death
M Zheng, H Cheng, X Li, J Zhang, L Cui, K Ouyang, L Han, T Zhao, Y Gu, ND Dalton, ML Bang, KL Peterson, J Chen
Human Molecular Genetics 2008
Functional Effects of the Hypertrophic Cardiomyopathy R403Q Mutation Are Different in an α- or β-Myosin Heavy Chain Backbone
S Lowey, LM Lesko, AS Rovner, AR Hodges, SL White, RB Low, M Rincon, J Gulick, J Robbins
The Journal of biological chemistry 2008
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
E van Rooij, LB Sutherland, X Qi, JA Richardson, J Hill, EN Olson
Science 2007
A small RNA makes a Bic difference
HF Moffett, CD Novina
Genome biology 2007
Post-Genomic Cardiology
J Marín-García, MJ Goldenthal, GW Moe
Post-Genomic Cardiology 2007
eNOS deficient mice develop progressive cardiac hypertrophy with altered cytokine and calcium handling protein expression
MP Flaherty, M Brown, IL Grupp, JE Schultz, SS Murphree, WK Jones
Cardiovascular Toxicology 2007
Distribution and Structure-Function Relationship of Myosin Heavy Chain Isoforms in the Adult Mouse Heart
M Krenz, S Sadayappan, HE Osinska, JA Henry, S Beck, DM Warshaw, J Robbins
The Journal of biological chemistry 2007
Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development
Y Wang, D Szczesna-Cordary, R Craig, Z Diaz-Perez, G Guzman, T Miller, JD Potter
The FASEB Journal 2007
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
SD Crowley, SB Gurley, MJ Herrera, P Ruiz, R Griffiths, AP Kumar, HS Kim, O Smithies, TH Le, TM Coffman
Proceedings of the National Academy of Sciences 2006
Loaded wheel running and muscle adaptation in the mouse
JP Konhilas
American journal of physiology. Heart and circulatory physiology 2005
The Essential Light Chain N-terminal Extension Alters Force and Fiber Kinetics in Mouse Cardiac Muscle
MS Miller, BM Palmer, S Ruch, LA Martin, GP Farman, Y Wang, J Robbins, TC Irving, DW Maughan
The Journal of biological chemistry 2005
Cardiac-specific blockade of NF-κB in cardiac pathophysiology: differences between acute and chronic stimuli in vivo
M Brown, M McGuinness, T Wright, X Ren, Y Wang, GP Boivin, H Hahn, AM Feldman, WK Jones
American journal of physiology. Heart and circulatory physiology 2005
Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function
S Sadayappan, J Gulick, H Osinska, LA Martin, HS Hahn, GW Dorn, R Klevitsky, CE Seidman, JG Seidman, J Robbins
Circulation research 2005
Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved
L Wei, GE Taffet, DS Khoury, J Bo, Y Li, A Yatani, MC Delaughter, R Klevitsky, TE Hewett, J Robbins, LH Michael, MD Schneider, ML Entman, RJ Schwartz
The FASEB Journal 2004
Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex
HH Li, V Kedar, C Zhang, H McDonough, R Arya, DZ Wang, C Patterson
Journal of Clinical Investigation 2004
Impact of beta-myosin heavy chain expression on cardiac function during stress
M Krenz, J Robbins
Journal of the American College of Cardiology 2004
Transgenesis and cardiac energetics: new insights into cardiac metabolism
JS Ingwall
Journal of Molecular and Cellular Cardiology 2004
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
Julian C. Braz, Orlando F. Bueno, Qiangrong Liang, Benjamin J. Wilkins, Yan-Shan Dai, Stephanie Parsons, Joseph Braunwart, Betty J. Glascock, Raisa Klevitsky, Thomas F. Kimball, Timothy E. Hewett, and Jeffery D. Molkentin
Journal of Clinical Investigation 2003
Single-stranded DNA-binding Proteins PURα and PURβ Bind to a Purine-rich Negative Regulatory Element of the α-Myosin Heavy Chain Gene and Control Transcriptional and Translational Regulation of the Gene Expression: IMPLICATIONS IN THE REPRESSION OF α-MYOSIN HEAVY CHAIN DURING HEART FAILURE
M Gupta, V Sueblinvong, J Raman, V Jeevanandam, MP Gupta
The Journal of biological chemistry 2003
Cocaine Produces Cardiac Hypertrophy by Protein Kinase C Dependent Mechanisms
RJ Henning, Y Li
Journal of cardiovascular pharmacology and therapeutics 2003
Electrophysiological phenotyping in genetically engineered mice
CI Berul
Physiological genomics 2003
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth
BJ Wilkins, LJ de Windt, OF Bueno, JC Braz, BJ Glascock, TF Kimball, JD Molkentin
Molecular and cellular biology 2002
Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice
OF Bueno, BJ Wilkins, KM Tymitz, BJ Glascock, TF Kimball, JN Lorenz, JD Molkentin
Proceedings of the National Academy of Sciences 2002
STRIATEDMUSCLECYTOARCHITECTURE: An Intricate Web of Form and Function
KA Clark, AS McElhinny, MC Beckerle, CC Gregorio
Annual Review of Cell and Developmental Biology 2002
Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor?
JD Molkentin, JR Lu, CL Antos, B Markham, J Richardson, J Robbins, SR Grant, EN Olson
Circulation 2002
Coordinate changes in Myosin heavy chain isoform gene expression are selectively associated with alterations in dilated cardiomyopathy phenotype
WT Abraham, EM Gilbert, BD Lowes, WA Minobe, P Larrabee, RL Roden, D Dutcher, J Sederberg, JA Lindenfeld, EE Wolfel, SF Shakar, D Ferguson, K Volkman, JV Linseman, RA Quaife, AD Robertson, MR Bristow
Molecular Medicine 2002
Protein Kinase C ε Signaling Complexes Include Metabolism- and Transcription/Translation-related Proteins: Complimentary Separation Techniques With LC/MS/MS
RD Edmondson, TM Vondriska, KJ Biederman, J Zhang, RC Jones, Y Zheng, DL Allen, JX Xiu, EM Cardwell, MR Pisano, P Ping
Molecular & cellular proteomics : MCP 2002
Gene Dosage-Dependent Effects of Cardiac-Specific Overexpression of the A 3 Adenosine Receptor
RG Black, Y Guo, ZD Ge, SS Murphree, SD Prabhu, WK Jones, R Bolli, JA Auchampach
Circulation research 2002
Vertebrate Myogenesis
B Brand-Saberi
2002
Ischemic Protection and Myofibrillar Cardiomyopathy: Dose-Dependent Effects of In Vivo δPKC Inhibition
HS Hahn, MG Yussman, T Toyokawa, Y Marreez, TJ Barrett, KC Hilty, H Osinska, J Robbins, GW Dorn
Circulation research 2002
Manipulations of cardiac adrenergic signaling and calcium cycling have markedly different effects on the progression of cardiomyopathy
Kalev Freeman, Imanuel Lerman, Evangelia G. Kranias, Teresa Bohlmeyer, Michael R. Bristow, Robert J. Lefkowitz, Guido Iaccarino, Walter J. Koch, Leslie A. Leinwand
Journal of Clinical Investigation 2001
Myocardial Regeneration
S Etzion, LH Kedes, RA Kloner, J Leor
American Journal of Cardiovascular Drugs 2001
The molecular genetic basis for hypertrophic cardiomyopathy
AJ Marian, R Roberts
Journal of Molecular and Cellular Cardiology 2001
Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy
RL Nicol, N Frey, G Pearson, M Cobb, J Richardson, EN Olson
The EMBO Journal 2001
Molecular genetics and pathogenesis of hypertrophic cardiomyopathy
AJ Marian, L Salek, S Lutucuta
Minerva medica 2001
Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction
Y Okamoto, A Chaves, J Chen, R Kelley, K Jones, HG Weed, KL Gardner, L Gangi, M Yamaguchi, W Klomkleaw, T Nakayama, RL Hamlin, C Carnes, R Altschuld, J Bauer, T Hai
The American Journal of Pathology 2001
Heart Physiology and Pathophysiology
NS Dhalla, RM Temsah, T Netticadan, MS Sandhu
Heart Physiology and Pathophysiology 2001
Modelos animales genéticamente modificados en investigación cardiovascular
F Dalloz, H Osinska, J Robbins
Revista Española de Cardiología 2001
Manipulating the Contractile Apparatus: Genetically Defined Animal Models of Cardiovascular Disease
F Dalloz, H Osinska, J Robbins
Journal of Molecular and Cellular Cardiology 2001
Phenotypic Deficits in Mice Expressing a Myosin Binding Protein C Lacking the Titin and Myosin Binding Domains
Q Yang, H Osinska, R Klevitsky, J Robbins
Journal of Molecular and Cellular Cardiology 2001
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene
K Freeman, C Colon-Rivera, MC Olsson, RL Moore, HD Weinberger, IL Grupp, KL Vikstrom, G Iaccarino, WJ Koch, LA Leinwand
American journal of physiology. Heart and circulatory physiology 2001
Enhanced PKCβII translocation and PKCβII-RACK1 interactions in PKCε-induced heart failure: a role for RACK1
JM Pass, J Gao, WK Jones, WB Wead, X Wu, J Zhang, CP Baines, R Bolli, YT Zheng, IG Joshua, P Ping
American journal of physiology. Heart and circulatory physiology 2001
Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy
BJ Aronow, T Toyokawa, A Canning, K Haghighi, U Delling, E Kranias, JD Molkentin, GW Dorn
Physiological genomics 2001
Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy
DL Allen, BC Harrison, C Sartorius, WC Byrnes, LA Leinwand
American journal of physiology. Cell physiology 2001
Mouse Model of Desmin-Related Cardiomyopathy
X Wang, H Osinska, GW Dorn, M Nieman, JN Lorenz, AM Gerdes, S Witt, T Kimball, J Gulick, J Robbins
Circulation 2001
Increased Myocardial Rab GTPase Expression: A Consequence and Cause of Cardiomyopathy
G Wu, MG Yussman, TJ Barrett, HS Hahn, H Osinska, GM Hilliard, X Wang, T Toyokawa, A Yatani, RA Lynch, J Robbins, GW Dorn
Circulation research 2001
The Dual-Specificity Phosphatase MKP-1 Limits the Cardiac Hypertrophic Response In Vitro and In Vivo
OF Bueno, LJ Windt, HW Lim, KM Tymitz, SA Witt, TR Kimball, JD Molkentin
Circulation research 2001
Formation of the Heart and Its Regulation
RJ Tomanek, RB Runyan
2001
Cardiac Electrophysiology in Genetically Engineered Mice
J Gehrmann, CI Berul
Journal of Cardiovascular Electrophysiology 2000
Cardiac Dysfunction Occurs in the HIV-1 Transgenic Mouse Treated with Zidovudine
W Lewis, IL Grupp, G Grupp, B Hoit, R Morris, AM Samarel, L Bruggeman, P Klotman
Laboratory Investigation 2000
Inactivation of myosin heavy chain genes in the mouse: Diverse and unexpected phenotypes
DL Allen, BC Harrison, LA Leinwand
Microscopy Research and Technique 2000
Animal models of hypertrophic cardiomyopathy
A Maass, LA Leinwand
Current Opinion in Cardiology 2000
Remodeling the Cardiac Sarcomere Using Transgenesis
J Robbins
Annual Review of Physiology 2000
Protein kinase-A dependent phosphorylation of transcription enhancer factor-1 represses its DNA-binding activity but enhances its gene activation ability
MP Gupta, P Kogut, M Gupta
Nucleic Acids Research 2000
Serotonin 2B receptor is required for heart development
CG Nebigil, DS Choi, A Dierich, P Hickel, ML Meur, N Messaddeq, JM Launay, L Maroteaux
Proceedings of the National Academy of Sciences 2000
To the heart of myofibril assembly
CC Gregorio, PB Antin
Trends in Cell Biology 2000
Early Onset Heart Failure in Transgenic Mice with Dilated Cardiomyopathy
DG Hall, GE Morley, D Vaidya, M Ard, TR Kimball, SA Witt, MC Colbert
Pediatric Research 2000
Decreased left ventricular ejection fraction in transgenic mice expressing mutant cardiac troponin T-Q(92), responsible for human hypertrophic cardiomyopathy
DS Lim, L Oberst, M McCluggage, K Youker, J Lacy, F DeMayo, ML Entman, R Roberts, LH Michael, AJ Marian
Journal of Molecular and Cellular Cardiology 2000
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction
DD D'Angelo, Y Sakata, JN Lorenz, GP Boivin, RA Walsh, SB Liggett, GW 2nd
Molecular pharmacology 2000
Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects
JC Tardiff, TE Hewett, SM Factor, KL Vikstrom, J Robbins, LA Leinwand
American journal of physiology. Heart and circulatory physiology 2000
Cardiac-specific Overexpression of a Superinhibitory Pentameric Phospholamban Mutant Enhances Inhibition of Cardiac Function in Vivo
J Zhai, AG Schmidt, BD Hoit, Y Kimura, DH MacLennan, EG Kranias
The Journal of biological chemistry 2000
Identification and Genomic Cloning of CMHC1: A UNIQUE MYOSIN HEAVY CHAIN EXPRESSED EXCLUSIVELY IN THE DEVELOPING CHICKEN HEART
JD Croissant, S Carpenter, D Bader
The Journal of biological chemistry 2000
Transgenic Modeling of a Cardiac Troponin I Mutation Linked to Familial Hypertrophic Cardiomyopathy
J James, Y Zhang, H Osinska, A Sanbe, R Klevitsky, TE Hewett, J Robbins
Circulation research 2000
Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy
HW Lim, LJ Windt, L Steinberg, T Taigen, SA Witt, TR Kimball, JD Molkentin
Circulation 2000
Chronic Elevation of Calmodulin in the Ventricles of Transgenic Mice Increases the Autonomous Activity of Calmodulin-Dependent Protein Kinase II, Which Regulates Atrial Natriuretic Factor Gene Expression
JM Colomer, AR Means
Molecular Endocrinology 2000
Transgenic Mouse Model of Stunned Myocardium
AM Murphy, H Kögler, D Georgakopoulos, JL McDonough, DA Kass, JE Eyk, E Marbán
Science 2000
Elastic Filaments of the Cell
HL Granzier, GH Pollack
2000
Dexamethasone induced cardiac hypertrophy in newborn rats is accompanied by changes in myosin heavy chain phenotype and gene transcription
S Muangmingsuk, P Ingram, M P Gupta, R A Arcilla, M Gupta
Molecular and Cellular Biochemistry 2000
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure
VP Sah, S Minamisawa, SP Tam, TH Wu, GW 2nd, J Ross, KR Chien, JH Brown
Journal of Clinical Investigation 1999
Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice
BK McConnell, KA Jones, D Fatkin, LH Arroyo, RT Lee, O Aristizabal, DH Turnbull, D Georgakopoulos, D Kass, M Bond, H Niimura, FJ Schoen, D Conner, DA Fischman, CE Seidman, JG Seidman, DH Fischman
Journal of Clinical Investigation 1999
MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium
SM Kolodziejczyk, L Wang, K Balazsi, Y DeRepentigny, R Kothary, LA Megeney
Current Biology 1999
Heart Development
GF Wang, FE Stockdale
Heart Development 1999
Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse
NM Tepe, SB Liggett
FEBS Letters 1999
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy
S Minamisawa, M Hoshijima, G Chu, CA Ward, K Frank, Y Gu, ME Martone, Y Wang, J Ross, EG Kranias, WR Giles, KR Chien
Cell 1999
Ischemic Preconditioning Increases iNOS Transcript Levels in Conscious Rabbits via a Nitric Oxide-dependent Mechanism
WK Jones, MP Flaherty, XL Tang, H Takano, Y Qiu, S Banerjee, T Smith, R Bolli
Journal of Molecular and Cellular Cardiology 1999
Abnormal Cardiac Structure and Function in Mice Expressing Nonphosphorylatable Cardiac Regulatory Myosin Light Chain 2
A Sanbe, JG Fewell, J Gulick, H Osinska, J Lorenz, DG Hall, LA Murray, TR Kimball, SA Witt, J Robbins
The Journal of biological chemistry 1999
Cardiac-specific Overexpression of the α 1 Subunit of the L-type Voltage-dependent Ca 2+ Channel in Transgenic Mice: LOSS OF ISOPROTERENOL-INDUCED CONTRACTION
JN Muth, H Yamaguchi, G Mikala, IL Grupp, W Lewis, H Cheng, LS Song, EG Lakatta, G Varadi, A Schwartz
The Journal of biological chemistry 1999
Cardiac Specific Overexpression of Transglutaminase II (G h ) Results in a Unique Hypertrophy Phenotype Independent of Phospholipase C Activation
K Small, JF Feng, J Lorenz, ET Donnelly, A Yu, MJ Im, GW Dorn, SB Liggett
The Journal of biological chemistry 1999
A Post-transcriptional Compensatory Pathway in Heterozygous Ventricular Myosin Light Chain 2-Deficient Mice Results in Lack of Gene Dosage Effect during Normal Cardiac Growth or Hypertrophy
S Minamisawa, Y Gu, J Ross, KR Chien, J Chen
The Journal of biological chemistry 1999
Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology
J James, H Osinska, T E Hewett, T Kimball, R Klevitsky, S Witt, D G Hall, J Gulick, J Robbins
Transgenic Research 1999
Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice
MA Sussman, S Welch, N Cambon, R Klevitsky, TE Hewett, R Price, SA Witt, TR Kimball
Journal of Clinical Investigation 1998
Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice
JG Fewell, TE Hewett, A Sanbe, R Klevitsky, E Hayes, D Warshaw, D Maughan, J Robbins
Journal of Clinical Investigation 1998
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
Q Yang, A Sanbe, H Osinska, TE Hewett, R Klevitsky, J Robbins
Journal of Clinical Investigation 1998
Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice
L Oberst, G Zhao, JT Park, R Brugada, LH Michael, ML Entman, R Roberts, AJ Marian
Journal of Clinical Investigation 1998
Why does the myocardium fail? Insights from basic science
MR Bristow
The Lancet 1998
Molecular Genetic Basis of Hypertrophic Cardiomyopathy:
AJ Marian, R Roberts
Journal of Cardiovascular Electrophysiology 1998
Genetically engineered mice: Model systems for left ventricular failure
VJ Kadambi, EG Kranias
Journal of Cardiac Failure 1998
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
Q Yang, A Sanbe, H Osinska, TE Hewett, R Klevitsky, J Robbins
Journal of Clinical Investigation 1998
Vertebrate homologs oftinman andbagpipe: Roles of the homeobox genes in cardiovascular development
M Tanaka, H Kasahara, S Bartunkova, M Schinke, I Komuro, H Inagaki, Y Lee, GE Lyons, S Izumo
Developmental Genetics 1998
Cardiac transgenic and gene-targeted mice as models of cardiac hypertrophy and failure: A problem of (new) riches
S Izumo, T Shioi
Journal of Cardiac Failure 1998
Cardiomyocytes and non-muscle cells in cardiac hypertrophy: a molecular perspective
M Gupta, MP Gupta, RA Arcilla, R Zak
Progress in Pediatric Cardiology 1998
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Jeffery D. Molkentin, Jian-Rong Lu, Christopher L. Antos, Bruce Markham, James Richardson, Jeffrey Robbins, Stephen R. Grant, Eric N. Olson
Cell 1998
Familial Hypertrophic Cardiomyopathy: From Mutations to Functional Defects
G Bonne, L Carrier, P Richard, B Hainque, K Schwartz
Circulation research 1998
Cardiac Physiology in Transgenic Mice
JF James, TE Hewett, J Robbins
Circulation research 1998
α-Tropomyosin Knockouts: A Blow Against Transcriptional Chauvinism
J Robbins
Circulation research 1998
Molecular and Physiological Effects of α-Tropomyosin Ablation in the Mouse
P Rethinasamy, M Muthuchamy, T Hewett, G Boivin, BM Wolska, C Evans, RJ Solaro, DF Wieczorek
Circulation research 1998
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.
Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN
Cell 1998
Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice
MC Colbert, DG Hall, TR Kimball, SA Witt, JN Lorenz, ML Kirby, TE Hewett, R Klevitsky, J Robbins
Journal of Clinical Investigation 1997
Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium
BD Lowes, W Minobe, WT Abraham, MN Rizeq, TJ Bohlmeyer, RA Quaife, RL Roden, DL Dutcher, AD Robertson, NF Voelkel, DB Badesch, BM Groves, EM Gilbert, MR Bristow
Journal of Clinical Investigation 1997
Molecular remodeling of cardiac contractile function
J James, J Robbins
American journal of physiology. Heart and circulatory physiology 1997
Targeted Ablation of the Murine α-Tropomyosin Gene
EM Blanchard, K Iizuka, M Christe, DA Conner, A Geisterfer-Lowrance, FJ Schoen, DW Maughan, CE Seidman, JG Seidman
Circulation research 1997
Manipulating Myosin Light Chain 2 Isoforms In Vivo: A Transgenic Approach to Understanding Contractile Protein Diversity
R Kelly, M Buckingham
Circulation research 1997
Fashioning the vertebrate heart: earliest embryonic decisions
MC Fishman, KR Chien
Development (Cambridge, England) 1997
Left Ventricular Hypertrophy
WS Aronow
Journal of the American Geriatrics Society 1992
International Review of Cytology
RA Miller
International Review of Cytology 1991
Time constant of isovolumic pressure fall: determinants in the working left ventricle
OF Bueno, LJ de Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, TE Hewett, SP Jones, DJ Lefer, CF Peng, RN Kitsis, JD Molkentin
The American journal of physiology 1978
Time constant of isovolumic pressure fall: determinants in the working left ventricle
OF Bueno, LJ de Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, TE Hewett, SP Jones, DJ Lefer, CF Peng, RN Kitsis, JD Molkentin
The American journal of physiology 1978

← Previous 1 2 3 … 6 7 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 8 patents
57 readers on Mendeley
See more details