The alpha-myosin heavy chain (alpha-MyHC) is the major contractile protein expressed in the myocardium of adult mice. We have produced mice carrying a null mutation of alpha-MyHC by homologous recombination in murine ES cells. Homozygous null animals die between 11 and 12 d in utero of gross heart defects, while alpha-MyHC+/- heterozygotes survive and appear externally normal. The presence of a single functional alpha-MyHC+ allele in heterozygous animals results in reduced levels of the transcript and protein as well as fibrosis and alterations in sarcomeric structure. Examination of heart function using a working heart preparation revealed severe impairment of both contractility and relaxation in a subset of the alpha-MyHC+/- animals. Thus, two alpha-MyHC+ alleles are necessary for normal cardiac development, and hemizygosity for the normal allele can result in altered cardiac function.
W K Jones, I L Grupp, T Doetschman, G Grupp, H Osinska, T E Hewett, G Boivin, J Gulick, W A Ng, J Robbins
Title and authors | Publication | Year |
---|---|---|
Experimental Models of Hypertrophic Cardiomyopathy: A Systematic Review
van den Dolder FW, Dinani R, Warnaar VA, Vučković S, Passadouro AS, Nassar AA, Ramsaroep AX, Burchell GB, Schoonmade LJ, van der Velden J, Goversen B |
JACC: Basic to Translational Science | 2025 |
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice
Reichart D, Newby GA, Wakimoto H, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JD, Kohli S, Chmatal L, Page DC, Zabaleta N, Vandenberghe L, Liu DR, Seidman JG, Seidman C |
Nature Medicine | 2023 |
Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development.
DeMoya RA, Forman-Rubinsky RE, Fontaine D Jr, Shin J, Watkins SC, Lo CW, Tsang M |
Frontiers in Cell and Developmental Biology | 2023 |
Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation.
Hau HA, Kelu JJ, Ochala J, Hughes SM |
Developmental Biology | 2023 |
Sin3a Associated Protein 130kDa, sap130, plays an evolutionary conserved role in zebrafish heart development.
DeMoya RA, Forman-Rubinsky RE, Fontaine D Jr, Shin J, Watkins SC, Lo C, Tsang M |
bioRxiv : the preprint server for biology | 2023 |
Exploring the complex spectrum of dominance and recessiveness in genetic cardiomyopathies
Lipov A, Jurgens SJ, Mazzarotto F, Allouba M, Pirruccello JP, Aguib Y, Gennarelli M, Yacoub MH, Ellinor PT, Bezzina CR, Walsh R |
2023 | |
The Oxidative Balance Orchestrates the Main Keystones of the Functional Activity of Cardiomyocytes
M Bevere, C Morabito, M Mariggiò, S Guarnieri, D Giustarini |
Oxidative Medicine & Cellular Longevity | 2022 |
Sinus node dysfunction: current understanding and future directions
Manoj P, Kim JA, Kim S, Li T, Sewani M, Chelu MG, Li N |
American journal of physiology. Heart and circulatory physiology | 2022 |
Visualizing Subcellular Localization of a Protein in the Heart using Quantum Dots-Mediated Immuno-Labeling Followed By Transmission Electron Microscopy
Aishwarya R, Abdullah CS, Remex NS, Nitu S, Hartman B, King J, Bhuiyan MS |
Journal of visualized experiments : JoVE | 2022 |
Genetic Etiology of Left‐Sided Obstructive Heart Lesions: A Story in Development
LE Parker, AP Landstrom |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2021 |
Adipose Lipolysis Regulates Cardiac Glucose Uptake and Function in Mice under Cold Stress
Y Choi, H Shin, Z Tang, Y Yeh, Y Ma, AK Kadegowda, H Wang, L Jiang, RK Arya, L Chen, B Xue, H Shi, O Gavrilova, L Yu |
International journal of molecular sciences | 2021 |
A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes
A Matos-Nieves, S Manivannan, U Majumdar, KL McBride, P White, V Garg |
Frontiers in Cardiovascular Medicine | 2021 |
Biologically Derived, Three-Dimensional, Embryonic Scaffolds for Long-Term Cardiomyocyte Culture
MG Garry, S Kren, JB Wenger, DJ Garry |
Stem Cells and Development | 2021 |
Contraction–relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium
F Fazlollahi, JJ Gonzalez, SJ Repas, BD Canan, GE Billman, PM Janssen |
The Journal of General Physiology | 2021 |
Gene therapy for inherited arrhythmias
VJ Bezzerides, M Prondzynski, L Carrier, WT Pu |
Cardiovascular Research | 2020 |
Genetics of Transposition of Great Arteries: Between Laterality Abnormality and Outflow Tract Defect
MD Ita, B Cisneros, H Rosas-Vargas |
Journal of Cardiovascular Translational Research | 2020 |
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides
BR Anderson, ML Jensen, PH Hagedorn, SC Little, RE Olson, R Ammar, B Kienzle, J Thompson, I McDonald, S Mercer, J Vikesaa, B Nordbo, L Iben, Y Cao, J Natale, G Dalton-Kay, A Cacace, BR Hansen, Hedtjärn, T Koch, LJ Bristow |
Molecular Therapy — Nucleic Acids | 2020 |
In utero exposure to diesel exhaust is associated with alterations in neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation
JM Goodson, JW MacDonald, TK Bammler, WM Chien, MT Chin |
Particle and Fibre Toxicology | 2019 |
Endothelial cell modulation of cardiomyocyte gene expression
F Jiang, F Mohr, ND Ullrich, M Hecker, AH Wagner |
Experimental Cell Research | 2019 |
Defective sarcomere organization and reduced larval locomotion and fish survival in slow muscle heavy chain 1 ( smyhc1 ) mutants
S Li, H Wen, S Du |
The FASEB Journal | 2019 |
Insertional Mutagenesis Confounds the Mechanism of the Morbid Phenotype of a PLN R9C Transgenic Mouse Line
A Kraev |
Journal of Cardiac Failure | 2018 |
Modeling the Transition From Decompensated to Pathological Hypertrophy
F Pascual, JC Schisler, TJ Grevengoed, MS Willis, RA Coleman |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2018 |
Molecular mechanisms of cardioprotective effects mediated by transplanted cardiac ckit+ cells through the activation of an inflammatory hypoxia-dependent reparative response
G Puddighinu, D D'Amario, E Foglio, M Manchi, A Siracusano, E Pontemezzo, M Cordella, F Facchiano, L Pellegrini, A Mangoni, M Tafani, F Crea, A Germani, MA Russo, F Limana |
Oncotarget | 2017 |
Oliver Smithies, DPhil: 1925–2017
J Robbins |
Circulation research | 2017 |
Cardiac cytoarchitecture — why the “hardware” is important for heart function!
E Ehler |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2016 |
Healing a Heart Through Genetic Intervention
J James, J Robbins |
Circulation research | 2016 |
Proteomic Profiling of Early Chronic Pulmonary Hypertension: Evidence for Both Adaptive and Maladaptive Pathology
AA M |
Journal of Pulmonary & Respiratory Medicine | 2015 |
A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction
J Yan, L Zhang, N Sultana, DS Park, A Shekhar, L Bu, J Hu, S Razzaque, CL Cai, GC Fan |
PloS one | 2015 |
A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9
KJ Carroll, CA Makarewich, J McAnally, DM Anderson, L Zentilin, N Liu, M Giacca, R Bassel-Duby, EN Olson |
Proceedings of the National Academy of Sciences | 2015 |
The functional diversity of essential genes required for mammalian cardiac development: Cardiac Essential Genes
C Clowes, MG Boylan, LA Ridge, E Barnes, JA Wright, KE Hentges |
genesis | 2014 |
Direct and indirect protection of right ventricular function by estrogen in an experimental model of pulmonary arterial hypertension
A Liu, D Schreier, L Tian, JC Eickhoff, Z Wang, TA Hacker, NC Chesler |
American journal of physiology. Heart and circulatory physiology | 2014 |
Determination of Residual Feed Intake and Its Associations with Single Nucleotide Polymorphism in Chickens
Z XU, J CHEN, Y ZHANG, C JI, D ZHANG, X ZHANG |
Journal of Integrative Agriculture | 2014 |
Genetics of congenital heart disease: the glass half empty
AC Fahed, BD Gelb, JG Seidman, CE Seidman |
Circulation research | 2013 |
Allele-Specific Silencing of Mutant Myh6 Transcripts in Mice Suppresses Hypertrophic Cardiomyopathy
J Jiang, H Wakimoto, JG Seidman, CE Seidman |
Science | 2013 |
Glucocorticoid receptor is required for foetal heart maturation
EA Rog-Zielinska, A Thomson, CJ Kenyon, DG Brownstein, CM Moran, D Szumska, Z Michailidou, J Richardson, E Owen, A Watt, H Morrison, LM Forrester, S Bhattacharya, MC Holmes, KE Chapman |
Human Molecular Genetics | 2013 |
Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development
D Chen, S Li, R Singh, S Spinette, R Sedlmeier, HF Epstein |
Journal of cell science | 2012 |
Heavy and light roles: myosin in the morphogenesis of the heart
J England, S Loughna |
Cellular and Molecular Life Sciences | 2012 |
Molecular biological analysis of cardiac effect of high temperature in rats
Y Nakagawa, H Inoue, K Shinone, M Ikemura, M Nata |
Legal Medicine | 2012 |
Cardiac myosin binding protein-C: redefining its structure and function
S Sadayappan, PP de Tombe |
Biophysical Reviews | 2012 |
Physical exercise reduces cardiac defects in type 2 spinal muscular atrophy-like mice: Physical exercise reduces cardiac defects in spinal muscular atrophy
O Biondi, P Lopes, C Desseille, J Branchu, F Chali, AB Salah, C Pariset, C Chanoine, F Charbonnier |
The Journal of Physiology | 2012 |
The Mef2A Transcription Factor Coordinately Regulates a Costamere Gene Program in Cardiac Muscle*
EP Ewen, CM Snyder, M Wilson, D Desjardins, FJ Naya |
The Journal of biological chemistry | 2011 |
Heme Oxygenase-1 Induction Enhances Cell Survival and Restores Contractility to Unvascularized Three-Dimensional Adult Cardiomyocyte Grafts Implanted In Vivo
S Kawamoto, JP Flynn, Q Shi, SW Sakr, J Luo, MD Allen |
Tissue Engineering Part A | 2011 |
Genome-wide differential gene expression in immortalized DF-1 chicken embryo fibroblast cell line
BW Kong, JY Lee, WG Bottje, K Lassiter, J Lee, DN Foster |
BMC Genomics | 2011 |
Cardiac-Specific NRAP Overexpression Causes Right Ventricular Dysfunction in Mice
S Lu, GL Crawford, J Dore, SA Anderson, D Despres, R Horowits |
Experimental Cell Research | 2011 |
Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity
V Mishra, P Ghumatkar, MV Patel, S Devada, R Ranvir, P Swain, R Sundar, R Bahekar, MR Jain |
International Journal of Endocrinology | 2011 |
The Mef2A Transcription Factor Coordinately Regulates a Costamere Gene Program in Cardiac Muscle
EP Ewen, CM Snyder, M Wilson, D Desjardins, FJ Naya |
The Journal of biological chemistry | 2011 |
Gene expression in breast muscle associated with feed efficiency in a single male broiler line using a chicken 44K oligo microarray. I. Top differentially expressed genes
BW Kong, JJ Song, JY Lee, BM Hargis, T Wing, K Lassiter, W Bottje |
Poultry science | 2011 |
Alpha1A-adrenergic receptor-directed autoimmunity induces left ventricular damage and diastolic dysfunction in rats
K Wenzel, G Wallukat, F Qadri, N Hubner, H Schulz, O Hummel, F Herse, A Heuser, R Fischer, H Heidecke, FC Luft, DN Muller, R Dietz, R Dechend |
PloS one | 2010 |
Lymphocyte responses exacerbate angiotensin II-dependent hypertension
SD Crowley, YS Song, EE Lin, R Griffiths, HS Kim, P Ruiz |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2010 |
Effect of U50,488H, a κ-opioid receptor agonist on myocardial α-and β-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced cardiac hypertrophy in rat
A Jaiswal, S Kumar, S Seth, AK Dinda, SK Maulik |
Molecular and Cellular Biochemistry | 2010 |
Genetic factors in non-syndromic congenital heart malformations
MW Wessels, PJ Willems |
Clinical Genetics | 2010 |
Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats
A Jaiswal, S Kumar, R Enjamoori, S Seth, AK Dinda, SK Maulik |
European Journal of Pharmacology | 2010 |
Role of Animal Models in HCM Research
R Shephard, C Semsarian |
Journal of Cardiovascular Translational Research | 2009 |
Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice
MP Massett, R Fan, BC Berk |
Physiological genomics | 2009 |
Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development
M Maitra, MK Schluterman, HA Nichols, JA Richardson, CW Lo, D Srivastava, V Garg |
Developmental Biology | 2009 |
Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6
A Abu-Daya, AK Sater, DE Wells, TJ Mohun, LB Zimmerman |
Developmental Biology | 2009 |
Differential translocation of nuclear factor-kappaB in a cardiac muscle cell line under gravitational changes
O Kwon, M Tranter, WK Jones, JM Sankovic, RK Banerjee |
Journal of Biomechanical Engineering | 2009 |
Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice
MP Massett, R Fan, BC Berk |
Physiological genomics | 2009 |
A Novel Complex Within the Cardiomyocyte Sarcomere is Critical For Biomechanical Stress Responses in Hypertrophy
Farah Sheikh(1), Anna Raskin(1,2), Pao-Hsien Chu(3), Stephan Lange(1), Andrea A. Domenighetti(1), Ming Zheng(1), Xingqun Liang(1), Tong Zhang(4), ToshitakaYajima(1), Yusu Gu(1), Nancy D. Dalton(1), Sushil K. Mahata(1,5), Gerald W. Dorn II(6), Joan Heller-Brown(4), Kirk L. Peterson(1), Jeff H. Omens(1,2), Andrew D. McCulloch(1,2), Ju Chen(1) |
Journal of Clinical Investigation | 2008 |
Cell biology of embryonic migration
S Kurosaka, A Kashina |
Birth defects research. Part C, Embryo today : reviews | 2008 |
Protein Science Encyclopedia
G Schmitz, T Langmann |
Protein Science Encyclopedia | 2008 |
Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
S Lowey, LM Lesko, AS Rovner, AR Hodges, SL White, RB Low, M Rincon, J Gulick, J Robbins |
The Journal of biological chemistry | 2008 |
Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death
M Zheng, H Cheng, X Li, J Zhang, L Cui, K Ouyang, L Han, T Zhao, Y Gu, ND Dalton, ML Bang, KL Peterson, J Chen |
Human Molecular Genetics | 2008 |
Functional Effects of the Hypertrophic Cardiomyopathy R403Q Mutation Are Different in an α- or β-Myosin Heavy Chain Backbone
S Lowey, LM Lesko, AS Rovner, AR Hodges, SL White, RB Low, M Rincon, J Gulick, J Robbins |
The Journal of biological chemistry | 2008 |
Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA
E van Rooij, LB Sutherland, X Qi, JA Richardson, J Hill, EN Olson |
Science | 2007 |
A small RNA makes a Bic difference
HF Moffett, CD Novina |
Genome biology | 2007 |
Post-Genomic Cardiology
J Marín-García, MJ Goldenthal, GW Moe |
Post-Genomic Cardiology | 2007 |
eNOS deficient mice develop progressive cardiac hypertrophy with altered cytokine and calcium handling protein expression
MP Flaherty, M Brown, IL Grupp, JE Schultz, SS Murphree, WK Jones |
Cardiovascular Toxicology | 2007 |
Distribution and Structure-Function Relationship of Myosin Heavy Chain Isoforms in the Adult Mouse Heart
M Krenz, S Sadayappan, HE Osinska, JA Henry, S Beck, DM Warshaw, J Robbins |
The Journal of biological chemistry | 2007 |
Fast skeletal muscle regulatory light chain is required for fast and slow skeletal muscle development
Y Wang, D Szczesna-Cordary, R Craig, Z Diaz-Perez, G Guzman, T Miller, JD Potter |
The FASEB Journal | 2007 |
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
SD Crowley, SB Gurley, MJ Herrera, P Ruiz, R Griffiths, AP Kumar, HS Kim, O Smithies, TH Le, TM Coffman |
Proceedings of the National Academy of Sciences | 2006 |
Loaded wheel running and muscle adaptation in the mouse
JP Konhilas |
American journal of physiology. Heart and circulatory physiology | 2005 |
The Essential Light Chain N-terminal Extension Alters Force and Fiber Kinetics in Mouse Cardiac Muscle
MS Miller, BM Palmer, S Ruch, LA Martin, GP Farman, Y Wang, J Robbins, TC Irving, DW Maughan |
The Journal of biological chemistry | 2005 |
Cardiac-specific blockade of NF-κB in cardiac pathophysiology: differences between acute and chronic stimuli in vivo
M Brown, M McGuinness, T Wright, X Ren, Y Wang, GP Boivin, H Hahn, AM Feldman, WK Jones |
American journal of physiology. Heart and circulatory physiology | 2005 |
Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function
S Sadayappan, J Gulick, H Osinska, LA Martin, HS Hahn, GW Dorn, R Klevitsky, CE Seidman, JG Seidman, J Robbins |
Circulation research | 2005 |
Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved
L Wei, GE Taffet, DS Khoury, J Bo, Y Li, A Yatani, MC Delaughter, R Klevitsky, TE Hewett, J Robbins, LH Michael, MD Schneider, ML Entman, RJ Schwartz |
The FASEB Journal | 2004 |
Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex
HH Li, V Kedar, C Zhang, H McDonough, R Arya, DZ Wang, C Patterson |
Journal of Clinical Investigation | 2004 |
Impact of beta-myosin heavy chain expression on cardiac function during stress
M Krenz, J Robbins |
Journal of the American College of Cardiology | 2004 |
Transgenesis and cardiac energetics: new insights into cardiac metabolism
JS Ingwall |
Journal of Molecular and Cellular Cardiology | 2004 |
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
Julian C. Braz, Orlando F. Bueno, Qiangrong Liang, Benjamin J. Wilkins, Yan-Shan Dai, Stephanie Parsons, Joseph Braunwart, Betty J. Glascock, Raisa Klevitsky, Thomas F. Kimball, Timothy E. Hewett, and Jeffery D. Molkentin |
Journal of Clinical Investigation | 2003 |
Single-stranded DNA-binding Proteins PURα and PURβ Bind to a Purine-rich Negative Regulatory Element of the α-Myosin Heavy Chain Gene and Control Transcriptional and Translational Regulation of the Gene Expression: IMPLICATIONS IN THE REPRESSION OF α-MYOSIN HEAVY CHAIN DURING HEART FAILURE
M Gupta, V Sueblinvong, J Raman, V Jeevanandam, MP Gupta |
The Journal of biological chemistry | 2003 |
Cocaine Produces Cardiac Hypertrophy by Protein Kinase C Dependent Mechanisms
RJ Henning, Y Li |
Journal of cardiovascular pharmacology and therapeutics | 2003 |
Electrophysiological phenotyping in genetically engineered mice
CI Berul |
Physiological genomics | 2003 |
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth
BJ Wilkins, LJ de Windt, OF Bueno, JC Braz, BJ Glascock, TF Kimball, JD Molkentin |
Molecular and cellular biology | 2002 |
Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice
OF Bueno, BJ Wilkins, KM Tymitz, BJ Glascock, TF Kimball, JN Lorenz, JD Molkentin |
Proceedings of the National Academy of Sciences | 2002 |
STRIATEDMUSCLECYTOARCHITECTURE: An Intricate Web of Form and Function
KA Clark, AS McElhinny, MC Beckerle, CC Gregorio |
Annual Review of Cell and Developmental Biology | 2002 |
Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor?
JD Molkentin, JR Lu, CL Antos, B Markham, J Richardson, J Robbins, SR Grant, EN Olson |
Circulation | 2002 |
Coordinate changes in Myosin heavy chain isoform gene expression are selectively associated with alterations in dilated cardiomyopathy phenotype
WT Abraham, EM Gilbert, BD Lowes, WA Minobe, P Larrabee, RL Roden, D Dutcher, J Sederberg, JA Lindenfeld, EE Wolfel, SF Shakar, D Ferguson, K Volkman, JV Linseman, RA Quaife, AD Robertson, MR Bristow |
Molecular Medicine | 2002 |
Protein Kinase C ε Signaling Complexes Include Metabolism- and Transcription/Translation-related Proteins: Complimentary Separation Techniques With LC/MS/MS
RD Edmondson, TM Vondriska, KJ Biederman, J Zhang, RC Jones, Y Zheng, DL Allen, JX Xiu, EM Cardwell, MR Pisano, P Ping |
Molecular & cellular proteomics : MCP | 2002 |
Gene Dosage-Dependent Effects of Cardiac-Specific Overexpression of the A 3 Adenosine Receptor
RG Black, Y Guo, ZD Ge, SS Murphree, SD Prabhu, WK Jones, R Bolli, JA Auchampach |
Circulation research | 2002 |
Vertebrate Myogenesis
B Brand-Saberi |
2002 | |
Ischemic Protection and Myofibrillar Cardiomyopathy: Dose-Dependent Effects of In Vivo δPKC Inhibition
HS Hahn, MG Yussman, T Toyokawa, Y Marreez, TJ Barrett, KC Hilty, H Osinska, J Robbins, GW Dorn |
Circulation research | 2002 |
Manipulations of cardiac adrenergic signaling and calcium cycling have markedly different effects on the progression of cardiomyopathy
Kalev Freeman, Imanuel Lerman, Evangelia G. Kranias, Teresa Bohlmeyer, Michael R. Bristow, Robert J. Lefkowitz, Guido Iaccarino, Walter J. Koch, Leslie A. Leinwand |
Journal of Clinical Investigation | 2001 |
Myocardial Regeneration
S Etzion, LH Kedes, RA Kloner, J Leor |
American Journal of Cardiovascular Drugs | 2001 |
The molecular genetic basis for hypertrophic cardiomyopathy
AJ Marian, R Roberts |
Journal of Molecular and Cellular Cardiology | 2001 |
Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy
RL Nicol, N Frey, G Pearson, M Cobb, J Richardson, EN Olson |
The EMBO Journal | 2001 |
Molecular genetics and pathogenesis of hypertrophic cardiomyopathy
AJ Marian, L Salek, S Lutucuta |
Minerva medica | 2001 |
Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction
Y Okamoto, A Chaves, J Chen, R Kelley, K Jones, HG Weed, KL Gardner, L Gangi, M Yamaguchi, W Klomkleaw, T Nakayama, RL Hamlin, C Carnes, R Altschuld, J Bauer, T Hai |
The American Journal of Pathology | 2001 |
Heart Physiology and Pathophysiology
NS Dhalla, RM Temsah, T Netticadan, MS Sandhu |
Heart Physiology and Pathophysiology | 2001 |
Modelos animales genéticamente modificados en investigación cardiovascular
F Dalloz, H Osinska, J Robbins |
Revista Española de Cardiología | 2001 |
Manipulating the Contractile Apparatus: Genetically Defined Animal Models of Cardiovascular Disease
F Dalloz, H Osinska, J Robbins |
Journal of Molecular and Cellular Cardiology | 2001 |
Phenotypic Deficits in Mice Expressing a Myosin Binding Protein C Lacking the Titin and Myosin Binding Domains
Q Yang, H Osinska, R Klevitsky, J Robbins |
Journal of Molecular and Cellular Cardiology | 2001 |
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene
K Freeman, C Colon-Rivera, MC Olsson, RL Moore, HD Weinberger, IL Grupp, KL Vikstrom, G Iaccarino, WJ Koch, LA Leinwand |
American journal of physiology. Heart and circulatory physiology | 2001 |
Enhanced PKCβII translocation and PKCβII-RACK1 interactions in PKCε-induced heart failure: a role for RACK1
JM Pass, J Gao, WK Jones, WB Wead, X Wu, J Zhang, CP Baines, R Bolli, YT Zheng, IG Joshua, P Ping |
American journal of physiology. Heart and circulatory physiology | 2001 |
Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy
BJ Aronow, T Toyokawa, A Canning, K Haghighi, U Delling, E Kranias, JD Molkentin, GW Dorn |
Physiological genomics | 2001 |
Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy
DL Allen, BC Harrison, C Sartorius, WC Byrnes, LA Leinwand |
American journal of physiology. Cell physiology | 2001 |
Mouse Model of Desmin-Related Cardiomyopathy
X Wang, H Osinska, GW Dorn, M Nieman, JN Lorenz, AM Gerdes, S Witt, T Kimball, J Gulick, J Robbins |
Circulation | 2001 |
Increased Myocardial Rab GTPase Expression: A Consequence and Cause of Cardiomyopathy
G Wu, MG Yussman, TJ Barrett, HS Hahn, H Osinska, GM Hilliard, X Wang, T Toyokawa, A Yatani, RA Lynch, J Robbins, GW Dorn |
Circulation research | 2001 |
The Dual-Specificity Phosphatase MKP-1 Limits the Cardiac Hypertrophic Response In Vitro and In Vivo
OF Bueno, LJ Windt, HW Lim, KM Tymitz, SA Witt, TR Kimball, JD Molkentin |
Circulation research | 2001 |
Formation of the Heart and Its Regulation
RJ Tomanek, RB Runyan |
2001 | |
Cardiac Electrophysiology in Genetically Engineered Mice
J Gehrmann, CI Berul |
Journal of Cardiovascular Electrophysiology | 2000 |
Cardiac Dysfunction Occurs in the HIV-1 Transgenic Mouse Treated with Zidovudine
W Lewis, IL Grupp, G Grupp, B Hoit, R Morris, AM Samarel, L Bruggeman, P Klotman |
Laboratory Investigation | 2000 |
Inactivation of myosin heavy chain genes in the mouse: Diverse and unexpected phenotypes
DL Allen, BC Harrison, LA Leinwand |
Microscopy Research and Technique | 2000 |
Animal models of hypertrophic cardiomyopathy
A Maass, LA Leinwand |
Current Opinion in Cardiology | 2000 |
Remodeling the Cardiac Sarcomere Using Transgenesis
J Robbins |
Annual Review of Physiology | 2000 |
Protein kinase-A dependent phosphorylation of transcription enhancer factor-1 represses its DNA-binding activity but enhances its gene activation ability
MP Gupta, P Kogut, M Gupta |
Nucleic Acids Research | 2000 |
Serotonin 2B receptor is required for heart development
CG Nebigil, DS Choi, A Dierich, P Hickel, ML Meur, N Messaddeq, JM Launay, L Maroteaux |
Proceedings of the National Academy of Sciences | 2000 |
To the heart of myofibril assembly
CC Gregorio, PB Antin |
Trends in Cell Biology | 2000 |
Early Onset Heart Failure in Transgenic Mice with Dilated Cardiomyopathy
DG Hall, GE Morley, D Vaidya, M Ard, TR Kimball, SA Witt, MC Colbert |
Pediatric Research | 2000 |
Decreased left ventricular ejection fraction in transgenic mice expressing mutant cardiac troponin T-Q(92), responsible for human hypertrophic cardiomyopathy
DS Lim, L Oberst, M McCluggage, K Youker, J Lacy, F DeMayo, ML Entman, R Roberts, LH Michael, AJ Marian |
Journal of Molecular and Cellular Cardiology | 2000 |
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction
DD D'Angelo, Y Sakata, JN Lorenz, GP Boivin, RA Walsh, SB Liggett, GW 2nd |
Molecular pharmacology | 2000 |
Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects
JC Tardiff, TE Hewett, SM Factor, KL Vikstrom, J Robbins, LA Leinwand |
American journal of physiology. Heart and circulatory physiology | 2000 |
Cardiac-specific Overexpression of a Superinhibitory Pentameric Phospholamban Mutant Enhances Inhibition of Cardiac Function in Vivo
J Zhai, AG Schmidt, BD Hoit, Y Kimura, DH MacLennan, EG Kranias |
The Journal of biological chemistry | 2000 |
Identification and Genomic Cloning of CMHC1: A UNIQUE MYOSIN HEAVY CHAIN EXPRESSED EXCLUSIVELY IN THE DEVELOPING CHICKEN HEART
JD Croissant, S Carpenter, D Bader |
The Journal of biological chemistry | 2000 |
Transgenic Modeling of a Cardiac Troponin I Mutation Linked to Familial Hypertrophic Cardiomyopathy
J James, Y Zhang, H Osinska, A Sanbe, R Klevitsky, TE Hewett, J Robbins |
Circulation research | 2000 |
Calcineurin Expression, Activation, and Function in Cardiac Pressure-Overload Hypertrophy
HW Lim, LJ Windt, L Steinberg, T Taigen, SA Witt, TR Kimball, JD Molkentin |
Circulation | 2000 |
Chronic Elevation of Calmodulin in the Ventricles of Transgenic Mice Increases the Autonomous Activity of Calmodulin-Dependent Protein Kinase II, Which Regulates Atrial Natriuretic Factor Gene Expression
JM Colomer, AR Means |
Molecular Endocrinology | 2000 |
Transgenic Mouse Model of Stunned Myocardium
AM Murphy, H Kögler, D Georgakopoulos, JL McDonough, DA Kass, JE Eyk, E Marbán |
Science | 2000 |
Elastic Filaments of the Cell
HL Granzier, GH Pollack |
2000 | |
Dexamethasone induced cardiac hypertrophy in newborn rats is accompanied by changes in myosin heavy chain phenotype and gene transcription
S Muangmingsuk, P Ingram, M P Gupta, R A Arcilla, M Gupta |
Molecular and Cellular Biochemistry | 2000 |
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure
VP Sah, S Minamisawa, SP Tam, TH Wu, GW 2nd, J Ross, KR Chien, JH Brown |
Journal of Clinical Investigation | 1999 |
Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice
BK McConnell, KA Jones, D Fatkin, LH Arroyo, RT Lee, O Aristizabal, DH Turnbull, D Georgakopoulos, D Kass, M Bond, H Niimura, FJ Schoen, D Conner, DA Fischman, CE Seidman, JG Seidman, DH Fischman |
Journal of Clinical Investigation | 1999 |
MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium
SM Kolodziejczyk, L Wang, K Balazsi, Y DeRepentigny, R Kothary, LA Megeney |
Current Biology | 1999 |
Heart Development
GF Wang, FE Stockdale |
Heart Development | 1999 |
Transgenic replacement of type V adenylyl cyclase identifies a critical mechanism of beta-adrenergic receptor dysfunction in the G alpha q overexpressing mouse
NM Tepe, SB Liggett |
FEBS Letters | 1999 |
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy
S Minamisawa, M Hoshijima, G Chu, CA Ward, K Frank, Y Gu, ME Martone, Y Wang, J Ross, EG Kranias, WR Giles, KR Chien |
Cell | 1999 |
Ischemic Preconditioning Increases iNOS Transcript Levels in Conscious Rabbits via a Nitric Oxide-dependent Mechanism
WK Jones, MP Flaherty, XL Tang, H Takano, Y Qiu, S Banerjee, T Smith, R Bolli |
Journal of Molecular and Cellular Cardiology | 1999 |
Abnormal Cardiac Structure and Function in Mice Expressing Nonphosphorylatable Cardiac Regulatory Myosin Light Chain 2
A Sanbe, JG Fewell, J Gulick, H Osinska, J Lorenz, DG Hall, LA Murray, TR Kimball, SA Witt, J Robbins |
The Journal of biological chemistry | 1999 |
Cardiac-specific Overexpression of the α 1 Subunit of the L-type Voltage-dependent Ca 2+ Channel in Transgenic Mice: LOSS OF ISOPROTERENOL-INDUCED CONTRACTION
JN Muth, H Yamaguchi, G Mikala, IL Grupp, W Lewis, H Cheng, LS Song, EG Lakatta, G Varadi, A Schwartz |
The Journal of biological chemistry | 1999 |
Cardiac Specific Overexpression of Transglutaminase II (G h ) Results in a Unique Hypertrophy Phenotype Independent of Phospholipase C Activation
K Small, JF Feng, J Lorenz, ET Donnelly, A Yu, MJ Im, GW Dorn, SB Liggett |
The Journal of biological chemistry | 1999 |
A Post-transcriptional Compensatory Pathway in Heterozygous Ventricular Myosin Light Chain 2-Deficient Mice Results in Lack of Gene Dosage Effect during Normal Cardiac Growth or Hypertrophy
S Minamisawa, Y Gu, J Ross, KR Chien, J Chen |
The Journal of biological chemistry | 1999 |
Transgenic over-expression of a motor protein at high levels results in severe cardiac pathology
J James, H Osinska, T E Hewett, T Kimball, R Klevitsky, S Witt, D G Hall, J Gulick, J Robbins |
Transgenic Research | 1999 |
Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice
MA Sussman, S Welch, N Cambon, R Klevitsky, TE Hewett, R Price, SA Witt, TR Kimball |
Journal of Clinical Investigation | 1998 |
Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice
JG Fewell, TE Hewett, A Sanbe, R Klevitsky, E Hayes, D Warshaw, D Maughan, J Robbins |
Journal of Clinical Investigation | 1998 |
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
Q Yang, A Sanbe, H Osinska, TE Hewett, R Klevitsky, J Robbins |
Journal of Clinical Investigation | 1998 |
Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice
L Oberst, G Zhao, JT Park, R Brugada, LH Michael, ML Entman, R Roberts, AJ Marian |
Journal of Clinical Investigation | 1998 |
Why does the myocardium fail? Insights from basic science
MR Bristow |
The Lancet | 1998 |
Molecular Genetic Basis of Hypertrophic Cardiomyopathy:
AJ Marian, R Roberts |
Journal of Cardiovascular Electrophysiology | 1998 |
Genetically engineered mice: Model systems for left ventricular failure
VJ Kadambi, EG Kranias |
Journal of Cardiac Failure | 1998 |
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
Q Yang, A Sanbe, H Osinska, TE Hewett, R Klevitsky, J Robbins |
Journal of Clinical Investigation | 1998 |
Vertebrate homologs oftinman andbagpipe: Roles of the homeobox genes in cardiovascular development
M Tanaka, H Kasahara, S Bartunkova, M Schinke, I Komuro, H Inagaki, Y Lee, GE Lyons, S Izumo |
Developmental Genetics | 1998 |
Cardiac transgenic and gene-targeted mice as models of cardiac hypertrophy and failure: A problem of (new) riches
S Izumo, T Shioi |
Journal of Cardiac Failure | 1998 |
Cardiomyocytes and non-muscle cells in cardiac hypertrophy: a molecular perspective
M Gupta, MP Gupta, RA Arcilla, R Zak |
Progress in Pediatric Cardiology | 1998 |
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Jeffery D. Molkentin, Jian-Rong Lu, Christopher L. Antos, Bruce Markham, James Richardson, Jeffrey Robbins, Stephen R. Grant, Eric N. Olson |
Cell | 1998 |
Familial Hypertrophic Cardiomyopathy: From Mutations to Functional Defects
G Bonne, L Carrier, P Richard, B Hainque, K Schwartz |
Circulation research | 1998 |
Cardiac Physiology in Transgenic Mice
JF James, TE Hewett, J Robbins |
Circulation research | 1998 |
α-Tropomyosin Knockouts: A Blow Against Transcriptional Chauvinism
J Robbins |
Circulation research | 1998 |
Molecular and Physiological Effects of α-Tropomyosin Ablation in the Mouse
P Rethinasamy, M Muthuchamy, T Hewett, G Boivin, BM Wolska, C Evans, RJ Solaro, DF Wieczorek |
Circulation research | 1998 |
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.
Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN |
Cell | 1998 |
Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice
MC Colbert, DG Hall, TR Kimball, SA Witt, JN Lorenz, ML Kirby, TE Hewett, R Klevitsky, J Robbins |
Journal of Clinical Investigation | 1997 |
Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium
BD Lowes, W Minobe, WT Abraham, MN Rizeq, TJ Bohlmeyer, RA Quaife, RL Roden, DL Dutcher, AD Robertson, NF Voelkel, DB Badesch, BM Groves, EM Gilbert, MR Bristow |
Journal of Clinical Investigation | 1997 |
Molecular remodeling of cardiac contractile function
J James, J Robbins |
American journal of physiology. Heart and circulatory physiology | 1997 |
Targeted Ablation of the Murine α-Tropomyosin Gene
EM Blanchard, K Iizuka, M Christe, DA Conner, A Geisterfer-Lowrance, FJ Schoen, DW Maughan, CE Seidman, JG Seidman |
Circulation research | 1997 |
Manipulating Myosin Light Chain 2 Isoforms In Vivo: A Transgenic Approach to Understanding Contractile Protein Diversity
R Kelly, M Buckingham |
Circulation research | 1997 |
Fashioning the vertebrate heart: earliest embryonic decisions
MC Fishman, KR Chien |
Development (Cambridge, England) | 1997 |
Left Ventricular Hypertrophy
WS Aronow |
Journal of the American Geriatrics Society | 1992 |
International Review of Cytology
RA Miller |
International Review of Cytology | 1991 |
Time constant of isovolumic pressure fall: determinants in the working left ventricle
OF Bueno, LJ de Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, TE Hewett, SP Jones, DJ Lefer, CF Peng, RN Kitsis, JD Molkentin |
The American journal of physiology | 1978 |
Time constant of isovolumic pressure fall: determinants in the working left ventricle
OF Bueno, LJ de Windt, KM Tymitz, SA Witt, TR Kimball, R Klevitsky, TE Hewett, SP Jones, DJ Lefer, CF Peng, RN Kitsis, JD Molkentin |
The American journal of physiology | 1978 |