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H C Yen, … , Y S Ho, D K St Clair
Published September 1, 1996
Citation Information: J Clin Invest. 1996;98(5):1253-1260. https://doi.org/10.1172/JCI118909.
Citation Information: J Clin Invest. 1996;98(5):1253-1260. https://doi.org/10.1172/JCI118909.
Abstract
Adriamycin (ADR) is a potent anticancer drug known to cause severe cardiac toxicity. Although ADR generates free radicals, the role of free radicals in the development of cardiac toxicity and the intracellular target for ADR-induced cardiac toxicity are still not well understood. We produced three transgenic mice lines expressing increased levels of human manganese superoxide dismutase (MnSOD), a mitochondrial enzyme, as an animal model to investigate the role of ADR-mediated free radical generation in mitochondria. The human MnSOD was expressed, functionally active, and properly transported into mitochondria in the heart of transgenic mice. The levels of copper-zinc SOD, catalase, and glutathione peroxidase did not change in the transgenic mice. Electron microscopy revealed dose-dependent ultrastructural alterations with marked mitochondrial damage in nontransgenic mice treated with ADR, but not in the transgenic littermates. Biochemical analysis indicated that the levels of serum creatine kinase and lactate dehydrogenase in ADR-treated mice were significantly greater in nontransgenic than their transgenic littermates expressing a high level of human MnSOD after ADR treatment. These results support a major role for free radical generation in ADR toxicity as well as suggesting mitochondria as the critical site of cardiac injury.
Authors
H C Yen, T D Oberley, S Vichitbandha, Y S Ho, D K St Clair
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Citations to this article (377)
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Ranolazine in the prevention of anthracycline cardiotoxicity
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Pharmacological Research | 2014 |
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Ozone-Oxidative Preconditioning Prevents Doxorubicin-induced Cardiotoxicity in Sprague-Dawley Rats
L Delgado-Roche, Y Hernández-Matos, EA Medina, DÁ Morejón, MR González, G Martínez-Sánchez |
Sultan Qaboos University medical journal | 2014 |
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Mitochondria: The Anti- cancer Target for the Third Millennium
J Neuzil, S Pervaiz, S Fulda |
2014 | |
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Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria
WH Ibrahim, HM Habib, H Kamal, DK st Clair, CK Chow |
Free radical biology & medicine | 2013 |
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Redox Control of Cardiac Excitability
NT Aggarwal, JC Makielski |
Antioxidants & Redox Signaling | 2013 |
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Adrenergic signaling and oxidative stress: a role for sirtuins?
G Corbi, V Conti, G Russomanno, G Longobardi, G Furgi, A Filippelli, N Ferrara |
Frontiers in physiology | 2013 |
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The Use of the Cre/loxP System to Study Oxidative Stress in Tissue-Specific MnSOD Knockout Models
JC Marecki, N Parajuli, JP Crow, LA MacMillan-Crow |
Antioxidants & Redox Signaling | 2013 |
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Protective effect of saffron extract against doxorubicin cardiotoxicity in isolated rabbit heart
N Chahine, J Hanna, H Makhlouf, L Duca, L Martiny, R Chahine |
Pharmaceutical Biology | 2013 |
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Protective effect of mitochondrial ferritin on cytosolic iron dysregulation induced by doxorubicin in HeLa cells
E Cocco, V Porrini, M Derosas, V Nardi, G Biasiotto, F Maccarinelli, I Zanella |
Molecular Biology Reports | 2013 |
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Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection
M Štěrba, O Popelová, A Vávrová, E Jirkovský, P Kovaříková, V Geršl, T Šimůnek |
Antioxidants & Redox Signaling | 2013 |
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Pretreatment Effects of Regular Aerobic Training on the IGF System and Hepatotoxicity Induced by Doxorubicin in Rats
A Alishahi, VD Roshan, M Hedayyati |
Asian Pacific Journal of Cancer Prevention | 2013 |
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Doxorubicin-induced markers of myocardial autophagic signaling in sedentary and exercise trained animals
AJ Smuder, AN Kavazis, K Min, SK Powers |
Journal of applied physiology | 2013 |
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Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells
HR Kim, MH Jung, SY Lee, SM Oh, KH Chung |
The Journal of Toxicological Sciences | 2013 |
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Translating Metabolomics to Cardiovascular Biomarkers
T Senn, SL Hazen, WH Tang |
Progress in Cardiovascular Diseases | 2012 |
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Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle
MJ Boden, AE Brandon, JD Tid-Ang, E Preston, D Wilks, E Stuart, ME Cleasby, N Turner, GJ Cooney, EW Kraegen |
American journal of physiology. Endocrinology and metabolism | 2012 |
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Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein
M Szántó, A Brunyánszki, B Kiss, L Nagy, P Gergely, L Virág, P Bai |
Cellular and Molecular Life Sciences | 2012 |
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Curbing cancer's sweet tooth: Is there a role for MnSOD in regulation of the Warburg effect?
AK Holley, SK Dhar, DK st. Clair |
Mitochondrion | 2012 |
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Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz |
Protein Engineering for Therapeutics Part B | 2012 |
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Antioxidant and cardioprotective activity of Stachys schimperi Vatke against doxorubicin-induced cardiotoxicity
E Abdel-Sattar, SH El-Gayed, I Shehata, OM Ashour, AA Nagy, AM Mohamadin |
Bulletin of Faculty of Pharmacy Cairo University | 2012 |
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Lack of recovery from hepatic oxidative damage in rats treated with Nigerian bonny light crude oil : HEPATIC OXIDATIVE DAMAGE IN RATS TREATED WITH BONNY LIGHT CRUDE OIL
IA Adedara, EO Farombi |
Cell Biochemistry and Function | 2012 |
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Muscle
ML Martin, SL Belmonte, R Ram, FA Kamal, BC Blaxall |
Muscle | 2012 |
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Ghrelin and toxicity: recent findings and future challenges: Ghrelin and toxicity
I Vasileiou, D Patsouras, E Patsouris, S Theocharis |
Journal of Applied Toxicology | 2012 |
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The disruption of mitochondrial metabolism and ion homeostasis in chicken hearts exposed to manganese
JJ Shao, HD Yao, ZW Zhang, S Li, SW Xu |
Toxicology Letters | 2012 |
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Effets indésirables cardiaques des chimiothérapies
M Castel, F Despas, A Modesto, C Gales, B Honton, M Galinier, JM Senard, A Pathak |
La Presse Médicale | 2012 |
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Recent Advances in Cancer Research and Therapy
YL Lyu, LF Liu |
Recent Advances in Cancer Research and Therapy | 2012 |
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Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity
BJ Sishi, B Loos, J Rooyen, AM Engelbrecht |
Biochemical Pharmacology | 2012 |
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Biological Drugs: Classic Adverse Effects and New Clinical Evidences
PD Pina, E Vizzardi, R Raddino, M Gavazzoni, G Caretta, E Gorga, LD Cas |
Cardiovascular Toxicology | 2012 |
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Breast cancer treatment and adverse cardiac events: what are the molecular mechanisms?
L Roca-Alonso, L Pellegrino, L Castellano, J Stebbing |
Cardiology | 2012 |
|
Withaferin A suppresses tumor promoter 12- O -tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells
W Li, Y Zhao |
Cancer Science | 2012 |
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Oxidative stress and adult neurogenesis--effects of radiation and superoxide dismutase deficiency
TT Huang, Y Zou, R Corniola |
Seminars in Cell & Developmental Biology | 2012 |
|
Time- and dose-dependent differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase enzymatic activity and mRNA level by vitamin E in rat blood cells
M Hajiani, F Razi, A Golestani, M Frouzandeh, AA Owji, S Khaghani, N Ghannadian, A Shariftabrizi, P Pasalar |
Redox Report | 2012 |
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Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes
LA Gilliam, JS Moylan, EW Patterson, JD Smith, AS Wilson, Z Rabbani, MB Reid |
American journal of physiology. Cell physiology | 2012 |
|
Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle
MJ Boden, AE Brandon, JD Tid-Ang, E Preston, D Wilks, E Stuart, ME Cleasby, N Turner, GJ Cooney, EW Kraegen |
American journal of physiology. Endocrinology and metabolism | 2012 |
|
Withaferin A suppresses tumor promoter 12- O -tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells
W Li, Y Zhao |
Cancer Science | 2012 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Advances in Mitochondrial Medicine
R Scatena, P Bottoni, B Giardina |
Advances in Mitochondrial Medicine | 2011 |
|
Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle
AJ Smuder, AN Kavazis, K Min, SK Powers |
Journal of applied physiology | 2011 |
|
Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes
LA Gilliam, JS Moylan, EW Patterson, JD Smith, AS Wilson, Z Rabbani, MB Reid |
American journal of physiology. Cell physiology | 2011 |
|
Overexpression of nrdp1 in the heart exacerbates Doxorubicin-induced cardiac dysfunction in mice
Y Zhang, YM Kang, C Tian, Y Zeng, LX Jia, X Ma, J Du, HH Li |
PloS one | 2011 |
|
Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity
L Xi, SG Zhu, DC Hobbs, RC Kukreja |
Journal of Cellular and Molecular Medicine | 2011 |
|
Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity
RD Spagnuolo, S Recalcati, L Tacchini, G Cairo |
British Journal of Pharmacology | 2011 |
|
Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells
F Wang, J Liu, D Robbins, K Morris, A Sit, YY Liu, Y Zhao |
Apoptosis : an international journal on programmed cell death | 2011 |
|
Experimental depression induces renal oxidative stress in rats
A Pedreañez, JL Arcaya, E Carrizo, J Rincón, N Viera, C Peña, R Vargas, J Mosquera |
Physiology & Behavior | 2011 |
|
Dietary red palm oil protects the heart against the cytotoxic effects of anthracycline
A Wergeland, DJ Bester, BJ Sishi, AM Engelbrecht, AK Jonassen, JV Rooyen |
Cell Biochemistry and Function | 2011 |
|
Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q10 in human cells
HC Yen, FY Chen, SW Chen, YH Huang, YR Chen, CW Chen |
Journal of Biochemical and Molecular Toxicology | 2011 |
|
Anthracycline cardiotoxicity
P Menna, OG Paz, M Chello, E Covino, E Salvatorelli, G Minotti |
Expert Opinion on Drug Safety | 2011 |
|
Up-regulation of antioxidant enzymes and coenzyme Q10in a human oral cancer cell line with acquired bleomycin resistance
HC Yen, SH Li, HJ Majima, YH Huang, CP Chen, CC Liu, YC Tu, CW Chen |
Free Radical Research | 2011 |
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Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells
MB Chen, XY Wu, JH Gu, QT Guo, WX Shen, PH Lu |
Cell Biochemistry and Biophysics | 2011 |
|
Effect of hypothermia on doxorubicin-induced cardiac myoblast signaling and cell death
TJ L'Ecuyer, S Aggarwal, JP Zhang, RS van der Heide |
Cardiovascular Pathology | 2011 |
|
Pharmacogenetics of genes across the doxorubicin pathway
D Jamieson, AV Boddy |
Expert Opinion on Drug Metabolism & Toxicology | 2011 |
|
The antioxidant phenylaminoethyl selenide reduces doxorubicin-induced cardiotoxicity in a xenograft model of human prostate cancer
JY Kang, LJ Costyn, T Nagy, EA Cowan, CD Oldham, SW May, RD Arnold |
Archives of Biochemistry and Biophysics | 2011 |
|
Combined Proteomic and Molecular Approaches for Cloning and Characterization of Copper–Zinc Superoxide dismutase (Cu, Zn-SOD2) from Garlic (Allium sativum)
IH Sfaxi, A Ezzine, L Coquet, P Cosette, T Jouenne, MN Marzouki |
Molecular Biotechnology | 2011 |
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Manganese Superoxide Dismutase: Guardian of the Powerhouse
AK Holley, V Bakthavatchalu, JM Velez-Roman, DK st Clair |
International journal of molecular sciences | 2011 |
|
Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
M Szanto, I Rutkai, C Hegedus, A Czikora, M Rozsahegyi, B Kiss, L Virag, P Gergely, A Toth, P Bai |
Cardiovascular Research | 2011 |
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Global Effects of Adriamycin Treatment on Mouse Splenic Protein Levels
RA Robinson, AR Evans, S Miriyala, DS Clair, DA Butterfield |
Journal of Proteome Research | 2011 |
|
Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress
LA Gilliam, DK st Clair |
Antioxidants & Redox Signaling | 2011 |
|
Resveratrol attenuates doxorubicin-induced cardiomyocyte death via inhibition of p70 S6 kinase 1-mediated autophagy
X Xu, K Chen, S Kobayashi, D Timm, Q Liang |
The Journal of pharmacology and experimental therapeutics | 2011 |
|
BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure
KK Singh, PC Shukla, A Quan, JF Desjardins, F Lovren, Y Pan, V Garg, S Gosal, A Garg, PE Szmitko, MD Schneider, TG Parker, WL Stanford, H Leong-Poi, H Teoh, M Al-Omran, S Verma |
The Journal of biological chemistry | 2011 |
|
Overexpression of Nrdp1 in the Heart Exacerbates Doxorubicin-Induced Cardiac Dysfunction in Mice
Y Zhang, YM Kang, C Tian, Y Zeng, LX Jia, X Ma, J Du, HH Li, V Cheriyath |
PloS one | 2011 |
|
Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle
AJ Smuder, AN Kavazis, K Min, SK Powers |
Journal of applied physiology | 2011 |
|
Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes
T Feridooni, A Hotchkiss, S Remley-Carr, Y Saga, KB Pasumarthi, C Gaetano |
PloS one | 2011 |
|
Tissues distribution of heavy metals and erythrocytes antioxidant status in rats exposed to Nigerian bonny light crude oil
IA Adedara, AP Ebokaiwe, EO Farombi |
Toxicology and industrial health | 2011 |
|
Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle
AJ Smuder, AN Kavazis, K Min, SK Powers |
Journal of applied physiology | 2011 |
|
Molecular Defects in Cardiovascular Disease
NS Dhalla, M Nagano, B Ostadal |
2011 | |
|
Manganese Superoxide Dismutase Is a p53 -Regulated Gene That Switches Cancers between Early and Advanced Stages
SK Dhar, J Tangpong, L Chaiswing, TD Oberley, DK Clair |
Cancer research | 2011 |
|
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
M Tanno, A Kuno, T Yano, T Miura, S Hisahara, S Ishikawa, K Shimamoto, Y Horio |
The Journal of biological chemistry | 2010 |
|
Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72
AN Kavazis, AJ Smuder, K Min, N Tümer, SK Powers |
American journal of physiology. Heart and circulatory physiology | 2010 |
|
Androgen receptor counteracts Doxorubicin-induced cardiotoxicity in male mice
Y Ikeda, K Aihara, M Akaike, T Sato, K Ishikawa, T Ise, S Yagi, T Iwase, Y Ueda, S Yoshida, H Azuma, K Walsh, T Tamaki, S Kato, T Matsumoto |
Molecular Endocrinology | 2010 |
|
Mechanisms of Anthracycline Cardiac Injury: Can we identify strategies for cardio-protection?
DB Sawyer, X Peng, B Chen, L Pentassuglia, CC Lim |
Progress in Cardiovascular Diseases | 2010 |
|
Manganese superoxide dismutase: beyond life and death
AK Holley, SK Dhar, Y Xu, DK st. Clair |
Amino Acids | 2010 |
|
Mechanisms of Anthracycline Cardiotoxicity and Strategies to Decrease Cardiac Damage
CA Geisberg, DB Sawyer |
Current Hypertension Reports | 2010 |
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Effect of Naringin on the DNA Damage Induced by Daunorubicin in Mouse Hepatocytes and Cardiocytes
R CariÑo-Cortés, I Álvarez-González, L Martino-Roaro, E Madrigal-Bujaidar |
Biological & Pharmaceutical Bulletin | 2010 |
|
Cardiac side-effects of cancer chemotherapy
JJ Monsuez, JC Charniot, N Vignat, JY Artigou |
International Journal of Cardiology | 2010 |
|
Sodium selenate effect on Synechococcus elongatus PCC 7942: appearance of novel enzymatic reaction, ATP:selenate adenylyltransferase, and variation in antioxidant enzyme activities
M Saggu, A Jain, D Bagchi |
Journal of Basic Microbiology | 2010 |
|
Rational Design of Multifunctional Polymer Therapeutics for Cancer Theranostics
P Ofek, K Miller, A Eldar-Boock, D Polyak, E Segal, R Satchi-Fainaro |
Israel Journal of Chemistry | 2010 |
|
Attenuation of Doxorubicin-induced Cardiotoxicity by Tadalafil: A Long Acting Phosphodiesterase-5 Inhibitor
S Koka, RC Kukreja |
Molecular and cellular pharmacology | 2010 |
|
Mitochondrial Fe-S cluster biogenesis, frataxin and the modulation of susceptibility to drug-induced cardiomyopathy
MN Sack |
Aging | 2010 |
|
Doxycycline suppresses doxorubicin-induced oxidative stress and cellular apoptosis in mouse hearts
HC Lai, YC Yeh, CT Ting, WL Lee, HW Lee, LC Wang, KY Wang, HC Lai, A Wu, TJ Liu |
European Journal of Pharmacology | 2010 |
|
Preparation of the core-shell structure adriamycin lipiodol microemulsions and their synergistic anti-tumor effects with diethyldithiocarbamate in vivo
W Daocheng, W Mingxi |
Biomedicine & Pharmacotherapy | 2010 |
|
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats
AA Elberry, AB Abdel-Naim, EA Abdel-Sattar, AA Nagy, HA Mosli, AM Mohamadin, OM Ashour |
Food and Chemical Toxicology | 2010 |
|
A toxicoproteomic study on cardioprotective effects of pre-administration of docetaxel in a mouse model of adriamycin-induced cardiotoxicity
K Ohyama, M Tomonari, T Ichibangase, H To, N Kishikawa, K Nakashima, K Imai, N Kuroda |
Biochemical Pharmacology | 2010 |
|
Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound
T Bordet, P Berna, JL Abitbol, RM Pruss |
Pharmaceuticals (Basel, Switzerland) | 2010 |
|
Androgen Receptor Counteracts Doxorubicin-Induced Cardiotoxicity in Male Mice
Y Ikeda, K Aihara, M Akaike, T Sato, K Ishikawa, T Ise, S Yagi, T Iwase, Y Ueda, S Yoshida, H Azuma, K Walsh, T Tamaki, S Kato, T Matsumoto |
Molecular Endocrinology | 2010 |
|
Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72
AN Kavazis, AJ Smuder, K Min, N Tümer, SK Powers |
American journal of physiology. Heart and circulatory physiology | 2010 |
|
Long-Acting Phosphodiesterase-5 Inhibitor Tadalafil Attenuates Doxorubicin-Induced Cardiomyopathy without Interfering with Chemotherapeutic Effect
S Koka, A Das, SG Zhu, D Durrant, , RC Kukreja |
The Journal of pharmacology and experimental therapeutics | 2010 |
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Taurine 7
J Azuma, SW Schaffer, T Ito |
2009 | |
|
Taurine 7
J Azuma, SW Schaffer, T Ito |
2009 | |
|
Taurine 7
J Azuma, SW Schaffer, T Ito |
2009 | |
|
Taurine 7
J Azuma, SW Schaffer, T Ito |
2009 | |
|
Taurine 7
J Azuma, SW Schaffer, T Ito |
2009 | |
|
Taurine 7
J Azuma, SW Schaffer, T Ito |
2009 | |
|
Taurine 7
J Azuma, SW Schaffer, T Ito |
2009 | |
|
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death
S Kobayashi, P Volden, D Timm, K Mao, X Xu, Q Liang |
The Journal of biological chemistry | 2009 |
|
Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice
S Deng, A Kruger, A Schmidt, A Metzger, T Yan, U Gödtel-Armbrust, G Hasenfuss, F Brunner, L Wojnowski |
Naunyn-Schmiedeberg's Archives of Pharmacology | 2009 |
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Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
ED Danz, J Skramsted, N Henry, JA Bennett, RS Keller |
Free radical biology & medicine | 2009 |
|
Protective effect of tetrahydroxystilbene glucoside on cardiotoxicity induced by doxorubicin in vitro and in vivo
S Zhang, W Wang, J Wang |
Acta Pharmacologica Sinica | 2009 |
|
Repeated Systemic Escherichia coli Infection Enhances Anti-oxidant Response in Hypercholesterolemic Mice Inducing Cardiovascular Inflammation
K Dutta, D Nandi, B Bishayi |
Inflammation | 2009 |
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Metabonomic identification of novel biomarkers in doxorubicin cardiotoxicity and protective effect of the natural antioxidant oleuropein
I Andreadou, M Papaefthimiou, A Zira, M Constantinou, F Sigala, AL Skaltsounis, A Tsantili-Kakoulidou, EK Iliodromitis, DT Kremastinos, E Mikros |
NMR in Biomedicine | 2009 |
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Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy
YW Su, C Liang, HF Jin, XY Tang, W Han, LJ Chai, CY Zhang, B Geng, CS Tang, JB Du |
Circulation Journal | 2009 |
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Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression
D Yao, H Li, Y Gou, H Zhang, AG Vlessidis, H Zhou, NP Evmiridis, Z Liu |
FEBS Journal | 2009 |
|
Enhancing the antitumor activity of adriamycin and ionizing radiation
W Sun, AL Kalen, BJ Smith, JJ Cullen, LW Oberley |
Cancer research | 2009 |
|
Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells
MC Jaramillo, JB Frye, JD Crapo, MM Briehl, ME Tome |
Cancer research | 2009 |
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Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity
M Yoshida, I Shiojima, H Ikeda, I Komuro |
Journal of Molecular and Cellular Cardiology | 2009 |
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Anandamide Preserves Cardiac Function and Geometry in an Acute Doxorubicin Cardiotoxicity Rat Model
DS Hydock, CY Lien, R Hayward |
Journal of cardiovascular pharmacology and therapeutics | 2009 |
|
Cruciferous Dithiolethione-Mediated Coordinated Induction of Total Cellular and Mitochondrial Antioxidants and Phase 2 Enzymes in Human Primary Cardiomyocytes: Cytoprotection Against Oxidative/Electrophilic Stress and Doxorubicin Toxicity
H Zhu, Z Jia, K Zhou, HP Misra, A Santo, KL Gabrielson, Y Li |
Experimental biology and medicine (Maywood, N.J.) | 2009 |
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Attenuation of doxorubicin-induced cardiac injury by mitochondrial glutaredoxin 2
NM Diotte, Y Xiong, J Gao, BH Chua, YS Ho |
Biochimica et Biophysica Acta | 2008 |
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A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury
P Sompol, W Ittarat, J Tangpong, Y Chen, I Doubinskaia, I Batinic-Haberle, HM Abdul, DA Butterfield, DK st Clair |
Neuroscience | 2008 |
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Therapy Insight: anthracyclines and trastuzumab—the optimal management of cardiotoxic side effects
S Popat, IE Smith |
Nature Clinical Practice Oncology | 2008 |
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Herpes simplex virus type 1 ICP27 induces apoptotic cell death by increasing intracellular reactive oxygen species
JC Kim, SH Choi, JK Kim, SY Kim, HJ Kim, JS Im, SY Lee, JM Choi, HM Lee, JK Ahn |
Molecular Biology | 2008 |
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Mitochondrial oxidative stress and dysfunction in myocardial remodelling
H Tsutsui, S Kinugawa, S Matsushima |
Cardiovascular Research | 2008 |
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Ghrelin prevents doxorubicin-induced cardiotoxicity through TNF-alpha/NF-κB pathways and mitochondrial protective mechanisms
Z Xu, S Lin, W Wu, H Tan, Z Wang, C Cheng, L Lu, X Zhang |
Toxicology | 2008 |
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Effect of Terminalia arjuna extract on adriamycin-induced DNA damage
TK Reddy, P Seshadri, KK Reddy, GC Jagetia, CD Reddy |
Phytotherapy Research | 2008 |
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Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity
J Gao, Y Xiong, YS Ho, X Liu, CC Chua, X Xu, H Wang, R Hamdy, BH Chua |
Biochimica et Biophysica Acta | 2008 |
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Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes
X Han, J Pan, D Ren, Y Cheng, P Fan, H Lou |
Food and Chemical Toxicology | 2008 |
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Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis
J Gao, G Yang, R Pi, R Li, P Wang, H Zhang, K Le, S Chen, P Liu |
Translational Research | 2008 |
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Complications cardiaques des maladies malignes et de leurs traitements
JJ Monsuez, JC Charniot, N Vignat |
EMC - Cardiologie | 2008 |
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Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage
S Cardoso, RX Santos, C Carvalho, S Correia, GC Pereira, SS Pereira, PJ Oliveira, MS Santos, T Proença, PI Moreira |
Free radical biology & medicine | 2008 |
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Two Allelic Variants of Aldo-Keto Reductase 1A1 Exhibit Reduced in Vitro Metabolism of Daunorubicin
OS Bains, RH Takahashi, TA Pfeifer, TA Grigliatti, RE Reid, KW Riggs |
Drug Metabolism and Disposition | 2008 |
|
Mutations of mitochondrial DNA – cause or consequence of the ageing process?
C Meissner |
Zeitschrift für Gerontologie und Geriatrie | 2007 |
|
Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase
D Hu, P Cao, E Thiels, CT Chu, GY Wu, TD Oury, E Klann |
Neurobiology of Learning and Memory | 2007 |
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Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice
AM Bruynzeel, MA el Hassan, C Schalkwijk, J Berkhof, A Bast, HW Niessen, WJ van der Vijgh |
British Journal of Cancer | 2007 |
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Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain
J Tangpong, MP Cole, R Sultana, S Estus, M Vore, WS Clair, S Ratanachaiyavong, DK st. Clair, DA Butterfield |
Journal of Neurochemistry | 2007 |
|
Genotyping the risk of anthracycline-induced cardiotoxicity
S Deng, L Wojnowski |
Cardiovascular Toxicology | 2007 |
|
Molecular and cellular mechanisms of anthracycline cardiotoxicity
B Chen, X Peng, L Pentassuglia, CC Lim, DB Sawyer |
Cardiovascular Toxicology | 2007 |
|
Mitochondrial and Nuclear p53 Localization in Cardiomyocytes: Redox Modulation by Doxorubicin (Adriamycin)?
R Nithipongvanitch, W Ittarat, MP Cole, J Tangpong, DK st. Clair, TD Oberley |
Antioxidants & Redox Signaling | 2007 |
|
Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage
X Shan, L Chi, Y Ke, C Luo, S Qian, D Gozal, R Liu |
Neurobiology of Disease | 2007 |
|
Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: the negative role of p50
SK Dhar, Y Xu, T Noel, DK st Clair |
Carcinogenesis | 2007 |
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Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury
C Daosukho, Y Chen, T Noel, P Sompol, R Nithipongvanitch, JM Velez, TD Oberley, DK st Clair |
Free radical biology & medicine | 2007 |
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TNF alpha-mediated NO production enhances MnSOD nitration and mitochondrial dysfunction in primary neurons: An insight into the role of glial cells
J Tangpong, P Sompol, M Vore, WS Clair, DA Butterfield, DK st Clair |
Neuroscience | 2007 |
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Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity
S Ichihara, Y Yamada, Y Kawai, T Osawa, K Furuhashi, Z Duan, G Ichihara |
Biochemical and Biophysical Research Communications | 2007 |
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CCN1 protects cardiac myocytes from oxidative stress via β1 integrin–Akt pathway
Y Yoshida, K Togi, H Matsumae, Y Nakashima, Y Kojima, H Yamamoto, K Ono, T Nakamura, T Kita, M Tanaka |
Biochemical and Biophysical Research Communications | 2007 |
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Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress
I Andreadou, F Sigala, EK Iliodromitis, M Papaefthimiou, C Sigalas, N Aligiannis, P Savvari, V Gorgoulis, E Papalabros, DT Kremastinos |
Journal of Molecular and Cellular Cardiology | 2007 |
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The Role of a Single-stranded Nucleotide Loop in Transcriptional Regulation of the Human sod2 Gene
Y Xu, F Fang, SK Dhar, WH st. Clair, EJ Kasarskis, DK st. Clair |
The Journal of biological chemistry | 2007 |
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Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats
MN Ansari, U Bhandari, KK Pillai |
Human & Experimental Toxicology | 2007 |
|
Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions
Y Zhao, L Wang, L Chaiswing, H Yen, TD Oberley, Y Lien, S Lin, MP Mattson, DS Clair |
Free radical biology & medicine | 2006 |
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Beneficial role of aminoguanidine on acute cardiomyopathy related to doxorubicin-treatment
Y Cigremis, H Parlakpinar, A Polat, C Colak, F Ozturk, E Sahna, N Ermis, A Acet |
Molecular and Cellular Biochemistry | 2006 |
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A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration
T Hofer, AY Seo, M Prudencio, C Leeuwenburgh |
Biological Chemistry | 2006 |
|
Exercise Training Attenuates Acute Doxorubicin-Induced Cardiac Dysfunction
AJ Chicco, CM Schneider, R Hayward |
Journal of Cardiovascular Pharmacology | 2006 |
|
C-Phycocyanin Ameliorates Doxorubicin-Induced Oxidative Stress and Apoptosis in Adult Rat Cardiomyocytes
M Khan, S Varadharaj, JC Shobha, MU Naidu, NL Parinandi, VK Kutala, P Kuppusamy |
Journal of Cardiovascular Pharmacology | 2006 |
|
Superoxide Dismutase and Hippocampal Function: Age and Isozyme Matter
D Hu, E Klann, E Thiels |
Antioxidants & Redox Signaling | 2006 |
|
Mn-Superoxide Dismutase Overexpression Enhances G2Accumulation and Radioresistance in Human Oral Squamous Carcinoma Cells
AL Kalen, EH Sarsour, S Venkataraman, PC Goswami |
Antioxidants & Redox Signaling | 2006 |
|
Attenuation of doxorubicin-induced contractile and mitochondrial dysfunction in mouse heart by cellular glutathione peroxidase
Y Xiong, X Liu, CP Lee, BH Chua, YS Ho |
Free radical biology & medicine | 2006 |
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Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells
A Vasilaki, M Csete, D Pye, S Lee, J Palomero, F McArdle, HV Remmen, A Richardson, A McArdle, JA Faulkner, MJ Jackson |
Free radical biology & medicine | 2006 |
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Redox proteomic identification of oxidized cardiac proteins in Adriamycin-treated mice
Y Chen, C Daosukho, WO Opii, DM Turner, WM Pierce, JB Klein, M Vore, DA Butterfield, DK st. Clair |
Free radical biology & medicine | 2006 |
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Adriamycin-induced, TNF-α-mediated central nervous system toxicity
J Tangpong, MP Cole, R Sultana, G Joshi, S Estus, M Vore, WS Clair, S Ratanachaiyavong, DK st. Clair, DA Butterfield |
Neurobiology of Disease | 2006 |
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Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival
RC Martin, J Ahn, SA Nowell, DW Hein, MA Doll, BD Martini, CB Ambrosone |
Breast Cancer Research | 2006 |
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Doxorubicin prevents endoplasmic reticulum stress-induced apoptosis
SJ Kim, KM Park, N Kim, YI Yeom |
Biochemical and Biophysical Research Communications | 2006 |
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Prévention de la cardiotoxicité des anthracyclines : approche fondamentale des mécanismes mis en jeu ; relations avec les données cliniques
S Delemasure, C Vergely, M Zeller, Y Cottin, L Rochette |
Annales de Cardiologie et d Angéiologie | 2006 |
|
Protection of Cardiac Mitochondria by Overexpression of MnSOD Reduces Diabetic Cardiomyopathy
X Shen, S Zheng, NS Metreveli, PN Epstein |
Diabetes | 2006 |
|
Iloprost attenuates doxorubicin-induced cardiac injury in a murine model without compromising tumour suppression
TG Neilan, DS Jassal, MF Scully, G Chen, C Deflandre, H McAllister, E Kay, SC Austin, EF Halpern, JH Harmey, DJ Fitzgerald |
European Heart Journal | 2006 |
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Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity
AJ Chicco, DS Hydock, CM Schneider, R Hayward |
Journal of applied physiology | 2006 |
|
Transcriptional analysis of doxorubicin-induced cardiotoxicity
X Yi, R Bekeredjian, NJ DeFilippis, Z Siddiquee, E Fernandez, RV Shohet |
American journal of physiology. Heart and circulatory physiology | 2006 |
|
DNA damage is an early event in doxorubicin-induced cardiac myocyte death
T L'Ecuyer, S Sanjeev, R Thomas, R Novak, L Das, W Campbell, RV Heide |
American journal of physiology. Heart and circulatory physiology | 2006 |
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C/EBPβ regulates TNF induced MnSOD expression and protection against apoptosis
P Ranjan, JM Boss |
Apoptosis | 2006 |
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Polymer Therapeutics II
R Satchi-Fainaro, R Duncan |
2006 | |
|
Oxygen, oxidative stress, hypoxia, and heart failure
FJ Giordano |
Journal of Clinical Investigation | 2005 |
|
Protective effect ofSpirulina against doxorubicin-induced cardiotoxicity
M Khan, JC Shobha, IK Mohan, MU Naidu, C Sundaram, S Singh, P Kuppusamy, VK Kutala |
Phytotherapy Research | 2005 |
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Carcinogenic effect of nickel compounds
H Lu, X Shi, M Costa, C Huang |
Molecular and Cellular Biochemistry | 2005 |
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Increased Reactive Oxygen Species Production and Functional Alterations in Antioxidant Enzymes in Human Failing Myocardium
F Sam, DL Kerstetter, DR Pimental, S Mulukutla, A Tabaee, MR Bristow, WS Colucci, DB Sawyer |
Journal of Cardiac Failure | 2005 |
|
Antioxidative and Cardioprotective Effects of Phyllanthus urinaria L. on Doxorubicin-Induced Cardiotoxicity
L Chularojmontri, SK Wattanapitayakul, A Herunsalee, S Charuchongkolwongse, S Niumsakul, S Srichairat |
Biological & Pharmaceutical Bulletin | 2005 |
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Post-Translational Modification of Manganese Superoxide Dismutase in Acutely Rejecting Cardiac Transplants: Role of Inducible Nitric Oxide Synthase
V Nilakantan, NL Halligan, TK Nguyen, G Hilton, AK Khanna, AM Roza, CP Johnson, MB Adams, OW Griffith, GM Pieper |
The Journal of Heart and Lung Transplantation | 2005 |
|
Levels of reactive oxygen species and primary antioxidant enzymes in WI38 versus transformed WI38 cells following bleomcyin treatment
HC Yen, HM Chang, HJ Majima, FY Chen, SH Li |
Free radical biology & medicine | 2005 |
|
Radiation Protects Adriamycin-Induced Apoptosis
HJ Chae, HR Kim, WG Lee, YK Kwak, WH Kim, ST Hong, GH Cho, JS Kim, SW Chae |
Immunopharmacology and Immunotoxicology | 2005 |
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Tetrathiomolybdate protects against cardiac damage by doxorubicin in mice
G Hou, R Dick, GD Abrams, GJ Brewer |
Journal of Laboratory and Clinical Medicine | 2005 |
|
Doxorubicin induces cardiomyocyte dysfunction via a p38 MAP kinase-dependent oxidative stress mechanism
LE Wold, NS Aberle, J Ren |
Cancer Detection and Prevention | 2005 |
|
Chronic oral administration of Ocimum sanctum Linn. augments cardiac endogenous antioxidants and prevents isoproterenol-induced myocardial necrosis in rats
S Sood, D Narang, A K Dinda, S K Maulik |
The Journal of pharmacy and pharmacology | 2005 |
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Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis
A Ascensão, J Magalhães, JM Soares, R Ferreira, MJ Neuparth, F Marques, PJ Oliveira, JA Duarte |
American journal of physiology. Heart and circulatory physiology | 2005 |
|
Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart
AJ Chicco, CM Schneider, R Hayward |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2005 |
|
Acute and severe hypobaric hypoxia increases oxidative stress and impairs mitochondrial function in mouse skeletal muscle
J Magalhães, A Ascensão, JM Soares, R Ferreira, MJ Neuparth, F Marques, JA Duarte |
Journal of applied physiology | 2005 |
|
Cardiotoxicity of Cancer Chemotherapy: Implications for Children
VC Simbre, SA Duffy, GH Dadlani, TL Miller, SE Lipshultz |
Pediatric Drugs | 2005 |
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A novel thiol oxidation‐based mechanism for adriamycin‐induced cell injury in human macrophages
R Asmis, Y Wang, L Xu, M Kisgati, JG Begley, JJ Mieyal |
The FASEB Journal | 2005 |
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Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats
YM Jang, S Kendaiah, B Drew, T Phillips, C Selman, D Julian, C Leeuwenburgh |
FEBS Letters | 2004 |
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Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
G Minotti, P Menna, E Salvatorelli, G Cairo, L Gianni |
Pharmacological reviews | 2004 |
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Mitochondrial Signal Lacking Manganese Superoxide Dismutase Failed to Prevent Cell Death by Reoxygenation Following Hypoxia in a Human Pancreatic Cancer Cell Line, KP4
F Hirai, S Motoori, S Kakinuma, K Tomita, HP Indo, H Kato, T Yamaguchi, HC Yen, DK st. Clair, T Nagano, T Ozawa, H Saisho, HJ Majima |
Antioxidants & Redox Signaling | 2004 |
|
Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury
Z Cao, Y Li |
European Journal of Pharmacology | 2004 |
|
In SituReduction of Oxidative Damage, Increased Cell Turnover, and Delay of Mitochondrial Injury by Overexpression of Manganese Superoxide Dismutase in a Multistage Skin Carcinogenesis Model
TD Oberley, Y Xue, Y Zhao, K Kiningham, LI Szweda, DK st. Clair |
Antioxidants & Redox Signaling | 2004 |
|
Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide
CH Lillig, ME Lönn, M Enoksson, AP Fernandes, A Holmgren |
Proceedings of the National Academy of Sciences | 2004 |
|
Method for determination of (-102C>T) single nucleotide polymorphism in the human manganese superoxide dismutase promoter
RC Martin, K Hughes, MA Doll, Q Lan, BD Martini, J Lissowska, N Rothman, DW Hein |
BMC genetics | 2004 |
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Increased oxidative stress and apoptosis in acute puromycin aminonucleoside nephrosis
J Rincon, M Romero, N Viera, A Pedreañez, J Mosquera |
International Journal of Experimental Pathology | 2004 |
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Frataxin overexpressing mice
CJ Miranda, MM Santos, K Ohshima, M Tessaro, J Sequeiros, M Pandolfo |
FEBS Letters | 2004 |
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La cardiotoxicité des anthracyclines : mécanismes et cibles pharmacologiques de prévention
N Andrieu-Abadie |
Thérapie | 2004 |
|
Identification of Nucleophosmin as an NF-κB Co-activator for the Induction of the Human SOD2 Gene
SK Dhar, BC Lynn, C Daosukho, DK st. Clair |
The Journal of biological chemistry | 2004 |
|
Glutathione S -transferase overexpression protects against anthracycline-induced H9C2 cell death
T L'Ecuyer, Z Allebban, R Thomas, RV Heide |
American journal of physiology. Heart and circulatory physiology | 2004 |
|
Oxidative Damage Precedes Nitrative Damage in Adriamycin-Induced Cardiac Mitochondrial Injury
L Chaiswing, MP Cole, DK st. Clair, W Ittarat, LI Szweda, TD Oberley |
Toxicologic pathology | 2004 |
|
IκBα (inhibitory κBα) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression
KK KININGHAM, C DAOSUKHO, DK CLAIR |
Biochemical Journal | 2004 |
|
Doxorubicin-Induced Cardiac Mitochondrionopathy
KB Wallace |
Pharmacology and Toxicology | 2003 |
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Mnsod overexpression extends the yeast chronological (G0) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells
N Harris, V Costa, M MacLean, M Mollapour, P Moradas-Ferreira, PW Piper |
Free radical biology & medicine | 2003 |
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An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation
ME Fernandez-Zapico, A Mladek, V Ellenrieder, E Folch-Puy, L Miller, R Urrutia |
The EMBO Journal | 2003 |
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Decreased survival of prostate cancer cells in vitro by combined treatment of heat and an antioxidant inhibitor diethyldithiocarbamate (DDC)
N Moriyama-Gonda, M Igawa, H Shiina, S Urakami, M Terashima |
Experimental and Toxicologic Pathology | 2003 |
|
Mitochondrial complex I, aconitase, and succinate dehydrogenase during hypoxia-reoxygenation: modulation of enzyme activities by MnSOD
CS Powell, RM Jackson |
American journal of physiology. Lung cellular and molecular physiology | 2003 |
|
The protective effect of cardiac gene transfer of CuZn–sod in comparison with the cardioprotector monohydroxyethylrutoside against doxorubicin-induced cardiotoxicity in cultured cells
MA el Hassan, M Heijn, MJ Rabelink, WJ van der Vijgh, A Bast, RC Hoeben |
Cancer Gene Therapy | 2003 |
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Differential Effects of Superoxide Dismutase Isoform Expression on Hydroperoxide-induced Apoptosis in PC-12 Cells
EK Pias, OY Ekshyyan, CA Rhoads, J Fuseler, L Harrison, TY Aw |
The Journal of biological chemistry | 2003 |
|
Myocardial Ischemia and Preconditioning
NS Dhalla, N Takeda, M Singh, A Lukas |
2003 | |
|
Aging of Organisms
HD Osiewacz |
2003 | |
|
Heat shock inactivates cellular antioxidant defenses against hydrogen peroxide: protection by glucose
S Lord-Fontaine, DA Averill-Bates |
Free radical biology & medicine | 2002 |
|
Intracellular distribution of peroxynitrite during doxorubicin cardiomyopathy: evidence for selective impairment of myofibrillar creatine kinase
MJ Mihm, F Yu, DM Weinstein, PJ Reiser, JA Bauer |
British Journal of Pharmacology | 2002 |
|
Animal models of oxidative stress, aging, and therapeutic antioxidant interventions
S Melov |
The International Journal of Biochemistry & Cell Biology | 2002 |
|
Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2)
Y Xu, S Porntadavity, DK st Clair |
Biochemical Journal | 2002 |
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Advances in Cell Aging and Gerontology
T Fülöp, K Hirokawa, G Dupuis, A Larbi, G Pawelec |
Advances in Cell Aging and Gerontology | 2002 |
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Hyperglycemia-Induced Apoptosis in Mouse Myocardium: Mitochondrial Cytochrome c-Mediated Caspase-3 Activation Pathway
L Cai, W Li, G Wang, L Guo, Y Jiang, YJ Kang |
Diabetes | 2002 |
|
Transgenic and Knockout Models for Studying the Role of Lung Antioxidant Enzymes in Defense against Hyperoxia
YS Ho |
American journal of respiratory and critical care medicine | 2002 |
|
La mitocondria y el corazón
J Marín-García, MJ Goldenthal |
Revista Española de Cardiología | 2002 |
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Understanding the impact of mitochondrial defects in cardiovascular disease: A review
J Marín-García, MJ Goldenthal |
Journal of Cardiac Failure | 2002 |
|
Elevated Myocardial Akt Signaling Ameliorates Doxorubicin-induced Congestive Heart Failure and Promotes Heart Growth
Y Taniyama, K Walsh |
Journal of Molecular and Cellular Cardiology | 2002 |
|
Induction of cellular glutathione-linked enzymes and catalase by the unique chemoprotective agent, 3H-1,2-dithiole-3-thione in rat cardiomyocytes affords protection against oxidative cell injury
X Peng, Y Li |
Pharmacological Research | 2002 |
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Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis
Pattie S Green, Christiaan Leeuwenburgh |
Biochimica et Biophysica Acta | 2002 |
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Correlation of Simultaneous Differential Gene Expression in the Blood and Heart with Known Mechanisms of Adriamycin-Induced Cardiomyopathy in the Rat
HR Brown, H Ni, G Benavides, L Yoon, K Hyder, J Giridhar, G Gardner, RD Tyler, KT Morgan |
Toxicologic pathology | 2002 |
|
Melatonin as an effective protector against doxorubicin-induced cardiotoxicity
X Liu, Z Chen, CC Chua, YS Ma, GA Youngberg, R Hamdy, BH Chua |
American journal of physiology. Heart and circulatory physiology | 2002 |
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Overexpression of Thioredoxin-1 in Transgenic Mice Attenuates Adriamycin-Induced Cardiotoxicity
K Shioji, C Kishimoto, H Nakamura, H Masutani, Z Yuan, S Oka, J Yodoi |
Circulation | 2002 |
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Mitochondria in Pathogenesis
JJ Lemasters, AL Nieminen |
2002 | |
|
Early changes in myocardial antioxidant enzymes in rats treated with adriamycin
Timao Li, Igor Danelisen, Pawan K Singal |
Molecular and Cellular Biochemistry | 2002 |
|
Mitochondria as subcellular targets for clinically useful anthracyclines
K Jung, R Reszka |
Advanced Drug Delivery Reviews | 2001 |
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Potential protective role of angiotensin-converting enzyme inhibitors captopril and enalapril against adriamycin-induced acute cardiac and hepatic toxicity in rats
MA El-Aziz, AI Othman, M Amer, MA El-Missiry |
Journal of Applied Toxicology | 2001 |
|
Overexpression of MnSOD Protects Murine Fibrosarcoma Cells (FSa-II) from Apoptosis and Promotes a Differentiation Program upon Treatment with 5-Azacytidine: Involvement of MAPK and NFκB Pathways
Y Zhao, KK Kiningham, SM Lin, DK st. Clair |
Antioxidants & Redox Signaling | 2001 |
|
TPA-Activated Transcription of the HumanMnSODGene: Role of Transcription Factors SP-1 and Egr-1
S Porntadavity, Y Xu, K Kiningham, VM Rangnekar, V Prachayasitikul, DK st. Clair |
DNA and Cell Biology | 2001 |
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Strain-dependent high-level expression of a transgene for manganese superoxide dismutase is associated with growth retardation and decreased fertility
I Raineri, EJ Carlson, R Gacayan, S Carra, TD Oberley, TT Huang, CJ Epstein |
Free radical biology & medicine | 2001 |
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Nuclear factor kappaB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2
KK Kiningham, Y Xu, C Daosukho, B Popova, DK st Clair |
Biochemical Journal | 2001 |
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Anthracycline-Induced Cardiac Injury Using a Cardiac Cell Line: Potential for Gene Therapy Studies
T L'Ecuyer, MS Horenstein, R Thomas, RV Heide |
Molecular Genetics and Metabolism | 2001 |
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Attenuation of the acute adriamycin-induced cardiac and hepatic oxidative toxicity by N-(2-mercaptopropionyl) glycine in rats
MA El-Missiry, AI Othman, MA Amer, MA El-Aziz |
Free Radical Research | 2001 |
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A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes
T Suzuki, T Miyauchi |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2001 |
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Altered antioxidant defence in a mouse adriamycin model of glomerulosclerosis
A Deman, B Ceyssens, M Pauwels, J Zhang, KV Houte, D Verbeelen, CV Branden |
Nephrology Dialysis Transplantation | 2001 |
|
Recent developments in gene therapy for cardiac disease
S Wattanapitayakul |
Biomedecine & Pharmacotherapy | 2000 |
|
Oxidative stress in congestive heart failure
PK Singal, N Khaper, F Farahmand, A Belló-Klein |
Current Cardiology Reports | 2000 |
|
Morphologic assessment of oxidative damage: A review
TD Oberley, TA Zainal |
AGE | 2000 |
|
Antioxidant and oxidative status in tissues of manganese superoxide dismutase transgenic mice
W Ibrahim, US Lee, HC Yen, DK st. Clair, CK Chow |
Free radical biology & medicine | 2000 |
|
Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase
WF Maragos, R Jakel, D Chesnut, CB Pocernich, DA Butterfield, DS Clair, WA Cass |
Brain Research | 2000 |
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Mitochondria, oxygen free radicals, disease and ageing
S Raha, BH Robinson |
Trends in Biochemical Sciences | 2000 |
|
Decreased Pulmonary Radiation Resistance of Manganese Superoxide Dismutase (MnSOD)-Deficient Mice is Corrected by Human Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Intratracheal Gene Therapy
MW Epperly, CJ Epstein, EL Travis, JS Greenberger |
Radiation Research | 2000 |
|
Molecular Basis of Anthracycline-Induced Cardiotoxicity and Its Prevention
MS Horenstein, RS Heide, TJ L'Ecuyer |
Molecular Genetics and Metabolism | 2000 |
|
Oxidative stress and cardiac disease
DJ Lefer, DN Granger |
The American Journal of Medicine | 2000 |
|
Bicarbonate exacerbates oxidative injury induced by antitumor antibiotic doxorubicin in cardiomyocytes
EA Konorev, H Zhang, J Joseph, MC Kennedy, B Kalyanaraman |
American journal of physiology. Heart and circulatory physiology | 2000 |
|
Doxorubicin Represses CARP Gene Transcription Through the Generation of Oxidative Stress in Neonatal Rat Cardiac Myocytes: Possible Role of Serine/Threonine Kinase-dependent Pathways
Y Aihara, M Kurabayashi, T Tanaka, S Takeda, K Tomaru, K Sekiguchi, Y Ohyama, R Nagai |
Journal of Molecular and Cellular Cardiology | 2000 |
|
Progressive cardiac dysfunction in adriamycin-induced cardiomyopathy rats
K Teraoka, M Hirano, K Yamaguchi, A Yamashina |
European Journal of Heart Failure | 2000 |
|
Apoptosis in Rat Cardiac Myocytes Induced by Fas Ligand: Priming for Fas-mediated Apoptosis with Doxorubicin
M Yamaoka, S Yamaguchi, T Suzuki, M Okuyama, J Nitobe, N Nakamura, Y Mitsui, H Tomoike |
Journal of Molecular and Cellular Cardiology | 2000 |
|
The protective effect of glutathione administration on adriamycin-induced acute cardiac toxicity in rats
HE Mohamed, SE El-Swefy, HH Hagar |
Pharmacological Research | 2000 |
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Inducible Expression of Manganese Superoxide Dismutase by Phorbol 12-Myristate 13-Acetate Is Mediated by Sp1 in Endothelial Cells
T Tanaka, M Kurabayashi, Y Aihara, Y Ohyama, R Nagai |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
|
Effects of combined irradiation and doxorubicin treatment on cardiac function and antioxidant defenses in the rat
F Dalloz, P Maingon, Y Cottin, F Briot, JC Horiot, L Rochette |
Free radical biology & medicine | 1999 |
|
Myocardial protection with endogenous overexpression of manganese superoxide dismutase
K Suzuki, Y Sawa, H Ichikawa, Y Kaneda, H Matsuda |
The Annals of Thoracic Surgery | 1999 |
|
Adriamycin-induced changes of creatine kinase activity in vivo and in cardiomyocyte culture
SM DeAtley, MY Aksenov, MV Aksenova, B Jordan, JM Carney, DA Butterfield |
Toxicology | 1999 |
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Cardiac Resistance to Adriamycin in Transgenic Mice Expressing a Rat alpha-Cardiac Myosin Heavy Chain/Human Multiple Drug Resistance 1 Fusion Gene
G Dell'Acqua, R Polishchuck, JT Fallon, JW Gordon |
Human Gene Therapy | 1999 |
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An Intronic NF-kappaB Element Is Essential for Induction of the Human Manganese Superoxide Dismutase Gene by Tumor Necrosis Factor-alpha and Interleukin-1beta
Y Xu, KK Kiningham, MN Devalaraja, CC Yeh, H Majima, EJ Kasarskis, DK st. Clair |
DNA and Cell Biology | 1999 |
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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
DA Gewirtz |
Biochemical Pharmacology | 1999 |
|
Manganese Superoxide Dismutase Protects Mitochondrial Complex I against Adriamycin-Induced Cardiomyopathy in Transgenic Mice
HC Yen, TD Oberley, CG Gairola, LI Szweda, DK st. Clair |
Archives of Biochemistry and Biophysics | 1999 |
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Cell-Permeable Superoxide Dismutase and Glutathione Peroxidase Mimetics Afford Superior Protection against Doxorubicin-Induced Cardiotoxicity: The Role of Reactive Oxygen and Nitrogen Intermediates
EA Konorev, MC Kennedy, B Kalyanaraman |
Archives of Biochemistry and Biophysics | 1999 |
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Intratracheal injection of adenovirus containing the human MNSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis
MW Epperly, JA Bray, S Krager, LM Berry, W Gooding, JF Engelhardt, R Zwacka, EL Travis, JS Greenberger |
International journal of radiation oncology, biology, physics | 1999 |
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Enhancement of Cytotoxicity of Hydrogen Peroxide by Hyperthermia in Chinese Hamster Ovary Cells: Role of Antioxidant Defenses
S Lord-Fontaine, DA Averill |
Archives of Biochemistry and Biophysics | 1999 |
|
Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD
AJ Bruce-Keller, JW Geddes, PE Knapp, RW McFall, JN Keller, FW Holtsberg, S Parthasarathy, SM Steiner, MP Mattson |
Journal of Neuroimmunology | 1999 |
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Bioinorganic Catalysis
E Stiefel, R Pilato |
Bioinorganic Catalysis | 1999 |
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Daunorubicin-Induced Apoptosis in Rat Cardiac Myocytes Is Inhibited by Dexrazoxane
DB Sawyer, R Fukazawa, MA Arstall, RA Kelly |
Circulation research | 1999 |
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Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells
Y Xu, A Krishnan, XS Wan, H Majima, CC Yeh, G Ludewig, EJ Kasarskis, DK St.Clair |
Oncogene | 1999 |
|
Role of iron in anthracycline cardiotoxicity: new tunes for an old song?
G Minotti, G Cairo, E Monti |
The FASEB Journal | 1999 |
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Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury
P G Sullivan, A J Bruce-Keller, A G Rabchevsky, S Christakos, D K Clair, M P Mattson, S W Scheff |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 1999 |
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Exacerbation of Damage and Altered NF-κB Activation in Mice Lacking Tumor Necrosis Factor Receptors after Traumatic Brain Injury
Sullivan PG, Bruce-Keller AJ, Rabchevsky AG, Christakos S, Clair DK, Mattson MP, Scheff SW |
Journal of Neuroscience | 1999 |
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Transcriptional Regulation of the 5′ Proximal Promoter of the Human Manganese Superoxide Dismutase Gene
CC Yeh, XS Wan, DK st. Clair |
DNA and Cell Biology | 1998 |
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Manganese Superoxide Dismutase Overexpression Attenuates MPTP Toxicity
P Klivenyi, DS Clair, M Wermer, HC Yen, T Oberley, L Yang, MF Beal |
Neurobiology of Disease | 1998 |
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The nature of antioxidant defense mechanisms: a lesson from transgenic studies
YS Ho, JL Magnenat, M Gargano, J Cao |
Environmental Health Perspectives | 1998 |
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Antioxidant inhibitors for cancer therapy
Q Kong, KO Lillehei |
Medical Hypotheses | 1998 |
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Immunodetection of manganese superoxide dismutase in cultured human retroocular fibroblasts using sera directed against the thyrotropin receptor
HB Burch, S Barnes, EV Nagy, D Sellitti, KD Burman, RS Bahn, S Lahiri |
Journal of Endocrinological Investigation | 1998 |
|
Phagomimetic Action of Antimicrobial Agents
JM Gutteridge, GJ Quinlan, P Kovacic |
Free Radical Research | 1998 |
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Prevention of Mitochondrial Injury by Manganese Superoxide Dismutase Reveals a Primary Mechanism for Alkaline-induced Cell Death
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