JCI - Citations to Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

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Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

L F Hebert Jr, … , A D Baron, D A McClain

L F Hebert Jr, … , A D Baron, D A McClain

Published August 15, 1996
Citation Information: J Clin Invest. 1996;98(4):930-936. https://doi.org/10.1172/JCI118876.

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The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code" DC Love, JA Hanover	Science signaling	2005
Turnover and characterization of UDP-N-acetylglucosaminyl transferase in a stably transfected HeLa cell line S Marshall, R Okuyama, JM Rumberger	Biochemical and Biophysical Research Communications	2005
Partial characterisation of the human GFAT promoter: Effect of single nucleotide polymorphisms on promoter function D Burt, K Brodbeck, HU Häring, ED Schleicher, C Weigert	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2005
Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid DA McClain, M Hazel, G Parker, RC Cooksey	American journal of physiology. Endocrinology and metabolism	2005
Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase Y Terauchi, J Matsui, J Kamon, T Yamauchi, N Kubota, K Komeda, S Aizawa, Y Akanuma, M Tomita, T Kadowaki	Diabetes	2004
The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes C Bouché, S Serdy, CR Kahn, AB Goldfine	Endocrine reviews	2004
Activation of the Hexosamine Signaling Pathway in Adipose Tissue Results in Decreased Serum Adiponectin and Skeletal Muscle Insulin Resistance M Hazel, RC Cooksey, D Jones, G Parker, JL Neidigh, B Witherbee, EA Gulve, DA McClain	Endocrinology	2004
Chemistry and Biochemistry of Type 2 Diabetes SA Ross, EA Gulve, M Wang	Chemical Reviews	2004
Hexosamines Are Unlikely to Function as a Nutrient-Sensor in 3T3-L1 Adipocytes: A Comparison of UDP-Hexosamine Levels after Increased Glucose Flux and Glucosamine Treatment RR Bosch, MJ Pouwels, PN Span, AJ Olthaar, CJ Tack, AR Hermus, CG Sweep	Endocrine	2004
Glucosamine-induced insulin resistance in L6 muscle cells CJ Bailey, SL Turner	Diabetes, Obesity and Metabolism	2004
Molecular screening of the human glutamine–fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy SC Elbein, H Zheng, Y Jia, W Chu, JJ Cooper, T Hale, Z Zhang	Molecular Genetics and Metabolism	2004
A simple and sensitive method for glutamine:fructose-6-phosphate amidotransferase assay F Ye, H Maegawa, K Morino, A Kashiwagi, R Kikkawa, M Xie, Z Shen	Journal of Biochemical and Biophysical Methods	2004
Nutrient sensing and metabolic decisions JE Lindsley, J Rutter	Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology	2004
Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle Edward B Arias, Junghoon Kim, Gregory D Cartee	Diabetes	2004
Hyperglycemia and Inhibition of Glycogen Synthase in Streptozotocin-treated Mice: ROLE OF O -LINKED N -ACETYLGLUCOSAMINE G Parker, R Taylor, D Jones, D McClain	The Journal of biological chemistry	2004
Hexosamines and TGF-β 1 use similar signaling pathways to mediate matrix protein synthesis in mesangial cells LP Singh, K Green, M Alexander, S Bassly, ED Crook	American journal of physiology. Renal physiology	2004
Involvement of gangliosides in glucosamine-induced proliferation decrease of retinal pericytes E Masson, N Wiernsperger, M Lagarde, SE Bawab	Glycobiology	2004
Cardiovascular Pharmacogenetics MR Wilkins		2004
Increased O ‐glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic β‐cells C D'Alessandris, F Andreozzi, M Federici, M Cardellini, A Brunetti, M Ranalli, SD Guerra, D Lauro, SD Prato, P Marchetti, R Lauro, G Sesti	The FASEB Journal	2004
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase DC Love, J Kochran, RL Cathey, SH Shin, JA Hanover	Journal of cell science	2003
International Textbook of Diabetes Mellitus RA DeFronzo, L Mandarino, E Ferrannini	International Textbook of Diabetes Mellitus	2003
The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle JR Zierath, Y Kawano	Best Practice & Research Clinical Endocrinology & Metabolism	2003
The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 β-cells Y Gao, JI Miyazaki, GW Hart	Archives of Biochemistry and Biophysics	2003
Overexpression of the complementary DNA for human glutamine:fructose-6-phosphate amidotransferase in mesangial cells enhances glucose-induced fibronectin synthesis and transcription factor cyclic adenosine monophosphate-responsive element binding phosphorylation Lalit P Singh, Michelle Alexander, Kenneith Greene, Errol D Crook	Journal of Investigative Medicine	2003
Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase Cora Weigert, Karsten Klopfer, Christiana Kausch, Katrin Brodbeck, Michael Stumvoll, Hans U Häring, Erwin D Schleicher	Diabetes	2003
N -acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress CA Haber, TK Lam, Z Yu, N Gupta, T Goh, E Bogdanovic, A Giacca, IG Fantus	American journal of physiology. Endocrinology and metabolism	2003
Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle DH Han, MM Chen, JO Holloszy	American journal of physiology. Endocrinology and metabolism	2003
Progress in Drug Research H Wu, EJ Lien, LL Lien, RM Schultz, VJ Ram, E Domingo, P Spence, SP Gupta, SP Bhat, EC Villarreal, E Jucker		2003
Pharmacological Agents That Directly Modulate Insulin Secretion ME Doyle, JM Egan	Pharmacological reviews	2003
Plasma Leptin and Exercise: Recent Findings MW Hulver, JA Houmard	Sports Medicine	2003
Exploring Levels of Hexosamine Biosynthesis Pathway Intermediates and Protein Kinase C Isoforms in Muscle and Fat Tissue of Zucker Diabetic Fatty Rats RR Bosch, SW Janssen, PN Span, AJ Olthaar, SE van Emst-de Vries, PH Willems, GJ Martens, AR Hermus, CG Sweep	Endocrine	2003
Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia DA McClain, WA Lubas, RC Cooksey, M Hazel, GJ Parker, DC Love, JA Hanover	Proceedings of the National Academy of Sciences	2002
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes JL Evans, ID Goldfine, BA Maddux, GM Grodsky	Endocrine reviews	2002
Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway I Gabriely, XM Yang, JA Cases, XH Ma, L Rossetti, N Barzilai	Atherosclerosis	2002
The hexosamine signaling pathway: a new road to drug discovery S Marshall	Current Opinion in Endocrinology & Diabetes	2002
Transgenic Mice Overexpressing the Rate-Limiting Enzyme for Hexosamine Synthesis in Skeletal Muscle or Adipose Tissue Exhibit Total Body Insulin Resistance RC Cooksey, DO McCLAIN	Annals of the New York Academy of Sciences	2002
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes K Vosseller, L Wells, MD Lane, GW Hart	Proceedings of the National Academy of Sciences	2002
Hexosamines as mediators of nutrient sensing and regulation in diabetes DA McClain	Journal of Diabetes and its Complications	2002
Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds RG Spiro	Glycobiology	2002
Glucosamine-6-phosphate synthase—the multi-facets enzyme S Milewski	Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology	2002
GLUT2 is a high affinity glucosamine transporter M Uldry, M Ibberson, M Hosokawa, B Thorens	FEBS Letters	2002
Insulin Resistance and Insulin Resistance Syndrome A Cincotta	Insulin Resistance and Insulin Resistance Syndrome	2002
Intracellular glycosylation and development N O'Donnell	Biochimica et Biophysica Acta (BBA) - General Subjects	2002
Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor B- Dependent Promoter Activation LR James, D Tang, A Ingram, H Ly, K Thai, L Cai, JW Scholey	Diabetes	2002
Enhanced O -GlcNAc protein modification is associated with insulin resistance in GLUT1-overexpressing muscles MG Buse, KA Robinson, BA Marshall, RC Hresko, MM Mueckler	American journal of physiology. Endocrinology and metabolism	2002
Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression H Kaneto, G Xu, N Fujii, S Kim, S Bonner-Weir, GC Weir	The Journal of biological chemistry	2002
Kinetic Characterization of Human Glutamine-fructose-6-phosphate Amidotransferase I: POTENT FEEDBACK INHIBITION BY GLUCOSAMINE 6-PHOSPHATE KO Broschat, C Gorka, JD Page, CL Martin-Berger, MS Davies, H Huang, EA Gulve, WJ Salsgiver, TP Kasten	The Journal of biological chemistry	2002
Drug Discovery and Evaluation HG Vogel, WH Vogel, BA Schölkens, J Sandow, G Müller, WF Vogel		2002
Understanding adipose tissue development from transgenic animal models P Valet, G Tavernier, I Castan-Laurell, JS Saulnier-Blache, D Langin	Journal of lipid research	2002
Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via phosphatidylinositol 3-kinase pathway in rat aortic smooth muscle cells A Sato, T Sasaoka, K Yamazaki, N Nakamura, R Temaru, M Ishiki, M Takata, M Kishida, T Wada, H Ishihara	Atherosclerosis	2001
Hexosamines as mediators of nutrient sensing: relevance to obesity, insulin resistance, and diabetes DA McClain	Current Opinion in Endocrinology & Diabetes	2001
Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide synthesis G Wu, TE Haynes, H Li, W Yan, CJ Meininger	Biochemical Journal	2001
Glucose-induced insulin resistance of phosphatidylinositol 3′-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway LP Singh, D Gennerette, S Simmons, ED Crook	Journal of Diabetes and its Complications	2001
Hyperglycemia and the O-GlcNAc Transferase in Rat Aortic Smooth Muscle Cells: Elevated Expression and Altered Patterns of O-GlcNAcylation Y Akimoto, LK Kreppel, H Hirano, GW Hart	Archives of Biochemistry and Biophysics	2001
A Novel Variant of Glutamine: Fructose-6-Phosphate Amidotransferase-1 (GFAT1) mRNA Is Selectively Expressed in Striated Muscle JE DeHaven, KA Robinson, BA Nelson, MG Buse	Diabetes	2001
Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats CS Choi, FN Lee, JH Youn	Diabetes	2001
Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: The Involvement of Protein Kinases A and C LP Singh, J Andy, V Anyamale, K Greene, M Alexander, ED Crook	Diabetes	2001
Overfeeding rapidly induces leptin and insulin resistance J Wang, S Obici, K Morgan, N Barzilai, Z Feng, L Rossetti	Diabetes	2001
Insulin Control of Glycogen Metabolism in Knockout Mice Lacking the Muscle-Specific Protein Phosphatase PP1G/RGL Y Suzuki, C Lanner, JH Kim, PG Vilardo, H Zhang, J Yang, LD Cooper, M Steele, A Kennedy, CB Bock, A Scrimgeour, JC Lawrence, AA DePaoli-Roach	Molecular and cellular biology	2001
Development of Glucose-induced Insulin Resistance in Muscle Requires Protein Synthesis K Kawanaka, DH Han, J Gao, LA Nolte, JO Holloszy	The Journal of biological chemistry	2001
Dynamic O -Glycosylation of Nuclear and Cytosolic Proteins: CLONING AND CHARACTERIZATION OF A NEUTRAL, CYTOSOLIC β- N -ACETYLGLUCOSAMINIDASE FROM HUMAN BRAIN Y Gao, L Wells, FI Comer, GJ Parker, GW Hart	The Journal of biological chemistry	2001
Angiotensin II activates the GFAT promoter in mesangial cells LR James, A Ingram, H Ly, K Thai, L Cai, JW Scholey	American journal of physiology. Renal physiology	2001
Genetics of Diabetes Mellitus WL Lowe		2001
Assay for Hexosamine Pathway Intermediates (Uridine Diphosphate-N-Acetyl Amino Sugars) in Small Samples of Human Muscle Tissue PN Span, MJ Pouwels, AJ Olthaar, RR Bosch, AR Hermus, CG Sweep	Clinical chemistry	2001
Regulation of Glucose Transporters - Implications for Insulin Resistance States A Tirosh, A Rudich, N Bashan	Journal of Pediatric Endocrinology and Metabolism	2000
Simultaneous, quantitative analysis of UDP-N-acetylglucosamine, UDP-N-acetylgalactosamine, UDP-glucose and UDP-galactose in human peripheral blood cells, muscle biopsies and cultured mesangial cells by capillary zone electrophoresis R Lehmann, M Huber, A Beck, T Schindera, T Rinkler, B Houdali, C Weigert, HU Häring, W Voelter, ED Schleicher	Electrophoresis	2000
Glucosamine Inhibits Inducible Nitric Oxide Synthesis CJ Meininger, KA Kelly, H Li, TE Haynes, G Wu	Biochemical and Biophysical Research Communications	2000
Development and Comparison of Two 3T3-L1 Adipocyte Models of Insulin Resistance: Increased Glucose Flux vs Glucosamine Treatment SA Ross, X Chen, HR Hope, S Sun, EG McMahon, K Broschat, EA Gulve	Biochemical and Biophysical Research Communications	2000
Cloning and characterization of mouse glutamine:fructose-6-phosphate amidotransferase 2 gene promoter K Yamazaki, Y Mizui, T Oki, M Okada, I Tanaka	Gene	2000
Purification and Characterization of Glutamine:Fructose 6-Phosphate Amidotransferase from Rat Liver QK Huynh, EA Gulve, T Dian	Archives of Biochemistry and Biophysics	2000
Streptozotocin-Induced β-Cell Death Is Independent of Its Inhibition of O-GlcNAcase in Pancreatic Min6 Cells Y Gao, GJ Parker, GW Hart	Archives of Biochemistry and Biophysics	2000
Structure of O-Linked GlcNAc Transferase: Mediator of Glycan-Dependent Signaling MD Roos, JA Hanover	Biochemical and Biophysical Research Communications	2000
Application of liquid chromatography–nuclear magnetic resonance spectroscopy to the identification of natural products SC Bobzin, S Yang, TP Kasten	Journal of Chromatography B Biomedical Sciences and Applications	2000
Effects of Insulin on Prenylation as a Mechanism of Potentially Detrimental Influence of Hyperinsulinemia 1 B Draznin, P Miles, Y Kruszynska, J Olefsky, J Friedman, I Golovchenko, R Stjernholm, K Wall, M Reitman, D Accili, R Cooksey, D McClain, M Goalstone	Endocrinology	2000
Transcriptional Regulation of Transforming Growth Factor β1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway MC Daniels, DA McClain, ED Crook	The American Journal of the Medical Sciences	2000
Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level AH Hasty, H Shimano, N Yahagi, M Amemiya-Kudo, S Perrey, T Yoshikawa, J Osuga, H Okazaki, Y Tamura, Y Iizuka, F Shionoiri, K Ohashi, K Harada, T Gotoda, R Nagai, S Ishibashi, N Yamada	The Journal of biological chemistry	2000
Lower calorie intake enhances muscle insulin action and reduces hexosamine levels AC Gazdag, TJ Wetter, RT Davidson, KA Robinson, MG Buse, AJ Yee, LP Turcotte, GD Cartee	American Journal of Physiology - Regulatory, Integrative and Comparative Physiology	2000
Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinases A and C LP Singh, ED Crook	American journal of physiology. Renal physiology	2000
Glucosamine-induced insulin resistance in 3T3-L1 adipocytes E Heart, WS Choi, CK Sung	American journal of physiology. Endocrinology and metabolism	2000
O -Glycosylation of Nuclear and Cytosolic Proteins: DYNAMIC INTERPLAY BETWEEN O- GlcNAc AND O- PHOSPHATE FI Comer, GW Hart	The Journal of biological chemistry	2000
Functional Expression of O -linked GlcNAc Transferase: DOMAIN STRUCTURE AND SUBSTRATE SPECIFICITY WA Lubas, JA Hanover	The Journal of biological chemistry	2000
Overexpression of GFAT activates PAI-1 promoter in mesangial cells LR James, IG Fantus, H Goldberg, H Ly, JW Scholey	American journal of physiology. Renal physiology	2000
Phosphorylation of Human Glutamine:Fructose-6-phosphate Amidotransferase by cAMP-dependent Protein Kinase at Serine 205 Blocks the Enzyme Activity Q Chang, K Su, JR Baker, X Yang, AJ Paterson, JE Kudlow	The Journal of biological chemistry	2000
Transcriptional Regulation of Transforming Growth Factor ??1 by Glucose: Investigation into the Role of the Hexosamine Biosynthesis Pathway: MC Daniels, DA McClain, ED Crook	The American Journal of the Medical Sciences	2000
Obesity: Pathology and Therapy DH Lockwood, TC Heffner		2000
Overexpression of Glutamine:Fructose-6-Phosphate Amidotransferase in Rat-1 Fibroblasts Enhances Glucose-Mediated Glycogen Accumulation via Suppression of Glycogen Phosphorylase Activity* ED Crook, G Crenshaw, G Veerababu, LP Singh	Endocrinology	2000
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance A Virkamäki, K Ueki, CR Kahn	Journal of Clinical Investigation	1999
Nutrient Modulation of Cellular Insulin Action ME Patti	Annals of the New York Academy of Sciences	1999
cDNA Cloning and Mapping of a Novel Subtype of Glutamine:fructose-6-phosphate Amidotransferase (GFAT2) in Human and Mouse T Oki, K Yamazaki, J Kuromitsu, M Okada, I Tanaka	Genomics	1999
Glutamine: Fructose-6-phosphate amidotransferase activity and gene expression are regulated in a tissue-specific fashion in pregnant rats H Yki-Järvinen, T Nyman, E Rissanen, M Leino, S Hämäläinen, A Virkamäki, SH Mouzon	Life Sciences	1999
Modulation of CCAAT/enhancer-binding protein-alpha gene expression by metabolic signals in rodent adipocytes Y Wang, W Lee-Kwon, JL Martindale, L Adams, P Heller, JM Egan, M Bernier	Endocrinology	1999
Dose-response relationship of insulin to glucose fluxes in the awake and unrestrained mouse HQ Shen, JS Zhu, AD Baron	Metabolism	1999
Decreased hexosamine biosynthesis in GH-deficient dwarf rat muscle. Reversal with GH, but not IGF-I, therapy KA Robinson, SM Willi, S Bingel, MG Buse	American journal of physiology. Endocrinology and metabolism	1999
The Inhibition of Capacitative Calcium Entry Due to ATP Depletion but Not Due to Glucosamine Is Reversed by Staurosporine S Vemuri, RB Marchase	The Journal of biological chemistry	1999
Mechanism of Hexosamine-Induced Insulin Resistance in Transgenic Mice Overexpressing Glutamine:Fructose-6-Phosphate Amidotransferase: Decreased Glucose Transporter GLUT4 Translocation and Reversal by Treatment with Thiazolidinedione* RC Cooksey, LF Hebert, JH Zhu, P Wofford, WT Garvey, DA McClain	Endocrinology	1999
Glucosamine Regulation of Glucose Metabolism in Cultured Human Skeletal Muscle Cells: Divergent Effects on Glucose Transport/Phosphorylation and Glycogen Synthase in Non-Diabetic and Type 2 Diabetic Subjects1 TP Ciaraldi, L Carter, S Nikoulina, S Mudaliar, DA McClain, RR Henry	Endocrinology	1999
Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy G Pugliese, F Pricci, G Romeo, G Leto, L Amadio, C Iacobini, UD Mario	Journal of Endocrinological Investigation	1999
TRANSGENIC MICE IN THE ANALYSIS OF METABOLIC REGULATION F Bosch, A Pujol, A Valera	Annual Review of Nutrition	1998
Availability of specific sugars for glycoconjugate biosynthesis: A need for further investigations in man A Martin, C Rambal, V Berger, S Perier, P Louisot	Biochimie	1998
Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo H Yki-Järvinen, A Virkamäki, MC Daniels, D McClain, WK Gottschalk	Metabolism	1998
Glucosamine-induced Insulin Resistance in 3T3-L1 Adipocytes Is Caused by Depletion of Intracellular ATP RC Hresko, H Heimberg, MM Chi, M Mueckler	The Journal of biological chemistry	1998
Role of the glucosamine pathway in fat-induced insulin resistance M Hawkins, N Barzilai, R Liu, M Hu, W Chen, L Rossetti	Journal of Clinical Investigation	1997
Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells H Chen, BL Ing, KA Robinson, AC Feagin, MG Buse, MJ Quon	Molecular and Cellular Endocrinology	1997
O -Linked GlcNAc Transferase Is a Conserved Nucleocytoplasmic Protein Containing Tetratricopeptide Repeats WA Lubas, DW Frank, M Krause, JA Hanover	The Journal of biological chemistry	1997
Clinical Research in Diabetes and Obesity B Draznin, R Rizza		1997

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