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Research Article Free access | 10.1172/JCI118869

The Gln-Arg191 polymorphism of the human paraoxonase gene (HUMPONA) is not associated with the risk of coronary artery disease in Finns.

M Antikainen, S Murtomäki, M Syvänne, R Pahlman, E Tahvanainen, M Jauhiainen, M H Frick, and C Ehnholm

National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

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National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

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National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

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National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

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National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

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National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

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National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

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National Public Health Institute, Department of Biochemistry, Helsinki, Finland.

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Published August 15, 1996 - More info

Published in Volume 98, Issue 4 on August 15, 1996
J Clin Invest. 1996;98(4):883–885. https://doi.org/10.1172/JCI118869.
© 1996 The American Society for Clinical Investigation
Published August 15, 1996 - Version history
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Abstract

The human paraoxonase gene (HUMPONA) is codominantly expressed as alleles A and G. The A allele codes for glutamine (A genotype) and the G allele for arginine (B genotype) at position 191 of the paraoxonase enzyme. This genetic polymorphism has been suggested to be associated with the predisposition to coronary artery disease (CAD). We investigated the frequency of paraoxonase A and G alleles in 380 well-characterized CAD patients and in 169 controls. The most common genotype in both the patients with CAD (211/380) and in healthy Finnish individuals (87/169) was AA (Gln/Gln). The heterozygous AM (Gln/Arg) genotype was present in 140 of the patients and in 75 controls. The frequency of the A allele was 0.74 in both patients and controls. The genotype distribution between the two groups did not differ (P = 0.12, chi2 test). The genotype distributions were also similar to those reported earlier in other caucasoid populations. In conclusion, we found no association between the Gln-Arg 191 polymorphism of the human paraoxonase gene and coronary artery disease in Finns.

Version history
  • Version 1 (August 15, 1996): No description
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