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Citations to this article

The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.
S Devaraj, … , D Li, I Jialal
S Devaraj, … , D Li, I Jialal
Published August 1, 1996
Citation Information: J Clin Invest. 1996;98(3):756-763. https://doi.org/10.1172/JCI118848.
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Research Article Article has an altmetric score of 6

The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium.

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Abstract

Low levels of alpha tocopherol are related to a higher incidence of cardiovascular disease and increased intake appears to afford protection against cardiovascular disease. In addition to decreasing LDL oxidation, alpha tocopherol may exert intracellular effects on cells crucial in atherogenesis, such as monocytes. Hence, the aim of this study was to test the effect of alpha tocopherol supplementation on monocyte function relevant to atherogenesis. Monocyte function was assessed in 21 healthy subjects at baseline, after 8 wk of supplementation with d-alpha tocopherol (1,200 IU/d) and after a 6-wk washout phase. The release of reactive oxygen species (superoxide anion, hydrogen peroxide), lipid oxidation, release of the potentially atherogenic cytokine, interleukin 1 beta, and monocyte-endothelial adhesion were studied in the resting state and after activation of the monocytes with lipopolysaccharide at 0, 8, and 14 wk. There was a 2.5-fold increase in plasma lipid-standardized and monocyte alpha tocopherol levels in the supplemented phase. After alpha tocopherol supplementation, there were significant decreases in release of reactive oxygen species, lipid oxidation, IL-1 beta secretion, and monocyte-endothelial cell adhesion, both in resting and activated cells compared with baseline and washout phases. Studies with the protein kinase C inhibitor, Calphostin C, suggest that the inhibition of reactive oxygen species release and lipid oxidation is due to an inhibition of protein kinase C activity by alpha tocopherol. Thus, this study provides novel evidence for an intracellular effect of alpha tocopherol in monocytes that is antiatherogenic.

Authors

S Devaraj, D Li, I Jialal

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Citations to this article in year 2004 (15)

Title and authors Publication Year
Anti-atherosclerotic effects of vitamin E ? myth or reality?
A Munteanu, JM Zingg, A Azzi
Journal of Cellular and Molecular Medicine 2004
Vitamin E supplementation suppresses macrophage accumulation and endothelial cell expression of adhesion molecules in the aorta of hypercholesterolemic rabbits
T Koga, P Kwan, L Zubik, C Ameho, D Smith, M Meydani
Atherosclerosis 2004
Vitamin E Modulation of Cardiovascular Disease
M Meydani
Annals of the New York Academy of Sciences 2004
The antiatherogenic potential of oat phenolic compounds
L Liu, L Zubik, FW Collins, M Marko, M Meydani
Atherosclerosis 2004
Vitamin E modulation of C-reactive protein in smokers with acute coronary syndromes
RT Murphy, JB Foley, MT Tome, NT Mulvihill, A Murphy, N McCarroll, P Crean, MJ Walsh
Free radical biology & medicine 2004
Vitamin E-Coated Dialyzer Membranes Downregulate Expression of Monocyte Adhesion and Co-Stimulatory Molecules
MG Betjes, FM Hoekstra, M Klepper, SM Postma, LM Vaessen
Blood Purification 2004
Vitamin E-loaded dialyzer resets PBMC-operated cytokine network in dialysis patients
C Libetta, M Zucchi, E Gori, V Sepe, F Galli, F Meloni, F Milanesi, AD Canton
Kidney International 2004
Glycoxidized low-density lipoprotein regulates the expression of scavenger receptors in THP-1 macrophages
MC Lam, KC Tan, KS Lam
Atherosclerosis 2004
Supplementation with ω3 polyunsaturated fatty acids and all-rac alpha-tocopherol alone and in combination failed to exert an anti-inflammatory effect in human volunteers
S Vega-López, N Kaul, S Devaraj, RY Cai, B German, I Jialal
Metabolism 2004
Anti-inflammatory Effects of α-Tocopherol
U Singh, I Jialal
Annals of the New York Academy of Sciences 2004
Immune cells: free radicals and antioxidants in sepsis
VM Victor, M Rocha, MD la Fuente
International Immunopharmacology 2004
Polystyrene surface coated with vitamin E modulates human granulocyte adhesion and MMP-9 release
F Renò, F Lombardi, M Cannas
Biomolecular Engineering 2004
Plasma C-Reactive Protein Concentrations in Active and Passive Smokers: Influence of Antioxidant Supplementation
G Block, C Jensen, M Dietrich, EP Norkus, M Hudes, L Packer
Journal of the American College of Nutrition 2004
Effect of Aminoethylcysteine Ketimine Decarboxylated Dimer, a Natural Sulfur Compound Present in Human Plasma, on Tert -Butyl Hydroperoxide-induced Oxidative Stress in Human Monocytic U937 Cells
A Macone, RM Matarese, V Gentili, A Antonucci, S Duprè, M Nardini
Free Radical Research 2004
Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-κB
K Asehnoune, D Strassheim, S Mitra, JY Kim, E Abraham
Journal of immunology (Baltimore, Md. : 1950) 2004

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