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Citations to this article

Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.
T Caulin-Glaser, … , R Pardi, J R Bender
T Caulin-Glaser, … , R Pardi, J R Bender
Published July 1, 1996
Citation Information: J Clin Invest. 1996;98(1):36-42. https://doi.org/10.1172/JCI118774.
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Research Article

Effects of 17beta-estradiol on cytokine-induced endothelial cell adhesion molecule expression.

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Abstract

One of the earliest events in atherosclerosis is interaction of circulating mononuclear leukocytes and the endothelium. Endothelial cell (EC) activation by cytokines results in expression of adhesion molecules and production of chemotactic factors, augmenting leukocyte adhesion and recruitment, respectively. The incidence of atherosclerosis in premenopausal women is significantly less than that observed in age-matched males with similar risk profiles. Because estrogen has gene regulatory effects, we investigated whether 17beta-estradiol (E2) can inhibit cytokine-mediated EC adhesion molecule transcriptional activation. Cultured human umbilical vein EC (estrogen receptor-positive) were propagated in gonadal hormone-free medium and were E2-pretreated for 48 h before IL-1 activation. Detected by FACS analysis, E2 strongly (60-80%) inhibited IL-1-mediated membrane E-selectin and vascular cell adhesion molecule-1 induction, and intercellular adhesion molecule-1 hyperinduction. 17alpha-estradiol (an inactive E2 stereoisomer) had no effect. This inhibition correlated with similar reductions in steady state-induced E-selectin mRNA levels, and was abrogated by the E2 antagonist ICI 164,384, demonstrating a specific, estrogen receptor-mediated effect. Nuclear run-offs confirmed suppression at the transcriptional level. The implications of these results for the cardiovascular protective role of estrogen are discussed.

Authors

T Caulin-Glaser, C A Watson, R Pardi, J R Bender

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Altered gene expression in human cells induced by the agricultural chemical Enable
T Mankame, R Hokanson, R Chowdhary, D Busbee
Toxicology and industrial health 2004
Estrogen suppresses IL-1β-mediated induction of COX-2 pathway in rat cerebral blood vessels
JA Ospina, HN Brevig, DN Krause, SP Duckles
American journal of physiology. Heart and circulatory physiology 2004
The atheroprotective effect of 17β-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice
P Gourdy, Z Mallat, C Castano, B Garmy-Susini, JL Gregor, A Tedgui, JF Arnal, F Bayard
Atherosclerosis 2003
Dehydroepiandrosterone, an adrenalandrogen, increases human foam cell formation
MK Ng, S Nakhla, A Baoutina, W Jessup, DJ Handelsman, DS Celermajer
Journal of the American College of Cardiology 2003
Soy isoflavones prevent ovariectomy-induced atherosclerotic lesions in Golden Syrian hamster model of postmenopausal hyperlipidemia
EA Lucas, SA Lightfoot, LJ Hammond, L Devareddy, DA Khalil, BP Daggy, DY Soung, BH Arjmandi
Menopause 2003
Steroid Receptors in the Uterus: Implications in Endometriosis
P Moutsatsou, CE Sekeris
Annals of the New York Academy of Sciences 2003
ER-α variants and the cardiovascular effects of hormone replacement therapy
DM Herrington, TD Howard
Pharmacogenomics 2003
ISOLATION OF MURINE AORTIC ENDOTHELIAL CELLS IN CULTURE AND THE EFFECTS OF SEX STEROIDS ON THEIR GROWTH
DW Lincoln, AM Larsen, PG Phillips, K Bove
In Vitro Cellular & Developmental Biology - Animal 2003
The role of estrogen in cardiovascular disease
L Baker, KK Meldrum, M Wang, R Sankula, R Vanam, A Raiesdana, B Tsai, K Hile, JW Brown, DR Meldrum
Journal of Surgical Research 2003
17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells
Daigo Sumi, Toshio Hayashi, Hisako Matsui-Hirai, Aaron T Jacobs, Louis J Ignarro, Akihisa Iguchi
Biochimica et Biophysica Acta 2003
Effects of estrogen on the vascular system
RC Tostes, D Nigro, ZB Fortes, MH Carvalho
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2003
Association between Gly241Arg ICAM-1 gene polymorphism and serum sICAM-1 concentration in the Stanislas cohort
A Ponthieux, D Lambert, B Herbeth, S Droesch, M Pfister, S Visvikis
European Journal of Human Genetics 2003
Effect of estradiol administration on splanchnic perfusion after trauma???hemorrhage and sepsis:
Y Yokoyama, MG Schwacha, KI Bland, IH Chaudry
Current Opinion in Critical Care 2003
Effects of tibolone on cell adhesion molecules in postmenopausal women:
C Egarter, M Sator, J Huber
Menopause (New York, N.Y.) 2003
Age- and Sex-related Reference Values for Serum Adhesion Molecule Concentrations in Healthy Individuals: Intercellular Adhesion Molecule-1 and E-, P-, and L-Selectin
A Ponthieux, B Herbeth, S Droesch, D Lambert, S Visvikis
Clinical chemistry 2003
Isolation of murine aortic endothelial cells in culture and the effects of sex steroids on their growth
DW Lincoln, AM Larsen, PG Phillips, K Bove
In vitro cellular & developmental biology. Animal 2003
Effects of continuous combined hormone replacement therapy on inflammation in hypertensive and/or overweight postmenopausal women
KK Koh, JY Ahn, DK Jin, BK Yoon, HS Kim, DS Kim, MS Shin, JW Son, IS Choi, EK Shin
Arteriosclerosis, thrombosis, and vascular biology 2002
The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptor-alpha
MR Adams, DL Golden, TC Register, MS Anthony, JB Hodgin, N Maeda, JK Williams
Arteriosclerosis, thrombosis, and vascular biology 2002
Minireview: Estrogen and Mouse Models of Atherosclerosis
JB Hodgin, N Maeda
Endocrinology 2002
Effects of transdermal hormone replacement therapy on levels of soluble P- and E-selectin in postmenopausal healthy women
A Farzati, K Esposito, N Colacurci, F Fornaro, V Chiantera, B Farzati
Fertility and Sterility 2002
Estrogen inhibits the initiation of fatty streaks throughout the vasculature but does not inhibit intra-plaque hemorrhage and the progression of established lesions in apolipoprotein E deficient mice
ME Rosenfeld, K Kauser, B Martin-McNulty, P Polinsky, SM Schwartz, GM Rubanyi
Atherosclerosis 2002
Estrogens and the Vascular Endothelium
MC Cid, HW Schnaper, HK Kleinman
Annals of the New York Academy of Sciences 2002
Androgens and Estrogens Modulate the Immune and Inflammatory Responses in Rheumatoid Arthritis
M Cutolo, B Seriolo, B Villaggio, C Pizzorni, C Craviotto, A Sulli
Annals of the New York Academy of Sciences 2002
Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis
TK Mukherjee, H Dinh, G Chaudhuri, L Nathan
Proceedings of the National Academy of Sciences 2002
The adhesion molecule ICAM-1 and its regulation in relation with the blood–brain barrier
JB Dietrich
Journal of Neuroimmunology 2002
17β-Estradiol inhibits cytokine induction of the human E-selectin promoter
CM Tyree, A Zou, EA Allegretto
The Journal of Steroid Biochemistry and Molecular Biology 2002
Effects of testosterone and 17-β-estradiol on TNF-α-induced E-selectin and VCAM-1 expression in endothelial cells
X Zhang, LY Wang, TY Jiang, HP Zhang, Y Dou, JH Zhao, H Zhao, ZD Qiao, JT Qiao
Life Sciences 2002
17β-estradiol inhibits the adhesion of leukocytes in TNF-α stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion, but not its transcription
E Rodrı́guez, R López, A Paez, F Massó, LF Montaño
Life Sciences 2002
Effects of Estrogen, Progesterone, and Combination Exposure on Interleukin-1β-Induced Expression of VCAM-1, ICAM-1, PECAM, and E-Selectin by Human Female Iliac Artery Endothelial Cells
KT Piercy, RL Donnell, SS Kirkpatrick, CH Timaran, SL Stevens, MB Freeman, MH Goldman
Journal of Surgical Research 2002
Estradiol reduces basal and cytokine induced monocyte adhesion to endothelial cells
TS Mikkola, RW St.Clair
Maturitas 2002
Lack of stimulatory effect of dienogest on the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by endothelial cell as compared with other synthetic progestins
H Tatsumi
Maturitas 2002
Rapid vascular cell responses to estrogen and membrane receptors
MP Haynes, L Li, KS Russell, JR Bender
Vascular Pharmacology 2002
Estrogen and vascular function
RE White
Vascular Pharmacology 2002
Update on cardiovascular disease in post-menopausal women
GI Gorodeski
Best Practice & Research Clinical Obstetrics & Gynaecology 2002
Reproductive hormones and cardiovascular disease
JD Wagner, JR Kaplan, RT Burkman
Obstetrics and Gynecology Clinics of North America 2002
Estrogen and apoptosis in atherosclerosis
M Barton, MM Kockx
International Congress Series 2002
Sex steroids and the immune system
E Seli, A Arici
Immunology and Allergy Clinics of North America 2002
Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells
S Ling, A Dai, MR Williams, K Myles, RJ Dilley, PA Komesaroff, K Sudhir
Endocrinology 2002
The inhibitory effect of soy protein isolate on atherosclerosis in mice does not require the presence of LDL receptors or alteration of plasma lipoproteins
MR Adams, DL Golden, MS Anthony, TC Register, JK Williams
The Journal of nutrition 2002
Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
A Louissaint, S Rao, C Leventhal, SA Goldman
Neuron 2002
Estrogen replacement therapy and cardioprotection: mechanisms and controversies
MT Subbiah
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2002
Acute effects of 17β-estradiol on femoral veins from adult gonadally intact and ovariectomized female pigs
MP Bracamonte, M Jayachandran, KS Rud, VM Miller
American journal of physiology. Heart and circulatory physiology 2002
Modulatory effects of estrogen in two murine models of experimental colitis
EF Verdú, Y Deng, P Bercik, SM Collins
AJP Gastrointestinal and Liver Physiology 2002
Time- and dose-dependent differential upregulation of three genes by 17β-estradiol in endothelial cells
AC Villablanca, KA Lewis, JC Rutledge
Journal of applied physiology 2002
Estrogen inhibits NF??B-dependent inflammationin brain endothelium without interfering withI??B degradation:
E Galea, R Santizo, DL Feinstein, P Adamsom, J Greenwood, HM Koenig, DA Pelligrino
NeuroReport 2002
Estrogen Receptor-α Mediates the Protective Effects of Estrogen Against Vascular Injury
G Pare, A Krust, RH Karas, S Dupont, M Aronovitz, P Chambon, ME Mendelsohn
Circulation research 2002
Estrogen Causes Dynamic Alterations in Endothelial Estrogen Receptor Expression
CE Ihionkhan, KL Chambliss, LL Gibson, LD Hahner, ME Mendelsohn, PW Shaul
Circulation research 2002
Estrogens Inhibit Angiotensin II–Induced Leukocyte–Endothelial Cell Interactions In Vivo via Rapid Endothelial Nitric Oxide Synthase and Cyclooxygenase Activation
A Álvarez, C Hermenegildo, AC Issekutz, JV Esplugues, MJ Sanz
Circulation research 2002
Exercise-Induced Muscle Damage and the Potential Protective Role of Estrogen:
B Kendall, R Eston
Sports Medicine 2002
Estrogen receptor alpha is a major mediator of the atheroprotective effect of 17beta-estradiol in Apoe-/- mice
Jeffrey B. Hodgin, John H. Krege, Robert L. Reddick, Kenneth S. Korach, Oliver Smithies, Nobuyo Maeda
Journal of Clinical Investigation 2001
Inability of plasma high-density lipoproteins to inhibit cell adhesion molecule expression in human coronary artery endothelial cells
A Stannard
Atherosclerosis 2001
Estrogen and Cerebrovascular Physiology and Pathophysiology
DA Pelligrino, E Galea
The Japanese Journal of Pharmacology 2001
VEGF-B expression in human primary breast cancers is associated with lymph node metastasis but not angiogenesis
SP Gunningham, MJ Currie, C Han, BA Robinson, PA Scott, AL Harris, SB Fox
The Journal of Pathology 2001
Estrogen effect on post-exercise skeletal muscle neutrophil infiltration and calpain activity
PM Tiidus, D Holden, E Bombardier, S Zajchowski, D Enns, A Belcastro
Canadian Journal of Physiology and Pharmacology 2001
Association of Circulating Cellular Adhesion Molecules with Menopausal Status and Hormone Replacement Therapy
E Oger, M Alhenc-Gelas, G Plu-Bureau, L Mennen, M Cambillau, L Guize, Y Pujol, PY Scarabin
Thrombosis Research 2001
The endothelium: a gynecological and obstetric point of view
MC Verhaar, TJ Rabelink
European Journal of Obstetrics & Gynecology and Reproductive Biology 2001
PPARα and GR Differentially Down-Regulate the Expression of Nuclear Factor-κB-Responsive Genes in Vascular Endothelial Cells
X Xu, M Otsuki, H Saito, S Sumitani, H Yamamoto, N Asanuma, H Kouhara, S Kasayama
Endocrinology 2001
Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms
RK Dubey, EK Jackson
American journal of physiology. Renal physiology 2001
Combined hormone replacement therapy improves endothelial function in healthy postmenopausal women
B Guzic-Salobir, I Keber, I Seljeflot, H Arnesen, L Vrabic
Journal of Internal Medicine 2001
Estrogen and Angiogenesis: A Review
DW Losordo, JM Isner
Arteriosclerosis, thrombosis, and vascular biology 2001
Progesterone, but Not Medroxyprogesterone, Inhibits Vascular Cell Adhesion Molecule-1 Expression in Human Vascular Endothelial Cells
M Otsuki, H Saito, X Xu, S Sumitani, H Kouhara, T Kishimoto, S Kasayama
Arteriosclerosis, thrombosis, and vascular biology 2001
Modern Immunosuppressives
HJ Schuurman, G Feutren, JF Bach
2001
Estrogen — Mystery Drug for the Brain?
C Behl
2001
Hormonal Carcinogenesis III
JJ Li, SA Li, JR Daling
2001
The Role of CBP in Estrogen Receptor Cross-Talk with Nuclear Factor-κB in HepG2 Cells
DC Harnish, MS Scicchitano, SJ Adelman, CR Lyttle, SK Karathanasis
Endocrinology 2000
Endothelial dysfunctions: common denominators in vascular disease
RD Caterina
Current Opinion in Lipidology 2000
Transdermal estrogens do not appear to modify the extent of lesional areas of aortic atherosclerosis in oophorectomized rabbits on a cholesterol-rich diet
JE Blümel, C Castelo-Branco, P González, C Moyano, M Iturriaga, L Videla, A Sanjuán, A Cano
Atherosclerosis 2000
Direct vascular effects of estrogens and selective estrogen receptor modulators
T Simoncini, AR Genazzani
Current Opinion in Obstetrics and Gynecology 2000
Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39
S Kakolyris, SB Fox, M Koukourakis, A Giatromanolaki, N Brown, RD Leek, M Taylor, IM Leigh, KC Gatter, AL Harris
British Journal of Cancer 2000
Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling
KS Russell, MP Haynes, D Sinha, E Clerisme, JR Bender
Proceedings of the National Academy of Sciences 2000
Hormone replacement therapy in the prevention and treatment of atherosclerosis
L Mosca
Current Atherosclerosis Reports 2000
Tibolone inhibits leukocyte adhesion molecule expression in human endothelial cells
T Simoncini, AR Genazzani
Molecular and Cellular Endocrinology 2000
Mechanisms of estrogen action in the cardiovascular system
ME Mendelsohn
The Journal of Steroid Biochemistry and Molecular Biology 2000
DIFFERENT ROLES FOR ANDROGENS AND ESTROGENS IN THE SUSCEPTIBILITY TO AUTOIMMUNE RHEUMATIC DISEASES
M Cutolo, RL Wilder
Rheumatic Disease Clinics of North America 2000
HORMONE REPLACEMENT THERAPY AND CORONARY HEART DISEASE
LH Kuller
Medical Clinics of North America 2000
Nongenomic, ER-Mediated Activation of Endothelial Nitric Oxide Synthase: : How Does It Work? What Does It Mean?
ME Mendelsohn
Circulation research 2000
Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein
MM Sadeghi, M Collinge, R Pardi, JR Bender
Journal of immunology (Baltimore, Md. : 1950) 2000
Clinically used estrogens differentially inhibit human aortic smooth muscle cell growth and mitogen-activated protein kinase activity
RK Dubey, EK Jackson, DG Gillespie, LC Zacharia, B Imthurn, PJ Keller
Arteriosclerosis, thrombosis, and vascular biology 2000
Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms
T Simoncini, S Maffei, G Basta, G Barsacchi, AR Genazzani, JK Liao, RD Caterina
Circulation research 2000
Expression of adhesion molecules LFA-I and ICAM-I on osteoclast precursors during osteoclast differentiation and involvement of estrogen deficiency
Y Gao, I Morita, T Kubota, S Murota, T Aso
Climacteric 2000
Low-Dose Contraceptive Estrogen-Progestin and Coronary Artery Atherosclerosis of Monkeys:
MR Adams, MS Anthony, JM Manning, DL Golden, JS Parks
Obstetrics & Gynecology 2000
Competition for p300 Regulates Transcription by Estrogen Receptors and Nuclear Factor-κB in Human Coronary Smooth Muscle Cells
E Speir, ZX Yu, K Takeda, VJ Ferrans, RO Cannon
Circulation research 2000
Oxidative Stress and Vascular Disease
JF Keaney
2000
Biology of Menopause
FL Bellino
2000
Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor
GB Stefano, P Cadet, C Breton, Y Goumon, V Prevot, JP Dessaint, JC Beauvillain, AS Roumier, I Welters, M Salzet
Blood 2000
Molecular mechanisms of estrogen actions on the vasculature
M Haynes, K Russell, J Bender
Journal of Nuclear Cardiology 2000
Estrogen and vascular resistance
M Barton, TF Lüscher
Current Opinion in Endocrinology & Diabetes 1999
GENDER DIFFERENCES AND ENDOTHELIUM- AND PLATELET-DERIVED FACTORS IN THE CORONARY CIRCULATION
VM Miller, DA Lewis, DA Barber
Clinical and Experimental Pharmacology and Physiology 1999
Sex differences in leukocyte invasion in injured murine skeletal muscle
BS Schneider, LA Correia, JG Cannon
Research in Nursing & Health 1999
Effect of Estradiol and Progesterone on the Low-Dose Endotoxin-Induced Glomerular Inflammatory Response of the Female Rat
MM Faas, WW Bakker, N Valkhof, GA Schuiling
American Journal of Reproductive Immunology 1999
A Pilot Study of Estrogen’s Effects on Bronchial Myocyte Adhesion Molecule Expression
GR Dickens, CJ Matheny, PE Morris, GD Clifton, MH Ensom
Pharmacotherapy 1999
Sex hormones and gender-related differences: Their influence on chronic renal allograft rejection
V Muller, A Szabo, O Viklicky, I Gaul, S Portl, T Philipp, UW Heemann
Kidney International 1999
Estrogen Reduces Leukocyte Adhesion in the Cerebral Circulation of Female Rats
R Santizo, DA Pelligrino
Journal of Cerebral Blood Flow & Metabolism 1999
Short-term hormone replacement therapy: reduced plasma levels of soluble adhesion molecules
van Baal, Emeis, Kenemans, Kessel, Peters-Muller, Schalkwijk, van der Mooren, Stehouwer
European Journal of Clinical Investigation 1999
Long-term effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity in healthy postmenopausal women
WM Baal, P Kenemans, JJ Emeis, CG Schalkwijk, V Mijatovic, MJ van der Mooren, UM Vischer, CD Stehouwer
Fertility and Sterility 1999
Estrogen and vascular resistance:
M Barton, TF Lüscher
Current Opinion in Endocrinology & Diabetes 1999
Gender and vascular reactivity
VM Miller
Lupus 1999
Estrogen improves acetylcholine-induced but not metabolic vasodilation in biological males
G New, SJ Duffy, RW Harper, IT Meredith
American journal of physiology. Heart and circulatory physiology 1999
Estradiol Inhibits Leukocyte Adhesion and Transendothelial Migration in Rabbits In Vivo: Possible Mechanisms for Gender Differences in Atherosclerosis
L Nathan, S Pervin, R Singh, M Rosenfeld, G Chaudhuri
Circulation research 1999
Estrogen and Progesterone Reduce Lipid Accumulation in Human Monocyte-Derived Macrophages: A Sex-Specific Effect
JA McCrohon, S Nakhla, W Jessup, KK Stanley, DS Celermajer
Circulation 1999
Vascular Effects of Estrogen and Vitamin E Therapies in Postmenopausal Women
KK Koh, A Blum, L Hathaway, R Mincemoyer, G Csako, MA Waclawiw, JA Panza, RO Cannon
Circulation 1999
Androgen Exposure Increases Human Monocyte Adhesion to Vascular Endothelium and Endothelial Cell Expression of Vascular Cell Adhesion Molecule-1
JA McCrohon, W Jessup, DJ Handelsman, DS Celermajer
Circulation 1999
Vascular Effects of Estrogen and Cholesterol-Lowering Therapies in Hypercholesterolemic Postmenopausal Women
KK Koh, C Cardillo, MN Bui, L Hathaway, G Csako, MA Waclawiw, JA Panza, RO Cannon
Circulation 1999
Estrogen Provides Neuroprotection in Transient Forebrain Ischemia Through Perfusion-Independent Mechanisms in Rats
Q Wang, R Santizo, VL Baughman, DA Pelligrino
Stroke; a journal of cerebral circulation 1999
Hormones and the Heart in Health and Disease
L Share
1999
Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen-activated protein kinase-independent pathway
RH Karas, EA Gauer, HE Bieber, WE Baur, ME Mendelsohn
Journal of Clinical Investigation 1998
Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease
T Caulin-Glaser, WJ Farrell, SE Pfau, B Zaret, K Bunger, JF Setaro, JJ Brennan, JR Bender, MW Cleman, HS Cabin, MS Remetz
Journal of the American College of Cardiology 1998
Estrogens and atherosclerosis: phytoestrogens and selective estrogen receptor modulators
RW st Clair
Current Opinion in Lipidology 1998
Apolipoprotein E and regulation of cytokine-induced cell adhesion molecule expression in endothelial cells
AK Stannard, DR Riddell, NJ Bradley, DG Hassall, A Graham, JS Owen
Atherosclerosis 1998
Effects of oestrogens and selective oestrogen receptor modulators on serum lipoproteins and vascular function
A Blum, RO Cannon
Current Opinion in Lipidology 1998
The Biology of Estrogen-Mediated Repair of Cardiovascular Injury
CH MD, TA MD, BD MD, EJ MD, BC MD, AH MD
The Annals of Thoracic Surgery 1998
Tumor Growth of FGF or VEGF Transfected MCF-7 Breast Carcinoma Cells Correlates with Density of Specific Microvessels Independent of the Transfected Angiogenic Factor
SW McLeskey, CA Tobias, PR Vezza, AC Filie, FG Kern, J Hanfelt
The American Journal of Pathology 1998
T lymphocytes are not the target for estradiol-mediated suppression of DTH in reconstituted female severe combined immunodeficient (SCID) mice
M Taube, L Svensson, H Carlsten
Clinical & Experimental Immunology 1998
The oestrogen receptor regulates NFκB and AP-1 activity in a cell-specific manner
G Cerillo, A Rees, N Manchanda, C Reilly, I Brogan, A White, M Needham
The Journal of Steroid Biochemistry and Molecular Biology 1998
Vascular Surgery
JM FACS
Journal of the American College of Surgeons 1998
Effect of Iodinated Contrast Media on Neutrophil Adhesion to Cultured Endothelial Cells
PE Thorpe, X Zhan, DK Agrawal
Journal of Vascular and Interventional Radiology 1998
Leukocyte-endothelium adhesion molecules in atherosclerosis
ZM Dong, DD Wagner
Journal of Laboratory and Clinical Medicine 1998
Biologic markers as predictors of cardiovascular disease
WH Frishman
The American Journal of Medicine 1998
Human Umbilical Vein Endothelial Cells Lack Expression of the Estrogen Receptor
I Jensen, CH Rinaldo, LN Berge, OM Seternes, U Moens
Endothelium : journal of endothelial cell research 1998
Estrogen replacement therapy and cardiovascular protection: Lipid mechanisms are the tip of an iceberg
A Nasr, M Breckwoldt
Gynecological Endocrinology 1998
Estrogen increases the permeability of the cultured human cervical epithelium by modulating cell deformability
GI Gorodeski
American journal of physiology. Cell physiology 1998
ESTRADIOL INHIBITS ALLOGRAFT-INDUCIBLE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II ANTIGEN EXPRESSION AND TRANSPLANT ARTERIOSCLEROSIS IN THE ABSENCE OF IMMUNOSUPPRESSION1:
S Saito, ML Foegh, N Motomura, H Lou, K Kent, PW Ramwell
Transplantation 1998
Increased Expression of Estrogen Receptor-β mRNA in Male Blood Vessels After Vascular Injury
V Lindner, SK Kim, RH Karas, GG Kuiper, JA Gustafsson, ME Mendelsohn
Circulation research 1998
Soluble Cell Adhesion Molecules in Hypertriglyceridemia and Potential Significance on Monocyte Adhesion
Y Abe, B El-Masri, KT Kimball, H Pownall, CF Reilly, K Osmundsen, CW Smith, CM Ballantyne
Arteriosclerosis, thrombosis, and vascular biology 1998
17β-Estradiol, Its Metabolites, and Progesterone Inhibit Cardiac Fibroblast Growth
RK Dubey, DG Gillespie, EK Jackson, PJ Keller
Hypertension 1998
Endocrinology of Cardiovascular Function
ER Levin, JL Nadler
1998
Absence of P-selectin delays fatty streak formation in mice
RC Johnson, SM Chapman, ZM Dong, JM Ordovas, TN Mayadas, J Herz, RO Hynes, EJ Schaefer, DD Wagner
Journal of Clinical Investigation 1997
Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice
MD Iafrati, RH Karas, M Aronovitz, S Kim, TR Sullivan, DB Lubahn, TF O'Donnell, KS Korach, ME Mendelsohn
Nature Medicine 1997
ESTROGENS AND ATHEROSCLEROSIS
LN and, G Chaudhuri
Annual Review of Pharmacology and Toxicology 1997
Chronic Estrogen Replacement Inhibits Aortic Intimal Hyperplasia Independent of Serum Lipids
CH Selzman, AS Turner, SM Johnson, BS Cain, AH Harken, TA Whitehill
Journal of Cardiac Surgery 1997
Effects of Hormone Therapy on Inflammatory Cell Adhesion Molecules in Postmenopausal Healthy Women
KK MD, MN MD, RM RN, RO MD
The American Journal of Cardiology 1997
17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization
T Caulin-Glaser, G García-Cardeña, P Sarrel, WC Sessa, JR Bender
Circulation research 1997
Human Umbilical Vessels and Cultured Umbilical Vein Endothelial and Smooth Muscle Cells Lack Detectable Protein and mRNA Endocing Estrogen Receptors
VL Baker, VA Chao, JT Murai, CJ Zaloudek, RN Taylor
Journal of the Society for Gynecologic Investigation 1997
The 27-kDa Heat Shock Protein Facilitates Basic Fibroblast Growth Factor Release from Endothelial Cells
RS Piotrowicz, JL Martin, WH Dillman, EG Levin
The Journal of biological chemistry 1997
Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones
JR Lancaster, JF Parkinson
1997
Biphasic estrogen response on bovine adrenal medulla capillary endothelial cell adhesion, proliferation and tube formation
S K Banerjee, D R Campbell, A P Weston, D K Banerjee
Molecular and Cellular Biochemistry 1997
Multiple Risk Factors in Cardiovascular Disease
AM Gotto, C Lenfant, AL Catapano, R Paoletti
1995

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