One of the earliest events in atherosclerosis is interaction of circulating mononuclear leukocytes and the endothelium. Endothelial cell (EC) activation by cytokines results in expression of adhesion molecules and production of chemotactic factors, augmenting leukocyte adhesion and recruitment, respectively. The incidence of atherosclerosis in premenopausal women is significantly less than that observed in age-matched males with similar risk profiles. Because estrogen has gene regulatory effects, we investigated whether 17beta-estradiol (E2) can inhibit cytokine-mediated EC adhesion molecule transcriptional activation. Cultured human umbilical vein EC (estrogen receptor-positive) were propagated in gonadal hormone-free medium and were E2-pretreated for 48 h before IL-1 activation. Detected by FACS analysis, E2 strongly (60-80%) inhibited IL-1-mediated membrane E-selectin and vascular cell adhesion molecule-1 induction, and intercellular adhesion molecule-1 hyperinduction. 17alpha-estradiol (an inactive E2 stereoisomer) had no effect. This inhibition correlated with similar reductions in steady state-induced E-selectin mRNA levels, and was abrogated by the E2 antagonist ICI 164,384, demonstrating a specific, estrogen receptor-mediated effect. Nuclear run-offs confirmed suppression at the transcriptional level. The implications of these results for the cardiovascular protective role of estrogen are discussed.
T Caulin-Glaser, C A Watson, R Pardi, J R Bender
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Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Smit V, de Mol J, Kleijn MN, Depuydt MA, de Winther MP, Bot I, Kuiper J, Foks AC |
Immunity & ageing : I & A | 2024 |
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Zhu BT, Liao QQ, Tian HY, Yu DJ, Xie T, Sun XL, Zhou XM, Han YX, Zhao YJ, El-Kassas M, Liu XX, Sun XD, Zhang YY |
Frontiers in pharmacology | 2024 |
Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner
Hopkin SJ, Pezhman L, Begum J, Kavanagh D, McGettrick HM, Iqbal AJ, Chimen M |
Journal of leukocyte biology | 2023 |
Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society
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European Heart Journal | 2023 |
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Dietrich E, Jomard A, Osto E |
Frontiers in Cardiovascular Medicine | 2022 |
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Circulation research | 2020 |
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Experimental biology and medicine (Maywood, N.J.) | 2017 |
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Hormone Research in Pædiatrics | 2017 |
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Circulation research | 2016 |
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International journal of environmental research and public health | 2014 |
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Revista chilena de obstetricia y ginecología | 2014 |
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The Journal of clinical endocrinology and metabolism | 2014 |
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Journal of Endocrinology | 2013 |
Estrogen Alleviates Acetic Acid-Induced Gastric or Colonic Damage via Both ERα- and ERβ-Mediated and Direct Antioxidant Mechanisms in Rats
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Inflammation | 2013 |
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Biochemical and Biophysical Research Communications | 2013 |
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Atherosclerosis | 2012 |
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Endocrine Connections | 2012 |
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American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2011 |
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Life Sciences | 2010 |
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The Journal of Steroid Biochemistry and Molecular Biology | 2010 |
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Proceedings of the National Academy of Sciences | 2009 |
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Frontiers in bioscience : a journal and virtual library | 2009 |
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Molecular and Cellular Endocrinology | 2009 |
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Acta Odontologica Scandinavica | 2009 |
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Anesthesia & Analgesia | 2009 |
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Hormonal Replacement Therapy After Menopause Is Protective of Disease Activity in Women With Inflammatory Bowel Disease
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The American Journal of Gastroenterology | 2008 |
Inflammation, coronary artery disease, and hormones
RA Lobo |
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Efecto de diosgenina sobre la proteína C reactiva y homocisteína en pacientes menopáusicas
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Clínica e Investigación en Ginecología y Obstetricia | 2008 |
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Maturitas | 2008 |
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Archives of Oral Biology | 2008 |
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Fertility and Sterility | 2008 |
The Effect of Isolation Methods and the Use of Different Enzymes on Islet Yield and In Vivo Function
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Cell Transplantation | 2008 |
Vascular Actions of Estrogens: Functional Implications
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Pharmacological reviews | 2008 |
Heat Shock Protein 72 Response to Exercise in Humans:
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Sports Medicine | 2008 |
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Gynecological Endocrinology | 2007 |
The Complex Role of Estrogens in Inflammation
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Endocrine reviews | 2007 |
Estrogen increases apoptosis in the arterial wall in a murine atherosclerosis model
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Fertility and Sterility | 2007 |
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Endocrinology | 2007 |
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Shock | 2007 |
Consumption of isoflavone-rich soy protein does not alter homocysteine or markers of inflammation in postmenopausal women
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European Journal of Clinical Nutrition | 2007 |
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American journal of physiology. Heart and circulatory physiology | 2007 |
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The FASEB Journal | 2007 |
Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies
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Journal of Cellular Physiology | 2006 |
Suppression of Extravillous Trophoblast Invasion of Uterine Spiral Arteries by Estrogen During Early Baboon Pregnancy
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Inflammation and Atherosclerosis
EA Kaperonis, CD Liapis, JD Kakisis, D Dimitroulis, VG Papavassiliou |
European Journal of Vascular and Endovascular Surgery | 2006 |
The Pathway-selective Estrogen Receptor Ligand WAY-169916 Displays Differential Activity in Ischemia-Reperfusion Injury Models
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Journal of Cardiovascular Pharmacology | 2006 |
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Steroids | 2006 |
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American Journal of Reproductive Immunology | 2006 |
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Expert Opinion on Therapeutic Patents | 2006 |
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Medical Hypotheses | 2006 |
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Journal of leukocyte biology | 2006 |
Blood-Brain Barriers: From Ontogeny to Artificial Interfaces
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2006 | |
Estrogens as Neuroprotectants against Ischemic Stroke
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Endocrine Journal | 2006 |
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Proceedings of the National Academy of Sciences | 2005 |
Estrogen, progesterone, and cardiovascular health: when shall we complete the puzzle?
A Brzezinski, HD Danenberg |
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Improvement of Function and Morphology of Tumor Necrosis Factor-α Treated Endothelial Cells With 17-β Estradiol
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Circulation Journal | 2005 |
Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus
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Atherosclerosis | 2005 |
Novel action of estrone on vascular tissue: regulation of NOS and COX activity
J Selles, N Polini, C Alvarez, V Massheimer |
Steroids | 2005 |
Endothelium-dependent dilatory effects of 3??-OH-tibolone in gracilis muscle arterioles of the female Wistar rat
IJ Korstjens, RG Smolders, MJ van der Mooren, HJ Kloosterboer, P Kenemans, P Sipkema |
Menopause | 2005 |
Regulation of nuclear factor-κB (NF-κB) activity and apoptosis by estradiol in bovine granulosa cells
KE Valdez, AM Turzillo |
Molecular and Cellular Endocrinology | 2005 |
OP-142 Gene Expression Profile of Nonfunctional Human Pancreatic Islets: Predictors of Transplant Failure?
OM Sabek, DR Marshall, O Minoru, DW Fraga, AO Gaber |
Transplantation Proceedings | 2005 |
Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERα and ERβ levels: Sex steroid and pregnancy regulation of ERα and ERβ
MJ Byers, A Zangl, TM Phernetton, G Lopez, D Chen, RR Magness |
The Journal of Physiology | 2005 |
Regulatory effects of estrogen on acute lung inflammation in mice
CL Speyer, NJ Rancilio, SD McClintock, JD Crawford, H Gao, JV Sarma, PA Ward |
American journal of physiology. Cell physiology | 2005 |
The Acute Estrogenic Dilation of Rat Aorta Is Mediated Solely by Selective Estrogen Receptor-α Agonists and Is Abolished by Estrogen Deprivation
C Bolego, A Cignarella, P Sanvito, V Pelosi, F Pellegatta, L Puglisi, C Pinna |
The Journal of pharmacology and experimental therapeutics | 2005 |
Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis
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Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Do estrogen effects on blood vessels translate into clinically significant atheroprotection?
S Pradhan, BE Sumpio |
Journal of the American College of Surgeons | 2004 |
T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis
MJ Polanczyk, RE Jones, S Subramanian, M Afentoulis, C Rich, M Zakroczymski, P Cooke, AA Vandenbark, H Offner |
The American Journal of Pathology | 2004 |
Biological determinants of serum ICAM-1, E-selectin, P-selectin and L-selectin levels in healthy subjects: the Stanislas study
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Atherosclerosis | 2004 |
Estrogen induced changes in Akt-dependent activation of endothelial nitric oxide synthase and vasodilation
M Florian, Y Lu, M Angle, S Magder |
Steroids | 2004 |
Treatment with 17-β-estradiol reduces superoxide production in aorta of ovariectomized rats
M Florian, A Freiman, S Magder |
Steroids | 2004 |
Advances in long-term islet culture
AO Gaber, D Fraga |
Cell Biochemistry and Biophysics | 2004 |
Tissue-specific effect of estradiol on endothelial cell-dependent lymphocyte recruitment
HS Murphy, Q Sun, BA Murphy, RR Mo, J Huo, J Chen, SW Chensue, M Adams, BC Richardson, R Yung |
Microvascular Research | 2004 |
RORα1 and RORα4 suppress TNF-α-induced VCAM-1 and ICAM-1 expression in human endothelial cells
H Migita, N Satozawa, JH Lin, J Morser, K Kawai |
FEBS Letters | 2004 |
Ischemic heart disease in women and the role of hormone therapy
JA Raza, RA Reinhart, A Movahed |
International Journal of Cardiology | 2004 |
Advances in long-term islet culture: The memphis experience
AO Gaber, D Fraga |
Cell Biochemistry and Biophysics | 2004 |
The Levels of Soluble Adhesion Molecules in Diabetic and Nondiabetic Patients with Combined Hyperlipoproteinemia and the Effect of Ciprofibrate Therapy
J Okapcova, D Gabor |
Angiology | 2004 |
Hormone Replacement Therapy and Peripheral Vascular Disease in Women
L Nguyen, DR Liles, PH Lin, RL Bush |
Vascular and endovascular surgery | 2004 |
Altered gene expression in human cells induced by the agricultural chemical Enable
T Mankame, R Hokanson, R Chowdhary, D Busbee |
Toxicology and industrial health | 2004 |
Estrogen suppresses IL-1β-mediated induction of COX-2 pathway in rat cerebral blood vessels
JA Ospina, HN Brevig, DN Krause, SP Duckles |
American journal of physiology. Heart and circulatory physiology | 2004 |
The atheroprotective effect of 17β-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice
P Gourdy, Z Mallat, C Castano, B Garmy-Susini, JL Gregor, A Tedgui, JF Arnal, F Bayard |
Atherosclerosis | 2003 |
Dehydroepiandrosterone, an adrenalandrogen, increases human foam cell formation
MK Ng, S Nakhla, A Baoutina, W Jessup, DJ Handelsman, DS Celermajer |
Journal of the American College of Cardiology | 2003 |
Soy isoflavones prevent ovariectomy-induced atherosclerotic lesions in Golden Syrian hamster model of postmenopausal hyperlipidemia
EA Lucas, SA Lightfoot, LJ Hammond, L Devareddy, DA Khalil, BP Daggy, DY Soung, BH Arjmandi |
Menopause | 2003 |
Steroid Receptors in the Uterus: Implications in Endometriosis
P Moutsatsou, CE Sekeris |
Annals of the New York Academy of Sciences | 2003 |
ER-α variants and the cardiovascular effects of hormone replacement therapy
DM Herrington, TD Howard |
Pharmacogenomics | 2003 |
ISOLATION OF MURINE AORTIC ENDOTHELIAL CELLS IN CULTURE AND THE EFFECTS OF SEX STEROIDS ON THEIR GROWTH
DW Lincoln, AM Larsen, PG Phillips, K Bove |
In Vitro Cellular & Developmental Biology - Animal | 2003 |
The role of estrogen in cardiovascular disease
L Baker, KK Meldrum, M Wang, R Sankula, R Vanam, A Raiesdana, B Tsai, K Hile, JW Brown, DR Meldrum |
Journal of Surgical Research | 2003 |
17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells
Daigo Sumi, Toshio Hayashi, Hisako Matsui-Hirai, Aaron T Jacobs, Louis J Ignarro, Akihisa Iguchi |
Biochimica et Biophysica Acta | 2003 |
Effects of estrogen on the vascular system
RC Tostes, D Nigro, ZB Fortes, MH Carvalho |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2003 |
Association between Gly241Arg ICAM-1 gene polymorphism and serum sICAM-1 concentration in the Stanislas cohort
A Ponthieux, D Lambert, B Herbeth, S Droesch, M Pfister, S Visvikis |
European Journal of Human Genetics | 2003 |
Effect of estradiol administration on splanchnic perfusion after trauma???hemorrhage and sepsis:
Y Yokoyama, MG Schwacha, KI Bland, IH Chaudry |
Current Opinion in Critical Care | 2003 |
Effects of tibolone on cell adhesion molecules in postmenopausal women:
C Egarter, M Sator, J Huber |
Menopause (New York, N.Y.) | 2003 |
Age- and Sex-related Reference Values for Serum Adhesion Molecule Concentrations in Healthy Individuals: Intercellular Adhesion Molecule-1 and E-, P-, and L-Selectin
A Ponthieux, B Herbeth, S Droesch, D Lambert, S Visvikis |
Clinical chemistry | 2003 |
Isolation of murine aortic endothelial cells in culture and the effects of sex steroids on their growth
DW Lincoln, AM Larsen, PG Phillips, K Bove |
In vitro cellular & developmental biology. Animal | 2003 |
Effects of continuous combined hormone replacement therapy on inflammation in hypertensive and/or overweight postmenopausal women
KK Koh, JY Ahn, DK Jin, BK Yoon, HS Kim, DS Kim, MS Shin, JW Son, IS Choi, EK Shin |
Arteriosclerosis, thrombosis, and vascular biology | 2002 |
The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptor-alpha
MR Adams, DL Golden, TC Register, MS Anthony, JB Hodgin, N Maeda, JK Williams |
Arteriosclerosis, thrombosis, and vascular biology | 2002 |
Minireview: Estrogen and Mouse Models of Atherosclerosis
JB Hodgin, N Maeda |
Endocrinology | 2002 |
Effects of transdermal hormone replacement therapy on levels of soluble P- and E-selectin in postmenopausal healthy women
A Farzati, K Esposito, N Colacurci, F Fornaro, V Chiantera, B Farzati |
Fertility and Sterility | 2002 |
Estrogen inhibits the initiation of fatty streaks throughout the vasculature but does not inhibit intra-plaque hemorrhage and the progression of established lesions in apolipoprotein E deficient mice
ME Rosenfeld, K Kauser, B Martin-McNulty, P Polinsky, SM Schwartz, GM Rubanyi |
Atherosclerosis | 2002 |
Estrogens and the Vascular Endothelium
MC Cid, HW Schnaper, HK Kleinman |
Annals of the New York Academy of Sciences | 2002 |
Androgens and Estrogens Modulate the Immune and Inflammatory Responses in Rheumatoid Arthritis
M Cutolo, B Seriolo, B Villaggio, C Pizzorni, C Craviotto, A Sulli |
Annals of the New York Academy of Sciences | 2002 |
Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis
TK Mukherjee, H Dinh, G Chaudhuri, L Nathan |
Proceedings of the National Academy of Sciences | 2002 |
The adhesion molecule ICAM-1 and its regulation in relation with the blood–brain barrier
JB Dietrich |
Journal of Neuroimmunology | 2002 |
17β-Estradiol inhibits cytokine induction of the human E-selectin promoter
CM Tyree, A Zou, EA Allegretto |
The Journal of Steroid Biochemistry and Molecular Biology | 2002 |
Effects of testosterone and 17-β-estradiol on TNF-α-induced E-selectin and VCAM-1 expression in endothelial cells
X Zhang, LY Wang, TY Jiang, HP Zhang, Y Dou, JH Zhao, H Zhao, ZD Qiao, JT Qiao |
Life Sciences | 2002 |
17β-estradiol inhibits the adhesion of leukocytes in TNF-α stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion, but not its transcription
E Rodrı́guez, R López, A Paez, F Massó, LF Montaño |
Life Sciences | 2002 |
Effects of Estrogen, Progesterone, and Combination Exposure on Interleukin-1β-Induced Expression of VCAM-1, ICAM-1, PECAM, and E-Selectin by Human Female Iliac Artery Endothelial Cells
KT Piercy, RL Donnell, SS Kirkpatrick, CH Timaran, SL Stevens, MB Freeman, MH Goldman |
Journal of Surgical Research | 2002 |
Estradiol reduces basal and cytokine induced monocyte adhesion to endothelial cells
TS Mikkola, RW St.Clair |
Maturitas | 2002 |
Lack of stimulatory effect of dienogest on the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by endothelial cell as compared with other synthetic progestins
H Tatsumi |
Maturitas | 2002 |
Rapid vascular cell responses to estrogen and membrane receptors
MP Haynes, L Li, KS Russell, JR Bender |
Vascular Pharmacology | 2002 |
Estrogen and vascular function
RE White |
Vascular Pharmacology | 2002 |
Update on cardiovascular disease in post-menopausal women
GI Gorodeski |
Best Practice & Research Clinical Obstetrics & Gynaecology | 2002 |
Reproductive hormones and cardiovascular disease
JD Wagner, JR Kaplan, RT Burkman |
Obstetrics and Gynecology Clinics of North America | 2002 |
Estrogen and apoptosis in atherosclerosis
M Barton, MM Kockx |
International Congress Series | 2002 |
Sex steroids and the immune system
E Seli, A Arici |
Immunology and Allergy Clinics of North America | 2002 |
Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells
S Ling, A Dai, MR Williams, K Myles, RJ Dilley, PA Komesaroff, K Sudhir |
Endocrinology | 2002 |
The inhibitory effect of soy protein isolate on atherosclerosis in mice does not require the presence of LDL receptors or alteration of plasma lipoproteins
MR Adams, DL Golden, MS Anthony, TC Register, JK Williams |
The Journal of nutrition | 2002 |
Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
A Louissaint, S Rao, C Leventhal, SA Goldman |
Neuron | 2002 |
Estrogen replacement therapy and cardioprotection: mechanisms and controversies
MT Subbiah |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2002 |
Acute effects of 17β-estradiol on femoral veins from adult gonadally intact and ovariectomized female pigs
MP Bracamonte, M Jayachandran, KS Rud, VM Miller |
American journal of physiology. Heart and circulatory physiology | 2002 |
Modulatory effects of estrogen in two murine models of experimental colitis
EF Verdú, Y Deng, P Bercik, SM Collins |
AJP Gastrointestinal and Liver Physiology | 2002 |
Time- and dose-dependent differential upregulation of three genes by 17β-estradiol in endothelial cells
AC Villablanca, KA Lewis, JC Rutledge |
Journal of applied physiology | 2002 |
Estrogen inhibits NF??B-dependent inflammationin brain endothelium without interfering withI??B degradation:
E Galea, R Santizo, DL Feinstein, P Adamsom, J Greenwood, HM Koenig, DA Pelligrino |
NeuroReport | 2002 |
Estrogen Receptor-α Mediates the Protective Effects of Estrogen Against Vascular Injury
G Pare, A Krust, RH Karas, S Dupont, M Aronovitz, P Chambon, ME Mendelsohn |
Circulation research | 2002 |
Estrogen Causes Dynamic Alterations in Endothelial Estrogen Receptor Expression
CE Ihionkhan, KL Chambliss, LL Gibson, LD Hahner, ME Mendelsohn, PW Shaul |
Circulation research | 2002 |
Estrogens Inhibit Angiotensin II–Induced Leukocyte–Endothelial Cell Interactions In Vivo via Rapid Endothelial Nitric Oxide Synthase and Cyclooxygenase Activation
A Álvarez, C Hermenegildo, AC Issekutz, JV Esplugues, MJ Sanz |
Circulation research | 2002 |
Exercise-Induced Muscle Damage and the Potential Protective Role of Estrogen:
B Kendall, R Eston |
Sports Medicine | 2002 |
Estrogen receptor alpha is a major mediator of the atheroprotective effect of 17beta-estradiol in Apoe-/- mice
Jeffrey B. Hodgin, John H. Krege, Robert L. Reddick, Kenneth S. Korach, Oliver Smithies, Nobuyo Maeda |
Journal of Clinical Investigation | 2001 |
Inability of plasma high-density lipoproteins to inhibit cell adhesion molecule expression in human coronary artery endothelial cells
A Stannard |
Atherosclerosis | 2001 |
Estrogen and Cerebrovascular Physiology and Pathophysiology
DA Pelligrino, E Galea |
The Japanese Journal of Pharmacology | 2001 |
VEGF-B expression in human primary breast cancers is associated with lymph node metastasis but not angiogenesis
SP Gunningham, MJ Currie, C Han, BA Robinson, PA Scott, AL Harris, SB Fox |
The Journal of Pathology | 2001 |
Estrogen effect on post-exercise skeletal muscle neutrophil infiltration and calpain activity
PM Tiidus, D Holden, E Bombardier, S Zajchowski, D Enns, A Belcastro |
Canadian Journal of Physiology and Pharmacology | 2001 |
Association of Circulating Cellular Adhesion Molecules with Menopausal Status and Hormone Replacement Therapy
E Oger, M Alhenc-Gelas, G Plu-Bureau, L Mennen, M Cambillau, L Guize, Y Pujol, PY Scarabin |
Thrombosis Research | 2001 |
The endothelium: a gynecological and obstetric point of view
MC Verhaar, TJ Rabelink |
European Journal of Obstetrics & Gynecology and Reproductive Biology | 2001 |
PPARα and GR Differentially Down-Regulate the Expression of Nuclear Factor-κB-Responsive Genes in Vascular Endothelial Cells
X Xu, M Otsuki, H Saito, S Sumitani, H Yamamoto, N Asanuma, H Kouhara, S Kasayama |
Endocrinology | 2001 |
Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms
RK Dubey, EK Jackson |
American journal of physiology. Renal physiology | 2001 |
Combined hormone replacement therapy improves endothelial function in healthy postmenopausal women
B Guzic-Salobir, I Keber, I Seljeflot, H Arnesen, L Vrabic |
Journal of Internal Medicine | 2001 |
Estrogen and Angiogenesis: A Review
DW Losordo, JM Isner |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Progesterone, but Not Medroxyprogesterone, Inhibits Vascular Cell Adhesion Molecule-1 Expression in Human Vascular Endothelial Cells
M Otsuki, H Saito, X Xu, S Sumitani, H Kouhara, T Kishimoto, S Kasayama |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Modern Immunosuppressives
HJ Schuurman, G Feutren, JF Bach |
2001 | |
Estrogen — Mystery Drug for the Brain?
C Behl |
2001 | |
Hormonal Carcinogenesis III
JJ Li, SA Li, JR Daling |
2001 | |
The Role of CBP in Estrogen Receptor Cross-Talk with Nuclear Factor-κB in HepG2 Cells
DC Harnish, MS Scicchitano, SJ Adelman, CR Lyttle, SK Karathanasis |
Endocrinology | 2000 |
Endothelial dysfunctions: common denominators in vascular disease
RD Caterina |
Current Opinion in Lipidology | 2000 |
Transdermal estrogens do not appear to modify the extent of lesional areas of aortic atherosclerosis in oophorectomized rabbits on a cholesterol-rich diet
JE Blümel, C Castelo-Branco, P González, C Moyano, M Iturriaga, L Videla, A Sanjuán, A Cano |
Atherosclerosis | 2000 |
Direct vascular effects of estrogens and selective estrogen receptor modulators
T Simoncini, AR Genazzani |
Current Opinion in Obstetrics and Gynecology | 2000 |
Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39
S Kakolyris, SB Fox, M Koukourakis, A Giatromanolaki, N Brown, RD Leek, M Taylor, IM Leigh, KC Gatter, AL Harris |
British Journal of Cancer | 2000 |
Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling
KS Russell, MP Haynes, D Sinha, E Clerisme, JR Bender |
Proceedings of the National Academy of Sciences | 2000 |
Hormone replacement therapy in the prevention and treatment of atherosclerosis
L Mosca |
Current Atherosclerosis Reports | 2000 |
Tibolone inhibits leukocyte adhesion molecule expression in human endothelial cells
T Simoncini, AR Genazzani |
Molecular and Cellular Endocrinology | 2000 |
Mechanisms of estrogen action in the cardiovascular system
ME Mendelsohn |
The Journal of Steroid Biochemistry and Molecular Biology | 2000 |
DIFFERENT ROLES FOR ANDROGENS AND ESTROGENS IN THE SUSCEPTIBILITY TO AUTOIMMUNE RHEUMATIC DISEASES
M Cutolo, RL Wilder |
Rheumatic Disease Clinics of North America | 2000 |
HORMONE REPLACEMENT THERAPY AND CORONARY HEART DISEASE
LH Kuller |
Medical Clinics of North America | 2000 |
Nongenomic, ER-Mediated Activation of Endothelial Nitric Oxide Synthase: : How Does It Work? What Does It Mean?
ME Mendelsohn |
Circulation research | 2000 |
Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein
MM Sadeghi, M Collinge, R Pardi, JR Bender |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Clinically used estrogens differentially inhibit human aortic smooth muscle cell growth and mitogen-activated protein kinase activity
RK Dubey, EK Jackson, DG Gillespie, LC Zacharia, B Imthurn, PJ Keller |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms
T Simoncini, S Maffei, G Basta, G Barsacchi, AR Genazzani, JK Liao, RD Caterina |
Circulation research | 2000 |
Expression of adhesion molecules LFA-I and ICAM-I on osteoclast precursors during osteoclast differentiation and involvement of estrogen deficiency
Y Gao, I Morita, T Kubota, S Murota, T Aso |
Climacteric | 2000 |
Low-Dose Contraceptive Estrogen-Progestin and Coronary Artery Atherosclerosis of Monkeys:
MR Adams, MS Anthony, JM Manning, DL Golden, JS Parks |
Obstetrics & Gynecology | 2000 |
Competition for p300 Regulates Transcription by Estrogen Receptors and Nuclear Factor-κB in Human Coronary Smooth Muscle Cells
E Speir, ZX Yu, K Takeda, VJ Ferrans, RO Cannon |
Circulation research | 2000 |
Oxidative Stress and Vascular Disease
JF Keaney |
2000 | |
Biology of Menopause
FL Bellino |
2000 | |
Estradiol-stimulated nitric oxide release in human granulocytes is dependent on intracellular calcium transients: evidence of a cell surface estrogen receptor
GB Stefano, P Cadet, C Breton, Y Goumon, V Prevot, JP Dessaint, JC Beauvillain, AS Roumier, I Welters, M Salzet |
Blood | 2000 |
Molecular mechanisms of estrogen actions on the vasculature
M Haynes, K Russell, J Bender |
Journal of Nuclear Cardiology | 2000 |
Estrogen and vascular resistance
M Barton, TF Lüscher |
Current Opinion in Endocrinology & Diabetes | 1999 |
GENDER DIFFERENCES AND ENDOTHELIUM- AND PLATELET-DERIVED FACTORS IN THE CORONARY CIRCULATION
VM Miller, DA Lewis, DA Barber |
Clinical and Experimental Pharmacology and Physiology | 1999 |
Sex differences in leukocyte invasion in injured murine skeletal muscle
BS Schneider, LA Correia, JG Cannon |
Research in Nursing & Health | 1999 |
Effect of Estradiol and Progesterone on the Low-Dose Endotoxin-Induced Glomerular Inflammatory Response of the Female Rat
MM Faas, WW Bakker, N Valkhof, GA Schuiling |
American Journal of Reproductive Immunology | 1999 |
A Pilot Study of Estrogen’s Effects on Bronchial Myocyte Adhesion Molecule Expression
GR Dickens, CJ Matheny, PE Morris, GD Clifton, MH Ensom |
Pharmacotherapy | 1999 |
Sex hormones and gender-related differences: Their influence on chronic renal allograft rejection
V Muller, A Szabo, O Viklicky, I Gaul, S Portl, T Philipp, UW Heemann |
Kidney International | 1999 |
Estrogen Reduces Leukocyte Adhesion in the Cerebral Circulation of Female Rats
R Santizo, DA Pelligrino |
Journal of Cerebral Blood Flow & Metabolism | 1999 |
Short-term hormone replacement therapy: reduced plasma levels of soluble adhesion molecules
van Baal, Emeis, Kenemans, Kessel, Peters-Muller, Schalkwijk, van der Mooren, Stehouwer |
European Journal of Clinical Investigation | 1999 |
Long-term effects of combined hormone replacement therapy on markers of endothelial function and inflammatory activity in healthy postmenopausal women
WM Baal, P Kenemans, JJ Emeis, CG Schalkwijk, V Mijatovic, MJ van der Mooren, UM Vischer, CD Stehouwer |
Fertility and Sterility | 1999 |
Estrogen and vascular resistance:
M Barton, TF Lüscher |
Current Opinion in Endocrinology & Diabetes | 1999 |
Gender and vascular reactivity
VM Miller |
Lupus | 1999 |
Estrogen improves acetylcholine-induced but not metabolic vasodilation in biological males
G New, SJ Duffy, RW Harper, IT Meredith |
American journal of physiology. Heart and circulatory physiology | 1999 |
Estradiol Inhibits Leukocyte Adhesion and Transendothelial Migration in Rabbits In Vivo: Possible Mechanisms for Gender Differences in Atherosclerosis
L Nathan, S Pervin, R Singh, M Rosenfeld, G Chaudhuri |
Circulation research | 1999 |
Estrogen and Progesterone Reduce Lipid Accumulation in Human Monocyte-Derived Macrophages: A Sex-Specific Effect
JA McCrohon, S Nakhla, W Jessup, KK Stanley, DS Celermajer |
Circulation | 1999 |
Vascular Effects of Estrogen and Vitamin E Therapies in Postmenopausal Women
KK Koh, A Blum, L Hathaway, R Mincemoyer, G Csako, MA Waclawiw, JA Panza, RO Cannon |
Circulation | 1999 |
Androgen Exposure Increases Human Monocyte Adhesion to Vascular Endothelium and Endothelial Cell Expression of Vascular Cell Adhesion Molecule-1
JA McCrohon, W Jessup, DJ Handelsman, DS Celermajer |
Circulation | 1999 |
Vascular Effects of Estrogen and Cholesterol-Lowering Therapies in Hypercholesterolemic Postmenopausal Women
KK Koh, C Cardillo, MN Bui, L Hathaway, G Csako, MA Waclawiw, JA Panza, RO Cannon |
Circulation | 1999 |
Estrogen Provides Neuroprotection in Transient Forebrain Ischemia Through Perfusion-Independent Mechanisms in Rats
Q Wang, R Santizo, VL Baughman, DA Pelligrino |
Stroke; a journal of cerebral circulation | 1999 |
Hormones and the Heart in Health and Disease
L Share |
1999 | |
Growth factor activation of the estrogen receptor in vascular cells occurs via a mitogen-activated protein kinase-independent pathway
RH Karas, EA Gauer, HE Bieber, WE Baur, ME Mendelsohn |
Journal of Clinical Investigation | 1998 |
Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease
T Caulin-Glaser, WJ Farrell, SE Pfau, B Zaret, K Bunger, JF Setaro, JJ Brennan, JR Bender, MW Cleman, HS Cabin, MS Remetz |
Journal of the American College of Cardiology | 1998 |
Estrogens and atherosclerosis: phytoestrogens and selective estrogen receptor modulators
RW st Clair |
Current Opinion in Lipidology | 1998 |
Apolipoprotein E and regulation of cytokine-induced cell adhesion molecule expression in endothelial cells
AK Stannard, DR Riddell, NJ Bradley, DG Hassall, A Graham, JS Owen |
Atherosclerosis | 1998 |
Effects of oestrogens and selective oestrogen receptor modulators on serum lipoproteins and vascular function
A Blum, RO Cannon |
Current Opinion in Lipidology | 1998 |
The Biology of Estrogen-Mediated Repair of Cardiovascular Injury
CH MD, TA MD, BD MD, EJ MD, BC MD, AH MD |
The Annals of Thoracic Surgery | 1998 |
Tumor Growth of FGF or VEGF Transfected MCF-7 Breast Carcinoma Cells Correlates with Density of Specific Microvessels Independent of the Transfected Angiogenic Factor
SW McLeskey, CA Tobias, PR Vezza, AC Filie, FG Kern, J Hanfelt |
The American Journal of Pathology | 1998 |
T lymphocytes are not the target for estradiol-mediated suppression of DTH in reconstituted female severe combined immunodeficient (SCID) mice
M Taube, L Svensson, H Carlsten |
Clinical & Experimental Immunology | 1998 |
The oestrogen receptor regulates NFκB and AP-1 activity in a cell-specific manner
G Cerillo, A Rees, N Manchanda, C Reilly, I Brogan, A White, M Needham |
The Journal of Steroid Biochemistry and Molecular Biology | 1998 |
Vascular Surgery
JM FACS |
Journal of the American College of Surgeons | 1998 |
Effect of Iodinated Contrast Media on Neutrophil Adhesion to Cultured Endothelial Cells
PE Thorpe, X Zhan, DK Agrawal |
Journal of Vascular and Interventional Radiology | 1998 |
Leukocyte-endothelium adhesion molecules in atherosclerosis
ZM Dong, DD Wagner |
Journal of Laboratory and Clinical Medicine | 1998 |
Biologic markers as predictors of cardiovascular disease
WH Frishman |
The American Journal of Medicine | 1998 |
Human Umbilical Vein Endothelial Cells Lack Expression of the Estrogen Receptor
I Jensen, CH Rinaldo, LN Berge, OM Seternes, U Moens |
Endothelium : journal of endothelial cell research | 1998 |
Estrogen replacement therapy and cardiovascular protection: Lipid mechanisms are the tip of an iceberg
A Nasr, M Breckwoldt |
Gynecological Endocrinology | 1998 |
Estrogen increases the permeability of the cultured human cervical epithelium by modulating cell deformability
GI Gorodeski |
American journal of physiology. Cell physiology | 1998 |
ESTRADIOL INHIBITS ALLOGRAFT-INDUCIBLE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II ANTIGEN EXPRESSION AND TRANSPLANT ARTERIOSCLEROSIS IN THE ABSENCE OF IMMUNOSUPPRESSION1:
S Saito, ML Foegh, N Motomura, H Lou, K Kent, PW Ramwell |
Transplantation | 1998 |
Increased Expression of Estrogen Receptor-β mRNA in Male Blood Vessels After Vascular Injury
V Lindner, SK Kim, RH Karas, GG Kuiper, JA Gustafsson, ME Mendelsohn |
Circulation research | 1998 |
Soluble Cell Adhesion Molecules in Hypertriglyceridemia and Potential Significance on Monocyte Adhesion
Y Abe, B El-Masri, KT Kimball, H Pownall, CF Reilly, K Osmundsen, CW Smith, CM Ballantyne |
Arteriosclerosis, thrombosis, and vascular biology | 1998 |
17β-Estradiol, Its Metabolites, and Progesterone Inhibit Cardiac Fibroblast Growth
RK Dubey, DG Gillespie, EK Jackson, PJ Keller |
Hypertension | 1998 |
Endocrinology of Cardiovascular Function
ER Levin, JL Nadler |
1998 | |
Absence of P-selectin delays fatty streak formation in mice
RC Johnson, SM Chapman, ZM Dong, JM Ordovas, TN Mayadas, J Herz, RO Hynes, EJ Schaefer, DD Wagner |
Journal of Clinical Investigation | 1997 |
Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice
MD Iafrati, RH Karas, M Aronovitz, S Kim, TR Sullivan, DB Lubahn, TF O'Donnell, KS Korach, ME Mendelsohn |
Nature Medicine | 1997 |
ESTROGENS AND ATHEROSCLEROSIS
LN and, G Chaudhuri |
Annual Review of Pharmacology and Toxicology | 1997 |
Chronic Estrogen Replacement Inhibits Aortic Intimal Hyperplasia Independent of Serum Lipids
CH Selzman, AS Turner, SM Johnson, BS Cain, AH Harken, TA Whitehill |
Journal of Cardiac Surgery | 1997 |
Effects of Hormone Therapy on Inflammatory Cell Adhesion Molecules in Postmenopausal Healthy Women
KK MD, MN MD, RM RN, RO MD |
The American Journal of Cardiology | 1997 |
17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization
T Caulin-Glaser, G García-Cardeña, P Sarrel, WC Sessa, JR Bender |
Circulation research | 1997 |
Human Umbilical Vessels and Cultured Umbilical Vein Endothelial and Smooth Muscle Cells Lack Detectable Protein and mRNA Endocing Estrogen Receptors
VL Baker, VA Chao, JT Murai, CJ Zaloudek, RN Taylor |
Journal of the Society for Gynecologic Investigation | 1997 |
The 27-kDa Heat Shock Protein Facilitates Basic Fibroblast Growth Factor Release from Endothelial Cells
RS Piotrowicz, JL Martin, WH Dillman, EG Levin |
The Journal of biological chemistry | 1997 |
Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones
JR Lancaster, JF Parkinson |
1997 | |
Biphasic estrogen response on bovine adrenal medulla capillary endothelial cell adhesion, proliferation and tube formation
S K Banerjee, D R Campbell, A P Weston, D K Banerjee |
Molecular and Cellular Biochemistry | 1997 |
Multiple Risk Factors in Cardiovascular Disease
AM Gotto, C Lenfant, AL Catapano, R Paoletti |
1995 |