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Citations to this article

Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels.
S Zhong, … , J D Curb, A R Tall
S Zhong, … , J D Curb, A R Tall
Published June 15, 1996
Citation Information: J Clin Invest. 1996;97(12):2917-2923. https://doi.org/10.1172/JCI118751.
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Research Article Article has an altmetric score of 11

Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels.

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Abstract

Plasma high density lipoprotein (HDL) levels are strongly genetically determined and show a general inverse relationship with coronary heart disease (CHD). The cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from HDL to other lipoproteins and is a key participant in the reverse transport of cholesterol from the periphery to the liver. A high prevalence of two different CETP gene mutations (D442G, 5.1%; intron 14G:A, 0.5%), was found in 3,469 men of Japanese ancestry in the Honolulu Heart Program and mutations were associated with decreased CETP (-35%) and increased HDL chol levels (+10% for D442G). However, the overall prevalence of definite CHD was 21% in men with mutations and 16% in men without mutations. The relative risk (RR) of CHD was 1.43 in men with mutations (P < .05); after adjustment for CHD risk factors, the RR was 1.55 (P = .02); after additional adjustment for HDL levels, the RR was 1.68 (P = .008). Similar RR values were obtained for the D442G mutation alone. Increased CHD in men with mutations was primarily observed for HDL chol 41-60 mg/dl; for HDL chol > 60 mg/dl men with and without mutations had low CHD prevalence. Thus, genetic CETP deficiency appears to be an independent risk factor for CHD, primarily due to increased CHD prevalence in men with the D442G mutation and HDL cholesterol between 41 and 60 mg/dl. The findings suggest that both HDL concentration and the dynamics of cholesterol transport through HDL (i.e., reverse cholesterol transport) determine the anti-atherogenicity of the HDL fraction.

Authors

S Zhong, D S Sharp, J S Grove, C Bruce, K Yano, J D Curb, A R Tall

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Citations to this article in year 2007 (20)

Title and authors Publication Year
Drug designed to raise HDL levels falls down
Karen Honey
Journal of Clinical Investigation 2007
Familial occurrence of abnormalities of high-density lipoprotein cholesterol
BG Kral, DM Becker
Journal of Clinical Lipidology 2007
The conscientious judgement of a DSMB – statistical stopping rules re-examined
K Hedenmalm, H Melander, G Alvan
European Journal of Clinical Pharmacology 2007
Scavenger receptor class B type I polymorphisms and peripheral arterial disease
A Ritsch, G Sonderegger, A Sandhofer, U Stanzl, I Tancevski, P Eller, W Schgoer, A Wehinger, T Mueller, M Haltmayer, JR Patsch
Metabolism 2007
Investigational drugs targeting HDL-C metabolism and reverse cholesterol transport
JG Robinson, MH Davidson
Future Lipidology 2007
Inconsistencies in the genetic prediction of HDL cholesterol versus atherosclerosis
J Carlquist, JL Anderson
Current Opinion in Cardiology 2007
High-density lipoprotein mass, cholesteryl ester transport protein, and macrophage reverse cholesterol transport: from the bedside back to the bench
Y Levy
Cardiovascular Research 2007
Intrinsic enzymes of high-density lipoprotein
NA Le, MF Walter
Journal of Clinical Lipidology 2007
Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease?
JA Hamilton, RJ Deckelbaum
Nature Structural & Molecular Biology 2007
Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats
VL Herrera, LR Ponce, N Ruiz-Opazo
Journal of Hypertension 2007
Human Cholestryl Ester Transfer Protein (TaqIB) Polymorphism among Filipinos with Cardiovascular Risk Factors
RG Sy, EM Cutiongco, FE Punzalan, RS Santos, FR Geronimo, RV Tangco
Journal of Atherosclerosis and Thrombosis 2007
Sex differences in the relation of HDL cholesterol to progression of carotid intima-media thickness: The Los Angeles Atherosclerosis Study
AZ Fan, JH Dwyer
Atherosclerosis 2007
Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies
R Krishna, MS Anderson, AJ Bergman, B Jin, M Fallon, J Cote, K Rosko, C Chavez-Eng, R Lutz, DM Bloomfield, M Gutierrez, J Doherty, F Bieberdorf, J Chodakewitz, KM Gottesdiener, JA Wagner
The Lancet 2007
Partial suppression of CETP activity beneficially modifies the lipid transfer profile of plasma
RE Morton, DJ Greene
Atherosclerosis 2007
HDL Cholesterol: Physiology, Pathophysiology, and Management
JJ Link, A Rohatgi, JA de Lemos
Current Problems in Cardiology 2007
Inconsistencies in the genetic prediction of HDL cholesterol versus atherosclerosis:
J Carlquist, JL Anderson
Current Opinion in Cardiology 2007
Cholesterol ester transfer protein (CETP) and atherosclerosis
D Polk, PK Shah
Drug Discovery Today: Therapeutic Strategies 2007
The strange case of Dr HDL and Mr HDL: Does a NO’s story illuminate the mystery of HDL’s dark side uncovered by Dr HDL’s drug targeting CETP?
P Duriez, R Bordet, P Berthelot
Medical Hypotheses 2007
Comprehensive Management of High Risk Cardiovascular Patients
N Kopyt
Comprehensive Management of High Risk Cardiovascular Patients 2007
High‐Density Lipoproteins: From Basic Biology to Clinical Aspects
CJ Fielding
2007

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