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Citations to this article

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
Myron I. Cybulsky, … , Philip W. Connelly, David S. Milstone
Myron I. Cybulsky, … , Philip W. Connelly, David S. Milstone
Published May 15, 2001
Citation Information: J Clin Invest. 2001;107(10):1255-1262. https://doi.org/10.1172/JCI11871.
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A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

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Abstract

VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that may participate in atherogenesis by promoting monocyte accumulation in the arterial intima. Both are expressed in regions predisposed to atherosclerosis and at the periphery of established lesions, while ICAM-1 is also expressed more broadly. To evaluate functions of VCAM-1 in chronic disease, we disrupted its fourth Ig domain, producing the murine Vcam1D4D allele. VCAM-1D4D mRNA and protein were reduced to 2–8% of wild-type allele (Vcam1+) levels but were sufficient to partially rescue the lethal phenotype of VCAM-1–null embryos. After crossing into the LDL receptor–null background, Vcam1+/+ and Vcam1D4D/D4D paired littermates were generated from heterozygous intercrosses and fed a cholesterol-enriched diet for 8 weeks. The area of early atherosclerotic lesions in the aorta, quantified by en face oil red O staining, was reduced significantly in Vcam1D4D/D4D mice, although cholesterol levels, lipoprotein profiles, and numbers of circulating leukocytes were comparable to wild-type. In contrast, deficiency of ICAM-1 either alone or in combination with VCAM-1 deficiency did not alter nascent lesion formation. Therefore, although expression of both VCAM-1 and ICAM-1 is upregulated in atherosclerotic lesions, our data indicate that VCAM-1 plays a dominant role in the initiation of atherosclerosis.

Authors

Myron I. Cybulsky, Kaeko Iiyama, Hongmei Li, Suning Zhu, Mian Chen, Motoi Iiyama, Vannessa Davis, Jose-Carlos Gutierrez-Ramos, Philip W. Connelly, David S. Milstone

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Saudi Pharmaceutical Journal 2020
A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization
R Bourgeois, A Girard, N Perrot, J Guertin, PL Mitchell, C Couture, C Gotti, S Bourassa, P Poggio, E Mass, R Capoulade, CA Scipione, AA Després, P Couture, A Droit, P Pibarot, MB Boffa, S Thériault, ML Koschinsky, P Mathieu, BJ Arsenault
2020
Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
MC Tung, YW Lan, HH Li, HL Chen, SY Chen, YH Chen, CC Lin, MY Tu, CM Chen
Scientific Reports 2020
Rosuvastatin Prevents the Exacerbation of Atherosclerosis in Ligature-Induced Periodontal Disease Mouse Model
JS Suh, SH Lee, Z Fouladian, JY Lee, T Kim, MK Kang, AJ Lusis, KI Boström, RH Kim, NH Park
Scientific Reports 2020
VCAM-1 Target in Non-Invasive Imaging for the Detection of Atherosclerotic Plaques
K Thayse, N Kindt, S Laurent, S Carlier
Biology : open access journal 2020
Targeting Dysfunctional Vascular Endothelial Cells Using Immunoliposomes Under Flow Conditions
M Kheradmandi, I Ackers, MM Burdick, R Malgor, AM Farnoud
Cellular and Molecular Bioengineering 2020
Preoperative soluble VCAM ‐1 contributes to predict late mortality after coronary artery surgery
R Corbalan, M Garcia, L GarridoOlivares, L Garcia, G Perez, R Mellado, R Zalaquett, M Chiong, J Quitral, S Lavandero
Clinical Cardiology 2020
An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes
AA Hernandez, GA Foster, SR Soderberg, A Fernandez, MB Reynolds, MK Orser, KA Bailey, JH Rogers, GD Singh, H Wu, AG Passerini, SI Simon
Journal of immunology (Baltimore, Md. : 1950) 2020
Fluid shear stress modulates endothelial inflammation by targeting LIMS2
J Wang, S Zhang
Experimental biology and medicine (Maywood, N.J.) 2020
Apolipoprotein E knockout rabbit model of intracranial atherosclerotic disease
MS Zabriskie, C Wang, S Wang, MD Alexander
2020
Maternal exposure to soy diet reduces atheroma in hyperlipidemic F1 offspring mice by promoting macrophage and T cell anti-inflammatory responses
RL Burris, SC Vick, B Popovic, PE Fraungruber, S Nagarajan
Atherosclerosis 2020
A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium
L Zhou, H Ning, H Wei, T Xu, X Zhao, A Fu, Q Qian, Z Yang, X Dou, S Li, FJ L.
Oxidative Medicine & Cellular Longevity 2020
Hospitalization With Major Infection and Incidence of End-Stage Renal Disease: The Atherosclerosis Risk in Communities (ARIC) Study
J Ishigami, LT Cowan, RT Demmer, ME Grams, PL Lutsey, J Coresh, K Matsushita
Mayo Clinic Proceedings 2020
Effects of coal-fired PM2.5 on the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoE−/− mice
S Wang, F Wang, L Yang, Q Li, Y Huang, Z Cheng, H Chu, Y Song, L Shang, W Hao, X Wei
BMC Pharmacology and Toxicology 2020
A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction
LW Chen, MC Tsai, CY Chern, TP Tsao, FY Lin, SJ Chen, PF Tsui, YW Liu, HJ Lu, WL Wu, WS Lin, CS Tsai, CS Lin
British Journal of Pharmacology 2020
Calcium Kidney Stones are Associated with Increased Risk of Carotid Atherosclerosis: The Link between Urinary Stone Risks, Carotid Intima-Media Thickness, and Oxidative Stress Markers
HS Huang, PC Liao, CJ Liu
Journal of Clinical Medicine 2020
Mixed Lineage Kinase Domain-Like Protein Promotes Human Monocyte Cell Adhesion to Human Umbilical Vein Endothelial Cells Via Upregulation of Intercellular Adhesion Molecule-1 Expression
F Cai, JL Wang, YL Wu, YW Hu, Q Wang
Medical science monitor : international medical journal of experimental and clinical research 2020
Knockdown of Long Noncoding RNA (lncRNA) AK094457 Relieved Angiotensin II Induced Vascular Endothelial Cell Injury
JY Xu, Y Sun, J Lu
Medical science monitor : international medical journal of experimental and clinical research 2020
Inflammation in Coronary Atherosclerosis and Its Therapeutic Implications
N Montarello, M Nguyen, D Wong, S Nicholls, P Psaltis
Cardiovascular Drugs and Therapy 2020
Inflammation as a Therapeutic Target in Atherosclerosis
MT Nguyen, S Fernando, N Schwarz, JT Tan, CA Bursill, PJ Psaltis
Journal of Clinical Medicine 2019
Immunobiology of Atherosclerosis: A Complex Net of Interactions
HF, GB, SC, GG
International journal of molecular sciences 2019
Salidroside prevents tumor necrosis factor‑α‑induced vascular inflammation by blocking mitogen‑activated protein kinase and NF‑κB signaling activation
R Li, Z Dong, X Zhuang, R Liu, F Yan, Y Chen, X Gao, H Shi
Experimental and therapeutic medicine 2019
Downregulation of GATA6 in mTOR-inhibited human aortic endothelial cells: effects on TNF-α-induced VCAM-1 expression and monocytic cell adhesion
X Fan, X Chen, Q Feng, K Peng, Q Wu, AG Passerini, SI Simon, CX Sun
American journal of physiology. Heart and circulatory physiology 2019
Skeletal Muscle-specific PGC-1α Overexpression Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice
Y Shimba, H Togawa, N Senoo, M Ikeda, N Miyoshi, A Morita, S Miura
Scientific Reports 2019
A Pilot, Randomized Study in Women of Nutrition-Related Clinical Chemistry at 6 Weeks after Roux en Y Gastric Bypass: Comparison of Two Nutrition Support Plans
RA DiSilvestro, P Choban, FN Aguila, M Miller, E Joseph
Obesity Surgery 2019
Radionuclide imaging of inflammation in atherosclerotic vascular disease among people living with HIV infection: current practice and future perspective
IO Lawal, AO Ankrah, AC Stoltz, MM Sathekge
2019
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
LM Tsujikawa, L Fu, S Das, C Halliday, BD Rakai, SC Stotz, CD Sarsons, D Gilham, E Daze, S Wasiak, D Studer, KD Rinker, M Sweeney, JO Johansson, NC Wong, E Kulikowski
Clinical Epigenetics 2019
Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE -/- Mice by Reducing the Inflammatory Response
Y Chai, Z Yin, Q Fan, Z Zhang, K Ye, Y Xu, W Xiao, X Chai, T Zhu, H Nie
Evidence-Based Complementary and Alternative Medicine 2019
Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects promote endothelial inflammation following a high fat meal
A Rajamani, K Borkowski, S Akre, A Fernandez, JW Newman, SI Simon, AG Passerini
Scientific Reports 2019
Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3
T Iwashima, Y Kudome, Y Kishimoto, E Saita, M Tanaka, C Taguchi, S Hirakawa, N Mitani, K Kondo, K Iida
Food & Nutrition Research 2019
Model Placental Barrier Phenotypic Response to Fluoxetine and Sertraline: A Comparative Study
N Arumugasaamy, A Gudelsky, A HurleyNovatny, PC Kim, JP Fisher
Advanced Healthcare Materials 2019
Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders
MH Farzaei, AK Singh, R Kumar, CR Croley, AK Pandey, E Coy-Barrera, JK Patra, G Das, RG Kerry, G Annunziata, GC Tenore, H Khan, M Micucci, R Budriesi, S Momtaz, SM Nabavi, A Bishayee
International journal of molecular sciences 2019
Role of Platelet Mitochondria: Life in a Nucleus-Free Zone
H Melchinger, K Jain, T Tyagi, J Hwa
Frontiers in Cardiovascular Medicine 2019
Genetic and Functional Variants Analysis of the GATA6 Gene Promoter in Acute Myocardial Infarction
Z Sun, S Pang, Y Cui, B Yan
Frontiers in Genetics 2019
Vascular Macrophages in Atherosclerosis
H Xu, J Jiang, W Chen, W Li, Z Chen
Journal of Immunology Research 2019
Genital Chlamydia infection in hyperlipidemic mouse models exacerbates atherosclerosis
UM Nagarajan, JD Sikes, RL Burris, R Jha, B Popovic, P Fraungruber, L Hennings, CL Haggerty, S Nagarajan
Atherosclerosis 2019
Testosterone replacement therapy and cardiovascular risk.
Gagliano-Jucá T, Basaria S
Nature reviews. Cardiology 2019
Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions
Elizabeth D Crane, Ali A. Al-Hashimi, Jack Chen, Edward G. Lynn, Kevin D Won, Šárka Lhotak, Magda Naeim, Khrystyna Platko, Paul Lebeau, Jae Hyun Byun, Bobby Shayegan, Katey Rayner, Joan Krepinsky, Serena Marchiò, Renata Pasqualini, Wadih Arap, Richard C. Austin
JCI Insight 2018
CD163+ Macrophages Promote Angiogenesis, Vascular Permeability, and Inflammation in Atherosclerosis
Liang Guo, Hirokuni Akahori, Emanuel Harari, Samantha Smith, Rohini Polavarapu, Vinit Karmali, Fumiyuki Otsuka, Rachel Gannon, Ryan Braumann, Megan Dickinson, Anuj Gupta, Audrey Jenkins, Michael Lipinski, Johoon Kim, Peter Chhour, Paul de Vries, Hiroyuki Jinnouchi, Robert Kutys, Hiroyoshi Mori, Matthew Kutyna, Sho Torii, Atsushi Sakamoto, Cheol Ung Choi, Qi Cheng, Megan Grove, Mariem Sawan, Yin Zhang, Yihai Cao, Frank Kolodgie, David Peter Cormode, Dan Arking, Eric Boerwinkle, Alanna Morrison, Jeanette Erdmann, Nona Sotoodehnia, Renu Virmani, Aloke Finn
Journal of Clinical Investigation 2018
Beyond the Foam Cell: The Role of LXRs in Preventing Atherogenesis
A Rasheed, C Cummins
International journal of molecular sciences 2018
Piper sarmentosum attenuates TNF-α-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells
SM Ismail, UM Sundar, CK Hui, A Aminuddin, A Ugusman
Journal of Taibah University Medical Sciences 2018
CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation
S Piao, JW Lee, H Nagar, S Jung, S Choi, S Kim, I Lee, S Kim, N Shin, YR Lee, SD Lee, JB Park, K Irani, M Won, GM Hur, BH Jeon, DW Kim, CS Kim, R Ramchandran
PloS one 2018
Hepatocyte estrogen receptor alpha mediates estrogen action to promote reverse cholesterol transport during Western-type diet feeding
L Zhu, J Shi, TN Luu, JC Neuman, E Trefts, S Yu, BT Palmisano, DH Wasserman, MR Linton, JM Stafford
Molecular Metabolism 2018
The Role of Endoplasmic Reticulum Stress-Glycogen Synthase Kinase-3 Signaling in Atherogenesis
A Huang, S Patel, C McAlpine, G Werstuck
International journal of molecular sciences 2018
The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis
PL Gordts, JD Esko
Matrix biology : journal of the International Society for Matrix Biology 2018
Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene
L Russo, HT Muturi, HE Ghadieh, AM Wisniewski, EE Morgan, SS Quadri, GP Landesberg, HM Siragy, G Vazquez, R Scalia, R Gupta, SM Najjar
Molecular Metabolism 2018
Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain
RA Srivastava, JA Cornicelli, B Markham, CL Bisgaier
Frontiers in pharmacology 2018
Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression
Y Li, S Huang, X Huang, X Li, A Falcon, A Soutar, F Bornancin, Z Jiang, HB Xin, M Fu
Cellular Signalling 2018
Dietary inflammatory index: a potent association with cardiovascular risk factors among patients candidate for coronary artery bypass grafting (CABG) surgery
MA Farhangi, M Najafi
Nutrition Journal 2018
Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin α4β1
DG Woodside, EA Tanifum, KB Ghaghada, RJ Biediger, AR Caivano, ZA Starosolski, S Khounlo, S Bhayana, S Abbasi, JW Craft, DS Maxwell, C Patel, IV Stupin, D Bakthavatsalam, RV Market, JT Willerson, RA Dixon, P Vanderslice, AV Annapragada
Scientific Reports 2018
Protective Role of Antioxidant Huskless Barley Extracts on TNF- α -Induced Endothelial Dysfunction in Human Vascular Endothelial Cells
Z Liao, H Cai, Z Xu, J Wang, C Qiu, J Xie, W Huang, Z Sui
Oxidative medicine and cellular longevity 2018
Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism
RA Srivastava, JA Cornicelli, B Markham, CL Bisgaier
Molecular and Cellular Biochemistry 2018
7-Ketocholesterol enhances leukocyte adhesion to endothelial cells via p38MAPK pathway
M Tani, Y Kamata, M Deushi, M Osaka, M Yoshida, P Mukhopadhyay
PloS one 2018
The Endocannabinoid System and Heart Disease: The Role of Cannabinoid Receptor Type 2
ML Fulmer, DP Thewke
Cardiovascular & hematological disorders drug targets 2018
Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity
P Mury, EN Chirico, M Mura, A Millon, E Canet-Soulas, V Pialoux
Sports Medicine 2018
Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model
K Kasahara, KA Krautkramer, E Org, KA Romano, RL Kerby, EI Vivas, M Mehrabian, JM Denu, F Bäckhed, AJ Lusis, FE Rey
Nature Microbiology 2018
TNF-α-Induced YAP/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells
HJ Choi, NE Kim, B Kim, M Seo, J Heo
International journal of molecular sciences 2018
Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort
SP Bhatt, HP Nath, Y Kim, R Ramachandran, JR Watts, NL Terry, S Sonavane, SP Deshmane, PG Woodruff, EC Oelsner, S Bodduluri, ML Han, WW Labaki, JM Wells, FJ Martinez, RG Barr, MT Dransfield
Respiratory Research 2018
Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis
AM Barron, JC Mantero, JD Ho, B Nazari, KL Horback, J Bhawan, R Lafyatis, C Lam, JL Browning
Journal of immunology (Baltimore, Md. : 1950) 2018
Endothelium-derived extracellular vesicles promote splenic monocyte mobilisation in myocardial infarction
Naveed Akbar, Janet Digby, Thomas J. Cahill, Abhijeet Tavare, Alastair Corbin, Sushant Saluja, Sam Dawkins, Laurienne Edgar, Nadia Rawlings, Klemen Ziberna, Eileen McNeill, Oxford Acute Myocardial Infarction (OxAMI) Study, Errin Johnson, Alaa A. Aljabali, Rebecca R. Dragovic, Mala Rohling, T. Grant Belgard, Irina A Udalova, David R. Greaves, Keith Channon, Paul Riley, Daniel C Anthony, Robin Choudhury
JCI Insight 2017
EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis
AC Finney, SD Funk, JM Green, A Yurdagul, MA Rana, R Pistorius, M Henry, A Yurochko, CB Pattillo, JG Traylor, J Chen, MD Woolard, CG Kevil, AW Orr
Circulation 2017
Cytokine-induced autophagy promotes long-term VCAM-1 but not ICAM-1 expression by degrading late-phase IκBα
LY Chu, YC Hsueh, HL Cheng, KK Wu
Scientific Reports 2017
The inhibitory effects of polysaccharide peptides (PsP) of Ganoderma lucidum against atherosclerosis in rats with dyslipidemia
TA Wihastuti, T Heriansyah
Heart International 2017
Integrin signaling in atherosclerosis
AC Finney, KY Stokes, CB Pattillo, AW Orr
Cellular and Molecular Life Sciences 2017
Tryptophan depletion under conditions that imitate insulin resistance enhances fatty acid oxidation and induces endothelial dysfunction through reactive oxygen species-dependent and independent pathways
T Eleftheriadis, G Pissas, M Sounidaki, G Antoniadi, C Rountas, V Liakopoulos, loannis Stefanidis
Molecular and Cellular Biochemistry 2017
Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease
AC Boese, SC Kim, KJ Yin, JP Lee, MH Hamblin
American journal of physiology. Heart and circulatory physiology 2017
Bilirubin Prevents Atherosclerotic Lesion Formation in Low‐Density Lipoprotein Receptor‐Deficient Mice by Inhibiting Endothelial VCAM‐1 and ICAM‐1 Signaling
ME Vogel, G Idelman, ES Konaniah, SD Zucker
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2017
Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36
R Cortese, A Gileles-Hillel, A Khalyfa, I Almendros, M Akbarpour, AA Khalyfa, Z Qiao, T Garcia, J Andrade, D Gozal
Scientific Reports 2017
Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease
MD Shapiro, S Fazio
F1000Research 2017
NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis
A Lozhkin, AE Vendrov, H Pan, SA Wickline, NR Madamanchi, MS Runge
Journal of Molecular and Cellular Cardiology 2017
Ig-like domain 6 of VCAM-1 is a potential therapeutic target in TNFα-induced angiogenesis
TK Kim, CS Park, HJ Na, K Lee, A Yoon, J Chung, S Lee
Experimental & molecular medicine 2017
MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO)
JM Chan, MS Cheung, RG Gibbs, KK Bhakoo
Clinical and Translational Medicine 2017
Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models
DP Jones, HD True, J Patel
Mediators of Inflammation 2017
Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population
YM Feng, L Thijs, ZY Zhang, WY Yang, QF Huang, FF Wei, T Kuznetsova, AM Jennings, C Delles, R Lennox, P Verhamme, A Dominiczak, JA Staessen
Nephrology Dialysis Transplantation 2017
Modified citrus pectin inhibits galectin-3 function to reduce atherosclerotic lesions in apoE-deficient mice
Y Lu, M Zhang, P Zhao, M Jia, B Liu, Q Jia, J Guo, L Dou, J Li
Molecular medicine reports 2017
DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12–CXCR4 signaling axis
AH Chang, BC Raftrey, G D'Amato, VN Surya, A Poduri, HI Chen, AB Goldstone, J Woo, GG Fuller, AR Dunn, K Red-Horse
Genes & development 2017
Notch4 signaling pathway in a Kawasaki disease mouse model induced by Lactobacillus casei cell wall extract
L Gao, S Fu, W Wang, C Xie, Y Zhang, F Gong
Experimental and therapeutic medicine 2017
Ghrelin suppresses inflammation in HUVECs by inhibiting ubiquitin-mediated uncoupling protein 2 degradation
R Zhang
International journal of molecular medicine 2017
Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages
H Rizwan, J Mohanta, S Si, A Pal
International Journal of Nanomedicine 2017
Epidemiology and clinical characteristics of sarcoidosis: an update from a population-based cohort study from Olmsted County, Minnesota
P Ungprasert, CS Crowson, EL Matteson
Reumatismo 2017
Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation
K Buscher, P Marcovecchio, CC Hedrick, K Ley
Frontiers in Cardiovascular Medicine 2017
Exogenous Insulin Infusion Can Decrease Atherosclerosis in Diabetic Rodents by Improving Lipids, Inflammation, and Endothelial FunctionHighlights
K Park, Q Li, ND Evcimen, C Rask-Madsen, Y Maeda, E Maddaloni, H Yokomizo, T Shinjo, R St-Louis, J Fu, D Gordin, M Khamaisi, D Pober, H Keenan, GL King
Arteriosclerosis, thrombosis, and vascular biology 2017
PM2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids
L Guan, X Geng, J Shen, J Yip, F Li, H Du, Z Ji, Y Ding
Oncotarget 2017
Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E −/− MiceHighlights
P Rinne, JJ Kadiri, M Velasco-Delgado, S Nuutinen, M Viitala, M Hollmén, M Rami, E Savontaus, S Steffens
Arteriosclerosis, thrombosis, and vascular biology 2017
Increased Risk of Multimorbidity in Patients With Sarcoidosis: A Population-Based Cohort Study 1976 to 2013
P Ungprasert, EL Matteson, CS Crowson
Mayo Clinic Proceedings 2017
Inflammation-regulated mRNA stability and the progression of vascular inflammatory diseases
AB Herman, MV Autieri
Clinical Science 2017
Insulin decreases atherosclerosis by inducing endothelin receptor B expression
Kyoungmin Park, Akira Mima, Qian Li, Christian Rask-Madsen, Pingnian He, Koji Mizutani, Sayaka Katagiri, Yasutaka Maeda, I-Hsien Wu, Mogher Khamaisi, Simone Rørdam Preil, Ernesto Maddaloni, Ditte Sorensen, Lars Melholt Rasmussen, Paul L. Huang, George Liang King
JCI Insight 2016
Atherogenesis: hyperhomocysteinemia interactions with LDL, macrophage function, paraoxonase 1, and exercise: HHcy in atherogenesis
I Chernyavskiy, S Veeranki, U Sen, SC Tyagi
Annals of the New York Academy of Sciences 2016
Detection and treatment of atherosclerosis using nanoparticles: Detection and treatment of atherosclerosis using nanoparticles
J Zhang, Y Zu, CS Dhanasekara, J Li, D Wu, Z Fan, S Wang
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology 2016
Atherosclerotic cardiovascular disease: a review of initiators and protective factors
MS Ellulu, I Patimah, H Khazaai, A Rahmat, Y Abed, F Ali
Inflammopharmacology 2016
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
MA Gimbrone, G García-Cardeña
Circulation research 2016
Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing
JL Rukov, E Gravesen, ML Mace, J Hofman-Bang, J Vinther, CB Andersen, E Lewin, K Olgaard
American journal of physiology. Renal physiology 2016
Aortic VCAM-1: an early marker of vascular inflammation in collagen-induced arthritis
A Denys, G Clavel, D Lemeiter, O Schischmanoff, MC Boissier, L Semerano
Journal of Cellular and Molecular Medicine 2016
High glucose and palmitate increases bone morphogenic protein 4 expression in human endothelial cells
OK Hong, SJ Yoo, JW Son, MK Kim, KH Baek, KH Song, BY Cha, H Jo, HS Kwon
The Korean Journal of Physiology & Pharmacology 2016
Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex
A Ruan, NH Tobin, K Mulligan, A Rollie, F Li, J Sleasman, GM Aldrovandi
Journal of acquired immune deficiency syndromes (1999) 2016
Caffeic acid phenethyl ester suppresses monocyte adhesion to the endothelium by inhibiting NF-κB/NOX2-derived ROS signaling
R Nakahara, J Makino, T Kamiya, H Hara, T Adachi
Journal of Clinical Biochemistry and Nutrition 2016
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
HB Sager, P Dutta, JE Dahlman, M Hulsmans, G Courties, Y Sun, T Heidt, C Vinegoni, A Borodovsky, K Fitzgerald, GR Wojtkiewicz, Y Iwamoto, B Tricot, OF Khan, KJ Kauffman, Y Xing, TE Shaw, P Libby, R Langer, R Weissleder, FK Swirski, DG Anderson, M Nahrendorf
Science Translational Medicine 2016
Deletion of P2Y2 receptor reveals a role for lymphotoxin-α in fatty streak formation
S Qian, A Hoggatt, YL Jones-Hall, CF Ware, P Herring, CI Seye
Vascular Pharmacology 2016
Increased alpha-defensin expression is associated with risk of coronary heart disease: a feasible predictive inflammatory biomarker of coronary heart disease in hyperlipidemia patients
Y Maneerat, K Prasongsukarn, S Benjathummarak, W Dechkhajorn, U Chaisri
Lipids in Health and Disease 2016
Ulmus davidiana ethanol extract inhibits monocyte adhesion to tumor necrosis factor-alpha-stimulated endothelial cells
KM Lee, HK Joo, YR Lee, MS Park, G Kang, S Choi, KH Lee, BH Jeon
Integrative Medicine Research 2016
Inhibition of Low-Grade Inflammation by Anthocyanins after Microbial Fermentation in Vitro
S Kuntz, C Kunz, E Domann, N Würdemann, F Unger, A Römpp, S Rudloff
Nutrients 2016
Exenatide Alters Gene Expression of NCAM, ICAM, and VCAM in the Hippocampus of Type 2 Diabetic Model Mice
E Gumuslu, N Cine, ME Gökbayrak, O Mutlu, IK Celikyurt, G Ulak
Medical science monitor : international medical journal of experimental and clinical research 2016
Experimental study of USPIO-enhanced MRI in the detection of atherosclerotic plaque and the intervention of atorvastatin
T Sha, C Qi, W Fu, J Hao, L Gong, H Wu, Q Zhang
Experimental and therapeutic medicine 2016
Chinese Herbal Cardiotonic Pill Stabilizes Vulnerable Plaques in Rabbits by Decreasing the Expression of Adhesion Molecules:
L Chen, X Li, C Li, Y Rong, Y Xiao, X Xu, G Yao, G Jiang, M Zhang
Journal of Cardiovascular Pharmacology 2016
Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1Highlights
O Herbin, AG Regelmann, B Ramkhelawon, EG Weinstein, KJ Moore, K Alexandropoulos
Arteriosclerosis, thrombosis, and vascular biology 2016
Cytocompatibility and early inflammatory response of human endothelial cells in direct culture with Mg-Zn-Sr alloys
AF Cipriano, A Sallee, M Tayoba, MC Alcaraz, A Lin, RG Guan, ZY Zhao, H Liu
Acta Biomaterialia 2016
Elevated Levels of Plasma IgA Autoantibodies against Oxidized LDL Found in Proliferative Diabetic Retinopathy but Not in Nonproliferative Retinopathy
S Vavuli, T Salonurmi, S Loukovaara, AE Nissinen, MJ Savolainen, MJ Liinamaa
Journal of Diabetes Research 2016
Risk of cardiovascular disease among patients with sarcoidosis: a population-based retrospective cohort study, 1976–2013
P Ungprasert, CS Crowson, EL Matteson
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2016
Endothelial Cell–Specific Deletion of P2Y 2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null MiceHighlights
X Chen, S Qian, A Hoggatt, H Tang, TA Hacker, AG Obukhov, PB Herring, CI Seye
Arteriosclerosis, thrombosis, and vascular biology 2016
Evaluation of ICAM-1 and VCAM-1 Gene Polymorphisms in Patients with Periodontal Disease.
Wang L, Li XH, Ning WC
Medical science monitor : international medical journal of experimental and clinical research 2016
Atherosclerosis and the role of immune cells
F Ilhan
World journal of clinical cases 2015
Pathogenesis of diabetic cerebral vascular disease complication
RS Xu
World journal of diabetes 2015
Differential Role of an NF-κB Transcriptional Response Element in Endothelial Versus Intimal Cell VCAM-1 ExpressionNovelty and Significance
DS Milstone, M Ilyama, M Chen, P ODonnell, VM Davis, J Plutzky, JD Brown, SM Haldar, A Siu, AC Lau, SN Zhu, MF Basheer, T Collins, J Jongstra-Bilen, MI Cybulsky
Circulation research 2015
Simple modifications to methimazole that enhance its inhibitory effect on tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression by human endothelial cells
A Alapati, SP Deosarkar, OL Lanier, C Qi, GE Carlson, MM Burdick, FL Schwartz, KD McCall, SC Bergmeier, DJ Goetz
European Journal of Pharmacology 2015
PKC-  activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis
MC Durpes, C Morin, J Paquin-Veillet, R Beland, M Pare, MO Guimond, M Rekhter, GL King, P Geraldes
Cardiovascular Research 2015
Nitric Oxide-Enhanced Molecular Imaging of Atheroma using Vascular Cellular Adhesion Molecule 1-Targeted Echogenic Immunoliposomes
H Kim, PH Kee, Y Rim, MR Moody, ME Klegerman, D Vela, SL Huang, DD McPherson, ST Laing
Ultrasound in Medicine & Biology 2015
A novel anti-inflammatory natural product from Sphaeranthus indicus inhibits expression of VCAM1 and ICAM1, and slows atherosclerosis progression independent of lipid changes
RA Srivastava, S Mistry, S Sharma
Nutrition & Metabolism 2015
miR-126 Is Involved in Vascular Remodeling under Laminar Shear Stress
AM Santos, L Metzinger, O Haddad, E M’baya-Moutoula, F Taïbi, N Charnaux, ZA Massy, H Hlawaty, VM Meuth
BioMed Research International 2015
Clopidogrel significantly lowers the development of atherosclerosis in ApoE-deficient mice in vivo
C Heim, J Gebhardt, M Ramsperger-Gleixner, J Jacobi, M Weyand, SM Ensminger
Heart and Vessels 2015
Artery Wall Assessment Helps Predict Kidney Transplant Outcome
D Hernández, J Triñanes, E Salido, S Pitti, M Rufino, JM González-Posada, A Torres, T Shimosawa
PloS one 2015
Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway
X Sha, S Meng, X Li, H Xi, M Maddaloni, DW Pascual, H Shan, X Jiang, H Wang, X Yang
The Journal of biological chemistry 2015
Arsenic Exposure Increases Monocyte Adhesion to the Vascular Endothelium, a Pro-Atherogenic Mechanism
M Lemaire, LF Silva, CA Lemarié, AM Bolt, MF Molina, RM Krohn, JE Smits, S Lehoux, KK Mann, PA da Martins
PloS one 2015
Nuclear Molecular Imaging for Vulnerable Atherosclerotic Plaques
SJ Lee, JC Paeng
Korean Journal of Radiology 2015
Interleukin-27 enhances TNF-α-mediated activation of human coronary artery endothelial cells
HN Qiu, B Liu, W Liu, S Liu
Molecular and Cellular Biochemistry 2015
Inflammation, Endothelial Dysfunction and Increased Left Ventricular Mass in Chronic Kidney Disease (CKD) Patients: A Longitudinal Study
K Ioannou, VS Stel, E Dounousi, KJ Jager, A Papagianni, K Pappas, KC Siamopoulos, C Zoccali, D Tsakiris, C Passino
PloS one 2015
CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia
GA Foster, L Xu, AA Chidambaram, SR Soderberg, EJ Armstrong, H Wu, SI Simon
Journal of immunology (Baltimore, Md. : 1950) 2015
EOLA1 Inhibits Lipopolysaccharide-Induced Vascular Cell Adhesion Molecule-1 Expression by Association with MT2A in ECV304 Cells
W Leng, X Lei, H Meng, X Ouyang, Z Liang
International Journal of Inflammation 2015
Masked hypertension and its associated cardiovascular risk in young individuals: the African-PREDICT study
JE Thompson, W Smith, LJ Ware, CM Mels, JM van Rooyen, HW Huisman, L Malan, NT Malan, L Lammertyn, AE Schutte
Hypertension Research 2015
Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis
RJ Flach, A Skoura, A Matevossian, LV Danai, W Zheng, C Cortes, SK Bhattacharya, M Aouadi, N Hagan, JC Yawe, P Vangala, LG Menendez, MP Cooper, TP Fitzgibbons, L Buckbinder, MP Czech
Nature Communications 2015
Contrast Imaging in Mouse Embryos Using High-frequency Ultrasound
JM Denbeigh, BA Nixon, MC Puri, FS Foster
Journal of visualized experiments : JoVE 2015
Hypoxia-inducible factor-2 in endothelial cells mediates protection and recovery from ischemic kidney injury
Pinelopi Kapitsinou, Hideto Sano, Mark Michael, Hanako Kobayashi, Olena Davidoff, Aihua Bian, Bing Yao, Ming-zhi Zhang, Raymond C. Harris, Kevin Duffy, Connie Erickson-Miller, Timothy Sutton, Volker H. Haase
Journal of Clinical Investigation 2014
Endothelial Cell-Specific ROS Production Increases Susceptibility to Aortic Dissection
LM Fan, G Douglas, JK Bendall, E McNeill, MJ Crabtree, AB Hale, A Mai, JM Li, MA McAteer, JE Schneider, RP Choudhury, KM Channon
Circulation 2014
Periodontitis-activated monocytes/macrophages cause aortic inflammation
SI Miyajima, K Naruse, Y Kobayashi, N Nakamura, T Nishikawa, K Adachi, Y Suzuki, T Kikuchi, A Mitani, M Mizutani, N Ohno, T Noguchi, T Matsubara
Scientific Reports 2014
An abundant dysfunctional apolipoprotein A1 in human atheroma
Y Huang, JA DiDonato, BS Levison, D Schmitt, L Li, Y Wu, J Buffa, T Kim, GS Gerstenecker, X Gu, CS Kadiyala, Z Wang, MK Culley, JE Hazen, AJ DiDonato, X Fu, SZ Berisha, D Peng, TT Nguyen, S Liang, CC Chuang, L Cho, EF Plow, PL Fox, V Gogonea, WH Tang, JS Parks, EA Fisher, JD Smith, SL Hazen
Nature Medicine 2014
Cell adhesion molecules and eNOS expression in aorta of normocholesterolemic mice with different predispositions to atherosclerosis
J Rathouska, I Nemeckova, L Zemankova, Z Strasky, K Jezkova, M Varejckova, P Nachtigal
Heart and Vessels 2014
Nitric Oxide Pretreatment Enhances Atheroma Component Highlighting in Vivo with Intercellular Adhesion Molecule-1-Targeted Echogenic Liposomes
PH Kee, H Kim, S Huang, ST Laing, MR Moody, D Vela, ME Klegerman, DD McPherson
Ultrasound in Medicine & Biology 2014
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
A Schober, M Nazari-Jahantigh, Y Wei, K Bidzhekov, F Gremse, J Grommes, RT Megens, K Heyll, H Noels, M Hristov, S Wang, F Kiessling, EN Olson, C Weber
Nature Medicine 2014
Particulate Matter From Saudi Arabia Induces Genes Involved in Inflammation, Metabolic Syndrome and Atherosclerosis
J Brocato, H Sun, M Shamy, T Kluz, MA Alghamdi, MI Khoder, LC Chen, M Costa
Journal of Toxicology and Environmental Health, Part A 2014
Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations
J Martorell, P Santoma, K Kolandaivelu, VB Kolachalama, P Melgar-Lesmes, JJ Molins, L Garcia, ER Edelman, M Balcells
Cardiovascular Research 2014
The myriad essential roles of microRNAs in cardiovascular homeostasis and disease
RL Neppl, DZ Wang
Genes & Diseases 2014
Molecular magnetic resonance imaging of brain–immune interactions
M Gauberti, A Montagne, AÃ Quenault, D Vivien
Frontiers in cellular neuroscience 2014
Upregulation of ICAM-1 in diabetic rats after transient forebrain ischemia and reperfusion injury
L Jing, JG Wang, JZ Zhang, CX Cao, Y Chang, JD Dong, FY Guo, PA Li
Journal of Inflammation 2014
Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles
CH Kuo, L Leon, EJ Chung, RT Huang, TJ Sontag, CA Reardon, GS Getz, M Tirrell, Y Fang
Journal of Materials Chemistry B 2014
Occlusal disharmony accelerates the initiation of atherosclerosis in apoE knockout rats
D Ekuni, T Yoneda, Y Endo, K Kasuyama, K Irie, S Mizutani, T Azuma, T Tomofuji, M Morita
Lipids in Health and Disease 2014
NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis
JD Brown, CY Lin, Q Duan, G Griffin, AJ Federation, RM Paranal, S Bair, G Newton, AH Lichtman, AL Kung, T Yang, H Wang, FW Luscinskas, KJ Croce, JE Bradner, J Plutzky
Molecular Cell 2014
Functional knock down of VCAM1 in mice mediated by endoplasmatic reticulum retained intrabodies
AL Marschall, FN Single, K Schlarmann, A Bosio, N Strebe, J Heuvel, A Frenzel, S Dübel
mAbs 2014
Cerebral inflammation is an underlying mechanism of early death in Alzheimer’s disease: a 13-year cause-specific multivariate mortality study
K Nägga, C Wattmo, Y Zhang, LO Wahlund, S Palmqvist
Alzheimer's research & therapy 2014
Deletion of Krüppel‐Like Factor 4 in Endothelial and Hematopoietic Cells Enhances Neointimal Formation Following Vascular Injury
T Yoshida, M Yamashita, C Horimai, M Hayashi
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2014
Systemic Delivery of MicroRNA-181b Inhibits Nuclear Factor-κB Activation, Vascular Inflammation, and Atherosclerosis in Apolipoprotein E–Deficient Mice
X Sun, S He, AK Wara, B Icli, E Shvartz, Y Tesmenitsky, N Belkin, D Li, TS Blackwell, GK Sukhova, K Croce, MW Feinberg
Circulation research 2014
Kruppel Like Factor 15 is critical for vascular inflammation
Yuan Lu, Lisheng Zhang, Xudong Liao, Panjamaporn Sangwung, Domenick A. Prosdocimo, Guangjin Zhou, Alexander R. Vortruba, Leigh Brian, Yuh Jung Han, Huiyun Gao, Yunmei Wang, Koichi Shimizu, Kaitlyn Weinert-Stein, Maria Khrestian, Daniel Simon, Neil Freedman, Mukesh Jain
Journal of Clinical Investigation 2013
Mouse models of atherosclerosis: explaining critical roles of lipid metabolism and inflammation
R Mukhopadhyay
Journal of Applied Genetics 2013
Soy protein inhibits inflammation-induced VCAM-1 and inflammatory cytokine induction by inhibiting the NF-κB and AKT signaling pathway in apolipoprotein E–deficient mice
RL Burris, HP Ng, S Nagarajan
European Journal of Nutrition 2013
Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation
Y Zhu, T Shen, Y Lin, B Chen, Y Ruan, Y Cao, Y Qiao, Y Man, S Wang, J Li
Acta Pharmacologica Sinica 2013
The role of the vascular dendritic cell network in atherosclerosis
N Alberts-Grill, TL Denning, A Rezvan, H Jo
American journal of physiology. Cell physiology 2013
The Role of ROS in Ionizing Radiation-Induced VLA-4 Mediated Adhesion of RAW264.7 Cells to VCAM-1 Under Flow Conditions
Y Yuan, SH Lee, S Wu
Radiation Research 2013
Hypoxia in murine atherosclerotic plaques and its adverse effects on macrophages
S Parathath, Y Yang, S Mick, EA Fisher
Trends in Cardiovascular Medicine 2013
IL-17 Induces Expression of Vascular Cell Adhesion Molecule Through Signalling Pathway of NF-κB, but not Akt1 and TAK1 in Vascular Smooth Muscle Cells
H Zhang, J Chen, X Liu, L Awar, A McMickle, F Bai, S Nagarajan, S Yu
Scandinavian Journal of Immunology 2013
High soluble vascular cell adhesion molecule-1 concentrations predict long-term mortality in hemodialysis patients
JF Chang, SP Hsu, MF Pai, JY Yang, HY Chen, HY Wu, YS Peng
International Urology and Nephrology 2013
Pilot study of vascular health in survivors of osteosarcoma: Vascular Health in Survivors of Osteosarcoma
DA Mulrooney, KK Ness, S Huang, A Solovey, RP Hebbel, JD Neaton, DR Clohisy, AS Kelly, JP Neglia
Pediatric Blood & Cancer 2013
Nuclear FAK: a new mode of gene regulation from cellular adhesions
ST Lim
Molecules and Cells 2013
Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity
M Reyman, AA Stuart, M Summeren, M Rakhshandehroo, R Nuboer, FK de Boer, HJ van Ham, E Kalkhoven, B Prakken, HS Schipper
International Journal of Obesity 2013
Ceacam1 deletion causes vascular alterations in large vessels
SM Najjar, KJ Ledford, SL Abdallah, A Paus, L Russo, MK Kaw, SK Ramakrishnan, HT Muturi, CK Raphael, SG Lester, G Heinrich, SV Pierre, R Benndorf, V Kleff, AA Jaffa, E Lévy, G Vazquez, IJ Goldberg, N Beauchemin, R Scalia, S Ergün
American journal of physiology. Endocrinology and metabolism 2013
Genetic mouse models to study blood-brain barrier development and function
F Sohet, R Daneman
Fluids and barriers of the CNS 2013
In vivo molecular imaging of atherosclerotic lesions in ApoE-/- mice using VCAM-1-specific, 99mTc-labeled peptidic sequences
J Dimastromatteo, A Broisat, P Perret, M Ahmadi, D Boturyn, P Dumy, D Fagret, LM Riou, C Ghezzi
Journal of Nuclear Medicine 2013
Endothelial MicroRNAs and Atherosclerosis
X Sun, N Belkin, MW Feinberg
Current Atherosclerosis Reports 2013
Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Induced by Urotensin II in Human Vascular Endothelial Cells
SL Park, BK Lee, YA Kim, BH Lee, YS Jung
Biomolecules and Therapeutics 2013
Beyond Toll-Like Receptors: Porphyromonas gingivalis Induces IL-6, IL-8, and VCAM-1 Expression Through NOD-Mediated NF-κB and ERK Signaling Pathways in Periodontal Fibroblasts
J Liu, Y Wang, X Ouyang
Inflammation 2013
Tumor necrosis factor-alpha-converting enzyme activities and tumor-associated macrophages in breast cancer
SL Rego, RS Helms, D Dréau
Immunologic Research 2013
Diabetes alters the expression of partial vasoactivators in cerebral vascular disease susceptible regions of the diabetic rat
R Xu, R Yang, H Hu, Q Xi, H Wan, Y Wu
Diabetology & metabolic syndrome 2013
Characterization of VCAM-1-binding peptide-functionalized quantum dots for molecular imaging of inflamed endothelium
Y Chen, M Molnár, L Li, P Friberg, LM Gan, H Brismar, Y Fu
PloS one 2013
Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats
KZ Norsidah, AY Asmadi, A Azizi, O Faizah, Y Kamisah
Evidence-Based Complementary and Alternative Medicine 2013
Noninvasive ultrasound molecular imaging of the effect of statins on endothelial inflammatory phenotype in early atherosclerosis
E Khanicheh, M Mitterhuber, L Xu, SP Haeuselmann, GM Kuster, BA Kaufmann
PloS one 2013
The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis
T Samson, JD van Buul, J Kroon, C Welch, EN Bakker, HL Matlung, TK van Berg, L Sharek, C Doerschuk, K Hahn, K Burridge
PloS one 2013
Evidence stacks up that endothelial insulin resistance is a culprit in atherosclerosis
JE Kanter, KE Bornfeldt
Circulation research 2013
Proinflammatory Endothelial Activation Detected by Molecular Imaging in Obese Nonhuman Primates Coincides With Onset of Insulin Resistance and Progressively Increases With Duration of Insulin Resistance
SM Chadderdon, JT Belcik, L Bader, MA Kirigiti, DM Peters, P Kievit, KL Grove, JR Lindner
Circulation 2013
Aberrant regulation of the integrin very late antigen-4 in systemic lupus erythematosus
H Rahimi, K Maurer, L Song, E Akhter, M Petri, K Sullivan
Lupus 2013
Programmable nanoparticle functionalization for in vivo targeting
H Pan, JW Myerson, L Hu, JN Marsh, K Hou, MJ Scott, JS Allen, G Hu, SS Roman, GM Lanza, RD Schreiber, PH Schlesinger, SA Wickline
The FASEB Journal 2013
Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-β Isoform in the Endothelium
Q Li, K Park, C Li, C Rask-Madsen, A Mima, W Qi, K Mizutani, P Huang, GL King
Circulation research 2013
Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune–inflammatory responses in diabetic Apoe −/− mice
ED Marco, SP Gray, P Chew, C Koulis, A Ziegler, C Szyndralewiez, RM Touyz, HH Schmidt, ME Cooper, R Slattery, KA Jandeleit-Dahm
Diabetologia 2013
The Complexity of Arterial Classical Monocyte Recruitment
M Drechsler, O Soehnlein
Journal of Innate Immunity 2013
Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype
L Cardilo-Reis, S Gruber, SM Schreier, M Drechsler, N Papac-Milicevic, C Weber, O Wagner, H Stangl, O Soehnlein, CJ Binder
EMBO Molecular Medicine 2012
Depletion of B2 but Not B1a B Cells in BAFF Receptor-Deficient ApoE−/− Mice Attenuates Atherosclerosis by Potently Ameliorating Arterial Inflammation
T Kyaw, C Tay, H Hosseini, P Kanellakis, T Gadowski, F MacKay, P Tipping, A Bobik, BH Toh
PloS one 2012
Genetic Basis of Atherosclerosis: Insights From Mice and Humans
IM Stylianou, RC Bauer, MP Reilly, DJ Rader, AJ Marian, H Watkins, C Seidman
Circulation research 2012
Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes
SD Funk, A Yurdagul, AW Orr
International Journal of Vascular Medicine 2012
Vascular Injury in Cancer Survivors
DA Mulrooney, AH Blaes, D Duprez
Journal of Cardiovascular Translational Research 2012
Pilot study of vascular health in survivors of Hodgkin lymphoma
DA Mulrooney, KK Ness, A Solovey, RP Hebbel, JD Neaton, BA Peterson, CK Lee, AS Kelly, JP Neglia
Pediatric Blood & Cancer 2012
Chronic Inflammation and Coronary Atherosclerosis in Patients with End-Stage Renal Disease
MB Nusair, N Rajpurohit, MA Alpert
Cardiorenal Medicine 2012
GroEL1, from Chlamydia pneumoniae, Induces Vascular Adhesion Molecule 1 Expression by p37AUF1 in Endothelial Cells and Hypercholesterolemic Rabbit
CY Huang, CM Shih, NW Tsao, YH Chen, CY Li, YJ Chang, NC Chang, KL Ou, CY Lin, YW Lin, CH Nien, FY Lin
PloS one 2012
Effect of palmitic acid and linoleic acid on expression of ICAM-1 and VCAM-1 in human bone marrow endothelial cells (HBMECs)
N Sanadgol, A Mostafaie, K Mansouri, G Bahrami
Archives of Medical Science : AMS 2012
Shape and Compliance of Endothelial Cells after Shear Stress In Vitro or from Different Aortic Regions: Scanning Ion Conductance Microscopy Study
CM Potter, S Schobesberger, MH Lundberg, PD Weinberg, JA Mitchell, J Gorelik
PloS one 2012
Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation
IH Jung, YH Lee, JY Yoo, SJ Jeong, SK Sonn, JG Park, KH Ryu, BY Lee, HY Han, SY Lee, DY Kim, H Lee, GT Oh
Experimental & molecular medicine 2012
De-alcoholised white and red wines decrease inflammatory markers and NF-κB in atheroma plaques in apoE-deficient mice
N Martínez, K Casós, P Simonetti, MP Sáiz, JJ Moreno, MT Mitjavila
European Journal of Nutrition 2012
Therapeutic strategies to deplete macrophages in atherosclerotic plaques
ID Meyer, W Martinet, GR de Meyer
British Journal of Clinical Pharmacology 2012
Inflammatory monocytes and the pathogenesis of viral encephalitis
RL Terry, DR Getts, C Deffrasnes, C Vreden, IL Campbell, NJ King
Journal of Neuroinflammation 2012
Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation
LA Johnson, HS Kim, MJ Knudson, CT Nipp, X Yi, N Maeda
Journal of lipid research 2012
Assessment of biomarkers of cardiovascular risk among HIV type 1-infected adolescents: role of soluble vascular cell adhesion molecule as an early indicator of endothelial inflammation
SS Syed, RS Balluz, EK Kabagambe, WA 3rd, S Lukas, CM Wilson, BG Kapogiannis, SA Nachman, JW Sleasman
AIDS Research and Human Retroviruses 2012
Activation of thromboxane receptor modulates interleukin-1β-induced monocyte adhesion--a novel role of Nox1
H Bayat, K Schröder, DR Pimentel, RP Brandes, TJ Verbeuren, RA Cohen, B Jiang
Free radical biology & medicine 2012
Increased VCAM-1 Expression in Short Duration, Untreated Juvenile Dermatomyositis Muscle Biopsies is Regulated by miR-126
E Kim, J Cook-Mills, G Morgan, ST Sredni, LM Pachman
Arthritis & Rheumatism 2012
C-Peptide: A New Mediator of Atherosclerosis in Diabetes
D Vasic, D Walcher
Mediators of Inflammation 2012
Retinol-Binding Protein 4 Induces Inflammation in Human Endothelial Cells by an NADPH Oxidase- and Nuclear Factor Kappa B-Dependent and Retinol-Independent Mechanism
KM Farjo, RA Farjo, S Halsey, G Moiseyev, J Ma
Molecular and cellular biology 2012
NADPH Oxidase 4 Mediates Monocyte Priming and Accelerated Chemotaxis Induced by Metabolic Stress
S Ullevig, Q Zhao, CF Lee, HS Kim, D Zamora, R Asmis
Arteriosclerosis, thrombosis, and vascular biology 2012
Loss of Id3 Increases VCAM-1 Expression, Macrophage Accumulation, and Atherogenesis in Ldlr–/– Mice
MJ Lipinski, KA Campbell, SQ Duong, TJ Welch, JC Garmey, AC Doran, MD Skaflen, SN Oldham, KA Kelly, CA McNamara
Arteriosclerosis, thrombosis, and vascular biology 2012
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease
Christian Besler, Kathrin Heinrich, Lucia Rohrer, Carola Doerries, Meliana Riwanto, Diana M. Shih, Angeliki Chroni, Keiko Yonekawa, Sokrates Stein, Nicola Schaefer, Maja Mueller, Alexander Akhmedov, Georgios Daniil, Costantina Manes, Christian Templin, Christophe Wyss, Willibald Maier, Felix C. Tanner, Christian M. Matter, Roberto Corti, Clement E. Furlong, Aldons J. Lusis, Arnold von Eckardstein, Alan M. Fogelman, Thomas F. Lüscher, Ulf Landmesser
Journal of Clinical Investigation 2011
Effects of chronic mental stress and atherogenic diet on the immune inflammatory environment in mouse aorta
MC Marcondes, V Zhukov, H Bradlow, M Sanchez-Alavez, AS Gonzalez, LK Curtiss, B Conti
Brain, Behavior, and Immunity 2011
Insulin augments tumor necrosis factor-alpha stimulated expression of vascular cell adhesion molecule-1 in vascular endothelial cells
DZ Mackesy, ML Goalstone
Journal of inflammation (London, England) 2011
Monocyte and Macrophage Dynamics during Atherogenesis
K Ley, YI Miller, CC Hedrick
Arteriosclerosis, thrombosis, and vascular biology 2011
Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives
JJ Chiu, S Chien
Physiological reviews 2011
Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE−/− and LDLR−/− Mice
O Bogachev, A Majdalawieh, X Pan, L Zhang, HS Ro
Molecular Medicine 2011
Repetitive hypoglycaemia increases serum adrenaline and induces monocyte adhesion to the endothelium in rat thoracic aorta
WL Jin, K Azuma, T Mita, H Goto, A Kanazawa, T Shimizu, F Ikeda, Y Fujitani, T Hirose, R Kawamori, H Watada
Diabetologia 2011
Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils
J Zhang, P Alcaide, L Liu, J Sun, A He, FW Luscinskas, GP Shi
PloS one 2011
Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study
EH Wilker, SE Alexeeff, H Suh, PS Vokonas, A Baccarelli, J Schwartz
Environmental health : a global access science source 2011
Changes in the vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and c-reactive protein following administration of aqueous extract of piper sarmentosum on experimental rabbits fed with cholesterol diet
AA Amran, Z Zakaria, F Othman, S Das, HM Al-Mekhlafi, NA Nordin
Lipids in Health and Disease 2011
VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors
X Lu, E Mu, Y Wei, S Riethdorf, Q Yang, M Yuan, J Yan, Y Hua, BJ Tiede, X Lu, BG Haffty, K Pantel, J Massagué, Y Kang
Cancer Cell 2011
Genipin Selectively Inhibits TNF-α-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-γ in Human Endothelial Cells
JS Hwa, L Mun, HJ Kim, HG Seo, JH Lee, JH Kwak, DU Lee, KC Chang
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011
Angiotensin II modulates interleukin-1β-induced inflammatory gene expression in vascular smooth muscle cells via interfering with ERK-NF-κB crosstalk
S Xu, H Zhi, X Hou, B Jiang
Biochemical and Biophysical Research Communications 2011
Redox Signaling in an In Vivo Murine Model of Low Magnitude Oscillatory Wall Shear Stress
NJ Willett, K Kundu, SF Knight, S Dikalov, N Murthy, WR Taylor
Antioxidants & Redox Signaling 2011
CD11c/CD18 Expression Is Upregulated on Blood Monocytes During Hypertriglyceridemia and Enhances Adhesion to Vascular Cell Adhesion Molecule-1
RM Gower, H Wu, GA Foster, S Devaraj, I Jialal, CM Ballantyne, AA Knowlton, SI Simon
Arteriosclerosis, thrombosis, and vascular biology 2011
Inhibition of c-Jun N-Terminal Kinase Attenuates Low Shear Stress-Induced Atherogenesis in Apolipoprotein E-Deficient Mice
J Wang, FS An, W Zhang, L Gong, SJ Wei, WD Qin, XP Wang, YX Zhao, Y Zhang, C Zhang, MX Zhang
Molecular Medicine 2011
Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction.
Heo KS, Fujiwara K, Abe J
Circulation journal : official journal of the Japanese Circulation Society 2011
Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice
P Nigro, K Satoh, MR O'Dell, NN Soe, Z Cui, A Mohan, J Abe, JD Alexis, JD Sparks, BC Berk
Journal of Experimental Medicine 2010
Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE−/− mouse model
SJ White, GB Sala-Newby, AC Newby
Cardiovascular Pathology 2010
Inflammatory and autoimmune reactions in atherosclerosis and vaccine design informatics
M Jan, S Meng, NC Chen, J Mai, H Wang, XF Yang
Journal of biomedicine & biotechnology 2010
Monocytes in atherosclerosis: subsets and functions
KJ Woollard, F Geissmann
Nature reviews. Cardiology 2010
Molecular imaging in atherosclerosis
AW Glaudemans, RH Slart, A Bozzao, E Bonanno, M Arca, RA Dierckx, A Signore
European Journal of Nuclear Medicine and Molecular Imaging 2010
A novel role of CCN3 in regulating endothelial inflammation
Z Lin, V Natesan, H Shi, A Hamik, D Kawanami, C Hao, GH Mahabaleshwar, W Wang, ZG Jin, GB Atkins, SM Firth, L Rittié, B Perbal, MK Jain
Journal of Cell Communication and Signaling 2010
An approach to molecular imaging of atherosclerosis, thrombosis, and vascular inflammation using microparticles of iron oxide
MA McAteer, AM Akhtar, CZ Muhlen, RP Choudhury
Atherosclerosis 2010
Broad regulation of matrix and adhesion molecules in THP-1 human macrophages by nitroglycerin
AS Krishnatry, DA Brazeau, HL Fung
Nitric Oxide 2010
Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs)
S Upadhyay, K Ganguly, T Stoeger, M Semmler-Bhenke, S Takenaka, WG Kreyling, M Pitz, P Reitmeir, A Peters, O Eickelberg, HE Wichmann, H Schulz
Particle and Fibre Toxicology 2010
Insights into atherosclerosis using nanotechnology
A Jayagopal, MF Linton, S Fazio, FR Haselton
Current Atherosclerosis Reports 2010
Pulmonary exposure to carbon black nanoparticles and vascular effects
LK Vesterdal, JK Folkmann, NR Jacobsen, M Sheykhzade, H Wallin, S Loft, P Møller
Particle and Fibre Toxicology 2010
Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
M Arakawa, T Mita, K Azuma, C Ebato, H Goto, T Nomiyama, Y Fujitani, T Hirose, R Kawamori, H Watada
Diabetes 2010
The role of noninvasive imaging in promoting cardiovascular health
V Fuster, TP Vahl
Journal of Nuclear Cardiology 2010
Phosphorylation of p50 NF-κB at a Single Serine Residue by DNA-dependent Protein Kinase Is Critical for VCAM-1 Expression upon TNF Treatment*
J Ju, AS Naura, Y Errami, M Zerfaoui, H Kim, JG Kim, ZY Elmageed, AB Abdel-Mageed, C Giardina, AA Beg, ME Smulson, AH Boulares
The Journal of biological chemistry 2010
Indoxyl Sulfate Induces Leukocyte-Endothelial Interactions through Up-regulation of E-selectin*
S Ito, M Osaka, Y Higuchi, F Nishijima, H Ishii, M Yoshida
The Journal of biological chemistry 2010
11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice
GA Deuchar, D McLean, PW Hadoke, DG Brownstein, DJ Webb, JJ Mullins, K Chapman, JR Seckl, YV Kotelevtsev
Endocrinology 2010
Molecular Imaging of the Initial Inflammatory Response in Atherosclerosis: Implications for Early Detection of Disease
BA Kaufmann, CL Carr, JT Belcik, A Xie, Q Yue, S Chadderdon, ES Caplan, J Khangura, S Bullens, S Bunting, JR Lindner
Arteriosclerosis, thrombosis, and vascular biology 2010
Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study.
Baccarelli A, Tarantini L, Wright RO, Bollati V, Litonjua AA, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J
Epigenetics : official journal of the DNA Methylation Society 2010
A role of matrix metalloproteinase-8 in atherosclerosis
RC Laxton, Y Hu, J Duchene, F Zhang, Z Zhang, KY Leung, Q Xiao, RS Scotland, CP Hodgkinson, K Smith, J Willeit, C López-Otín, IA Simpson, S Kiechl, A Ahluwalia, Q Xu, S Ye
Circulation research 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
The relation of markers of inflammation and endothelial dysfunction to the prevalence and progression of diabetic retinopathy: Wisconsin epidemiologic study of diabetic retinopathy
BE Klein, MD Knudtson, MY Tsai, R Klein
Archives of ophthalmology 2009
Immune and Inflammatory Mechanisms of Atherosclerosis*
E Galkina, K Ley
Annual Review of Immunology 2009
Innate and adaptive immunity in atherosclerosis
RR Packard, AH Lichtman, P Libby
Seminars in Immunopathology 2009
Myeloid cells in atherosclerosis: initiators and decision shapers
O Soehnlein, C Weber
Seminars in Immunopathology 2009
Quantum dot mediated imaging of atherosclerosis
A Jayagopal, YR Su, JL Blakemore, MR Linton, S Fazio, FR Haselton
Nanotechnology 2009
Cardiovascular determinants of life span
Y Shi, GG Camici, TF Lüscher
Pflügers Archiv - European Journal of Physiology 2009
Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis
EL Gautier, C Jakubzick, GJ Randolph
Arteriosclerosis, thrombosis, and vascular biology 2009
Reduction of monocyte chemoattractant protein-1 and interleukin-8 levels by ticlopidine in TNF-alpha stimulated human umbilical vein endothelial cells
CJ Hu, YL Lee, NY Shih, YY Yang, S Charoenfuprasert, YS Dai, SM Chang, YH Tsai, H Tseng, CY Liu, SJ Leu
Journal of biomedicine & biotechnology 2009
Insulin and insulin-like growth factor-I receptors differentially mediate insulin-stimulated adhesion molecule production by endothelial cells
G Li, EJ Barrett, SH Ko, W Cao, Z Liu
Endocrinology 2009
Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline
XF Ming, AG Rajapakse, JM Carvas, J Ruffieux, Z Yang
BMC Cardiovascular Disorders 2009
Molecular imaging in cardiovascular disease: targets and opportunities
SY Shaw
Nature Reviews Cardiology 2009
The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?
AG Pockley, SK Calderwood, G Multhoff
Cell stress & chaperones 2009
The macrophage: the intersection between HIV infection and atherosclerosis
SM Crowe, CL Westhorpe, N Mukhamedova, A Jaworowski, D Sviridov, M Bukrinsky
Journal of leukocyte biology 2009
Functional Role of CD11c + Monocytes in Atherogenesis Associated With Hypercholesterolemia
H Wu, RM Gower, H Wang, XY Perrard, R Ma, DC Bullard, AR Burns, A Paul, CW Smith, SI Simon, CM Ballantyne
Circulation 2009
Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells
C Séguin, MR Abid, KC Spokes, IG Schoots, A Brkovic, MG Sirois, WC Aird
Biomedicine & Pharmacotherapy 2008
Nuclear Receptors and Inflammatory Diseases
K Wang, YJ Wan
Experimental biology and medicine (Maywood, N.J.) 2008
The anti-atherosclerotic effect of olive leaf extract is related to suppressed inflammatory response in rabbits with experimental atherosclerosis
L Wang, C Geng, L Jiang, D Gong, D Liu, H Yoshimura, L Zhong
European Journal of Nutrition 2008
Spatial regulation of inflammation by human aortic endothelial cells in a linear gradient of shear stress
JK Tsou, RM Gower, HJ Ting, UY Schaff, MF Insana, AG Passerini, SI Simon
Microcirculation (New York, N.Y. : 1994) 2008
Quantitative trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice
Z Yuan, Z Su, T Miyoshi, JS Rowlan, W Shi
Molecular Genetics and Genomics 2008
Synergistic Efficacy of Concurrent Treatment with Cilostazol and Probucol on the Suppression of Reactive Oxygen Species and Inflammatory Markers in Cultured Human Coronary Artery Endothelial Cells
SY Park, JH Lee, HK Shin, CD Kim, WS Lee, BY Rhim, YW Shin, KW Hong
The Korean Journal of Physiology and Pharmacology 2008
Experimental models investigating the inflammatory basis of atherosclerosis
A Soliman, P Kee
Current Atherosclerosis Reports 2008
Monocyte-endothelial cell interactions in the development of atherosclerosis
J Mestas, K Ley
Trends in Cardiovascular Medicine 2008
Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice
BL Harry, JM Sanders, RE Feaver, M Lansey, TL Deem, A Zarbock, AC Bruce, AW Pryor, BD Gelfand, BR Blackman, MA Schwartz, K Ley
Arteriosclerosis, thrombosis, and vascular biology 2008
Epidemiology of cytokines: the Women On the Move through Activity and Nutrition (WOMAN) Study
E Wong, M Freiberg, R Tracy, L Kuller
American Journal of Epidemiology 2008
Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys
SE Walker, MR Adams, AA Franke, TC Register
Atherosclerosis 2008
Inflammation and Progressive Nephropathy in Type 1 Diabetes in the Diabetes Control and Complications Trial
J Lin, RJ Glynn, N Rifai, JE Manson, PM Ridker, DM Nathan, DA Schaumberg
Diabetes care 2008
Altered Gene Expression in Early Atherosclerosis Is Blocked by Low Level Apolipoprotein E
Y Ma, CC Malbon, DL Williams, FE Thorngate, G Pockley
PloS one 2008
Nuclear translocation of p65 NF-κB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction
M Zerfaoui, Y Suzuki, AS Naura, CP Hans, C Nichols, AH Boulares
Cellular Signalling 2008
P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6C hi Monocytes and a Major Determinant for Ly-6C hi Monocyte Recruitment to Sites of Atherosclerosis in Mice
G An, H Wang, R Tang, T Yago, JM McDaniel, S McGee, Y Huo, L Xia
Circulation 2008
Increased ADAM17 mRNA Expression and Activity Is Associated With Atherosclerosis Resistance in LDL-Receptor Deficient Mice
LM Holdt, J Thiery, JL Breslow, D Teupser
Arteriosclerosis, thrombosis, and vascular biology 2008
Magnetic Resonance Imaging of Endothelial Adhesion Molecules in Mouse Atherosclerosis Using Dual-Targeted Microparticles of Iron Oxide
MA McAteer, JE Schneider, ZA Ali, N Warrick, CA Bursill, C von zur Muhlen, DR Greaves, S Neubauer, KM Channon, RP Choudhury
Arteriosclerosis, thrombosis, and vascular biology 2008
Extravasation of leukocytes in comparison to tumor cells
C Strell, F Entschladen
Cell Communication and Signaling 2008
Chronic intermittent hypoxia induces atherosclerosis
V Savransky, A Nanayakkara, J Li, S Bevans, PL Smith, A Rodriguez, VY Polotsky
American journal of respiratory and critical care medicine 2007
Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis
L Zhang, K Peppel, P Sivashanmugam, ES Orman, L Brian, ST Exum, NJ Freedman
Arteriosclerosis, thrombosis, and vascular biology 2007
PPARalpha in atherosclerosis and inflammation
F Zandbergen, J Plutzky
Biochimica et Biophysica Acta 2007
SLEEP DISORDERED BREATHING AND METABOLIC EFFECTS: EVIDENCE FROM ANIMAL MODELS
J Jun, VY Polotsky
Sleep Medicine Clinics 2007
P2 receptors in atherosclerosis and postangioplasty restenosis
CI Seye, Q Kong, N Yu, FA Gonzalez, L Erb, GA Weisman
Purinergic Signalling 2007
P2 receptors in atherosclerosis and postangioplasty restenosis
CI Seye, Q Kong, N Yu, FA Gonzalez, L Erb, GA Weisman
Purinergic Signalling 2007
Molecular imaging of vascular cell adhesion molecule-1 expression in experimental atherosclerotic plaques with radiolabelled B2702-p
A Broisat, LM Riou, V Ardisson, D Boturyn, P Dumy, D Fagret, C Ghezzi
European Journal of Nuclear Medicine and Molecular Imaging 2007
Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells
CA Opitz, N Rimmerman, Y Zhang, LE Mead, MC Yoder, DA Ingram, JM Walker, J Rehman
FEBS Letters 2007
The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes
S Wolfrum, D Teupser, M Tan, KY Chen, JL Breslow
Proceedings of the National Academy of Sciences 2007
In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide
MA McAteer, NR Sibson, CZ Muhlen, JE Schneider, AS Lowe, N Warrick, KM Channon, DC Anthony, RP Choudhury
Nature Medicine 2007
Multiple risk markers for atherogenesis associated with chronic inflammation are detectable in patients with renal stones
KC Tsao, TL Wu, PY Chang, CF Sun, LL Wu, JT Wu
Journal of Clinical Laboratory Analysis 2007
Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate
J Wu, J Lin, Z He, B Ou, H Guo
Frontiers of Medicine in China 2007
Aggressive Very Low-Density Lipoprotein (VLDL) and LDL Lowering by Gene Transfer of the VLDL Receptor Combined with a Low-Fat Diet Regimen Induces Regression and Reduces Macrophage Content in Advanced Atherosclerotic Lesions in LDL Receptor-Deficient Mice
ED MacDougall, F Kramer, P Polinsky, S Barnhart, B Askari, F Johansson, R Varon, ME Rosenfeld, K Oka, L Chan, SM Schwartz, KE Bornfeldt
The American Journal of Pathology 2006
Keishibukuryogan (gui-zhi-fu-ling-wan), a Kampo formula, decreases disease activity and soluble vascular adhesion molecule-1 in patients with rheumatoid arthritis
K Nozaki, H Hikiami, H Goto, T Nakagawa, N Shibahara, Y Shimada
Evidence-based complementary and alternative medicine : eCAM 2006
Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis
J Jongstra-Bilen, M Haidari, SN Zhu, M Chen, D Guha, MI Cybulsky
Journal of Experimental Medicine 2006
The association of serum lipids and inflammatory biomarkers with renal function in men with type II diabetes mellitus
J Lin, FB Hu, EB Rimm, N Rifai, GC Curhan
Kidney International 2006
Peroxisome proliferator-activated receptor-α selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice
RA Srivastava, R Jahagirdar, S Azhar, S Sharma, CL Bisgaier
Molecular and Cellular Biochemistry 2006
Timp3 deficiency in Insulin receptor haploinsufficient mice promotes glucose intolerance and vascular inflammation via increased TNF-α
Massimo Federici, Marta L. Hribal, Rossella Menghini, Hiroko Kanno, Valentina Marchetti, Ottavia Porzio, Susan W. Sunnarborg, Stefano Rizza, Matteo Serino, Veronica Cunsolo, Davide Lauro, Alessandro Mauriello, David S. Smookler, Paolo Sbraccia, Giorgio Sesti, David C. Lee, Rama Khokha, Domenico Accili, Renato Lauro
Journal of Clinical Investigation 2005
Atherosclerosis: humoral and cellular factors of inflammation
AC Langheinrich, RM Bohle
Virchows Archiv 2005
VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin
T Ulyanova, LM Scott, GV Priestley, Y Jiang, B Nakamoto, PA Koni, T Papayannopoulou
Blood 2005
Molecular evidence for arterial repair in atherosclerosis
R Karra, S Vemullapalli, C Dong, EE Herderick, X Song, K Slosek, JR Nevins, M West, PJ Goldschmidt-Clermont, D Seo
Proceedings of the National Academy of Sciences 2005
Genomic rearrangements on VCAM1, SELE, APEG1 and AIF1 loci in atherosclerosis
DA Arvanitis, GA Flouris, DA Spandidos
Journal of Cellular and Molecular Medicine 2005
Immunoliposomes Directed Toward VCAM-1 Interact Specifically with Activated Endothelial Cells—A Potential Tool for Specific Drug Delivery
M Voinea, I Manduteanu, E Dragomir, M Capraru, M Simionescu
Pharmaceutical Research 2005
Cholesterol regulation of genes involved in sterol trafficking in human THP-1 macrophages
G Llaverias, D Lacasa, M Vázquez-Carrera, RM Sánchez, JC Laguna, M Alegret
Molecular and Cellular Biochemistry 2005
Inflammation as a mechanism and therapeutic target for in-stent restenosis
DE Drachman, DI Simon
Current Atherosclerosis Reports 2005
Thrombospondin‐1 up‐regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium
NV Narizhneva, OV Razorenova, EA Podrez, J Chen, UM Chandrasekharan, PE Dicorleto, EF Plow, EJ Topol, TV Byzova
The FASEB Journal 2005
Omega-3 Fatty Acids and the Regulation of Expression of Endothelial Pro-Atherogenic and Pro-Inflammatory Genes
RD Caterina, M Massaro
The Journal of Membrane Biology 2005
Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root
D Teupser, S Pavlides, M Tan, JC Gutierrez-Ramos, R Kolbeck, JL Breslow
Proceedings of the National Academy of Sciences 2004
Blasts from the past
PA Insel, S Kornfeld, PW Majerus, AR Marks, PA Marks, AS Relman, BF Scharschmidt, TP Stossel, AP Varki, SJ Weiss, JD Wilson
Journal of Clinical Investigation 2004
Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase
R Madonna, A Pandolfi, M Massaro, A Consoli, RD Caterina
Diabetologia 2004
Effects of omega-3 fatty acids on cytokines and adhesion molecules
RD Caterina, R Madonna, M Massaro
Current Atherosclerosis Reports 2004
Evolving Concepts in the Triad of Atherosclerosis, Inflammation and Thrombosis
R Corti, R Hutter, JJ Badimon, V Fuster
Journal of Thrombosis and Thrombolysis 2004
In vivo interrogation of the molecular display of atherosclerotic lesion surfaces
C Liu, G Bhattacharjee, W Boisvert, R Dilley, T Edgington
The American Journal of Pathology 2003
Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis
KS Moulton, K Vakili, D Zurakowski, M Soliman, C Butterfield, E Sylvin, KM Lo, S Gillies, K Javaherian, J Folkman
Proceedings of the National Academy of Sciences 2003
Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading
JX Rong, M Shapiro, E Trogan, EA Fisher
Proceedings of the National Academy of Sciences 2003
Two Hsp70 family members expressed in atherosclerotic lesions
Z Han, QA Truong, S Park, JL Breslow
Proceedings of the National Academy of Sciences 2003
Coronary artery disease, inflammation and the ghost of John Hunter
EL Fallen
Inflammopharmacology 2003
Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice
E Trogan, RP Choudhury, HM Dansky, JX Rong, JL Breslow, EA Fisher
Proceedings of the National Academy of Sciences 2002
A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation
S Massberg, K Brand, S Grüner, S Page, E Müller, I Müller, W Bergmeier, T Richter, M Lorenz, I Konrad, B Nieswandt, M Gawaz
Journal of Experimental Medicine 2002
Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
O Barreiro, M Yanez-Mo, JM Serrador, MC Montoya, M Vicente-Manzanares, R Tejedor, H Furthmayr, F Sanchez-Madrid
The Journal of Cell Biology 2002
Atherosclerotic lesions grow through recruitment and proliferation of circulating monocytes in a murine model.
Lessner SM, Prado HL, Waller EK, Galis ZS
The American Journal of Pathology 2002
Vascular cell adhesion molecule-1 is critical in atherosclerosis
Klaus Ley
Journal of Clinical Investigation 2001

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