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Citations to this article

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.
D F Kucik, … , J M Miller, E J Brown
D F Kucik, … , J M Miller, E J Brown
Published May 1, 1996
Citation Information: J Clin Invest. 1996;97(9):2139-2144. https://doi.org/10.1172/JCI118651.
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Research Article

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

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Abstract

Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed. The molecular details of the mechanism are unknown. To determine the effect of PMA activation on LFA-1 movement within the plasma membrane, we used the single particle tracking technique to measure the diffusion rate of LFA-1 molecules on EBV-transformed B cells before and after PMA activation. Diffusion of LFA-1 on unactivated cells was restricted compared to CR1 (CD35), another transmembrane protein of equivalent size. PMA caused a 10-fold increase in the diffusion rate of LFA-1 without any effect on CD35. The increased LFA-1 motion induced by PMA was random, not directed, indicating that it was due to a release of constraints rather than the application of forces. The diffusion rates of LFA-1 are consistent with cytoskeletal attachment before and free diffusion after PMA. Cytochalasin D led to an equivalent increase in mobility and, at low doses, stimulated adhesion, implying that the nonadhesive state of LFA-1 is actively maintained by the lymphocyte cytoskeleton.

Authors

D F Kucik, M L Dustin, J M Miller, E J Brown

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Microcirculation 2003
Disabling multiple integrins from the inside out
Y Shimizu
Journal of Clinical Investigation 2003
T-cell integrins: more than just sticking points
N Hogg, M Laschinger, K Giles, A McDowall
Journal of cell science 2003
Differential binding to dorsal and ventral cell surfaces of fibroblasts: effect on collagen phagocytosis
PD Arora, L Fan, J Sodek, A Kapus, CA McCulloch
Experimental Cell Research 2003
Integrin avidity regulation: are changes in affinity and conformation underemphasized?
CV Carman, TA Springer
Current Opinion in Cell Biology 2003
Vav1: a key signal transducer downstream of the TCR
VL Tybulewicz, L Ardouin, A Prisco, LF Reynolds
Immunological Reviews 2003
Concurrent signaling from Galphaq- and Galphai-coupled pathways is essential for agonist-induced alphavbeta3 activation on human platelets
BZ Paul, G Vilaire, SP Kunapuli, JS Bennett
Journal of Thrombosis and Haemostasis 2003
Avidity modulation activates adhesion under flow and requires cooperativity among adhesion receptors
N Ni, CG Kevil, DC Bullard, DF Kucik
Biophysical Journal 2003
Avidity Modulation Activates Adhesion under Flow and Requires Cooperativity among Adhesion Receptors
N Ni, CG Kevil, DC Bullard, DF Kucik
Biophysical Journal 2003
Bivalent Binding of IgA1 to FcαRI Suggests a Mechanism for Cytokine Activation of IgA Phagocytosis
AB Herr, CL White, C Milburn, C Wu, PJ Bjorkman
Journal of Molecular Biology 2003
Role for Plastin in Host Defense Distinguishes Integrin Signaling from Cell Adhesion and Spreading
H Chen, A Mocsai, H Zhang, RX Ding, JH Morisaki, M White, JM Rothfork, P Heiser, E Colucci-Guyon, CA Lowell, HD Gresham, PM Allen, EJ Brown
Immunity 2003
LAD-III, a novel group of leukocyte integrin activation deficiencies
Ronen Alon, Amos Etzioni
Trends in Immunology 2003
Signal transduction events regulating integrin function and T cell migration: new functions and complexity
Jonathan T Pribila, Yoji Shimizu
Immunologic Research 2003
Detection of Integrin α IIb β 3 Clustering in Living Cells
C Buensuceso, M Virgilio, SJ Shattil
The Journal of biological chemistry 2003
Fcγ-receptors Induce Mac-1 (CD11b/CD18) Mobilization and Accumulation in the Phagocytic Cup for Optimal Phagocytosis
J Jongstra-Bilen, R Harrison, S Grinstein
The Journal of biological chemistry 2003
The Critical Cytoplasmic Regions of the αL/β2 Integrin in Rap1-induced Adhesion and Migration
Y Tohyama, K Katagiri, R Pardi, C Lu, TA Springer, T Kinashi
Molecular biology of the cell 2003
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
K Katagiri, A Maeda, M Shimonaka, T Kinashi
Nature Immunology 2003
The Rap GTPases Regulate Integrin-mediated Adhesion, Cell Spreading, Actin Polymerization, and Pyk2 Tyrosine Phosphorylation in B Lymphocytes
SJ McLeod, AJ Shum, RL Lee, F Takei, MR Gold
The Journal of biological chemistry 2003
RhoA and ROCK Promote Migration by Limiting Membrane Protrusions
RA Worthylake, K Burridge
The Journal of biological chemistry 2003
De Novo Expression of the Integrin α 5 β 1 Regulates α v β 3 -mediated Adhesion and Migration on Fibrinogen
DP Ly, KM Zazzali, SA Corbett
The Journal of biological chemistry 2003
Isolation and Isotope Labeling of Cysteine- and Methionine-containing Tryptic Peptides: Application to the Study of Cell Surface Proteolysis
M Shen, L Guo, A Wallace, J Fitzner, J Eisenman, E Jacobson, RS Johnson
Molecular & cellular proteomics : MCP 2003
Lymphocyte Function-associated Antigen-1-mediated T Cell Adhesion Is Impaired by Low Molecular Weight Phosphotyrosine Phosphatase-dependent Inhibition of FAK Activity
E Giannoni, P Chiarugi, G Cozzi, L Magnelli, ML Taddei, T Fiaschi, F Buricchi, G Raugei, G Ramponi
The Journal of biological chemistry 2003
Coxiella burnetii Avoids Macrophage Phagocytosis by Interfering with Spatial Distribution of Complement Receptor 3
C Capo, A Moynault, Y Collette, D Olive, EJ Brown, D Raoult, JL Mege
Journal of immunology (Baltimore, Md. : 1950) 2003
Mass Spectrometric Based Mapping of the Disulfide Bonding Patterns of Integrin α Chains
OV Krokhin, K Cheng, SL Sousa, W Ens, KG Standing, JA Wilkins
Biochemistry 2003
Requirement for RhoA kinase activation in leukocyte de-adhesion
L Liu, BR Schwartz, N Lin, RK Winn, JM Harlan
Journal of immunology (Baltimore, Md. : 1950) 2002
Coming to grips with integrin binding to ligands
MA Arnaout, SL Goodman, JP Xiong
Current Opinion in Cell Biology 2002
The immunological synapse: integrins take the stage
TN Sims, ML Dustin
Immunological Reviews 2002
Mechanisms contributing to the activity of integrins on leukocytes
N Hogg, R Henderson, B Leitinger, A McDowall, J Porter, P Stanley
Immunological Reviews 2002
Genetic analysis of integrin activation in T lymphocytes
SA Kellermann, CL Dell, SW Hunt, Y Shimizu
Immunological Reviews 2002
Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue
J Delon, S Stoll, RN Germain
Immunological Reviews 2002
A Modified Micropipette Aspiration Technique and Its Application to Tether Formation From Human Neutrophils
JY Shao, J Xu
Journal of Biomechanical Engineering 2002
The synapse assembly model
SJ Lee, Y Hori, JT Groves, ML Dustin, AK Chakraborty
Trends in Immunology 2002
From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts
R Alon, S Feigelson
Seminars in Immunology 2002
Vav1 Controls Integrin Clustering and MHC/Peptide-Specific Cell Adhesion to Antigen-Presenting Cells
C Krawczyk, A Oliveira-dos-Santos, T Sasaki, E Griffiths, PS Ohashi, S Snapper, F Alt, JM Penninger
Immunity 2002
Dynamic Regulation of LFA-1 Activation and Neutrophil Arrest on Intercellular Adhesion Molecule 1 (ICAM-1) in Shear Flow
AF Lum, CE Green, GR Lee, DE Staunton, SI Simon
The Journal of biological chemistry 2002
Lymphocyte Activation and Immune Regulation IX
S Gupta, E Butcher, W Paul
Lymphocyte Activation and Immune Regulation IX 2002
Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo
DB McGavern, U Christen, MB Oldstone
Nature Immunology 2002
Age-Dependent Defects in TCR-Triggered Cytoskeletal Rearrangement in CD4 + T Cells
GG Garcia, RA Miller
Journal of immunology (Baltimore, Md. : 1950) 2002
The involvement of lipid rafts in the regulation of integrin function
B Leitinger, N Hogg
Journal of cell science 2002
Rearrangement of Integrins in Avidity Regulation by Leukocytes
DF Kucik
Immunologic Research 2002
Inhibition of tyrosine kinases blocks adhesion-induced T-cell coactivation without interfering with T-cell adhesion to endothelial cell-surface ligands
Dawn M Nowlin, Pina M Cardarelli, Lynn Young, Jason Mah, Katherine A Felts, Marian Mastrangelo, Ronald R Cobb
Inflammation 2002
Evidence for the Involvement of Phosphatidylinositol 3-Kinase in fMLP-Stimulated Neutrophil Adhesion to ICAM-1-Transfected Cells
F Pellegatta, A Radaelli, S Heltai, L Yan, SL Chierchia, F Folli
Journal of Cardiovascular Pharmacology 2001
HHV8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype
S Tanaka, H Katano, K Tsukamoto, M Jin, S Oikawa, H Nishihara, H Sawa, K Sawada, M Shimizu, T Sata, Y Fujioka, K Nagashima
Pathology International 2001
IDENTIFICATION OFSELFTHROUGHTWO-DIMENSIONALCHEMISTRY ANDSYNAPSES
ML Dustin, SK Bromley, MM Davis, C Zhu
Annual Review of Cell and Developmental Biology 2001
THEIMMUNOLOGICALSYNAPSE
SK Bromley, WR Burack, KG Johnson, K Somersalo, TN Sims, C Sumen, MM Davis, AS Shaw, PM Allen, ML Dustin
Annual Review of Immunology 2001
Leukocyte transendothelial migration: orchestrating the underlying molecular machinery
RA Worthylake, K Burridge
Current Opinion in Cell Biology 2001
The immune dysregulatory compound mercuric chloride induces integrin-mediated T-lymphocyte adhesion
A Roos, M Neeft, L Engelen, EJ Schilder-Tol, U Kunzendorf, JJ Weening, J Aten
Immunology 2001
Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains
R Li, CR Babu, JD Lear, AJ Wand, JS Bennett, WF DeGrado
Proceedings of the National Academy of Sciences 2001
Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether
O Dwir, GS Kansas, R Alon
The Journal of Cell Biology 2001
Imaging T-cell antigen recognition and comparing immunological and neuronal synapses
E Donnadieu, P Revy, A Trautmann
Immunology 2001
RhoA is required for monocyte tail retraction during transendothelial migration
RA Worthylake, S Lemoine, JM Watson, K Burridge
The Journal of Cell Biology 2001
A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor
ML Woods, WJ Kivens, MA Adelsman, Y Qiu, A August, Y Shimizu
The EMBO Journal 2001
Adaptor ADAP (Adhesion- and Degranulation-Promoting Adaptor Protein) Regulates β1 Integrin Clustering on Mast Cells
L Geng, C Rudd
Biochemical and Biophysical Research Communications 2001
A Novel Anti-CD 18 mAb Recognizes an Activation-Related Epitope and Induces a High-Affinity Conformation in Leukocyte Integrins
K Drbal, P Angelisová, J Černý, I Hilgert, V Hořejší
Immunobiology 2001
A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by beta1 and beta2 integrins
ES Harris, AO Shigeoka, W Li, RH Adams, SM Prescott, TM McIntyre, GA Zimmerman, DE Lorant
Blood 2001
The immunological synapse and CD28-CD80 interactions
SK Bromley, A Iaboni, SJ Davis, A Whitty, JM Green, AS Shaw, A Weiss, ML Dustin
Nature Immunology 2001
In Vivo Interaction between Dynamitin and MacMARCKS Detected by the Fluorescent Resonance Energy Transfer Method
T Jin, L Yue, J Li
The Journal of biological chemistry 2001
L-plastin Peptide Activation of α v β 3 -mediated Adhesion Requires Integrin Conformational Change and Actin Filament Disassembly
J Wang, H Chen, EJ Brown
The Journal of biological chemistry 2001
Rho and Rho-associated Kinase Modulate the Tyrosine Kinase PYK2 in T-cells through Regulation of the Activity of the Integrin LFA-1
JL Rodrı́guez-Fernández, L Sánchez-Martı́n, M Rey, M Vicente-Manzanares, S Narumiya, J Teixidó, F Sánchez-Madrid, C Cabañas
The Journal of biological chemistry 2001
Activation-enhanced α IIb β 3 -Integrin–Cytoskeleton Interactions Outside of Focal Contacts Require the α-Subunit
DF Kucik, TE O'Toole, A Zheleznyak, DK Busettini, EJ Brown, JS Brugge
Molecular biology of the cell 2001
Activation of α v β3-Vitronectin Binding Is a Multistage Process in which Increases in Bond Strength Are Dependent on Y747 and Y759 in the Cytoplasmic Domain of β3
D Boettiger, F Huber, L Lynch, S Blystone, JS Brugge
Molecular biology of the cell 2001
Physiology of Inflammation
K Ley
2001
A Dominant Jurkat T Cell Mutation That Inhibits LFA-1-Mediated Cell Adhesion Is Associated with Increased Cell Growth
LK Cherry, KS Weber, LB Klickstein
Journal of immunology (Baltimore, Md. : 1950) 2001
CD18 Activation Epitopes Induced by Leukocyte Activation
CR Beals, AC Edwards, RJ Gottschalk, TW Kuijpers, DE Staunton
Journal of immunology (Baltimore, Md. : 1950) 2001
Platelet/polymorphonuclear leukocyte adhesion: a new role for SRC kinases in Mac-1 adhesive function triggered by P-selectin
P Piccardoni, R Sideri, S Manarini, A Piccoli, N Martelli, G de Gaetano, C Cerletti, V Evangelista
Blood 2001
Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-70
MM Morgan, CM Labno, GA Seventer, MF Denny, DB Straus, JK Burkhardt
Journal of immunology (Baltimore, Md. : 1950) 2001
Cellular Activation of Leukocyte Function-Associated Antigen-1 and Its Affinity Are Regulated at the I Domain Allosteric Site
ML Lupher, EA Harris, CR Beals, LM Sui, RC Liddington, DE Staunton
Journal of immunology (Baltimore, Md. : 1950) 2001
Subversion of integrins by enteropathogenic Yersinia
RR Isberg, P Barnes
Journal of cell science 2001
Role of adhesion molecules in activation signaling in T lymphocytes
M L Dustin
Journal of Clinical Immunology 2001
Expression of MacMARCKS Restores Cell Adhesion to ICAM-1-Coated Surface
L Yue, Z Bao, J Li
Cell Communication and Adhesion 2000
Avidity regulation of integrins: the driving force in leukocyte adhesion
Y Kooyk, CG Figdor
Current Opinion in Cell Biology 2000
Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition
PA der Merwe, SJ Davis, AS Shaw, ML Dustin
Seminars in Immunology 2000
Signaling Takes Shape in the Immune System
ML Dustin, AC Chan
Cell 2000
Bi-directional signal transduction by integrin receptors
MG Coppolino, S Dedhar
The International Journal of Biochemistry & Cell Biology 2000
The Leukocyte Integrins
ES Harris, TM McIntyre, SM Prescott, GA Zimmerman
The Journal of biological chemistry 2000
Integrin-Mediated Drug Resistance in Multiple Myeloma
JS Damiano, WS Dalton
Leukemia & Lymphoma 2000
R-Ras Contains a Proline-rich Site That Binds to SH3 Domains and Is Required for Integrin Activation by R-Ras
B Wang, JX Zou, B Ek-Rylander, E Ruoslahti
The Journal of biological chemistry 2000
Evaluation of Prototype Transmembrane 4 Superfamily Protein Complexes and Their Relation to Lipid Rafts
C Claas, CS Stipp, ME Hemler
The Journal of biological chemistry 2000
Macrophage-enriched Myristoylated Alanine-rich C Kinase Substrate and Its Phosphorylation Is Required for the Phorbol Ester-stimulated Diffusion of β 2 Integrin Molecules
X Zhou, J Li
The Journal of biological chemistry 2000
Protein Kinase C-regulated Dynamitin-Macrophage-enriched Myristoylated Alanine-Rice C Kinase Substrate Interaction Is Involved in Macrophage Cell Spreading
L Yue, S Lu, J Garces, T Jin, J Li
The Journal of biological chemistry 2000
Distinct Mechanisms of α 5 β 1 Integrin Activation by Ha-Ras and R-Ras
T Kinashi, K Katagiri, S Watanabe, B Vanhaesebroeck, J Downward, K Takatsu
The Journal of biological chemistry 2000
The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
ML Dustin, JA Cooper
Nature Immunology 2000
Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling
DA Calderwood, SJ Shattil, MH Ginsberg
The Journal of biological chemistry 2000
Dynamic Regulation of Activated Leukocyte Cell Adhesion Molecule–mediated Homotypic Cell Adhesion through the Actin Cytoskeleton
JM Nelissen, IM Peters, BG de Grooth, Y van Kooyk, CG Figdor, M Schwartz
Molecular biology of the cell 2000
Pulmonary Immunotoxicology
MD Cohen, JT Zelikoff, RB Schlesinger
2000
The parting of the endothelium: miracle, or simply a junctional affair?
C Johnson-Leger, M Aurrand-Lions, BA Imhof
Journal of cell science 2000
α 4 β 1 Integrin/VCAM-1 Interaction Activates α L β 2 Integrin-Mediated Adhesion to ICAM-1 in Human T Cells
JR Chan, SJ Hyduk, MI Cybulsky
Journal of immunology (Baltimore, Md. : 1950) 2000
Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule–1
ER Hentzen, S Neelamegham, GS Kansas, JA Benanti, LV McIntire, CW Smith, SI Simon
Blood 2000
The LFA-1 Integrin Supports Rolling Adhesions on ICAM-1 Under Physiological Shear Flow in a Permissive Cellular Environment
A Sigal, DA Bleijs, V Grabovsky, SJ van Vliet, O Dwir, CG Figdor, Y van Kooyk, R Alon
Journal of immunology (Baltimore, Md. : 1950) 2000
Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils
SI Anderson, NA Hotchin, GB Nash
Journal of cell science 2000
Low-affinity LFA-1/ICAM-3 interactions augment LFA-1/ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1
DA Bleijs, ME Binnerts, SJ van Vliet, CG Figdor, Y van Kooyk
Journal of cell science 2000
Soluble VCAM-1 binding to α4 integrins is cell-type specific and activation dependent and is disrupted during apoptosis in T cells
DM Rose, PM Cardarelli, RR Cobb, MH Ginsberg
Blood 2000
Nerve growth factor stimulates coupling of beta1 integrin to distinct transport mechanisms in the filopodia of growth cones
PW Grabham, M Foley, A Umeojiako, DJ Goldberg
Journal of cell science 2000
Phosphorylated form of MacMARCKS is essential to LFA-1-dependent cell-cell adhesion of U937 monocytic cells
L Yue, Z Bao, J Li
Journal of Cellular Physiology 1999
The cytoskeletal association of CD11/CD18 leukocyte integrins in phorbol ester-activated cells correlates with CD18 phosphorylation
L Valmu, S Fagerholm, H Suila, CG Gahmberg
European Journal of Immunology 1999
Regulation of integrin function by T cell activation
T Zeil, WJ Kivens, SA Kellermann, Y Shimizu
Immunologic Research 1999
Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization
MS Chen, KS Tung, SA Coonrod, Y Takahashi, D Bigler, A Chang, Y Yamashita, PW Kincade, JC Herr, JM White
Proceedings of the National Academy of Sciences 1999
Function of the cytoskeleton in human neutrophils and methods for evaluation
M Torres, TD Coates
Journal of Immunological Methods 1999
Advances in Cellular and Molecular Biology of Membranes and Organelles
MA Horwitz, DL Clemens
Advances in Cellular and Molecular Biology of Membranes and Organelles 1999
PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells
K Cichowski, M J Orsini, L F Brass
Biochimica et Biophysica Acta 1999
Primary Megakaryocytes Reveal a Role for Transcription Factor Nf-E2 in Integrin αiibβ3 Signaling
M Shiraga, A Ritchie, S Aidoudi, V Baron, D Wilcox, G White, B Ybarrondo, G Murphy, A Leavitt, S Shattil
The Journal of Cell Biology 1999
Evidence that Distinct States of the Integrin α6β1 Interact with Laminin and an ADAM
MS Chen, EA Almeida, AP Huovila, Y Takahashi, LM Shaw, AM Mercurio, JM White
The Journal of Cell Biology 1999
Enhancement of Endothelial Cell Migration and in Vitro Tube Formation by Tap20, a Novel β5 Integrin–Modulating, Pkcθ-Dependent Protein
S Tang, Y Gao, JA Ware
The Journal of Cell Biology 1999
The Platelet Cytoskeleton Regulates the Affinity of the Integrin α IIb β 3 for Fibrinogen
JS Bennett, S Zigmond, G Vilaire, ME Cunningham, B Bednar
The Journal of biological chemistry 1999
Immune Complex-induced Integrin Activation and L-plastin Phosphorylation Require Protein Kinase A
J Wang, EJ Brown
The Journal of biological chemistry 1999
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation
DA Calderwood, R Zent, R Grant, DJ Rees, RO Hynes, MH Ginsberg
The Journal of biological chemistry 1999
The Actin Cytoskeleton Regulates LFA-1 Ligand Binding through Avidity Rather than Affinity Changes
Y Kooyk, SJ van Vliet, CG Figdor
The Journal of biological chemistry 1999
Mechanisms and Consequences of Affinity Modulation of Integrin α V β 3 Detected with a Novel Patch-engineered Monovalent Ligand
N Pampori, T Hato, DG Stupack, S Aidoudi, DA Cheresh, GR Nemerow, SJ Shattil
The Journal of biological chemistry 1999
Specific Activation of Leukocyte β2 Integrins Lymphocyte Function–associated Antigen-1 and Mac-1 by Chemokines Mediated by Distinct Pathways via the α Subunit Cytoplasmic Domains
KS Weber, LB Klickstein, C Weber, CH Heldin
Molecular biology of the cell 1999
Disruption of filamentous actin inhibits human macrophage fusion
KR DeFIFE, CR Jenney, E Colton, JM Anderson
The FASEB Journal 1999
Regulation of integrin function by T cell activation: Points of Convergence and Divergence
T Zeil, WJ Kivens, SA Kellermann, Y Shimizu
Immunologic Research 1999
Integrin associated proteins
ME Hemler
Current Opinion in Cell Biology 1998
Integrin affinity modulation
PE Hughes, M Pfaff
Trends in Cell Biology 1998
β1 integrin cytoplasmic domain regulates the constitutive conformation detected by MAb 15/7, but not the ligand-induced conformation
D Crommie, ME Hemler
Journal of Cellular Biochemistry 1998
Three dimensional single-particle tracking with nanometer resolution
IM Peters, BG de Grooth, JM Schins, CG Figdor, J Greve
Review of Scientific Instruments 1998
Are changes in integrin affinity and conformation overemphasized?
G Bazzoni, ME Hemler
Trends in Biochemical Sciences 1998
Adhesion and Signaling Mediated by the Cytoplasmic Tails of Leucocyte Integrins
YV Kooyk, M Lub, CG Figdor
Cell Communication and Adhesion 1998
Making a Little Affinity Go a Long Way: A Topological View of LFA-1 Regulation
ML Dustin
Cell Communication and Adhesion 1998
Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3
T Hato, N Pampori, SJ Shattil
The Journal of Cell Biology 1998
Interactions of the cytoplasmic domain of P-selectin with clathrin-coated pits enhance leukocyte adhesion under flow
H Setiadi, G Sedgewick, SL Erlandsen, RP McEver
The Journal of Cell Biology 1998
Cytoskeletal interactions with the leukocyte integrin beta2 cytoplasmic tail. Activation-dependent regulation of associations with talin and alpha-actinin
R Sampath, PJ Gallagher, FM Pavalko
The Journal of biological chemistry 1998
A role for the actin-bundling protein L-plastin in the regulation of leukocyte integrin function
SL Jones, J Wang, CW Turck, EJ Brown
Proceedings of the National Academy of Sciences 1998
LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain
MP Stewart, A McDowall, N Hogg
The Journal of Cell Biology 1998
Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin
TV Byzova, EF Plow
The Journal of Cell Biology 1998
Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils
SL Jones, UG Knaus, GM Bokoch, EJ Brown
The Journal of biological chemistry 1998
LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca 2+ -dependent Protease, Calpain
MP Stewart, A McDowall, N Hogg
The Journal of Cell Biology 1998
Activation of α V β 3 on Vascular Cells Controls Recognition of Prothrombin
TV Byzova, EF Plow
The Journal of Cell Biology 1998
Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin α IIb β 3
T Hato, N Pampori, SJ Shattil
The Journal of Cell Biology 1998
Regulation of Integrin-Mediated Adhesion by Muscarinic Acetylcholine Receptors and Protein Kinase C in Small Cell Lung Carcinoma
RL Quigley, SH Shafer, CL Williams
Chest 1998
Regulation of αIIbβ3 Function in Human B Lymphocytes
W Qi, E Loh, G Vilaire, JS Bennett
The Journal of biological chemistry 1998
Cytoskeletal Interactions with the Leukocyte Integrin β2 Cytoplasmic Tail: ACTIVATION-DEPENDENT REGULATION OF ASSOCIATIONS WITH TALIN AND α-ACTININ
R Sampath, PJ Gallagher, FM Pavalko
The Journal of biological chemistry 1998
The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity
JG van de Winkel, PM Hogarth
1998
Integrin Signaling: The Platelet Paradigm
SJ Shattil, H Kashiwagi, N Pampori
Blood 1998
RhoA and the Function of Platelet Integrin αIIbβ3
L Leng, H Kashiwagi, XD Ren, SJ Shattil
Blood 1998
Constitutive Chemokine Production Results in Activation of Leukocyte Function-Associated Antigen-1 on Adult T-Cell Leukemia Cells
Y Tanaka, S Mine, CG Figdor, A Wake, H Hirano, J Tsukada, M Aso, K Fujii, K Saito, Y van Kooyk, S Eto
Blood 1998
Integrin α chain cytoplasmic tails regulate “antibody-redirected” cell adhesion, independently of ligand binding
JB Weitzman, C Pujades, ME Hemler
European Journal of Immunology 1997
Emerging paradigms of integrin ligand binding and activation
T Sugimori, DL Griffith, MA Arnaout
Kidney International 1997
Leukocyte Adhesion. Structure and Function of Human Leukocyte beta2-Integrins and their Cellular Ligands
CG Gahmberg, M Tolvanen, P Kotovuori
European Journal of Biochemistry 1997
Role of ligands in the activation of LFA-1
CD Buckley, ED Ferguson, AJ Littler, D Bossy, DL Simmons
European Journal of Immunology 1997
Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding
RL Yauch, DP Felsenfeld, SK Kraeft, LB Chen, MP Sheetz, ME Hemler
Journal of Experimental Medicine 1997
The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow
R Knorr, ML Dustin
Journal of Experimental Medicine 1997
Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1
M Lub, Y Kooyk, SJ van Vliet, CG Figdor
Molecular biology of the cell 1997
Classification of `activation' antibodies against integrin β1 chain
J Tsuchida, S Ueki, Y Saito, J Takagi
FEBS Letters 1997
The Lymphocyte Function-associated Antigen 1 I Domain Is a Transient Binding Module for Intercellular Adhesion Molecule (ICAM)-1 and ICAM-3 in Hydrodynamic Flow
R Knorr, ML Dustin
Journal of Experimental Medicine 1997
Mutational Evidence for Control of Cell Adhesion Through Integrin Diffusion/Clustering, Independent of Ligand Binding
RL Yauch, DP Felsenfeld, SK Kraeft, LB Chen, MP Sheetz, ME Hemler
Journal of Experimental Medicine 1997
Muscle β1D Integrin Reinforces the Cytoskeleton–Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing
AM Belkin, SF Retta, OY Pletjushkina, F Balzac, L Silengo, R Fassler, VE Koteliansky, K Burridge, G Tarone
The Journal of Cell Biology 1997
Requirement of Integrin β 3 Tyrosine 747 for β 3 Tyrosine Phosphorylation and Regulation of α v β 3 Avidity
SD Blystone, MP Williams, SE Slater, EJ Brown
The Journal of biological chemistry 1997
Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity
ML Dustin, DE Golan, DM Zhu, JM Miller, W Meier, EA Davies, PA van der Merwe
The Journal of biological chemistry 1997
Where the outside meets the inside: integrins as activators and targets of signal transduction cascades
E Brown, N Hogg
Immunology Letters 1996
Genetic Engineering
P Little
Genetic Engineering 1981

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