Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed. The molecular details of the mechanism are unknown. To determine the effect of PMA activation on LFA-1 movement within the plasma membrane, we used the single particle tracking technique to measure the diffusion rate of LFA-1 molecules on EBV-transformed B cells before and after PMA activation. Diffusion of LFA-1 on unactivated cells was restricted compared to CR1 (CD35), another transmembrane protein of equivalent size. PMA caused a 10-fold increase in the diffusion rate of LFA-1 without any effect on CD35. The increased LFA-1 motion induced by PMA was random, not directed, indicating that it was due to a release of constraints rather than the application of forces. The diffusion rates of LFA-1 are consistent with cytoskeletal attachment before and free diffusion after PMA. Cytochalasin D led to an equivalent increase in mobility and, at low doses, stimulated adhesion, implying that the nonadhesive state of LFA-1 is actively maintained by the lymphocyte cytoskeleton.
D F Kucik, M L Dustin, J M Miller, E J Brown
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Immunity | 2003 |
LAD-III, a novel group of leukocyte integrin activation deficiencies
Ronen Alon, Amos Etzioni |
Trends in Immunology | 2003 |
Signal transduction events regulating integrin function and T cell migration: new functions and complexity
Jonathan T Pribila, Yoji Shimizu |
Immunologic Research | 2003 |
Detection of Integrin α IIb β 3 Clustering in Living Cells
C Buensuceso, M Virgilio, SJ Shattil |
The Journal of biological chemistry | 2003 |
Fcγ-receptors Induce Mac-1 (CD11b/CD18) Mobilization and Accumulation in the Phagocytic Cup for Optimal Phagocytosis
J Jongstra-Bilen, R Harrison, S Grinstein |
The Journal of biological chemistry | 2003 |
The Critical Cytoplasmic Regions of the αL/β2 Integrin in Rap1-induced Adhesion and Migration
Y Tohyama, K Katagiri, R Pardi, C Lu, TA Springer, T Kinashi |
Molecular biology of the cell | 2003 |
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
K Katagiri, A Maeda, M Shimonaka, T Kinashi |
Nature Immunology | 2003 |
The Rap GTPases Regulate Integrin-mediated Adhesion, Cell Spreading, Actin Polymerization, and Pyk2 Tyrosine Phosphorylation in B Lymphocytes
SJ McLeod, AJ Shum, RL Lee, F Takei, MR Gold |
The Journal of biological chemistry | 2003 |
RhoA and ROCK Promote Migration by Limiting Membrane Protrusions
RA Worthylake, K Burridge |
The Journal of biological chemistry | 2003 |
De Novo Expression of the Integrin α 5 β 1 Regulates α v β 3 -mediated Adhesion and Migration on Fibrinogen
DP Ly, KM Zazzali, SA Corbett |
The Journal of biological chemistry | 2003 |
Isolation and Isotope Labeling of Cysteine- and Methionine-containing Tryptic Peptides: Application to the Study of Cell Surface Proteolysis
M Shen, L Guo, A Wallace, J Fitzner, J Eisenman, E Jacobson, RS Johnson |
Molecular & cellular proteomics : MCP | 2003 |
Lymphocyte Function-associated Antigen-1-mediated T Cell Adhesion Is Impaired by Low Molecular Weight Phosphotyrosine Phosphatase-dependent Inhibition of FAK Activity
E Giannoni, P Chiarugi, G Cozzi, L Magnelli, ML Taddei, T Fiaschi, F Buricchi, G Raugei, G Ramponi |
The Journal of biological chemistry | 2003 |
Coxiella burnetii Avoids Macrophage Phagocytosis by Interfering with Spatial Distribution of Complement Receptor 3
C Capo, A Moynault, Y Collette, D Olive, EJ Brown, D Raoult, JL Mege |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Mass Spectrometric Based Mapping of the Disulfide Bonding Patterns of Integrin α Chains
OV Krokhin, K Cheng, SL Sousa, W Ens, KG Standing, JA Wilkins |
Biochemistry | 2003 |
Requirement for RhoA kinase activation in leukocyte de-adhesion
L Liu, BR Schwartz, N Lin, RK Winn, JM Harlan |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
Coming to grips with integrin binding to ligands
MA Arnaout, SL Goodman, JP Xiong |
Current Opinion in Cell Biology | 2002 |
The immunological synapse: integrins take the stage
TN Sims, ML Dustin |
Immunological Reviews | 2002 |
Mechanisms contributing to the activity of integrins on leukocytes
N Hogg, R Henderson, B Leitinger, A McDowall, J Porter, P Stanley |
Immunological Reviews | 2002 |
Genetic analysis of integrin activation in T lymphocytes
SA Kellermann, CL Dell, SW Hunt, Y Shimizu |
Immunological Reviews | 2002 |
Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue
J Delon, S Stoll, RN Germain |
Immunological Reviews | 2002 |
A Modified Micropipette Aspiration Technique and Its Application to Tether Formation From Human Neutrophils
JY Shao, J Xu |
Journal of Biomechanical Engineering | 2002 |
The synapse assembly model
SJ Lee, Y Hori, JT Groves, ML Dustin, AK Chakraborty |
Trends in Immunology | 2002 |
From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts
R Alon, S Feigelson |
Seminars in Immunology | 2002 |
Vav1 Controls Integrin Clustering and MHC/Peptide-Specific Cell Adhesion to Antigen-Presenting Cells
C Krawczyk, A Oliveira-dos-Santos, T Sasaki, E Griffiths, PS Ohashi, S Snapper, F Alt, JM Penninger |
Immunity | 2002 |
Dynamic Regulation of LFA-1 Activation and Neutrophil Arrest on Intercellular Adhesion Molecule 1 (ICAM-1) in Shear Flow
AF Lum, CE Green, GR Lee, DE Staunton, SI Simon |
The Journal of biological chemistry | 2002 |
Lymphocyte Activation and Immune Regulation IX
S Gupta, E Butcher, W Paul |
Lymphocyte Activation and Immune Regulation IX | 2002 |
Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo
DB McGavern, U Christen, MB Oldstone |
Nature Immunology | 2002 |
Age-Dependent Defects in TCR-Triggered Cytoskeletal Rearrangement in CD4 + T Cells
GG Garcia, RA Miller |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
The involvement of lipid rafts in the regulation of integrin function
B Leitinger, N Hogg |
Journal of cell science | 2002 |
Rearrangement of Integrins in Avidity Regulation by Leukocytes
DF Kucik |
Immunologic Research | 2002 |
Inhibition of tyrosine kinases blocks adhesion-induced T-cell coactivation without interfering with T-cell adhesion to endothelial cell-surface ligands
Dawn M Nowlin, Pina M Cardarelli, Lynn Young, Jason Mah, Katherine A Felts, Marian Mastrangelo, Ronald R Cobb |
Inflammation | 2002 |
Evidence for the Involvement of Phosphatidylinositol 3-Kinase in fMLP-Stimulated Neutrophil Adhesion to ICAM-1-Transfected Cells
F Pellegatta, A Radaelli, S Heltai, L Yan, SL Chierchia, F Folli |
Journal of Cardiovascular Pharmacology | 2001 |
HHV8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype
S Tanaka, H Katano, K Tsukamoto, M Jin, S Oikawa, H Nishihara, H Sawa, K Sawada, M Shimizu, T Sata, Y Fujioka, K Nagashima |
Pathology International | 2001 |
IDENTIFICATION OFSELFTHROUGHTWO-DIMENSIONALCHEMISTRY ANDSYNAPSES
ML Dustin, SK Bromley, MM Davis, C Zhu |
Annual Review of Cell and Developmental Biology | 2001 |
THEIMMUNOLOGICALSYNAPSE
SK Bromley, WR Burack, KG Johnson, K Somersalo, TN Sims, C Sumen, MM Davis, AS Shaw, PM Allen, ML Dustin |
Annual Review of Immunology | 2001 |
Leukocyte transendothelial migration: orchestrating the underlying molecular machinery
RA Worthylake, K Burridge |
Current Opinion in Cell Biology | 2001 |
The immune dysregulatory compound mercuric chloride induces integrin-mediated T-lymphocyte adhesion
A Roos, M Neeft, L Engelen, EJ Schilder-Tol, U Kunzendorf, JJ Weening, J Aten |
Immunology | 2001 |
Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains
R Li, CR Babu, JD Lear, AJ Wand, JS Bennett, WF DeGrado |
Proceedings of the National Academy of Sciences | 2001 |
Cytoplasmic anchorage of L-selectin controls leukocyte capture and rolling by increasing the mechanical stability of the selectin tether
O Dwir, GS Kansas, R Alon |
The Journal of Cell Biology | 2001 |
Imaging T-cell antigen recognition and comparing immunological and neuronal synapses
E Donnadieu, P Revy, A Trautmann |
Immunology | 2001 |
RhoA is required for monocyte tail retraction during transendothelial migration
RA Worthylake, S Lemoine, JM Watson, K Burridge |
The Journal of Cell Biology | 2001 |
A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor
ML Woods, WJ Kivens, MA Adelsman, Y Qiu, A August, Y Shimizu |
The EMBO Journal | 2001 |
Adaptor ADAP (Adhesion- and Degranulation-Promoting Adaptor Protein) Regulates β1 Integrin Clustering on Mast Cells
L Geng, C Rudd |
Biochemical and Biophysical Research Communications | 2001 |
A Novel Anti-CD 18 mAb Recognizes an Activation-Related Epitope and Induces a High-Affinity Conformation in Leukocyte Integrins
K Drbal, P Angelisová, J Černý, I Hilgert, V Hořejší |
Immunobiology | 2001 |
A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by beta1 and beta2 integrins
ES Harris, AO Shigeoka, W Li, RH Adams, SM Prescott, TM McIntyre, GA Zimmerman, DE Lorant |
Blood | 2001 |
The immunological synapse and CD28-CD80 interactions
SK Bromley, A Iaboni, SJ Davis, A Whitty, JM Green, AS Shaw, A Weiss, ML Dustin |
Nature Immunology | 2001 |
In Vivo Interaction between Dynamitin and MacMARCKS Detected by the Fluorescent Resonance Energy Transfer Method
T Jin, L Yue, J Li |
The Journal of biological chemistry | 2001 |
L-plastin Peptide Activation of α v β 3 -mediated Adhesion Requires Integrin Conformational Change and Actin Filament Disassembly
J Wang, H Chen, EJ Brown |
The Journal of biological chemistry | 2001 |
Rho and Rho-associated Kinase Modulate the Tyrosine Kinase PYK2 in T-cells through Regulation of the Activity of the Integrin LFA-1
JL Rodrı́guez-Fernández, L Sánchez-Martı́n, M Rey, M Vicente-Manzanares, S Narumiya, J Teixidó, F Sánchez-Madrid, C Cabañas |
The Journal of biological chemistry | 2001 |
Activation-enhanced α IIb β 3 -Integrin–Cytoskeleton Interactions Outside of Focal Contacts Require the α-Subunit
DF Kucik, TE O'Toole, A Zheleznyak, DK Busettini, EJ Brown, JS Brugge |
Molecular biology of the cell | 2001 |
Activation of α v β3-Vitronectin Binding Is a Multistage Process in which Increases in Bond Strength Are Dependent on Y747 and Y759 in the Cytoplasmic Domain of β3
D Boettiger, F Huber, L Lynch, S Blystone, JS Brugge |
Molecular biology of the cell | 2001 |
Physiology of Inflammation
K Ley |
2001 | |
A Dominant Jurkat T Cell Mutation That Inhibits LFA-1-Mediated Cell Adhesion Is Associated with Increased Cell Growth
LK Cherry, KS Weber, LB Klickstein |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
CD18 Activation Epitopes Induced by Leukocyte Activation
CR Beals, AC Edwards, RJ Gottschalk, TW Kuijpers, DE Staunton |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Platelet/polymorphonuclear leukocyte adhesion: a new role for SRC kinases in Mac-1 adhesive function triggered by P-selectin
P Piccardoni, R Sideri, S Manarini, A Piccoli, N Martelli, G de Gaetano, C Cerletti, V Evangelista |
Blood | 2001 |
Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-70
MM Morgan, CM Labno, GA Seventer, MF Denny, DB Straus, JK Burkhardt |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Cellular Activation of Leukocyte Function-Associated Antigen-1 and Its Affinity Are Regulated at the I Domain Allosteric Site
ML Lupher, EA Harris, CR Beals, LM Sui, RC Liddington, DE Staunton |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Subversion of integrins by enteropathogenic Yersinia
RR Isberg, P Barnes |
Journal of cell science | 2001 |
Role of adhesion molecules in activation signaling in T lymphocytes
M L Dustin |
Journal of Clinical Immunology | 2001 |
Expression of MacMARCKS Restores Cell Adhesion to ICAM-1-Coated Surface
L Yue, Z Bao, J Li |
Cell Communication and Adhesion | 2000 |
Avidity regulation of integrins: the driving force in leukocyte adhesion
Y Kooyk, CG Figdor |
Current Opinion in Cell Biology | 2000 |
Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition
PA der Merwe, SJ Davis, AS Shaw, ML Dustin |
Seminars in Immunology | 2000 |
Signaling Takes Shape in the Immune System
ML Dustin, AC Chan |
Cell | 2000 |
Bi-directional signal transduction by integrin receptors
MG Coppolino, S Dedhar |
The International Journal of Biochemistry & Cell Biology | 2000 |
The Leukocyte Integrins
ES Harris, TM McIntyre, SM Prescott, GA Zimmerman |
The Journal of biological chemistry | 2000 |
Integrin-Mediated Drug Resistance in Multiple Myeloma
JS Damiano, WS Dalton |
Leukemia & Lymphoma | 2000 |
R-Ras Contains a Proline-rich Site That Binds to SH3 Domains and Is Required for Integrin Activation by R-Ras
B Wang, JX Zou, B Ek-Rylander, E Ruoslahti |
The Journal of biological chemistry | 2000 |
Evaluation of Prototype Transmembrane 4 Superfamily Protein Complexes and Their Relation to Lipid Rafts
C Claas, CS Stipp, ME Hemler |
The Journal of biological chemistry | 2000 |
Macrophage-enriched Myristoylated Alanine-rich C Kinase Substrate and Its Phosphorylation Is Required for the Phorbol Ester-stimulated Diffusion of β 2 Integrin Molecules
X Zhou, J Li |
The Journal of biological chemistry | 2000 |
Protein Kinase C-regulated Dynamitin-Macrophage-enriched Myristoylated Alanine-Rice C Kinase Substrate Interaction Is Involved in Macrophage Cell Spreading
L Yue, S Lu, J Garces, T Jin, J Li |
The Journal of biological chemistry | 2000 |
Distinct Mechanisms of α 5 β 1 Integrin Activation by Ha-Ras and R-Ras
T Kinashi, K Katagiri, S Watanabe, B Vanhaesebroeck, J Downward, K Takatsu |
The Journal of biological chemistry | 2000 |
The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling
ML Dustin, JA Cooper |
Nature Immunology | 2000 |
Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling
DA Calderwood, SJ Shattil, MH Ginsberg |
The Journal of biological chemistry | 2000 |
Dynamic Regulation of Activated Leukocyte Cell Adhesion Molecule–mediated Homotypic Cell Adhesion through the Actin Cytoskeleton
JM Nelissen, IM Peters, BG de Grooth, Y van Kooyk, CG Figdor, M Schwartz |
Molecular biology of the cell | 2000 |
Pulmonary Immunotoxicology
MD Cohen, JT Zelikoff, RB Schlesinger |
2000 | |
The parting of the endothelium: miracle, or simply a junctional affair?
C Johnson-Leger, M Aurrand-Lions, BA Imhof |
Journal of cell science | 2000 |
α 4 β 1 Integrin/VCAM-1 Interaction Activates α L β 2 Integrin-Mediated Adhesion to ICAM-1 in Human T Cells
JR Chan, SJ Hyduk, MI Cybulsky |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule–1
ER Hentzen, S Neelamegham, GS Kansas, JA Benanti, LV McIntire, CW Smith, SI Simon |
Blood | 2000 |
The LFA-1 Integrin Supports Rolling Adhesions on ICAM-1 Under Physiological Shear Flow in a Permissive Cellular Environment
A Sigal, DA Bleijs, V Grabovsky, SJ van Vliet, O Dwir, CG Figdor, Y van Kooyk, R Alon |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Role of the cytoskeleton in rapid activation of CD11b/CD18 function and its subsequent downregulation in neutrophils
SI Anderson, NA Hotchin, GB Nash |
Journal of cell science | 2000 |
Low-affinity LFA-1/ICAM-3 interactions augment LFA-1/ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1
DA Bleijs, ME Binnerts, SJ van Vliet, CG Figdor, Y van Kooyk |
Journal of cell science | 2000 |
Soluble VCAM-1 binding to α4 integrins is cell-type specific and activation dependent and is disrupted during apoptosis in T cells
DM Rose, PM Cardarelli, RR Cobb, MH Ginsberg |
Blood | 2000 |
Nerve growth factor stimulates coupling of beta1 integrin to distinct transport mechanisms in the filopodia of growth cones
PW Grabham, M Foley, A Umeojiako, DJ Goldberg |
Journal of cell science | 2000 |
Phosphorylated form of MacMARCKS is essential to LFA-1-dependent cell-cell adhesion of U937 monocytic cells
L Yue, Z Bao, J Li |
Journal of Cellular Physiology | 1999 |
The cytoskeletal association of CD11/CD18 leukocyte integrins in phorbol ester-activated cells correlates with CD18 phosphorylation
L Valmu, S Fagerholm, H Suila, CG Gahmberg |
European Journal of Immunology | 1999 |
Regulation of integrin function by T cell activation
T Zeil, WJ Kivens, SA Kellermann, Y Shimizu |
Immunologic Research | 1999 |
Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization
MS Chen, KS Tung, SA Coonrod, Y Takahashi, D Bigler, A Chang, Y Yamashita, PW Kincade, JC Herr, JM White |
Proceedings of the National Academy of Sciences | 1999 |
Function of the cytoskeleton in human neutrophils and methods for evaluation
M Torres, TD Coates |
Journal of Immunological Methods | 1999 |
Advances in Cellular and Molecular Biology of Membranes and Organelles
MA Horwitz, DL Clemens |
Advances in Cellular and Molecular Biology of Membranes and Organelles | 1999 |
PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells
K Cichowski, M J Orsini, L F Brass |
Biochimica et Biophysica Acta | 1999 |
Primary Megakaryocytes Reveal a Role for Transcription Factor Nf-E2 in Integrin αiibβ3 Signaling
M Shiraga, A Ritchie, S Aidoudi, V Baron, D Wilcox, G White, B Ybarrondo, G Murphy, A Leavitt, S Shattil |
The Journal of Cell Biology | 1999 |
Evidence that Distinct States of the Integrin α6β1 Interact with Laminin and an ADAM
MS Chen, EA Almeida, AP Huovila, Y Takahashi, LM Shaw, AM Mercurio, JM White |
The Journal of Cell Biology | 1999 |
Enhancement of Endothelial Cell Migration and in Vitro Tube Formation by Tap20, a Novel β5 Integrin–Modulating, Pkcθ-Dependent Protein
S Tang, Y Gao, JA Ware |
The Journal of Cell Biology | 1999 |
The Platelet Cytoskeleton Regulates the Affinity of the Integrin α IIb β 3 for Fibrinogen
JS Bennett, S Zigmond, G Vilaire, ME Cunningham, B Bednar |
The Journal of biological chemistry | 1999 |
Immune Complex-induced Integrin Activation and L-plastin Phosphorylation Require Protein Kinase A
J Wang, EJ Brown |
The Journal of biological chemistry | 1999 |
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation
DA Calderwood, R Zent, R Grant, DJ Rees, RO Hynes, MH Ginsberg |
The Journal of biological chemistry | 1999 |
The Actin Cytoskeleton Regulates LFA-1 Ligand Binding through Avidity Rather than Affinity Changes
Y Kooyk, SJ van Vliet, CG Figdor |
The Journal of biological chemistry | 1999 |
Mechanisms and Consequences of Affinity Modulation of Integrin α V β 3 Detected with a Novel Patch-engineered Monovalent Ligand
N Pampori, T Hato, DG Stupack, S Aidoudi, DA Cheresh, GR Nemerow, SJ Shattil |
The Journal of biological chemistry | 1999 |
Specific Activation of Leukocyte β2 Integrins Lymphocyte Function–associated Antigen-1 and Mac-1 by Chemokines Mediated by Distinct Pathways via the α Subunit Cytoplasmic Domains
KS Weber, LB Klickstein, C Weber, CH Heldin |
Molecular biology of the cell | 1999 |
Disruption of filamentous actin inhibits human macrophage fusion
KR DeFIFE, CR Jenney, E Colton, JM Anderson |
The FASEB Journal | 1999 |
Regulation of integrin function by T cell activation: Points of Convergence and Divergence
T Zeil, WJ Kivens, SA Kellermann, Y Shimizu |
Immunologic Research | 1999 |
Integrin associated proteins
ME Hemler |
Current Opinion in Cell Biology | 1998 |
Integrin affinity modulation
PE Hughes, M Pfaff |
Trends in Cell Biology | 1998 |
β1 integrin cytoplasmic domain regulates the constitutive conformation detected by MAb 15/7, but not the ligand-induced conformation
D Crommie, ME Hemler |
Journal of Cellular Biochemistry | 1998 |
Three dimensional single-particle tracking with nanometer resolution
IM Peters, BG de Grooth, JM Schins, CG Figdor, J Greve |
Review of Scientific Instruments | 1998 |
Are changes in integrin affinity and conformation overemphasized?
G Bazzoni, ME Hemler |
Trends in Biochemical Sciences | 1998 |
Adhesion and Signaling Mediated by the Cytoplasmic Tails of Leucocyte Integrins
YV Kooyk, M Lub, CG Figdor |
Cell Communication and Adhesion | 1998 |
Making a Little Affinity Go a Long Way: A Topological View of LFA-1 Regulation
ML Dustin |
Cell Communication and Adhesion | 1998 |
Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3
T Hato, N Pampori, SJ Shattil |
The Journal of Cell Biology | 1998 |
Interactions of the cytoplasmic domain of P-selectin with clathrin-coated pits enhance leukocyte adhesion under flow
H Setiadi, G Sedgewick, SL Erlandsen, RP McEver |
The Journal of Cell Biology | 1998 |
Cytoskeletal interactions with the leukocyte integrin beta2 cytoplasmic tail. Activation-dependent regulation of associations with talin and alpha-actinin
R Sampath, PJ Gallagher, FM Pavalko |
The Journal of biological chemistry | 1998 |
A role for the actin-bundling protein L-plastin in the regulation of leukocyte integrin function
SL Jones, J Wang, CW Turck, EJ Brown |
Proceedings of the National Academy of Sciences | 1998 |
LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain
MP Stewart, A McDowall, N Hogg |
The Journal of Cell Biology | 1998 |
Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin
TV Byzova, EF Plow |
The Journal of Cell Biology | 1998 |
Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils
SL Jones, UG Knaus, GM Bokoch, EJ Brown |
The Journal of biological chemistry | 1998 |
LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca 2+ -dependent Protease, Calpain
MP Stewart, A McDowall, N Hogg |
The Journal of Cell Biology | 1998 |
Activation of α V β 3 on Vascular Cells Controls Recognition of Prothrombin
TV Byzova, EF Plow |
The Journal of Cell Biology | 1998 |
Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin α IIb β 3
T Hato, N Pampori, SJ Shattil |
The Journal of Cell Biology | 1998 |
Regulation of Integrin-Mediated Adhesion by Muscarinic Acetylcholine Receptors and Protein Kinase C in Small Cell Lung Carcinoma
RL Quigley, SH Shafer, CL Williams |
Chest | 1998 |
Regulation of αIIbβ3 Function in Human B Lymphocytes
W Qi, E Loh, G Vilaire, JS Bennett |
The Journal of biological chemistry | 1998 |
Cytoskeletal Interactions with the Leukocyte Integrin β2 Cytoplasmic Tail: ACTIVATION-DEPENDENT REGULATION OF ASSOCIATIONS WITH TALIN AND α-ACTININ
R Sampath, PJ Gallagher, FM Pavalko |
The Journal of biological chemistry | 1998 |
The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity
JG van de Winkel, PM Hogarth |
1998 | |
Integrin Signaling: The Platelet Paradigm
SJ Shattil, H Kashiwagi, N Pampori |
Blood | 1998 |
RhoA and the Function of Platelet Integrin αIIbβ3
L Leng, H Kashiwagi, XD Ren, SJ Shattil |
Blood | 1998 |
Constitutive Chemokine Production Results in Activation of Leukocyte Function-Associated Antigen-1 on Adult T-Cell Leukemia Cells
Y Tanaka, S Mine, CG Figdor, A Wake, H Hirano, J Tsukada, M Aso, K Fujii, K Saito, Y van Kooyk, S Eto |
Blood | 1998 |
Integrin α chain cytoplasmic tails regulate “antibody-redirected” cell adhesion, independently of ligand binding
JB Weitzman, C Pujades, ME Hemler |
European Journal of Immunology | 1997 |
Emerging paradigms of integrin ligand binding and activation
T Sugimori, DL Griffith, MA Arnaout |
Kidney International | 1997 |
Leukocyte Adhesion. Structure and Function of Human Leukocyte beta2-Integrins and their Cellular Ligands
CG Gahmberg, M Tolvanen, P Kotovuori |
European Journal of Biochemistry | 1997 |
Role of ligands in the activation of LFA-1
CD Buckley, ED Ferguson, AJ Littler, D Bossy, DL Simmons |
European Journal of Immunology | 1997 |
Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding
RL Yauch, DP Felsenfeld, SK Kraeft, LB Chen, MP Sheetz, ME Hemler |
Journal of Experimental Medicine | 1997 |
The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow
R Knorr, ML Dustin |
Journal of Experimental Medicine | 1997 |
Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1
M Lub, Y Kooyk, SJ van Vliet, CG Figdor |
Molecular biology of the cell | 1997 |
Classification of `activation' antibodies against integrin β1 chain
J Tsuchida, S Ueki, Y Saito, J Takagi |
FEBS Letters | 1997 |
The Lymphocyte Function-associated Antigen 1 I Domain Is a Transient Binding Module for Intercellular Adhesion Molecule (ICAM)-1 and ICAM-3 in Hydrodynamic Flow
R Knorr, ML Dustin |
Journal of Experimental Medicine | 1997 |
Mutational Evidence for Control of Cell Adhesion Through Integrin Diffusion/Clustering, Independent of Ligand Binding
RL Yauch, DP Felsenfeld, SK Kraeft, LB Chen, MP Sheetz, ME Hemler |
Journal of Experimental Medicine | 1997 |
Muscle β1D Integrin Reinforces the Cytoskeleton–Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing
AM Belkin, SF Retta, OY Pletjushkina, F Balzac, L Silengo, R Fassler, VE Koteliansky, K Burridge, G Tarone |
The Journal of Cell Biology | 1997 |
Requirement of Integrin β 3 Tyrosine 747 for β 3 Tyrosine Phosphorylation and Regulation of α v β 3 Avidity
SD Blystone, MP Williams, SE Slater, EJ Brown |
The Journal of biological chemistry | 1997 |
Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity
ML Dustin, DE Golan, DM Zhu, JM Miller, W Meier, EA Davies, PA van der Merwe |
The Journal of biological chemistry | 1997 |
Where the outside meets the inside: integrins as activators and targets of signal transduction cascades
E Brown, N Hogg |
Immunology Letters | 1996 |
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