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Citations to this article

Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure.
R M Marrades, … , R Rodríguez-Roisin, P D Wagner
R M Marrades, … , R Rodríguez-Roisin, P D Wagner
Published May 1, 1996
Citation Information: J Clin Invest. 1996;97(9):2092-2100. https://doi.org/10.1172/JCI118646.
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Research Article

Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure.

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Abstract

Erythropoietin (rHuEPO) has proven to be effective in the treatment of anemia of chronic renal failure (CRF). Despite improving the quality of life, peak oxygen uptake after rHuEPO therapy is not improved as much as the increase in hemoglobin concentration ([Hb)] would predict. We hypothesized that this discrepancy is due to failure of O2 transport rates to rise in a manner proportional to [Hb]. To test this, eight patients with CRF undergoing regular hemodialysis were studied pre- and post-rHuEPO ([Hb] = 7.5 +/- 1.0 vs. 12.5 +/- 1.0 g x dl-1) using a standard incremental cycle exercise protocol. A group of 12 healthy sedentary subjects of similar age and anthropometric characteristics served as controls. Arterial and femoral venous blood gas data were obtained and coupled with simultaneous measurements of femoral venous blood flow (Qleg) by thermodilution to obtain O2 delivery and oxygen uptake (VO2). Despite a 68% increase in [Hb], peak VO2 increased by only 33%. This could be explained largely by reduced peak leg blood flow, limiting the gain in O2 delivery to 37%. At peak VO2, after rHuEPO, O2 supply limitation of maximal VO2 was found to occur, permitting the calculation of a value for muscle O2 conductance from capillary to mitochondria (DO2). While DO2 was slightly improved after rHuEPO, it was only 67% of that of sedentary control subjects. This kept maximal oxygen extraction at only 70%. Two important conclusions can be reached from this study. First, the increase in [Hb] produced by rHuEPO is accompanied by a significant reduction in peak blood flow to exercising muscle, which limits the gain in oxygen transport. Second, even after restoration of [Hb], O2 conductance from the muscle capillary to the mitochondria remains considerably below normal.

Authors

R M Marrades, J Roca, J M Campistol, O Diaz, J A Barberá, J V Torregrosa, J R Masclans, A Cobos, R Rodríguez-Roisin, P D Wagner

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1996 1979 Total
Citations: 1 2 1 1 6 1 1 1 1 1 5 1 5 5 7 5 4 9 4 3 6 3 1 4 1 1 1 81
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2007 (5)

Title and authors Publication Year
Physiological Basis of Fatigue
WJ Evans, CP Lambert
American Journal of Physical Medicine & Rehabilitation 2007
Randomized Controlled Trial of Intradialytic Resistance Training to Target Muscle Wasting in ESRD: The Progressive Exercise for Anabolism in Kidney Disease (PEAK) Study
B Cheema, H Abas, B Smith, A OSullivan, M Chan, A Patwardhan, J Kelly, A Gillin, G Pang, B Lloyd, MF Singh
American Journal of Kidney Diseases 2007
Myosin heavy-chain isoform distribution, fibre-type composition and fibre size in skeletal muscle of patients on haemodialysis
S Molsted, I Eidemak, H Sorensen, J Kristensen, A Harrison, JL Andersen
Scandinavian Journal of Urology and Nephrology 2007
Pulmonary Rehabilitation
AL Ries, GS Bauldoff, BW Carlin, R Casaburi, CF Emery, DA Mahler, B Make, CL Rochester, R ZuWallack, C Herrerias
Chest 2007
Physical Exercise in Dialysis Patients
GC Kosmadakis, N Zerefos
The International Journal of Artificial Organs 2007

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