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P Reboul, … , J M Cloutier, J Martel-Pelletier
Published May 1, 1996
Citation Information: J Clin Invest. 1996;97(9):2011-2019. https://doi.org/10.1172/JCI118636.
Citation Information: J Clin Invest. 1996;97(9):2011-2019. https://doi.org/10.1172/JCI118636.
Abstract
Recently, a new human collagenase, collagenase-3 has been identified. Since collagen changes are of particular importance in cartilage degeneration, we investigated if collagenase-3 plays a role in osteoarthritis (OA). Reverse transcriptase-PCR analysis revealed that in articular tissues collagenase-3 was expressed by the chondrocytes but not by the synoviocytes. Northern blot analysis of the chondrocyte mRNA revealed the presence of two major gene transcripts of 3.0 and 2.5 kb, and a third one of 2.2 kb was occasionally present. Compared to normal, OA showed a significantly higher (3.0 kb, P < or = 0.05; 2.5 kb, P < or = 0.03) level of collagenase-3 mRNA expression. Collagenase-3 had a higher catalytic velocity tate (about fivefold) than collagenase-1 on type II collagen. With the use of two specific antibodies, we showed that human chondrocytes had the ability to produce collagenase-3 as a proenzyme and as a glycosylated doublet. The chondrocyte collagenase-3 protein is produced in a significantly higher (P < or = 0.04) level in OA (approximately 9.5-fold) than in normal. The synthesis and expression of this new collagenase could also be modulated by two proinflammatory cytokines, IL-1 beta and TNF-alpha, in a time- and dose-dependent manner. This study provides novel and interesting data on collagenase-3 expression and synthesis in human cartilage cells and suggest its involvement in human OA cartilage patho-physiology.
Authors
P Reboul, J P Pelletier, G Tardif, J M Cloutier, J Martel-Pelletier
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Matrilin-3 switches from anti- to pro-anabolic upon integration to the extracellular matrix
JB Vincourt, S Etienne, L Grossin, J Cottet, C Bantsimba-Malanda, P Netter, D Mainard, V Libante, P Gillet, J Magdalou |
Matrix Biology | 2012 |
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Chondroprotective and anti-inflammatory effects of sesamin
T Phitak, P Pothacharoen, J Settakorn, W Poompimol, B Caterson, P Kongtawelert |
Phytochemistry | 2012 |
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Role of S100A12 in the pathogenesis of osteoarthritis
M Nakashima, T Sakai, H Hiraiwa, T Hamada, T Omachi, Y Ono, N Inukai, S Ishizuka, T Matsukawa, T Oda, A Takamatsu, S Yamashita, N Ishiguro |
Biochemical and Biophysical Research Communications | 2012 |
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Evaluation of the association between runt-related transcription factor 2 expression and intervertebral disk aging in dogs
H Itoh, Y Hara, M Tagawa, T Kato, H Ochi, D Koga, A Okawa, Y Asou |
American Journal of Veterinary Research | 2012 |
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A modified colorimetric method of gelatinolytic assay using bacterial collagenase type II as a model
M Osathanunkul, K Buddhachat, S Chomdej |
Analytical Biochemistry | 2012 |
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Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes
MK Kaneva, MJ Kerrigan, P Grieco, GP Curley, IC Locke, SJ Getting |
British Journal of Pharmacology | 2012 |
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Osteopontin Level in Synovial Fluid Is Associated with the Severity of Joint Pain and Cartilage Degradation after Anterior Cruciate Ligament Rupture
M Yamaga, K Tsuji, K Miyatake, J Yamada, K Abula, YJ Ju, I Sekiya, T Muneta, JJ Gagnier |
PloS one | 2012 |
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High expression of TNF alpha is associated with −308 and −238 TNF alpha polymorphisms in knee osteoarthritis
JF Muñoz-Valle, E Oregón-Romero, H Rangel-Villalobos, GE Martínez-Bonilla, E Castañeda-Saucedo, L Salgado-Goytia, MA Leyva-Vázquez, B Illades-Aguiar, L del Carmen Alarcón-Romero, M Espinoza-Rojo, I Parra-Rojas |
Clinical and Experimental Medicine | 2012 |
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Proteases involved in cartilage matrix degradation in osteoarthritis
L Troeberg, H Nagase |
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics | 2011 |
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Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis
M Wang, J Shen, H Jin, HJ Im, J Sandy, D Chen |
Annals of the New York Academy of Sciences | 2011 |
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E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress
M Otero, DA Plumb, K Tsuchimochi, CL Dragomir, K Hashimoto, H Peng, E Olivotto, M Bevilacqua, L Tan, Z Yang, Y Zhan, P Oettgen, Y Li, KB Marcu, MB Goldring |
The Journal of biological chemistry | 2011 |
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Proteinase-activated Receptor-2 Gene Disruption Limits the Effect of Osteoarthritis on Cartilage in Mice: A Novel Target in Joint Degradation
N Amiable, J Martel-Pelletier, B Lussier, SK Tat, JP Pelletier, C Boileau |
The Journal of rheumatology | 2011 |
|
Age-dependent alteration of TGF-β signalling in osteoarthritis
PM van der Kraan, MJ Goumans, EB Davidson, P Dijke |
Cell and Tissue Research | 2011 |
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Gene profiling of the rat medial collateral ligament during early healing using microarray analysis
CS Chamberlain, SH Brounts, DG Sterken, KI Rolnick, GS Baer, R Vanderby |
Journal of applied physiology | 2011 |
|
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression
J Schwager, U Hoeller, S Wolfram, N Richard |
BMC complementary and alternative medicine | 2011 |
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Biological Basis of Exercise-Based Treatments for Musculoskeletal Conditions
F Ambrosio, A Tarabishy, F Kadi, EH Brown, G Sowa |
PM&R | 2011 |
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Unique biomaterial compositions direct bone marrow stem cells into specific chondrocytic phenotypes corresponding to the various zones of articular cartilage
LH Nguyen, AK Kudva, NL Guckert, KD Linse, K Roy |
Biomaterials | 2011 |
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Interleukin-1 beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle
K Tanimoto, Y Iwabuchi, Y Tanne, T Kamiya, T Inubushi, R Kunimatsu, T Mitsuyoshi, K Tanne |
Archives of Oral Biology | 2011 |
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Effect of Low-Intensity Pulsed Ultrasound on MMP-13 and MAPKs Signaling Pathway in Rabbit Knee Osteoarthritis
X Li, J Li, K Cheng, Q Lin, D Wang, H Zhang, H An, M Gao, A Chen |
Cell Biochemistry and Biophysics | 2011 |
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Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis
YJ Woo, YB Joo, YO Jung, JH Ju, ML Cho, HJ Oh, JY Jhun, MK Park, JS Park, CM Kang, MS Sung, SH Park, HY Kim, JK Min |
Experimental & molecular medicine | 2011 |
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Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes
D Sbardella, GF Fasciglione, M Gioia, C Ciaccio, GR Tundo, S Marini, M Coletta |
Molecular Aspects of Medicine | 2011 |
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Matrix Metalloproteinases
W Bode, K Maskos |
Encyclopedia of Inorganic and Bioinorganic Chemistry | 2011 |
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Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis
MB Goldring, M Otero, DA Plumb, C Dragomir, M Favero, KE Hachem, K Hashimoto, HI Roach, E Olivotto, RM Borzì, KB Marcu |
European cells & materials | 2011 |
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Gene profiling of the rat medial collateral ligament during early healing using microarray analysis
CS Chamberlain, SH Brounts, DG Sterken, KI Rolnick, GS Baer, R Vanderby |
Journal of applied physiology | 2011 |
|
Cartilage Imaging
TM Link |
2011 | |
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Attenuation of osteoarthritis progression by reduction of the discoidin domain receptor 2 in mice
L Xu, J Servais, I Polur, D Kim, PL Lee, K Chung, Y Li |
Arthritis & Rheumatism | 2010 |
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A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis
PM van der Kraan, EN Davidson, WB van Berg |
Arthritis Research & Therapy | 2010 |
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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
M Kapoor, J Martel-Pelletier, D Lajeunesse, JP Pelletier, H Fahmi |
Nature Reviews Rheumatology | 2010 |
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Collagen-induced expression of collagenase-3 by primary chondrocytes is mediated by integrin 1 and discoidin domain receptor 2: a protein kinase C-dependent pathway
LA Vonk, BZ Doulabi, C Huang, MN Helder, V Everts, RA Bank |
Rheumatology | 2010 |
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Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages
S Ströbel, M Loparic, D Wendt, AD Schenk, C Candrian, RL Lindberg, F Moldovan, A Barbero, I Martin |
Arthritis Research & Therapy | 2010 |
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Protein geranylgeranylation controls collagenase expression in osteoarthritic cartilage
FM Sverdrup, MP Yates, LE Vickery, JA Klover, LR Song, CP Anglin, TP Misko |
Osteoarthritis and Cartilage | 2010 |
|
Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers--are they the cause or the consequence of the disease?
MA Karsdal, K Henriksen, DJ Leeming, T Woodworth, E Vassiliadis, AC Bay-Jensen |
Clinical Biochemistry | 2010 |
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Arthrose — zum aktuellen Kenntnisstand über die Ätiologie, Diagnose und Therapie
S Mayer, K Vitzthum, N Schöffel, DA Groneberg, M Spallek |
Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis
SK Tat, N Amiable, JP Pelletier, C Boileau, D Lajeunesse, N Duval, J Martel-Pelletier |
Rheumatology | 2009 |
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Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts
N Amiable, SK Tat, D Lajeunesse, N Duval, JP Pelletier, J Martel-Pelletier, C Boileau |
Bone | 2009 |
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Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
SK Tat, JP Pelletier, N Amiable, C Boileau, M Lavigne, J Martel-Pelletier |
Arthritis Research & Therapy | 2009 |
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Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1
AE Nugent, DM Speicher, I Gradisar, DL McBurney, A Baraga, KJ Doane, WE Horton |
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society | 2009 |
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Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development
MA Karsdal, K Henriksen, DJ Leeming, P Mitchell, K Duffin, N Barascuk, L Klickstein, P Aggarwal, O Nemirovskiy, I Byrjalsen, P Qvist, AC Bay-Jensen, EB Dam, SH Madsen, C Christiansen |
Biomarkers | 2009 |
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Clinical efficacy and safety of Gubitong Recipe (骨痹通方) in treating osteoarthritis of knee joint
Q Tao, Y Xu, D Jin, X Yan |
Chinese Journal of Integrative Medicine | 2009 |
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Involvement of the notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage
R Blaise, M Mahjoub, C Salvat, U Barbe, C Brou, MT Corvol, JF Savouret, F Rannou, F Berenbaum, P Bausero |
Arthritis & Rheumatism | 2009 |
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Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits
D Takahashi, N Iwasaki, S Kon, Y Matsui, T Majima, A Minami, T Uede |
Arthritis & Rheumatism | 2009 |
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N-acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritis
S Nakagawa, Y Arai, O Mazda, T Kishida, KA Takahashi, K Sakao, M Saito, K Honjo, J Imanishi, T Kubo |
Journal of Orthopaedic Research | 2009 |
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The effects of p-hydroxycinnamaldehyde from Alpinia galanga extracts on human chondrocytes
T Phitak, K Choocheep, P Pothacharoen, W Pompimon, B Premanode, P Kongtawelert |
Phytochemistry | 2009 |
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A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models
VM Baragi, G Becher, AM Bendele, R Biesinger, H Bluhm, J Boer, H Deng, R Dodd, M Essers, T Feuerstein, BM Gallagher, C Gege, M Hochgürtel, M Hofmann, A Jaworski, L Jin, A Kiely, B Korniski, H Kroth, D Nix, B Nolte, D Piecha, TS Powers, F Richter, M Schneider, C Steeneck, I Sucholeiki, A Taveras, A Timmermann, JV Veldhuizen, J Weik, X Wu, B Xia |
Arthritis & Rheumatism | 2009 |
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Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice
Y Matsui, N Iwasaki, S Kon, D Takahashi, J Morimoto, Y Matsui, DT Denhardt, S Rittling, A Minami, T Uede |
Arthritis & Rheumatism | 2009 |
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Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
G Tardif, D Hum, JP Pelletier, N Duval, J Martel-Pelletier |
BMC musculoskeletal disorders | 2009 |
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Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis
N Chabane, N Zayed, M Benderdour, J Martel-Pelletier, JP Pelletier, N Duval, H Fahmi |
Arthritis Research & Therapy | 2009 |
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Involvement of p38 MAPK in regulation of MMP13 mRNA in chondrocytes in response to surviving stress to endoplasmic reticulum
K Hamamura, MB Goldring, H Yokota |
Archives of Oral Biology | 2009 |
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Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors
A Heim-Riether, SJ Taylor, S Liang, DA Gao, Z Xiong, EM August, BK Collins, BT Farmer, K Haverty, M Hill-Drzewi, HD Junker, SM Margarit, N Moss, T Neumann, JR Proudfoot, LS Keenan, R Sekul, Q Zhang, J Li, NA Farrow |
Bioorganic & Medicinal Chemistry Letters | 2009 |
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Fisiopatolog��a de la artrosis
X Chevalier |
EMC - Aparato Locomotor | 2009 |
|
The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study
G Tardif, JP Pelletier, C Boileau, J Martel-Pelletier |
Osteoarthritis and Cartilage | 2009 |
|
Advanced Osteoarthritis in Humans Is Associated With Altered Collagen VI Expression and Upregulation of ER-stress Markers Grp78 and Bag-1
AE Nugent, DM Speicher, I Gradisar, DL McBurney, A Baraga, KJ Doane, WE Horton |
Journal of Histochemistry & Cytochemistry | 2009 |
|
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism
MB Goldring, M Otero, K Tsuchimochi, K Ijiri, Y Li |
Annals of the rheumatic diseases | 2008 |
|
Quinazolinones and Pyrido[3,4- d ]pyrimidin-4-ones as Orally Active and Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis
JJ Li, J Nahra, AR Johnson, A Bunker, P OBrien, WS Yue, DF Ortwine, CF Man, V Baragi, K Kilgore, RD Dyer, HK Han |
Journal of Medicinal Chemistry | 2008 |
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Rôle des récepteurs activés par les proliférateurs de peroxysomes (PPAR) en physiopathologie articulaire : intérêts et limites des agonistes
JY Jouzeau, D Moulin, M Koufany, S Sebillaud, A Bianchi, P Netter |
Journal de la Société de Biologie | 2008 |
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Inhibition of interleukin-1β-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2
N Zayed, H Afif, N Chabane, L Mfuna-Endam, M Benderdour, J Martel-Pelletier, JP Pelletier, RK Motiani, M Trebak, N Duval, H Fahmi |
Arthritis & Rheumatism | 2008 |
|
Inhibition of Matrix Metalloproteinases Enhances In Vitro Repair of the Meniscus
AL McNulty, JB Weinberg, F Guilak |
Clinical Orthopaedics and Related Research® | 2008 |
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The enhancement of chondrogenic differentiation of human mesenchymal stem cells by enzymatically regulated RGD functionalities
CN Salinas, KS Anseth |
Biomaterials | 2008 |
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Matrix metalloproteinase and its inhibitor in temporomandibular joint osteoarthrosis after indirect trauma in young goats
Yan-Liang Wang, Xin-Jun Li, Rui-Feng Qin, De-Lin Lei, Yan-Pu Liu, Gao-Yi Wu, Yong-Jie Zhang, Yan-Jin, Da-Zhang Wang, Kai-Jin Hu |
British Journal of Oral and Maxillofacial Surgery | 2008 |
|
Characterization of metalloprotease cleavage products of human articular cartilage
EY Zhen, IJ Brittain, DA Laska, PG Mitchell, EU Sumer, MA Karsdal, KL Duffin |
Arthritis & Rheumatism | 2008 |
|
Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage
Y Sawaji, J Hynes, T Vincent, J Saklatvala |
Arthritis & Rheumatism | 2008 |
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The cartilage chondrolytic mechanism of fibronectin fragments involves MAP kinases: comparison of three fragments and native fibronectin
L Ding, D Guo, GA Homandberg |
Osteoarthritis and Cartilage | 2008 |
|
Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis
MB Ellman, HS An, P Muddasani, HJ Im |
Gene | 2008 |
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Cartilage in normal and osteoarthritis conditions
J Martel-Pelletier, C Boileau, JP Pelletier, PJ Roughley |
Best Practice & Research Clinical Rheumatology | 2008 |
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Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis
J Monfort, G Tardif, P Roughley, P Reboul, C Boileau, PN Bishop, JP Pelletier, J Martel-Pelletier |
Osteoarthritis and Cartilage | 2008 |
|
Principles of Bone Biology
CJ Rosen, T Niu |
Principles of Bone Biology | 2008 |
|
Physiopathologie de l'arthrose
X Chevalier |
EMC - Appareil locomoteur | 2008 |
|
In vitro expansion affects the response of chondrocytes to mechanical stimulation
RH Das, H Jahr, JA Verhaar, JC der Linden, GJ Osch, H Weinans |
Osteoarthritis and Cartilage | 2008 |
|
Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1β-stimulated chondrocytes – study in hypoxic alginate bead cultures
F Legendre, C Baugé, R Roche, AS Saurel, JP Pujol |
Osteoarthritis and Cartilage | 2008 |
|
α-MSH inhibits TNF-α-induced matrix metalloproteinase-13 expression by modulating p38 kinase and nuclear factor κB signaling in human chondrosarcoma HTB-94 cells
SW Yoon, JS Chun, MH Sung, JY Kim, H Poo |
Osteoarthritis and Cartilage | 2008 |
|
Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes
ME Mabrouk, J Sylvester, M Zafarullah |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2007 |
|
Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease
Y Li, L Xu, BR Olsen |
Osteoarthritis and Cartilage | 2007 |
|
Activation of Interleukin-1 Signaling Cascades in Normal and Osteoarthritic Articular Cartilage
Z Fan, S Söder, S Oehler, K Fundel, T Aigner |
The American Journal of Pathology | 2007 |
|
DNA methylation in osteoarthritic chondrocytes: a new molecular target
HI Roach, T Aigner |
Osteoarthritis and Cartilage | 2007 |
|
Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage
S Naito, T Shiomi, A Okada, T Kimura, M Chijiiwa, Y Fujita, T Yatabe, K Komiya, H Enomoto, K Fujikawa, Y Okada |
Pathology International | 2007 |
|
Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments
MD Carlo, D Schwartz, EA Erickson, RF Loeser |
Free radical biology & medicine | 2007 |
|
Extracellular localization of galectin-3 has a deleterious role in joint tissues
A Janelle-Montcalm, C Boileau, F Poirier, JP Pelletier, M Guévremont, N Duval, J Martel-Pelletier, P Reboul |
Arthritis Research & Therapy | 2007 |
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Synthesis and in vitro evaluation of targeted tetracycline derivatives: Effects on inhibition of matrix metalloproteinases
A Vidal, M Sabatini, G Rolland-Valognes, P Renard, JC Madelmont, E Mounetou |
Bioorganic & Medicinal Chemistry | 2007 |
|
Progrès dans l’arthrose
X Chevalier |
Revue du Rhumatisme | 2007 |
|
Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects
AR Johnson, AG Pavlovsky, DF Ortwine, F Prior, CF Man, DA Bornemeier, CA Banotai, WT Mueller, P McConnell, C Yan, V Baragi, C Lesch, WH Roark, M Wilson, K Datta, R Guzman, HK Han, RD Dyer |
The Journal of biological chemistry | 2007 |
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Basic Fibroblast Growth Factor Activates the MAPK and NFκB Pathways That Converge on Elk-1 to Control Production of Matrix Metalloproteinase-13 by Human Adult Articular Chondrocytes
P Muddasani, JC Norman, M Ellman, AJ van Wijnen, HJ Im |
The Journal of biological chemistry | 2007 |
|
Bone and Osteoarthritis
F Bronner, MC Farach-Carson |
2007 | |
|
Stromal Cell-Derived Factor-1 Induces Matrix Metalloprotease-13 Expression in Human Chondrocytes
YC Chiu, RS Yang, KH Hsieh, YC Fong, TD Way, TS Lee, HC Wu, WM Fu, CH Tang |
Molecular pharmacology | 2007 |
|
Involvement of lipid peroxidation in osteoarthritic cartilage degradation: new evidence linking 4-hydroxynonenal to collagen and MMP-13 regulation
Barbara Morquette, Qin Shi, Patrick Lavigne, Pierre Ranger, Julio C. Fernandes, Mohamed Benderdour |
Arthritis & Rheumatism | 2006 |
|
Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes
LJ Raggatt, SC Jefcoat, I Choudhury, S Williams, M Tiku, NC Partridge |
Osteoarthritis and Cartilage | 2006 |
|
IL-1β, but not BMP-7 leads to a dramatic change in the gene expression pattern of human adult articular chondrocytes—Portraying the gene expression pattern in two donors
J Saas, J Haag, D Rueger, S Chubinskaya, F Sohler, R Zimmer, E Bartnik, T Aigner |
Cytokine | 2006 |
|
Effect of Alpinia galanga extract on cartilage degradation and on gene expression in human chondrocyte and synovial fibroblast metabolism
P Pothacharoen, K Choocheep, T Pitak, W Pompimon, B Premanode, TE Hardingham, P Kongtawelert |
Central European Journal of Biology | 2006 |
|
Functional characterization of an orphan nuclear receptor, Rev-ErbAα, in chondrocytes and its potential role in osteoarthritis
P Chaturvedi, M Pratta, K Steplewski, J Connor, S Kumar |
Arthritis & Rheumatism | 2006 |
|
Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter
Z Fan, G Tardif, C Boileau, JP Bidwell, C Geng, D Hum, A Watson, JP Pelletier, M Lavigne, J Martel-Pelletier |
Arthritis & Rheumatism | 2006 |
|
Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products
RR Yammani, CS Carlson, AR Bresnick, RF Loeser |
Arthritis & Rheumatism | 2006 |
|
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site
J Monfort, G Tardif, P Reboul, F Mineau, P Roughley, JP Pelletier, J Martel-Pelletier |
Arthritis Research & Therapy | 2006 |
|
Differential regulation of the bone morphogenic protein antagonist chordin in human normal and osteoarthritic chondrocytes
G Tardif, JP Pelletier, D Hum, C Boileau, N Duval, J Martel-Pelletier |
Annals of the rheumatic diseases | 2006 |
|
Cartilage breakdown in rheumatoid arthritis
F Rannou, M François, MT Corvol, F Berenbaum |
Joint Bone Spine | 2006 |
|
Textbook of Perinatal Medicine, Second Edition
Y Yaron, A Flake, M Johnson, M Evans |
Textbook of Perinatal Medicine, Second Edition: diagnostic and clinical aspects | 2006 |
|
Age-dependent increase of discoidin domain receptor 2 and matrix metalloproteinase 13 expression in temporomandibular joint cartilage of type IX and type XI collagen-deficient mice
NP Lam, Y Li, AB Waldman, J Brussiau, PL Lee, BR Olsen, L Xu |
Archives of Oral Biology | 2006 |
|
An etiologic model proposing that sporadic adult-onset carcinoma is extramedullary hematopoiesis
KA Schiel |
Medical Hypotheses | 2006 |
|
Collagenase-3 (MMP-13) expression by inflamed mucosa in inflammatory bowel disease
FJ Vizoso, LO González, MD Corte, MG Corte, M Bongera, A Martínez, A Martín, A Andicoechea, RR Gava |
Scandinavian Journal of Gastroenterology | 2006 |
|
Immunology of Pregnancy
G Mor |
2006 | |
|
Matrix Metalloproteinase 13 (MMP13) mutation causes Spondyloepimetaphyseal dysplasia, Missouri type (SEMDMO)
Ann M. Kennedy, Masaki Inada, Stephen M. Krane, Paul T. Christie, Brian Harding, Carlos López-Otín, Luis M. Sánchez, Anna A. J. Pannett, Andrew Dearlove, Claire Hartley, Michael H. Byrne, Anita A. C. Reed, M. Andrew Nesbit, Michael P. Whyte and Rajesh V. Thakker |
Journal of Clinical Investigation | 2005 |
|
Temporospatial expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in mouse antigen-induced arthritis
K Joronen, VM Kähäri, E Vuorio |
Histochemistry and Cell Biology | 2005 |
|
Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes
A Liacini, J Sylvester, WQ Li, M Zafarullah |
Arthritis Research & Therapy | 2005 |
|
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis
RF Loeser, RR Yammani, CS Carlson, H Chen, A Cole, HJ Im, LS Bursch, SD Yan |
Arthritis & Rheumatism | 2005 |
|
Gene expression profiling of serum- and interleukin-1β-stimulated primary human adult articular chondrocytes – A molecular analysis based on chondrocytes isolated from one donor
T Aigner, L McKenna, A Zien, Z Fan, PM Gebhard, R Zimmer |
Cytokine | 2005 |
|
Relationship between synovial fluid levels of glycosaminoglycans, hydroxyproline and general MMP activity and the presence and severity of articular cartilage change on the proximal articular surface of P1
R Boom, MR Harst, H Brommer, PA Brama, A Barneveld, PR Weeren, J DeGROOT |
Equine Veterinary Journal | 2005 |
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Increased Matrix Metalloproteinase-13 Production With Aging by Human Articular Chondrocytes in Response to Catabolic Stimuli
CB Forsyth, A Cole, G Murphy, JL Bienias, HJ Im, RF Loeser |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2005 |
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Serum matrix metalloproteinase activity relating to cartilage destruction in rheumatoid arthritis
T TAKEMURA, K KANBE, K TAKEUCHI, K INOUE, K TAKAGISHI |
APLAR Journal of Rheumatology | 2005 |
|
Collagenases in cancer
R Ala-aho, VM Kähäri |
Biochimie | 2005 |
|
The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals
KM Neil, JP Caron, MW Orth |
Journal of the American Veterinary Medical Association | 2005 |
|
Pioglitazone, a peroxisome proliferator-activated receptor ? agonist, reduces the progression of experimental osteoarthritis in guinea pigs
T Kobayashi, K Notoya, T Naito, S Unno, A Nakamura, J Martel-Pelletier, JP Pelletier |
Arthritis & Rheumatism | 2005 |
|
Oral treatment with PD-0200347, an ?2? ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes
C Boileau, J Martel-Pelletier, J Brunet, G Tardif, D Schrier, C Flory, A El-Kattan, M Boily, JP Pelletier |
Arthritis & Rheumatism | 2005 |
|
Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis
M Sabatini, C Lesur, M Thomas, A Chomel, P Anract, G Nanteuil, P Pastoureau |
Arthritis & Rheumatism | 2005 |
|
Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants
PS Chan, JP Caron, MW Orth |
American Journal of Veterinary Research | 2005 |
|
Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production
CA Manacu, J Martel-Pelletier, M Roy-Beaudry, JP Pelletier, JC Fernandes, FS Shipkolye, DR Mitrovic, F Moldovan |
Arthritis Research & Therapy | 2005 |
|
Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli
CB Forsyth, A Cole, G Murphy, JL Bienias, HJ Im, RF Loeser |
The journals of gerontology. Series A, Biological sciences and medical sciences | 2005 |
|
Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes
A Liacini, J Sylvester, M Zafarullah |
Biochemical and Biophysical Research Communications | 2005 |
|
The role of computational models in the search for the mechanical behavior and damage mechanisms of articular cartilage
W Wilson, CC Donkelaar, R Rietbergen, R Huiskes |
Medical engineering & physics | 2005 |
|
Basic Science of Articular Cartilage and Osteoarthritis
AD Pearle, RF Warren, SA Rodeo |
Clinics in Sports Medicine | 2005 |
|
Dégradation du cartilage et polyarthrite rhumatoïde
F Rannou, M François, MT Corvol, F Berenbaum |
Revue du Rhumatisme | 2005 |
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Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1β
M Gebauer, J Saas, F Sohler, J Haag, S Söder, M Pieper, E Bartnik, J Beninga, R Zimmer, T Aigner |
Osteoarthritis and Cartilage | 2005 |
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NF-κB Mediates the Stimulation of Cytokine and Chemokine Expression by Human Articular Chondrocytes in Response to Fibronectin Fragments
JI Pulai, H Chen, HJ Im, S Kumar, C Hanning, PS Hegde, RF Loeser |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
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Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo
R Ala-aho, M Ahonen, SJ George, J Heikkilä, R Grénman, M Kallajoki, VM Kähäri |
Oncogene | 2004 |
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Relaxin's induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint fibrocartilaginous explants
T Naqvi, TT Duong, G Hashem, M Shiga, Q Zhang, S Kapila |
Arthritis Research & Therapy | 2004 |
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Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts
G Tardif, D Hum, JP Pelletier, C Boileau, P Ranger, J Martel-Pelletier |
Arthritis & Rheumatism | 2004 |
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Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B4 in osteoarthritic chondrocytes: Role of transforming growth factor ? and eicosanoids
J Martel-Pelletier, F Mineau, H Fahmi, S Laufer, P Reboul, C Boileau, M Lavigne, JP Pelletier |
Arthritis & Rheumatism | 2004 |
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The Regulation of Chondrocyte Function by Proinflammatory Mediators
MB Goldring, F Berenbaum |
Clinical Orthopaedics and Related Research | 2004 |
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Collagenase-1 (MMP-1) activity in equine synovial fluid: influence of age, joint pathology, exercise and repeated arthrocentesis
PA Brama, R Boom, J DEGroot, GH Kiers, PR Weeren |
Equine Veterinary Journal | 2004 |
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Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis
F Kojima, H Naraba, S Miyamoto, M Beppu, H Aoki, S Kawai |
Arthritis Research & Therapy | 2004 |
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Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3
M Guévremont, J Martel-Pelletier, C Boileau, FT Liu, M Richard, JC Fernandes, JP Pelletier, P Reboul |
Annals of the rheumatic diseases | 2004 |
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The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway
C Boileau, JP Pelletier, G Tardif, H Fahmi, S Laufer, M Lavigne, J Martel-Pelletier |
Annals of the rheumatic diseases | 2004 |
|
The Regulation of Chondrocyte Function by Proinflammatory Mediators: Prostaglandins and Nitric Oxide
MB Goldring, F Berenbaum |
Clinical Orthopaedics and Related Research | 2004 |
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Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3)
G Tardif, P Reboul, JP Pelletier, J Martel-Pelletier |
Modern Rheumatology | 2004 |
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Matrix Metalloproteinase-13 (MMP-13, Collagenase-3) is Highly Expressed in Human Tooth Pulp
M Sulkala, V Pääkkönen, M Larmas, T Salo, L Tjäderhane |
Connective Tissue Research | 2004 |
|
Pathophysiology of osteoarthritis
J Martel-Pelletier |
Osteoarthritis and Cartilage | 2004 |
|
Matrix Metalloproteinase and Tissue Inhibitor of Matrix Metalloproteinase mRNA Levels are Specifically Altered in Torn Rotator Cuff Tendons
IK Lo, LL Marchuk, R Hollinshead, DA Hart, CB Frank |
The American journal of sports medicine | 2004 |
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Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes
J Sylvester, A Liacini, WQ Li, M Zafarullah |
Cellular Signalling | 2004 |
|
Proteases and Their Inhibitors in Cancer Metastasis
JM Foidart, RJ Muschel |
2004 | |
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Endothelin-1 promotes osteoarthritic cartilage degradation via MMP-1 and MMP-13 induction
Marjolaine Roy-Beaudry, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Khatija Nait M’Barek, Stephan Christgau, Fazool Shipkolye, Florina Moldovan |
Arthritis & Rheumatism | 2003 |
|
Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis
HW Walling, LJ Raggatt, DW Irvine, OY Barmina, JE Toledano, MB Goldring, KA Hruska, HD Adkisson, RE Burdge, CJ Gatt, DA Harwood, NC Partridge |
Osteoarthritis and Cartilage | 2003 |
|
Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway
RF Loeser, CB Forsyth, AM Samarel, HJ Im |
The Journal of biological chemistry | 2003 |
|
Genomics of osteoarthritis
T Aigner, J Dudhia |
Current Opinion in Rheumatology | 2003 |
|
Human Adult Chondrocytes Express Hepatocyte Growth Factor (HGF) Isoforms but Not HGF: Potential Implication of Osteoblasts on the Presence of HGF in Cartilage
M Guévremont, J Martel-Pelletier, F Massicotte, G Tardif, JP Pelletier, P Ranger, D Lajeunesse, P Reboul |
Journal of Bone and Mineral Research | 2003 |
|
Comparison of Mouse Matrix Metalloproteinase 13 Expression in Free-Electron Laser and Scalpel Incisions During Wound Healing
N Wu, ED Jansen, JM Davidson |
Journal of Investigative Dermatology | 2003 |
|
Pathophysiological roles for IL-18 in inflammatory arthritis
K Matsui, H Tsutsui, K Nakanishi |
Expert Opinion on Therapeutic Targets | 2003 |
|
The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis
LS Lohmander, LM Atley, TA Pietka, DR Eyre |
Arthritis & Rheumatism | 2003 |
|
The 12th International Rheumatology Symposium in Tokyo: April 24–26, 2003, Tokyo, Japan
S Kano |
Modern Rheumatology | 2003 |
|
Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites
G Tardif, M Dupuis, P Reboul, C S Geng, J-P Pelletier, P Ranger, J Martel-Pelletier |
Osteoarthritis and Cartilage | 2003 |
|
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: Interaction with exogenous cytokines
P Patwari, MN Cook, MA DiMicco, SM Blake, IE James, S Kumar, AA Cole, MW Lark, AJ Grodzinsky |
Arthritis & Rheumatism | 2003 |
|
Reversible Metaphyseal Dysplasia, a Novel Bone Phenotype, in Two Unrelated Children with Autoimmunepolyendocrinopathy-Candidiasis-Ectodermal Dystrophy: Clinical and Molecular Studies
M Harris, O Kecha, C Deal, CR Howlett, D Deiss, V Tobias, J Simoneau-Roy, J Walker |
The Journal of clinical endocrinology and metabolism | 2003 |
|
Real-time visualization of MMP-13 promoter activity in transgenic mice
N Wu, S Opalenik, J Liu, ED Jansen, MG Giro, JM Davidson |
Matrix Biology | 2002 |
|
Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes
CB Forsyth, J Pulai, RF Loeser |
Arthritis & Rheumatism | 2002 |
|
Osteoarthritis II: Pathology and pathogenesis
WW Buchanan, WF Kean |
InflammoPharmacology | 2002 |
|
Articular cartilage calcification and matrix vesicles
DS Howell |
Current Rheumatology Reports | 2002 |
|
The inhibition of metalloproteinases to treat osteoarthritis: reality and new perspectives
Y Henrotin, C Sanchez, JY Reginster |
Expert Opinion on Therapeutic Patents | 2002 |
|
Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-κB) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
A Liacini, J Sylvester, WQ Li, M Zafarullah |
Matrix Biology | 2002 |
|
Phosphodiesterase isoenzyme families in human osteoarthritis chondrocytes - functional importance of phosphodiesterase 4
H Tenor, E Hedbom, HJ Häuselmann, C Schudt, A Hatzelmann |
British Journal of Pharmacology | 2002 |
|
A Novel Negative Regulatory Element in the Human Collagenase-3 Proximal Promoter Region
M Benderdour, G Tardif, JP Pelletier, M Dupuis, C Geng, J Martel-Pelletier |
Biochemical and Biophysical Research Communications | 2002 |
|
Parathyroid hormone-dependent signaling pathways regulating genes in bone cells
JT Swarthout, RC D'Alonzo, N Selvamurugan, NC Partridge |
Gene | 2002 |
|
The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoter
SE Campbell, A Sood, DJ Argyle, L Nasir, SA Argyle, D Bennett |
Gene | 2002 |
|
Abdominal Aortic Aneurysms: Basic Mechanisms and Clinical Implications
RW Thompson, PJ Geraghty, JK Lee |
Current Problems in Surgery | 2002 |
|
Tissue inhibitor of metalloproteinases-4 (TIMP-4) gene expression is increased in human osteoarthritic femoral head cartilage
W Huang, WQ Li, F Dehnade, M Zafarullah |
Journal of Cellular Biochemistry | 2002 |
|
Dilinoleoylphosphatidylcholine prevents transforming growth factor-β1-mediated collagen accumulation in cultured rat hepatic stellate cells
Q Cao, KM Mak, CS Lieber |
Journal of Laboratory and Clinical Medicine | 2002 |
|
Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR/ort model of osteoarthritis and in collagen-induced arthritis
JS Price, MG Chambers, AR Poole, A Fradin, RM Mason |
Osteoarthritis and Cartilage | 2002 |
|
Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis
J Flannelly, MG Chambers, J Dudhia, RM Hembry, G Murphy, RM Mason, MT Bayliss |
Osteoarthritis and Cartilage | 2002 |
|
A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis
J L Huebner, M A Hanes, B Beekman, J M TeKoppele, V B Kraus |
Osteoarthritis and Cartilage | 2002 |
|
Regulation of Collagenase-3 and Osteocalcin Gene Expression by Collagen and Osteopontin in Differentiating MC3T3-E1 Cells
RC D'Alonzo, AJ Kowalski, DT Denhardt, GA Nickols, NC Partridge |
The Journal of biological chemistry | 2002 |
|
A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1?mediated pathway
T Yasuda, AR Poole |
Arthritis & Rheumatism | 2002 |
|
Expression of matrix metalloproteinases in articular cartilage of temporomandibular and knee joints of mice during growth, maturation, and aging
A Gepstein, S Shapiro, G Arbel, N Lahat, E Livne |
Arthritis & Rheumatism | 2002 |
|
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro
B Bau, PM Gebhard, J Haag, T Knorr, E Bartnik, T Aigner |
Arthritis & Rheumatism | 2002 |
|
Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: Involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade
P Reboul, JP Pelletier, G Tardif, M Benderdour, P Ranger, DP Bottaro, J Martel-Pelletier |
Arthritis & Rheumatism | 2001 |
|
Role of interleukin-1 in induction of matrix metalloproteinases synthesized by rat temporomandibular joint chondrocytes and disc cells
Y Ijima, M Kobayashi, E Kubota |
European Journal of Oral Sciences | 2001 |
|
Synovial fluid gelatinase concentrations and matrix metalloproteinase and cytokine expression in naturally occurring joint disease in horses
TN Trumble, GW Trotter, JR Oxford, CW McIlwraith, S Cammarata, JL Goodnight, RC Billinghurst, DD Frisbie |
American Journal of Veterinary Research | 2001 |
|
Peroxisome proliferator-activated receptor ? activators inhibit interleukin-1?-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes
H Fahmi, JA di Battista, JP Pelletier, F Mineau, P Ranger, J Martel-Pelletier |
Arthritis & Rheumatism | 2001 |
|
A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines
KS Mix, JA Mengshol, U Benbow, MP Vincenti, MB Sporn, CE Brinckerhoff |
Arthritis & Rheumatism | 2001 |
|
Induction of Matrix Metalloproteinase-8 in Human Fibroblasts by Basic Calcium Phosphate and Calcium Pyrophosphate Dihydrate Crystals: Effect of Phosphocitrate
PM Reuben, L Wenger, M Cruz, HS Cheung |
Connective Tissue Research | 2001 |
|
The Novartis-ILAR Rheumatology Prize 2001 Osteoarthritis: from molecule to man
JP Pelletier, J Martel-Pelletier |
Arthritis research | 2001 |
|
Basic calcium phosphate crystals activate human osteoarthritic synovial fibroblasts and induce matrix metalloproteinase-13 (collagenase-3) in adult porcine articular chondrocytes
GM McCarthy, PR Westfall, I Masuda, PA Christopherson, HS Cheung, PG Mitchell |
Annals of the rheumatic diseases | 2001 |
|
Tissue inhibitor of metalloprotease-1 (TIMP-1) serum level may predict progression of hip osteoarthritis
X Chevalier, T Conrozier, M Gehrmann, P Claudepierre, P Mathieu, S Unger, E Vignon |
Osteoarthritis and Cartilage | 2001 |
|
Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes
T Tamura, N Kosaka, J Ishiwa, T Sato, H Nagase, A Ito |
Osteoarthritis and Cartilage | 2001 |
|
Basic calcium phosphate crystals up-regulate metalloproteinases but down-regulate tissue inhibitor of metalloproteinase-1 and -2 in human fibroblasts
G Bai, DS Howell, GA Howard, BA Roos, HS Cheung |
Osteoarthritis and Cartilage | 2001 |
|
Expression of vitamin D receptors and matrix metalloproteinases in osteoarthritic cartilage and human articular chondrocytes in vitro
LC Tetlow, DE Woolley |
Osteoarthritis and Cartilage | 2001 |
|
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells: Collagenase-3 in Cell Invasion
R Ala-aho, N Johansson, AH Baker, VM Kähäri |
International Journal of Cancer | 2001 |
|
Immunolocalization of Matrix Metalloproteinases in Partial-Thickness Defects in Pig Articular Cartilage: A Preliminary Report
RM Hembry, J Dyce, I Driesang, EB Hunziker, AJ Fosang, JA Tyler, G Murphy |
The Journal of Bone and Joint Surgery. American volume. | 2001 |
|
Tripterygium wilfordii Hook F Extract Suppresses Proinflammatory Cytokine-Induced Expression of Matrix Metalloproteinase Genes in Articular Chondrocytes by Inhibiting Activating Protein-1 and Nuclear Factor-κB Activities
J Sylvester, A Liacini, WQ Li, F Dehnade, M Zafarullah |
Molecular pharmacology | 2001 |
|
Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro
M Balduyck, F Zerimech, V Gouyer, R Lemaire, B Hemon, G Grard, C Thiebaut, V Lemaire, E Dacquembronne, T Duhem, A Lebrun, M J Dejonghe, G Huet |
Clinical & Experimental Metastasis | 2001 |
|
Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1β
JR Robbins, B Thomas, L Tan, B Choy, JL Arbiser, F Berenbaum, MB Goldring |
Arthritis & Rheumatism | 2000 |
|
Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis
BV Shlopov, ML Gumanovskaya, KA Hasty |
Arthritis & Rheumatism | 2000 |
|
Matrix metalloproteinase-13 expression in rabbit knee joint connective tissues: influence of maturation and response to injury
MP le Graverand, J Eggerer, P Sciore, C Reno, E Vignon, I Otterness, DA Hart |
Matrix Biology | 2000 |
|
MMP-13 is induced during chondrocyte hypertrophy
M D'Angelo, Z Yan, M Nooreyazdan, M Pacifici, DS Sarment, PC Billings, PS Leboy |
Journal of Cellular Biochemistry | 2000 |
|
Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown
WD Shingleton, AJ Ellis, AD Rowan, TE Cawston |
Journal of Cellular Biochemistry | 2000 |
|
Effects of interleukin-1β and tumor necrosis factor-α on expression of matrix-related genes by cultured equine articular chondrocytes
DW Richardson, GR Dodge |
American Journal of Veterinary Research | 2000 |
|
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis
Y Yoshihara, H Nakamura, K Obata, H Yamada, T Hayakawa, K Fujikawa, Y Okada |
Annals of the rheumatic diseases | 2000 |
|
Protein production by osteoblasts: modulation by breast cancer cell-derived factors
M Lacroix, PJ Marie, JJ Body |
Breast Cancer Research and Treatment | 2000 |
|
Matrix Metalloproteinases And Aggrecanase
S Roberts, B Caterson, J Menage, EH Evans, DC Jaffray, SM Eisenstein |
Spine | 2000 |
|
Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha
S Murakami, V Lefebvre, B Crombrugghe |
The Journal of biological chemistry | 2000 |
|
An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies
LA Neuhold, L Killar, W Zhao, ML Sung, L Warner, J Kulik, J Turner, W Wu, C Billinghurst, T Meijers, AR Poole, P Babij, LJ DeGennaro |
Clinica Chimica Acta | 2000 |
|
Matrix-degrading metalloproteinases and their roles in joint destruction
Y Okada |
Modern Rheumatology | 2000 |
|
Cartilage damage after intraarticular exposure to collagenase 3
IG Otterness, ML Bliven, JD Eskra, JM Koppele, HA Stukenbrok, AJ Milici |
Osteoarthritis and Cartilage | 2000 |
|
Diacerhein and rhein reduce the ICE-induced IL-1β and IL-18 activation in human osteoarthritic cartilage
F Moldovan, J Pelletier, FC Jolicoeur, JM Cloutier, J Martel-Pelletier |
Osteoarthritis and Cartilage | 2000 |
|
Developmental Regulation of Collagenase-3 mRNA in Normal, Differentiating Osteoblasts through the Activator Protein-1 and the runt Domain Binding Sites
SK Winchester, N Selvamurugan, RC D'Alonzo, NC Partridge |
The Journal of biological chemistry | 2000 |
|
Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1
R Ala-aho, N Johansson, R Grénman, NE Fusenig, C López-Otín, VM Kähäri |
Oncogene | 2000 |
|
Substrate Specificity of Human Collagenase 3 Assessed Using a Phage-displayed Peptide Library
SJ Deng, DM Bickett, JL Mitchell, MH Lambert, RK Blackburn, HL Carter, J Neugebauer, G Pahel, MP Weiner, ML Moss |
The Journal of biological chemistry | 2000 |
|
Wild Type and Mutant p53 Differentially Regulate the Gene Expression of Human Collagenase-3 ( hMMP-13 )
Y Sun, JM Cheung, J Martel-Pelletier, JP Pelletier, L Wenger, RD Altman, DS Howell, HS Cheung |
The Journal of biological chemistry | 2000 |
|
Gelenkpathologie
W Mohr |
2000 | |
|
Peritoneal Surgery
GS diZerega |
2000 | |
|
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase
N Johansson, R Ala-aho, V Uitto, R Grenman, NE Fusenig, C Lopez-Otin, VM Kahari |
Journal of cell science | 2000 |
|
Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate
YT Konttinen, T Salo, R Hanemaaijer, H Valleala, T Sorsa, M Sutinen, A Čeponis, JW Xu, S Santavirta, O Teronen, C López-Otı́n |
Matrix Biology | 1999 |
|
Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes
CR Flannery, CB Little, B Caterson, CE Hughes |
Matrix Biology | 1999 |
|
Role of Matrix Metalloproteinases and Their Inhibition in Cutaneous Wound Healing and Allergic Contact Hypersensitivity
BK Pilcher, M Wang, XJ Qin, WC Parks, R M., HG Welgus |
Annals of the New York Academy of Sciences | 1999 |
|
Collagenase-3 (MMP-13) is Expressed by Tumor Cells in Invasive Vulvar Squamous Cell Carcinomas
N Johansson, M Vaalamo, S Grénman, S Hietanen, P Klemi, U Saarialho-Kere, VM Kähäri |
The American Journal of Pathology | 1999 |
|
In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage
AJ Freemont, RJ Byers, YO Taiwo, JA Hoyland |
Annals of the rheumatic diseases | 1999 |
|
Expression of Collagenase-3 (MMP-13) in Human Abdominal Aortic Aneurysms and Vascular Smooth Muscle Cells in Culture
D Mao, JK Lee, SJ VanVickle, RW Thompson |
Biochemical and Biophysical Research Communications | 1999 |
|
Expression of matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 in acute liver injury
Y Yata, T Takahara, K Furui, LP Zhang, A Watanabe |
Journal of Hepatology | 1999 |
|
Structure of recombinant mouse collagenase-3 (MMP-13)
I Botos, E Meyer, SM Swanson, V Lemaı̂tre, Y Eeckhout, EF Meyer |
Journal of Molecular Biology | 1999 |
|
Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase
FA Mercuri, KJ Doege, EC Arner, MA Pratta, K Last, AJ Fosang |
The Journal of biological chemistry | 1999 |
|
Articular collagen degradation in the Hulth-Telhag model of osteoarthritis
JN Rogart, HJ Barrach, CO Chichester |
Osteoarthritis and Cartilage | 1999 |
|
Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors
M Balbín, A M Pendás, J A Uría, M G Jiménez, J P Freije, C López-Otín |
APMIS | 1999 |
|
Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody
IG Otterness, JT Downs, C Lane, ML Bliven, H Stukenbrok, DN Scampoli, AJ Milici, PS Mézes |
Clinica Chimica Acta | 1999 |
|
Collagenase 3 production by human osteoarthritic chondrocytes in response to growth factors and cytokines is a function of the physiologic state of the cells
G Tardif, JP Pelletier, M Dupuis, C Geng, JM Cloutier, J Martel-Pelletier |
Arthritis & Rheumatism | 1999 |
|
Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures
JS Price, S Wang-Weigand, R Bohne, LD Kozaci, AP Hollander |
Arthritis & Rheumatism | 1999 |
|
Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase
L Ravanti, J Heino, C López-Otı́n, VM Kähäri |
The Journal of biological chemistry | 1999 |
|
Mitogen-activated protein kinase and nuclear factor ?B together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: Possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAPKAPK)
J Martel-Pelletier, F Mineau, D Jovanovic, JA di Battista, JP Pelletier |
Arthritis & Rheumatism | 1999 |
|
Transforming Growth Factor-β Induces Collagenase-3 Expression by Human Gingival Fibroblasts via p38 Mitogen-activated Protein Kinase
L Ravanti, L Häkkinen, H Larjava, U Saarialho-Kere, M Foschi, J Han, VM Kähäri |
The Journal of biological chemistry | 1999 |
|
Advances in Osteoarthritis
S Tanaka, C Hamanishi |
1999 | |
|
Collagenase 3 Is a Target of Cbfa1, a Transcription Factor of the runt Gene Family Involved in Bone Formation
MJ Jiménez, M Balbín, JM López, J Alvarez, T Komori, C López-Otín |
Molecular and cellular biology | 1999 |
|
Matrix Metalloproteinases: The Clue to Intervertebral Disc Degeneration?
P Goupille, MI Jayson, JP Valat, AJ Freemont |
Spine | 1998 |
|
Pharmacological effect of tetracyclines on proteoglycanases from interleukin-1 -treated articular cartilage
J Steinmeyer |
Biochemical Pharmacology | 1998 |
|
Collagenase-3 (MMP-13) Expression in Chondrosarcoma Cells and Its Regulation by Basic Fibroblast Growth Factor
JA Uría, M Balbín, JM López, J Alvarez, F Vizoso, M Takigawa, C López-Otín |
The American Journal of Pathology | 1998 |
|
In Vitro Sensitivity of the Three Mammalian Collagenases to Tetracycline Inhibition: Relationship to Bone and Cartilage Degradation
RA Greenwald, LM Golub, NS Ramamurthy, M Chowdhury, SA Moak, T Sorsa |
Bone | 1998 |
|
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx
M Cazorla, L Hernández, A Nadal, M Balbín, JM López, F Vizoso, PL Fernández, K Iwata, A Cardesa, C López-Otín, E Campo |
The Journal of Pathology | 1998 |
|
Characterization of helical cleavages in type II collagen generated by matrixins
M Vankemmelbeke, PM Dekeyser, AP Hollander, DJ Buttle, J Demeester |
Biochemical Journal | 1998 |
|
Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3
S Cowell, V Knäuper, ML Stewart, MP D'Ortho, H Stanton, RM Hembry, C López-Otín, JJ Reynolds, G Murphy |
Biochemical Journal | 1998 |
|
Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation
VJ Uitto, K Airola, M Vaalamo, N Johansson, EE Putnins, JD Firth, J Salonen, C López-Otín, U Saarialho-Kere, VM Kähäri |
The American Journal of Pathology | 1998 |
|
Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1)
MP Vincenti, CI Coon, JA Mengshol, S Yocum, P Mitchell, CE Brinckerhoff |
Biochemical Journal | 1998 |
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A Matrix Metalloproteinase Proenzyme Activator Produced by Articular Cartilage
CA Towle, M Wright, AC Hecht, SJ Kuong, LE Papanicolas, R Totkovic, HJ Mankin, BV Treadwell |
Biochemical and Biophysical Research Communications | 1998 |
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The Expression, Refolding, and Purification of the Catalytic Domain of Human Collagenase-3 (MMP-13)
N Pathak, SI Hu, JA Koehn |
Protein Expression and Purification | 1998 |
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Differential Effects of Transforming Growth Factor-β on the Expression of Collagenase-1 and Collagenase-3 in Human Fibroblasts
JA Urı́a, MG Jiménez, M Balbı́n, JM Freije, C López-Otı́n |
The Journal of biological chemistry | 1998 |
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Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown
LD Kozaci, CJ Brown, C Adcocks, A Galloway, AP Hollander, DJ Buttle |
Molecular Pathology | 1998 |
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Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage
RC Billinghurst, L Dahlberg, M Ionescu, A Reiner, R Bourne, C Rorabeck, P Mitchell, J Hambor, O Diekmann, H Tschesche, J Chen, HV Wart, AR Poole |
Journal of Clinical Investigation | 1997 |
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Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ. In vitro mimicking effect by transforming growth factor β
F Moldovan, JP Pelletier, J Hambor, JM Cloutier, J Martel-Pelletier |
Arthritis & Rheumatism | 1997 |
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Mechanisms of connective tissue matrix destruction in periodontitis
JJ Reynolds, MC Meikle |
Periodontology 2000 | 1997 |
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Effects of tenidap on the progression of osteoarthritic lesions in a canine experimental model. Suppression of metalloprotease and interleukin-1 activity
JC Fernandes, JP Caron, J Martel-Pelletier, D Jovanovic, F Mineau, G Tardif, IG Otterness, JP Pelletier |
Arthritis & Rheumatism | 1997 |
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Matrix metalloproteinases in skin
VM Kahari, U Saarialho-Kere |
Experimental Dermatology | 1997 |
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Distinct Populations of Stromal Cells Express Collagenase-3 (MMP-13) and Collagenase-1 (MMP-1) in Chronic Ulcers but Not in Normally Healing Wounds
M Vaalamo, L Mattila, N Johansson, AL Kariniemi, ML Karjalainen-Lindsberg, VM Kahari, U Saarialho-Kere |
Journal of Investigative Dermatology | 1997 |
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Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development
N Johansson, U Saarialho-Kere, K Airola, R Herva, L Nissinen, J Westermarck, E Vuorio, J Heino, VM Kähäri |
Developmental Dynamics | 1997 |
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Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1β (IL-1β) in human fibroblasts and BC-8701 breast cancer cells
JL Rutter, U Benbow, CI Coon, CE Brinckerhoff |
Journal of Cellular Biochemistry | 1997 |
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Structural Analysis and Promoter Characterization of the Human Collagenase-3 Gene (MMP13)
AM Pendás, M Balbı́n, E Llano, MG Jiménez, C López-Otı́n |
Genomics | 1997 |
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The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix
BK Pilcher, JA Dumin, BD Sudbeck, SM Krane, HG Welgus, WC Parks |
The Journal of Cell Biology | 1997 |
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Expression of membrane-type 1 matrix metalloproteinase and activation of progelatinase A in human osteoarthritic cartilage
K Imai, S Ohta, T Matsumoto, N Fujimoto, H Sato, M Seiki, Y Okada |
The American Journal of Pathology | 1997 |
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Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific
AJ Freemont, V Hampson, R Tilman, P Goupille, Y Taiwo, JA Hoyland |
Annals of the rheumatic diseases | 1997 |
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Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck
N Johansson, K Airola, R Grénman, AL Kariniemi, U Saarialho-Kere, VM Kähäri |
The American Journal of Pathology | 1997 |
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Cloning, sequencing and characterization of the 5'-flanking region of the human collagenase-3 gene
G Tardif, JP Pelletier, M Dupuis, JE Hambor, J Martel-Pelletier |
Biochemical Journal | 1997 |
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Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA
S Matsumoto, M Katoh, S Saito, T Watanabe, Y Masuho |
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 1997 |
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Transcriptional Induction of Collagenase-1 in Differentiated Monocyte-like (U937) Cells is Regulated by AP-1 and an Upstream C/EBP-β Site
GA Doyle, RA Pierce, WC Parks |
The Journal of biological chemistry | 1997 |
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Cell Type-specific Inhibition of Keratinocyte Collagenase-1 Expression by Basic Fibroblast Growth Factor and Keratinocyte Growth Factor: A COMMON RECEPTOR PATHWAY
BK Pilcher, J Gaither-Ganim, WC Parks, HG Welgus |
The Journal of biological chemistry | 1997 |
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Collagenase: a key enzyme in collagen turnover
WD Shingleton, TE Cawston, DJ Hodges, P Brick |
Biochemistry and Cell Biology | 1996 |
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Nuclear hormone receptors inhibit matrix metalloproteinase (MMP) gene expression through diverse mechanisms
D J Schroen, C E Brinckerhoff |
Gene expression | 1996 |
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Osteopontin: a protein with diverse functions
O Lindy, YT Konttinen, T Sorsa, Y Ding, S Santavirta, A Ceponis, C López-Otín |
The FASEB Journal | 1993 |
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