Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Recent advances in gene mutagenesis by site-directed recombination.
J D Marth
J D Marth
Published May 1, 1996
Citation Information: J Clin Invest. 1996;97(9):1999-2002. https://doi.org/10.1172/JCI118634.
View: Text | PDF
Perspective Article has an altmetric score of 6

Recent advances in gene mutagenesis by site-directed recombination.

  • Text
  • PDF
Abstract

Authors

J D Marth

×

Total citations by year

Year: 2019 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 2 1 1 1 3 1 4 2 4 3 2 4 3 6 5 11 11 7 11 4 2 88
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (88)

Title and authors Publication Year
Generating mouse models for biomedical research: technological advances
CB Gurumurthy, KC Lloyd
Disease models & mechanisms 2019
Encyclopedia of Animal Cognition and Behavior
J Vonk, T Shackelford
Encyclopedia of Animal Cognition and Behavior 2019
Biological roles of glycans
A Varki
Glycobiology 2016
An Essential Role for the K + -dependent Na + /Ca 2+ -exchanger, NCKX4, in Melanocortin-4-receptor-dependent Satiety
XF Li, J Lytton
The Journal of biological chemistry 2014
Brenner's Encyclopedia of Genetics
B Joe, JP Rapp
Brenner's Encyclopedia of Genetics 2013
Peroxisome Proliferator-Activated Receptors (PPARs)
MZ Badr, JA Youssef
Peroxisome Proliferator-Activated Receptors (PPARs) 2012
Peroxisome Proliferator-Activated Receptors (PPARs)
MZ Badr, JA Youssef
Peroxisome Proliferator-Activated Receptors (PPARs) 2012
Peroxisome Proliferator-Activated Receptors (PPARs)
MZ Badr, JA Youssef
Peroxisome Proliferator-Activated Receptors (PPARs) 2012
Encyclopedia of Life Sciences
B Dahlbäck
Encyclopedia of Life Sciences 2011
Analysis of conditional gene deletion using probe based Real-Time PCR
B Weis, J Schmidt, F Lyko, HG Linhart
BMC Biotechnology 2010
Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation
SY Lee, M Miller, JY Cho, DJ Song, M Karin, DH Broide
International Immunopharmacology 2010
The Hypothalamus and  -Cell Connection in the Gene-Targeting Era
MW Schwartz, SJ Guyenet, V Cirulli
Diabetes 2010
National Institute of Allergy and Infectious Diseases, NIH
VS Georgiev
2010
Basic and Clinical Dermatology
N Muizzuddin, D Maes, P Giacomoni
Skin Moisturization 2009
Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice
CM Bäckman, YJ Zhang, N Malik, L Shan, BJ Hoffer, H Westphal, AC Tomac
Journal of Neuroscience Methods 2009
Bone is the physiologically relevant site of the PHEX/Phex mutation in X-linked hypophosphatemia
Baozhi Yuan, Masanori Takaiwa, Thomas L. Clemens, Jian Q. Feng, Rajiv Kumar, Peter S. N. Rowe, Yixia Xie, and Marc K. Drezner
Journal of Clinical Investigation 2008
Genetic approaches for changing the heart and dissecting complex syndromes
MA Moga, T Nakamura, J Robbins
Journal of Molecular and Cellular Cardiology 2008
Mouse models of oxidative phosphorylation dysfunction and disease
UD Vempati, A Torraco, CT Moraes
Methods 2008
The expanding role of mouse genetics for understanding human biology and disease
D Nguyen, T Xu
Disease models & mechanisms 2008
Polysialic Acid-Directed Migration and Differentiation of Neural Precursors Are Essential for Mouse Brain Development
K Angata, V Huckaby, B Ranscht, A Terskikh, JD Marth, M Fukuda
Molecular and cellular biology 2007
Cre Recombinase Gene Transfer In Vitro and Detection of loxP -Dependent Recombination: Figure 1
K Ohtsubo, JD Marth
Cold Spring Harbor Protocols 2007
Conditional Mutagenesis of the Genome Using Site-Specific DNA Recombination: Figure 1
K Ohtsubo, JD Marth
Cold Spring Harbor Protocols 2007
Unusual N -Glycan Structures in α-Mannosidase II/IIx Double Null Embryos Identified by a Systematic Glycomics Approach Based on Two-dimensional LC Mapping and Matrix-dependent Selective Fragmentation Method in MALDI-TOF/TOF Mass Spectrometry
M Hato, H Nakagawa, M Kurogochi, TO Akama, JD Marth, MN Fukuda, SI Nishimura
Molecular & cellular proteomics : MCP 2006
Importance of K + -dependent Na + /Ca 2+ -exchanger 2, NCKX2, in Motor Learning and Memory
XF Li, L Kiedrowski, F Tremblay, FR Fernandez, M Perizzolo, RJ Winkfein, RW Turner, JS Bains, DE Rancourt, J Lytton
The Journal of biological chemistry 2006
Targeted ablation of the chromogranin A gene: Elevated blood pressure rescued by the human ortholog
Nitish R. Mahapatra, Daniel T. O’Connor, Sucheta M. Vaingankar, Amiya P. Sinha Hikim, Manjula Mahata, Saugata Ray, Eugenie Staite, Hongjiang Wu, Yusu Gu, Nancy Dalton, Brian P. Kennedy, Michael G. Ziegler, John Ross Jr., Sushil K. Mahata
Journal of Clinical Investigation 2005
Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle
H García-Rivello, J Taranda, M Said, P Cabeza-Meckert, M Vila-Petroff, J Scaglione, S Ghio, J Chen, C Lai, RP Laguens, KC Lloyd, CM Hertig
American journal of physiology. Heart and circulatory physiology 2005
Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium
DH Broide, T Lawrence, T Doherty, JY Cho, M Miller, K McElwain, S McElwain, M Karin
Proceedings of the National Academy of Sciences 2005
DARPP-32 genomic fragments drive Cre expression in postnatal striatum
AI Bogush, LE McCarthy, C Tian, V Olm, T Gieringer, S Ivkovic, ME Ehrlich
genesis 2005
Generation of a Mouse Expressing a Conditional Knockout of the Hepatocyte Growth Factor Gene: Demonstration of Impaired Liver Regeneration
D Phaneuf, AD Moscioni, C Leclair, SE Raper, JM Wilson
DNA and Cell Biology 2004
Sialyltransferase ST8Sia-II Assembles a Subset of Polysialic Acid That Directs Hippocampal Axonal Targeting and Promotes Fear Behavior
K Angata, JM Long, O Bukalo, W Lee, A Dityatev, A Wynshaw-Boris, M Schachner, M Fukuda, JD Marth
The Journal of biological chemistry 2004
Ogt-Dependent X-Chromosome-Linked Protein Glycosylation Is a Requisite Modification in Somatic Cell Function and Embryo Viability
N O'Donnell, NE Zachara, GW Hart, JD Marth
Molecular and cellular biology 2004
A GENETICAPPROACHTOMAMMALIANGLYCANFUNCTION
JB Lowe, JD Marth
Annual Review of Biochemistry 2003
FUNCTIONALGENOMICS AND THECOMPARATIVEPHYSIOLOGY OFHYPOXIA
FL Powell
Annual Review of Physiology 2003
Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis
S Tomatsu, KO Orii, RE Fleming, CC Holden, A Waheed, RS Britton, MA Gutierrez, S Velez-Castrillon, BR Bacon, WS Sly
Proceedings of the National Academy of Sciences 2003
Dopaminergic mechanisms of neural plasticity in respiratory control: transgenic approaches
KA Huey, JM Szewczak, FL Powell
Respiratory Physiology & Neurobiology 2003
A G ENETIC A PPROACHTO M AMMALIAN G LYCAN F UNCTION
JB Lowe, JD Marth
Annual Review of Biochemistry 2003
Functional genomic dissection of multimeric protein families in zebrafish
KC Cheng, R Levenson, JD Robishaw
Developmental Dynamics 2003
Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure
SY Shai, AE Harpf, CJ Babbitt, MC Jordan, MC Fishbein, J Chen, M Omura, TA Leil, KD Becker, M Jiang, DJ Smith, SR Cherry, JC Loftus, RS Ross
Circulation research 2002
Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis
Y Wang, J Tan, M Sutton-Smith, D Ditto, M Panico, RM Campbell, NM Varki, JM Long, J Jaeken, SR Levinson, A Wynshaw-Boris, HR Morris, D Le, A Dell, H Schachter, JD Marth
Glycobiology 2002
A cre recombinase transgene with mosaic, widespread tamoxifen-inducible action
C Guo, W Yang, CG Lobe
genesis 2002
Missense models [Gustm(E536A)Sly, Gustm(E536Q)Sly, and Gustm(L175F)Sly] of murine mucopolysaccharidosis type VII produced by targeted mutagenesis
S Tomatsu, KO Orii, C Vogler, JH Grubb, EM Snella, MA Gutierrez, T Dieter, K Sukegawa, T Orii, N Kondo, WS Sly
Proceedings of the National Academy of Sciences 2002
Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P 2 /LP B2 /EDG-5 and S1P 3 /LP B3 /EDG-3
I Ishii, X Ye, B Friedman, S Kawamura, JJ Contos, MA Kingsbury, AH Yang, G Zhang, JH Brown, J Chun
The Journal of biological chemistry 2002
Congenital Disorders of Glycosylation: Glycosylation Defects in Man and Biological Models for Their Study
T Marquardt, H Freeze
Biological Chemistry 2001
SC35 Plays a Role in T Cell Development and Alternative Splicing of CD45
HY Wang, X Xu, JH Ding, JR Bermingham, XD Fu
Molecular Cell 2001
Site- and Time-Specific Gene Targeting in the Mouse
D Metzger, P Chambon
Methods 2001
Approaches to define the role of SF-1 at different levels of the hypothalamic-pituitary-steroidogenic organ axis
M Bakke, L Zhao, KL Parker
Molecular and Cellular Endocrinology 2001
Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice
Y Liao, KH Day, DN Damon, BR Duling
Proceedings of the National Academy of Sciences 2001
Encyclopedia of Genetics
B Sauer
Encyclopedia of Genetics 2001
Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LP B3 /EDG-3
I Ishii, B Friedman, X Ye, S Kawamura, C McGiffert, JJ Contos, MA Kingsbury, G Zhang, JH Brown, J Chun
The Journal of biological chemistry 2001
Experimental IGF-I Receptor Deficiency Generates a Sexually Dimorphic Pattern of Organ-Specific Growth Deficits in Mice, Affecting Fat Tissue in Particular
M Holzenberger, G Hamard, R Zaoui, P Leneuve, B Ducos, C Beccavin, L Périn, YL Bouc
Endocrinology 2001
Pharmacology of GABA and Glycine Neurotransmission
H Möhler
2001
Genetic dissection of nodal function in patterning the mouse embryo
LA Lowe, S Yamada, MR Kuehn
Development (Cambridge, England) 2001
Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function
L Zhao, M Bakke, Y Krimkevich, LJ Cushman, AF Parlow, SA Camper, KL Parker
Development (Cambridge, England) 2001
HoxB6-Cre transgenic mice express Cre recombinase in extra-embryonic mesoderm, in lateral plate and limb mesoderm and at the midbrain/hindbrain junction
LA Lowe, S Yamada, MR Kuehn
genesis 2000
Suppression of Gene Expression by Targeted Disruption of Messenger RNA: Available Options and Current Strategies
KY Jen, AM Gewirtz
Stem Cells 2000
Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior
JJ Contos, N Fukushima, JA Weiner, D Kaushal, J Chun
Proceedings of the National Academy of Sciences 2000
Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene
M Holzenberger, C Lenzner, P Leneuve, R Zaoui, G Hamard, S Vaulont, YL Bouc
Nucleic Acids Research 2000
The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny
R Shafi, SP Iyer, LG Ellies, N O'Donnell, KW Marek, D Chui, GW Hart, JD Marth
Proceedings of the National Academy of Sciences 2000
The Laboratory Rat
H Schulz, H Muhle
The Laboratory Rat 2000
F9 Embryonal Carcinoma Cells Engineered for Tamoxifen-Dependent Cre-Mediated Site-Directed Mutagenesis and Doxycycline-Inducible Gene Expression
H Chiba, P Chambon, D Metzger
Experimental Cell Research 2000
What Can Transgenic and Gene-targeted Mouse Models Teach Us about Salivary Gland Physiology?
JE Melvin, HV Nguyen, RL Evans, GE Shull
Advances in dental research 2000
Transgenic animals in integrative biology: approaches and interpretations of outcome
RS Williams, PD Wagner
Journal of applied physiology 2000
A Targeted Partial Invalidation of the Insulin-Like Growth Factor I Receptor Gene in Mice Causes a Postnatal Growth Deficit*
M Holzenberger, P Leneuve, G Hamard, B Ducos, L Perin, M Binoux, YL Bouc
Endocrinology 2000
A minimal c-fes cassette directs myeloid-specific expression in transgenic mice
A Heydemann, S Warming, C Clendenin, K Sigrist, JP Hjorth, MC Simon
Blood 2000
Genetically engineered mice in drug development
JN Livingston
Journal of Internal Medicine 1999
Demystified ... gene knockouts
JP Iredale
Molecular pathology : MP 1999
A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality
KW Marek, IK Vijay, JD Marth
Glycobiology 1999
GFPcreFusion Vectors with Enhanced Expression
Y Le, JL Miller, B Sauer
Analytical Biochemistry 1999
Gene therapy for chronic myelogenous leukemia
CM Verfaillie, RS McIvor, RC Zhao
Molecular Medicine Today 1999
Acute in vivo Effects of Acth by Exo Utero Microinjection on Differentiation, Steroidogenesis and Proliferation of Fetal Mouse Adrenocytes
H Zhang, T Hatta, L Ma, R Hashimoto, I Kihara, H Otani
Endocrine Research 1999
α-Gal and Anti-Gal
U Galili, JL Avila
1999
TRANSGENIC MICE IN THE ANALYSIS OF METABOLIC REGULATION
F Bosch, A Pujol, A Valera
Annual Review of Nutrition 1998
Cre-loxP-Mediated DNA Flip-Flop in Mammalian Cells Leading to Alternate Expression of Retrovirally Transduced Genes
M Kano, H Igarashi, I Saito, M Masuda
Biochemical and Biophysical Research Communications 1998
The insulin receptor--a critical link in glucose homeostasis and insulin action
ME Patti, CR Kahn
Journal of Basic and Clinical Physiology and Pharmacology 1998
Introduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: a comparison of homologous recombination methods
M Gschwind, G Huber
Molecular and cellular biology 1998
Introduction of Hereditary Disease-Associated Mutations into the β-Amyloid Precursor Protein Gene of Mouse Embryonic Stem Cells: a Comparison of Homologous Recombination Methods
M Gschwind, G Huber
Molecular and cellular biology 1998
Induction of Ectopic Corticotropic Tumor in Mouse Embryos by Exo Utero Cell Transplantation and Its Effects on the Fetal Adrenal Gland
H Zhang, T Hatta, J Udagawa, K Moriyama, R Hashimoto, H Otani
Endocrinology 1998
Protein Glycosylation
RM Bill, L Revers, IB Wilson
1998
Mammary Gland Transgenesis
FO Castro, J Jänne
1998
Nucleic Acid Therapeutics: State of the Art and Future Prospects
AM Gewirtz, DL Sokol, MZ Ratajczak
Blood 1998
Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis
J Chen, SW Kubalak, KR Chien
Development (Cambridge, England) 1998
Gene disruption in mice: models of development and disease
B S Shastry
Molecular and Cellular Biochemistry 1998
Alpha-Mannosidase-II Deficiency Results in Dyserythropoiesis and Unveils an Alternate Pathway in Oligosaccharide Biosynthesis
D Chui, M Oh-Eda, YF Liao, K Panneerselvam, A Lal, KW Marek, HH Freeze, KW Moremen, MN Fukuda, JD Marth
Cell 1997
Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domains
R Feil, J Wagner, D Metzger, P Chambon
Biochemical and Biophysical Research Communications 1997
Generation and analysis of conditional mutant mice
UA Betz
Research in Immunology 1997
Molecular remodeling of cardiac contractile function
J James, J Robbins
American journal of physiology. Heart and circulatory physiology 1997
Genetic manipulation of vascular adhesion molecules in mice
RO Hynes, DD Wagner
Journal of Clinical Investigation 1996
Ligand-activated site-specific recombination in mice
R Feil, J Brocard, B Mascrez, M LeMeur, D Metzger, P Chambon
Proceedings of the National Academy of Sciences 1996

← Previous 1 2 3 4 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 6 patents
Referenced in 1 Wikipedia pages
27 readers on Mendeley
See more details