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Citations to this article

Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections.
M G Netea, … , A F Stalenhoef, J W van der Meer
M G Netea, … , A F Stalenhoef, J W van der Meer
Published March 15, 1996
Citation Information: J Clin Invest. 1996;97(6):1366-1372. https://doi.org/10.1172/JCI118556.
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Research Article Article has an altmetric score of 21

Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections.

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Abstract

Lipoproteins can bind lipopolysaccharide (LPS) and decrease the LPS-stimulated production of pro-inflammatory cytokines. We investigated the effect of increased plasma concentrations of low-density-lipoproteins (LDL) on survival and cytokine production after a lethal challenge with either LPS or live Gram-negative bacteria in LDL receptor deficient mice (LDLR-/-). The LDLR-/- mice challenged with LPS had an eightfold increased LD50 when compared with the wild type controls (C57Bl/6J), while tumor necrosis factor alpha (TNFalpha) and interleukin-1 alpha (IL-1 alpha) plasma concentrations were decreased twofold. LDLR-/- mice had significantly lower and delayed mortality than control mice after infection with Klebsiella pneumoniae. No differences in the outgrowth of bacteria in the organs were present between the two groups, while circulating cytokine concentrations were decreased twofold in LDLR-/- mice. In contrast, the LPS-stimulated in vitro production of cytokines by peritoneal macrophages of LDLR-/- mice was significantly increased compared with controls. This increase was associated with enhanced specific binding of LPS to the macrophages of LDLR-/- mice. In conclusion, endogenous LDL can protect against the lethal effects of endotoxin and Gram-negative infection. At least part of this protection is achieved through decreased in vivo production of pro-inflammatory cytokines, in spite of increased cytokine production capacity.

Authors

M G Netea, P N Demacker, B J Kullberg, O C Boerman, I Verschueren, A F Stalenhoef, J W van der Meer

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 4 3 4 4 5 4 5 1 2 6 3 3 2 4 4 8 4 5 10 6 10 7 10 6 7 11 5 7 4 1 155
Citation information
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Citations to this article in year 2005 (10)

Title and authors Publication Year
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis
G Ferwerda, SE Girardin, BJ Kullberg, LL Bourhis, DJ de Jong, DM Langenberg, R Crevel, GJ Adema, TH Ottenhoff, JW van der Meer, MG Netea
PLoS pathogens 2005
Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis*
JY Chien, JS Jerng, CJ Yu, PC Yang
Critical Care Medicine 2005
High levels of C-reactive protein with low total cholesterol concentrations additively predict all-cause mortality in patients with coronary artery disease
L Janoskuti, Z Forhecz, N Hosszufalusi, M Kleiber, S Walentin, O Balint, J Duba, S Rugonfalvi-Kiss, L Romics, I Karadi, G Fust, Z Prohaszka
European Journal of Clinical Investigation 2005
Low-Density Lipoprotein Cholesterol: Association with Mortality and Hospitalization in Hemodialysis Patients
CK Chiang, TI Ho, SP Hsu, YS Peng, MF Pai, SY Yang, KY Hung, TJ Tsai
Blood Purification 2005
Serum lipids and disease severity in children with severe meningococcal sepsis*
CL Vermont, M Brinker, N K??keci, ED de Kleijn, YB de Rijke, KF Joosten, R Groot, JA Hazelzet
Critical Care Medicine 2005
Effect of recombinant murine granulocyte colony-stimulating factor with or without fluoroquinolone therapy on mixed-infection abscesses in mice
LE Stearne, AG Vonk, BJ Kullberg, IC Gyssens
Antimicrobial agents and chemotherapy 2005
Apolipoproteins modulate the inflammatory response to lipopolysaccharide
JF Berbee, LM Havekes, PC Rensen
Journal of Endotoxin Research 2005
Neuronal, Endocrine, and Anorexic Responses to the T-Cell Superantigen Staphylococcal Enterotoxin A: Dependence on Tumor Necrosis Factor-
A Rossi-George
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Differential Cytokine Production and Toll-Like Receptor Signaling Pathways by Candida albicans Blastoconidia and Hyphae
CA van der Graaf, MG Netea, I Verschueren, JW van der Meer, BJ Kullberg
Infection and immunity 2005
Nucleotide-Binding Oligomerization Domain-2 Modulates Specific TLR Pathways for the Induction of Cytokine Release
MG Netea, G Ferwerda, DJ de Jong, T Jansen, L Jacobs, M Kramer, TH Naber, JP Drenth, SE Girardin, BJ Kullberg, GJ Adema, JW der Meer
Journal of immunology (Baltimore, Md. : 1950) 2005

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