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Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia and severe gram-negative infections.

M G Netea, … , A F Stalenhoef, J W van der Meer

M G Netea, … , A F Stalenhoef, J W van der Meer

Published March 15, 1996
Citation Information: J Clin Invest. 1996;97(6):1366-1372. https://doi.org/10.1172/JCI118556.

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More than Inflammation: Interleukin-1β Polymorphisms and the Lipid Metabolism MG Netea, CA Dinarello	The Journal of clinical endocrinology and metabolism	2011
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Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors L Li, PA Thompson, RL Kitchens	Journal of lipid research	2008
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Immune Recognition ofCandida albicansβ‐glucan by Dectin‐1 NA Gow, MG Netea, CA Munro, G Ferwerda, S Bates, HM Mora-Montes, L Walker, T Jansen, L Jacobs, V Tsoni, GD Brown, FC Odds, JW van der Meer, AJ Brown, BJ Kullberg	The Journal of Infectious Diseases	2007
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Mechanical Ventilation in Healthy Mice Induces Reversible Pulmonary and Systemic Cytokine Elevation with Preserved Alveolar Integrity M Vaneker, FJ Halbertsma, J Egmond, MG Netea, HB Dijkman, DG Snijdelaar, LA Joosten, JG van der Hoeven, GJ Scheffer	Anesthesiology	2007
Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: Amino acid substitutions in the core region and low-density lipoprotein cholesterol levels N Akuta, F Suzuki, Y Kawamura, H Yatsuji, H Sezaki, Y Suzuki, T Hosaka, M Kobayashi, M Kobayashi, Y Arase, K Ikeda, H Kumada	Journal of Hepatology	2007
Mechanical Ventilation in Healthy Mice Induces Reversible Pulmonary and Systemic Cytokine Elevation with Preserved Alveolar Integrity: An In Vivo Model Using Clinical Relevant Ventilation Settings M Vaneker, FJ Halbertsma, J Egmond, MG Netea, HB Dijkman, DG Snijdelaar, LA Joosten, JG van der Hoeven, GJ Scheffer	Anesthesiology	2007
Increased voluntary exercise in mice deficient for tumour necrosis factor-alpha and lymphotoxin-alpha MG Netea, BJ Kullberg, AG Vonk, I Verschueren, LA Joosten, JW van der Meer	European Journal of Clinical Investigation	2007
The role of TNF-α in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk C Popa, MG Netea, PL van Riel, JW van der Meer, AF Stalenhoef	Journal of lipid research	2007
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Immune sensing of Candida albicans: cooperative recognition of mannans and glucan by lectin and Toll-like receptors Mihai G. Netea, Neil A.R. Gow, Carol A. Munro, Steven Bates, Claire Collins, Gerben Ferwerda, Richard P. Hobson, Gwyneth Bertram, H. Bleddyn Hughes, Trees Jansen, Liesbeth Jacobs, Ed T. Buurman, Karlijn Gijzen, David L. Williams, Ruurd Torensma, Alistair McKinnon, Frank C. Odds, Jos W.M. Van der Meer, Alistair J.P. Brown, Bart Jan Kullberg	Journal of Clinical Investigation	2006
Scavenger Receptor BI Prevents Nitric Oxide–Induced Cytotoxicity and Endotoxin-Induced Death XA Li, L Guo, R Asmis, M Nikolova-Karakashian, EJ Smart	Circulation research	2006
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Dyslipidemia in the Critically Ill PE Marik	Critical Care Clinics	2006
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis G Ferwerda, SE Girardin, BJ Kullberg, LL Bourhis, DJ de Jong, DM Langenberg, R Crevel, GJ Adema, TH Ottenhoff, JW van der Meer, MG Netea	PLoS pathogens	2005
Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis* JY Chien, JS Jerng, CJ Yu, PC Yang	Critical Care Medicine	2005
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Apolipoproteins modulate the inflammatory response to lipopolysaccharide JF Berbee, LM Havekes, PC Rensen	Journal of Endotoxin Research	2005
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LDL-receptor mutations in Europe GV Dedoussis, H Schmidt, J Genschel	Human Mutation	2004
Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease U Tursen, G Eskandari, TI Kaya, L Tamer, G Ikizoglu, U Atik	International Journal of Dermatology	2004
Toll-like receptor-4 Asp299Gly polymorphism does not influence progression of atherosclerosis in patients with familial hypercholesterolaemia MG Netea, A Hijmans, S Wissen, TJ Smilde, MD Trip, BJ Kullberg, T Boo, JW van der Meer, JJ Kastelein, AF Stalenhorf	European Journal of Clinical Investigation	2004
Recurrent perivascular inflammation induced by lipopolysaccharide (endotoxin) results in the formation of atheromatous lesions in vivo MG Engelmann, CV Redl, S Nikol	Laboratory Investigation	2004
Human lipoproteins have divergent neutralizing effects on E. coli LPS, N. meningitidis LPS, and complete Gram-negative bacteria T Sprong, MG Netea, P der Ley, TJ Verver-Jansen, LE Jacobs, A Stalenhoef, JW van der Meer, M Deuren	Journal of lipid research	2004
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Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock ES Amersfoort, TJ Berkel, J Kuiper	Clinical microbiology reviews	2003
Association of the −159 C → T polymorphism in the CD14 promoter with variations in serum lipoproteins in healthy subjects KE Eilertsen, JO Olsen, J Brox, B Østerud	Blood Coagulation & Fibrinolysis	2003
Cholesterol and mortality in heart failure: the bad gone good?**Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology GC Fonarow, TB Horwich	Journal of the American College of Cardiology	2003
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High cholesterol may protect against infections and atherosclerosis U Ravnskov	QJM	2003
Lung Biology in Health and Disease N Zamel	Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential	2003
Hyperlipoproteinemic low-density lipoprotein receptor-deficient mice are more susceptible to sepsis than corresponding wild-type mice S Lanza-Jacoby, S Miller, S Jacob, D Heumann, AG Minchenko, JT Flynn	Journal of Endotoxin Research	2003
Safety and Pharmacokinetics of an Endotoxin-Binding Phospholipid Emulsion BR Gordon, TS Parker, DM Levine, SD Saal, LC Hudgins, BJ Sloan, C Chu, KH Stenzel, AL Rubin	The Annals of pharmacotherapy	2003
Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1 T Mueller, R Gesner, C Sarrazin, C Graf, J Halangk, H Witt, E Kottgen, B Wiedenmann, T Berg	Hepatology	2003
Treatment of Intra-Abdominal Abscesses Caused by Candida albicans with Antifungal Agents and Recombinant MurineGranulocyte Colony-StimulatingFactor AG Vonk, MG Netea, JH van Krieken, PE Verweij, JW van der Meer, BJ Kullberg	Antimicrobial agents and chemotherapy	2003
Changes in the Plasma Lipid Profile as a Potential Predictor of Clinical Outcome in Dengue Hemorrhagic Fever EC van Gorp, C Suharti, AT Mairuhu, WM Dolmans, J der Ven, PN Demacker, JW van der Meer	Clinical Infectious Diseases	2002
Hepatic Endosomal Trafficking of Lipoprotein-Bound Endotoxin in Rats HW Harris, SE Brady, JH Rapp	Journal of Surgical Research	2002
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Lymphocyte Activation and Immune Regulation IX S Gupta, E Butcher, W Paul	Lymphocyte Activation and Immune Regulation IX	2002
Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection BJ Hennig, S Hellier, AJ Frodsham, L Zhang, P Klenerman, S Knapp, M Wright, HC Thomas, M Thursz, AV Hill	Genes and Immunity	2002
Role of Interleukin-18 in Host Defense against Disseminated Candida albicans Infection RJ Stuyt, MG Netea, I Verschueren, G Fantuzzi, CA Dinarello, JW der Meer, BJ Kullberg	Infection and immunity	2002
Lipopolysaccharide binding protein circulates associated with apoB containing lipoproteins and enhances endotoxin-LDL/VLDL interaction Anita C.E. Vreugdenhil, A.M. Patricia Snoek, Cornelis vant 't Veer, Jan-Willem M. Greve, Wim A. Buurman	Journal of Clinical Investigation	2001
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Cholesterol and all-cause mortality in Honolulu AW Weverling-Rijnsburger, GJ Blauw, RG Westendorp	The Lancet	2001
Mortality over two centuries in large pedigree with familial hypercholesterolaemia: family tree mortality study EJ Sijbrands, RG Westendorp, JC Defesche, PH de Meier, AH Smelt, JJ Kastelein	BMJ (Clinical research ed.)	2001
Reduced adrenal response to bacterial lipopolysaccharide in interleukin-6-deficient mice FH van Enckevort, CG Sweep, PN Span, PN Demacker, CC Hermsen, AR Hermus	Journal of Endocrinological Investigation	2001
Hypercholesterolemia Exacerbates Virus-Induced Immunopathologic Liver Disease Via Suppression of Antiviral Cytotoxic T Cell Responses B Ludewig, M Jäggi, T Dumrese, K Brduscha-Riem, B Odermatt, H Hengartner, RM Zinkernagel	Journal of immunology (Baltimore, Md. : 1950)	2001
APOLIPOPROTEINE: Far More Than a Lipid Transport Protein RW Mahley, SC Rall	Annual Review of Genomics and Human Genetics	2000
Chylomicron processing in familial dysbetalipoproteinemia and familial combined hyperlipidemia studied with vitamin A and E as markers: a new physiological concept PN Demacker, MP Hectors, AF Stalenhoef	Atherosclerosis	2000
Hyperlipoproteinemia affects cytokine production in whole blood samples ex vivo. The influence of lipid-lowering therapy MF Mohrschladt, AW Weverling-Rijnsburger, FH Man, DJ Stoeken, A Sturk, AH Smelt, RG Westendorp	Atherosclerosis	2000
Apolipoprotein E-deficient mice have an impaired immune response to Klebsiella pneumoniae de Bont, Netea, Demacker, Kullberg, van der Meer, Stalenhoef	European Journal of Clinical Investigation	2000
Regulation of Matrix Metalloproteinases and Their Inhibitor Genes in Lipopolysaccharide-Induced Endotoxemia in Mice A Pagenstecher, AK Stalder, CL Kincaid, B Volk, IL Campbell	The American Journal of Pathology	2000
The endotoxin-lipoprotein hypothesis M Rauchhaus, AJ Coats, SD Anker	The Lancet	2000
Predominance of a 6 bp deletion in exon 2 of the LDL receptor gene in Africans with familial hypercholesterolaemia R Thiart, CL Scholtz, J Vergotine, CF Hoogendijk, JN de Villiers, H Nissen, K Brusgaard, D Gaffney, MS Hoffs, WJ Vermaak, MJ Kotze	Journal of medical genetics	2000
A POLIPOPROTEIN E: Far More Than a Lipid Transport Protein RW Mahley, SC Rall	Annual Review of Genomics and Human Genetics	2000
Novel Cytokine Inhibitors GA Higgs, B Henderson		2000
Serum Amyloid P Component Prevents High-Density Lipoprotein-Mediated Neutralization of Lipopolysaccharide DL Burns, CJ de Haas, MJ Poppelier, KP van Kessel, JA van Strijp	Infection and immunity	2000
An IFN-γ-Independent Proinflammatory Role of IL-18 in Murine Streptococcal Cell Wall Arthritis LA Joosten, FA van de Loo, E Lubberts, MM Helsen, MG Netea, JW van der Meer, CA Dinarello, WB van den Berg	Journal of immunology (Baltimore, Md. : 1950)	2000
Increased susceptibility to systemic candidiasis in interleukin-6 deficient mice 1 FH van Enckevort, MG Netea, AR Hermus, CG Sweep, JF Meis, JW van der Meer, BJ Kullberg	Medical Mycology	1999
Variables Affecting Outcome in Critically Ill Patients B Chernow	Chest	1999
Anti-endotoxin properties of a cinnamon bark-derived compound and its effect on the endotoxin shock model S Azumi, K Tanamoto	Journal of Endotoxin Research	1999
Cytokines in Severe Sepsis and Septic Shock H Redl, G Schlag		1999
Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection N de Bont, MG Netea, PN Demacker, I Verschueren, BJ Kullberg, KW van Dijk, JW van der Meer, AF Stalenhoef	Journal of lipid research	1999
LPS-induced cytokine production and expression of LPS-receptors by peripheral blood mononuclear cells of patients with familial hypercholesterolemia and the effect of HMG-CoA reductase inhibitors N Bont, MG Netea, C Rovers, T Smilde, PN Demacker, JW van der Meer, AF Stalenhoef	Atherosclerosis	1998
LPS-induced cytokine production and expression of β2-integrins and CD14 by peripheral blood mononuclear cells of patients with homozygous familial hypercholesterolemia C Rovers, MG Netea, N Bont, PN Demacker, C Jacobs, BJ Kullberg, JW van der Meer, AF Stalenhoef	Atherosclerosis	1998
Lipopolysaccharide-induced production of tumour necrosis factor and interleukin-1 is differentially regulated at the receptor level: the role of CD14-dependent and CD14-independent pathways MG Netea, BJ Kullberg, JW van der Meer	Immunology	1998
Increased interleukin-1alpha and interleukin-1beta production by macrophages of low-density lipoprotein receptor knock-out mice stimulated with lipopolysaccharide is CD11c/CD18-receptor mediated MG Netea, PN Demacker, BJ Kullberg, OC Boerman, I Verschueren, AF Stalenhoef, JW van der Meer	Immunology	1998
Endotoxin-neutralizing protein protects against endotoxin-induced endothelial barrier dysfunction DD Bannerman, MJ Fitzpatrick, DY Anderson, AK Bhattacharjee, TJ Novitsky, JD Hasday, AS Cross, SE Goldblum	Infection and immunity	1998
Lipoprotein(a) Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Mononuclear Cells MG Netea, N de Bont, PN Demacker, BJ Kullberg, LE Jacobs, TJ Verver-Jansen, AF Stalenhoef, JW der Meer	Infection and immunity	1998
Lipopolysaccharide-induced production of tumour necrosis factor and interleukin-1 is differentially regulated at the receptor level: the role of CD14-dependent and CD14-independent pathways. Netea MG, Kullberg BJ, van der Meer JW	Immunology	1998
Total cholesterol and risk of mortality in the oldest old AW Weverling-Rijnsburger, GJ Blauw, AM Lagaay, DL Knock, AE Meinders, RG Westendorp	The Lancet	1997
The dense low-density lipoprotein (LDL) subfractions are more potent than buoyant LDL for binding and neutralization of lipopolysaccharide MG Netea, PN Demacker, T Verver-Jansen, L Jacobs, BJ Kullberg, AF Stalenhoef, JW van der Meer	Journal of Endotoxin Research	1997
The Role of Hyperuricemia in the Increased Cytokine Production After Lipopolysaccharide Challenge in Neutropenic Mice MG Netea, BJ Kullberg, WL Blok, RT Netea, JW der Meer	Blood	1997
Hyperlipoproteinemia enhances susceptibility to acute disseminated Candida albicans infection in low-density-lipoprotein-receptor-deficient mice MG Netea, PN Demacker, N de Bont, OC Boerman, AF Stalenhoef, JW van der Meer, BJ Kullberg	Infection and immunity	1997
Microbial/host interactions in health and disease: Who controls the cytokine network? B Henderson, S Poole, M Wilson	Immunopharmacology	1996

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