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Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

R Evers, … , P Borst, A H Schinkel

R Evers, … , P Borst, A H Schinkel

Published March 1, 1996
Citation Information: J Clin Invest. 1996;97(5):1211-1218. https://doi.org/10.1172/JCI118535.

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Allosteric Interactions between the Two Non-equivalent Nucleotide Binding Domains of Multidrug Resistance Protein MRP1 Y Hou, L Cui, JR Riordan, X Chang	The Journal of biological chemistry	2000
Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1) E Bakos, R Evers, G Calenda, GE Tusnady, G Szakacs, A Varadi, B Sarkadi	Journal of cell science	2000
Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein C Brimer, J T Dalton, Z Zhu, J Schuetz, K Yasuda, E Vanin, M V Relling, Y Lu, E G Schuetz	Pharmaceutical Research	2000
Development of multidrug-resistance convertors: sense or nonsense? L van Zuylen, K Nooter, A Sparreboom, J Verweij	Investigational New Drugs	2000
Role of P-glycoprotein in restricting propranolol transport in cultured rabbit conjunctival epithelial cell layers J J Yang, K J Kim, V H Lee	Pharmaceutical Research	2000
Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance J König, AT Nies, Y Cui, I Leier, D Keppler	Biochimica et Biophysica Acta (BBA) - Biomembranes	1999
An inventory of the human ABC proteins I Klein, B Sarkadi, A Váradi	Biochimica et Biophysica Acta (BBA) - Biomembranes	1999
P-glycoprotein, secretory transport, and other barriers to the oral delivery of anti-HIV drugs BJ Aungst	Advanced Drug Delivery Reviews	1999
Lysosomotropic agents increase vinblastine efflux from mouse MDR proximal kidney cells exhibiting vectorial drug transport R Lacave, Z Ouar, M Paulais, M Bens, S Ricci, F Cluzeaud, A Vandewalle	Journal of Cellular Physiology	1999
Effects of paclitaxel on the growth of normal, polyposis, and cancerous human colonic epithelial cells BC Sheppard, MJ Rutten, CL Meichsner, KD Bacon, PO Leonetti, J Land, RC Crass, DD Trunkey, KE Deveney, CW Deveney	Cancer	1999
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier VV Rao, JL Dahlheimer, ME Bardgett, AZ Snyder, RA Finch, AC Sartorelli, D Piwnica-Worms	Proceedings of the National Academy of Sciences	1999
Chronic Lung Disease in Early Infancy D Riley	Chronic Lung Disease in Early Infancy	1999
Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney A Tojo, T Sekine, N Nakajima, M Hosoyamada, Y Kanai, K Kimura, H Endou	Journal of the American Society of Nephrology : JASN	1999
Modeling of P-glycoprotein-involved epithelial drug transport in MDCK cells S Ito, C Woodland, B Sarkadi, G Hockmann, SE Walker, G Koren	American journal of physiology. Renal physiology	1999
Tissue and Cell Distribution of the Multidrug Resistance-Associated Protein (MRP) in Mouse Intestine and Kidney KC Peng, F Cluzeaud, M Bens, JP van Huyen, MA Wioland, R Lacave, A Vandewalle	Journal of Histochemistry & Cytochemistry	1999
pABC11 (Also Known as MOAT-C and MRP5), a Member of the ABC Family of Proteins, Has Anion Transporter Activity but Does Not Confer Multidrug Resistance When Overexpressed in Human Embryonic Kidney 293 Cells MA McAleer, MA Breen, NL White, N Matthews	The Journal of biological chemistry	1999
Interaction of docetaxel ("Taxotere") with human P-glycoprotein K Shirakawa, K Takara, Y Tanigawara, N Aoyama, M Kasuga, F Komada, T Sakaeda, K Okumura	Japanese journal of cancer research : Gann	1999
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis GA Meijer, AB Schroeijers, MJ Flens, SG Meuwissen, P van der Valk, JP Baak, RJ Scheper	Journal of clinical pathology	1999
Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics N Strazielle, J F Ghersi-Egea	The Journal of neuroscience : the official journal of the Society for Neuroscience	1999
The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane RJ Raggers, A van Helvoort, R Evers, G van Meer	Journal of cell science	1999
Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum S D Flanagan, L Z Benet	Pharmaceutical Research	1999
Demonstration of a Coupled Metabolism–Efflux Process at the Choroid Plexus as a Mechanism of Brain Protection Toward Xenobiotics Strazielle N, Ghersi-Egea JF	Journal of Neuroscience	1999
Interaction of Docetaxel (“Taxotere”) with Human P‐Glycoprotein Shirakawa K, Takara K, Tanigawara Y, Aoyama N, Kasuga M, Komada F, Sakaeda T, Okumura K	Japanese journal of cancer research : Gann	1999
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA R Evers, M Kool, L Deemter, H Janssen, J Calafat, LC Oomen, CC Paulusma, RP Elferink, F Baas, AH Schinkel, P Borst	Journal of Clinical Investigation	1998
The role of P-Glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs H Kusuhara, H Suzuki, Y Sugiyama	Journal of Pharmaceutical Sciences	1998
Renal transport of organic anions F Roch-Ramel	Current Opinion in Nephrology and Hypertension	1998
Multidrug Resistance Protein 1 Protects the Oropharyngeal Mucosal Layer and the Testicular Tubules against Drug-induced Damage J Wijnholds, GL Scheffer, M der Valk, P der Valk, JH Beijnen, RJ Scheper, P Borst	Journal of Experimental Medicine	1998
Development of an intrinsic P-glycoprotein-mediated doxorubicin resistance in quiescent cell layers of large, multicellular prostate tumor spheroids M Wartenberg, C Frey, H Diedershagen, J Ritgen, J Hescheler, H Sauer	International Journal of Cancer	1998
ATP-dependent transport of reduced glutathione in yeast secretory vesicles JF Rebbeor, GC Connolly, ME Dumont, N Ballatori	Biochemical Journal	1998
Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage J Wijnholds, GL Scheffer, M der Valk, P der Valk, JH Beijnen, RJ Scheper, P Borst	Journal of Experimental Medicine	1998
99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein NH Hendrikse, EJ Franssen, WT van der Graaf, C Meijer, DA Piers, W Vaalburg, EG de Vries	British Journal of Cancer	1998
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA R Evers, M Kool, L van Deemter, H Janssen, J Calafat, L C Oomen, C C Paulusma, R P Oude Elferink, F Baas, A H Schinkel, P Borst	Reproductive sciences (Thousand Oaks, Calif.)	1998
ATP-dependent Transport of Reduced Glutathione on YCF1, the Yeast Orthologue of Mammalian Multidrug Resistance Associated Proteins JF Rebbeor, GC Connolly, ME Dumont, N Ballatori	The Journal of biological chemistry	1998
Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain É Bakos, R Evers, G Szakács, GE Tusnády, E Welker, K Szabó, M Haas, L Deemter, P Borst, A Váradi, B Sarkadi	The Journal of biological chemistry	1998
Different Pattern of MRP Localization in Ciliated and Basal Cells from Human Bronchial Epithelium JM Bréchot, I Hurbain, A Fajac, N Daty, JF Bernaudin	Journal of Histochemistry & Cytochemistry	1998
Activation of ΔF508 CFTR in an epithelial monolayer Z Bebök, CJ Venglarik, Z Pánczél, T Jilling, KL Kirk, EJ Sorscher	American journal of physiology. Cell physiology	1998
Environmental Xenobiotics and the Antihormones Cyproterone Acetate and Spironolactone Use the Nuclear Hormone Pregnenolone X Receptor to Activate the CYP3A23 Hormone Response Element EG Schuetz, C Brimer, JD Schuetz	Molecular pharmacology	1998
Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells S Kinoshita, H Suzuki, K Ito, K Kume, T Shimizu, Y Sugiyama	Pharmaceutical Research	1998
In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with rapamycin A Crowe, M Lemaire	Pharmaceutical Research	1998
Fluoroquinolone (ciprofloxacin) secretion by human intestinal epithelial (Caco-2) cells ME Cavet, M West, NL Simmons	British Journal of Pharmacology	1997
Hepatobiliary elimination of cationic drugs: the role of P-glycoproteins and other ATP-dependent transporters DK Meijer, JW Smit, M Müller	Advanced Drug Delivery Reviews	1997
Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein J Madon, U Eckhardt, T Gerloff, B Stieger, PJ Meier	FEBS Letters	1997
Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1 R Evers, NH Cnubben, J Wijnholds, L Deemter, PJ van Bladeren, P Borst	FEBS Letters	1997
ATPase Activity of Purified Multidrug Resistance-associated Protein XB Chang, YX Hou, JR Riordan	The Journal of biological chemistry	1997
Characterization of Phosphine Complexes of Technetium(III) as Transport Substrates of the Multidrug Resistance P-Glycoprotein and Functional Markers of P-Glycoprotein at the Blood−Brain Barrier GD Luker, VV Rao, CL Crankshaw, J Dahlheimer, D Piwnica-Worms	Biochemistry	1997
Multidrug resistance mediated by the multidrug resistance protein (MRP) gene, D Lautier	Biochemical Pharmacology	1996
Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans A Broeks, B Gerrard, R Allikmets, M Dean, RH Plasterk	The EMBO Journal	1996
The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1 R Tommasini, R Evers, E Vogt, C Mornet, GJ Zaman, AH Schinkel, P Borst, E Martinoia	Proceedings of the National Academy of Sciences	1996
Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP GJ Zaman, NH Cnubben, PJ van Bladeren, R Evers, P Borst	FEBS Letters	1996

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