JCI - Citations to Toll-like receptor–mediated NF-κB activation: a phylogenetically conserved paradigm in innate immunity

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Toll-like receptor–mediated NF-κB activation: a phylogenetically conserved paradigm in innate immunity

Guolong Zhang, Sankar Ghosh

Guolong Zhang, Sankar Ghosh

Published January 1, 2001
Citation Information: J Clin Invest. 2001;107(1):13-19. https://doi.org/10.1172/JCI11837.

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The Metabolic Role of Gut Microbiota in the Development of Nonalcoholic Fatty Liver Disease and Cardiovascular Disease MS Zamparelli, D Compare, P Coccoli, A Rocco, O Nardone, G Marrone, A Gasbarrini, A Grieco, G Nardone, L Miele	International journal of molecular sciences	2016
Isorhamnetin ameliorates LPS-induced inflammatory response through downregulation of NF-κB signaling Y Li, G Chi, B Shen, Y Tian, H Feng	Inflammation	2016
Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages H Zhang, R Fu, C Guo, Y Huang, H Wang, S Wang, J Zhao, N Yang	Journal of Translational Medicine	2016
Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation QP Hu, DA Mao	BMC neuroscience	2016
Aneurysmal Subarachnoid Hemorrhage and Neuroinflammation: A Comprehensive Review B Lucke-Wold, A Logsdon, B Manoranjan, R Turner, E McConnell, G Vates, J Huber, C Rosen, J Simard	International journal of molecular sciences	2016
Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells DC Kim, CS Yoon, T Quang, W Ko, JS Kim, H Oh, YC Kim	International journal of molecular sciences	2016
Toll-like receptor 4 modulates the cochlear immune response to acoustic injury RR Vethanayagam, W Yang, Y Dong, BH Hu	Cell Death and Disease	2016
Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: Implications for extracranial origin of headache: Inflamed Periosteum in CM CJ Perry, P Blake, C Buettner, E Papavassiliou, AJ Schain, MK Bhasin, R Burstein	Annals of Neurology	2016
Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation JN Fullerton, E Segre, RP de Maeyer, AA Maini, DW Gilroy	Journal of visualized experiments : JoVE	2016
A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia CS Yoon, DC Kim, T Quang, J Seo, D Kang, H Lee, H Oh, YC Kim	Molecules (Basel, Switzerland)	2016
miR-146a-mediated suppression of the inflammatory response in human adipocytes J Roos, E Enlund, JB Funcke, D Tews, K Holzmann, KM Debatin, M Wabitsch, P Fischer-Posovszky	Scientific Reports	2016
NF-κB inhibition attenuates LPS-induced TLR4 activation in monocyte cells J Wan, Y Shan, Y Fan, C Fan, S Chen, J Sun, L Zhu, L Qin, M Yu, Z Lin	Molecular medicine reports	2016
Anti-inflammatory coumarins from Paramignya trimera HL Anh, DC Kim, W Ko, TM Ha, NX Nhiem, PH Yen, BH Tai, LH Truong, VN Long, T Gioi, TH Quang, CV Minh, H Oh, YC Kim, PV Kiem	Pharmaceutical Biology	2016
Esculin Inhibits the Inflammation of LPS-Induced Acute Lung Injury in Mice Via Regulation of TLR/NF-κB Pathways Z Tianzhu, W Shumin	Inflammation	2015
TLR2 and AP1/NF-kappaB are involved in the regulation of MMP-9 elicited by heat killed Listeria monocytogenes in human monocytic THP-1 cells PK Shihab, A Al-Roub, M Al-Ghanim, A Al-Mass, K Behbehani, R Ahmad	Journal of Inflammation	2015
“Boomerang Neuropathology” of Late-Onset Alzheimer’s Disease is Shrouded in Harmful “BDDS”: Breathing, Diet, Drinking, and Sleep During Aging MA Daulatzai	Neurotoxicity Research	2015
Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS B Parodi, S Rossi, S Morando, C Cordano, A Bragoni, C Motta, C Usai, BT Wipke, RH Scannevin, GL Mancardi, D Centonze, NK de Rosbo, A Uccelli	Acta Neuropathologica	2015
Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-κB Activation in Microglial Cells D Wang, J Shi, S Lv, W Xu, J Li, W Ge, C Xiao, D Geng, Y Liu	Inflammation	2015
Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression M Gao, X Wang, X Zhang, T Ha, H Ma, L Liu, JH Kalbfleisch, X Gao, RL Kao, DL Williams, C Li	Journal of immunology (Baltimore, Md. : 1950)	2015
Immunostimulatory activity of snake fruit peel extract on murine macrophage-like J774.1 cells S Wijanarti, AB Putra, K Nishi, E Harmayani, T Sugahara	Cytotechnology	2015
The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-κB Signaling Y Momiuchi, K Kumada, T Kuraishi, T Takagaki, T Aigaki, Y Oshima, S Kurata	The Journal of biological chemistry	2015
HIV-1 increases TLR responses in human primary astrocytes MJ Serramía, MÁ Muñoz-Fernández, S Álvarez	Scientific Reports	2015
Lipopolysaccharide modulates neutrophil recruitment and macrophage polarization on lymphatic vessels and impairs lymphatic function in rat mesentery S Chakraborty, SD Zawieja, W Wang, Y Lee, YJ Wang, PY der Weid, DC Zawieja, M Muthuchamy	American journal of physiology. Heart and circulatory physiology	2015
Central Regulation of Hypothalamic-Pituitary-Thyroid Axis Under Physiological and Pathophysiological Conditions C Fekete, RM Lechan	Endocrine reviews	2014
Toll-like receptor 3 plays a role in myocardial infarction and ischemia/reperfusion injury C Lu, D Ren, X Wang, T Ha, L Liu, EJ Lee, J Hu, J Kalbfleisch, X Gao, R Kao, D Williams, C Li	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2014
MicroRNA-125b protects against myocardial ischaemia/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6 X Wang, T Ha, J Zou, D Ren, L Liu, X Zhang, J Kalbfleisch, X Gao, D Williams, C Li	Cardiovascular Research	2014
Cell death paradigms in the pathogenesis of Mycobacterium tuberculosis infection DK Parandhaman, S Narayanan	Frontiers in Cellular and Infection Microbiology	2014
Isoflurane Protects Against Injury Caused by Deprivation of Oxygen and Glucose in Microglia Through Regulation of the Toll-Like Receptor 4 Pathway HF Xiang, DH Cao, YQ Yang, HQ Wang, LJ Zhu, BH Ruan, J Du, MC Wang	Journal of Molecular Neuroscience	2014
Differential MicroRNA Expression Profile between Stimulated PBMCs from HIV-1 Infected Elite Controllers and Viremic Progressors Lander Egaña-Gorroño, Tuixent Escribà, Nicolas Boulanger, Alberto Crespo Guardo, Agathe León, Manel Enric Bargalló, Felipe Garcia, José María Gatell, Montserrat Plana, Mireia Arnedo,	PloS one	2014
RETRACTED ARTICLE: Inhibition of Lipopolysaccharide (LPS)-Induced Inflammatory Responses by Selenium in Bovine Mammary Epithelial Cells in Primary Culture Z Wei, M Yao, Y Li, Z Yang, X Feng	Inflammation	2014
IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice Q Tan, M Majewska-Szczepanik, X Zhang, M Szczepanik, Z Zhou, FS Wong, L Wen	Diabetes	2014
Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection S Marino, NA Cilfone, JT Mattila, JJ Linderman, JA Flynn, DE Kirschner, S Ehrt	Infection and immunity	2014
Immunomodulatory Effects of ZYM-201 on LPS-stimulated B Cells YE Lee, S Kim, WJ Jung, HS Lee, MY Kim	Immune Network	2014
Gentiolactone, a Secoiridoid Dilactone from Gentiana triflora, Inhibits TNF-α, iNOS and Cox-2 mRNA Expression and Blocks NF-κB Promoter Activity in Murine Macrophages H Yamada, S Kikuchi, T Inui, H Takahashi, K Kimura, C Scavone	PloS one	2014
Toll‑like receptor‑4 pathway is required for the pathogenesis of human chronic endometritis J Ju, L Li, J Xie, Y Wu, X Wu, W Li	Experimental and therapeutic medicine	2014
Anti-Inflammatory Properties of the Medicinal Mushroom Cordyceps militaris Might Be Related to Its Linear (1→3)-β-D-Glucan FR Smiderle, CH Baggio, DG Borato, AP Santana-Filho, GL Sassaki, M Iacomini, LJ van Griensven, C Huang	PloS one	2014
Toll-like Receptors as a Target of Food-derived Anti-inflammatory Compounds T Shibata, F Nakashima, K Honda, YJ Lu, T Kondo, Y Ushida, K Aizawa, H Suganuma, S Oe, H Tanaka, T Takahashi, K Uchida	The Journal of biological chemistry	2014
Liang-Ge-San, a classic traditional Chinese medicine formula, protects against lipopolysaccharide-induced inflammation through cholinergic anti-inflammatory pathway JS Liu, XD Wei, ZB Lu, P Xie, HL Zhou, YY Chen, JM Ma, LZ Yu	Oncotarget	2014
Probiotic as a Novel Treatment Strategy Against Liver Disease AA Fooladi, HM Hosseini, MR Nourani, S Khani, SM Alavian	Hepatitis Monthly	2013
The role of gut microbiota in the pathogenesis of colorectal cancer Q Zhu, R Gao, W Wu, H Qin	Tumor Biology	2013
The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway M Cai, M Li, K Wang, S Wang, Q Lu, J Yan, KL Mossman, R Lin, C Zheng	PloS one	2013
Bupleurum polysaccharides attenuates lipopolysaccharide-induced inflammation via modulating Toll-like receptor 4 signaling J Wu, YY Zhang, L Guo, H Li, DF Chen	PloS one	2013
Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice D Lippai, S Bala, T Csak, EA Kurt-Jones, G Szabo	PloS one	2013
A computational model of lipopolysaccharide-induced nuclear factor kappa B activation: a key signalling pathway in infection-induced preterm labour GC Sharp, H Ma, PT Saunders, JE Norman	PloS one	2013
The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage KA Hanafy	Journal of Neuroinflammation	2013
Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages X Bai, NE Feldman, K Chmura, AR Ovrutsky, WL Su, L Griffin, D Pyeon, MT McGibney, MJ Strand, M Numata, S Murakami, L Gaido, JR Honda, WH Kinney, RE Oberley-Deegan, DR Voelker, DJ Ordway, ED Chan	PloS one	2013
Non-apoptotic toxicity of Pseudomonas aeruginosa toward murine cells S Roy, T Bonfield, AM Tartakoff	PloS one	2013
Endocytosis of Mycobacterium tuberculosis heat shock protein 60 is required to induce interleukin-10 production in macrophages N Parveen, R Varman, S Nair, G Das, S Ghosh, S Mukhopadhyay	The Journal of biological chemistry	2013
Anti-Inflammatory Effect of Neoechinulin A from the Marine Fungus Eurotium sp. SF-5989 through the Suppression of NF-кB and p38 MAPK Pathways in Lipopolysaccharide-Stimulated RAW264.7 Macrophages KS Kim, X Cui, DS Lee, J Sohn, J Yim, YC Kim, H Oh	Molecules (Basel, Switzerland)	2013
Rehmannia glutinosa Suppresses Inflammatory Responses Elicited by Advanced Glycation End Products GH Baek, YS Jang, SI Jeong, J Cha, M Joo, SW Shin, KT Ha, HS Jeong	Inflammation	2012
ANT1 is reduced in sporadic inclusion body myositis E Barca, M Aguennouz, A Mazzeo, S Messina, A Toscano, GL Vita, S Portaro, D Parisi, C Rodolico	Neurological Sciences	2012
Regulation of ROS Production and Vascular Function by Carbon Monoxide YK Choi, ED Por, YG Kwon, YM Kim	Oxidative medicine and cellular longevity	2012
Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors S Zhang, K Cheng, X Wang, H Yin	Bioorganic & Medicinal Chemistry	2012
Genomic analysis of between-cow variation in dermal fibroblast response to lipopolysaccharide S Kandasamy, DE Kerr	Journal of Dairy Science	2012
Herpesviral infection and Toll-like receptor 2 M Cai, M Li, C Zheng	Protein & Cell	2012
Airway epithelial regulation of allergic sensitization in asthma ME Poynter	Pulmonary Pharmacology & Therapeutics	2012
Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing LN Schulte, AJ Westermann, J Vogel	Nucleic Acids Research	2012
Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury X Wang, T Ha, L Liu, J Zou, X Zhang, J Kalbfleisch, X Gao, D Williams, C Li	Cardiovascular Research	2012
Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis TR Ozment, T Ha, KF Breuel, TR Ford, DA Ferguson, J Kalbfleisch, JB Schweitzer, JL Kelley, C Li, DL Williams	PLoS pathogens	2012
Ceramide and Toll-Like Receptor 4 Are Mobilized into Membrane Rafts in Response to Helicobacter pylori Infection in Gastric Epithelial Cells DY Lu, HC Chen, MS Yang, YM Hsu, HJ Lin, CH Tang, CH Lee, CK Lai, CJ Lin, WC Shyu, FY Lin, CH Lai, SR Blanke	Infection and immunity	2012
Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding T Siggers, AB Chang, A Teixeira, D Wong, KJ Williams, B Ahmed, J Ragoussis, IA Udalova, ST Smale, ML Bulyk	Nature Immunology	2011
HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration HM Gao, H Zhou, F Zhang, BC Wilson, W Kam, JS Hong	The Journal of neuroscience : the official journal of the Society for Neuroscience	2011
Inhaled innate immune ligands to prevent pneumonia SE Evans, MJ Tuvim, CJ Fox, N Sachdev, L Gibiansky, BF Dickey	British Journal of Pharmacology	2011
Arvelexin from Brassica rapa suppresses NF-κB-regulated pro-inflammatory gene expression by inhibiting activation of IκB kinase JS Shin, YS Noh, YS Lee, YW Cho, NI Baek, MS Choi, TS Jeong, E Kang, HG Chung, KT Lee	British Journal of Pharmacology	2011
Monocyte-Platelet Interaction Induces a Pro-Inflammatory Phenotype in Circulating Monocytes G Passacquale, P Vamadevan, L Pereira, C Hamid, V Corrigall, A Ferro	PloS one	2011
Chronic stress promotes lymphocyte reduction through TLR2 mediated PI3K signaling in a β-arrestin 2 dependent manner H Li, L Chen, Y Zhang, G Lesage, Y Zhang, Y Wu, G Hanley, S Sun, D Yin	Journal of Neuroimmunology	2011
Toll-like receptors: new players in myocardial ischemia/reperfusion injury T Ha, L Liu, J Kelley, R Kao, D Williams, C Li	Antioxidants & Redox Signaling	2011
TLR2 Ligand Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of Phosphoinositide 3-Kinase/Akt Signaling C Lu, L Liu, Y Chen, T Ha, J Kelley, J Schweitzer, JH Kalbfleisch, RL Kao, DL Williams, C Li	Journal of immunology (Baltimore, Md. : 1950)	2011
Inducible Innate Resistance of Lung Epithelium to Infection SE Evans, Y Xu, MJ Tuvim, BF Dickey	Annual Review of Physiology	2010
TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism T Ha, C Lu, L Liu, F Hua, Y Hu, J Kelley, K Singh, RL Kao, J Kalbfleisch, DL Williams, X Gao, C Li	American journal of physiology. Heart and circulatory physiology	2010
Pattern recognition via the toll-like receptor system in the human female genital tract K Nasu, H Narahara	Mediators of Inflammation	2010
Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation C Patrignani, DT Lafont, V Muzio, B Gréco, RH van Huijsduijnen, PF Zaratin	Journal of inflammation (London, England)	2010
NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS TH Harris, EH Wilson, ED Tait, M Buckley, S Shapira, J Caamano, D Artis, CA Hunter	Journal of Neuroimmunology	2010
Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains W Abate, AA Alghaithy, J Parton, KP Jones, SK Jackson	Journal of lipid research	2010
Human immunodeficiency virus type-1 group M quasispecies evolution: diversity and divergence in patients co-infected with active tuberculosis T Biru, T Lennemann, M Stürmer, C Stephan, G Nisius, J Cinatl, S Staszewski, LG Gürtler	Medical Microbiology and Immunology	2010
Tilapia Hepcidin 2-3 Peptide Modulates Lipopolysaccharide-induced Cytokines and Inhibits Tumor Necrosis Factor-α through Cyclooxygenase-2 and Phosphodiesterase 4D* V Rajanbabu, CY Pan, SC Lee, WJ Lin, CC Lin, CL Li, JY Chen	The Journal of biological chemistry	2010
Dendritic cell responses to self-assembled monolayers of defined chemistries SP Shankar, TA Petrie, AJ García, JE Babensee	Journal of biomedical materials research. Part A	2010
Leptospira santorosai Serovar Shermani Detergent Extract Induces an Increase in Fibronectin Production through a Toll-Like Receptor 2-Mediated Pathway YC Tian, CC Hung, YJ Li, YC Chen, MY Chang, TH Yen, HH Hsu, MS Wu, A Phillips, CW Yang, BA McCormick	Infection and immunity	2010
Cyclic stretch enhances the expression of Toll-like Receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-κB pathway KG Shyu, BW Wang, CM Lin, H Chang	Journal of Biomedical Science	2010
Inhibition of IκB Kinase-β Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity F Zhang, L Qian, PM Flood, JS Shi, JS Hong, HM Gao	The Journal of pharmacology and experimental therapeutics	2010
Glucose-Based Peritoneal Dialysis Fluids Downregulate Toll-Like Receptors and Trigger Hyporesponsiveness to Pathogen-Associated Molecular Patterns in Human Peritoneal Mesothelial Cells J Wu, X Yang, YF Zhang, YN Wang, M Liu, XQ Dong, JJ Fan, XQ Yu	Clinical and vaccine immunology : CVI	2010
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function Y Yan, G Dalmasso, HT Nguyen, TS Obertone, SV Sitaraman, D Merlin	PloS one	2009
Effects of chronic mild stress on the development of atherosclerosis and expression of toll-like receptor 4 signaling pathway in adolescent apolipoprotein E knockout mice H Gu, C Tang, K Peng, H Sun, Y Yang	Journal of biomedicine & biotechnology	2009
Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3beta pathway L Chen, Y Zhang, X Sun, H Li, G LeSage, A Javer, X Zhang, X Wei, Y Jiang, D Yin	Bioorganic & Medicinal Chemistry	2009
Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production EY So, BS Kim	Glia	2009
Angiotensin II upregulates Toll-like receptor 4 and enhances lipopolysaccharide-induced CD40 expression in rat peritoneal mesothelial cells J Wu, X Yang, YF Zhang, SF Zhou, R Zhang, XQ Dong, JJ Fan, M Liu, XQ Yu	Inflammation Research	2009
Oral administration of poly-gamma-glutamate induces TLR4- and dendritic cell-dependent antitumor effect TY Lee, YH Kim, SW Yoon, JC Choi, JM Yang, CJ Kim, JT Schiller, MH Sung, H Poo	Cancer Immunology, Immunotherapy	2009
The antibiotics doxycycline and minocycline inhibit the inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi AL Bernardino, D Kaushal, MT Philipp	The Journal of Infectious Diseases	2009
Inhaled therapeutics for prevention and treatment of pneumonia A Safdar, SA Shelburne, SE Evans, BF Dickey	Expert Opinion on Drug Safety	2009
Nuclear factor-kappaB is a critical mediator of Ste20-like proline-/alanine-rich kinase regulation in intestinal inflammation Y Yan, G Dalmasso, HT Nguyen, TS Obertone, L Charrier-Hisamuddin, SV Sitaraman, D Merlin	The American Journal of Pathology	2008
Immune regulation of bone loss by Th17 cells IE Adamopoulos, EP Bowman	Arthritis Research & Therapy	2008
Chronic restraint stress promotes immune suppression through toll-like receptor 4-mediated phosphoinositide 3-kinase signaling Y Zhang, Y Zhang, J Miao, G Hanley, C Stuart, X Sun, T Chen, D Yin	Journal of Neuroimmunology	2008
Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes H Kim, E Yang, J Lee, SH Kim, JS Shin, JY Park, SJ Choi, SJ Kim, IH Choi	Immunology	2008
The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant X Liu, LM Wetzler, P Massari	Vaccine	2008
SN52, a novel nuclear factor-κB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation Y Xu, F Fang, DK Clair, P Sompol, S Josson, WH Clair	Molecular cancer therapeutics	2008
Increased In Vivo Activation of Microglia and Astrocytes in the Brains of Mice Transgenic for an Infectious R5 Human Immunodeficiency Virus Type 1 Provirus and for CD4-Specific Expression of Human Cyclin T1 in Response to Stimulation by Lipopolysaccharides J Sun, JH Zheng, M Zhao, S Lee, H Goldstein	Journal of virology	2008
Hormonal control of the renal immune response and antibacterial host defense by arginine vasopressin C Chassin, MW Hornef, M Bens, M Lotz, JM Goujon, S Vimont, G Arlet, A Hertig, E Rondeau, A Vandewalle	Journal of Experimental Medicine	2007
Innate immunity and antimicrobial defense systems in psoriasis AS Büchau, RL Gallo	Clinics in Dermatology	2007
Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion F Hua, J Ma, T Ha, Y Xia, J Kelley, DL Williams, RL Kao, IW Browder, JB Schweitzer, JH Kalbfleisch, C Li	Journal of Neuroimmunology	2007
Mesangial cells of lupus-prone mice are sensitive to chemokine production SM Ka, CW Cheng, HA Shui, WM Wu, DM Chang, YC Lin, A Chen	Arthritis Research & Therapy	2007
Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis H Zhu, Y Tang, L Ivanciu, M Centola, C Lupu, FB Taylor, F Lupu	BMC Genomics	2007
Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCε and JAK2 in RAW macrophages E Jones, IM Adcock, BY Ahmed, NA Punchard	Journal of Inflammation	2007
Commensal bacteria and epithelial cross talk in the developing intestine. Rautava S, Walker WA	Current Gastroenterology Reports	2007
Attenuation of Colonic Inflammation by PPARγ in Intestinal Epithelial Cells: Effect on Toll-like Receptor Pathway CS Eun, DS Han, SH Lee, CH Paik, YW Chung, J Lee, JS Hahm	Digestive Diseases and Sciences	2006
Differential modulatory effects of annexin 1 on nitric oxide synthase induction by lipopolysaccharide in macrophages T Smyth, HJ Harris, A Brown, S Tötemeyer, BA Farnfield, DJ Maskell, M Matsumoto, R Plevin, LC Alldridge, CE Bryant	Immunology	2006
Escherichia coli Prevents Phagocytosis-Induced Death of Macrophages via Classical NF-κB Signaling, a Link to T-Cell Activation HV Groesdonk, S Schlottmann, F Richter, M Georgieff, U Senftleben	Infection and immunity	2006
Down-regulation of IL-8 expression in human airway epithelial cells through helper-dependent adenoviral-mediated RNA interference H CAO, A WANG, B MARTIN, DR KOEHLER, PL ZEITLIN, AK TANAWELL, J HU	Cell Research	2005
Innate mechanisms for Bifidobacterium lactis to activate transient pro-inflammatory host responses in intestinal epithelial cells after the colonization of germ-free rats PA Ruiz, M Hoffmann, S Szcesny, M Blaut, D Haller	Immunology	2005
Construction of predictive promoter models on the example of antibacterial response of human epithelial cells E Shelest, E Wingender	Theoretical biology & medical modelling	2005
Gene expression profiling reveals a signaling role of glutathione in redox regulation M Fratelli, LO Goodwin, UA Ørom, S Lombardi, R Tonelli, M Mengozzi, P Ghezzi	Proceedings of the National Academy of Sciences	2005
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation S Sanjabi, KJ Williams, S Saccani, L Zhou, A Hoffmann, G Ghosh, S Gerondakis, G Natoli, ST Smale	Genes & development	2005
Chlamydophila pneumoniae induces expression of Toll-like Receptor 4 and release of TNF-α and MIP-2 via an NF-κB pathway in rat type II pneumocytes H Wissel, C Schulz, P Koehne, E Richter, M Maass, M Rüdiger	Respiratory Research	2005
Novel biomarker of HTLV‐1‐associated disease: Specific appearance of antibody recognizing the receptor‐binding site on HTLV‐1 envelope protein Sagara Y, Inoue Y, Tsujimura M, Kojima E, Shiraki H, Kashiwagi S	Cancer Science	2005
Receptor for Advanced Glycation End Products (RAGE) Regulating Sepsis but not the Adaptive Immune Response Birgit Liliensiek, Markus A. Weigand, Angelika Bierhaus, Werner Nicklas, Michael Kasper, Stefan Hofer, Jens Plachky, Herman-Josef Gröne, Ann Marie Schmidt, Shi Du Yan, Eike Martin, David M. Stern, Günter J. Hämmerling, Peter P. Nawroth, Bernd Arnold	Journal of Clinical Investigation	2004
Functions of NF-κB1 and NF-κB2 in immune cell biology S BEINKE, SC LEY	Biochemical Journal	2004
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E KS Michelsen, MH Wong, PK Shah, W Zhang, J Yano, TM Doherty, S Akira, TB Rajavashisth, M Arditi	Proceedings of the National Academy of Sciences	2004
Identification of a human NF-kappaB-activating protein, TAB3 G Jin, A Klika, M Callahan, B Faga, J Danzig, Z Jiang, X Li, GR Stark, J Harrington, B Sherf	Proceedings of the National Academy of Sciences	2004
CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan-polysaccharide complexes of Gram-positive bacterial cell walls X Li, BU Bradford, F Dalldorf, SM Goyert, SA Stimpson, RG Thurman, SS Makarov	Arthritis Research & Therapy	2004
Differential effect of immune cells on non-pathogenic Gram-negative bacteria-induced nuclear factor-kappaB activation and pro-inflammatory gene expression in intestinal epithelial cells D Haller, L Holt, A Parlesak, J Zanga, A Bäuerlein, RB Sartor, C Jobin	Immunology	2004
The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10 MK Dahle, G Øverland, AE Myhre, JF Stuestøl, T Hartung, CD Krohn, Ø Mathiesen, JE Wang, AO Aasen	Infection and immunity	2004
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response NT Liberati, KA Fitzgerald, DH Kim, R Feinbaum, DT Golenbock, FM Ausubel	Proceedings of the National Academy of Sciences	2004
Rac GTPase Instructs Nuclear Factor-κB Activation by Conveying the SCF Complex and IkBα to the Ruffling Membranes L Boyer, S Travaglione, L Falzano, NC Gauthier, MR Popoff, E Lemichez, C Fiorentini, A Fabbri	Molecular biology of the cell	2004
Human Immunodeficiency Virus Type 1 Protease Inhibitors Block Toll-Like Receptor 2 (TLR2)- and TLR4-Induced NF-κB Activation O Equils, A Shapiro, Z Madak, C Liu, D Lu	Antimicrobial agents and chemotherapy	2004
TRAF6-Dependent Mitogen-Activated Protein Kinase Activation Differentially Regulates the Production of Interleukin-12 by Macrophages in Response to Toxoplasma gondii NJ Mason, J Fiore, T Kobayashi, KS Masek, Y Choi, CA Hunter	Infection and immunity	2004
The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia. Sharma L, Melis E, Hickey MJ, Clyne CD, Erlich J, Khachigian LM, Davenport P, Morand E, Carmeliet P, Tipping PG	The American Journal of Pathology	2004
A molecular modeling study of inhibitors of nuclear factor kappa-B (p50) – DNA binding V Pande, RK Sharma, JI Inoue, M Otsuka, MJ Ramos	Journal of Computer-Aided Molecular Design	2003
Apoptosis and NF-kB: FADD connection Colin Duckett	Journal of Clinical Investigation	2002
Comparison of Inflammation, Organ Damage, and Oxidant Stress Induced by Salmonella enterica Serovar Muenchen Flagellin and Serovar Enteritidis Lipopolysaccharide L Liaudet, KG Murthy, JG Mabley, P Pacher, FG Soriano, AL Salzman, C Szabó	Infection and immunity	2002
Increased production of pro-inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD40 ligand A Wesa, A Galy	BMC Immunology	2002
Induction of keratinocyte growth factor 1 Expression by lipopolysaccharide is regulated by CD-14 and toll-like receptors 2 and 4 EE Putnins, AR Sanaie, Q Wu, JD Firth	Infection and immunity	2002
Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells MW Hornef, T Frisan, A Vandewalle, S Normark, A Richter-Dahlfors	Journal of Experimental Medicine	2002
Identification of NF-κB-Dependent Gene Networks in Respiratory Syncytial Virus-Infected Cells B Tian, Y Zhang, BA Luxon, RP Garofalo, A Casola, M Sinha, AR Brasier	Journal of virology	2002
Differences in Innate Immune Responses (In Vitro) to HeLa Cells Infected with Nondisseminating Serovar E and Disseminating Serovar L2 of Chlamydia trachomatis S Dessus-Babus, TL Darville, FP Cuozzo, K Ferguson, PB Wyrick	Infection and immunity	2002
Conjugation of Smt3 to Dorsal May Potentiate the Drosophila Immune Response V Bhaskar, M Smith, AJ Courey	Molecular and cellular biology	2002
Host-Pathogen Interactions: Subversion and Utilization of the NF-κB Pathway during Infection CM Tato, CA Hunter	Infection and immunity	2002
Host Immune Response to Salmonella enterica Serovar Typhimurium Infection in Mice Derived from Wild Strains G Sebastiani, V Blais, V Sancho, SN Vogel, MM Stevenson, P Gros, JM Lapointe, S Rivest, D Malo	Infection and immunity	2002
Effect of cholecystokinin octapeptide on tumor necrosis factor α transcription and nuclear factor-κB activity induced by lipopolysaccharide in rat pulmonary interstitial macrophages Cong B, Li SJ, Yao YX, Zhu GJ, Ling YL	World Journal of Gastroenterology	2002
The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. Lehnardt S, Lachance C, Patrizi S, Lefebvre S, Follett PL, Jensen FE, Rosenberg PA, Volpe JJ, Vartanian T	The Journal of neuroscience : the official journal of the Society for Neuroscience	2002
The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS Lehnardt S, Lachance C, Patrizi S, Lefebvre S, Follett PL, Jensen FE, Rosenberg PA, Volpe JJ, Vartanian T	Journal of Neuroscience	2002
Haploinsufficiency of peroxisome proliferator-activated receptor-gamma affects the B cell proliferative response and the severity of experimentally-induced arthritis Keigo Setoguchi, Yoshikata Misaki, Yasuo Terauchi, Toshimasa Yamauchi, Kimito Kawahata, Takashi Kadowaki, Kazuhiko Yamamoto	Journal of Clinical Investigation	2001

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