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Citations to this article

Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways.
S Tsuyuki, … , G P Anderson, A J Coyle
S Tsuyuki, … , G P Anderson, A J Coyle
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2924-2931. https://doi.org/10.1172/JCI118364.
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Research Article Article has an altmetric score of 3

Activation of the Fas receptor on lung eosinophils leads to apoptosis and the resolution of eosinophilic inflammation of the airways.

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Abstract

While considerable progress has been made in understanding the events by which eosinophils accumulate in various pathophysiological conditions, the mechanisms controlling the resolution of eosinophilic inflammation are poorly understood. In the present study, we demonstrate that lung eosinophils obtained by bronchoalveolar lavage (BAL) after aerosol allergen provocation of immunized mice expressed the Fas receptor. Stimulation of purified eosinophils in vitro with a monoclonal anti-Fas mAb (1 ng-1 microg/ml) induced a dose/time dependent loss of cell viability from 24-72 h. Measurement of DNA fragmentation with propidium iodide confirmed that anti-Fas induced eosinophil death by apoptosis. While incubation with IL-3, IL-5, or GM-CSF prevented spontaneous apoptosis, these factors failed to prevent anti-Fas induced apoptosis. Administration of anti-Fas mAb to the lungs after the induction of a lung eosinophilia increased the number of peroxidase positive macrophages in BAL fluid 4-12 h later which was followed by a marked reduction in the number of eosinophils in the airways. Importantly, Fas-mediated resolution of eosinophilic inflammation occurred in the absence of any overt secondary inflammatory changes in the lungs. We speculate that defects in this pathway may at least in part explain the chronic eosinophilic inflammation often observed in the lungs of asthmatic individuals.

Authors

S Tsuyuki, C Bertrand, F Erard, A Trifilieff, J Tsuyuki, M Wesp, G P Anderson, A J Coyle

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Total citations by year

Year: 2020 2018 2017 2015 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 2 2 2 1 2 1 3 2 2 6 1 6 4 10 2 8 8 16 10 13 8 2 111
Citation information
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Citations to this article in year 2018 (2)

Title and authors Publication Year
DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator
M Peinhaupt, D Roula, A Theiler, M Sedej, R Schicho, G Marsche, EM Sturm, I Sabroe, ME Rothenberg, A Heinemann
Journal of leukocyte biology 2018
OK-432 Acts as Adjuvant to Modulate T Helper 2 Inflammatory Responses in a Murine Model of Asthma
CJ Wu, PH Tseng, CC Chan, S Quon, LC Chen, ML Kuo
Journal of Immunology Research 2018

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