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Citations to this article

Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.
R E Fleming, … , A Waheed, W S Sly
R E Fleming, … , A Waheed, W S Sly
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2907-2913. https://doi.org/10.1172/JCI118362.
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Research Article Article has an altmetric score of 3

Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.

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Abstract

Carbonic anhydrase IV (CA IV) is a glycosylphosphatidylinositol-linked isozyme previously identified on the surface of renal tubular epithelium and certain populations of vascular endothelium. This report identifies the regional, cellular, and subcellular localization of CA IV in the rat gut. Northern blot and RT-PCR analyses demonstrated little CA IV expression in stomach or proximal small intestine, but abundant expression in distal small and large intestine. In contrast, CA II mRNA was abundant in stomach, decreased in proximal small intestine, low in distal small intestine, and abundant in large intestine. CA I mRNA was detected only in large intestine. The regional distribution of CA IV activity correlated with distribution of CA IV mRNA. Immunohistochemistry localized CA IV to the apical plasma membrane of the mucosal epithelium in distal small intestine and large intestine. Signal intensity was greatest in colon. CA IV was additionally found in submucosal capillary endothelium of all gastrointestinal regions. Immunohistochemical findings in human stomach and colon paralleled those in the rat. These studies demonstrate pre-translational isozyme-specific regulation of CA expression along the cranial-caudal axis of the gastrointestinal tract. The regional, cellular, and subcellular localizations are consistent with participation of CA IV in the extensive ion and fluid transport in the distal small and large intestine.

Authors

R E Fleming, S Parkkila, A K Parkkila, H Rajaniemi, A Waheed, W S Sly

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Citations to this article in year 2012 (3)

Title and authors Publication Year
Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes
ME Tolvanen, C Ortutay, HR Barker, A Aspatwar, M Patrikainen, S Parkkila
Bioorganic & Medicinal Chemistry 2012
Characterization of the carbonic anhydrases 15b expressed in PGCs during early zebrafish development
H Wang, Y Teng, Y Xie, B Wang, Y Leng, H Shu, F Deng
Theriogenology 2012
Regulatory Dendritic Cells Pulsed with Carbonic Anhydrase I Protect Mice from Colitis Induced by CD4 + CD25 − T Cells
H Yamanishi, H Murakami, Y Ikeda, M Abe, T Kumagi, Y Hiasa, B Matsuura, M Onji
Journal of immunology (Baltimore, Md. : 1950) 2012

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