Citations to this article

Genetic instability in patients with Hodgkin's disease undergoing chemotherapy.
J M Abdallah, … , D P Lombardi, I R Kirsch
J M Abdallah, … , D P Lombardi, I R Kirsch
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2744-2747. https://doi.org/10.1172/JCI118343.
View: Text | PDF
Research Article

Genetic instability in patients with Hodgkin's disease undergoing chemotherapy.

Abstract

We have studied the effect of chemotherapy on the level of a particular kind of genetic instability in patients with Hodgkin's disease. The particular type of genetic instability assayed is exemplified by trans-rearrangements between two (rather than within one) T cell antigen receptor. 16 patients were studied during their course of treatment. Presentation samples were available for 13 of these patients; 9 of them showed an increase in the level of trans-rearrangements during their exposure to chemotherapeutic agents (P < 0.043). All patients for whom posttherapy samples were available (10 out of 16) showed a return to baseline levels of trans-rearrangements 1-5 mo after completion of therapy (P < 0.03). Thus, this assay appears to be a marker for the "destabilizing" effects of certain chemotherapeutic agents.

Authors

J M Abdallah, D P Lombardi, I R Kirsch

×

Total citations by year

Year: 2018 2014 2009 2006 2005 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 1 1 3 1 2 1 1 3 2 2 3 3 2 25
Citation information

Citations to this article (25)

Title and authors Publication Year
Ionizing radiation does not impair the mechanisms controlling genetic stability during T cell receptor gene rearrangement in mice
SM Candéias, S Kabacik, AK Olsen, DM Eide, DA Brede, S Bouffler, C Badie 		International Journal of Radiation Biology 2018
Illegitimate recombination between T cell receptor genes in humans and pigs (Sus scrofa domestica)
P Musilova, J Drbalova, S Kubickova, H Cernohorska, H Stepanova, J Rubes 		Chromosome Research 2014
Occurrence of TRGV-BJ hybrid gene in SV40-transformed fibroblast cell lines
LP D’Arce, CL Bassi, AL Fachin, GA Passos, ET Sakamoto-Hojo 		Genetica 2009
Preferential induction of MLL (Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide
MS Brassesco, AP Montaldi, ET Sakamoto-Hojo 		Genetics and molecular biology 2009
Occurrence of TRGV-BJ hybrid gene in SV40-transformed fibroblast cell lines
LP DArce, CL Bassi, AL Fachin, GA Passos, ET Sakamoto-Hojo 		Genetica 2009
TCR trans -Rearrangements: Biological Significance in Antigen Recognition vs the Role as Lymphoma Biomarker
A Allam, D Kabelitz 		Journal of immunology (Baltimore, Md. : 1950) 2006
Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus
SG Grant 		BMC Pediatrics 2005
HPRT gene alterations in umbilical cord blood T-lymphocytes in newborns of mothers exposed to tobacco smoke during pregnancy
P Keohavong, L Xi, RD Day, L Zhang, SG Grant, BW Day, RB Ness, WL Bigbee 		Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2005
Quantitation of aberrant interlocus T-cell receptor rearrangements in mouse thymocytes and the effect of the herbicide 2,4-dichlorophenoxyacetic acid
GW Knapp, RW Setzer, JC Fuscoe 		Environmental and Molecular Mutagenesis 2003
Acute Cytogenetic Effects of Antineoplastic Drugs on Peripheral Blood Lymphocytes in Cancer Patients Chromosome Aberrations and Micronuclei
N Kopjar, V Garaj-Vrhovac, I Milas 		TUMORI 2002
Analysis of Vgamma/Jbeta trans-rearrangements in paediatric patients undergoing chemotherapy
LF Lopes, ED Neto, I Lorand-Metze, MR Latorre, AJ Simpson 		British Journal of Haematology 2001
Biomarker correlations of urinary 2,4-D levels in foresters: genomic instability and endocrine disruption
VF Garry, RE Tarone, IR Kirsch, JM Abdallah, DP Lombardi, LK Long, BL Burroughs, DB Barr, JS Kesner 		Environmental Health Perspectives 2001
Biomarker Correlations of Urinary 2,4-D Levels in Foresters: Genomic Instability and Endocrine Disruption
VF Garry, RE Tarone, IR Kirsch, JM Abdallah, DP Lombardi, LK Long, BL Burroughs, DB Barr, JS Kesner 		Environmental Health Perspectives 2001
Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines
S Lew, D Franco, Y Chang 		Molecular and cellular biology 2000
Cell-surface expression of transrearranged Vgamma-cbeta T-cell receptor chains in healthy donors and in ataxia telangiectasia patients
T Hinz, A Allam, D Wesch, D Schindler, D Kabelitz 		British Journal of Haematology 2000
Sj�gren's syndrome: Lymphoma predisposition coupled with a reduced frequency of t(14;18) translocations in blood lymphocytes
G Henriksson, M Brant, Z Sandor, R Manthorpe, A Bredberg 		Molecular Carcinogenesis 1999
The frequency of illegitimate TCRβ/γ gene recombination in human lymphocytes: influence of age, environmental exposure and cytostatic treatment, and correlation with frequencies of t(14;18) and hprt mutation
D Meydan, T Nilsson, M Törnblom, L Hagmar, D Hellgren, JC Fuscoe, B Lambert 		Mutation Research/Genetic Toxicology and Environmental Mutagenesis 1999
A human lymphoid leukemia cell line with a V(D)J recombinase-mediated deletion of hprt
CL Chen, MH Woo, GA Neale, RM Goorha, JC Fuscoe, FG Behm, S Mathew, MV Relling 		Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1998
The frequency of illegitimate V(D)J recombinase-mediated mutations in children treated with etoposide-containing antileukemic therapy
JC Fuscoe, GW Knapp, NM Hanley, RW Setzer, JT Sandlund, CH Pui, MV Relling 		Mutation Research/Genetic Toxicology and Environmental Mutagenesis 1998
Chromosome Breaks and Sister Chromatid Exchange as Predictors of Second Cancers in Hodgkin's Disease
SS Strom, Y Gu, AJ Sigurdson, NM Bailey, CI Amos, MR Spitz, MA Rodriguez, JC Liang 		Leukemia & Lymphoma 1998
Frequency and cell specificity of T-cell receptor interlocus recombination in human cells
D Meydan, B Lambert, D Hellgren 		Environmental and Molecular Mutagenesis 1997
Molecular epidemiology of hematological neoplasms—Present status and future directions
O Shpilberg, JS Dorman, A Shahar, LH Kuller 		Leukemia Research 1997
Trans-rearrangements and the risk of lymphoid malignancy
IR Kirsch 		Annals of Oncology 1997
Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
H Kanzler, R Küppers, ML Hansmann, K Rajewsky 		Journal of Experimental Medicine 1996
Haematologic Malignancy Secondary to the Treatment of Lymphoma
I Aronson, P Jacobs 		Hematology 1996

Advertisement