While it is well established that acute allergic urticaria is caused by degranulation of skin mast cells occurring after allergen/IgE-dependent cross-linking of high affinity IgE receptors (FcepsilonRI), the pathophysiologic mechanisms operative in chronic urticaria (CU) are less well understood. Some evidence points to the existence of histamine-releasing activity in the serum of CU patients which possibly acts via triggering of FcepsilonRI. In this study, we aimed to better characterize this anti-FcepsilonRIalpha reactivity of CU patients using affinity-purified, IgE-depleted IgG fractions of such individuals (CU-IgG). Using immobilized, recombinant soluble FcepsilonRIalpha as a a reaction target for Western blot studies, we found that 12/32 (37%) CU-IgG serum samples exhibited IgG autoreactivity against FcepsilonRI- alpha. These findings were confirmed by experiments demonstrating that immunoblot-reactive, but not immunoblot-nonreactive, CU-IgG preparations precipitated the FcepsilonRIalpha from FcepsilonRI- alphagamma-transfected cells. No anti-FcepsilonRIalpha reactivity was observed in IgG fractions from atopic dermatitis (AD) patients (0/15) or healthy control individuals (CO:0/15). As opposed to the selective occurrence of IgG anti-Fc epsilon RI alpha autoantibodies in CU patients, IgG anti-IgE antibodies were detected in all groups investigated (CU: 69%; AD: 73%; CO: 26%). While both types of autoantibodies can exhibit histamine-releasing properties, not all of the autoantibodies proved to be functional in vitro. Our results indicate that the occurrence of IgG anti-FcepsilonRIalpha reactivity defines an autoimmune-mediated subentity of CU and provide a basis for the development of new diagnostic procedures and, perhaps, therapeutic strategies for this disease.
E Fiebiger, D Maurer, H Holub, B Reininger, G Hartmann, M Woisetschläger, J P Kinet, G Stingl
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Clinical & Experimental Allergy | 2004 |
Natural anti-FcεRIα autoantibodies may interfere with diagnostic tests for autoimmune urticaria
JM Pachlopnik, MP Horn, M Fux, M Dahinden, M Mandallaz, D Schneeberger, L Baldi, M Vogel, BM Stadler, SM Miescher |
Journal of Autoimmunity | 2004 |
Low stimulated IL-4 secretion in PBMC from patients with chronic idiopathic urticaria
R Confino-Cohen, A Goldberg, D Aharoni, L Naiman, A Buchs, M Weiss, J Weissgarten, MJ Rapoport |
Cytokine | 2004 |
Hypersensitivity to aspirin: Common eicosanoid alterations in urticaria and asthma
L Mastalerz, M Setkowicz, M Sanak, A Szczeklik |
Journal of Allergy and Clinical Immunology | 2004 |
Chronic Urticaria: Aetiology, Management and Current and Future Treatment Options
MM Kozel, RA Sabroe |
Drugs | 2004 |
Impact of hydroxychloroquine therapy on chronic urticaria: chronic autoimmune urticaria study and evaluation: Hydroxychloroquine and chronic urticaria
GE Reeves, MJ Boyle, J Bonfield, P Dobson, M Loewenthal |
Internal Medicine Journal | 2004 |
Autoreaktive Urtikaria und Autoimmunurtikaria
M Maurer, M Metz, M Magerl, F Siebenhaar, P Staubach |
Der Hautarzt | 2004 |
High prevalence of IgG and IgA antibodies to 19-kDa Helicobacter pylori-associated lipoprotein in chronic urticaria
N Bakos, B Fekete, Z Prohaszka, G Fust, L Kalabay |
Allergy | 2003 |
Chronic urticaria and autoimmune thyroid disease: is there a link?
M Rottem |
Autoimmunity Reviews | 2003 |
Comparison of chronic autoimmune urticaria with chronic idiopathic urticaria
N Bakos, M Hillander |
International Journal of Dermatology | 2003 |
Swollen lips and a tender neck
CM Edwards, JJ Cream, J Cassar |
Journal of the Royal Society of Medicine | 2003 |
Circulating stem cell factor in patients with chronic idiopathic urticaria
R Asero, A Tedeschi, M Lorini, M Gerosa, P Meroni, P Riboldi |
Annals of Allergy Asthma & Immunology | 2003 |
Antithyroid antibodies in chronic urticaria and angioedema
Y Kikuchi, T Fann, AP Kaplan |
Journal of Allergy and Clinical Immunology | 2003 |
11. Allergic and immunologic diseases of the skin
A Blauvelt, ST Hwang, MC Udey |
Journal of Allergy and Clinical Immunology | 2003 |
Intolerance to nonsteroidal anti-inflammatory drugs might precede by years the onset of chronic urticaria
R Asero |
Journal of Allergy and Clinical Immunology | 2003 |
Association of chronic urticaria with thyroid autoimmunity and Raynaud phenomenon with anticentromere antibodies
R Asero, M Lorini, A Tedeschi, CS Carlo |
Journal of Allergy and Clinical Immunology | 2003 |
Sex differences in the pathogenesis of chronic urticaria
R Asero |
Journal of Allergy and Clinical Immunology | 2003 |
La ciclosporina en el tratamiento de la urticaria crónica idiopática
MR Pibernat, N Fernández-Chico |
Piel | 2003 |
Chronic idiopathic urticaria:
MW Greaves |
Current Opinion in Allergy and Clinical Immunology | 2003 |
Chronic Urticaria: A Role for Newer Immunomodulatory Drugs?
A Tedeschi, L Airaghi, M Lorini, R Asero |
American Journal of Clinical Dermatology | 2003 |
Molecular aspects of allergy
SM Miescher, M Vogel |
Molecular Aspects of Medicine | 2002 |
Reactivity to autologous serum skintest and clinical features in chronic idiopathic urticaria
E Nettis, P Dambra, L D'Oronzio, E Cavallo, MP Loria, M Fanelli, A Ferrannini, A Tursi |
Clinical and Experimental Dermatology | 2002 |
Increased Expression of Endothelial Cell Adhesion Molecules Due to Mediator Release from Human Foreskin Mast Cells Stimulated by Autoantibodies in Chronic Urticaria Sera
KH Lee, JY Kim, DS Kang, YJ Choi, WJ Lee, JY Ro |
Journal of Investigative Dermatology | 2002 |
Chronic Urticaria and Angioedema
AP Kaplan |
New England Journal of Medicine | 2002 |
Chronic idiopathic urticaria: a family study
R Asero |
Annals of Allergy Asthma & Immunology | 2002 |
Autoreactivity is highly prevalent in patients with multiple intolerances to NSAIDs
R Asero, A Tedeschi, M Lorini |
Annals of Allergy Asthma & Immunology | 2002 |
Classification of anti-FcϵRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity
RA Sabroe, E Fiebiger, DM Francis, D Maurer, PT Seed, CE Grattan, AK Black, G Stingl, MW Greaves, RM Barr |
Journal of Allergy and Clinical Immunology | 2002 |
TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced late-phase cutaneous reaction
S Ying, Y Kikuchi, Q Meng, AB Kay, AP Kaplan |
Journal of Allergy and Clinical Immunology | 2002 |
A role for C5a in augmenting IgG-dependent histamine release from basophils in chronic urticaria
Y Kikuchi, AP Kaplan |
Journal of Allergy and Clinical Immunology | 2002 |
Evidence for aberrant regulation of the p21Ras pathway in PBMCs of patients with chronic idiopathic urticaria
R Confino-Cohen, D Aharoni, A Goldberg, I Gurevitch, A Buchs, M Weiss, J Weissgarten, MJ Rapoport |
Journal of Allergy and Clinical Immunology | 2002 |
IgE and Anti-IgE Therapy in Asthma and Allergic Disease
D Dombrowicz, A Capron, M Capro |
IgE and Anti-IgE Therapy in Asthma and Allergic Disease: Pathogenesis and Novel Therapeutic Strategies | 2002 |
Autoimmune Urticaria
M Greaves |
Clinical Reviews in Allergy & Immunology | 2002 |
Chronic urticaria: novel clinical and serological aspects
R Asero, A Tedeschi, M Lorini, R Salimbeni, T Zanoletti, A Miadonna |
Clinical & Experimental Allergy | 2001 |
Chronic urticaria: Background, evaluation, and treatment
EN Charlesworth |
Current Allergy and Asthma Reports | 2001 |
Autoimmunity in chronic urticaria and urticarial vasculitis
DC Napoli, TM Freeman |
Current Allergy and Asthma Reports | 2001 |
Multiple drug allergy syndrome: A distinct clinical entity
R Asero |
Current Allergy and Asthma Reports | 2001 |
Methotrexate-responsive chronic idiopathic urticaria: a report of two cases
JE Gach, RA Sabroe, MW Greaves, AK Black |
British Journal of Dermatology | 2001 |
CYCLOSPORIN A IN PATIENTS AFFECTED BY CHRONIC IDIOPATHIC URTICARIA: A THERAPEUTIC ALTERNATIVE
MP Loria, MP Loria, PP Dambra, L D'Oronzio, E Nettis, A Pannofino, E Cavallo, A Ferrannini, A Tursi |
Immunopharmacology and Immunotoxicology | 2001 |
Mechanisms of autoimmune activation of basophils in chronic urticaria
Y Kikuchi, AP Kaplan |
Journal of Allergy and Clinical Immunology | 2001 |
NSAID intolerance in chronic idiopathic urticaria: A study of its relationship with histamine-releasing activity of patients’ sera
R Asero, M Lorini, C Suli, A Tedeschi |
Allergologia et Immunopathologia | 2001 |
Evaluation of chronic urticaria in patients with Hashimoto thyroiditis
A A Kandeel, M Zeid, T Helm, M A Lillie, E Donahue, J L Ambrus Jr |
Journal of Clinical Immunology | 2001 |
Detection of anti-IgE and anti-FceRI alpha chain auto-antibodies in patients with atopic dermatitis
S Hayashi, H Suto, N Wada, H Ogawa, K Okumura, C Ra |
Allergology International | 2000 |
Chronic urticaria
M Greaves |
Journal of Allergy and Clinical Immunology | 2000 |
Urticaria-angioedema and nonurticarial angioedema
R Haydon |
Current Opinion in Otolaryngology & Head and Neck Surgery | 2000 |
Anti-FcεRIα serum autoantibodies in different subtypes of urticaria
T Zuberbier, BM Henz, E Fiebiger, D Maurer, G Stingl |
Allergy | 2000 |
Are IVIG for chronic unremitting urticaria effective?
R Asero |
Allergy | 2000 |
Chronic urticaria in childhood
MW Greaves |
Allergy | 2000 |
Chronic idiopathic urticaria and its management
RA Sabroe, MW Greaves |
Dermatologic Therapy | 2000 |
Effects of complement inactivation and IgG depletion on skin reactivity to autologous serum in chronic idiopathic urticaria
U Fagiolo, F Kricek, C Ruf, A Peserico, A Amadori, M Cancian |
Journal of Allergy and Clinical Immunology | 2000 |
Immunology and inflammation: type I allergy and intolerance
MW Greaves |
Journal of Dermatological Treatment | 2000 |
Human leucocyte antigen class II associations in chronic idiopathic urticaria
BF O'Donnell, CM O'Neill, DM Francis, N Niimi, RM Barr, RJ Barlow, AK Black, KI Welsh, MW Greaves |
British Journal of Dermatology | 1999 |
Recent advances in urticaria, angioedema and related disorders. London, 8-9 April 1999
Sabroe |
Clinical and Experimental Dermatology | 1999 |
Inhibitory effect of heparin on skin reactivity to autologous serum in chronic idiopathic urticaria
U Fagiolo, M Cancian, L Bertollo, A Peserico, A Amadori |
Journal of Allergy and Clinical Immunology | 1999 |
Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: Comparison of patients with and without anti-FcϵRI or anti-IgE autoantibodies
RA Sabroe, E Poon, GE Orchard, D Lane, DM Francis, RM Barr, MM Black, AK Black, MW Greaves |
Journal of Allergy and Clinical Immunology | 1999 |
The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria
SABROE, GRATTAN, FRANCIS, BARR, KOBZA BLACK, GREAVES |
British Journal of Dermatology | 1999 |
THE HIGH-AFFINITY IgE RECEPTOR (FcεRI): From Physiology to Pathology
JP Kinet |
Annual Review of Immunology | 1999 |
The anti-IgE/anti-FcepsilonRIalpha autoantibody network in allergic and autoimmune diseases
MARONE, SPADARO, PALUMBO, CONDORELLI |
Clinical & Experimental Allergy | 1999 |
Chronic idiopathic urticaria: Comparison of the clinical features of patients with and without anti-FcϵRI or anti-IgE autoantibodies
RA Sabroe, PT Seed, DM Francis, RM Barr, AK Black, MW Greaves |
Journal of the American Academy of Dermatology | 1999 |
Human anti-FcepsilonRIalpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid
MP Horn, T Gerster, B Ochensberger, T Derer, F Kricek, MH Jouvin, JP Kinet, T Tschernig, M Vogel, BM Stadler, SM Miescher |
European Journal of Immunology | 1999 |
Immunsystem und Infektiologie
D Ganten, K Ruckpaul |
1999 | |
Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Identification of a structure-function relationship
E Fiebiger, F Hammerschmid, G Stingl, D Maurer |
Journal of Clinical Investigation | 1998 |
Intravenous immunoglobulin in autoimmune chronic urticaria
O'donnell, Barr, Kobza Black, Francis, Kermani, Niimi, Barlow, Winkelmann, Greaves |
British Journal of Dermatology | 1998 |
Most chronic urticaria is food-dependent, and not idiopathic
BM Henz, T Zuberbier |
Experimental Dermatology | 1998 |
Not all chronic urticaria is "idiopathic"
MW Greaves, BF O'Donnell |
Experimental Dermatology | 1998 |
Asthma and Allergic Diseases
WJ Metzger, JA Nyce |
Asthma and Allergic Diseases | 1998 |
Modulation of serum histamine releasing activity in chronic idiopathic urticaria
B Zweiman, M Valenzano, PC Atkins |
Immunopharmacology | 1998 |
Urticaria : causes and treatment
MW Greaves |
Revue Française d'Allergologie et d'Immunologie Clinique | 1998 |
Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity
CE Grattan, D Walpole, DM Francis, N NllMI, G Dootson, S Edler, MF Corbett, RM Barr |
Clinical & Experimental Allergy | 1997 |
Inducible nitric oxide synthase and proinflammatory cytokine expression by human keratinocytes during acute urticaria
PA Bécherel, O Chosidow, LL Goff, C Francès, P Debré, MD Mossalayi, M Arock |
Molecular Medicine | 1997 |
Urticaria, Angioedema, and Autoimmunity
BL Zuraw |
Clinics in Laboratory Medicine | 1997 |
Anti-IgE and anti-FcεRI autoantibodies in clinical allergy
E Fiebiger, G Stingl, D Maurer |
Current Opinion in Immunology | 1996 |
Dermal Mast Cell Activation by Autoantibodies Against the High Affinity IgE Receptor in Chronic Urticaria
N Niimi, DM Francis, F Kermani, BF O'Donnell, M Hide, A Kobza-Black, RK Winkelmann, MW Greaves, RM Barr |
Journal of Investigative Dermatology | 1996 |
Pathophysiology of itching
MW Greaves, PD Wall |
The Lancet | 1996 |
Histamine: The Quintessential Mediator
MW Greaves, RA Sabroe |
The Journal of Dermatology | 1996 |
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