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Citations to this article

Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients?
E Fiebiger, … , J P Kinet, G Stingl
E Fiebiger, … , J P Kinet, G Stingl
Published December 1, 1995
Citation Information: J Clin Invest. 1995;96(6):2606-2612. https://doi.org/10.1172/JCI118325.
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Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients?

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Abstract

While it is well established that acute allergic urticaria is caused by degranulation of skin mast cells occurring after allergen/IgE-dependent cross-linking of high affinity IgE receptors (FcepsilonRI), the pathophysiologic mechanisms operative in chronic urticaria (CU) are less well understood. Some evidence points to the existence of histamine-releasing activity in the serum of CU patients which possibly acts via triggering of FcepsilonRI. In this study, we aimed to better characterize this anti-FcepsilonRIalpha reactivity of CU patients using affinity-purified, IgE-depleted IgG fractions of such individuals (CU-IgG). Using immobilized, recombinant soluble FcepsilonRIalpha as a a reaction target for Western blot studies, we found that 12/32 (37%) CU-IgG serum samples exhibited IgG autoreactivity against FcepsilonRI- alpha. These findings were confirmed by experiments demonstrating that immunoblot-reactive, but not immunoblot-nonreactive, CU-IgG preparations precipitated the FcepsilonRIalpha from FcepsilonRI- alphagamma-transfected cells. No anti-FcepsilonRIalpha reactivity was observed in IgG fractions from atopic dermatitis (AD) patients (0/15) or healthy control individuals (CO:0/15). As opposed to the selective occurrence of IgG anti-Fc epsilon RI alpha autoantibodies in CU patients, IgG anti-IgE antibodies were detected in all groups investigated (CU: 69%; AD: 73%; CO: 26%). While both types of autoantibodies can exhibit histamine-releasing properties, not all of the autoantibodies proved to be functional in vitro. Our results indicate that the occurrence of IgG anti-FcepsilonRIalpha reactivity defines an autoimmune-mediated subentity of CU and provide a basis for the development of new diagnostic procedures and, perhaps, therapeutic strategies for this disease.

Authors

E Fiebiger, D Maurer, H Holub, B Reininger, G Hartmann, M Woisetschläger, J P Kinet, G Stingl

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Citations to this article (215)

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C Tosoni, M Cinquini
International journal of immunopathology and pharmacology 2006
Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria
S Soundararajan, Y Kikuchi, K Joseph, AP Kaplan
Journal of Allergy and Clinical Immunology 2005
The autologous serum skin test in the follow-up of patients with chronic urticaria
A Fusari, C Colangelo, F Bonifazi, L Antonicelli
Allergy 2005
Thyroid autoimmunity in chronic urticaria
BF O'Donnell, DM Francis, GT Swana, PT Seed, AK Black, MW Greaves
British Journal of Dermatology 2005
The thyroid and urticaria
SC Dreskin, KY Andrews
Current Opinion in Allergy and Clinical Immunology 2005
Detection of one VH antibody sequence in both healthy donors and urticaria patients
M Fux, M Vogel, MB Stadler, BM Stadler, SM Miescher
Journal of Immunological Methods 2005
Angioedema
AP Kaplan, MW Greaves
Journal of the American Academy of Dermatology 2005
Urticaria and Angioedema
S Baxi, C Dinakar
Immunology and Allergy Clinics of North America 2005
Dermatologie und Venerologie
O Braun-Falco, G Plewig, HH Wolff, WH Burgdorf, M Landthaler
2005
Autoimmune Diseases of the Skin
M Hertl
2005
A High-Affinity Natural Autoantibody from Human Cord Blood Defines a Physiologically Relevant Epitope on the FcεRIα
T Bobrzynski, M Fux, M Vogel, MB Stadler, BM Stadler, SM Miescher
Journal of immunology (Baltimore, Md. : 1950) 2005
Basophil CD63 expression assay on highly sensitized atopic donor leucocytes-a useful method in chronic autoimmune urticaria
E Gyimesi, S Sipka, K Danko, E Kiss, B Hidvegi, M Gal, J Hunyadi, B Irinyi, A Szegedi
British Journal of Dermatology 2004
Assessment of histamine-releasing activity of sera from patients with chronic urticaria showing positive autologous skin test on human basophils and mast cells
R Asero, M Lorini, SU Chong, T Zuberbier, A Tedeschi
Clinical & Experimental Allergy 2004
Natural anti-FcεRIα autoantibodies may interfere with diagnostic tests for autoimmune urticaria
JM Pachlopnik, MP Horn, M Fux, M Dahinden, M Mandallaz, D Schneeberger, L Baldi, M Vogel, BM Stadler, SM Miescher
Journal of Autoimmunity 2004
Low stimulated IL-4 secretion in PBMC from patients with chronic idiopathic urticaria
R Confino-Cohen, A Goldberg, D Aharoni, L Naiman, A Buchs, M Weiss, J Weissgarten, MJ Rapoport
Cytokine 2004
Hypersensitivity to aspirin: Common eicosanoid alterations in urticaria and asthma
L Mastalerz, M Setkowicz, M Sanak, A Szczeklik
Journal of Allergy and Clinical Immunology 2004
Chronic Urticaria: Aetiology, Management and Current and Future Treatment Options
MM Kozel, RA Sabroe
Drugs 2004
Impact of hydroxychloroquine therapy on chronic urticaria: chronic autoimmune urticaria study and evaluation: Hydroxychloroquine and chronic urticaria
GE Reeves, MJ Boyle, J Bonfield, P Dobson, M Loewenthal
Internal Medicine Journal 2004
Autoreaktive Urtikaria und Autoimmunurtikaria
M Maurer, M Metz, M Magerl, F Siebenhaar, P Staubach
Der Hautarzt 2004
High prevalence of IgG and IgA antibodies to 19-kDa Helicobacter pylori-associated lipoprotein in chronic urticaria
N Bakos, B Fekete, Z Prohaszka, G Fust, L Kalabay
Allergy 2003
Chronic urticaria and autoimmune thyroid disease: is there a link?
M Rottem
Autoimmunity Reviews 2003
Comparison of chronic autoimmune urticaria with chronic idiopathic urticaria
N Bakos, M Hillander
International Journal of Dermatology 2003
Swollen lips and a tender neck
CM Edwards, JJ Cream, J Cassar
Journal of the Royal Society of Medicine 2003
Circulating stem cell factor in patients with chronic idiopathic urticaria
R Asero, A Tedeschi, M Lorini, M Gerosa, P Meroni, P Riboldi
Annals of Allergy Asthma & Immunology 2003
Antithyroid antibodies in chronic urticaria and angioedema
Y Kikuchi, T Fann, AP Kaplan
Journal of Allergy and Clinical Immunology 2003
11. Allergic and immunologic diseases of the skin
A Blauvelt, ST Hwang, MC Udey
Journal of Allergy and Clinical Immunology 2003
Intolerance to nonsteroidal anti-inflammatory drugs might precede by years the onset of chronic urticaria
R Asero
Journal of Allergy and Clinical Immunology 2003
Association of chronic urticaria with thyroid autoimmunity and Raynaud phenomenon with anticentromere antibodies
R Asero, M Lorini, A Tedeschi, CS Carlo
Journal of Allergy and Clinical Immunology 2003
Sex differences in the pathogenesis of chronic urticaria
R Asero
Journal of Allergy and Clinical Immunology 2003
La ciclosporina en el tratamiento de la urticaria crónica idiopática
MR Pibernat, N Fernández-Chico
Piel 2003
Chronic idiopathic urticaria:
MW Greaves
Current Opinion in Allergy and Clinical Immunology 2003
Chronic Urticaria: A Role for Newer Immunomodulatory Drugs?
A Tedeschi, L Airaghi, M Lorini, R Asero
American Journal of Clinical Dermatology 2003
Molecular aspects of allergy
SM Miescher, M Vogel
Molecular Aspects of Medicine 2002
Reactivity to autologous serum skintest and clinical features in chronic idiopathic urticaria
E Nettis, P Dambra, L D'Oronzio, E Cavallo, MP Loria, M Fanelli, A Ferrannini, A Tursi
Clinical and Experimental Dermatology 2002
Increased Expression of Endothelial Cell Adhesion Molecules Due to Mediator Release from Human Foreskin Mast Cells Stimulated by Autoantibodies in Chronic Urticaria Sera
KH Lee, JY Kim, DS Kang, YJ Choi, WJ Lee, JY Ro
Journal of Investigative Dermatology 2002
Chronic Urticaria and Angioedema
AP Kaplan
New England Journal of Medicine 2002
Chronic idiopathic urticaria: a family study
R Asero
Annals of Allergy Asthma & Immunology 2002
Autoreactivity is highly prevalent in patients with multiple intolerances to NSAIDs
R Asero, A Tedeschi, M Lorini
Annals of Allergy Asthma & Immunology 2002
Classification of anti-FcϵRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity
RA Sabroe, E Fiebiger, DM Francis, D Maurer, PT Seed, CE Grattan, AK Black, G Stingl, MW Greaves, RM Barr
Journal of Allergy and Clinical Immunology 2002
TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced late-phase cutaneous reaction
S Ying, Y Kikuchi, Q Meng, AB Kay, AP Kaplan
Journal of Allergy and Clinical Immunology 2002
A role for C5a in augmenting IgG-dependent histamine release from basophils in chronic urticaria
Y Kikuchi, AP Kaplan
Journal of Allergy and Clinical Immunology 2002
Evidence for aberrant regulation of the p21Ras pathway in PBMCs of patients with chronic idiopathic urticaria
R Confino-Cohen, D Aharoni, A Goldberg, I Gurevitch, A Buchs, M Weiss, J Weissgarten, MJ Rapoport
Journal of Allergy and Clinical Immunology 2002
IgE and Anti-IgE Therapy in Asthma and Allergic Disease
D Dombrowicz, A Capron, M Capro
IgE and Anti-IgE Therapy in Asthma and Allergic Disease: Pathogenesis and Novel Therapeutic Strategies 2002
Autoimmune Urticaria
M Greaves
Clinical Reviews in Allergy & Immunology 2002
Chronic urticaria: novel clinical and serological aspects
R Asero, A Tedeschi, M Lorini, R Salimbeni, T Zanoletti, A Miadonna
Clinical & Experimental Allergy 2001
Chronic urticaria: Background, evaluation, and treatment
EN Charlesworth
Current Allergy and Asthma Reports 2001
Autoimmunity in chronic urticaria and urticarial vasculitis
DC Napoli, TM Freeman
Current Allergy and Asthma Reports 2001
Multiple drug allergy syndrome: A distinct clinical entity
R Asero
Current Allergy and Asthma Reports 2001
Methotrexate-responsive chronic idiopathic urticaria: a report of two cases
JE Gach, RA Sabroe, MW Greaves, AK Black
British Journal of Dermatology 2001
CYCLOSPORIN A IN PATIENTS AFFECTED BY CHRONIC IDIOPATHIC URTICARIA: A THERAPEUTIC ALTERNATIVE
MP Loria, MP Loria, PP Dambra, L D'Oronzio, E Nettis, A Pannofino, E Cavallo, A Ferrannini, A Tursi
Immunopharmacology and Immunotoxicology 2001
Mechanisms of autoimmune activation of basophils in chronic urticaria
Y Kikuchi, AP Kaplan
Journal of Allergy and Clinical Immunology 2001
NSAID intolerance in chronic idiopathic urticaria: A study of its relationship with histamine-releasing activity of patients’ sera
R Asero, M Lorini, C Suli, A Tedeschi
Allergologia et Immunopathologia 2001
Evaluation of chronic urticaria in patients with Hashimoto thyroiditis
A A Kandeel, M Zeid, T Helm, M A Lillie, E Donahue, J L Ambrus Jr
Journal of Clinical Immunology 2001
Detection of anti-IgE and anti-FceRI alpha chain auto-antibodies in patients with atopic dermatitis
S Hayashi, H Suto, N Wada, H Ogawa, K Okumura, C Ra
Allergology International 2000
Chronic urticaria
M Greaves
Journal of Allergy and Clinical Immunology 2000
Urticaria-angioedema and nonurticarial angioedema
R Haydon
Current Opinion in Otolaryngology & Head and Neck Surgery 2000
Anti-FcεRIα serum autoantibodies in different subtypes of urticaria
T Zuberbier, BM Henz, E Fiebiger, D Maurer, G Stingl
Allergy 2000
Are IVIG for chronic unremitting urticaria effective?
R Asero
Allergy 2000
Chronic urticaria in childhood
MW Greaves
Allergy 2000
Chronic idiopathic urticaria and its management
RA Sabroe, MW Greaves
Dermatologic Therapy 2000
Effects of complement inactivation and IgG depletion on skin reactivity to autologous serum in chronic idiopathic urticaria
U Fagiolo, F Kricek, C Ruf, A Peserico, A Amadori, M Cancian
Journal of Allergy and Clinical Immunology 2000
Immunology and inflammation: type I allergy and intolerance
MW Greaves
Journal of Dermatological Treatment 2000
Human leucocyte antigen class II associations in chronic idiopathic urticaria
BF O'Donnell, CM O'Neill, DM Francis, N Niimi, RM Barr, RJ Barlow, AK Black, KI Welsh, MW Greaves
British Journal of Dermatology 1999
Recent advances in urticaria, angioedema and related disorders. London, 8-9 April 1999
Sabroe
Clinical and Experimental Dermatology 1999
Inhibitory effect of heparin on skin reactivity to autologous serum in chronic idiopathic urticaria
U Fagiolo, M Cancian, L Bertollo, A Peserico, A Amadori
Journal of Allergy and Clinical Immunology 1999
Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: Comparison of patients with and without anti-FcϵRI or anti-IgE autoantibodies
RA Sabroe, E Poon, GE Orchard, D Lane, DM Francis, RM Barr, MM Black, AK Black, MW Greaves
Journal of Allergy and Clinical Immunology 1999
The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria
SABROE, GRATTAN, FRANCIS, BARR, KOBZA BLACK, GREAVES
British Journal of Dermatology 1999
THE HIGH-AFFINITY IgE RECEPTOR (FcεRI): From Physiology to Pathology
JP Kinet
Annual Review of Immunology 1999
The anti-IgE/anti-FcepsilonRIalpha autoantibody network in allergic and autoimmune diseases
MARONE, SPADARO, PALUMBO, CONDORELLI
Clinical & Experimental Allergy 1999
Chronic idiopathic urticaria: Comparison of the clinical features of patients with and without anti-FcϵRI or anti-IgE autoantibodies
RA Sabroe, PT Seed, DM Francis, RM Barr, AK Black, MW Greaves
Journal of the American Academy of Dermatology 1999
Human anti-FcepsilonRIalpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid
MP Horn, T Gerster, B Ochensberger, T Derer, F Kricek, MH Jouvin, JP Kinet, T Tschernig, M Vogel, BM Stadler, SM Miescher
European Journal of Immunology 1999
Immunsystem und Infektiologie
D Ganten, K Ruckpaul
1999
Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Identification of a structure-function relationship
E Fiebiger, F Hammerschmid, G Stingl, D Maurer
Journal of Clinical Investigation 1998
Intravenous immunoglobulin in autoimmune chronic urticaria
O'donnell, Barr, Kobza Black, Francis, Kermani, Niimi, Barlow, Winkelmann, Greaves
British Journal of Dermatology 1998
Most chronic urticaria is food-dependent, and not idiopathic
BM Henz, T Zuberbier
Experimental Dermatology 1998
Not all chronic urticaria is "idiopathic"
MW Greaves, BF O'Donnell
Experimental Dermatology 1998
Asthma and Allergic Diseases
WJ Metzger, JA Nyce
Asthma and Allergic Diseases 1998
Modulation of serum histamine releasing activity in chronic idiopathic urticaria
B Zweiman, M Valenzano, PC Atkins
Immunopharmacology 1998
Urticaria : causes and treatment
MW Greaves
Revue Française d'Allergologie et d'Immunologie Clinique 1998
Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity
CE Grattan, D Walpole, DM Francis, N NllMI, G Dootson, S Edler, MF Corbett, RM Barr
Clinical & Experimental Allergy 1997
Inducible nitric oxide synthase and proinflammatory cytokine expression by human keratinocytes during acute urticaria
PA Bécherel, O Chosidow, LL Goff, C Francès, P Debré, MD Mossalayi, M Arock
Molecular Medicine 1997
Urticaria, Angioedema, and Autoimmunity
BL Zuraw
Clinics in Laboratory Medicine 1997
Anti-IgE and anti-FcεRI autoantibodies in clinical allergy
E Fiebiger, G Stingl, D Maurer
Current Opinion in Immunology 1996
Dermal Mast Cell Activation by Autoantibodies Against the High Affinity IgE Receptor in Chronic Urticaria
N Niimi, DM Francis, F Kermani, BF O'Donnell, M Hide, A Kobza-Black, RK Winkelmann, MW Greaves, RM Barr
Journal of Investigative Dermatology 1996
Pathophysiology of itching
MW Greaves, PD Wall
The Lancet 1996
Histamine: The Quintessential Mediator
MW Greaves, RA Sabroe
The Journal of Dermatology 1996
Pruritus
J Martin
International Journal of Dermatology 1985
Autoantibodies
MH Lessof, SP Asper
American Heart Journal 1960

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