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Citations to this article

Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty.
M W Chang, … , K Barton, J M Leiden
M W Chang, … , K Barton, J M Leiden
Published November 1, 1995
Citation Information: J Clin Invest. 1995;96(5):2260-2268. https://doi.org/10.1172/JCI118281.
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Adenovirus-mediated over-expression of the cyclin/cyclin-dependent kinase inhibitor, p21 inhibits vascular smooth muscle cell proliferation and neointima formation in the rat carotid artery model of balloon angioplasty.

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Abstract

Vascular smooth muscle cell (VSMC) proliferation after arterial injury is important in the pathogenesis of a number of vascular proliferative disorders, including atherosclerosis and restenosis after balloon angioplasty. Thus, a better understanding of the molecular mechanisms underlying VSMC proliferation in response to arterial injury would have important therapeutic implications for patients with atherosclerotic vascular disease. The p21 protein is a negative regulator of mammalian cell cycle progression that functions both by inhibiting cyclin dependent kinases (CDKs) required for the initiation of S phase, and by binding to and inhibiting the DNA polymerase delta co-factor, proliferating cell nuclear antigen (PCNA). In this report, we show that adenovirus-mediated over-expression of human p21 inhibits growth factor-stimulated VSMC proliferation in vitro by efficiently arresting VSMCs in the G1 phase of the cell cycle. This p21-associated cell cycle arrest is associated both with significant inhibition of the phosphorylation of the retinoblastoma gene product (Rb) and with the formation of complexes between p21 and PCNA in VSMCs. In addition, we demonstrate that localized arterial infection with a p21-encoding adenovirus at the time of balloon angioplasty significantly reduced neointimal hyperplasia in the rat carotid artery model of restenosis. Taken together, these studies demonstrate the important role of p21 in regulating Rb phosphorylation and cell cycle progression in VSMC, and suggest a novel cytostatic gene therapy approach for restenosis and related vascular proliferative disorders.

Authors

M W Chang, E Barr, M M Lu, K Barton, J M Leiden

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Role of Sp1 in the Induction of p27 Gene Expression in Vascular Smooth Muscle Cells In Vitro and After Balloon Angioplasty
V Andrés, J Ureña, E Poch, D Chen, D Goukassian
Arteriosclerosis, thrombosis, and vascular biology 2001
Role for p27 Kip1 in Vascular Smooth Muscle Cell Migration
J Sun, SO Marx, HJ Chen, M Poon, AR Marks, LR Rabbani
Circulation 2001
Improved Adenoviral Vector for Vascular Gene Therapy: Beneficial Effects on Vascular Function and Inflammation
HS Qian, K Channon, V Neplioueva, Q Wang, M Finer, L Tsui, SE George, J McArthur
Circulation research 2001
Tranilast Inhibits Cardiac Allograft Vasculopathy in Association With p21 Waf1/Cip1 Expression on Neointimal Cells in Murine Cardiac Transplantation Model
A Izawa, J Suzuki, W Takahashi, J Amano, M Isobe
Arteriosclerosis, thrombosis, and vascular biology 2001
New Strategies to Prevent Restenosis:
M Kester, P Waybill, M Kozak
American Journal Cardiovascular Drugs 2001
Gen-Medizin
AM Raem, RW Braun, H Fenger, W Michaelis, S Nikol, SF Winter
2001
Gene therapy for restenosis
RC Smith, K Walsh
Current Cardiology Reports 2000
Nitric oxide prevents p2l degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells
MR Kibbe, S Nie, DW Seol, I Kovesdi, A Lizonova, M Makaroun, TR Billiar, E Tzeng
Journal of Vascular Surgery 2000
Gene therapy for cardiovascular diseases
R Brugada, R Roberts
Expert Opinion on Therapeutic Patents 2000
Cardiovascular gene therapy
S Ylä-Herttuala, JF Martin
The Lancet 2000
Targeting hyperproliferative disorders with cyclin dependent kinase inhibitors
GR Rosania, YT Chang
Expert Opinion on Therapeutic Patents 2000
Percutaneous Gene Therapy Using Recombinant Adenoviruses Encoding Human Herpes Simplex Virus Thymidine Kinase, Human PAI-1, and Human NOS3 in Balloon-Injured Porcine Coronary Arteries
O Varenne, P Sinnaeve, H Gillijns, B Iung, V Laurysens, K Meurrens, B Bout, D Valerio, D Colin, SP Janssens, RD Gerard
Human Gene Therapy 2000
PROSPECTS FOR GENETIC THERAPY OF CARDIOVASCULAR DISEASE
HJ Duckers, EG Nabel
Medical Clinics of North America 2000
The mechanisms of coronary restenosis: insights from experimental models
GA Ferns, TY Avades
International Journal of Experimental Pathology 2000
Transplant atherosclerosis
RE Bundy, N Marczin, EF Birks, AH Chester, MH Yacoub
General Pharmacology: The Vascular System 2000
In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model
K Hayashi, S Nakamura, R Morishita, A Moriguchi, M Aoki, K Matsumoto, T Nakamura, Y Kaneda, N Sakai, T Ogihara
Gene Therapy 2000
Effect of p53 gene therapy combined with CTLA4Ig selective immunosuppression on prolonged neointima formation reduction in a rat model
E Ascher, M Scheinman, A Hingorani, P Seth, VK Marella, T Jacob
Annals of Vascular Surgery 2000
Gene delivery from a DNA controlled-release stent in porcine coronary arteries
BD Klugherz, PL Jones, X Cui, W Chen, NF Meneveau, S DeFelice, J Connolly, RL Wilensky, RJ Levy
Nature Biotechnology 2000
Gene therapy for peripheral arterial disease
MJ Mann
Molecular Medicine Today 2000
Biocompatibility of Cardiovascular Gene Delivery Catheters with Adenovirus Vectors: An Important Determinant of the Efficiency of Cardiovascular Gene Transfer
D Marshall
Molecular Therapy 2000
Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
B P Eliceiri, R Paul, P L Schwartzberg, J D Hood, J Leng, D A Cheresh
Molecular Cell 2000
Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer
MO Hiltunen, MP Turunen, M Laitinen, S Ylä-Herttuala
Vascular medicine (London, England) 2000
p21 Waf1/Cip1 Is an Assembly Factor Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Proliferation
RH Weiss, A Joo, C Randour
The Journal of biological chemistry 2000
Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries
L Maillard, EV Belle, FO Tio, A Rivard, M Kearney, D Branellec, PG Steg, JM Isner, K Walsh
Gene Therapy 2000
Antisense and gene therapy to prevent restenosis
A Ehsan, MJ Mann
Vascular medicine (London, England) 2000
Differential Effects of the Cyclin-Dependent Kinase Inhibitors p27 Kip1 , p21 Cip1 , and p16 Ink4 on Vascular Smooth Muscle Cell Proliferation
FC Tanner, M Boehm, LM Akyürek, H San, ZY Yang, J Tashiro, GJ Nabel, EG Nabel
Circulation 2000
Gene Therapy for Restenosis
MR Kibbe, TR Billiar, E Tzeng
Circulation research 2000
Mouse Model of Femoral Artery Denudation Injury Associated With the Rapid Accumulation of Adhesion Molecules on the Luminal Surface and Recruitment of Neutrophils
M Roque, JT Fallon, JJ Badimon, WX Zhang, MB Taubman, ED Reis
Arteriosclerosis, thrombosis, and vascular biology 2000
Gene Therapy for Attenuating Cardiac Allograft Arteriopathy Using Ex Vivo E2F Decoy Transfection by HVJ-AVE–Liposome Method in Mice and Nonhuman Primates
M Kawauchi, J Suzuki, R Morishita, Y Wada, A Izawa, N Tomita, J Amano, Y Kaneda, T Ogihara, S Takamoto, M Isobe
Circulation research 2000
Upregulation and Activation of Stat6 Precede Vascular Smooth Muscle Cell Proliferation in Carotid Artery Injury Model
R Baetta, M Soma, C De-Fraja, C Comparato, C Teruzzi, L Magrassi, E Cattaneo
Arteriosclerosis, thrombosis, and vascular biology 2000
Prevention of restenosis using the gene for cecropin complexed with DOCSPER liposomes under optimized conditions
S Nikol, J Pelisek, MG Engelmann, PH Rolland, S Armeanu
International Journal of Angiology 2000
Monogen bedingte Erbkrankheiten 2
D Ganten, K Ruckpaul
2000
Redox-Mediated Gene Therapies for Environmental Injury: Approaches and Concepts
JF Engelhardt
Antioxidants & Redox Signaling 1999
Gene therapy for atherosclerosis and atherosclerosis-related diseases
T Pakkanen, S Ylä-Herttuala
Current Atherosclerosis Reports 1999
Optimizing Vascular Gene Transfer of Plasminogen Activator Inhibitor 1
MB Deyoung, C Zamarron, AP Lin, C Qiu, RM Driscoll, DA Dichek
Human Gene Therapy 1999
Percutaneous Adenoviral Gene Transfer into Porcine Coronary Arteries: Is Catheter-Based Gene Delivery Adapted to Coronary Circulation?
O Varenne, RD Gerard, P Sinnaeve, H Gillijns, D Collen, S Janssens
Human Gene Therapy 1999
Recommended therapies for restenosis
A Chopra, KL Strzelecki, KD Reese
Expert Opinion on Therapeutic Patents 1999
P53 gene transfer to the injured rat carotid artery promotes apoptosis
M Scheinman, E Ascher, S Kallakuri, A Hingorani, P Gade, M Sherman, P Seth, T Jacob
Surgery 1999
Early Cell Loss after Angioplasty Results in a Disproportionate Decrease in Percutaneous Gene Transfer to the Vessel Wall
A Rivard, Z Luo, H Perlman, JE Fabre, T Nguyen, L Maillard, K Walsh
Human Gene Therapy 1999
The need to introduce gene therapy to the dental curriculum
BJ Baum, BC O'Connell
European Journal of Dental Education 1999
p53 gene transfer to the injured rat carotid artery decreases neointimal formation
M Scheinman, E Ascher, GS Levi, A Hingorani, D Shirazian, P Seth
Journal of Vascular Surgery 1999
Gene Therapy for Cerebrovascular Disease
C Weihl, RL Macdonald, M Stoodley, J L??ders, G Lin
Neurosurgery 1999
The cell cycle and drug discovery: the promise and the hope
G Brooks, NB la Thangue
Drug Discovery Today 1999
Overexpression of p21Waf-1 in Vascular Smooth Muscle Cells: Regulation of Proliferation, Differentiation, and Cell Size
S Kato, M Yamaguchi, T Fujii, N Miyagi, M Terasaki, T Hamada, Y Sugita, M Morimatsu
Experimental and Molecular Pathology 1999
Heart Development
GF Wang, FE Stockdale
Heart Development 1999
Gene Therapy as a Therapeutic Intervention for Vascular Disease:
SL Meyerson, LB Schwartz
The Journal of cardiovascular nursing 1999
Adenovirus-mediated delivery of fas ligand inhibits intimal hyperplasia after balloon injury in immunologically primed animals
Z Luo, M Sata, T Nguyen, JM Kaplan, GY Akita, K Walsh
Circulation 1999
Distinct role of cAMP and cGMP in the cell cycle control of vascular smooth muscle cells: cGMP delays cell cycle transition through suppression of cyclin D1 and cyclin-dependent kinase 4 activation
S Fukumoto, H Koyama, M Hosoi, K Yamakawa, S Tanaka, H Morii, Y Nishizawa
Circulation research 1999
Pulmonary Vascular Gene Transfer: Prospects for Successful Therapy of Pulmonary Hypertension
B Fouty, DM Rodman
American journal of respiratory cell and molecular biology 1999
Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and phosphatidylinositol 3-kinase
F Niculescu, T Badea, H Rus
Atherosclerosis 1999
Glycofection: The Ubiquitous Roles of Sugar Bound on Glycoplexes
V Boutin, A Legrand, R Mayer, M Nachtigal, M Monsigny, P Midoux
Drug Delivery 1999
Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21 Cip1/WAF1
D Chen, K Guo, J Yang, WA Frazier, JM Isner, V Andrés
American journal of physiology. Heart and circulatory physiology 1999
pRB is required for interferon-γ-induction of the MHC class II Aβ gene
X Zhu, S Pattenden, R Bremner
Oncogene 1999
Failure of cdc2 promoter activation and G 2 /M transition by ANG II and AVP in vascular smooth muscle cells
N Fujita, Y Furukawa, N Itabashi, Y Tsuboi, M Matsuda, K Okada, T Saito
American journal of physiology. Heart and circulatory physiology 1999
NOS gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells
RV Sharma, E Tan, S Fang, MV Gurjar, RC Bhalla
American journal of physiology. Heart and circulatory physiology 1999
Design of a muscle cell-specific expression vector utilising human vascular smooth muscle α-actin regulatory elements
MC Keogh, D Chen, JF Schmitt, U Dennehy, VV Kakkar, NR Lemoine
Gene Therapy 1999
Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation
S Nikol, TY Huehns, E Krausz, S Armeanu, MG Engelmann, D Winder, B Salmons, B Hoefling
Gene Therapy 1999
Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation
JQ Tian, A Quaroni
American journal of physiology. Cell physiology 1999
Reversal of GATA-6 Downregulation Promotes Smooth Muscle Differentiation and Inhibits Intimal Hyperplasia in Balloon-Injured Rat Carotid Artery
T Mano, Z Luo, SL Malendowicz, T Evans, K Walsh
Circulation research 1999
Tranilast Inhibits Vascular Smooth Muscle Cell Growth and Intimal Hyperplasia by Induction of p21 waf1/cip1/sdi1 and p53
A Takahashi, T Taniguchi, Y Ishikawa, M Yokoyama
Circulation research 1999
Prevention of Neointimal Formation by a Serine Protease Inhibitor, FUT-175, After Carotid Balloon Injury in Rats
M Sawada, H Yanamoto, I Nagata, N Hashimoto, I Nakahara, Y Akiyama, H Kikuchi
Stroke; a journal of cerebral circulation 1999
Vascular Gene Transfer: From Bench to Bedside
IJ Kullo, RD Simari, RS Schwartz
Arteriosclerosis, thrombosis, and vascular biology 1999
Cellular Effects of β-Particle Delivery on Vascular Smooth Muscle Cells and Endothelial Cells: A Dose-Response Study
J Fareh, R Martel, P Kermani, G Leclerc
Circulation 1999
Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries by Targeting Regulators of the Cell Cycle
R Gallo, A Padurean, T Jayaraman, S Marx, M Roque, S Adelman, J Chesebro, J Fallon, V Fuster, A Marks, JJ Badimon
Circulation 1999
Molecular Cardiology in Clinical Practice
M Sanders, JB Kostis
1999
Adenovirus-Mediated Expression of a Ribozyme to c- myb mRNA Inhibits Smooth Muscle Cell Proliferation and Neointima Formation In Vivo
DG Macejak, H Lin, S Webb, J Chase, K Jensen, TC Jarvis, JM Leiden, L Couture
Journal of virology 1999
Role of c-fos and E2F in the induction of cyclin A transcription and vascular smooth muscle cell proliferation
AM Sylvester, D Chen, K Krasinski, V Andrés
Journal of Clinical Investigation 1998
Effects of Poloxamer 407 on Transfection Time and Percutaneous Adenovirus-Mediated Gene Transfer in Native and Stented Vessels
E Belle, L Maillard, A Rivard, JE Fabre, T Couffinhal, M Kearney, D Branellec, LJ Feldman, K Walsh, JM Isner
Human Gene Therapy 1998
Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions
C Ihling, J Haendeler, G Menzel, RD Hess, G Fraedrich, HE Schaefer, AM Zeiher
The Journal of Pathology 1998
Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo
LL Shears, MR Kibbe, AD Murdock, TR Billiar, A Lizonova, I Kovesdi, SC Watkins, E Tzeng
Journal of the American College of Surgeons 1998
The therapeutic potential of targeting the cell cycle
KR Webster
Expert Opinion on Investigational Drugs 1998
Adenovirus-Mediated Gene Transfer to Lower Limb Artery of Patients with Chronic Critical Leg Ischemia
M Laitinen, K Mäkinen, H Manninen, P Matsi, M Kossila, RS Agrawal, T Pakkanen, JS Luoma, H Viita, J Hartikainen, E Alhava, M Laakso, S Ylä-Herttuala
Human Gene Therapy 1998
Adenoviral Gene Transfer in Arteries of Hypercholesterolemic Nonhuman Primates
DB Schneider, CA Fly, DA Dichek, RL Geary
Human Gene Therapy 1998
Suppression of proliferative cholangitis in a rat model with direct adenovirus-mediated retinoblastoma gene transfer to the biliary tract
R Terao, K Honda, E Hatano, T Uehara, M Yamamoto, Y Yamaoka
Hepatology 1998
Gene therapy for tissue repair and regeneration
J Bonadio, SA Goldstein, RJ Levy
Advanced Drug Delivery Reviews 1998
In vitro growth suppression of vascular smooth muscle cells using adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor
H Yukawa, SI Miyatake, M Saiki, JC Takahashi, T Mima, H Ueno, I Nagata, H Kikuchi, N Hashimoto
Atherosclerosis 1998
Inhibitory effect of photooxidation on intimal and medial thickening of saphenous vein
J Chanda, R Kuribayashi, KX Liu, Y Shibata
The Annals of Thoracic Surgery 1998
Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response
M Sata, H Perlman, DA Muruve, M Silver, M Ikebe, TA Libermann, P Oettgen, K Walsh
Proceedings of the National Academy of Sciences 1998
Advances in Protein Chemistry
CM Silva, J Isgaard, MO Thorner
Advances in Protein Chemistry 1998
Expression of the cyclin-dependent kinase inhibitor, p21Waf-1/Cip-1/Sdi-1, in human vascular smooth muscle cells in the proliferating state
M Yamaguchi, S Kato, T Fujii, N Miyagi, M Morimatsu
Heart and Vessels 1998
Cell cycle progression: new therapeutic target for vascular proliferative disease
RC Braun-Dullaeus, MJ Mann, VJ Dzau
Circulation 1998
Phosphatidylinositol 3-Kinase Inhibitors Block Aortic Smooth Muscle Cell Proliferation in Mid-Late G1 Phase: Effect on Cyclin-Dependent Kinase 2 and the Inhibitory Protein p27KIP1
D Bacqueville, F Casagrande, B Perret, H Chap, JM Darbon, M Breton-Douillon
Biochemical and Biophysical Research Communications 1998
GATA-6 Induces p21 Cip1 Expression and G 1 Cell Cycle Arrest
H Perlman, E Suzuki, M Simonson, RC Smith, K Walsh
The Journal of biological chemistry 1998
Attenuation of ANG II actions by adenovirus delivery of AT 1 receptor antisense in neurons and SMC
D Lu, H Yang, MK Raizada
American journal of physiology. Heart and circulatory physiology 1998
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
Y Kato, RI Tapping, S Huang, MH Watson, RJ Ulevitch, JD Lee
Nature 1998
Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function
GJ Christ, J Rehman, N Day, L Salkoff, M Valcic, A Melman, J Geliebter
American journal of physiology. Heart and circulatory physiology 1998
Local Adenovirus-Mediated Transfer of Human Endothelial Nitric Oxide Synthase Reduces Luminal Narrowing After Coronary Angioplasty in Pigs
O Varenne, S Pislaru, H Gillijns, NV Pelt, RD Gerard, P Zoldhelyi, FV de Werf, D Collen, SP Janssens
Circulation 1998
Gene Therapy for Restenosis: Are We Ready?
MB DeYoung, DA Dichek
Circulation research 1998
PDGF-Receptor Tyrosine Kinase Blocker AG1295 Selectively Attenuates Smooth Muscle Cell Growth In Vitro and Reduces Neointimal Formation After Balloon Angioplasty in Swine
S Banai, Y Wolf, G Golomb, A Pearle, J Waltenberger, I Fishbein, A Schneider, A Gazit, L Perez, R Huber, G Lazarovichi, L Rabinovich, A Levitzki, SD Gertz
Circulation 1998
Inhibition of Growth of Human Vascular Smooth Muscle Cells by Overexpression of p21 Gene Through Induction of Apoptosis
H Matsushita, R Morishita, I Kida, M Aoki, S Hayashi, N Tomita, K Yamamoto, A Moriguchi, A Noda, Y Kaneda, J Higaki, T Ogihara
Hypertension 1998
Gene Therapy for Restenosis: Getting Nearer the Heart of the Matter
S Baek, KL March
Circulation research 1998
Transfer of Wild-Type p53 Gene Effectively Inhibits Vascular Smooth Muscle Cell Proliferation In Vitro and In Vivo
Y Yonemitsu, Y Kaneda, S Tanaka, Y Nakashima, K Komori, K Sugimachi, K Sueishi
Circulation research 1998
Expression of Cyclin-Dependent Kinase Inhibitors in Vascular Disease
FC Tanner, ZY Yang, E Duckers, D Gordon, GJ Nabel, EG Nabel
Circulation research 1998
Herz-Kreislauf-Erkrankungen
D Ganten, K Ruckpaul
1998
Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
D Chen, K Krasinski, A Sylvester, J Chen, PD Nisen, V Andrés
Journal of Clinical Investigation 1997
Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo
S Kim, H Lin, E Barr, L Chu, JM Leiden, MS Parmacek
Journal of Clinical Investigation 1997
Atherosclerosis and arteriosclerosis in chronic renal failure
GM London, TB Drueke
Kidney International 1997
Passivation of Metallic Stents After Arterial Gene Transfer of phVEGF165 Inhibits Thrombus Formation and Intimal Thickening
EV Belle, FO Tio, D Chen, L Maillard, D Chen, M Kearney, JM Isner
Journal of the American College of Cardiology 1997
Gene and other biological therapies for vascular diseases
D Stephan, EG Nabel
Fundamental & Clinical Pharmacology 1997
Gene-based therapies for restenosis
V Labhasetwar, B Chen, DW Muller, J Bonadio, K Ciftci, K March, RJ Levy
Advanced Drug Delivery Reviews 1997
In Vivo Gene Transfer: A Biological Tool
EG Nabel, R Simari, Z Yang, H San, GJ Nabel
Annals of the New York Academy of Sciences 1997
Gene Therapy for Hepatic and Vascular Disorders
KP Ponder, JR Duncan, ME Hicks
Journal of Vascular and Interventional Radiology 1997
Prospects for intravascular gene therapy
RC Smith, K Walsh
Journal of Clinical Apheresis 1997
Cell-cycle control and renal disease
SJ Shankland
Kidney International 1997
Inhibition of smooth muscle cell migration by the p21 cyclin-dependent kinase inhibitor (Cip1)
R Fukui
Atherosclerosis 1997
Delivery of tumor suppressor genes to reverse the malignant phenotype
NW Gibson, SP Kennedy
Advanced Drug Delivery Reviews 1997
Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b
S Huang, Y Jiang, Z Li, E Nishida, P Mathias, S Lin, RJ Ulevitch, GR Nemerow, J Han
Immunity 1997
Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21
A Morozov, P Shiyanov, E Barr, JM Leiden, P Raychaudhuri
Journal of virology 1997
Adenovirus-mediated gene transfer: biological and clinical applications
S Denger, J Kreuzer
Fibrinolysis and Proteolysis 1997
Antithrombotic gene therapy
RD Gerard
Fibrinolysis and Proteolysis 1997
Gene Therapy for Vascular Disease
LB Schwartz, J Moawad
Annals of Vascular Surgery 1997
Future horizons in cardiovascular molecular therapeutics
V J Dzau, G H Gibbons, M Mann, R Braun-Dullaeus
The American Journal of Cardiology 1997
Adenovirus gene therapy for hypercholesterolemia, thrombosis and restenosis
RD Gerard, D Collen
Cardiovascular Research 1997
Induction of the Cyclin-dependent Kinase Inhibitor p21 Sdi1/Cip1/Waf1 by Nitric Oxide-generating Vasodilator in Vascular Smooth Muscle Cells
A Ishida, T Sasaguri, C Kosaka, H Nojima, J Ogata
The Journal of biological chemistry 1997
Inhcer of β-Interferon
D Stephan, H San, Z Yang, D Gordon, S Goelz, GJ Nabel, EG Nabel
Molecular Medicine 1997
Adenovirus-Mediated Transfer of a Dominant-Negative H- ras Suppresses Neointimal Formation in Balloon-Injured Arteries In Vivo
H Ueno, H Yamamoto, S Ito, JJ Li, A Takeshita
Arteriosclerosis, thrombosis, and vascular biology 1997
Modulation of Growth Factor Action: Implications for the Treatment of Cardiovascular Diseases
J Waltenberger
Circulation 1997
Adenovirus-Mediated Expression of the Secreted Form of Basic Fibroblast Growth Factor (FGF-2) Induces Cellular Proliferation and Angiogenesis In Vivo
H Ueno, JJ Li, S Masuda, Z Qi, H Yamamoto, A Takeshita
Arteriosclerosis, thrombosis, and vascular biology 1997
Augmented Adenovirus-Mediated Gene Transfer to Atherosclerotic Vessels
H Ooboshi, CD Rios, Y Chu, SD Christenson, FM Faraci, BL Davidson, DD Heistad
Arteriosclerosis, thrombosis, and vascular biology 1997
Local Expression of C-Type Natriuretic Peptide Markedly Suppresses Neointimal Formation in Rat Injured Arteries Through an Autocrine/Paracrine Loop
H Ueno, A Haruno, N Morisaki, M Furuya, K Kangawa, A Takeshita, Y Saito
Circulation 1997
Downregulation of Cyclin G1 Expression by Retrovirus-Mediated Antisense Gene Transfer Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation
NL Zhu, L Wu, PX Liu, EM Gordon, WF Anderson, VA Starnes, FL Hall
Circulation 1997
Temporally and Spatially Coordinated Expression of Cell Cycle Regulatory Factors After Angioplasty
GL Wei, K Krasinski, M Kearney, JM Isner, K Walsh, V Andres
Circulation research 1997
Inhibition of Vascular Smooth Muscle Cell Proliferation and Neointimal Accumulation by Adenovirus-Mediated Gene Transfer of Cytosine Deaminase
RL Harrell, MA Rajanayagam, AM Doanes, RJ Guzman, EA Hirschowitz, RG Crystal, SE Epstein, T Finkel
Circulation 1997
Arterial Remodeling: A Critical Factor in Restenosis
A Lafont, EJ Topol
1997
Novel Methods in Molecular and Cellular Biochemistry of Muscle
GN Pierce, WC Claycomb
1997
p53 expression induces apoptosis in hippocampal pyramidal neuron cultures
J Jordán, M F Galindo, J H Prehn, R R Weichselbaum, M Beckett, G D Ghadge, R P Roos, J M Leiden, R J Miller
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
Novel methods for adenovirus-mediated gene transfer to blood vessels in vivo
H Ooboshi, C D Ríos, D D Heistad
Molecular and Cellular Biochemistry 1997
p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures
Jordán J, Galindo MF, Prehn JH, Weichselbaum RR, Beckett M, Ghadge GD, Roos RP, Leiden JM, Miller RJ
Journal of Neuroscience 1997
Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
R E Law, W P Meehan, X P Xi, K Graf, D A Wuthrich, W Coats, D Faxon, W A Hsueh
Journal of Clinical Investigation 1996
Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis
JW Pippin, Q Qu, L Meijer, SJ Shankland
Journal of Clinical Investigation 1996
Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis
JW Pippin, Q Qu, L Meijer, SJ Shankland
Kidney International 1996
Molecular biology and post-angioplasty restenosis
S Nikol, TY Huehns, B Höfling
Atherosclerosis 1996
Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury
ZY Yang, RD Simari, ND Perkins, H San, D Gordon, GJ Nabel, EG Nabel
Proceedings of the National Academy of Sciences 1996
Reactive oxygen species are downstream mediators of p53-dependent apoptosis
TM Johnson, ZX Yu, VJ Ferrans, RA Lowenstein, T Finkel
Proceedings of the National Academy of Sciences 1996
Molecular Therapies for Vascular Diseases
GH Gibbons, VJ Dzau
Science 1996
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal
Advances in Pharmacology 1994

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