Vascular smooth muscle cell (VSMC) proliferation after arterial injury is important in the pathogenesis of a number of vascular proliferative disorders, including atherosclerosis and restenosis after balloon angioplasty. Thus, a better understanding of the molecular mechanisms underlying VSMC proliferation in response to arterial injury would have important therapeutic implications for patients with atherosclerotic vascular disease. The p21 protein is a negative regulator of mammalian cell cycle progression that functions both by inhibiting cyclin dependent kinases (CDKs) required for the initiation of S phase, and by binding to and inhibiting the DNA polymerase delta co-factor, proliferating cell nuclear antigen (PCNA). In this report, we show that adenovirus-mediated over-expression of human p21 inhibits growth factor-stimulated VSMC proliferation in vitro by efficiently arresting VSMCs in the G1 phase of the cell cycle. This p21-associated cell cycle arrest is associated both with significant inhibition of the phosphorylation of the retinoblastoma gene product (Rb) and with the formation of complexes between p21 and PCNA in VSMCs. In addition, we demonstrate that localized arterial infection with a p21-encoding adenovirus at the time of balloon angioplasty significantly reduced neointimal hyperplasia in the rat carotid artery model of restenosis. Taken together, these studies demonstrate the important role of p21 in regulating Rb phosphorylation and cell cycle progression in VSMC, and suggest a novel cytostatic gene therapy approach for restenosis and related vascular proliferative disorders.
M W Chang, E Barr, M M Lu, K Barton, J M Leiden
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GR Rosania, YT Chang |
Expert Opinion on Therapeutic Patents | 2000 |
Percutaneous Gene Therapy Using Recombinant Adenoviruses Encoding Human Herpes Simplex Virus Thymidine Kinase, Human PAI-1, and Human NOS3 in Balloon-Injured Porcine Coronary Arteries
O Varenne, P Sinnaeve, H Gillijns, B Iung, V Laurysens, K Meurrens, B Bout, D Valerio, D Colin, SP Janssens, RD Gerard |
Human Gene Therapy | 2000 |
PROSPECTS FOR GENETIC THERAPY OF CARDIOVASCULAR DISEASE
HJ Duckers, EG Nabel |
Medical Clinics of North America | 2000 |
The mechanisms of coronary restenosis: insights from experimental models
GA Ferns, TY Avades |
International Journal of Experimental Pathology | 2000 |
Transplant atherosclerosis
RE Bundy, N Marczin, EF Birks, AH Chester, MH Yacoub |
General Pharmacology: The Vascular System | 2000 |
In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model
K Hayashi, S Nakamura, R Morishita, A Moriguchi, M Aoki, K Matsumoto, T Nakamura, Y Kaneda, N Sakai, T Ogihara |
Gene Therapy | 2000 |
Effect of p53 gene therapy combined with CTLA4Ig selective immunosuppression on prolonged neointima formation reduction in a rat model
E Ascher, M Scheinman, A Hingorani, P Seth, VK Marella, T Jacob |
Annals of Vascular Surgery | 2000 |
Gene delivery from a DNA controlled-release stent in porcine coronary arteries
BD Klugherz, PL Jones, X Cui, W Chen, NF Meneveau, S DeFelice, J Connolly, RL Wilensky, RJ Levy |
Nature Biotechnology | 2000 |
Gene therapy for peripheral arterial disease
MJ Mann |
Molecular Medicine Today | 2000 |
Biocompatibility of Cardiovascular Gene Delivery Catheters with Adenovirus Vectors: An Important Determinant of the Efficiency of Cardiovascular Gene Transfer
D Marshall |
Molecular Therapy | 2000 |
Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
B P Eliceiri, R Paul, P L Schwartzberg, J D Hood, J Leng, D A Cheresh |
Molecular Cell | 2000 |
Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer
MO Hiltunen, MP Turunen, M Laitinen, S Ylä-Herttuala |
Vascular medicine (London, England) | 2000 |
p21 Waf1/Cip1 Is an Assembly Factor Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Proliferation
RH Weiss, A Joo, C Randour |
The Journal of biological chemistry | 2000 |
Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries
L Maillard, EV Belle, FO Tio, A Rivard, M Kearney, D Branellec, PG Steg, JM Isner, K Walsh |
Gene Therapy | 2000 |
Antisense and gene therapy to prevent restenosis
A Ehsan, MJ Mann |
Vascular medicine (London, England) | 2000 |
Differential Effects of the Cyclin-Dependent Kinase Inhibitors p27 Kip1 , p21 Cip1 , and p16 Ink4 on Vascular Smooth Muscle Cell Proliferation
FC Tanner, M Boehm, LM Akyürek, H San, ZY Yang, J Tashiro, GJ Nabel, EG Nabel |
Circulation | 2000 |
Gene Therapy for Restenosis
MR Kibbe, TR Billiar, E Tzeng |
Circulation research | 2000 |
Mouse Model of Femoral Artery Denudation Injury Associated With the Rapid Accumulation of Adhesion Molecules on the Luminal Surface and Recruitment of Neutrophils
M Roque, JT Fallon, JJ Badimon, WX Zhang, MB Taubman, ED Reis |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Gene Therapy for Attenuating Cardiac Allograft Arteriopathy Using Ex Vivo E2F Decoy Transfection by HVJ-AVE–Liposome Method in Mice and Nonhuman Primates
M Kawauchi, J Suzuki, R Morishita, Y Wada, A Izawa, N Tomita, J Amano, Y Kaneda, T Ogihara, S Takamoto, M Isobe |
Circulation research | 2000 |
Upregulation and Activation of Stat6 Precede Vascular Smooth Muscle Cell Proliferation in Carotid Artery Injury Model
R Baetta, M Soma, C De-Fraja, C Comparato, C Teruzzi, L Magrassi, E Cattaneo |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Prevention of restenosis using the gene for cecropin complexed with DOCSPER liposomes under optimized conditions
S Nikol, J Pelisek, MG Engelmann, PH Rolland, S Armeanu |
International Journal of Angiology | 2000 |
Monogen bedingte Erbkrankheiten 2
D Ganten, K Ruckpaul |
2000 | |
Redox-Mediated Gene Therapies for Environmental Injury: Approaches and Concepts
JF Engelhardt |
Antioxidants & Redox Signaling | 1999 |
Gene therapy for atherosclerosis and atherosclerosis-related diseases
T Pakkanen, S Ylä-Herttuala |
Current Atherosclerosis Reports | 1999 |
Optimizing Vascular Gene Transfer of Plasminogen Activator Inhibitor 1
MB Deyoung, C Zamarron, AP Lin, C Qiu, RM Driscoll, DA Dichek |
Human Gene Therapy | 1999 |
Percutaneous Adenoviral Gene Transfer into Porcine Coronary Arteries: Is Catheter-Based Gene Delivery Adapted to Coronary Circulation?
O Varenne, RD Gerard, P Sinnaeve, H Gillijns, D Collen, S Janssens |
Human Gene Therapy | 1999 |
Recommended therapies for restenosis
A Chopra, KL Strzelecki, KD Reese |
Expert Opinion on Therapeutic Patents | 1999 |
P53 gene transfer to the injured rat carotid artery promotes apoptosis
M Scheinman, E Ascher, S Kallakuri, A Hingorani, P Gade, M Sherman, P Seth, T Jacob |
Surgery | 1999 |
Early Cell Loss after Angioplasty Results in a Disproportionate Decrease in Percutaneous Gene Transfer to the Vessel Wall
A Rivard, Z Luo, H Perlman, JE Fabre, T Nguyen, L Maillard, K Walsh |
Human Gene Therapy | 1999 |
The need to introduce gene therapy to the dental curriculum
BJ Baum, BC O'Connell |
European Journal of Dental Education | 1999 |
p53 gene transfer to the injured rat carotid artery decreases neointimal formation
M Scheinman, E Ascher, GS Levi, A Hingorani, D Shirazian, P Seth |
Journal of Vascular Surgery | 1999 |
Gene Therapy for Cerebrovascular Disease
C Weihl, RL Macdonald, M Stoodley, J L??ders, G Lin |
Neurosurgery | 1999 |
The cell cycle and drug discovery: the promise and the hope
G Brooks, NB la Thangue |
Drug Discovery Today | 1999 |
Overexpression of p21Waf-1 in Vascular Smooth Muscle Cells: Regulation of Proliferation, Differentiation, and Cell Size
S Kato, M Yamaguchi, T Fujii, N Miyagi, M Terasaki, T Hamada, Y Sugita, M Morimatsu |
Experimental and Molecular Pathology | 1999 |
Heart Development
GF Wang, FE Stockdale |
Heart Development | 1999 |
Gene Therapy as a Therapeutic Intervention for Vascular Disease:
SL Meyerson, LB Schwartz |
The Journal of cardiovascular nursing | 1999 |
Adenovirus-mediated delivery of fas ligand inhibits intimal hyperplasia after balloon injury in immunologically primed animals
Z Luo, M Sata, T Nguyen, JM Kaplan, GY Akita, K Walsh |
Circulation | 1999 |
Distinct role of cAMP and cGMP in the cell cycle control of vascular smooth muscle cells: cGMP delays cell cycle transition through suppression of cyclin D1 and cyclin-dependent kinase 4 activation
S Fukumoto, H Koyama, M Hosoi, K Yamakawa, S Tanaka, H Morii, Y Nishizawa |
Circulation research | 1999 |
Pulmonary Vascular Gene Transfer: Prospects for Successful Therapy of Pulmonary Hypertension
B Fouty, DM Rodman |
American journal of respiratory cell and molecular biology | 1999 |
Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and phosphatidylinositol 3-kinase
F Niculescu, T Badea, H Rus |
Atherosclerosis | 1999 |
Glycofection: The Ubiquitous Roles of Sugar Bound on Glycoplexes
V Boutin, A Legrand, R Mayer, M Nachtigal, M Monsigny, P Midoux |
Drug Delivery | 1999 |
Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21 Cip1/WAF1
D Chen, K Guo, J Yang, WA Frazier, JM Isner, V Andrés |
American journal of physiology. Heart and circulatory physiology | 1999 |
pRB is required for interferon-γ-induction of the MHC class II Aβ gene
X Zhu, S Pattenden, R Bremner |
Oncogene | 1999 |
Failure of cdc2 promoter activation and G 2 /M transition by ANG II and AVP in vascular smooth muscle cells
N Fujita, Y Furukawa, N Itabashi, Y Tsuboi, M Matsuda, K Okada, T Saito |
American journal of physiology. Heart and circulatory physiology | 1999 |
NOS gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells
RV Sharma, E Tan, S Fang, MV Gurjar, RC Bhalla |
American journal of physiology. Heart and circulatory physiology | 1999 |
Design of a muscle cell-specific expression vector utilising human vascular smooth muscle α-actin regulatory elements
MC Keogh, D Chen, JF Schmitt, U Dennehy, VV Kakkar, NR Lemoine |
Gene Therapy | 1999 |
Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation
S Nikol, TY Huehns, E Krausz, S Armeanu, MG Engelmann, D Winder, B Salmons, B Hoefling |
Gene Therapy | 1999 |
Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation
JQ Tian, A Quaroni |
American journal of physiology. Cell physiology | 1999 |
Reversal of GATA-6 Downregulation Promotes Smooth Muscle Differentiation and Inhibits Intimal Hyperplasia in Balloon-Injured Rat Carotid Artery
T Mano, Z Luo, SL Malendowicz, T Evans, K Walsh |
Circulation research | 1999 |
Tranilast Inhibits Vascular Smooth Muscle Cell Growth and Intimal Hyperplasia by Induction of p21 waf1/cip1/sdi1 and p53
A Takahashi, T Taniguchi, Y Ishikawa, M Yokoyama |
Circulation research | 1999 |
Prevention of Neointimal Formation by a Serine Protease Inhibitor, FUT-175, After Carotid Balloon Injury in Rats
M Sawada, H Yanamoto, I Nagata, N Hashimoto, I Nakahara, Y Akiyama, H Kikuchi |
Stroke; a journal of cerebral circulation | 1999 |
Vascular Gene Transfer: From Bench to Bedside
IJ Kullo, RD Simari, RS Schwartz |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Cellular Effects of β-Particle Delivery on Vascular Smooth Muscle Cells and Endothelial Cells: A Dose-Response Study
J Fareh, R Martel, P Kermani, G Leclerc |
Circulation | 1999 |
Inhibition of Intimal Thickening After Balloon Angioplasty in Porcine Coronary Arteries by Targeting Regulators of the Cell Cycle
R Gallo, A Padurean, T Jayaraman, S Marx, M Roque, S Adelman, J Chesebro, J Fallon, V Fuster, A Marks, JJ Badimon |
Circulation | 1999 |
Molecular Cardiology in Clinical Practice
M Sanders, JB Kostis |
1999 | |
Adenovirus-Mediated Expression of a Ribozyme to c- myb mRNA Inhibits Smooth Muscle Cell Proliferation and Neointima Formation In Vivo
DG Macejak, H Lin, S Webb, J Chase, K Jensen, TC Jarvis, JM Leiden, L Couture |
Journal of virology | 1999 |
Role of c-fos and E2F in the induction of cyclin A transcription and vascular smooth muscle cell proliferation
AM Sylvester, D Chen, K Krasinski, V Andrés |
Journal of Clinical Investigation | 1998 |
Effects of Poloxamer 407 on Transfection Time and Percutaneous Adenovirus-Mediated Gene Transfer in Native and Stented Vessels
E Belle, L Maillard, A Rivard, JE Fabre, T Couffinhal, M Kearney, D Branellec, LJ Feldman, K Walsh, JM Isner |
Human Gene Therapy | 1998 |
Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions
C Ihling, J Haendeler, G Menzel, RD Hess, G Fraedrich, HE Schaefer, AM Zeiher |
The Journal of Pathology | 1998 |
Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo
LL Shears, MR Kibbe, AD Murdock, TR Billiar, A Lizonova, I Kovesdi, SC Watkins, E Tzeng |
Journal of the American College of Surgeons | 1998 |
The therapeutic potential of targeting the cell cycle
KR Webster |
Expert Opinion on Investigational Drugs | 1998 |
Adenovirus-Mediated Gene Transfer to Lower Limb Artery of Patients with Chronic Critical Leg Ischemia
M Laitinen, K Mäkinen, H Manninen, P Matsi, M Kossila, RS Agrawal, T Pakkanen, JS Luoma, H Viita, J Hartikainen, E Alhava, M Laakso, S Ylä-Herttuala |
Human Gene Therapy | 1998 |
Adenoviral Gene Transfer in Arteries of Hypercholesterolemic Nonhuman Primates
DB Schneider, CA Fly, DA Dichek, RL Geary |
Human Gene Therapy | 1998 |
Suppression of proliferative cholangitis in a rat model with direct adenovirus-mediated retinoblastoma gene transfer to the biliary tract
R Terao, K Honda, E Hatano, T Uehara, M Yamamoto, Y Yamaoka |
Hepatology | 1998 |
Gene therapy for tissue repair and regeneration
J Bonadio, SA Goldstein, RJ Levy |
Advanced Drug Delivery Reviews | 1998 |
In vitro growth suppression of vascular smooth muscle cells using adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor
H Yukawa, SI Miyatake, M Saiki, JC Takahashi, T Mima, H Ueno, I Nagata, H Kikuchi, N Hashimoto |
Atherosclerosis | 1998 |
Inhibitory effect of photooxidation on intimal and medial thickening of saphenous vein
J Chanda, R Kuribayashi, KX Liu, Y Shibata |
The Annals of Thoracic Surgery | 1998 |
Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response
M Sata, H Perlman, DA Muruve, M Silver, M Ikebe, TA Libermann, P Oettgen, K Walsh |
Proceedings of the National Academy of Sciences | 1998 |
Advances in Protein Chemistry
CM Silva, J Isgaard, MO Thorner |
Advances in Protein Chemistry | 1998 |
Expression of the cyclin-dependent kinase inhibitor, p21Waf-1/Cip-1/Sdi-1, in human vascular smooth muscle cells in the proliferating state
M Yamaguchi, S Kato, T Fujii, N Miyagi, M Morimatsu |
Heart and Vessels | 1998 |
Cell cycle progression: new therapeutic target for vascular proliferative disease
RC Braun-Dullaeus, MJ Mann, VJ Dzau |
Circulation | 1998 |
Phosphatidylinositol 3-Kinase Inhibitors Block Aortic Smooth Muscle Cell Proliferation in Mid-Late G1 Phase: Effect on Cyclin-Dependent Kinase 2 and the Inhibitory Protein p27KIP1
D Bacqueville, F Casagrande, B Perret, H Chap, JM Darbon, M Breton-Douillon |
Biochemical and Biophysical Research Communications | 1998 |
GATA-6 Induces p21 Cip1 Expression and G 1 Cell Cycle Arrest
H Perlman, E Suzuki, M Simonson, RC Smith, K Walsh |
The Journal of biological chemistry | 1998 |
Attenuation of ANG II actions by adenovirus delivery of AT 1 receptor antisense in neurons and SMC
D Lu, H Yang, MK Raizada |
American journal of physiology. Heart and circulatory physiology | 1998 |
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
Y Kato, RI Tapping, S Huang, MH Watson, RJ Ulevitch, JD Lee |
Nature | 1998 |
Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function
GJ Christ, J Rehman, N Day, L Salkoff, M Valcic, A Melman, J Geliebter |
American journal of physiology. Heart and circulatory physiology | 1998 |
Local Adenovirus-Mediated Transfer of Human Endothelial Nitric Oxide Synthase Reduces Luminal Narrowing After Coronary Angioplasty in Pigs
O Varenne, S Pislaru, H Gillijns, NV Pelt, RD Gerard, P Zoldhelyi, FV de Werf, D Collen, SP Janssens |
Circulation | 1998 |
Gene Therapy for Restenosis: Are We Ready?
MB DeYoung, DA Dichek |
Circulation research | 1998 |
PDGF-Receptor Tyrosine Kinase Blocker AG1295 Selectively Attenuates Smooth Muscle Cell Growth In Vitro and Reduces Neointimal Formation After Balloon Angioplasty in Swine
S Banai, Y Wolf, G Golomb, A Pearle, J Waltenberger, I Fishbein, A Schneider, A Gazit, L Perez, R Huber, G Lazarovichi, L Rabinovich, A Levitzki, SD Gertz |
Circulation | 1998 |
Inhibition of Growth of Human Vascular Smooth Muscle Cells by Overexpression of p21 Gene Through Induction of Apoptosis
H Matsushita, R Morishita, I Kida, M Aoki, S Hayashi, N Tomita, K Yamamoto, A Moriguchi, A Noda, Y Kaneda, J Higaki, T Ogihara |
Hypertension | 1998 |
Gene Therapy for Restenosis: Getting Nearer the Heart of the Matter
S Baek, KL March |
Circulation research | 1998 |
Transfer of Wild-Type p53 Gene Effectively Inhibits Vascular Smooth Muscle Cell Proliferation In Vitro and In Vivo
Y Yonemitsu, Y Kaneda, S Tanaka, Y Nakashima, K Komori, K Sugimachi, K Sueishi |
Circulation research | 1998 |
Expression of Cyclin-Dependent Kinase Inhibitors in Vascular Disease
FC Tanner, ZY Yang, E Duckers, D Gordon, GJ Nabel, EG Nabel |
Circulation research | 1998 |
Herz-Kreislauf-Erkrankungen
D Ganten, K Ruckpaul |
1998 | |
Downregulation of cyclin-dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
D Chen, K Krasinski, A Sylvester, J Chen, PD Nisen, V Andrés |
Journal of Clinical Investigation | 1997 |
Transcriptional targeting of replication-defective adenovirus transgene expression to smooth muscle cells in vivo
S Kim, H Lin, E Barr, L Chu, JM Leiden, MS Parmacek |
Journal of Clinical Investigation | 1997 |
Atherosclerosis and arteriosclerosis in chronic renal failure
GM London, TB Drueke |
Kidney International | 1997 |
Passivation of Metallic Stents After Arterial Gene Transfer of phVEGF165 Inhibits Thrombus Formation and Intimal Thickening
EV Belle, FO Tio, D Chen, L Maillard, D Chen, M Kearney, JM Isner |
Journal of the American College of Cardiology | 1997 |
Gene and other biological therapies for vascular diseases
D Stephan, EG Nabel |
Fundamental & Clinical Pharmacology | 1997 |
Gene-based therapies for restenosis
V Labhasetwar, B Chen, DW Muller, J Bonadio, K Ciftci, K March, RJ Levy |
Advanced Drug Delivery Reviews | 1997 |
In Vivo Gene Transfer: A Biological Tool
EG Nabel, R Simari, Z Yang, H San, GJ Nabel |
Annals of the New York Academy of Sciences | 1997 |
Gene Therapy for Hepatic and Vascular Disorders
KP Ponder, JR Duncan, ME Hicks |
Journal of Vascular and Interventional Radiology | 1997 |
Prospects for intravascular gene therapy
RC Smith, K Walsh |
Journal of Clinical Apheresis | 1997 |
Cell-cycle control and renal disease
SJ Shankland |
Kidney International | 1997 |
Inhibition of smooth muscle cell migration by the p21 cyclin-dependent kinase inhibitor (Cip1)
R Fukui |
Atherosclerosis | 1997 |
Delivery of tumor suppressor genes to reverse the malignant phenotype
NW Gibson, SP Kennedy |
Advanced Drug Delivery Reviews | 1997 |
Apoptosis Signaling Pathway in T Cells Is Composed of ICE/Ced-3 Family Proteases and MAP Kinase Kinase 6b
S Huang, Y Jiang, Z Li, E Nishida, P Mathias, S Lin, RJ Ulevitch, GR Nemerow, J Han |
Immunity | 1997 |
Accumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21
A Morozov, P Shiyanov, E Barr, JM Leiden, P Raychaudhuri |
Journal of virology | 1997 |
Adenovirus-mediated gene transfer: biological and clinical applications
S Denger, J Kreuzer |
Fibrinolysis and Proteolysis | 1997 |
Antithrombotic gene therapy
RD Gerard |
Fibrinolysis and Proteolysis | 1997 |
Gene Therapy for Vascular Disease
LB Schwartz, J Moawad |
Annals of Vascular Surgery | 1997 |
Future horizons in cardiovascular molecular therapeutics
V J Dzau, G H Gibbons, M Mann, R Braun-Dullaeus |
The American Journal of Cardiology | 1997 |
Adenovirus gene therapy for hypercholesterolemia, thrombosis and restenosis
RD Gerard, D Collen |
Cardiovascular Research | 1997 |
Induction of the Cyclin-dependent Kinase Inhibitor p21 Sdi1/Cip1/Waf1 by Nitric Oxide-generating Vasodilator in Vascular Smooth Muscle Cells
A Ishida, T Sasaguri, C Kosaka, H Nojima, J Ogata |
The Journal of biological chemistry | 1997 |
Inhcer of β-Interferon
D Stephan, H San, Z Yang, D Gordon, S Goelz, GJ Nabel, EG Nabel |
Molecular Medicine | 1997 |
Adenovirus-Mediated Transfer of a Dominant-Negative H- ras Suppresses Neointimal Formation in Balloon-Injured Arteries In Vivo
H Ueno, H Yamamoto, S Ito, JJ Li, A Takeshita |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
Modulation of Growth Factor Action: Implications for the Treatment of Cardiovascular Diseases
J Waltenberger |
Circulation | 1997 |
Adenovirus-Mediated Expression of the Secreted Form of Basic Fibroblast Growth Factor (FGF-2) Induces Cellular Proliferation and Angiogenesis In Vivo
H Ueno, JJ Li, S Masuda, Z Qi, H Yamamoto, A Takeshita |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
Augmented Adenovirus-Mediated Gene Transfer to Atherosclerotic Vessels
H Ooboshi, CD Rios, Y Chu, SD Christenson, FM Faraci, BL Davidson, DD Heistad |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
Local Expression of C-Type Natriuretic Peptide Markedly Suppresses Neointimal Formation in Rat Injured Arteries Through an Autocrine/Paracrine Loop
H Ueno, A Haruno, N Morisaki, M Furuya, K Kangawa, A Takeshita, Y Saito |
Circulation | 1997 |
Downregulation of Cyclin G1 Expression by Retrovirus-Mediated Antisense Gene Transfer Inhibits Vascular Smooth Muscle Cell Proliferation and Neointima Formation
NL Zhu, L Wu, PX Liu, EM Gordon, WF Anderson, VA Starnes, FL Hall |
Circulation | 1997 |
Temporally and Spatially Coordinated Expression of Cell Cycle Regulatory Factors After Angioplasty
GL Wei, K Krasinski, M Kearney, JM Isner, K Walsh, V Andres |
Circulation research | 1997 |
Inhibition of Vascular Smooth Muscle Cell Proliferation and Neointimal Accumulation by Adenovirus-Mediated Gene Transfer of Cytosine Deaminase
RL Harrell, MA Rajanayagam, AM Doanes, RJ Guzman, EA Hirschowitz, RG Crystal, SE Epstein, T Finkel |
Circulation | 1997 |
Arterial Remodeling: A Critical Factor in Restenosis
A Lafont, EJ Topol |
1997 | |
Novel Methods in Molecular and Cellular Biochemistry of Muscle
GN Pierce, WC Claycomb |
1997 | |
p53 expression induces apoptosis in hippocampal pyramidal neuron cultures
J Jordán, M F Galindo, J H Prehn, R R Weichselbaum, M Beckett, G D Ghadge, R P Roos, J M Leiden, R J Miller |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 1997 |
Novel methods for adenovirus-mediated gene transfer to blood vessels in vivo
H Ooboshi, C D Ríos, D D Heistad |
Molecular and Cellular Biochemistry | 1997 |
p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures
Jordán J, Galindo MF, Prehn JH, Weichselbaum RR, Beckett M, Ghadge GD, Roos RP, Leiden JM, Miller RJ |
Journal of Neuroscience | 1997 |
Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
R E Law, W P Meehan, X P Xi, K Graf, D A Wuthrich, W Coats, D Faxon, W A Hsueh |
Journal of Clinical Investigation | 1996 |
Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis
JW Pippin, Q Qu, L Meijer, SJ Shankland |
Journal of Clinical Investigation | 1996 |
Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis
JW Pippin, Q Qu, L Meijer, SJ Shankland |
Kidney International | 1996 |
Molecular biology and post-angioplasty restenosis
S Nikol, TY Huehns, B Höfling |
Atherosclerosis | 1996 |
Role of the p21 cyclin-dependent kinase inhibitor in limiting intimal cell proliferation in response to arterial injury
ZY Yang, RD Simari, ND Perkins, H San, D Gordon, GJ Nabel, EG Nabel |
Proceedings of the National Academy of Sciences | 1996 |
Reactive oxygen species are downstream mediators of p53-dependent apoptosis
TM Johnson, ZX Yu, VJ Ferrans, RA Lowenstein, T Finkel |
Proceedings of the National Academy of Sciences | 1996 |
Molecular Therapies for Vascular Diseases
GH Gibbons, VJ Dzau |
Science | 1996 |
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal |
Advances in Pharmacology | 1994 |