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Citations to this article

Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects.
S Nozaki, … , J Miyagawa, K Kameda-Takemura
S Nozaki, … , J Miyagawa, K Kameda-Takemura
Published October 1, 1995
Citation Information: J Clin Invest. 1995;96(4):1859-1865. https://doi.org/10.1172/JCI118231.
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Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects.

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Abstract

To clarify the physiological roles of CD36 as an oxidized low density lipoprotein (OxLDL) receptor, we analyzed the monocyte-derived macrophages from normal and two CD36-deficient subjects, since we identified the molecular abnormalities (Kashiwagi, H., Y. Tomiyama, Y. Kosugi, M. Shiraga, R. H. Lipsky, Y. Kanayama, Y. Kurata, and Y. Matsuzawa 1994. Blood. 83:3545-3552; and Kashiwagi, H., Y. Tomiyama, S. Honda, S. Kosugi, M. Shiraga, N. Nagao, S. Sekiguchi, Y. Kanayama, Y. Kurata, and Y. Matsuzawa. 1995. J. Clin. Invest. 95:1040-1046). Scatchard analysis of 125I-OxLDL binding showed a linear plot and the maximum binding was lower by approximately 40% in the macrophages from subjects with CD36 deficiency than those from normal controls. Competition studies showed that the uptake of 125I-OxLDL was suppressed by OKM5, an antibody against CD36, by 53% in normal control macrophages, but not in the CD36-deficient macrophages. After incubation with OxLDL for 24 h, cholesteryl ester mass accumulation was reduced by approximately 40% in the macrophages from CD36-deficient subjects than those from normal controls. These results suggest that CD36 is one of the physiological receptors for OxLDL. Since specific binding of OxLDL was only reduced by approximately 40% in spite of the complete deficiency of CD36, several other receptors also may have some role in OxLDL uptake. Further studies will be needed to assess the quantitative role of CD36 in foam cell formation in vivo.

Authors

S Nozaki, H Kashiwagi, S Yamashita, T Nakagawa, B Kostner, Y Tomiyama, A Nakata, M Ishigami, J Miyagawa, K Kameda-Takemura

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D Zapolska-Downar, A Siennicka, K Chełstowski, K Widecka, I Gorący, M Hałasa, B Machaliński, M Naruszewicz
Journal of Hypertension 2006
In vivo cholesteryl ester selective uptake of mildly and standardly oxidized LDL occurs by both parenchymal and nonparenchymal mouse hepatic cells but SR-BI is only responsible for standardly oxidized LDL selective uptake by nonparenchymal cells
G Bourret, MR Brodeur, V Luangrath, J Lapointe, L Falstrault, L Brissette
The International Journal of Biochemistry & Cell Biology 2006
The association between CD36 and Lyn protein tyrosine kinase is mediated by lipid
RF Thorne, EG Law, CA Elith, KJ Ralston, RC Bates, GF Burns
Biochemical and Biophysical Research Communications 2006
PPARγ activation induces CD36 expression and stimulates foam cell like changes in rVSMCs
HJ Lim, S Lee, KS Lee, JH Park, Y Jang, EJ Lee, HY Park
Prostaglandins & Other Lipid Mediators 2006
Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages
Y Luan, HR Griffiths
Archives of Biochemistry and Biophysics 2006
Phospholipid Hydroxyalkenals, a Subset of Recently Discovered Endogenous CD36 Ligands, Spontaneously Generate Novel Furan-containing Phospholipids Lacking CD36 Binding Activity in Vivo
S Gao, R Zhang, ME Greenberg, M Sun, X Chen, BS Levison, RG Salomon, SL Hazen
The Journal of biological chemistry 2006
Antagonistic Effects of Oxidized Low Density Lipoprotein and α-Tocopherol on CD36 Scavenger Receptor Expression in Monocytes: INVOLVEMENT OF PROTEIN KINASE B AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ
A Munteanu, M Taddei, I Tamburini, E Bergamini, A Azzi, JM Zingg
The Journal of biological chemistry 2006
RUNX3 Negatively Regulates CD36 Expression in Myeloid Cell Lines
A Puig-Kröger, A Domínguez-Soto, L Martínez-Muñoz, D Serrano-Gómez, M Lopez-Bravo, E Sierra-Filardi, E Fernández-Ruiz, N Ruiz-Velasco, C Ardavín, Y Groner, N Tandon, AL Corbí, MA Vega
Journal of immunology (Baltimore, Md. : 1950) 2006
Light-induced Oxidation of Photoreceptor Outer Segment Phospholipids Generates Ligands for CD36-mediated Phagocytosis by Retinal Pigment Epithelium
M Sun, SC Finnemann, M Febbraio, L Shan, SP Annangudi, EA Podrez, G Hoppe, R Darrow, DT Organisciak, RG Salomon, RL Silverstein, SL Hazen
The Journal of biological chemistry 2005
CD36:A Multiligand Molecule
Y Ge, MT Elghetany
Laboratory Hematology 2005
Expression of Scavenger Receptor CD36 in Chronic Renal Failure Patients
M Chmielewski, E Bryl, L Marzec, E Aleksandrowicz, JM Witkowski, B Rutkowski
Artificial Organs 2005
Glycolaldehyde-Modified Bovine Serum Albumin Downregulates Leptin Expression in Mouse Adipocytes via a CD36-Mediated Pathway
Y Unno, M Sakai, YI Sakamoto, A Kuniyasu, R Nagai, H Nakayama, S Horiuchi
Annals of the New York Academy of Sciences 2005
CD36 Is Not Involved in Scavenger Receptor–Mediated Endocytic Uptake of Glycolaldehyde- and Methylglyoxal-Modified Proteins by Liver Endothelial Cells
K Nakajou, S Horiuchi, M Sakai, K Hirata, M Tanaka, M Takeya, T Kai, M Otagiri
Journal of Biochemistry 2005
Increased Risk of Colorectal Cancer Due to Interactions Between Meat Consumption and the CD36 Gene A52C Polymorphism Among Japanese
K Kuriki, N Hamajima, H Chiba, Y Kanemitsu, T Hirai, T Kato, T Saito, K Matsuo, K Koike, S Tokudome, K Tajima
Nutrition and Cancer 2005
Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages
B Fuhrman, N Volkova, M Aviram
The Journal of Nutritional Biochemistry 2005
Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis
AS Antonov, FD Kolodgie, DH Munn, RG Gerrity
The American Journal of Pathology 2004
Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36
Y Unno, M Sakai, Y Sakamoto, A Kuniyasu, H Nakayama, R Nagai, S Horiuchi
Biochemical and Biophysical Research Communications 2004
The role of scavenger receptor class B type I (SR-BI) in lipid trafficking
D Rhainds, L Brissette
The International Journal of Biochemistry & Cell Biology 2004
Normal and pathological human testes express hormone-sensitive lipase and the lipid receptors CLA-1/SR-BI and CD36
MI Arenas, MV Lobo, E Caso, L Huerta, R Paniagua, MA Martı́n-Hidalgo
Human Pathology 2004
Expression of CD36 in Macrophages and Atherosclerosis The Role of Lipid Regulation of PPARγ Signaling
AC Nicholson
Trends in Cardiovascular Medicine 2004
Atorvastatin enhances cellular uptake of oxidized LDL in adipocytes from hypercholesterolemic rabbits
SP Zhao, DQ Zhang
Clinica Chimica Acta 2004
CD36, oxidized LDL and PPARγ: pathological interactions in macrophages and atherosclerosis
AC Nicholson, DP Hajjar
Vascular Pharmacology 2004
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-γ ligands Putative contribution of Rho GTPases in statin-induced CD36 expression
N Ruiz-Velasco, A Domı́nguez, MA Vega
Biochemical Pharmacology 2004
Expression of Class A Scavenger Receptor Is Enhanced by High Glucose in Vitro and under Diabetic Conditions in Vivo: ONE MECHANISM FOR AN INCREASED RATE OF ATHEROSCLEROSIS IN DIABETES
K Fukuhara-Takaki, M Sakai, Y Sakamoto, M Takeya, S Horiuchi
The Journal of biological chemistry 2004
Role of Oxidative Modifications in Atherosclerosis
R Stocker, JF Keaney
Physiological reviews 2004
HIV Protease Inhibitors Promote Atherosclerotic Lesion Formation Independent of Dyslipidemia by Increasing CD36-Dependent Cholesteryl Ester Accumulation in Macrophages
James Dressman Jeanie Kincer Sergey V. Matveev Ling Guo Richard N. Greenberg Theresa Guerin David Meade Xiang-An Li Weifei Zhu Annette Uittenbogaard Melinda E. Wilson Eric J. Smart
Journal of Clinical Investigation 2003
The Role of Human and Mouse Hepatic Scavenger Receptor Class B Type I (SR-BI) in the Selective Uptake of Low-Density Lipoprotein−Cholesteryl Esters
D Rhainds, M Brodeur, J Lapointe, D Charpentier, L Falstrault, L Brissette
Biochemistry 2003
Phospholipids in oxidized LDL not adducted to apoB are recognized by the CD36 scavenger receptor
EA Podrez, G Hoppe, J O’Neil, HF Hoff
Free radical biology & medicine 2003
The role of CD36 in peripheral nerve remyelination after crush injury
M Eto, H Yoshikawa, H Fujimura, I Naba, H Sumi-Akamaru, S Takayasu, H Itabe, S Sakoda
European Journal of Neuroscience 2003
Oxidized Low-density Lipoproteins: What Is Understood and What Remains to Be Clarified
H Itabe
Biological & Pharmaceutical Bulletin 2003
Unsaturated fatty acids and their oxidation products stimulate CD36 expression in human macrophages
JC Vallvé, K Uliaque, J Girona, A Cabré, J Ribalta, M Heras, L Massana, M Alegret
Clínica e Investigación en Arteriosclerosis 2003
Molecular Mechanisms of Atherogenesis and Restenosis : Possible Roles of Oxidized LDL and Oxidized LDL Receptors
N Kume
Japanese Journal of Neurosurgery 2003
Endocytosis of Oxidized Low Density Lipoprotein through Scavenger Receptor CD36 Utilizes a Lipid Raft Pathway That Does Not Require Caveolin-1
Y Zeng, N Tao, KN Chung, JE Heuser, DM Lublin
The Journal of biological chemistry 2003
The Macrophage as Therapeutic Target
S Gordon
2003
Novel 5' exon of scavenger receptor CD36 is expressed in cultured human vascular smooth muscle cells and atherosclerotic plaques
JM Zingg, R Ricciarelli, E Andorno, A Azzi
Arteriosclerosis, thrombosis, and vascular biology 2002
Oxidized phosphatidylcholines: pattern recognition ligands for multiple pathways of the innate immune response
SL Hazen, GM Chisolm
Proceedings of the National Academy of Sciences 2002
Peroxisome-proliferator-activated-receptor gamma (PPARgamma) independent induction of CD36 in THP-1 monocytes by retinoic acid
S Han, N Sidell
Immunology 2002
CD36 mRNA and Protein Expression Levels Are Significantly Increased in the Heart and Testis of apoE Deficient Mice in Comparison to Wild Type (C57BL/6)
K Zibara, E Malaud, JL McGregor
Journal of Biomedicine and Biotechnology 2002
Expression of Lipoprotein Receptors in the Aortic Walls of Diabetic APA hamsters
J YAMANOUCHI, A TAKATORI, E NISHIDA, S KAWAMURA, Y YOSHIKAWA
Experimental Animals 2002
Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL
M Zhao, Y Liu, X Wang, L New, J Han, UT Brunk
APMIS 2002
Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase
B Fuhrman, N Volkova, M Aviram
Atherosclerosis 2002
CD36 deficiency induced by antiretroviral therapy
L Serghides, S Nathoo, S Walmsley, KC Kain
AIDS 2002
The Class A Scavenger Receptor Binds to Proteoglycans and Mediates Adhesion of Macrophages to the Extracellular Matrix
J Santiago-Garcı́a, T Kodama, RE Pitas
The Journal of biological chemistry 2002
Angiotensin II administration to atherosclerotic mice increases macrophage uptake of oxidized ldl: a possible role for interleukin-6
S Keidar, R Heinrich, M Kaplan, T Hayek, M Aviram
Arteriosclerosis, thrombosis, and vascular biology 2001
Japanese Journal of Thrombosis and Hemostasis
M OKUDAIRA, H ASAKURA, Y SANO, Y SUGA, M YAMAZAKI, K AOSHIMA, E MORISHITA, M SAITO, Y ONTACHI, T MIZUTANI, M KATO, T ITO, K MIYAMOTO, S NAKAO
Japanese Journal of Thrombosis and Hemostasis 2001
C-terminal fragment of α1-antitrypsin activates human monocytes to a pro-inflammatory state through interactions with the CD36 scavenger receptor and LDL receptor
S Janciauskiene, F Moraga, S Lindgren
Atherosclerosis 2001
Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36
RA Guy, GF Maguire, I Crandall, PW Connelly, KC Kain
Atherosclerosis 2001
Erythroid involvement in CD36 deficiency
K Toba, H Hanawa, K Watanabe, I Fuse, M Masuko, S Miyajima, M Takahashi, M Sakaue, T Abo, Y Aizawa
Experimental Hematology 2001
Role of CD36, the Macrophage Class B Scavenger Receptor, in Atherosclerosis
AC Nicholson, J Han, M Febbraio, RL Silversterin, DP Hajjar
Annals of the New York Academy of Sciences 2001
A patient with type I CD36 deficiency whose myocardium accumulated123I-BMIPP after 4 years
K Ito, H Sugihara, T Tanabe, K Zen, T Hikosaka, Y Adachi, S Katoh, A Azuma, M Nakagawa
Annals of Nuclear Medicine 2001
Localization of CD36 and scavenger receptor class A in human coronary arteries — a possible difference in the contribution of both receptors to plaque formation
Y Nakagawa-Toyama
Atherosclerosis 2001
Reduced Adhesion of Monocyte-Derived Macrophages from CD36-Deficient Patients to Type I Collagen
M Janabi, S Yamashita, K Hirano, K Matsumoto, N Sakai, H Hiraoka, H Kashiwagi, Y Tomiyama, S Nozaki, Y Matsuzawa
Biochemical and Biophysical Research Communications 2001
Atherosclerosis and Autoimmunity
EC Lau
Atherosclerosis and Autoimmunity 2001
Carbon Monoxide and Cardiovascular Functions
R Johnson, F Johnson
Carbon Monoxide and Cardiovascular Functions 2001
Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
N Ouchi, S Kihara, Y Arita, M Nishida, A Matsuyama, Y Okamoto, M Ishigami, H Kuriyama, K Kishida, H Nishizawa, K Hotta, M Muraguchi, Y Ohmoto, S Yamashita, T Funahashi, Y Matsuzawa
Circulation 2001
A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation
E Griffin, A Re, N Hamel, C Fu, H Bush, T McCaffrey, AS Asch
Nature Medicine 2001
Localization of the Lipid Receptors CD36 and CLA-1/SR-BI in the Human Gastrointestinal Tract: Towards the Identification of Receptors Mediating the Intestinal Absorption of Dietary Lipids
MV Lobo, L Huerta, N RuizVelasco, E Teixeiro, P la Cueva, A Celdrán, A MartínHidalgo, MA Vega, R Bragado
Journal of Histochemistry & Cytochemistry 2001
Binding and uptake of differently oxidized low density lipoprotein in mouse peritoneal macrophages and THP-1 macrophages: Involvement of negative charges as well as oxidation-specific epitopes
X Wang, J Greilberger, G Ledinski, G Kager, G Jrgens
Journal of Cellular Biochemistry 2001
Secreted Forms of the Amyloid-β Precursor Protein Are Ligands for the Class A Scavenger Receptor
J Santiago-Garcı́a, J Mas-Oliva, TL Innerarity, RE Pitas
The Journal of biological chemistry 2001
Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL
Z Chen, S Ishibashi, S Perrey, J Osuga, T Gotoda, T Kitamine, Y Tamura, H Okazaki, N Yahagi, Y Iizuka, F Shionoiri, K Ohashi, K Harada, H Shimano, R Nagai, N Yamada
Arteriosclerosis, thrombosis, and vascular biology 2001
12/15-Lipoxygenase Gene Disruption Attenuates Atherogenesis in LDL Receptor–Deficient Mice
J George, A Afek, A Shaish, H Levkovitz, N Bloom, T Cyrus, L Zhao, CD Funk, E Sigal, D Harats
Circulation 2001
Induction of CD36 by all‐trans retinoic acid: retinoic acid receptor signaling in the pathogenesis of atherosclerosis
DM Wuttge, A Romert, U Eriksson, H Törmä, GK Hansson, A Sirsjö
The FASEB Journal 2001
α-Tocopherol decreases CD36 expression in human monocyte-derived macrophages
S Devaraj, I Hugou, I Jialal
Journal of lipid research 2001
CD36 does not play a direct role in HDL or LDL metabolism
WJ de Villiers, L Cai, NR Webb, MC de Beer, DR van der Westhuyzen, FC de Beer
Journal of lipid research 2001
Targeted disruption of the class B scavenger receptor, CD36, protects against atherosclerotic lesion development in mice
Maria Febbraio, Eugene A. Podrez, Jonathan Smith, David P. Hajjar, Stanley L. Hazen, Henry F. Hoff, Kavita Sharma, Roy L. Silverstein
Journal of Clinical Investigation 2000
Oxidized low density lipoprotein reduces monocyte CCR2 expression through pathways that involve activation of peroxisome proliferator-activated receptor gamma (PPARgamma)
Ki Hoon Han, Mi Kyung Chang, Agnes Boullier, Simone R. Green, Andrew Li, Christopher K. Glass, Oswald Quehenberger
Journal of Clinical Investigation 2000
Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
EA Podrez, M Febbraio, N Sheibani, D Schmitt, RL Silverstein, DP Hajjar, PA Cohen, WA Frazier, HF Hoff, SL Hazen
Journal of Clinical Investigation 2000
Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol
H Yanai, H Chiba, M Morimoto, K Abe, H Fujiwara, H Fuda, SP Hui, Y Takahashi, H Akita, GA Jamieson, K Kobayashi, K Matsuno
American Journal of Medical Genetics 2000
Regulation of fatty acid transporters in mammalian cells
BI Frohnert, DA Bernlohr
Progress in Lipid Research 2000
Scavenger receptor regulation and atherosclerosis
JM Zingg, R Ricciarelli, A Azzi
BioFactors 2000
Losartan Inhibits Cellular Uptake of Oxidized LDL by Monocyte-Macrophages from Hypercholesterolemic Patients
T Hayek, M Aviram, R Heinrich, E Sakhnini, S Keidar
Biochemical and Biophysical Research Communications 2000
CD36 and atherosclerosis
RL Silverstein, M Febbraio
Current Opinion in Lipidology 2000
Advanced Glycation End Products-Induced Gene Expression of Scavenger Receptors in Cultured Human Monocyte-Derived Macrophages
Y Iwashima, M Eto, A Hata, K Kaku, S Horiuchi, F Ushikubi, H Sano
Biochemical and Biophysical Research Communications 2000
Apoptosis induced by oxidized low density lipoprotein in human monocyte-derived macrophages involves CD36 and activation of caspase-3
ES Wintergerst, J Jelk, C Rahner, R Asmis
European Journal of Biochemistry 2000
Fatty Acid Transport Regulatory Proteins in the Developing Rat Placenta and in Trophoblast Cell Culture Models
GT Knipp, B Liu, KL Audus, H Fujii, T Ono, MJ Soares
Placenta 2000
PS-Liposome and Ox-LDL Bind to Different Sites of the Immunodominant Domain (#155-183) of CD36
A Yamaguchi, N Yamamoto, N Akamatsu, TC Saido, M Kaneda, M Umeda, K Tanoue
Thrombosis Research 2000
The Adhesion Molecule FactsBook
CM Isacke, MA Horton
The Adhesion Molecule FactsBook 2000
The Binding of Oxidized Low Density Lipoprotein to Mouse CD36 Is Mediated in Part by Oxidized Phospholipids That Are Associated with Both the Lipid and Protein Moieties of the Lipoprotein
A Boullier, KL Gillotte, S Hörkkö, SR Green, P Friedman, EA Dennis, JL Witztum, D Steinberg, O Quehenberger
The Journal of biological chemistry 2000
CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products
N Ohgami, R Nagai, M Ikemoto, H Arai, A Kuniyasu, S Horiuchi, H Nakayama
The Journal of biological chemistry 2000
TGF-β1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages
G Draude, RL Lorenz
American journal of physiology. Heart and circulatory physiology 2000
Vitamin E Reduces the Uptake of Oxidized LDL by Inhibiting CD36 Scavenger Receptor Expression in Cultured Aortic Smooth Muscle Cells
R Ricciarelli, JM Zingg, A Azzi
Circulation 2000
Hepatic and Extrahepatic Scavenger Receptors: Function in Relation to Disease
V Terpstra, ES van Amersfoort, AG van Velzen, J Kuiper, TJ van Berkel
Arteriosclerosis, thrombosis, and vascular biology 2000
Expression of Macrophage (Mφ) Scavenger Receptor, CD36, in Cultured Human Aortic Smooth Muscle Cells in Association With Expression of Peroxisome Proliferator Activated Receptor-γ, Which Regulates Gain of Mφ-Like Phenotype In Vitro, and Its Implication in Atherogenesis
K Matsumoto, K Hirano, S Nozaki, A Takamoto, M Nishida, Y Nakagawa-Toyama, MY Janabi, T Ohya, S Yamashita, Y Matsuzawa
Arteriosclerosis, thrombosis, and vascular biology 2000
Oxidative Stress and Vascular Disease
JF Keaney
2000
Lipoprotein Metabolism and Atherogenesis
T Kita, M Yokode
2000
Macrophage receptors responsible for distinct recognition of low density lipoprotein containing pyrrole or pyridinium adducts: models of oxidized low density lipoprotein
EA Podrez, G Hoppe, J O'Neil, LM Sayre, N Sheibani, HF Hoff
Journal of lipid research 2000
Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-γ
J Feng, J Han, SF Pearce, RL Silverstein, AM Gotto, DP Hajjar, AC Nicholson
Journal of lipid research 2000
Apoptotic Thymocyte Clearance in Scavenger Receptor Class A-Deficient Mice Is Apparently Normal
N Platt, H Suzuki, T Kodama, S Gordon
Journal of immunology (Baltimore, Md. : 1950) 2000
The Role of Scavenger Receptor Class A in the Adhesion of Cells Is Dependent on Cell Type and Cellular Activation State
W Ling, M Lougheed, H Suzuki, A Buchan, T Kodama, UP Steinbrecher
Journal of Clinical Investigation 1999
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
T Cyrus, JL Witztum, DJ Rader, R Tangirala, S Fazio, MF Linton, CD Funk
Journal of Clinical Investigation 1999
Uptake and fate of class B scavenger receptor ligands in HepG2 cells
D Rhainds, L Falstrault, C Tremblay, L Brissette
European Journal of Biochemistry 1999
Scavenger receptors and oxidized low density lipoproteins
BS Dhaliwal, UP Steinbrecher
Clinica Chimica Acta 1999
Nutrient transport across the placenta
GT Knipp, KL Audus, MJ Soares
Advanced Drug Delivery Reviews 1999
Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells
DA Bird, KL Gillotte, S Hörkkö, P Friedman, EA Dennis, JL Witztum, D Steinberg
Proceedings of the National Academy of Sciences 1999
Low density lipoprotein uptake: holoparticle and cholesteryl ester selective uptake
D Rhainds, L Brissette
The International Journal of Biochemistry & Cell Biology 1999
Activation of monocytes in vivo causes intracellular accumulation of lipoprotein-derived lipids and marked hypocholesterolemia—a possible pathogenesis of necrobiotic xanthogranuloma
F Matsuura, S Yamashita, K Hirano, M Ishigami, H Hiraoka, R Tamura, T Nakagawa, M Nishida, N Sakai, T Nakamura, S Nozaki, T Funahashi, C Matsumoto, M Higashiyama, K Yoshikawa, Y Matsuzawa
Atherosclerosis 1999
Regulation of macrophage gene expression by peroxisome-proliferator-activated receptor y
P Tontonoz, L Nagy
Current Opinion in Lipidology 1999
Time-Resolved Fluorometric Assay for Measuring Cell Binding and Association of Native and Oxidized Low-Density Lipoproteins to Macrophages
X Wang, J Greilberger, G Jürgens
Analytical Biochemistry 1999
Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells
DA Bird, KL Gillotte, S Horkko, P Friedman, EA Dennis, JL Witztum, D Steinberg
Proceedings of the National Academy of Sciences 1999
The Role of Scavenger Receptor Class A in the Adhesion of Cells Is Dependent on Cell Type and Cellular Activation State
W Ling, M Lougheed, H Suzuki, A Buchan, T Kodama, UP Steinbrecher
Experimental Cell Research 1999
Human platelets exclusively bind oxidized low density lipoprotein showing no specificity for acetylated low density lipoprotein
I Volf, T Moeslinger, J Cooper, W Schmid, E Koller
FEBS Letters 1999
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions
H Kataoka, N Kume, S Miyamoto, M Minami, H Moriwaki, T Murase, T Sawamura, T Masaki, N Hashimoto, T Kita
Circulation 1999
A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
M Febbraio, NA Abumrad, DP Hajjar, K Sharma, W Cheng, SF Pearce, RL Silverstein
The Journal of biological chemistry 1999
The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin
G Draude, N Hrboticky, RL Lorenz
Biochemical Pharmacology 1999
Specific interaction of oxidized low-density lipoprotein with macrophage-derived foam cells isolated from rabbit atherosclerotic lesions
H E de Vries, B Buchner, T J van Berkel, J Kuiper
Arteriosclerosis, thrombosis, and vascular biology 1999
Receptors for oxidized low density lipoprotein
UP Steinbrecher
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1999
Distinct scavenger receptor expression and function in the human CD14 + /CD16 + monocyte subset
G Draude, P Hundelshausen, M Frankenberger, HW Ziegler-Heitbrock, C Weber
American journal of physiology. Heart and circulatory physiology 1999
CD36, a Novel Receptor for Oxidized Low-Density Lipoproteins, Is Highly Expressed on Lipid-Laden Macrophages in Human Atherosclerotic Aorta
A Nakata, Y Nakagawa, M Nishida, S Nozaki, J Miyagawa, T Nakagawa, R Tamura, K Matsumoto, K Kameda-Takemura, S Yamashita, Y Matsuzawa
Arteriosclerosis, thrombosis, and vascular biology 1999
Expression of Human Scavenger Receptor Class B Type I in Cultured Human Monocyte-Derived Macrophages and Atherosclerotic Lesions
K Hirano, S Yamashita, Y Nakagawa, T Ohya, F Matsuura, K Tsukamoto, Y Okamoto, A Matsuyama, K Matsumoto, J Miyagawa, Y Matsuzawa
Circulation research 1999
Uptake of Oxidized LDL by Macrophages Differs From That of Acetyl LDL and Leads to Expansion of an Acidic Endolysosomal Compartment
M Lougheed, ED Moore, DR Scriven, UP Steinbrecher
Arteriosclerosis, thrombosis, and vascular biology 1999
Lovastatin Decreases the Receptor-Mediated Degradation of Acetylated and Oxidized LDLs in Human Blood Monocytes During the Early Stage of Differentiation Into Macrophages
N Hrboticky, G Draude, G Hapfelmeier, R Lorenz, PC Weber
Arteriosclerosis, thrombosis, and vascular biology 1999
Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila
NC Franc, P Heitzler, RA B., Ezekowitz, K White
Science 1999
Mechanisms of cellular uptake of long chain free fatty acids
P D Berk, D D Stump
Molecular and Cellular Biochemistry 1999
CD36 antisense expression in 3T3-F442A preadipocytes
Z Sfeir, A Ibrahimi, E Amri, P Grimaldi, N Abumrad
Molecular and Cellular Biochemistry 1999
Oxidized phospholipids as a new landmark in atherosclerosis
H Itabe
Progress in Lipid Research 1998
Expression of lipoprotein receptors in atherosclerotic lesions
TP Hiltunen, S Ylä-Herttuala
Atherosclerosis 1998
Myocardial CD36 expression and fatty acid accumulation in patients with type I and II CD36 deficiency
K Watanabe, Y Ohta, K Toba, Y Ogawa, H Hanawa, Y Hirokawa, M Kodama, N Tanabe, S Hirono, Y Ohkura, Y Nakamura, K Kato, Y Aizawa, I Fuse, S Miyajima, Y Kusano, T Nagamoto, G Hasegawa, M Naito
Annals of Nuclear Medicine 1998
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
L Nagy, P Tontonoz, JG Alvarez, H Chen, RM Evans
Cell 1998
Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor
H Yoshida, N Kondratenko, S Green, D Steinberg, O Quehenberger
Biochemical Journal 1998
Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors
V Terpstra, DA Bird, D Steinberg
Proceedings of the National Academy of Sciences 1998
Complementary roles for scavenger receptor A and CD36 of human monocyte-derived macrophages in adhesion to surfaces coated with oxidized low-density lipoproteins and in secretion of H2O2
H Maxeiner, J Husemann, CA Thomas, JD Loike, JE Khoury, SC Silverstein
Journal of Experimental Medicine 1998
Complementary Roles for Scavenger Receptor A and CD36 of Human Monocyte-derived Macrophages in Adhesion to Surfaces Coated with Oxidized Low-Density Lipoproteins and in Secretion of H2O2
H Maxeiner, J Husemann, CA Thomas, JD Loike, JE Khoury, SC Silverstein
Journal of Experimental Medicine 1998
Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-α
H Moriwaki, N Kume, H Kataoka, T Murase, E Nishi, T Sawamura, T Masaki, T Kita
FEBS Letters 1998
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
P Tontonoz, L Nagy, JG Alvarez, VA Thomazy, RM Evans
Cell 1998
Bases celulares y moleculares de la acumulación de colesterol en la pared vascular y su contribución a la progresión de la lesión aterosclerótica
V Llorente, L Badimon
Revista Española de Cardiología 1998
Oxidized LDL Increases and Interferon-γ Decreases Expression of CD36 in Human Monocyte–Derived Macrophages
T Nakagawa, S Nozaki, M Nishida, JM Yakub, Y Tomiyama, A Nakata, K Matsumoto, T Funahashi, K Kameda-Takemura, Y Kurata, S Yamashita, Y Matsuzawa
Arteriosclerosis, thrombosis, and vascular biology 1998
Minimally Oxidized Low-Density Lipoprotein Increases Expression of Scavenger Receptor A, CD36, and Macrosialin in Resident Mouse Peritoneal Macrophages
H Yoshida, O Quehenberger, N Kondratenko, S Green, D Steinberg
Arteriosclerosis, thrombosis, and vascular biology 1998
Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein
H Hakamata, A Miyazaki, M Sakai, H Matsuda, H Suzuki, T Kodama, S Horiuchi
Journal of lipid research 1998
Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
D Calvo, D Gómez-Coronado, Y Suárez, MA Lasunción, MA Vega
Journal of lipid research 1998
CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells
DW Dawson, SF Pearce, R Zhong, RL Silverstein, WA Frazier, NP Bouck
The Journal of Cell Biology 1997
Dietary antioxidants and cardioprotection—fact or fallacy?
UP Steinbrecher
Canadian Journal of Physiology and Pharmacology 1997
The Leucocyte Antigen FactsBook
AN Barclay, MH Brown, SK Law, AJ McKnight, MG Tomlinson, PA van der Merwe
The Leucocyte Antigen FactsBook 1997
High Affinity Saturable Uptake of Oxidized Low Density Lipoprotein by Macrophages from Mice Lacking the Scavenger Receptor Class A Type I/II
M Lougheed, CM Lum, W Ling, H Suzuki, T Kodama, U Steinbrecher
The Journal of biological chemistry 1997
Native and Modified Low Density Lipoproteins Increase the Functional Expression of the Macrophage Class B Scavenger Receptor, CD36
J Han, DP Hajjar, M Febbraio, AC Nicholson
The Journal of biological chemistry 1997
Independent Mechanisms for Macrophage Binding and Macrophage Phagocytosis of Damaged Erythrocytes: Evidence of Receptor Cooperativity
GR Sambrano, V Terpstra, D Steinberg
Arteriosclerosis, thrombosis, and vascular biology 1997
Lewis A. Conner Memorial Lecture: Oxidative Modification of LDL and Atherogenesis
D Steinberg
Circulation 1997
Human Monocyte–Derived Macrophages Express an ≈120-kD Ox-LDL Binding Protein With Strong Identity to CD68
MA van der Kooij, EM von der Mark, JK Kruijt, A van Velzen, TJ van Berkel, OH Morand
Arteriosclerosis, thrombosis, and vascular biology 1997
CLA-1 Is an 85-kD Plasma Membrane Glycoprotein That Acts as a High-Affinity Receptor for Both Native (HDL, LDL, and VLDL) and Modified (OxLDL and AcLDL) Lipoproteins
D Calvo, D Gómez-Coronado, MA Lasunción, MA Vega
Arteriosclerosis, thrombosis, and vascular biology 1997
Functional roles of membrane glycoprotein CD36
L Daviet, JL McGregor
Platelets 1996
Scavenger receptors in innate immunity
AM Pearson
Current Opinion in Immunology 1996
Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein
MP Ramprasad, V Terpstra, N Kondratenko, O Quehenberger, D Steinberg
Proceedings of the National Academy of Sciences 1996
To tell the truth: Will the real CD36 please stand up?
A Asch
Journal of Laboratory and Clinical Medicine 1996
Mechanism of Uptake of Copper-oxidized Low Density Lipoprotein in Macrophages Is Dependent on Its Extent of Oxidation
M Lougheed, UP Steinbrecher
The Journal of biological chemistry 1996
Regulation of Monocyte CD36 and Thrombospondin-1 Expression by Soluble Mediators
LM Yesner, HY Huh, SF Pearce, RL Silverstein
Arteriosclerosis, thrombosis, and vascular biology 1996
A Single Nucleotide Insertion in Codon 317 of the CD36 Gene Leads to CD36 Deficiency
H Kashiwagi, Y Tomiyama, S Nozaki, S Honda, S Kosugi, M Shiraga, T Nakagawa, N Nagao, Y Kanakura, Y Kurata, Y Matsuzawa
Arteriosclerosis, thrombosis, and vascular biology 1996
Drugs Affecting Lipid Metabolism
AM Gotto, R Paoletti, LC Smith, AL Catapano, AS Jackson
1996
Characterization of inherited scavenger receptor overexpression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthomas
C Giry, LM Giroux, M Roy, J Davignon, A Minnich
Journal of lipid research 1996
Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors
N Platt, S Gordon
The Journal of biological chemistry 1993

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