To clarify the physiological roles of CD36 as an oxidized low density lipoprotein (OxLDL) receptor, we analyzed the monocyte-derived macrophages from normal and two CD36-deficient subjects, since we identified the molecular abnormalities (Kashiwagi, H., Y. Tomiyama, Y. Kosugi, M. Shiraga, R. H. Lipsky, Y. Kanayama, Y. Kurata, and Y. Matsuzawa 1994. Blood. 83:3545-3552; and Kashiwagi, H., Y. Tomiyama, S. Honda, S. Kosugi, M. Shiraga, N. Nagao, S. Sekiguchi, Y. Kanayama, Y. Kurata, and Y. Matsuzawa. 1995. J. Clin. Invest. 95:1040-1046). Scatchard analysis of 125I-OxLDL binding showed a linear plot and the maximum binding was lower by approximately 40% in the macrophages from subjects with CD36 deficiency than those from normal controls. Competition studies showed that the uptake of 125I-OxLDL was suppressed by OKM5, an antibody against CD36, by 53% in normal control macrophages, but not in the CD36-deficient macrophages. After incubation with OxLDL for 24 h, cholesteryl ester mass accumulation was reduced by approximately 40% in the macrophages from CD36-deficient subjects than those from normal controls. These results suggest that CD36 is one of the physiological receptors for OxLDL. Since specific binding of OxLDL was only reduced by approximately 40% in spite of the complete deficiency of CD36, several other receptors also may have some role in OxLDL uptake. Further studies will be needed to assess the quantitative role of CD36 in foam cell formation in vivo.
S Nozaki, H Kashiwagi, S Yamashita, T Nakagawa, B Kostner, Y Tomiyama, A Nakata, M Ishigami, J Miyagawa, K Kameda-Takemura
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Impacts of CD36 Variants on Plasma Lipid Levels and the Risk of Early-Onset Coronary Artery Disease: A Systematic Review and Meta-Analysis
Luo Z, Lv L |
Cardiovascular Therapeutics | 2025 |
Neuraminidase-1 (NEU1): Biological Roles and Therapeutic Relevance in Human Disease
Du J, Shui H, Chen R, Dong Y, Xiao C, Hu Y, Wong NK |
Current Issues in Molecular Biology | 2024 |
SPA Promotes Atherosclerosis Through Mediating Macrophage Foam Cell Formation-Brief Report.
King SD, Cai D, Pillay A, Fraunfelder MM, Allen LH, Chen SY |
Arteriosclerosis, thrombosis, and vascular biology | 2024 |
Exploring the expression and potential function of follicle stimulating hormone receptor in extragonadal cells related to abdominal aortic aneurysm.
Tedjawirja VN, Mieremet A, Rombouts KB, Yap C, Neele AE, Northoff BH, Chen HJ, Vos M, Klaver D, Yeung KK, Balm R, de Waard V |
PloS one | 2023 |
Protein Phosphatase 2A Deficiency in Macrophages Increases Foam Cell Formation and Accelerates Atherosclerotic Lesion Development
R Li, C Zhang, F Xie, X Zhou, X Hu, J Shi, X Du, Z Lin, N Dong |
Frontiers in Cardiovascular Medicine | 2022 |
Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression
Cui K, Gao X, Wang B, Wu H, Arulsamy K, Dong Y, Xiao Y, Jiang X, Malovichko MV, Li K, Peng Q, Lu YW, Zhu B, Zheng R, Wong S, Cowan DB, Linton M, Srivastava S, Shi J, Chen K, Chen H |
Circulation research | 2022 |
Oxidized LDLs as Signaling Molecules
JM Zingg, A Vlad, R Ricciarelli |
Antioxidants | 2021 |
Fatty acids and evolving roles of their proteins in neurological, cardiovascular disorders and cancers
R Mallick, S Basak, AK Duttaroy |
Progress in Lipid Research | 2021 |
Citrus reticulata peel oil as an antiatherogenic agent: Hypolipogenic effect in hepatic cells, lipid storage decrease in foam cells, and prevention of LDL oxidation
MA Castro, MA Llanos, BE Rodenak-Kladniew, L Gavernet, ME Galle, R Crespo |
Nutrition, Metabolism, and Cardiovascular Diseases | 2020 |
Deubiquitination of CD36 by UCHL1 promotes foam cell formation
X Xia, Q Xu, M Liu, X Chen, X Liu, J He, T Hu, C Yu, H Huang, S Liu, N Liu |
Cell Death and Disease | 2020 |
Macrophage neuronal nitric oxide synthase (NOS1) controls the inflammatory response and foam cell formation in atherosclerosis
A Roy, U Saqib, K Wary, MS Baig |
International Immunopharmacology | 2020 |
Zafirlukast prevented ox-LDL-induced formation of foam cells
Q Song, Z Hu, X Xie, H Cai |
Toxicology and Applied Pharmacology | 2020 |
CD36 in Atherosclerosis: Pathophysiological Mechanisms and Therapeutic Implications
K Tian, Y Xu, A Sahebkar, S Xu |
Current Atherosclerosis Reports | 2020 |
Myeloperoxidase instigates proinflammatory responses in a cecal ligation and puncture rat model of sepsis
H Yu, Y Liu, M Wang, RJ Restrepo, D Wang, TJ Kalogeris, WL Neumann, DA Ford, RJ Korthuis |
American journal of physiology. Heart and circulatory physiology | 2020 |
Macrophage polarisation associated with atherosclerosis differentially affects their capacity to handle lipid
K Baidžajevas, É Hadadi, B Lee, J Lum, F Shihui, I Sudbery, E Kiss-Tóth, SC Wong, HL Wilson |
Atherosclerosis | 2020 |
Oxidative Stress in Ischemic Heart Disease
A Kibel, AM Lukinac, V Dambic, I Juric, K Selthofer-Relatic, A Daiber |
Oxidative Medicine & Cellular Longevity | 2020 |
Gender-specific associations of CD36 polymorphisms with the lipid profile and susceptibility to premature multi-vessel coronary artery heart disease in the Northern Han Chinese
Y Du, K Chen, E Liu, X Wang, F Li, T Liu, X Zheng, G Li, J Che |
Gene | 2020 |
The Significance of Oxidized Low-Density Lipoprotein in Body Fluids as a Marker Related to Diseased Conditions
H Itabe, R Kato, N Sawada, T Obama, M Yamamoto |
Current medicinal chemistry | 2019 |
Functionalization of CD36 cardiovascular disease and expression associated variants by interdisciplinary high throughput analysis
N Madan, AR Ghazi, X Kong, ES Chen, CA Shaw, LC Edelstein, FW Asselbergs |
PLoS genetics | 2019 |
Lipoprotein receptor signalling in atherosclerosis
C Mineo |
Cardiovascular Research | 2019 |
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis
AJ Kattoor, A Goel, JL Mehta |
Antioxidants | 2019 |
Bioflavonoid hesperidin possesses the anti-hyperglycemic and hypolipidemic property in STZ induced diabetic myocardial infarction (DMI) in male Wister rats
SS Rekha, JA Pradeepkiran, M Bhaskar |
Journal of Nutrition & Intermediary Metabolism | 2019 |
Cell signaling and biological pathway in cardiovascular diseases
CW Chae, YW Kwon |
Archives of Pharmacal Research | 2019 |
CD36 and lipid metabolism in the evolution of atherosclerosis
L Zhao, Z Varghese, JF Moorhead, Y Chen, XZ Ruan |
British Medical Bulletin | 2018 |
The CD36-PPARγ Pathway in Metabolic Disorders
L Maréchal, M Laviolette, A Rodrigue-Way, B Sow, M Brochu, V Caron, A Tremblay |
International journal of molecular sciences | 2018 |
Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats
Q Dong, MS Kuefner, X Deng, D Bridges, EA Park, MB Elam, R Raghow |
Biology of sex differences | 2018 |
Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex
C Kawecki, O Bocquet, CE Schmelzer, A Heinz, C Ihling, A Wahart, B Romier, A Bennasroune, S Blaise, C Terryn, KJ Linton, L Martiny, L Duca, P Maurice |
Cellular and Molecular Life Sciences | 2018 |
The role of adiponectin and adipolin as anti-inflammatory adipokines in the formation of macrophage foam cells and their association with cardiovascular diseases
J Sargolzaei, E Chamani, T Kazemi, S Fallah, H Soori |
Clinical Biochemistry | 2018 |
Metformin ameliorates Ox-LDL-induced foam cell formation in raw264.7 cells by promoting ABCG-1 mediated cholesterol efflux
X He, X Chen, L Wang, W Wang, Q Liang, L Yi, Y Wang, Q Gao |
Life Sciences | 2018 |
Vitamin E: Regulatory Role on Signal Transduction: VITAMIN E-REGULATORY ROLES
JM Zingg |
IUBMB Life | 2018 |
CD36 is upregulated in mice with periodontitis and metabolic syndrome and involved in macrophage gene upregulation by palmitate
Z Lu, Y Li, CW Brinson, KL Kirkwood, MF Lopes-Virella, Y Huang |
Oral Diseases | 2017 |
Treatment with medium chain fatty acids milk of CD36 deficient preschool children
H Nagasaka, K Hirano, T Yorifuji, H Komatsu, T Takatani, I Morioka, S Hirayama, T Miida |
Nutrition (Burbank, Los Angeles County, Calif.) | 2017 |
Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation
HS Wong, V Jaumouillé, SA Freeman, SA Doodnauth, D Schlam, J Canton, IM Mukovozov, A Saric, S Grinstein, LA Robinson |
Cell Reports | 2016 |
OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL
JC Howard, A Florentinus-Mefailoski, P Bowden, W Trimble, S Grinstein, JG Marshall |
Analytical Biochemistry | 2016 |
Virtual exploration of early stage atherosclerosis
AL Olivares, MA Ballester, J Noailly |
Bioinformatics | 2016 |
Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake
X Yang, H Yao, Y Chen, L Sun, Y Li, X Ma, S Duan, X Li, R Xiang, J Han, Y Duan |
The Journal of biological chemistry | 2015 |
LRP5 deficiency down-regulates Wnt signalling and promotes aortic lipid infiltration in hypercholesterolaemic mice
M Borrell-Pagès, JC Romero, L Badimon |
Journal of Cellular and Molecular Medicine | 2015 |
CD36 Binds Oxidized Low Density Lipoprotein (LDL) in a Mechanism Dependent upon Fatty Acid Binding
AG Jay, AN Chen, MA Paz, JP Hung, JA Hamilton |
The Journal of biological chemistry | 2015 |
Diverse CD36 expression among Japanese population: defective CD36 mutations cause platelet and monocyte CD36 reductions in not only deficient but also normal phenotype subjects
Y Masuda, S Tamura, K Matsuno, A Nagasawa, K Hayasaka, C Shimizu, T Moriyama |
Thrombosis Research | 2015 |
Accelerated transformation of macrophage-derived foam cells in the presence of collagen-induced arthritis mice serum is associated with dyslipidemia
W Wen, M He, X Liang, S Gao, J Zhou, Z Yuan |
Autoimmunity | 2015 |
Inhibition of Angiogenesis by the First Type I Repeat Peptides of Thrombospondin-1
BI Yoo, GB Jeong |
Korean Journal of Physical Anthropology | 2015 |
Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease
JJ Liu, P Green, JJ Mann, SI Rapoport, ME Sublette |
Brain Research | 2014 |
Low levels of CD36 in peripheral blood monocytes in subclinical atherosclerosis in rheumatoid arthritis: a cross-sectional study in a Mexican population
E Gómez-Bañuelos, BT Martín-Márquez, EA Martínez-García, M Figueroa-Sanchez, L Nuñez-Atahualpa, AD Rocha-Muñoz, PE Sánchez-Hernández, RE Navarro-Hernandez, PM Madrigal-Ruiz, AA Saldaña-Millan, S Duran-Barragan, L Gonzalez-Lopez, JI Gamez-Nava, MV Mercado |
BioMed Research International | 2014 |
Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling
A Płóciennikowska, A Hromada-Judycka, K Borzęcka, K Kwiatkowska |
Cellular and Molecular Life Sciences | 2014 |
Imbalanced response of ATP-binding cassette transporter A1 and CD36 expression to increased oxidized low-density lipoprotein loading contributes to the development of THP-1 derived foam cells
HY Liu, HB Cui, XM Chen, XY Chen, SH Wang, WP Du, HL Zhou, RC Zhao, Y Zhou, YH Liu, CC Cui, C Huang |
Journal of Biochemistry | 2014 |
Activated Human Mast Cells Induce LOX-1-Specific Scavenger Receptor Expression in Human Monocyte-Derived Macrophages
M Alanne-Kinnunen, J Lappalainen, K Öörni, PT Kovanen, A Zirlik |
PloS one | 2014 |
CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells
S Berre, R Gaudin, BC de Alencar, M Desdouits, M Chabaud, N Naffakh, M Rabaza-Gairi, FX Gobert, M Jouve, P Benaroch |
Journal of Experimental Medicine | 2013 |
The effect of high intensity interval exercise on postprandial triacylglycerol and leukocyte activation--monitored for 48 h post exercise
BM Gabriel, J Pugh, V Pruneta-Deloche, P Moulin, A Ratkevicius, SR Gray |
PloS one | 2013 |
Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts
FJ Rios, M Ferracini, M Pecenin, MM Koga, Y Wang, DF Ketelhuth, S Jancar |
PloS one | 2013 |
Curcumin inhibits oxLDL-induced CD36 expression and foam cell formation through the inhibition of p38 MAPK phosphorylation
K Min, HJ Um, KH Cho, TK Kwon |
Food and Chemical Toxicology | 2013 |
Uptake of oxLDL and IL-10 Production by Macrophages Requires PAFR and CD36 Recruitment into the Same Lipid Rafts
FJ Rios, M Ferracini, M Pecenin, MM Koga, Y Wang, DF Ketelhuth, S Jancar, A Cignarella |
PloS one | 2013 |
The Effect of High Intensity Interval Exercise on Postprandial Triacylglycerol and Leukocyte Activation – Monitored for 48h Post Exercise
BM Gabriel, J Pugh, V Pruneta-Deloche, P Moulin, A Ratkevicius, SR Gray, CP Earnest |
PloS one | 2013 |
Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake
N Amézaga, L Sanjurjo, J Julve, G Aran, B Pérez-Cabezas, P Bastos-Amador, C Armengol, R Vilella, JC Escolà-Gil, F Blanco-Vaca, FE Borràs, AF Valledor, MR Sarrias |
Journal of leukocyte biology | 2013 |
The innate immune response to products of phospholipid peroxidation☆
D Weismann, CJ Binder |
Biochimica et Biophysica Acta | 2012 |
Current Concepts of the Role of Oxidized LDL Receptors in Atherosclerosis
T Goyal, S Mitra, M Khaidakov, X Wang, S Singla, Z Ding, S Liu, JL Mehta |
Current Atherosclerosis Reports | 2012 |
Co-Stimulation of PAFR and CD36 Is Required for oxLDL-Induced Human Macrophages Activation
FJ Rios, MM Koga, M Ferracini, S Jancar |
PloS one | 2012 |
Macrophages, lipid metabolism and gene expression in atherogenesis: a therapeutic target of the future?
DR Michael, TG Ashlin, ML Buckley, DP Ramji |
Clinical Lipidology | 2012 |
CD36 and taste of fat :
P Degrace-Passilly, P Besnard |
Current Opinion in Clinical Nutrition & Metabolic Care | 2012 |
Patients with CD36 Deficiency Are Associated with Enhanced Atherosclerotic Cardiovascular Diseases
M Yuasa-Kawase, D Masuda, T Yamashita, R Kawase, H Nakaoka, M Inagaki, K Nakatani, K Tsubakio-Yamamoto, T Ohama, A Matsuyama, M Nishida, M Ishigami, T Kawamoto, I Komuro, S Yamashita |
Journal of Atherosclerosis and Thrombosis | 2012 |
Nuclear receptor mediated mechanisms of macrophage cholesterol metabolism
ZS Nagy, Z Czimmerer, L Nagy |
Molecular and Cellular Endocrinology | 2012 |
Functional consequences of CD36 downregulation by TLR signals
C Zamora, E Cantó, JC Nieto, MA Ortiz, C Juarez, S Vidal |
Cytokine | 2012 |
Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release
JP Truman, MM Gadban, KJ Smith, RW Jenkins, N Mayroo, G Virella, MF Lopes-Virella, A Bielawska, YA Hannun, SM Hammad |
Immunology | 2012 |
Co-Stimulation of PAFR and CD36 Is Required for oxLDL-Induced Human Macrophages Activation
FJ Rios, MM Koga, M Ferracini, S Jancar, M Pesce |
PloS one | 2012 |
Vav Family Rho Guanine Nucleotide Exchange Factors Regulate CD36-mediated Macrophage Foam Cell Formation*
SO Rahaman, W Swat, M Febbraio, RL Silverstein |
The Journal of biological chemistry | 2011 |
Electrospray MS/MS reveals extensive and nonspecific oxidation of cholesterol esters in human peripheral vascular lesions
PM Hutchins, EE Moore, RC Murphy |
Journal of lipid research | 2011 |
Oxidative Stress and Disease
I Paur, M Carlsen, B Halvorsen, R Blomhoff |
Herbal Medicine | 2011 |
CD36 deficiency predisposing young children to fasting hypoglycemia
H Nagasaka, T Yorifuji, T Takatani, Y Okano, H Tsukahara, H Yanai, K Hirano, SP Hui, S Hirayama, T Ito, H Chiba, T Miida |
Metabolism | 2011 |
Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy
JE McLaren, DR Michael, TG Ashlin, DP Ramji |
Progress in Lipid Research | 2011 |
Class B scavenger receptor, Croquemort from kuruma shrimp Marsupenaeus japonicus: Molecular cloning and characterization
T Mekata, S Okugawa, M Inada, M Yoshimine, J Nishi, T Kono, M Sakai, T Itami, R Sudhakaran |
Molecular and Cellular Probes | 2011 |
Pivotal Role for Platelet-Activating Factor Receptor in CD36 Expression and oxLDL Uptake by Human Monocytes/Macrophages
FJ Rios, M Gidlund, S Jancar |
Cellular Physiology and Biochemistry | 2011 |
Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells
R Madonna, S Salerni, D Schiavone, JF Glatz, YJ Geng, RD Caterina |
Thrombosis and Haemostasis | 2011 |
Electrospray MS/MS reveals extensive and nonspecific oxidation of cholesterol esters in human peripheral vascular lesions[S]
PM Hutchins, EE Moore, RC Murphy |
Journal of lipid research | 2011 |
Vav Family Rho Guanine Nucleotide Exchange Factors Regulate CD36-mediated Macrophage Foam Cell Formation
SO Rahaman, W Swat, M Febbraio, RL Silverstein |
The Journal of biological chemistry | 2011 |
Serum Amyloid A Activates the NLRP3 Inflammasome via P2X 7 Receptor and a Cathepsin B-Sensitive Pathway
K Niemi, L Teirilä, J Lappalainen, K Rajamäki, MH Baumann, K Öörni, H Wolff, PT Kovanen, S Matikainen, KK Eklund |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
The role of CD4+CD25+ regulatory T cells in macrophage-derived foam-cell formation
J Lin, M Li, Z Wang, S He, X Ma, D Li |
Journal of lipid research | 2010 |
oxHDL decreases the expression of CD36 on human macrophages through PPARγ and p38 MAP kinase dependent mechanisms
J Ren, W Jin, H Chen |
Molecular and Cellular Biochemistry | 2010 |
COX-2 Inhibition and Inhibition of Cytosolic Phospholipase A2 Increase CD36 Expression and Foam Cell Formation in THP-1 Cells
K Anwar, I Voloshyna, MJ Littlefield, SE Carsons, PA Wirkowski, NL Jaber, A Sohn, S Eapen, AB Reiss |
Lipids | 2010 |
How can high-throughput screening deliver drugs to treat atherosclerosis?
Y Yang, L Wang, S Si, B Hong |
Expert Opinion on Drug Discovery | 2010 |
Regulation of Platelet Function by Class B Scavenger Receptors in Hyperlipidemia
A Zimman, EA Podrez |
Arteriosclerosis, thrombosis, and vascular biology | 2010 |
Discovery of Antagonists for Human Scavenger Receptor CD36 via an ELISA-Like High-Throughput Screening Assay
L Wang, Y Bao, Y Yang, Y Wu, X Chen, S Si, B Hong |
Journal of biomolecular screening | 2010 |
Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat
J Pang, Q Xu, X Xu, H Yin, R Xu, S Guo, W Hao, L Wang, C Chen, JM Cao |
Peptides | 2010 |
Serum soluble CD36, assessed by a novel monoclonal antibody-based sandwich ELISA, predicts cardiovascular mortality in dialysis patients
M Chmielewski, AC Bragfors-Helin, P Stenvinkel, B Lindholm, B Anderstam |
Clinica Chimica Acta | 2010 |
Vitamin D regulates macrophage cholesterol metabolism in diabetes
AE Riek, J Oh, C Bernal-Mizrachi |
The Journal of Steroid Biochemistry and Molecular Biology | 2010 |
Traité de médecine vasculaire
I Brochériou |
Traité de médecine vasculaire. | 2010 |
Differential Trafficking of Oxidized LDL and Oxidized LDL Immune Complexes in Macrophages: Impact on Oxidative Stress
MM Gadban, KJ Smith, F Soodavar, C Piansay, C Chassereau, WO Twal, RL Klein, G Virella, MF Lopes-Virella, SM Hammad, J Kanellopoulos |
PloS one | 2010 |
A BRIEF COMMUNICATION: Enhanced CD36 Scavenger Receptor Expression in THP-1 Human Monocytes in the Presence of Lupus Plasma: Linking Autoimmunity and Atherosclerosis
AB Reiss, DW Wan, K Anwar, JT Merrill, PA Wirkowski, N Shah, BN Cronstein, ES Chan, SE Carsons |
Experimental biology and medicine (Maywood, N.J.) | 2009 |
Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1
Q Kang, A Chen |
Laboratory Investigation | 2009 |
Expression of caveolin-1 in hepatic cells increases oxidized LDL uptake and preserves the expression of lipoprotein receptors
TQ Truong, MR Brodeur, L Falstrault, D Rhainds, L Brissette |
Journal of Cellular Biochemistry | 2009 |
Medical bioremediation of age-related diseases
JM Mathieu, J Schloendorn, BE Rittmann, PJ Alvarez |
Microbial cell factories | 2009 |
Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis
RF Collins, N Touret, H Kuwata, NN Tandon, S Grinstein, WS Trimble |
The Journal of biological chemistry | 2009 |
CD36: promotion from scavenger receptor to mediator of migration?
C Erridge |
Cardiovascular Research | 2009 |
High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance
J Xue, Z Yuan, Y Wu, Y Liu, Y Zhao, W Zhang, Y Tian, W Liu, Y Liu, C Kishimoto |
Cardiovascular Research | 2009 |
The role of CD4+CD25+ regulatory T cells in macrophage-derived foam-cell formation
J Lin, M Li, Z Wang, S He, X Ma, D Li |
Journal of lipid research | 2009 |
CD36 modulates macrophage migration in response to oxidized LDL and contributes to macrophage trapping
Young Mi Park, Maria Febbraio, and Roy L. Silverstein |
Journal of Clinical Investigation | 2008 |
Hexarelin Signaling to PPARγ in Metabolic Diseases
A Demers, A Rodrigue-Way, A Tremblay |
PPAR Research | 2008 |
Pioglitazone promotes peripheral nerve remyelination after crush injury through CD36 upregulation
M Eto, H Sumi, H Fujimura, H Yoshikawa, S Sakoda |
Journal of the Peripheral Nervous System | 2008 |
Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells
MR Brodeur, L Brissette, L Falstrault, P Ouellet, R Moreau |
Free radical biology & medicine | 2008 |
CD36 mRNA EXPRESSION IS INCREASED IN CD14+MONOCYTES OF PATIENTS WITH CORONARY HEART DISEASE
D Teupser, MA Mueller, J Koglin, W Wilfert, J Ernst, W Scheidt, G Steinbeck, D Seidel, J Thiery |
Clinical and Experimental Pharmacology and Physiology | 2008 |
Effect of niacin on adipocyte leptin in hypercholesterolemic rabbits
J Yang, S Zhao, J Li, S Dong |
Cardiovascular Pathology | 2008 |
Molecular basis of human CD36 gene mutations
ME Rać, K Safranow, W Poncyljusz |
Molecular Medicine | 2007 |
Tumor necrosis factor alpha and adalimumab differentially regulate CD36 expression in human monocytes
JF Boyer, P Balard, H Authier, B Faucon, J Bernad, B Mazières, JL Davignon, A Cantagrel, B Pipy, A Constantin |
Arthritis Research & Therapy | 2007 |
Conformation of an Endogenous Ligand in a Membrane Bilayer for the Macrophage Scavenger Receptor CD36
XM Li, RG Salomon, J Qin, SL Hazen |
Biochemistry | 2007 |
Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
EY Chung, J Liu, Y Homma, Y Zhang, A Brendolan, M Saggese, J Han, R Silverstein, L Selleri, X Ma |
Immunity | 2007 |
Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention
A Munteanu, JM Zingg |
Molecular Aspects of Medicine | 2007 |
Scavenger Receptor of Class B Expressed by Osteoblastic Cells Are Implicated in the Uptake of Cholesteryl Ester and Estradiol From LDL and HDL3
MR Brodeur, L Brissette, L Falstrault, V Luangrath, R Moreau |
Journal of Bone and Mineral Research | 2007 |
Measurement of Plasma Oxidized Low-Density Lipoprotein and its Clinical Implications
H Itabe, M Ueda |
Journal of Atherosclerosis and Thrombosis | 2007 |
El monocito/macrófago como diana terapéutica en la aterosclerosis
J Pou, A Rebollo, M Alegret |
Clínica e Investigación en Arteriosclerosis | 2007 |
IL-13 induces expression of CD36 in human monocytes through PPARgamma activation
A Berry, P Balard, A Coste, D Olagnier, C Lagane, H Authier, F Benoit-Vical, JC Lepert, JP Séguéla, JF Magnaval, P Chambon, D Metzger, B Desvergne, W Wahli, J Auwerx, B Pipy |
European Journal of Immunology | 2007 |
Identification of a Serum Component That Regulates Cyclooxygenase-2 Gene Expression in Cooperation with 4-Hydroxy-2-nonenal
M Kanayama, S Yamaguchi, T Shibata, N Shibata, M Kobayashi, R Nagai, H Arai, K Takahashi, K Uchida |
The Journal of biological chemistry | 2007 |
Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI
B Sun, BB Boyanovsky, MA Connelly, P Shridas, DR van der Westhuyzen, NR Webb |
Journal of lipid research | 2007 |
Molecular basis of human CD36 gene mutations.
Rać ME, Safranow K, Poncyljusz W |
Molecular Medicine | 2007 |
Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients
S Yamashita, KI Hirano, T Kuwasako, M Janabi, Y Toyama, M Ishigami, N Sakai |
Molecular and Cellular Biochemistry | 2006 |
Is there an association between angiotensin-converting enzyme gene polymorphism and functional activation of monocytes and macrophage in young patients with essential hypertension?
D Zapolska-Downar, A Siennicka, K Chełstowski, K Widecka, I Gorący, M Hałasa, B Machaliński, M Naruszewicz |
Journal of Hypertension | 2006 |
In vivo cholesteryl ester selective uptake of mildly and standardly oxidized LDL occurs by both parenchymal and nonparenchymal mouse hepatic cells but SR-BI is only responsible for standardly oxidized LDL selective uptake by nonparenchymal cells
G Bourret, MR Brodeur, V Luangrath, J Lapointe, L Falstrault, L Brissette |
The International Journal of Biochemistry & Cell Biology | 2006 |
The association between CD36 and Lyn protein tyrosine kinase is mediated by lipid
RF Thorne, EG Law, CA Elith, KJ Ralston, RC Bates, GF Burns |
Biochemical and Biophysical Research Communications | 2006 |
PPARγ activation induces CD36 expression and stimulates foam cell like changes in rVSMCs
HJ Lim, S Lee, KS Lee, JH Park, Y Jang, EJ Lee, HY Park |
Prostaglandins & Other Lipid Mediators | 2006 |
Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages
Y Luan, HR Griffiths |
Archives of Biochemistry and Biophysics | 2006 |
Phospholipid Hydroxyalkenals, a Subset of Recently Discovered Endogenous CD36 Ligands, Spontaneously Generate Novel Furan-containing Phospholipids Lacking CD36 Binding Activity in Vivo
S Gao, R Zhang, ME Greenberg, M Sun, X Chen, BS Levison, RG Salomon, SL Hazen |
The Journal of biological chemistry | 2006 |
Antagonistic Effects of Oxidized Low Density Lipoprotein and α-Tocopherol on CD36 Scavenger Receptor Expression in Monocytes: INVOLVEMENT OF PROTEIN KINASE B AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ
A Munteanu, M Taddei, I Tamburini, E Bergamini, A Azzi, JM Zingg |
The Journal of biological chemistry | 2006 |
RUNX3 Negatively Regulates CD36 Expression in Myeloid Cell Lines
A Puig-Kröger, A Domínguez-Soto, L Martínez-Muñoz, D Serrano-Gómez, M Lopez-Bravo, E Sierra-Filardi, E Fernández-Ruiz, N Ruiz-Velasco, C Ardavín, Y Groner, N Tandon, AL Corbí, MA Vega |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Light-induced Oxidation of Photoreceptor Outer Segment Phospholipids Generates Ligands for CD36-mediated Phagocytosis by Retinal Pigment Epithelium
M Sun, SC Finnemann, M Febbraio, L Shan, SP Annangudi, EA Podrez, G Hoppe, R Darrow, DT Organisciak, RG Salomon, RL Silverstein, SL Hazen |
The Journal of biological chemistry | 2005 |
CD36:A Multiligand Molecule
Y Ge, MT Elghetany |
Laboratory Hematology | 2005 |
Expression of Scavenger Receptor CD36 in Chronic Renal Failure Patients
M Chmielewski, E Bryl, L Marzec, E Aleksandrowicz, JM Witkowski, B Rutkowski |
Artificial Organs | 2005 |
Glycolaldehyde-Modified Bovine Serum Albumin Downregulates Leptin Expression in Mouse Adipocytes via a CD36-Mediated Pathway
Y Unno, M Sakai, YI Sakamoto, A Kuniyasu, R Nagai, H Nakayama, S Horiuchi |
Annals of the New York Academy of Sciences | 2005 |
CD36 Is Not Involved in Scavenger Receptor–Mediated Endocytic Uptake of Glycolaldehyde- and Methylglyoxal-Modified Proteins by Liver Endothelial Cells
K Nakajou, S Horiuchi, M Sakai, K Hirata, M Tanaka, M Takeya, T Kai, M Otagiri |
Journal of Biochemistry | 2005 |
Increased Risk of Colorectal Cancer Due to Interactions Between Meat Consumption and the CD36 Gene A52C Polymorphism Among Japanese
K Kuriki, N Hamajima, H Chiba, Y Kanemitsu, T Hirai, T Kato, T Saito, K Matsuo, K Koike, S Tokudome, K Tajima |
Nutrition and Cancer | 2005 |
Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages
B Fuhrman, N Volkova, M Aviram |
The Journal of Nutritional Biochemistry | 2005 |
Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis
AS Antonov, FD Kolodgie, DH Munn, RG Gerrity |
The American Journal of Pathology | 2004 |
Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36
Y Unno, M Sakai, Y Sakamoto, A Kuniyasu, H Nakayama, R Nagai, S Horiuchi |
Biochemical and Biophysical Research Communications | 2004 |
The role of scavenger receptor class B type I (SR-BI) in lipid trafficking
D Rhainds, L Brissette |
The International Journal of Biochemistry & Cell Biology | 2004 |
Normal and pathological human testes express hormone-sensitive lipase and the lipid receptors CLA-1/SR-BI and CD36
MI Arenas, MV Lobo, E Caso, L Huerta, R Paniagua, MA Martı́n-Hidalgo |
Human Pathology | 2004 |
Expression of CD36 in Macrophages and Atherosclerosis The Role of Lipid Regulation of PPARγ Signaling
AC Nicholson |
Trends in Cardiovascular Medicine | 2004 |
Atorvastatin enhances cellular uptake of oxidized LDL in adipocytes from hypercholesterolemic rabbits
SP Zhao, DQ Zhang |
Clinica Chimica Acta | 2004 |
CD36, oxidized LDL and PPARγ: pathological interactions in macrophages and atherosclerosis
AC Nicholson, DP Hajjar |
Vascular Pharmacology | 2004 |
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-γ ligands Putative contribution of Rho GTPases in statin-induced CD36 expression
N Ruiz-Velasco, A Domı́nguez, MA Vega |
Biochemical Pharmacology | 2004 |
Expression of Class A Scavenger Receptor Is Enhanced by High Glucose in Vitro and under Diabetic Conditions in Vivo: ONE MECHANISM FOR AN INCREASED RATE OF ATHEROSCLEROSIS IN DIABETES
K Fukuhara-Takaki, M Sakai, Y Sakamoto, M Takeya, S Horiuchi |
The Journal of biological chemistry | 2004 |
Role of Oxidative Modifications in Atherosclerosis
R Stocker, JF Keaney |
Physiological reviews | 2004 |
HIV Protease Inhibitors Promote Atherosclerotic Lesion Formation Independent of Dyslipidemia by Increasing CD36-Dependent Cholesteryl Ester Accumulation in Macrophages
James Dressman Jeanie Kincer Sergey V. Matveev Ling Guo Richard N. Greenberg Theresa Guerin David Meade Xiang-An Li Weifei Zhu Annette Uittenbogaard Melinda E. Wilson Eric J. Smart |
Journal of Clinical Investigation | 2003 |
The Role of Human and Mouse Hepatic Scavenger Receptor Class B Type I (SR-BI) in the Selective Uptake of Low-Density Lipoprotein−Cholesteryl Esters
D Rhainds, M Brodeur, J Lapointe, D Charpentier, L Falstrault, L Brissette |
Biochemistry | 2003 |
Phospholipids in oxidized LDL not adducted to apoB are recognized by the CD36 scavenger receptor
EA Podrez, G Hoppe, J O’Neil, HF Hoff |
Free radical biology & medicine | 2003 |
The role of CD36 in peripheral nerve remyelination after crush injury
M Eto, H Yoshikawa, H Fujimura, I Naba, H Sumi-Akamaru, S Takayasu, H Itabe, S Sakoda |
European Journal of Neuroscience | 2003 |
Oxidized Low-density Lipoproteins: What Is Understood and What Remains to Be Clarified
H Itabe |
Biological & Pharmaceutical Bulletin | 2003 |
Unsaturated fatty acids and their oxidation products stimulate CD36 expression in human macrophages
JC Vallvé, K Uliaque, J Girona, A Cabré, J Ribalta, M Heras, L Massana, M Alegret |
Clínica e Investigación en Arteriosclerosis | 2003 |
Molecular Mechanisms of Atherogenesis and Restenosis : Possible Roles of Oxidized LDL and Oxidized LDL Receptors
N Kume |
Japanese Journal of Neurosurgery | 2003 |
Endocytosis of Oxidized Low Density Lipoprotein through Scavenger Receptor CD36 Utilizes a Lipid Raft Pathway That Does Not Require Caveolin-1
Y Zeng, N Tao, KN Chung, JE Heuser, DM Lublin |
The Journal of biological chemistry | 2003 |
The Macrophage as Therapeutic Target
S Gordon |
2003 | |
Novel 5' exon of scavenger receptor CD36 is expressed in cultured human vascular smooth muscle cells and atherosclerotic plaques
JM Zingg, R Ricciarelli, E Andorno, A Azzi |
Arteriosclerosis, thrombosis, and vascular biology | 2002 |
Oxidized phosphatidylcholines: pattern recognition ligands for multiple pathways of the innate immune response
SL Hazen, GM Chisolm |
Proceedings of the National Academy of Sciences | 2002 |
Peroxisome-proliferator-activated-receptor gamma (PPARgamma) independent induction of CD36 in THP-1 monocytes by retinoic acid
S Han, N Sidell |
Immunology | 2002 |
CD36 mRNA and Protein Expression Levels Are Significantly Increased in the Heart and Testis of apoE Deficient Mice in Comparison to Wild Type (C57BL/6)
K Zibara, E Malaud, JL McGregor |
Journal of Biomedicine and Biotechnology | 2002 |
Expression of Lipoprotein Receptors in the Aortic Walls of Diabetic APA hamsters
J YAMANOUCHI, A TAKATORI, E NISHIDA, S KAWAMURA, Y YOSHIKAWA |
Experimental Animals | 2002 |
Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL
M Zhao, Y Liu, X Wang, L New, J Han, UT Brunk |
APMIS | 2002 |
Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase
B Fuhrman, N Volkova, M Aviram |
Atherosclerosis | 2002 |
CD36 deficiency induced by antiretroviral therapy
L Serghides, S Nathoo, S Walmsley, KC Kain |
AIDS | 2002 |
The Class A Scavenger Receptor Binds to Proteoglycans and Mediates Adhesion of Macrophages to the Extracellular Matrix
J Santiago-Garcı́a, T Kodama, RE Pitas |
The Journal of biological chemistry | 2002 |
Angiotensin II administration to atherosclerotic mice increases macrophage uptake of oxidized ldl: a possible role for interleukin-6
S Keidar, R Heinrich, M Kaplan, T Hayek, M Aviram |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Japanese Journal of Thrombosis and Hemostasis
M OKUDAIRA, H ASAKURA, Y SANO, Y SUGA, M YAMAZAKI, K AOSHIMA, E MORISHITA, M SAITO, Y ONTACHI, T MIZUTANI, M KATO, T ITO, K MIYAMOTO, S NAKAO |
Japanese Journal of Thrombosis and Hemostasis | 2001 |
C-terminal fragment of α1-antitrypsin activates human monocytes to a pro-inflammatory state through interactions with the CD36 scavenger receptor and LDL receptor
S Janciauskiene, F Moraga, S Lindgren |
Atherosclerosis | 2001 |
Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36
RA Guy, GF Maguire, I Crandall, PW Connelly, KC Kain |
Atherosclerosis | 2001 |
Erythroid involvement in CD36 deficiency
K Toba, H Hanawa, K Watanabe, I Fuse, M Masuko, S Miyajima, M Takahashi, M Sakaue, T Abo, Y Aizawa |
Experimental Hematology | 2001 |
Role of CD36, the Macrophage Class B Scavenger Receptor, in Atherosclerosis
AC Nicholson, J Han, M Febbraio, RL Silversterin, DP Hajjar |
Annals of the New York Academy of Sciences | 2001 |
A patient with type I CD36 deficiency whose myocardium accumulated123I-BMIPP after 4 years
K Ito, H Sugihara, T Tanabe, K Zen, T Hikosaka, Y Adachi, S Katoh, A Azuma, M Nakagawa |
Annals of Nuclear Medicine | 2001 |
Localization of CD36 and scavenger receptor class A in human coronary arteries — a possible difference in the contribution of both receptors to plaque formation
Y Nakagawa-Toyama |
Atherosclerosis | 2001 |
Reduced Adhesion of Monocyte-Derived Macrophages from CD36-Deficient Patients to Type I Collagen
M Janabi, S Yamashita, K Hirano, K Matsumoto, N Sakai, H Hiraoka, H Kashiwagi, Y Tomiyama, S Nozaki, Y Matsuzawa |
Biochemical and Biophysical Research Communications | 2001 |
Atherosclerosis and Autoimmunity
EC Lau |
Atherosclerosis and Autoimmunity | 2001 |
Carbon Monoxide and Cardiovascular Functions
R Johnson, F Johnson |
Carbon Monoxide and Cardiovascular Functions | 2001 |
Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
N Ouchi, S Kihara, Y Arita, M Nishida, A Matsuyama, Y Okamoto, M Ishigami, H Kuriyama, K Kishida, H Nishizawa, K Hotta, M Muraguchi, Y Ohmoto, S Yamashita, T Funahashi, Y Matsuzawa |
Circulation | 2001 |
A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation
E Griffin, A Re, N Hamel, C Fu, H Bush, T McCaffrey, AS Asch |
Nature Medicine | 2001 |
Localization of the Lipid Receptors CD36 and CLA-1/SR-BI in the Human Gastrointestinal Tract: Towards the Identification of Receptors Mediating the Intestinal Absorption of Dietary Lipids
MV Lobo, L Huerta, N RuizVelasco, E Teixeiro, P la Cueva, A Celdrán, A MartínHidalgo, MA Vega, R Bragado |
Journal of Histochemistry & Cytochemistry | 2001 |
Binding and uptake of differently oxidized low density lipoprotein in mouse peritoneal macrophages and THP-1 macrophages: Involvement of negative charges as well as oxidation-specific epitopes
X Wang, J Greilberger, G Ledinski, G Kager, G Jrgens |
Journal of Cellular Biochemistry | 2001 |
Secreted Forms of the Amyloid-β Precursor Protein Are Ligands for the Class A Scavenger Receptor
J Santiago-Garcı́a, J Mas-Oliva, TL Innerarity, RE Pitas |
The Journal of biological chemistry | 2001 |
Troglitazone Inhibits Atherosclerosis in Apolipoprotein E–Knockout Mice: Pleiotropic Effects on CD36 Expression and HDL
Z Chen, S Ishibashi, S Perrey, J Osuga, T Gotoda, T Kitamine, Y Tamura, H Okazaki, N Yahagi, Y Iizuka, F Shionoiri, K Ohashi, K Harada, H Shimano, R Nagai, N Yamada |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
12/15-Lipoxygenase Gene Disruption Attenuates Atherogenesis in LDL Receptor–Deficient Mice
J George, A Afek, A Shaish, H Levkovitz, N Bloom, T Cyrus, L Zhao, CD Funk, E Sigal, D Harats |
Circulation | 2001 |
Induction of CD36 by all‐trans retinoic acid: retinoic acid receptor signaling in the pathogenesis of atherosclerosis
DM Wuttge, A Romert, U Eriksson, H Törmä, GK Hansson, A Sirsjö |
The FASEB Journal | 2001 |
α-Tocopherol decreases CD36 expression in human monocyte-derived macrophages
S Devaraj, I Hugou, I Jialal |
Journal of lipid research | 2001 |
CD36 does not play a direct role in HDL or LDL metabolism
WJ de Villiers, L Cai, NR Webb, MC de Beer, DR van der Westhuyzen, FC de Beer |
Journal of lipid research | 2001 |
Targeted disruption of the class B scavenger receptor, CD36, protects against atherosclerotic lesion development in mice
Maria Febbraio, Eugene A. Podrez, Jonathan Smith, David P. Hajjar, Stanley L. Hazen, Henry F. Hoff, Kavita Sharma, Roy L. Silverstein |
Journal of Clinical Investigation | 2000 |
Oxidized low density lipoprotein reduces monocyte CCR2 expression through pathways that involve activation of peroxisome proliferator-activated receptor gamma (PPARgamma)
Ki Hoon Han, Mi Kyung Chang, Agnes Boullier, Simone R. Green, Andrew Li, Christopher K. Glass, Oswald Quehenberger |
Journal of Clinical Investigation | 2000 |
Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
EA Podrez, M Febbraio, N Sheibani, D Schmitt, RL Silverstein, DP Hajjar, PA Cohen, WA Frazier, HF Hoff, SL Hazen |
Journal of Clinical Investigation | 2000 |
Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol
H Yanai, H Chiba, M Morimoto, K Abe, H Fujiwara, H Fuda, SP Hui, Y Takahashi, H Akita, GA Jamieson, K Kobayashi, K Matsuno |
American Journal of Medical Genetics | 2000 |
Regulation of fatty acid transporters in mammalian cells
BI Frohnert, DA Bernlohr |
Progress in Lipid Research | 2000 |
Scavenger receptor regulation and atherosclerosis
JM Zingg, R Ricciarelli, A Azzi |
BioFactors | 2000 |
Losartan Inhibits Cellular Uptake of Oxidized LDL by Monocyte-Macrophages from Hypercholesterolemic Patients
T Hayek, M Aviram, R Heinrich, E Sakhnini, S Keidar |
Biochemical and Biophysical Research Communications | 2000 |
CD36 and atherosclerosis
RL Silverstein, M Febbraio |
Current Opinion in Lipidology | 2000 |
Advanced Glycation End Products-Induced Gene Expression of Scavenger Receptors in Cultured Human Monocyte-Derived Macrophages
Y Iwashima, M Eto, A Hata, K Kaku, S Horiuchi, F Ushikubi, H Sano |
Biochemical and Biophysical Research Communications | 2000 |
Apoptosis induced by oxidized low density lipoprotein in human monocyte-derived macrophages involves CD36 and activation of caspase-3
ES Wintergerst, J Jelk, C Rahner, R Asmis |
European Journal of Biochemistry | 2000 |
Fatty Acid Transport Regulatory Proteins in the Developing Rat Placenta and in Trophoblast Cell Culture Models
GT Knipp, B Liu, KL Audus, H Fujii, T Ono, MJ Soares |
Placenta | 2000 |
PS-Liposome and Ox-LDL Bind to Different Sites of the Immunodominant Domain (#155-183) of CD36
A Yamaguchi, N Yamamoto, N Akamatsu, TC Saido, M Kaneda, M Umeda, K Tanoue |
Thrombosis Research | 2000 |
The Adhesion Molecule FactsBook
CM Isacke, MA Horton |
The Adhesion Molecule FactsBook | 2000 |
The Binding of Oxidized Low Density Lipoprotein to Mouse CD36 Is Mediated in Part by Oxidized Phospholipids That Are Associated with Both the Lipid and Protein Moieties of the Lipoprotein
A Boullier, KL Gillotte, S Hörkkö, SR Green, P Friedman, EA Dennis, JL Witztum, D Steinberg, O Quehenberger |
The Journal of biological chemistry | 2000 |
CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products
N Ohgami, R Nagai, M Ikemoto, H Arai, A Kuniyasu, S Horiuchi, H Nakayama |
The Journal of biological chemistry | 2000 |
TGF-β1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages
G Draude, RL Lorenz |
American journal of physiology. Heart and circulatory physiology | 2000 |
Vitamin E Reduces the Uptake of Oxidized LDL by Inhibiting CD36 Scavenger Receptor Expression in Cultured Aortic Smooth Muscle Cells
R Ricciarelli, JM Zingg, A Azzi |
Circulation | 2000 |
Hepatic and Extrahepatic Scavenger Receptors: Function in Relation to Disease
V Terpstra, ES van Amersfoort, AG van Velzen, J Kuiper, TJ van Berkel |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Expression of Macrophage (Mφ) Scavenger Receptor, CD36, in Cultured Human Aortic Smooth Muscle Cells in Association With Expression of Peroxisome Proliferator Activated Receptor-γ, Which Regulates Gain of Mφ-Like Phenotype In Vitro, and Its Implication in Atherogenesis
K Matsumoto, K Hirano, S Nozaki, A Takamoto, M Nishida, Y Nakagawa-Toyama, MY Janabi, T Ohya, S Yamashita, Y Matsuzawa |
Arteriosclerosis, thrombosis, and vascular biology | 2000 |
Oxidative Stress and Vascular Disease
JF Keaney |
2000 | |
Lipoprotein Metabolism and Atherogenesis
T Kita, M Yokode |
2000 | |
Macrophage receptors responsible for distinct recognition of low density lipoprotein containing pyrrole or pyridinium adducts: models of oxidized low density lipoprotein
EA Podrez, G Hoppe, J O'Neil, LM Sayre, N Sheibani, HF Hoff |
Journal of lipid research | 2000 |
Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-γ
J Feng, J Han, SF Pearce, RL Silverstein, AM Gotto, DP Hajjar, AC Nicholson |
Journal of lipid research | 2000 |
Apoptotic Thymocyte Clearance in Scavenger Receptor Class A-Deficient Mice Is Apparently Normal
N Platt, H Suzuki, T Kodama, S Gordon |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
The Role of Scavenger Receptor Class A in the Adhesion of Cells Is Dependent on Cell Type and Cellular Activation State
W Ling, M Lougheed, H Suzuki, A Buchan, T Kodama, UP Steinbrecher |
Journal of Clinical Investigation | 1999 |
Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice
T Cyrus, JL Witztum, DJ Rader, R Tangirala, S Fazio, MF Linton, CD Funk |
Journal of Clinical Investigation | 1999 |
Uptake and fate of class B scavenger receptor ligands in HepG2 cells
D Rhainds, L Falstrault, C Tremblay, L Brissette |
European Journal of Biochemistry | 1999 |
Scavenger receptors and oxidized low density lipoproteins
BS Dhaliwal, UP Steinbrecher |
Clinica Chimica Acta | 1999 |
Nutrient transport across the placenta
GT Knipp, KL Audus, MJ Soares |
Advanced Drug Delivery Reviews | 1999 |
Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells
DA Bird, KL Gillotte, S Hörkkö, P Friedman, EA Dennis, JL Witztum, D Steinberg |
Proceedings of the National Academy of Sciences | 1999 |
Low density lipoprotein uptake: holoparticle and cholesteryl ester selective uptake
D Rhainds, L Brissette |
The International Journal of Biochemistry & Cell Biology | 1999 |
Activation of monocytes in vivo causes intracellular accumulation of lipoprotein-derived lipids and marked hypocholesterolemia—a possible pathogenesis of necrobiotic xanthogranuloma
F Matsuura, S Yamashita, K Hirano, M Ishigami, H Hiraoka, R Tamura, T Nakagawa, M Nishida, N Sakai, T Nakamura, S Nozaki, T Funahashi, C Matsumoto, M Higashiyama, K Yoshikawa, Y Matsuzawa |
Atherosclerosis | 1999 |
Regulation of macrophage gene expression by peroxisome-proliferator-activated receptor y
P Tontonoz, L Nagy |
Current Opinion in Lipidology | 1999 |
Time-Resolved Fluorometric Assay for Measuring Cell Binding and Association of Native and Oxidized Low-Density Lipoproteins to Macrophages
X Wang, J Greilberger, G Jürgens |
Analytical Biochemistry | 1999 |
Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells
DA Bird, KL Gillotte, S Horkko, P Friedman, EA Dennis, JL Witztum, D Steinberg |
Proceedings of the National Academy of Sciences | 1999 |
The Role of Scavenger Receptor Class A in the Adhesion of Cells Is Dependent on Cell Type and Cellular Activation State
W Ling, M Lougheed, H Suzuki, A Buchan, T Kodama, UP Steinbrecher |
Experimental Cell Research | 1999 |
Human platelets exclusively bind oxidized low density lipoprotein showing no specificity for acetylated low density lipoprotein
I Volf, T Moeslinger, J Cooper, W Schmid, E Koller |
FEBS Letters | 1999 |
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions
H Kataoka, N Kume, S Miyamoto, M Minami, H Moriwaki, T Murase, T Sawamura, T Masaki, N Hashimoto, T Kita |
Circulation | 1999 |
A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism
M Febbraio, NA Abumrad, DP Hajjar, K Sharma, W Cheng, SF Pearce, RL Silverstein |
The Journal of biological chemistry | 1999 |
The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin
G Draude, N Hrboticky, RL Lorenz |
Biochemical Pharmacology | 1999 |
Specific interaction of oxidized low-density lipoprotein with macrophage-derived foam cells isolated from rabbit atherosclerotic lesions
H E de Vries, B Buchner, T J van Berkel, J Kuiper |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Receptors for oxidized low density lipoprotein
UP Steinbrecher |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 1999 |
Distinct scavenger receptor expression and function in the human CD14 + /CD16 + monocyte subset
G Draude, P Hundelshausen, M Frankenberger, HW Ziegler-Heitbrock, C Weber |
American journal of physiology. Heart and circulatory physiology | 1999 |
CD36, a Novel Receptor for Oxidized Low-Density Lipoproteins, Is Highly Expressed on Lipid-Laden Macrophages in Human Atherosclerotic Aorta
A Nakata, Y Nakagawa, M Nishida, S Nozaki, J Miyagawa, T Nakagawa, R Tamura, K Matsumoto, K Kameda-Takemura, S Yamashita, Y Matsuzawa |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Expression of Human Scavenger Receptor Class B Type I in Cultured Human Monocyte-Derived Macrophages and Atherosclerotic Lesions
K Hirano, S Yamashita, Y Nakagawa, T Ohya, F Matsuura, K Tsukamoto, Y Okamoto, A Matsuyama, K Matsumoto, J Miyagawa, Y Matsuzawa |
Circulation research | 1999 |
Uptake of Oxidized LDL by Macrophages Differs From That of Acetyl LDL and Leads to Expansion of an Acidic Endolysosomal Compartment
M Lougheed, ED Moore, DR Scriven, UP Steinbrecher |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Lovastatin Decreases the Receptor-Mediated Degradation of Acetylated and Oxidized LDLs in Human Blood Monocytes During the Early Stage of Differentiation Into Macrophages
N Hrboticky, G Draude, G Hapfelmeier, R Lorenz, PC Weber |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Requirement for Croquemort in Phagocytosis of Apoptotic Cells in Drosophila
NC Franc, P Heitzler, RA B., Ezekowitz, K White |
Science | 1999 |
Mechanisms of cellular uptake of long chain free fatty acids
P D Berk, D D Stump |
Molecular and Cellular Biochemistry | 1999 |
CD36 antisense expression in 3T3-F442A preadipocytes
Z Sfeir, A Ibrahimi, E Amri, P Grimaldi, N Abumrad |
Molecular and Cellular Biochemistry | 1999 |
Oxidized phospholipids as a new landmark in atherosclerosis
H Itabe |
Progress in Lipid Research | 1998 |
Expression of lipoprotein receptors in atherosclerotic lesions
TP Hiltunen, S Ylä-Herttuala |
Atherosclerosis | 1998 |
Myocardial CD36 expression and fatty acid accumulation in patients with type I and II CD36 deficiency
K Watanabe, Y Ohta, K Toba, Y Ogawa, H Hanawa, Y Hirokawa, M Kodama, N Tanabe, S Hirono, Y Ohkura, Y Nakamura, K Kato, Y Aizawa, I Fuse, S Miyajima, Y Kusano, T Nagamoto, G Hasegawa, M Naito |
Annals of Nuclear Medicine | 1998 |
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
L Nagy, P Tontonoz, JG Alvarez, H Chen, RM Evans |
Cell | 1998 |
Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor
H Yoshida, N Kondratenko, S Green, D Steinberg, O Quehenberger |
Biochemical Journal | 1998 |
Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors
V Terpstra, DA Bird, D Steinberg |
Proceedings of the National Academy of Sciences | 1998 |
Complementary roles for scavenger receptor A and CD36 of human monocyte-derived macrophages in adhesion to surfaces coated with oxidized low-density lipoproteins and in secretion of H2O2
H Maxeiner, J Husemann, CA Thomas, JD Loike, JE Khoury, SC Silverstein |
Journal of Experimental Medicine | 1998 |
Complementary Roles for Scavenger Receptor A and CD36 of Human Monocyte-derived Macrophages in Adhesion to Surfaces Coated with Oxidized Low-Density Lipoproteins and in Secretion of H2O2
H Maxeiner, J Husemann, CA Thomas, JD Loike, JE Khoury, SC Silverstein |
Journal of Experimental Medicine | 1998 |
Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-α
H Moriwaki, N Kume, H Kataoka, T Murase, E Nishi, T Sawamura, T Masaki, T Kita |
FEBS Letters | 1998 |
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
P Tontonoz, L Nagy, JG Alvarez, VA Thomazy, RM Evans |
Cell | 1998 |
Bases celulares y moleculares de la acumulación de colesterol en la pared vascular y su contribución a la progresión de la lesión aterosclerótica
V Llorente, L Badimon |
Revista Española de Cardiología | 1998 |
Oxidized LDL Increases and Interferon-γ Decreases Expression of CD36 in Human Monocyte–Derived Macrophages
T Nakagawa, S Nozaki, M Nishida, JM Yakub, Y Tomiyama, A Nakata, K Matsumoto, T Funahashi, K Kameda-Takemura, Y Kurata, S Yamashita, Y Matsuzawa |
Arteriosclerosis, thrombosis, and vascular biology | 1998 |
Minimally Oxidized Low-Density Lipoprotein Increases Expression of Scavenger Receptor A, CD36, and Macrosialin in Resident Mouse Peritoneal Macrophages
H Yoshida, O Quehenberger, N Kondratenko, S Green, D Steinberg |
Arteriosclerosis, thrombosis, and vascular biology | 1998 |
Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein
H Hakamata, A Miyazaki, M Sakai, H Matsuda, H Suzuki, T Kodama, S Horiuchi |
Journal of lipid research | 1998 |
Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
D Calvo, D Gómez-Coronado, Y Suárez, MA Lasunción, MA Vega |
Journal of lipid research | 1998 |
CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells
DW Dawson, SF Pearce, R Zhong, RL Silverstein, WA Frazier, NP Bouck |
The Journal of Cell Biology | 1997 |
Dietary antioxidants and cardioprotectionfact or fallacy?
UP Steinbrecher |
Canadian Journal of Physiology and Pharmacology | 1997 |
The Leucocyte Antigen FactsBook
AN Barclay, MH Brown, SK Law, AJ McKnight, MG Tomlinson, PA van der Merwe |
The Leucocyte Antigen FactsBook | 1997 |
High Affinity Saturable Uptake of Oxidized Low Density Lipoprotein by Macrophages from Mice Lacking the Scavenger Receptor Class A Type I/II
M Lougheed, CM Lum, W Ling, H Suzuki, T Kodama, U Steinbrecher |
The Journal of biological chemistry | 1997 |
Native and Modified Low Density Lipoproteins Increase the Functional Expression of the Macrophage Class B Scavenger Receptor, CD36
J Han, DP Hajjar, M Febbraio, AC Nicholson |
The Journal of biological chemistry | 1997 |
Independent Mechanisms for Macrophage Binding and Macrophage Phagocytosis of Damaged Erythrocytes: Evidence of Receptor Cooperativity
GR Sambrano, V Terpstra, D Steinberg |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
Lewis A. Conner Memorial Lecture: Oxidative Modification of LDL and Atherogenesis
D Steinberg |
Circulation | 1997 |
Human Monocyte–Derived Macrophages Express an ≈120-kD Ox-LDL Binding Protein With Strong Identity to CD68
MA van der Kooij, EM von der Mark, JK Kruijt, A van Velzen, TJ van Berkel, OH Morand |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
CLA-1 Is an 85-kD Plasma Membrane Glycoprotein That Acts as a High-Affinity Receptor for Both Native (HDL, LDL, and VLDL) and Modified (OxLDL and AcLDL) Lipoproteins
D Calvo, D Gómez-Coronado, MA Lasunción, MA Vega |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
Functional roles of membrane glycoprotein CD36
L Daviet, JL McGregor |
Platelets | 1996 |
Scavenger receptors in innate immunity
AM Pearson |
Current Opinion in Immunology | 1996 |
Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein
MP Ramprasad, V Terpstra, N Kondratenko, O Quehenberger, D Steinberg |
Proceedings of the National Academy of Sciences | 1996 |
To tell the truth: Will the real CD36 please stand up?
A Asch |
Journal of Laboratory and Clinical Medicine | 1996 |
Mechanism of Uptake of Copper-oxidized Low Density Lipoprotein in Macrophages Is Dependent on Its Extent of Oxidation
M Lougheed, UP Steinbrecher |
The Journal of biological chemistry | 1996 |
Regulation of Monocyte CD36 and Thrombospondin-1 Expression by Soluble Mediators
LM Yesner, HY Huh, SF Pearce, RL Silverstein |
Arteriosclerosis, thrombosis, and vascular biology | 1996 |
A Single Nucleotide Insertion in Codon 317 of the CD36 Gene Leads to CD36 Deficiency
H Kashiwagi, Y Tomiyama, S Nozaki, S Honda, S Kosugi, M Shiraga, T Nakagawa, N Nagao, Y Kanakura, Y Kurata, Y Matsuzawa |
Arteriosclerosis, thrombosis, and vascular biology | 1996 |
Drugs Affecting Lipid Metabolism
AM Gotto, R Paoletti, LC Smith, AL Catapano, AS Jackson |
1996 | |
Characterization of inherited scavenger receptor overexpression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthomas
C Giry, LM Giroux, M Roy, J Davignon, A Minnich |
Journal of lipid research | 1996 |
Charged collagen structure mediates the recognition of negatively charged macromolecules by macrophage scavenger receptors
N Platt, S Gordon |
The Journal of biological chemistry | 1993 |