Citations to this article

Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 (FGF-4) gene.
H Konishi, … , T Sugimura, M Terada
H Konishi, … , T Sugimura, M Terada
Published August 1, 1995
Citation Information: J Clin Invest. 1995;96(2):1125-1130. https://doi.org/10.1172/JCI118099.
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Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 (FGF-4) gene.

Abstract

HST-1 (FGF-4) gene product is a member of the fibroblast growth factor family with a signal peptide and plays a crucial role in limb development. We showed previously that an intraperitoneal injection of replication-deficient adenovirus containing the HST-1 gene (Adex1HST-1) into normal mice caused a twofold increase in peripheral platelet count. To investigate whether Adex1HST-1 could effectively prevent experimentally induced thrombocytopenia in mice, we injected Adex1HST-1 intraperitoneally into thrombocytopenic mice induced by administration of a chemotherapeutic agent and/or by irradiation. A single Adex1HST-1 injection caused continuously increased levels of serum HST-1 protein for at least 30 d and increased the count of large megakaryocytes in bone marrow, which specifically recovered platelet counts and more efficiently diminished the extent and duration of thrombocytopenia than any other reported cytokine or any combination of cytokines so far. In the other peripheral hematological parameters, no discernible differences were detected. No other apparent side effects were observed. Therefore, this method could be useful for treatment and/or prevention of thrombocytopenia induced by chemotherapy and/or irradiation for cancer treatment.

Authors

H Konishi, T Ochiya, H Sakamoto, M Tsukamoto, I Saito, T Muto, T Sugimura, M Terada

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Year: 2017 2013 2011 2008 2006 2004 2003 2002 2000 1999 1994 Total
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Citations to this article (17)

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Pleiotropic function of FGF-4: Its role in development and stem cells
N Kosaka, H Sakamoto, M Terada, T Ochiya 		Developmental Dynamics 2008
FGF-4 regulates neural progenitor cell proliferation and neuronal differentiation
N Kosaka, M Kodama, H Sasaki, Y Yamamoto, F Takeshita, Y Takahama, H Sakamoto, T Kato, M Terada, T Ochiya 		The FASEB Journal 2006
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Y Minakuchi, F Takeshita, N Kosaka, H Sasaki, Y Yamamoto, M Kouno, K Honma, S Nagahara, K Hanai, A Sano, T Kato, M Terada, T Ochiya 		Nucleic Acids Research 2004
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H Yamamoto, T Ochiya, S Tamamushi, H Toriyama-Baba, Y Takahama, K Hirai, H Sasaki, H Sakamoto, I Saito, T Iwamoto, T Kakizoe, M Terada 		Oncogene 2002
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M Jeffers, WJ LaRochelle, HS Lichenstein 		Expert Opinion on Therapeutic Targets 2002
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