Because tumor necrosis factor-alpha (TNF-alpha) expression is increased in adipose tissue of both rodent models of obesity and obese humans, it has been considered as a candidate gene for obesity. Pima Indians were scored for genotypes at three polymorphic dinucleotide repeat loci (markers) near the gene TNF-alpha at 6p21.3. In a sib-pair linkage analysis, percent body fat, as measured by hydrostatic weighing, was linked (304 sib-pairs, P = 0.002) to the marker closest (10 kb) to TNF-alpha. The same marker was associated (P = 0.01) by analysis of variance with BMI. To search for possible DNA variants in TNF-alpha that contribute to obesity, single stranded conformational polymorphism analysis was performed from 20 obese and 20 lean subjects. Primer pairs were designed for the entire TNF-alpha protein coding region and part of the promoter. Only a single polymorphism located in the promoter region was detected. No association could be demonstrated between alleles at this polymorphism and percent body fat. We conclude that the linkage of TNF-alpha to obesity might be due to a sequence variant undetected in TNF-alpha or due to a variant in some other closely linked gene.
R A Norman, C Bogardus, E Ravussin
Title and authors | Publication | Year |
---|---|---|
LTA, LEP, and TNF-a Gene Polymorphisms are Associated with Susceptibility and Overall Survival of Diffuse Large B-Cell lymphoma in an Arab Population: A Case-Control Study
S Al-Khatib, N Abdo, L Al-Eitan, AH Al-Mistarehi, D Zahran, TZ Kewan |
Asian Pacific Journal of Cancer Prevention | 2020 |
Handbook of Experimental Pharmacology
P Kovacs, T Schöneberg |
Handbook of experimental pharmacology | 2016 |
Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice
JW Ruan, S Statt, CT Huang, YT Tsai, CC Kuo, HL Chan, YC Liao, TH Tan, CY Kao |
Nature Microbiology | 2016 |
Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells
V Upadhyay, YX Fu |
Cytokine & Growth Factor Reviews | 2014 |
Lymphotoxin signalling in immune homeostasis and the control of microorganisms
V Upadhyay, YX Fu |
Nature Reviews Immunology | 2013 |
Linking the microbiota and metabolic disease with lymphotoxin
V Upadhyay, YX Fu |
International Immunology | 2013 |
Emery and Rimoin's Principles and Practice of Medical Genetics
DC Wallace, MT Lott, V Procaccio |
Emery and Rimoin's Principles and Practice of Medical Genetics | 2013 |
Obesity and asthma
P Baruwa, KR Sarmah |
Lung India : official organ of Indian Chest Society | 2013 |
Assessment of 11-β hydroxysteroid dehydrogenase (11-βHSD1) 4478T>G and tumor necrosis factor-α (TNF-α)-308G>A polymorphisms with obesity and insulin resistance in Asian Indians in North India
M Sharma, NK Vikram, A Misra, SP Bhatt, M Tarique, HA Parray, RM Pandey, K Luthra |
Molecular Biology Reports | 2013 |
Lymphotoxin regulates commensal responses to enable diet-induced obesity
V Upadhyay, V Poroyko, T Kim, S Devkota, S Fu, D Liu, AV Tumanov, EP Koroleva, L Deng, C Nagler, EB Chang, H Tang, YX Fu |
Nature Immunology | 2012 |
Overview of Macrophage Migration Inhibitory Factor (MIF) as a Potential Biomarker Relevant to Adiposity
J Nishihira, S Sakaue |
Journal of traditional and complementary medicine | 2012 |
Association between TNF-α promoter G-308A and G-238A polymorphisms and obesity
M Hedayati, K Sharifi, F Rostami, MS Daneshpour, MZ Yeganeh, F Azizi |
Molecular Biology Reports | 2011 |
Genetic Polymorphisms in Adipokine Genes and the Risk of Obesity: A Systematic Review and Meta-Analysis
Z Yu, S Han, X Cao, C Zhu, X Wang, X Guo |
Obesity | 2011 |
Association of TNF-α promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-α and leptin levels in Indian adult women
V Gupta, T Jafar, V Gupta, S Agrawal, N Srivastava, S Kumar, AK Singh, A Gupta, SM Natu, CG Agarwal, GG Agarwal |
Cytokine | 2011 |
Detection of novel SNPs and mapping of the fatness QTL on pig chromosome 7q1.1-1.4 region
WH Huang, ZX Ma, ZY Xu, YZ Xiong, B Zuo |
Genetics and Molecular Research | 2011 |
Sleep Apnea: Pathogenesis, Diagnosis and Treatment
ES Arnardottir, B Sunwoo, AI Pack |
Sleep Apnea: Pathogenesis, Diagnosis and Treatment | 2011 |
Association between anthropometric measures of obesity, metabolic disturbances and polymorphism G-308A of the tumor necrosis factor-alpha gene in children
B Pyrzak, A Wisniewska, K Popko, U Demkow, AM Kucharska |
European Journal of Medical Research | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Genetic locus on rat chromosome 20 regulates diet-induced adipocyte hypertrophy: a microarray gene expression study
C Bourdon, S Hojna, M Jordan, J Bérubé, V Kren, M Pravenec, P Liu, S Arab, Z Pausová |
Physiological genomics | 2009 |
A genome scan for loci affecting adipocyte size and number in abdominal fat in a White Duroc × Erhualian F2 resource population
LT Liu, J Ren, L Li, WB Li, B Yang, WC Zhu, BL Guo, JW Ma, LS Huang |
animal | 2009 |
Obesity and Asthma
DA Beuther |
Clinics in Chest Medicine | 2009 |
Genetic locus on rat chromosome 20 regulates diet-induced adipocyte hypertrophy: a microarray gene expression study
C Bourdon, S Hojna, M Jordan, J Bérubé, V Křen, M Pravenec, P Liu, S Arab, Z Pausová |
Physiological genomics | 2009 |
Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families
LJ Zhao, DH Xiong, F Pan, XG Liu, RR Recker, HW Deng |
Human Genetics | 2008 |
Genetics of variation in adiponectin in pedigreed baboons: evidence for pleiotropic effects on adipocyte volume and serum adiponectin
ME Tejero, VS Voruganti, IP Rodríguez-Sánchez, JM Proffitt, J Blangero, LA Cox, MC Mahaney, J Rogers, JL VandeBerg, SA Cole, AG Comuzzie |
Heredity | 2008 |
Genomewide linkage scan for combined obesity phenotypes using principal component analysis
LN He, YJ Liu, P Xiao, L Zhang, Y Guo, TL Yang, LJ Zhao, B Drees, J Hamilton, HY Deng, RR Recker, HW Deng |
Annals of Human Genetics | 2008 |
Interleukin-1 Beta Gene Polymorphism and Traditional Constitution in Obese Women
JH Lee, YD Kwon, SH Hong, HJ Jeong, HM Kim, JY Um |
International Journal of Neuroscience | 2008 |
Obesity
CY Chen, J Blumberg |
Obesity | 2007 |
Obesity and polymorphisms in genes regulating human adipose tissue
I Dahlman, P Arner |
International Journal of Obesity | 2007 |
The asthma?obesity link in childhood: open questions, complex evidence, a few answers only
PM Matricardi, C Grüber, U Wahn, S Lau |
Clinical & Experimental Allergy | 2007 |
Obesity: Genomics and Postgenomics
A Xu, A Butler, G Barsh |
Obesity: Genomics and Postgenomics | 2007 |
Obesity and asthma
DA Beuther, ST Weiss, ER Sutherland |
American journal of respiratory and critical care medicine | 2006 |
The Human Obesity Gene Map: The 2005 Update
T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel, G Argyropoulos, B Walts, L Pérusse, C Bouchard |
Obesity | 2006 |
A meta-analysis of quantitative trait loci associated with body weight and adiposity in mice
S Wuschke, S Dahm, C Schmidt, HG Joost, H Al-Hasani |
International Journal of Obesity | 2006 |
The Emperor’s New Clothes Are Loose: Lower Body Mass Index, Not Calorie Restriction, Accounts for Improved Diastolic Function
JB Johnson, DR Laub, S John |
Journal of the American College of Cardiology | 2006 |
Adiposity and bone mineral density of Chilean elderly women in relation to toll-like receptor 4 gene polymorphisms
JL Santos, L Lera, F Pérez-Bravo, C Albala |
Annals of Human Biology | 2006 |
The human obesity gene map: the 2004 update
L Pérusse, T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel, G Argyropoulos, B Walts, EE Snyder, C Bouchard |
Obesity research | 2005 |
Nutrition and Diabetes
R Hoeldtke |
Nutrition and Diabetes | 2005 |
Promoter polymorphism in the macrophage migration inhibitory factor gene is associated with obesity
S Sakaue, S Ishimaru, N Hizawa, Y Ohtsuka, I Tsujino, T Honda, J Suzuki, Y Kawakami, J Nishihira, M Nishimura |
International Journal of Obesity | 2005 |
Meta-analysis on the G- 308 A Tumor Necrosis Factor α Gene Variant and Phenotypes Associated with the Metabolic Syndrome
SC Sookoian, C González, CJ Pirola |
Obesity research | 2005 |
Diabetes und Herz
T Meinertz, P Rösen, D Ziegler, A Schömig, D Tschöpe |
2005 | |
The common T60N polymorphism of the lymphotoxin-? gene is associated with type 2 diabetes and other phenotypes of the metabolic syndrome
YH Hamid, SA Urhammer, C Glmer, K Borch-Johnsen, T Jrgensen, T Hansen, O Pedersen |
Diabetologia | 2005 |
The human obesity gene map: the 2003 update
EE Snyder, B Walts, L Pérusse, YC Chagnon, SJ Weisnagel, T Rankinen, C Bouchard |
Obesity research | 2004 |
GENETICS OF ATHEROSCLEROSIS
AJ Lusis, R Mar, P Pajukanta |
Annual Review of Genomics and Human Genetics | 2004 |
Analysis of candidate genes in Polish families with obesity
M Malczewska-Malec, I Wybranska, I Leszczynska-Golabek, L Partyka, J Hartwich, A Jabrocka, B Kiec-Wilk, M Kwasniak, M Motyka, A Dembinska-Kiec |
Clinical Chemistry and Laboratory Medicine | 2004 |
Investigation of Obesity Candidate Genes On Porcine Fat Deposition Quantitative Trait Loci Regions
KS Kim, H Thomsen, J Bastiaansen, NT Nguyen, JC Dekkers, GS Plastow, MF Rothschild |
Obesity research | 2004 |
Pharmacogenetics of antipsychotic-induced weight gain
CU Correll, AK Malhotra |
Psychopharmacology | 2004 |
The human obesity gene map: the 2002 update
YC Chagnon, T Rankinen, EE Snyder, SJ Weisnagel, L Pérusse, C Bouchard |
Obesity research | 2003 |
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
The TNF- α Gene NcoI Polymorphism at Position –308 of the Promoter Influences Insulin Resistance, and Increases Serum Triglycerides after Postprandial Lipaemia in Familiar Obesity
I Wybrańska, M Malczewska-Malec, S Niedbal, JW Naskalski, A Dembińska-Kieć |
Clinical Chemistry and Laboratory Medicine | 2003 |
Gene polymorphisms in tumor necrosis factor locus and waist–hip ratio in obese Koreans
JY Um, JH Park, HM Kim |
Clinica Chimica Acta | 2003 |
Association studies of genetic polymorphisms in central obesity: a critical review
R Rosmond |
International Journal of Obesity | 2003 |
The human obesity gene map: the 2001 update
T Rankinen, L Pérusse, SJ Weisnagel, EE Snyder, YC Chagnon, C Bouchard |
Obesity research | 2002 |
Leptin exists in tubuli seminiferi and in seminal plasma
HJ Glander, A Lammert, U Paasch, A Glasow, J Kratzsch |
Andrologia | 2002 |
Association of the TNF-α−308 G/A Promoter Polymorphism with Insulin Resistance in Obesity
B Dalziel, AK Gosby, RM Richman, JM Bryson, ID Caterson |
Obesity research | 2002 |
Complex interactions in complex traits: obesity and asthma
KG Tantisira, ST Weiss |
Thorax | 2001 |
Manipulating the vascular biology of coronary atherosclerosis in diabetes: New opportunities
JL Orford, S Kinlay, J Fernandes, D Behrendt, P Ganz, AP Selwyn |
Journal of Laboratory and Clinical Medicine | 2001 |
The Human Obesity Gene Map: The 2000 Update
L Pérusse, YC Chagnon, SJ Weisnagel, T Rankinen, E Snyder, J Sands, C Bouchard |
Obesity research | 2001 |
The G-308A variant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution
S Romeo, F Sentinelli, F Capici, M Arca, A Berni, E Vecci, UD Mario, MG Baroni |
BMC Medical Genetics | 2001 |
Tumor necrosis factor-α−308 G/A polymorphism in obese Caucasians
E Brand, U Schorr, I Kunz, E Kertmen, J Ringel, A Distler, AM Sharma |
International Journal of Obesity | 2001 |
Genetic variation in the stress protein hsp70-2 gene is highly associated with obesity
L Chouchane, J Danguir, C Beji, K Bouassida, L Camoin, H Sfar, S Gabbouj, AD Strosberg |
International Journal of Obesity | 2001 |
G-308A Polymorphism of the Tumor Necrosis Factorα Gene Promoter and Salivary Cortisol Secretion1
R Rosmond, M Chagnon, C Bouchard, P Björntorp |
The Journal of clinical endocrinology and metabolism | 2001 |
Genetics of the metabolic syndrome
L Groop |
British Journal of Nutrition | 2000 |
Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
DE Moller |
Trends in Endocrinology & Metabolism | 2000 |
Obesity — a genetic disease of adipose tissue?
P Arner |
British Journal of Nutrition | 2000 |
Insulin attenuates the stimulatory effects of tumor necrosis factor alpha on 11beta-hydroxysteroid dehydrogenase 1 in human adipose stromal cells
K Handoko, K Yang, B Strutt, W Khalil, D Killinger |
The Journal of Steroid Biochemistry and Molecular Biology | 2000 |
El aumento de la actividad proinflamatoria es consustancial a la resistencia a la insulina
JM Fernández-Real, W Ricart |
Medicina Clínica | 2000 |
The Human Obesity Gene Map: The 1999 Update
YC Chagnon, L Pérusse, SJ Weisnagel, T Rankinen, C Bouchard |
Obesity research | 2000 |
PLASMA TUMOR NECROSIS FACTOR α LEVELS AND INSULIN SENSITIVITY IN HYPERTENSIVE SUBJECTS
WH Sheu, WJ Lee, RL Chang, YT Chen |
Clinical and Experimental Hypertension | 2000 |
Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A
CJ der Kallen, RM Cantor, MM Greevenbroek, JM Geurts, FG Bouwman, BE Aouizerat, H Allayee, WA Buurman, AJ Lusis, JI Rotter, TW Bruin |
International Journal of Obesity | 2000 |
An autosomal genomic scan for loci linked to plasma leptin concentration in Pima Indians
K Walder, RL Hanson, S Kobes, WC Knowler, E Ravussin |
International Journal of Obesity | 2000 |
Role of Tumor Necrosis Factor-α Gene Locus in Obesity and Obesity-Associated Hypertension in French Canadians
Z Pausova, B Deslauriers, D Gaudet, J Tremblay, TA Kotchen, P Larochelle, AW Cowley, P Hamet |
Hypertension | 2000 |
Obesity: Pathology and Therapy
DH Lockwood, TC Heffner |
2000 | |
Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) – genetic predisposition and metabolic abnormalities
HS Jun, HY Bae, BR Lee, KS Koh, YS Kim, KW Lee, H Kim, JW Yoon |
Advanced Drug Delivery Reviews | 1999 |
The Human Obesity Gene Map: The 1998 Update
L Pérusse, YC Chagnon, J Weisnagel, C Bouchard |
Obesity research | 1999 |
Tumour necrosis factor, a key role in obesity?
M Bulló-Bonet, P García-Lorda, FJ López-Soriano, JM Argilés, J Salas-Salvadó |
FEBS Letters | 1999 |
The Insulin-Related Ovarian Regulatory System in Health and Disease
L Poretsky, NA Cataldo, Z Rosenwaks, LC Giudice |
Endocrine reviews | 1999 |
Circulating Tumor Necrosis Factor-α Concentrations in a Native Canadian Population with High Rates of Type 2 Diabetes Mellitus1
B Zinman, AJ Hanley, SB Harris, J Kwan, IG Fantus |
The Journal of clinical endocrinology and metabolism | 1999 |
Hypertension
P Hamet, Z Pausova, V Adarichev, K Adaricheva, J Tremblay |
Journal of Hypertension | 1998 |
Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity
Herrmann, Ricard, Nicaud, Mallet, Arveiler, Evans, Ruidavets, Luc, Bara, Parra, Poirier, Cambien |
European Journal of Clinical Investigation | 1998 |
COSEGREGATION OF THETnf��LOCUS WITH CARDIOVASCULAR PHENOTYPES IN THE F2GENERATION OF A NEW ZEALAND GENETICALLY HYPERTENSIVE AND BROWN NORWAY CROSS
EL Harris, MR Grigor, CM Thompson |
Clinical and Experimental Pharmacology and Physiology | 1998 |
Multiple Phenotype Modeling in Gene-Mapping Studies of Quantitative Traits: Power Advantages
DB Allison, B Thiel, PS Jean, RC Elston, MC Infante, NJ Schork |
The American Journal of Human Genetics | 1998 |
The Human Obesity Gene Map: The 1997 Update
YC Chagnon, L Pérusse, C Bouchard |
Obesity research | 1998 |
Hypothesis: muscle insulin resistance is the ("not-so") thrifty genotype
GF Cahill, OE Owen |
Diabetologia | 1998 |
Hypothesis: muscle insulin resistance is the ("not-so") thrifty genotype
GF Cahill, OE Owen |
Diabetologia | 1998 |
Genetics of human body size and shape: pleiotropic and independent genetic determinants of adiposity
G Livshits, K Yakovenko, E Ginsburg, E Kobyliansky |
Annals of Human Biology | 1998 |
Advancing age and insulin resistance: role of plasma tumor necrosis factor-α
G Paolisso, MR Rizzo, G Mazziotti, MR Tagliamonte, A Gambardella, M Rotondi, C Carella, D Giugliano, M Varricchio, F DOnofrio |
American journal of physiology. Endocrinology and metabolism | 1998 |
A genome-wide scan for human obesity genes reveals a major susceptibilitylocus on chromosome 10
J Hager, C Dina, S Francke, S Dubois, M Houari, V Vatin, E Vaillant, N Lorentz, A Basdevant, K Clement, B Guy-Grand, P Froguel |
Nature Genetics | 1998 |
Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF-α-Mediated Insulin Resistance in Genetic Obesity**This work is supported in part by a grant from the NIH (DK-52539)
KT Uysal, SM Wiesbrock, GS Hotamisligil |
Endocrinology | 1998 |
Autosomal genomic scan for loci linked to obesity and energy metabolism in Pima Indians.
Norman RA, Tataranni PA, Pratley R, Thompson DB, Hanson RL, Prochazka M, Baier L, Ehm MG, Sakul H, Foroud T, Garvey WT, Burns D, Knowler WC, Bennett PH, Bogardus C, Ravussin E |
The American Journal of Human Genetics | 1998 |
Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q
AV Lembertas, L Pérusse, YC Chagnon, JS Fisler, CH Warden, DA Purcell-Huynh, FT Dionne, J Gagnon, A Nadeau, AJ Lusis, C Bouchard |
Journal of Clinical Investigation | 1997 |
Non-insulin-dependent Diabetes Mellitus - A Collision between Thrifty Genes and an Affluent Society
LC Groop, T Tuomi |
Annals of Medicine | 1997 |
Recessive Inheritance of Obesity in Familial Non—Insulin-Dependent Diabetes Mellitus, and Lack of Linkage to Nine Candidate Genes
SJ Hasstedt, M Hoffman, MF Leppert, SC Elbein |
The American Journal of Human Genetics | 1997 |
Human Variation in Body Mass: Evidence for a Role of the Genes
C Bouchard |
Nutrition Reviews | 1997 |
Obesity QTLs on Mouse Chromosomes 2 and 17
BA Taylor, SJ Phillips |
Genomics | 1997 |
Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians
H Sakul, R Pratley, L Cardon, E Ravussin, D Mott, C Bogardus |
The American Journal of Human Genetics | 1997 |
The Human Obesity Gene Map: The 1996 Update
L Pérusse, YC Chagnon, FT Dionne, C Bouchard |
Obesity research | 1997 |
Human obesity genes
SB Roberts |
Nutrition | 1997 |
The Genetics of Human Noninsulin-Dependent (Type 2) Diabetes Mellitus
SC Elbein |
The Journal of nutrition | 1997 |
Genetics of Human Obesity: Recent Results from Linkage Studies
C Bouchard |
The Journal of nutrition | 1997 |
Metabolic changes in elderly cancer patients after glucose ingestion: The role of tumor necrosis factor-?
A Gambardella, R Tortoriello, MR Tagliamonte, G Paolisso, M Varricchio |
Cancer | 1997 |
THE ENDOCRINOLOGY OF OBESITY
SR Smith |
Endocrinology & Metabolism Clinics of North America | 1996 |
The New Obesity Genes
SB Roberts, AS Greenberg |
Nutrition Reviews | 1996 |
GENETICS OF OBESITY IN HUMANS AND ANIMAL MODELS
DB West |
Endocrinology & Metabolism Clinics of North America | 1996 |
A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
CL Hanis, E Boerwinkle, R Chakraborty, DL Ellsworth, P Concannon, B Stirling, VA Morrison, B Wapelhorst, RS Spielman, KJ Gogolin-Ewens, JM Shepard, SR Williams, N Risch, D Hinds, N Iwasaki, M Ogata, Y Omori, C Petzold, H Rietzch, HE Schröder, J Schulze, NJ Cox, S Menzel, VV Boriraj, X Chen, LR Lim, T Lindner, LE Mereu, YQ Wang, K Xiang, K Yamagata, Y Yang, GI Bell |
Nature Genetics | 1996 |
Current Status of the Human Obesity Gene Map
C Bouchard, L Pérusse |
Obesity research | 1996 |
Metabolic differences and the development of obesity
E Ravussin |
Metabolism | 1995 |