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Citations to this article

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
J C Plumier, … , G Kollias, G N Pagoulatos
J C Plumier, … , G Kollias, G N Pagoulatos
Published April 1, 1995
Citation Information: J Clin Invest. 1995;95(4):1854-1860. https://doi.org/10.1172/JCI117865.
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Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.

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Abstract

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock proteins, the amount of the inducible heat shock protein 70 (HSP70) and the level of myocardial protection. The inducible HSP70 has also been shown to be protective in transfected myogenic cells. Here we examined the role of human inducible HSP70 in transgenic mouse hearts. Overexpression of the human HSP70 does not appear to affect normal protein synthesis or the stress response in transgenic mice compared with nontransgenic mice. After 30 min of ischemia, upon reperfusion, transgenic hearts versus nontransgenic hearts showed significantly improved recovery of contractile force (0.35 +/- 0.08 versus 0.16 +/- 0.05 g, respectively, P < 0.05), rate of contraction, and rate of relaxation. Creatine kinase, an indicator of cellular injury, was released at a high level (67.7 +/- 23.0 U/ml) upon reperfusion from nontransgenic hearts, but not transgenic hearts (1.6 +/- 0.8 U/ml). We conclude that high level constitutive expression of the human inducible HSP70 plays a direct role in the protection of the myocardium from ischemia and reperfusion injury.

Authors

J C Plumier, B M Ross, R W Currie, C E Angelidis, H Kazlaris, G Kollias, G N Pagoulatos

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Influence of PKC-α overexpression on HSP70 and cardioprotection
SD Coaxum, TM Griffin, JL Martin, R Mestril
American journal of physiology. Heart and circulatory physiology 2007
EFFECTS OF THERMAL PRECONDITIONING ON THE ISCHEMIA-REPERFUSION-INDUCED ACUTE LUNG INJURY IN MINIPIGS
SP Luh, PH Kuo, TF Kuo, TP Tsai, TC Tsao, JY Chen, CH Tsai, PC Yang
Shock 2007
Heat shock response and acute lung injury
DS Wheeler, HR Wong
Free radical biology & medicine 2006
Organ preconditioning: the past, current status, and related lung studies
S Luh, P Yang
Journal of Zhejiang University SCIENCE B 2006
Exercise is the primary factor associated with Hsp70 induction in muscle of treadmill running rats
EG Noble, R Ho, T Dzialoszynski
Acta Physiologica 2006
DY-9760e, a Novel Calmodulin Inhibitor, Exhibits Cardioprotective Effects in the Ischemic Heart
K Fukunaga, F Han, N Shioda, S Moriguchi, J Kasahara, Y Shirasaki
Cardiovascular Drug Reviews 2006
Hyperbaric oxygen: a new drug in myocardial revascularization and protection?
JZ Yogaratnam, G Laden, LA Madden, AM Seymour, L Guvendik, M Cowen, J Greenman, A Cale, S Griffin
Cardiovascular Revascularization Medicine 2006
Preconditioning Versus Postconditioning: Mechanisms and Therapeutic Potentials
PR Crisostomo, GM Wairiuko, M Wang, BM Tsai, ED Morrell, DR Meldrum
Journal of the American College of Surgeons 2006
Simvastatin induces heat shock factor 1 in vascular endothelial cells
T Uchiyama, H Atsuta, T Utsugi, Y Ohyama, T Nakamura, A Nakai, M Nakata, I Maruyama, H Tomura, F Okajima, S Tomono, S Kawazu, R Nagai, M Kurarbayashi
Atherosclerosis 2006
Benzo(a)pyrene inhibits expression of inducible heat shock protein 70 in vascular endothelial cells
Z Gong, J Yang, M Yang, F Wang, Q Wei, RM Tanguay, T Wu
Toxicology Letters 2006
L'agrégation toxique des protéines : une forme de « délinquance moléculaire » activement combattue dans la cellule par les chaperones moléculaires et les protéases
MP Hinault, P Goloubinoff
Annales de Cardiologie et d Angéiologie 2006
Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis
KD Singleton, PE Wischmeyer
American journal of physiology. Lung cellular and molecular physiology 2006
Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells
HT Lee, M Kim, M Jan, CW Emala
American journal of physiology. Renal physiology 2006
Overexpressed heat shock protein 70 protects cells against DNA damage caused by ultraviolet C in a dose-dependent manner
P Niu, L Liu, Z Gong, H Tan, F Wang, J Yuan, Y Feng, Q Wei, RM Tanguay, T Wu
Cell Stress and Chaperones 2006
Whole-body heat shock protects the ischemic rat heart by stimulating mitochondria respiration
TL Broderick
Canadian Journal of Physiology and Pharmacology 2006
Castration inhibits exercise-induced accumulation of Hsp70 in male rodent hearts
KJ Milne, DB Thorp, CW Melling, EG Noble
American journal of physiology. Heart and circulatory physiology 2006
Insulin induces myocardial protection and Hsp70 localization to plasma membranes in rat hearts
G Li, IS Ali, RW Currie
American journal of physiology. Heart and circulatory physiology 2006
Heat shock proteins, end effectors of myocardium ischemic preconditioning?
MC Guisasola, M del Mar Desco, FS Gonzalez, F Asensio, E Dulin, A Suarez, PG Barreno
Cell Stress and Chaperones 2006
A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro
G Hu, J Tang, B Zhang, Y Lin, J Hanai, J Galloway, V Bedell, N Bahary, Z Han, R Ramchandran, B Thisse, C Thisse, LI Zon, VP Sukhatme
Journal of cell science 2006
HSP60, Bax, Apoptosis and the Heart
S Gupta, AA Knowlton
Journal of Cellular and Molecular Medicine 2005
Preconditioning with 1,25-Dihydroxyvitamin D<sub>3</sub> Protects against Subsequent Ischemia-Reperfusion Injury in the Rat Kidney
YO Kim, C Li, BK Sun, JS Kim, SW Lim, BS Choi, YS Kim, J Kim, BK Bang, CW Yang
Nephron Experimental Nephrology 2005
Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70
S Suzuki, S Maruyama, W Sato, Y Morita, F Sato, Y Miki, S Kato, M Katsuno, G Sobue, Y Yuzawa, S Matsuo
Kidney International 2005
An anti-ulcer drug, geranylgeranylacetone, suppresses inducible nitric oxide synthase in cultured vascular smooth muscle cells
K Yamamoto, M Sarukawa, T Ito, H Aoki, M Ichida, K Shimada
Journal of Hypertension 2005
Cytoprotective Effect of 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole Dihydrochloride 3.5 Hydrate (DY-9760e) Against Ischemia/Reperfusion-Induced Injury in Rat Heart Involves Inhibition of Fodrin Breakdown and Protein Tyrosine Nitration
M Hashimoto, Y Takada, Y Takeuchi, J Kasahara, H Hisa, Y Shirasaki, K Fukunaga
Journal of Pharmacological Sciences 2005
Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: Implication for sensitivity to stress and inflammation
NA Crivello, IH Rosenberg, GE Dallal, D Bielinski, JA Joseph
Neurochemistry International 2005
Association of High Intracellular, But Not Serum, Heat Shock Protein 70 With Postoperative Atrial Fibrillation
K Mandal, E Torsney, J Poloniecki, AJ Camm, Q Xu, M Jahangiri
The Annals of Thoracic Surgery 2005
Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population
M Yang, T Wu, L Cheng, F Wang, Q Wei, RM Tanguay
Respiratory Research 2005
Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population
F Zhou, F Wang, F Li, J Yuan, H Zeng, Q Wei, RM Tanguay, T Wu
Cell stress & chaperones 2005
Role of tumour necrosis factor-alpha and other cytokines in ischemia-reperfusion-induced injury in the heart
HK Saini, YJ Xu, M Zhang, PP Liu, LA Kirshenbaum, NS Dhalla
Experimental and clinical cardiology 2005
Heat shock protein: Tracing the enemy in septic shock*
WB de Carvalho, MC Fonseca
Pediatric Critical Care Medicine 2005
THERAPEUTIC TREATMENT WITH L-ARGININE RESCUES MICE FROM HEAT STROKE-INDUCED DEATH: PHYSIOLOGICAL AND MOLECULAR MECHANISMS
S Chatterjee, S Premachandran, D Sharma, RS Bagewadikar, TB Poduval
Shock 2005
Preservation of heat stress induced myocardial hsp 72 in aged animals following caloric restriction
B Frier, M Locke
Experimental Gerontology 2005
Neuroprotective effects of HSP70 overexpression after cerebral ischaemia—An MRI study
L der Weerd, MF Lythgoe, RA Badin, LM Valentim, MT Akbar, JS de Belleroche, DS Latchman, DG Gadian
Experimental Neurology 2005
NeuroImmune Biology
R Solana, G Pawelec
NeuroImmune Biology 2005
Effect of mutation of amino acids 246–251 (KRKHKK) in HSP72 on protein synthesis and recovery from hypoxic injury
MR Voss, S Gupta, JP Stice, G Baumgarten, L Lu, JM Tristan, AA Knowlton
American journal of physiology. Heart and circulatory physiology 2005
Cytokines and cardiovascular disease
VC Mehra, VS Ramgolam, JR Bender
Journal of leukocyte biology 2005
Expression of constitutively stable hybrid hypoxia-inducible factor-1α protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury
T Date, S Mochizuki, AJ Belanger, M Yamakawa, Z Luo, KA Vincent, SH Cheng, RJ Gregory, C Jiang
American journal of physiology. Cell physiology 2005
Principles of Molecular Cardiology
MS Runge, C Patterson
2005
Sequestration of TRAF2 into Stress Granules Interrupts Tumor Necrosis Factor Signaling under Stress Conditions
WJ Kim, SH Back, V Kim, I Ryu, SK Jang
Molecular and cellular biology 2005
Protective role of heat stress in burn trauma*
DJ White, D Carlson, GA Ordway, JW Horton
Critical Care Medicine 2004
Induction of heat shock protein 70 in failing heart
K TANONAKA, W TOGA, S TAKEO
Folia Pharmacologica Japonica 2004
Cell Death Pathways in Pancreatitis and Pancreatic Cancer
AS Gukovskaya, SJ Pandol
Pancreatology 2004
The Role of Innate Immune Responses in the Heart in Health and Disease
P Knuefermann, J Vallejo, DL Mann
Trends in Cardiovascular Medicine 2004
Heat shock protein 27 protects the heart against myocardial infarction
CA Efthymiou, MM Mocanu, J Belleroche, DJ Wells, DS Latchmann, DM Yellon
Basic Research in Cardiology 2004
HSF1 blockade-induced tumor thermotolerance abolishment is mediated by JNK-dependent caspase-3 activation
JH Wang, MZ Yao, ZL Zhang, YH Zhang, YG Wang, XY Liu
Biochemical and Biophysical Research Communications 2004
Keeping up the defenses
RD Griffiths, A McArdle
Nutrition 2004
The Upregulation of Cognate and Inducible Heat Shock Proteins in the Anoxic Turtle Brain
HM Prentice, SL Milton, D Scheurle, PL Lutz
Journal of Cerebral Blood Flow & Metabolism 2004
Preconditioning: Evolution of Basic Mechanisms to Potential Therapeutic Strategies
BM Tsai, M Wang, KL March, MW Turrentine, JW Brown, DR Meldrum
Shock 2004
Cytochrome c oxidase as the target of the heat shock protective effect in septic liver
HW Chen, HT Kuo, TS Lu, SJ Wang, RC Yang
International Journal of Experimental Pathology 2004
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction
X Jin, C Xiao, RM Tanguay, L Yang, F Wang, M Chen, X Fu, R Wang, J Deng, Z Deng, Y Zheng, Q Wei, T Wu
The American Journal of Medicine 2004
Expression of the 60 kDa and 71 kDa heat shock proteins and presence of antibodies against the 71 kDa heat shock protein in pediatric patients with immune thrombocytopenic purpura
C Xiao, S Chen, M Yuan, F Ding, D Yang, R Wang, J Li, RM Tanguay, T Wu
BMC Hematology 2004
Protein kinase C-dependent activation of P44/42 mitogen-activated protein kinase and heat shock protein 70 in signal transduction during hepatocyte ischemic preconditioning
Yi Gao, Yu-Qiang Shan, Ming-Xin Pan, Yu Wang, Li-Jun Tang, Hao Li, Zhi Zhang
World journal of gastroenterology : WJG 2004
Heat shock treatment suppresses angiotensin II-induced activation of NF-κB pathway and heart inflammation: a role for IKK depletion by heat shock?
Y Chen, AP Arrigo, RW Currie
American journal of physiology. Heart and circulatory physiology 2004
Rapid, transient, and dose-dependent expression of Hsp70 messenger RNA in the rat brain after morphine treatment
S Ammon-Treiber, G Grecksch, R Stumm, U Riechert, H Tischmeyer, A Reichenauer, V Höllt
Cell Stress and Chaperones 2004
Heat shock treatment protects against angiotensin II–induced hypertension and inflammation in aorta
Y Chen, BM Ross, RW Currie
Cell Stress and Chaperones 2004
Radicicol activates heat shock protein expression and cardioprotection in neonatal rat cardiomyocytes
TM Griffin, TV Valdez, R Mestril
American journal of physiology. Heart and circulatory physiology 2004
Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population
X Jin, R Wang, C Xiao, L Cheng, F Wang, L Yang, T Feng, M Chen, S Chen, X Fu, J Deng, R Wang, F Tang, Q Wei, RM Tanguay, T Wu
Cell Stress and Chaperones 2004
Heat shock proteins can protect aged human and rodent cells from different stressful stimuli
S Alsbury, K Papageorgiou, DS Latchman
Mechanisms of Ageing and Development 2004
Enforced expression of oxygen-regulated protein, ORP150, induces vacuolar degeneration in mouse myocardium
Tomohiro Kobayashi, Yasuhiko Ohta
Transgenic Research 2003
Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids
H Irie, IB Krukenkamp, JF Brinkmann, GR Gaudette, AE Saltman, W Jou, JF Glatz, NA Abumrad, A Ibrahimi
Proceedings of the National Academy of Sciences 2003
STRESS-ACTIVATEDCYTOKINES ANDTHEHEART: From Adaptation to Maladaptation1
DL Mann
Annual Review of Physiology 2003
Necrosis: a specific form of programmed cell death?
SY Proskuryakov, AG Konoplyannikov, VL Gabai
Experimental Cell Research 2003
Herbimycin A attenuates apoptosis during heat stress in rats
SB Sachidhanandam, J Lu, KS Low, SM Moochhala
European Journal of Pharmacology 2003
Preconditioned somatothermal stimulation on median nerve territory increases myocardial heat shock protein 70 and protects rat hearts against ischemia-reperfusion injury
JH Chiu, MT Tsou, HH Tung, CH Tai, SK Tsai, CL Chih, JG Lin, CW Wu
The Journal of Thoracic and Cardiovascular Surgery 2003
HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts
CR Hampton, A Shimamoto, CL Rothnie, J Griscavage-Ennis, A Chong, DJ Dix, ED Verrier, TH Pohlman
American journal of physiology. Heart and circulatory physiology 2003
Gender differences in the expression of heat shock proteins: the effect of estrogen
MR Voss, JN Stallone, M Li, RN Cornelussen, P Knuefermann, AA Knowlton
American journal of physiology. Heart and circulatory physiology 2003
Regulation of Necrosis of H9c2 Myogenic Cells upon Transient Energy Deprivation: RAPID DEENERGIZATION OF MITOCHONDRIA PRECEDES NECROSIS AND IS CONTROLLED BY REACTIVE OXYGEN SPECIES, STRESS KINASE JNK, HSP72, AND ARC
JA Yaglom, D Ekhterae, VL Gabai, MY Sherman
The Journal of biological chemistry 2003
Age and attenuation of exercise-induced myocardial HSP72 accumulation
HA Demirel, KL Hamilton, RA Shanely, N Tümer, MJ Koroly, SK Powers
American journal of physiology. Heart and circulatory physiology 2003
Basal and inducible levels of Hsp70 in patients with acute heat illness induced during training
C Xiao, T Wu, A Ren, Q Pan, S Chen, F Wu, X Li, R Wang, LE Hightower, RM Tanguay
Cell Stress and Chaperones 2003
Overexpression of heat shock proteins differentially modulates protein kinase C expression in rat neonatal cardiomyocytes
SD Coaxum, JL Martin, R Mestril
Cell Stress and Chaperones 2003
Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein
Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Chen Sang, Gerassimos Pagoulatos, Charalampos Angelidis, Moriaki Kusakabe, Atsushi Yoshiki, Yasushi Kobayashi, Manabu Doyu, Gen Sobue
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Preconditioning with erythropoietin protects against subsequent ischemia‐reperfusion injury in rat kidney
CW Yang, C Li, JY Jung, SJ Shin, BS Choi, SW Lim, BK Sun, YS Kim, J Kim, YS Chang, BK Bang
The FASEB Journal 2003
The heat shock-induced cell cycle arrest is attenuated by weak electromagnetic fields: Stress protection by EMF
SV Tokalov, HO Gutzeit
Cell Proliferation 2003
Heat Shock Protein 70 Chaperone Overexpression Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model by Reducing Nuclear-Localized Mutant Androgen Receptor Protein
Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatos G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G
Journal of Neuroscience 2003
The atrial natriuretic peptide and cGMP: novel activators of the heat shock response in rat livers
AK Kiemer, AL Gerbes, M Bilzer, AM Vollmar
Hepatology 2002
Wiley Encyclopedia of Molecular Medicine
WT Morgan
Wiley Encyclopedia of Molecular Medicine 2002
Encyclopedia of Molecular Biology
B Mannervik
Encyclopedia of Molecular Biology 2002
The Yin/Yang of Innate Stress Responses in the Heart
D Mann
Cold Spring Harbor Symposia on Quantitative Biology 2002
The Interaction Between HSP70 and TNF-?? Expression: A Novel Mechanism for Protection of the Myocardium Against Post-Injury Depression
X Meng, AH Harken
Shock 2002
Understanding myocardial ischemic preconditioning, and the implications for a role of adenosine catabolism
M Kavianipour
Upsala Journal of Medical Sciences 2002
Exercise and cardioprotection
SK Powers, SL Lennon, J Quindry, JL Mehta
Current Opinion in Cardiology 2002
Heat stress increases endothelium-dependent relaxations and prevents reperfusion-induced endothelial dysfunction
V Richard, K Laude, C Artigues, N Kaeffer, JP Henry, C Thuillez
Clinical and Experimental Pharmacology and Physiology 2002
Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: Influence of Bcl-2
S Kelly, ZJ Zhang, H Zhao, L Xu, RG Giffard, RM Sapolsky, MA Yenari, GK Steinberg
Annals of Neurology 2002
Heat shock factor 1 and heat shock proteins: Critical partners in protection against acute cell injury
ES Christians, LJ Yan, IJ Benjamin
Critical Care Medicine 2002
Interactions between the heat shock response and the nuclear factor-κB signaling pathway
V Malhotra, HR Wong
Critical Care Medicine 2002
HSP70 Expression in Skeletal Muscle of Patients with Peripheral Arterial Occlusive Disease
Y Liu, M Lehmann, C Baur, M Storck, L Sunder-Plassmann, JM Steinacker
European Journal of Vascular and Endovascular Surgery 2002
Blocking HSF1 by Dominant-Negative Mutant to Sensitize Tumor Cells to Hyperthermia
JH Wang, MZ Yao, JF Gu, LY Sun, YF Shen, XY Liu
Biochemical and Biophysical Research Communications 2002
Glutamine and heat shock protein expression
PE Wischmeyer
Nutrition 2002
Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats
NL Lubbers, JS Polakowski, CD Wegner, SE Burke, GJ Diaz, KM Daniell, BF Cox
European Journal of Pharmacology 2002
Mydj2 as a potent partner of hsc70 in mammalian cells
P Bozidis, I Lazaridis, GN Pagoulatos, CE Angelidis
European Journal of Biochemistry 2002
Advances in Cell Aging and Gerontology
T Fülöp, K Hirokawa, G Dupuis, A Larbi, G Pawelec
Advances in Cell Aging and Gerontology 2002
Heme oxygenase-1 pathway is involved in delayed protection induced by heat stress against cardiac ischemia–reperfusion injury
R Lu, J Peng, L Xiao, HW Deng, YJ Li
International Journal of Cardiology 2002
Changes in heat shock protein 70 localization and its content in rabbit aorta at various stages of experimental atherosclerosis
B Geetanjali, S Uma, MP Bansal
Cardiovascular Pathology 2002
Acute Lung Injury
GD Leikauf, SA McDowell, SC Wesselkamper, WD Hardie, JE Leikauf, TR Korfhagen, DR Prows
Chest 2002
Exercise-induced elevation of HSP70 is intensity dependent
KJ Milne, EG Noble
Journal of applied physiology 2002
Association of HSP70 and genotoxic damage in lymphocytes of workers exposed to coke-oven emission
C Xiao, S Chen, J Li, T Hai, Q Lu, E Sun, R Wang, RM Tanguay, T Wu
Cell Stress and Chaperones 2002
Characterization and functional analysis of a heart-enriched DnaJ/Hsp40 homolog dj4/DjA4
KhalequeAbdul, K Terada, T Gotoh, RahmanHafizur, M Mori
Cell Stress and Chaperones 2002
Drug Discovery and Evaluation
HG Vogel, WH Vogel, BA Schölkens, J Sandow, G Müller, WF Vogel
2002
Exercise Improves Postischemic Cardiac Function in Males but Not Females: Consequences of a Novel Sex-Specific Heat Shock Protein 70 Response
Z Paroo, JV Haist, M Karmazyn, EG Noble
Circulation research 2002
The Sepsis Text
JL Vincent, J Carlet, SM Opal
2002
Molecular and Cellular Biology of Neuroprotection in the CNS
C Alzheimer
2002
Small Stress Proteins
AP Arrigo, WE Müller
2002
Effect of long-term treatment with trandolapril on Hsp72 and Hsp73 induction of the failing heart following myocardial infarction
K Tanonaka, W Toga, H Yoshida, K Furuhama, S Takeo
British Journal of Pharmacology 2001
Role of nitric oxide synthases in the infarct size-reducing effect conferred by heat stress in isolated rat hearts
C Arnaud, A Laubriet, M Joyeux, D Godin-Ribuot, L Rochette, P Demenge, C Ribuot
British Journal of Pharmacology 2001
Differential Neuroprotection from Human Heat Shock Protein 70 Overexpression in in Vitro and in Vivo Models of Ischemia and Ischemia-like Conditions
JE Lee, MA Yenari, GH Sun, L Xu, MR Emond, D Cheng, GK Steinberg, RG Giffard
Experimental Neurology 2001
Induction of stress response proteins and experimental renal ischemia/reperfusion
KJ Kelly, NR Baird, AL Greene
Kidney International 2001
Functional properties and responses to ischaemia-reperfusion in Langendorff perfused mouse heart
JP Headrick, J Peart, B Hack, A Flood, GP Matherne
Experimental Physiology 2001
Multilateral in Vivo and in Vitro Protective Effects of the Novel Heat Shock Protein Coinducer, Bimoclomol: Results of Preclinical Studies
PP Nánási, A Jednákovits
Cardiovascular Drug Reviews 2001
Overexpression of HSP72 After Induction of Experimental Stroke Protects Neurons From Ischemic Damage
B Hoehn, TM Ringer, L Xu, RG Giffard, RM Sapolsky, GK Steinberg, MA Yenari
Journal of Cerebral Blood Flow & Metabolism 2001
Hyperthermic Pretreatment Decreases Microvascular Protein Leakage and Attenuates Hypotension in Anaphylactic Shock in Rats
SC Chen, TS Lu, HL Lee, SI Lue, RC Yang
Microvascular Research 2001
Preconditioning Somatothermal Stimulation on Right Seventh Intercostal Nerve Territory Increases Hepatic Heat Shock Protein 70 and Protects the Liver from Ischemia–Reperfusion Injury in Rats
YH Lin, JH Chiu, HH Tung, MT Tsou, WY Lui, CW Wu
Journal of Surgical Research 2001
Whole Body Hyperthermia Accelerates Atherogenesis in Low-Density Lipoprotein Receptor Deficient Mice
A Afek, G Keren, D Harats, J George
Experimental and Molecular Pathology 2001
Continuous and pulsed ultrasound do not increase heat shock protein 72 content
M Locke, E Nussbaum
Ultrasound in Medicine & Biology 2001
Cold Stress Does Not Induce Stress Proteins SP 25 and SP 72 in Rat Skeletal Muscle
M Locke, C Celotti
Cryobiology 2001
APOPTOSIS IN MYOCARDIAL ISCHEMIA, INFARCTION, AND ALTERED MYOCARDIAL STATES
RR Baliga
Cardiology Clinics 2001
Gender, Physical Activity, and Aging
D Paterson, L Stathokostas
Gender, Physical Activity, and Aging 2001
Stress Protein Involvement in Cardioprotection Induced by Hypothermia
R Mestril
Journal of Molecular and Cellular Cardiology 2001
Mechanisms of cell death in acute myocardial infarction: pathophysiological implications for treatment
C de Zwaan, M J A P Daemen, W Th Hermens
Netherlands Heart Journal 2001
Heat Shock Proteins and Cardiovascular Pathophysiology
LH Snoeckx, RN Cornelussen, FA van Nieuwenhoven, RS Reneman, GJ van der Vusse
Physiological reviews 2001
Effects of tobacco smoke and benzo[ a ]pyrene on human endothelial cell and monocyte stress responses
M Vayssier-Taussat, T Camilli, Y Aron, C Meplan, P Hainaut, BS Polla, B Weksler
American journal of physiology. Heart and circulatory physiology 2001
Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice
Z Chen, CC Chua, YS Ho, RC Hamdy, BH Chua
American journal of physiology. Heart and circulatory physiology 2001
Strategies of Hypoxia and Anoxia Tolerance in Cardiomyocytes from the Overwintering Common Frog, Rana temporaria
S Currie, RG Boutilier
Physiological and Biochemical Zoology 2001
Contribution of heat shock proteins to cell protection from complement-mediated lysis
Z Fishelson, I Hochman, LE Greene, E Eisenberg
International Immunology 2001
Protective effect of heat shock protein 72 on contractile function of perfused failing heart
K Tanonaka, KI Furuhama, H Yoshida, K Kakuta, Y Miyamoto, W Toga, S Takeo
American journal of physiology. Heart and circulatory physiology 2001
Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins
KL Hamilton, SK Powers, T Sugiura, S Kim, S Lennon, N Tumer, JL Mehta
American journal of physiology. Heart and circulatory physiology 2001
Ischemic-reperfused isolated working mouse hearts: membrane damage and type IIA phospholipase A 2
LJ de Windt, J Willems, TH Roemen, WA Coumans, RS Reneman, GJ van der Vusse, MV Bilsen
American journal of physiology. Heart and circulatory physiology 2001
Heat pretreatment differentially affects cardiac fatty acid accumulation during ischemia and postischemic reperfusion
RN Cornelussen, GJ van der Vusse, TH Roemen, LH Snoeckx
American journal of physiology. Heart and circulatory physiology 2001
Role of priming stresses and Hsp70 in protection from ischemia-reperfusion injury in cardiac and skeletal muscle
DA Lepore, KR Knight, RL Anderson, WA Morrison
Cell Stress and Chaperones 2001
Association of plasma antibodies against the inducible Hsp70 with hypertension and harsh working conditions
T Wu, J Ma, S Chen, Y Sun, C Xiao, Y Gao, R Wang, J Poudrier, M Dargis, RW Currie, RM Tanguay
Cell Stress and Chaperones 2001
Presence of antibody against the inducible Hsp71 in patients with acute heat-induced illness
T Wu, S Chen, C Xiao, C Wang, Q Pan, Z Wang, M Xie, Z Mao, Y Wu, RM Tanguay
Cell Stress and Chaperones 2001
Roles of the heat shock transcription factors in regulation of the heat shock response and beyond
L Pirkkala, PÄ Nykänen, L Sistonen
The FASEB Journal 2001
Role of inducible heat shock protein 70 in radiation-induced cell death
SJ Lee, SA Choi, KH Lee, HY Chung, TH Kim, CK Cho, YS Lee
Cell Stress and Chaperones 2001
PHARMACOLOGICAL PRECONDITIONING WITH LOW-DOSE CYCLOSPORINE OR FK506 REDUCES SUBSEQUENT ISCHEMIA/REPERFUSION INJURY IN RAT KIDNEY1,2:
CW Yang, HJ Ahn, HJ Han, WY Kim, C Li, MJ Shin, SK Kim, JH Park, YS Kim, IS Moon, BK Bang
Transplantation 2001
Overexpression of Inducible Heat Shock Protein 70 in COS-1 Cells Fails to Protect From Cytotoxicity of Oxidized LDLs
A Pirillo, GD Norata, T Zanelli, AL Catapano
Arteriosclerosis, thrombosis, and vascular biology 2001
Molecular Biology of Acute Lung Injury
HR Wong, TP Shanley
2001
Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E
A Gullo
2001
Targeted hsp70.1 Disruption Increases Infarction Volume After Focal Cerebral Ischemia in Mice
SH Lee, M Kim, BW Yoon, YJ Kim, SJ Ma, JK Roh, JS Lee, JS Seo
Stroke; a journal of cerebral circulation 2001
Thermotherapy for Neoplasia, Inflammation, and Pain
M Kosaka, T Sugahara, KL Schmidt, E Simon
2001
HSP70-mediated acceleration of translational recovery after stress is independent of ribosomal RNA synthesis
FA Nieuwenhoven, X Martin, VV Heijnen, RN Cornelussen, LH Snoeckx
European Journal of Cell Biology 2001
The involvement of cytokines in the second window of ischaemic preconditioning
N Yamashita, S Hoshida, K Otsu, N Taniguchi, T Kuzuya, M Hori
British Journal of Pharmacology 2000
Cytoprotection by electromagnetic field-induced hsp70: A model for clinical application
S Carmody, XL Wu, H Lin, M Blank, H Skopicki, R Goodman
Journal of Cellular Biochemistry 2000
Hyperthermic induction of the 27-kDa heat shock protein (Hsp27) in neuroglia and neurons of the rat central nervous system
AM Krueger-Naug, DA Hopkins, JN Armstrong, JC Plumier, RW Currie
The Journal of Comparative Neurology 2000
Impact of hyperthermic preconditioning on postischemic hepatic microcirculatory disturbances in an isolated perfusion model of the rat liver
H Terajima, G Enders, A Thiaener, C Hammer, T Kondo, J Thiery, Y Yamamoto, Y Yamaoka, K Messmer
Hepatology 2000
Overexpression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury
Z Chen, TD Oberley, YS Ho, CC Chua, B Siu, RC Hamdy, CJ Epstein, BH Chua
Free radical biology & medicine 2000
Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction
S Rajdev, K Hara, Y Kokubo, R Mestril, W Dillmann, PR Weinstein, FR Sharp
Annals of Neurology 2000
Heat shock transcription factor activation and hsp72 accumulation in aged skeletal muscle
M Locke
Cell stress & chaperones 2000
Ischemic preconditioning: Lack of delayed protection against skeletal muscle ischemia-reperfusion
DA Lepore, WA Morrison
Microsurgery 2000
The early response genes c-jun and HSP-70 are induced in regional cardiac stunning in conscious mammals
A Meissner, I Lüss, N Rolf, P Boknik, U Kirchhefer, V Kehm, J Knapp, B Linck, H Lüss, FU Müller, T Weber, W Schmitz, HV Aken, J Neumann
The Journal of Thoracic and Cardiovascular Surgery 2000
Altered ischemic induction of immediate early gene and heat shock protein 70 mRNAs after preconditioning in rat hearts
Y Nitta-Komatsubara, K Abe, M Aoki, S Isoyama
Life Sciences 2000
Preconditioning of Human Smooth Muscle Cells via Cyclopentenone Prostaglandins Protects against Toxic Effects of Oxidized Low-Density Lipoprotein
L Hamel, M Kenney, K Clark, L Merkel, C Rojas
Biochemical and Biophysical Research Communications 2000
Production and Characterization of a Monoclonal Antibody Specific to the Human 70-kDa Heat Shock Protein
DJ Kim, JH Chung, JS Lee, YI Moon, JS Seo, HK Chung
Hybridoma 2000
Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27
RW Currie, JA Ellison, RF White, GZ Feuerstein, X Wang, FC Barone
Brain Research 2000
Adaptive Responses of the Endothelium to Stress
TH Pohlman, JM Harlan
Journal of Surgical Research 2000
10 kD mitochondrial matrix heat shock protein mRNA is induced following global brain ischemia in the rat
RW Hickey, RL Zhu, HL Alexander, KL Jin, RA Stetler, J Chen, PM Kochanek, SH Graham
Molecular Brain Research 2000
Inducibility of the 70 kD heat shock protein in peripheral blood monocytes is decreased in human acute respiratory distress syndrome and recovers over time
P Durand, M Bachelet, F Brunet, MJ Richard, JF Dhainaut, J Dall'Ava, BS Polla
American journal of respiratory and critical care medicine 2000
The heat shock response inhibits NF-kappaB activation, nitric oxide synthase type 2 expression, and macrophage/microglial activation in brain
MT Heneka, A Sharp, T Klockgether, V Gavrilyuk, DL Feinstein
Journal of Cerebral Blood Flow & Metabolism 2000
Gene therapy for myocardial protection: transfection of donor hearts with heat shock protein 70 gene protects cardiac function against ischemia-reperfusion injury
J Jayakumar, K Suzuki, M Khan, RT Smolenski, A Farrell, N Latif, O Raisky, H Abunasra, IA Sammut, B Murtuza, M Amrani, MH Yacoub
Circulation 2000
Heat shock factors and the control of the stress response
MG Santoro
Biochemical Pharmacology 2000
Association of heat shock protein 70 with semen quality in boars
SY Huang, YH Kuo, YP Lee, HL Tsou, EC Lin, CC Ju, WC Lee
Animal Reproduction Science 2000
Cytoprotective Mechanism of Heat Shock Protein 70 against Hypoxia/Reoxygenation Injury
K Kawana, Y Miyamoto, K Tanonaka, Y Han-no, H Yoshida, M Takahashi, S Takeo
Journal of Molecular and Cellular Cardiology 2000
Rac1 Regulates Stress-induced, Redox-dependent Heat Shock Factor Activation
M Ozaki, SS Deshpande, P Angkeow, S Suzuki, K Irani
The Journal of biological chemistry 2000
Glucocorticoid pretreatment protects cardiac function and induces cardiac heat shock protein 72
G Valen, T Kawakami, P Tähepôld, A Dumitrescu, C Löwbeer, J Vaage
American journal of physiology. Heart and circulatory physiology 2000
Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance
J Chang, AA Knowlton, JS Wasser
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2000
Inducible Resistance to Oxidant Stress in the Protozoan Leishmania chagasi
MA Miller, SE McGowan, KR Gantt, M Champion, SL Novick, KA Andersen, CJ Bacchi, N Yarlett, BE Britigan, ME Wilson
The Journal of biological chemistry 2000
Protection against endotoxemia by HSP70 in rodent cardiomyocytes
SS Lau, TM Griffin, R Mestril
American journal of physiology. Heart and circulatory physiology 2000
Transgenic overexpression of cardiac A 1 adenosine receptors mimics ischemic preconditioning
RR Morrison, R Jones, AM Byford, AR Stell, J Peart, JP Headrick, GP Matherne
American journal of physiology. Heart and circulatory physiology 2000
Stress Proteins as Molecular Markers of Neurotoxicity
S Rajdev, FR Sharp
Toxicologic pathology 2000
A new method of long-term preventive cardioprotection using Lactobacillus
T Oxman, M Shapira, A Diver, R Klein, N Avazov, B Rabinowitz
American journal of physiology. Heart and circulatory physiology 2000
Cardioprotection by K ATP channels in wild-type hearts and hearts overexpressing A 1 -adenosine receptors
JP Headrick, NS Gauthier, R Morrison, GP Matherne
American journal of physiology. Heart and circulatory physiology 2000
Suppression of Stress Kinase JNK Is Involved in HSP72-mediated Protection of Myogenic Cells from Transient Energy Deprivation: HSP72 ALLEVIATES THE STRESS-INDUCED INHIBITION OF JNK DEPHOSPHORYLATION
VL Gabai, AB Meriin, JA Yaglom, JY Wei, DD Mosser, MY Sherman
The Journal of biological chemistry 2000
The myocardial heat shock response following sodium salicylate treatment
M Locke, J Atance
Cell Stress and Chaperones 2000
The Late Phase of Preconditioning
R Bolli
Circulation research 2000
Mechanical Stress–Induced Heat Shock Protein 70 Expression in Vascular Smooth Muscle Cells Is Regulated by Rac and Ras Small G Proteins but Not Mitogen-Activated Protein Kinases
Q Xu, G Schett, C Li, Y Hu, G Wick
Circulation research 2000
Confocal Microscopic Localization of Constitutive and Heat Shock–Induced Proteins HSP70 and HSP27 in the Rat Heart
JP Leger, FM Smith, RW Currie
Circulation 2000
Apoptosis in Cardiac Biology
H Schunkert, GA Riegger
2000
Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms
VP Skulachev
Molecular Aspects of Medicine 1999
Heat stress response and myocardial protection
M Joyeux, D Godin-Ribuot, DM Yellon, P Demenge, C Ribuot
Fundamental & Clinical Pharmacology 1999
Heat shock protein 70 (Hsp70) protects postimplantation murine embryos from the embryolethal effects of hyperthermia
PE Mirkes, LM Cornel, KL Wilson, WH Dilmann
Developmental Dynamics 1999
Heat shock protein 70 overexpression protects LLC-PK1 tubular cells from heat shock but not hypoxia
MA Turman, SL Rosenfeld
Kidney International 1999
HEAT-SHOCK PROTEINS, MOLECULAR CHAPERONES, AND THE STRESS RESPONSE: Evolutionary and Ecological Physiology
ME Feder, GE Hofmann
Annual Review of Physiology 1999
Heat stress proteins and myocardial protection: experimental model or potential clinical tool?
CC Gray, M Amrani, MH Yacoub
The International Journal of Biochemistry & Cell Biology 1999
Heat shock proteins as cellular lifeguards
M Jäättelä
Annals of Medicine 1999
Inhibition of Myocardial TNF-alpha Production by Heat Shock: A Potential Mechanism of Stress-Induced Cardioprotection against Postischemic Dysfunctiona
X Meng, A Banerjee, L Ao, DR Meldrum, BS Cain, BD Shames, AH Harken
Annals of the New York Academy of Sciences 1999
Cardiac Adaptation to Ischemia-Reperfusion Injurya
JG Kingma
Annals of the New York Academy of Sciences 1999
Stress-Response Proteins in Cardiovascular Disease
X Xiao, IJ Benjamin
The American Journal of Human Genetics 1999
An essential role for NF-κB in the cardioadaptive response to ischemia
EN Morgan, EM Boyle, W Yun, JM Griscavage-Ennis, AL Farr, TG Canty, TH Pohlman, ED Verrier
The Annals of Thoracic Surgery 1999
Constitutive hsp70 Attenuates Hydrogen Peroxide-Induced Membrane Lipid Peroxidation
CY Su, KY Chong, K Edelstein, S Lille, R Khardori, CC Lai
Biochemical and Biophysical Research Communications 1999
Aggregation of hsp70 and hsc70in vivois distinct and �temperature-dependent and their chaperone function is �directly related to non-aggregated forms
CE Angelidis, I Lazaridis, GN Pagoulatos
European Journal of Biochemistry 1999
Liposomal delivery of heat-shock protein 72 into the heart prevents endotoxin-induced myocardial contractile dysfunction
DR Meldrum, X Meng, BD Shames, B Pomerantz, KK Donnahoo, A Banerjee, AH Harken
Surgery 1999
Analysis ofhsp70gene polymorphism in allergic asthma
Y Aron, M Busson, BS Polla, D Dusser, A Lockhart, E Swierczewski, F Favatier
Allergy 1999
Role of TNF in Mediating Renal Insufficiency Following Cardiac Surgery: Evidence of a Postbypass Cardiorenal Syndrome
DR Meldrum, KK Donnahoo
Journal of Surgical Research 1999
Whole body hyperthermia: effects upon canine immune and hemostatic functions
MJ Oglesbee, K Diehl, E Crawford, R Kearns, S Krakowka
Veterinary Immunology and Immunopathology 1999
The neuroprotective potential of heat shock protein 70 (HSP70)
MA Yenari, RG Giffard, RM Sapolsky, GK Steinberg
Molecular Medicine Today 1999
Myocardial adaptation to ischaemia – the preconditioning phenomenon
R Carroll, DM Yellon
International Journal of Cardiology 1999
Induction of 72-kDa heat shock protein does not produce second window of ischemic preconditioning in rat heart
YZ Qian, NL Bernardo, MA Nayeem, J Chelliah, RC Kukreja
American journal of physiology. Heart and circulatory physiology 1999
Heat shock proteins in cardiosurgery patients
ON Demidov, VV Tyrenko, AS Svistov, YY Komarova, AI Karpishenko, BA Margulis, YL Shevchenko
European Journal of Cardio-Thoracic Surgery 1999
Differential expression of stress proteins in rat myocardium after free wheel or treadmill run training
EG Noble, A Moraska, RS Mazzeo, DA Roth, MC Olsson, RL Moore, M Fleshner
Journal of applied physiology 1999
Stress Adaptation, Prophylaxis and Treatment
DK Das
1999
Reactive Oxygen Species Play an Important Role in the Activation of Heat Shock Factor 1 in Ischemic-Reperfused Heart
J Nishizawa, A Nakai, K Matsuda, M Komeda, T Ban, K Nagata
Circulation 1999
Stress Proteins
DS Latchman
1999
Myocardial preconditioning: basic concepts and potential mechanisms
S Okubo, L Xi, N L Bernardo, K Yoshida, R C Kukreja
Molecular and Cellular Biochemistry 1999
Role of protein kinase C and 72 kDa heat shock protein in ischemic tolerance following heat stress in the rat heart
R C Kukreja, Y Z Qian, S Okubo, E E Flaherty
Molecular and Cellular Biochemistry 1999
Cardioprotection by Local Heating: Improved Myocardial Salvage After Ischemia and Reperfusion
AG MS, CY MD, GK PhD, JR MD, SR PhD, MS PhD, MM PhD
The Annals of Thoracic Surgery 1998
Stress–inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection
RI Morimoto, MG Santoro
Nature Biotechnology 1998
Stress and Work
G Schacke
Annals of the New York Academy of Sciences 1998
Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy
MA Yenari, SL Fink, GH Sun, LK Chang, MK Patel, DM Kunis, D Onley, DY Ho, RM Sapolsky, GK Steinbrg
Annals of Neurology 1998
Stress genes protect brain
FR Sharp
Annals of Neurology 1998
Heat-shock proteins and cardioprotection
IY Malyshev, EV Malysheva
Bulletin of Experimental Biology and Medicine 1998
Heat shock proteins in inflammation and asthma: Dr Jekyll or Mr Hyde?
Polla, Bachelet, Dall'ava, Vignola
Clinical & Experimental Allergy 1998
In VivoHeat Shock Protects Rat Myocardial Mitochondria
L Bornman, CM Steinmann, GS Gericke, BS Polla
Biochemical and Biophysical Research Communications 1998
The Role of Inducible 70-kDa Heat Shock Protein in Cell Cycle Control, Differentiation, and Apoptotic Cell Death of the Human Myeloid Leukemic HL-60 Cells
HJ Kwak, CD Jun, HO Pae, JC Yoo, YC Park, BM Choi, YG Na, RK Park, HT Chung, HY Chung, WY Park, JS Seo
Cellular Immunology 1998
Oxidant/Antioxidant Imbalance in Skin Aging: Environmental and Adaptative Factors
E Mariethoz, MJ Richard, LL Polla, SE Kreps, J Dal'Ava, BS Polla
Reviews on Environmental Health 1998
Heat shock protein 72 restores cyclic AMP accumulation after heat shock in N18TG2 cells
H Zensho, A Nishida, M Shimizu, Y Uchitomi, S Yamawaki
Brain Research 1998
Overexpression of HSP-70 Attenuates Increases in [Ca2+]iand Protects Human Epidermoid A-431 Cells after Chemical Hypoxia
JG Kiang, XZ Ding, DE McClain
Toxicology and Applied Pharmacology 1998
Induction of the 27-kDa Heat Shock Protein (Hsp27) in the Rat Medulla Oblongata after Vagus Nerve Injury
DA Hopkins, JC Plumier, RW Currie
Experimental Neurology 1998
Tumor necrosis factor in the heart
DR Meldrum
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 1998
Intracellular calcium dynamics in mouse model of myocardial stunning
TG Hampton, I Amende, KE Travers, JP Morgan
American journal of physiology. Heart and circulatory physiology 1998
Induction of HSP 32 gene in hypoxic cardiomyocytes is attenuated by treatment with N -acetyl- l -cysteine
DR Borger, DA Essig
American journal of physiology. Heart and circulatory physiology 1998
Specific heat shock proteins protect microtubules during simulated ischemia in cardiac myocytes
WF Bluhm, JL Martin, R Mestril, WH Dillmann
American journal of physiology. Heart and circulatory physiology 1998
Targeted Disruption of Heat Shock Transcription Factor 1 Abolishes Thermotolerance and Protection against Heat-inducible Apoptosis
DR McMillan, X Xiao, L Shao, K Graves, IJ Benjamin
The Journal of biological chemistry 1998
Tobacco smoke induces both apoptosis and necrosis in mammalian cells: differential effects of HSP70
M Vayssier, N Banzet, D François, K Bellmann, BS Polla
American journal of physiology. Lung cellular and molecular physiology 1998
Stress (Heat Shock) Proteins: Molecular Chaperones in Cardiovascular Biology and Disease
IJ Benjamin, DR McMillan
Circulation research 1998
Thermal Preconditioning Before Rat Arterial Balloon Injury: Limitation of Injury and Sustained Reduction of Intimal Thickening
DG Neschis, SD Safford, PN Raghunath, DJ Langer, ML David, AK Hanna, JE Tomaszewski, K Kariko, ES Barnathan, MA Golden
Arteriosclerosis, thrombosis, and vascular biology 1998
The Ischemic Heart
S Mochizuki, N Takeda, M Nagano, NS Dhalla
1998
Cardiovascular Biology of Purines
G Burnstock, JG Dobson, BT Liang, J Linden
1998
Cardiac Metabolism in Health and Disease
S Abdel-Aleem, JE Lowe
1998
Myocardial Ischemia and Reperfusion
MV Cohen, RJ Gelpi, JM Downey, J Slezak
1998
Delayed Preconditioning and Adaptive Cardioprotection
GF Baxter, DM Yellon
1998
Ischemic preconditioning in isolated perfused mouse heart: reduction in infarct size without improvement of post-ischemic ventricular function
L Xi, M L Hess, R C Kukreja
Molecular and Cellular Biochemistry 1998
Phospholipase A2-mediated hydrolysis of cardiac phospholipids: the use of molecular and transgenic techniques
L J De Windt, R S Reneman, G J Van der Vusse, M Van Bilsen
Molecular and Cellular Biochemistry 1998
Heat stress pretreatment mitigates postischemic arachidonic acid accumulation in rat heart
G J van der Vusse, R N Cornelussen, T H Roemen, L H Snoeckx
Molecular and Cellular Biochemistry 1998
In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat
K Suzuki, Y Sawa, Y Kaneda, H Ichikawa, R Shirakura, H Matsuda
Journal of Clinical Investigation 1997
Nitric oxide induces heat-shock protein 70 expression in vascular smooth muscle cells via activation of heat shock factor 1
Q Xu, Y Hu, R Kleindienst, G Wick
Journal of Clinical Investigation 1997
Adaptive and Maladaptive Mechanisms of Cellular Priming
DR Meldrum, JC Cleveland, EE Moore, DA Partrick, A Banerjee, AH Harken
Annals of Surgery 1997
Characterization of Human Proximal Tubular Cells after Hypoxic Preconditioning: Constitutive and Hypoxia-Induced Expression of Heat Shock Proteins HSP70 (A, B, and C), HSC70, and HSP90
MA Turman, DA Kahn, SL Rosenfeld, CA Apple, CM Bates
Biochemical and Molecular Medicine 1997
Heat Shock Response - Pathophysiological Implications
S Leppa, L Sistonen
Annals of Medicine 1997
Time Course of Delayed Myocardial Protection After Transient Adenosine A1-Receptor Activation in the Rabbit
GF Baxter, DM Yellon
Journal of Cardiovascular Pharmacology 1997
Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects
L Vígh, PN Literáti, I Horváth, Z Török, G Balogh, A Glatz, E Kovács, I Boros, P Ferdinándy, B Parkas, L Jaszlits, A Jednákovits, L Korányi, B Maresca
Nature Medicine 1997
On-Pump, Beating-Heart Coronary Artery Operations in High-Risk Patients: An Acceptable Trade-off?
LP Perrault, P Menasché, J Peynet, B Faris, A Bel, T Chaumaray, C Gatecel, B Touchot, G Bloch, JM Moalic
The Annals of Thoracic Surgery 1997
Induction of myocardial heat shock protein 70 during cardiac surgery
DP Taggart, CJ Bakkenist, SC Biddolph, AK Graham, JO McGee
The Journal of Pathology 1997
Cortical Application of Potassium Chloride Induces the Low-Molecular Weight Heat Shock Protein (Hsp27) in Astrocytes
JC Plumier, JC David, HA Robertson, RW Currie
Journal of Cerebral Blood Flow & Metabolism 1997
Adaptive and maladaptive mechanisms of cellular priming
DR Meldrum, JC Cleveland, EE Moore, DA Partrick, A Banerjee, AH Harken
Annals of Surgery 1997
Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia
GP Matherne, J Linden, AM Byford, NS Gauthier, JP Headrick
Proceedings of the National Academy of Sciences 1997
Expression of Immediate Early Genes After Cardioplegic Arrest and Reperfusion
HA MD, TC BS, TE BS, SR MD, DE MD, GA MD, HS MD
The Annals of Thoracic Surgery 1997
Constitutive expression of the 27-kDa heat shock protein (Hsp27) in sensory and motor neurons of the rat nervous system
JC Plumier, DA Hopkins, HA Robertson, RW Currie
The Journal of Comparative Neurology 1997
Bimoclomol (BRLP-42) Ameliorates Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats
K Bíró, A Jednákovits, T Kukorelli, E Hegedu″s, L Korányi
Brain Research Bulletin 1997
Mechanisms of Cardiac Preconditioning: Ten Years after the Discovery of Ischemic Preconditioning
DR Meldrum
Journal of Surgical Research 1997
Specific Intranucleolar Distribution of Hsp70 during Heat Shock in Polytene Cells
G Morcillo, E Gorab, RM Tanguay, JL Dı́ez
Experimental Cell Research 1997
Induction of the heat shock response prevents tissue injury during acute inflammation of the rat ileum:
A Stojadinovic, J Kiang, J Goldhill, D Matin, R Smallridge, R Galloway, T Shea-Donohue
Critical Care Medicine 1997
In vivo exposure to ozone produces an increase in a 72-kDa heat shock protein in guinea pigs
WY Su, T Gordon
Journal of applied physiology 1997
Differential expression of c-fos, Hsp70 and Hsp27 after photothrombotic injury in the rat brain
JC Plumier, JN Armstrong, NI Wood, JM Babity, TC Hamilton, AJ Hunter, HA Robertson, RW Currie
Brain research. Molecular brain research 1997
Delayed Coronary Endothelial Protection 24 Hours After Preconditioning: Role of Free Radicals
N Kaeffer, V Richard, C Thuillez
Circulation 1997
Abundance and Location of the Small Heat Shock Proteins HSP25 and αB-Crystallin in Rat and Human Heart
G Lutsch, R Vetter, U Offhauss, M Wieske, HJ Gröne, R Klemenz, I Schimke, J Stahl, R Benndorf
Circulation 1997
Blocking the Endogenous Increase in HSP 72 Increases Susceptibility to Hypoxia and Reoxygenation in Isolated Adult Feline Cardiocytes
M Nakano, DL Mann, AA Knowlton
Circulation 1997
Simultaneous Overexpression of Two Stress Proteins in Rat Cardiomyocytes and Myogenic Cells Confers Protection Against Ischemia-Induced Injury
S Lau, N Patnaik, MR Sayen, R Mestril
Circulation 1997
Small Heat Shock Proteins and Protection Against Ischemic Injury in Cardiac Myocytes
JL Martin, R Mestril, R Hilal-Dandan, LL Brunton, WH Dillmann
Circulation 1997
Heat stress increases cardiac HSP72i but fails to reduce myocardial infarct size in rabbits 24 hours later
LJ Saganek, DP Ignasiak, BL Batley, RE Potoczak, G Dodd, KP Gallagher
Basic Research in Cardiology 1997
Heat Shock Proteins and the Cardiovascular System
AA Knowlton
1997
Heat Shock Proteins and Cytoprotection
AE Kabakov, VL Gabai
1997
Environmental Stress, Adaptation and Evolution
R Bijlsma, V Loeschcke
1997
Reperfusion Injury: Basic Concepts and Protection Strategies
Kukreja, Janin
Journal of Thrombosis and Thrombolysis 1997
Is "Lethal Reperfusion" an Oxymoron?
Gardner
Journal of Thrombosis and Thrombolysis 1997
Characterization of cold-induced heat shock protein expression in neonatal rat cardiomyocytes
E Laios, I M Rebeyka, C A Prody
Molecular and Cellular Biochemistry 1997
Specific induction of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes. A new pharmacological route to stress protein expression?
SD Morris, DV Cumming, DS Latchman, DM Yellon
Journal of Clinical Investigation 1996
Stress activated cytokines and the heart
DL Mann
Cytokine & Growth Factor Reviews 1996
Stress proteins and atherosclerosis
P Roma, AL Catapano
Atherosclerosis 1996
Delayed protection of the ischemic heart - from pathophysiology to therapeutic applications
V Richard, N Kaeffer, C Thuillez
Fundamental & Clinical Pharmacology 1996
The effect of tumor necrosis factor-alphaon cardiac structure and function: A tale of two cytokines
DL Mann
Journal of Cardiac Failure 1996
Heat shock proteins: Applications in health and disease
S Jindal
Trends in Biotechnology 1996
Windows for HSP 70
LH Snoeckx, R Cornelussen, RS Reneman, GJ Vusse
Annals of the New York Academy of Sciences 1996
Myocardial Adaptation, Stress Proteins, and the Second Window of Protection
MS Marber, DM Yellon
Annals of the New York Academy of Sciences 1996
Preservation of the Latissimus Dorsi Muscle During Cardiomyoplasty Surgery
CD Ianuzzo, SE Ianuzzo, M Locke, C Brdlik, WA Anderson, J Gu, RE Klabunde
Journal of Cardiac Surgery 1996
Protection of the myocardium by ischaemic preconditioning: Mechanisms and therapeutic implications
CG Millar, GF Baxter, C Thiemermann
Pharmacology & Therapeutics 1996
Tumor Necrosis Factor-?-Induced Cytoprotective Mechanisms in Cardiomyocytes
HS Sharma, D Weisensee, I Löw-Friedrich
Annals of the New York Academy of Sciences 1996
Cell signaling and heat shock protein expression
JG Kiang, GC Tsokos
Journal of Biomedical Science 1996
Preconditioning Potentiates Molecular Signaling for Myocardial Adaptation to Ischemia
DK Das, N Maulik, T Yoshida, RM Engelman, YL Zu
Annals of the New York Academy of Sciences 1996
The Role of Protein Kinase C in Ischemic/Reperfused Preconditioned Isolated Rat Hearts
A Tosaki, N Maulik, DT Engelman, RM Engelman, DK Das
Journal of Cardiovascular Pharmacology 1996
Myocardial protection after monophosphoryl lipid A: studies of delayed anti-ischaemic properties in rabbit heart
GF Baxter, RW Goodwin, MJ Wright, M Kerac, RJ Heads, DM Yellon
British Journal of Pharmacology 1996
Mitochondria are selective targets for the protective effects of heat shock against oxidative injury
BS Polla, S Kantengwa, D François, S Salvioli, C Franceschi, C Marsac, A Cossarizza
Proceedings of the National Academy of Sciences 1996
Cardioprotective effects of 70-kDa heat shock protein in transgenic mice
NB Radford, M Fina, IJ Benjamin, RW Moreadith, KH Graves, P Zhao, S Gavva, A Wiethoff, AD Sherry, CR Malloy, RS Williams
Proceedings of the National Academy of Sciences 1996
Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin
MR Jacquier-Sarlin, BS Polla
Biochemical Journal 1996
The inducible 70,000molecular weight heat shock protein is expressed in the degenerating dentate hilus and piriform cortex after systemic administration of kainic acid in the rat
JN Armstrong, JC Plumier, HA Robertson, RW Currie
Neuroscience 1996
Heat shock protein hsp70 overexpression confers resistance against nitric oxide
K Bellmann, M Jäättelä, D Wissing, V Burkart, H Kolb
FEBS Letters 1996
Methods for studying experimental myocardial ischemic and reperfusion injury
SC Black, IW Rodger
Journal of Pharmacological and Toxicological Methods 1996
Heat shock proteins: A broader perspective
PL Moseley
Journal of Laboratory and Clinical Medicine 1996
Expression of the 27,000 mol. wt heat shock protein following kainic acid-induced status epilepticus in the rat
JC Plumier, JN Armstrong, J Landry, JM Babity, HA Robertson, RW Currie
Neuroscience 1996
Endotoxin induces cardiac HSP70 and resistance to endotoxemic myocardial depression in rats
X Meng, JM Brown, L Ao, SK Nordeen, W Franklin, AH Harken, A Banerjee
American journal of physiology. Cell physiology 1996
Evidence That a Rapidly Turning Over Protein, Normally Degraded by Proteasomes, Regulates hsp72 Gene Transcription in HepG2 Cells
M Zhou, X Wu, HN Ginsberg
The Journal of biological chemistry 1996
Stable expression of a human HSP70 gene in a rat myogenic cell line confers protection against endotoxin
SH Chi, R Mestril
American journal of physiology. Cell physiology 1996
Biochemical Mechanisms in Heart Function
EG Krause, R Vetter
1996
New Paradigms of Coronary Artery Disease
G Heusch, R Schulz
1996
Reperfusion Causes Significant Activation of Heat Shock Transcription Factor 1 in Ischemic Rat Heart
J Nishizawa, A Nakai, T Higashi, M Tanabe, S Nomoto, K Matsuda, T Ban, K Nagata
Circulation 1996
Activation of Heat Shock Transcription Factor 1 in Rat Aorta in Response to High Blood Pressure
Q Xu, TW Fawcett, R Udelsman, NJ Holbrook
Hypertension 1996
Overexpression of Heat Shock Protein 72 in Transgenic Mice Decreases Infarct Size In Vivo
JJ Hutter, R Mestril, EK Tam, RE Sievers, WH Dillmann, CL Wolfe
Circulation 1996
Myocardial Ischemia: Mechanisms, Reperfusion, Protection
M Karmazyn
1996
HSP25 in isolated perfused rat hearts: Localization and response to hyperthermia
B Hoch, G Lutsch, WP Schlegel, J Stahl, G Wallukat, S Bartel, EG Krause, R Benndorf, P Karczewski
Molecular and Cellular Biochemistry 1996
Monophosphoryl lipid A induces pharmacologic ?preconditioning? in rabbit hearts without concomitant expression of 70-kDa heat shock protein
K Yoshida, MM Maaieh, JB Shipley, M Doloresco, NL Bernardo, YZ Qian, GT Elliott, RC Kukreja
Molecular and Cellular Biochemistry 1996
Monophosphoryl lipid A induces pharmacologic ?preconditioning? in rabbit hearts without concomitant expression of 70-kDa heat shock protein
K Yoshida, MM Maaieh, JB Shipley, M Doloresco, NL Bernardo, YZ Qian, GT Elliott, RC Kukreja
Molecular and Cellular Biochemistry 1996
Pharmacological preconditioning of primary rat cardiac myocytes by FK506
D V Cumming, R J Heads, R S Coffin, D M Yellon, D S Latchman
Basic Research in Cardiology 1996
Delayed myocardial protection following ischaemic preconditioning
G F Baxter, D M Yellon
Basic Research in Cardiology 1996
Myocardial Self-Preservation: Absence of Heat Shock Factor Activation and Heat Shock Proteins 70 mRNA Accumulation in the Human Heart During Cardiac Surgery
LB McGrath, M Locke
Journal of Cardiac Surgery 1995
Catalase Inhibition With 3-Amino-1,2,4-Triazole Does Not Abolish Infarct Size Reduction in Heat-Shocked Rats
Y Auyeung, RE Sievers, D Weng, V Barbosa, CL Wolfe
Circulation 1995
Stress-Inducible Cellular Responses
U Feige, I Yahara, RI Morimoto, BS Polla
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Leukotrienes
J Ophir, S Brenner, S Kivity
International Journal of Dermatology 1985
Hypoxia
EA Oppenheimer, JR Esterly, JF Moran, M Jevtic
The American Journal of Medicine 1970

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