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Citations to this article

Skeletal muscle utilization of free fatty acids in women with visceral obesity.
S R Colberg, … , F L Thaete, D E Kelley
S R Colberg, … , F L Thaete, D E Kelley
Published April 1, 1995
Citation Information: J Clin Invest. 1995;95(4):1846-1853. https://doi.org/10.1172/JCI117864.
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Research Article

Skeletal muscle utilization of free fatty acids in women with visceral obesity.

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Abstract

Authors

S R Colberg, J A Simoneau, F L Thaete, D E Kelley

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Splanchnic lipolysis in human obesity
Soren Nielsen, ZengKui Guo, C. Michael Johnson, Donald D. Hensrud, Michael D. Jensen
Journal of Clinical Investigation 2004
Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review
ES Freedland
Nutrition & Metabolism 2004
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
H Bays, L Mandarino, RA DeFronzo
The Journal of clinical endocrinology and metabolism 2004
The case of visceral fat: argument for the defense
S Klein
Journal of Clinical Investigation 2004
Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus
EE Blaak
Proceedings of the Nutrition Society 2004
Postexercise Muscle Triacylglycerol and Glycogen Metabolism in Obese Insulin-Resistant Zucker Rats**
CR Bruce, JS Lee, B Kiens, JA Hawley
Obesity 2004
Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle
DK Richardson, S Kashyap, M Bajaj, K Cusi, SJ Mandarino, J Finlayson, RA DeFronzo, CP Jenkinson, LJ Mandarino
The Journal of biological chemistry 2004
Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II
LW Castellani, P Gargalovic, M Febbraio, S Charugundla, ML Jien, AJ Lusis
Journal of lipid research 2004
Effects of insulin resistance on substrate utilization during exercise in overweight women
B Braun, C Sharoff, SR Chipkin, F Beaudoin
Journal of applied physiology 2004
Impaired ?-adrenergically mediated lipolysis in skeletal muscle of obese subjects
EE Blaak, SL Schiffelers, WH Saris, M Mensink, ME Kooi
Diabetologia 2004
Physiological factors that regulate the use of endogenous fat and carbohydrate fuels during endurance exercise
B Mittendorfer, S Klein
Nutrition Research Reviews 2003
Fatty acid metabolism in obesity and type 2 diabetes mellitus
EE Blaak
Proceedings of the Nutrition Society 2003
The role of intramuscular lipid in insulin resistance
BD Hegarty, SM Furler, J Ye, GJ Cooney, EW Kraegen
Acta Physiologica Scandinavica 2003
Adipose tissue quantification by imaging methods: a proposed classification
W Shen, ZM Wang, M Punyanita, J Lei, A Sinav, JG Kral, C Imielinska, R Ross, SB Heymsfield
Obesity research 2003
Effects of a two-month rehabilitation program on substrate utilization during exercise in obese adolescents
F Brandou, M Dumortier, P Garandeau, J Mercier, JF Brun
Diabetes & Metabolism 2003
Handbook of Obesity: Etiology and Pathophysiology, Second Edition
R Pasquali, V Vicennati, U Pagotto
Handbook of Obesity: Etiology and Pathophysiology, Second Edition 2003
Anomalies musculaires dans l'obésité et le diabète de type 2: Intérêt de l'activité physique
J Mercier, M Dumortier
Revue Française des Laboratoires 2003
Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men
I Glisezinski, C Moro, F Pillard, F Marion-Latard, I Harant, M Meste, M Berlan, F Crampes, D Rivière
American journal of physiology. Endocrinology and metabolism 2003
Nonnutritive flow impairs uptake of fatty acid by white muscles of the perfused rat hindlimb
LH Clerk, ME Smith, S Rattigan, MG Clark
American journal of physiology. Endocrinology and metabolism 2003
Na + -K + -ATPase α2-gene and skeletal muscle characteristics in response to long-term overfeeding
O Ukkola, DR Joanisse, A Tremblay, C Bouchard
Journal of applied physiology 2003
Muscle Lipid Metabolism and Insulin Secretion Are Altered in Insulin-Resistant Rats Fed a High Sucrose Diet
A Chicco, ME D'Alessandro, L Karabatas, C Pastorale, JC Basabe, YB Lombardo
The Journal of nutrition 2003
Effects of free fatty acids on insulin secretion in obesity
S Zraika, M Dunlop, J Proietto, S Andrikopoulos
Obesity Reviews 2002
Skeletal Muscle Triglycerides
DE Kelley
Annals of the New York Academy of Sciences 2002
MUSCLETRIGLYCERIDE ANDINSULINRESISTANCE
DE Kelley, BH Goodpaster, L Storlien
Annual Review of Nutrition 2002
Skeletal muscle triglyceride: Marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?
BH Goodpaster, DE Kelley
Current Diabetes Reports 2002
Substrate oxidation, obesity and exercise training
EE Blaak, WH Saris
Best Practice & Research Clinical Endocrinology & Metabolism 2002
Role of leptin in glucose metabolism in type 2 diabetes
N Al-Daghri, WA Bartlett, AF Jones, S Kumar
Diabetes, Obesity and Metabolism 2002
Peroxisome proliferator activated receptors, fatty acids and muscle insulin resistance
E Kraegen, G Cooney, JM Ye, S Furler
Journal of the Royal Society of Medicine 2002
Influence of Racial Origin and Skeletal Muscle Properties on Disease Prevalence and Physical Performance
RR Suminski, CO Mattern, ST Devor
Sports Medicine 2002
M USCLE T RIGLYCERIDE AND I NSULIN R ESISTANCE
DE Kelley, BH Goodpaster, L Storlien
Annual Review of Nutrition 2002
Insulin Resistance and Insulin Resistance Syndrome
A Cincotta
Insulin Resistance and Insulin Resistance Syndrome 2002
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
GF Lewis, A Carpentier, K Adeli, A Giacca
Endocrine reviews 2002
The metabolic syndrome
O Bosello, M Zamboni
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 2002
The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 Expression
P Schrauwen, DP van Aggel-Leijssen, G Hul, AJ Wagenmakers, H Vidal, WH Saris, MA van Baak
Diabetes 2002
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
DE Kelley, J He, EV Menshikova, VB Ritov
Diabetes 2002
Expression and regulation by insulin of low-density lipoprotein receptor-related protein mRNA in human skeletal muscle
P Boucher, PH Ducluzeau, P Davelu, F Andreelli, P Vallier, JP Riou, M Laville, H Vidal
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2002
Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation
G Perseghin, P Scifo, M Danna, A Battezzati, S Benedini, E Meneghini, AD Maschio, L Luzi
American journal of physiology. Endocrinology and metabolism 2002
Effect of exercise training at different intensities on fat metabolism of obese men
DP van Aggel-Leijssen, WH Saris, AJ Wagenmakers, JM Senden, MA van Baak
Journal of applied physiology 2002
Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance
GR Steinberg, ML Parolin, GJ Heigenhauser, DJ Dyck
American journal of physiology. Endocrinology and metabolism 2002
Fuel oxidation during exercise in middle-aged men: role of training and glucose disposal:
J Manetta, JF Brun, A Perez-Martin, A Callis, C Prefaut, J Mercier
Medicine and Science in Sports and Exercise 2002
Influence of Racial Origin and Skeletal Muscle Properties on Disease Prevalence and Physical Performance:
RR Suminski, CO Mattern, ST Devor
Sports Medicine 2002
Fatty Acids and Adipose Tissue Distribution as Determinants of Skeletal Muscle Insulin Resistance in Type 2 Diabetes
David E. Kelley, Katherine V. Williams, Julie C. Price, Therese M. McKolanis, Bret H. Goodpaster, F. Lee Thaete
2001
Adipose tissue and the insulin resistance syndrome
KN Frayn
Proceedings of the Nutrition Society 2001
Insulin resistance and associated metabolic abnormalities in muscle: effects of exercise
A Perez-Martin, E Raynaud, J Mercier
Obesity Reviews 2001
Physiopathologie de l'obésité
C Binnert, L Tappy
Nutrition Clinique et Métabolisme 2001
The Effect of Low-Intensity Exercise Training on Fat Metabolism of Obese Women
DP van Aggel-Leijssen, WH Saris, AJ Wagenmakers, GB Hul, MA van Baak
Obesity research 2001
The effects of increasing exercise intensity on muscle fuel utilisation in humans
LJ van Loon, PL Greenhaff, D Constantin-Teodosiu, WH Saris, AJ Wagenmakers
The Journal of Physiology 2001
Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle
SE Campbell, MA Febbraio
American journal of physiology. Endocrinology and metabolism 2001
Fatty acid oxidation in African-American and Caucasian women during physical activity
RC Hickner, J Privette, K McIver, H Barakat
Journal of applied physiology 2001
The effect of an increased free fatty acid concentration on thermogenesis and substrate oxidation in obese and lean men
SL Schiffelers, WH Saris, MA Baak
International Journal of Obesity 2001
β-Adrenoceptor-mediated thermogenesis and lipolysis in patients with chronic obstructive pulmonary disease
SL Schiffelers, EE Blaak, EM Baarends, MA van Baak, WH Saris, EF Wouters, AM Schols
American journal of physiology. Endocrinology and metabolism 2001
The effect of exercise training on β-adrenergic stimulation of fat metabolism in obese men
DP Aggel-Leijssen, WH Saris, M Homan, MA Baak
International Journal of Obesity 2001
The Role of Fat Depletion in the Biological Benefits of Caloric Restriction
N Barzilai, I Gabriely
The Journal of nutrition 2001
Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers
MK Hesselink, HA Keizer, LB Borghouts, G Schaart, CF Kornips, LJ Slieker, KW Sloop, WH Saris, P Schrauwen
The FASEB Journal 2001
beta-adrenoceptor-stimulated lipolysis of subcutaneous abdominal adipocytes as a determinant of fat oxidation in obese men
Imbeault, Tremblay, Despres, Mauriege
European Journal of Clinical Investigation 2000
Visceral obesity and metabolic syndrome
O Bosello, M Zamboni
Obesity Reviews 2000
Sarcopenia: Current Concepts
R Roubenoff, VA Hughes
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2000
Metabolic imprinting on genetically predisposed neural circuits perpetuates obesity
BE Levin
Nutrition 2000
Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans
C Binnert, HA Koistinen, G Martin, F Andreelli, P Ebeling, VA Koivisto, M Laville, J Auwerx, H Vidal
American journal of physiology. Endocrinology and metabolism 2000
Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle
EE Blaak, AJ Wagenmakers, JF Glatz, BH Wolffenbuttel, GJ Kemerink, CJ Langenberg, GA Heidendal, WH Saris
American journal of physiology. Endocrinology and metabolism 2000
Oxidation of nonplasma fatty acids during exercise is increased in women with abdominal obesity
JF Horowitz, S Klein
Journal of applied physiology 2000
Lipid oxidation is reduced in obese human skeletal muscle
JY Kim, RC Hickner, RL Cortright, GL Dohm, JA Houmard
American journal of physiology. Endocrinology and metabolism 2000
Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance
DE Kelley, FL Thaete, F Troost, T Huwe, BH Goodpaster
American journal of physiology. Endocrinology and metabolism 2000
Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats
CH Kim, JH Youn, JY Park, SK Hong, KS Park, SW Park, KI Suh, KU Lee
American journal of physiology. Endocrinology and metabolism 2000
Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus
BH Goodpaster, FL Thaete, DE Kelley
The American journal of clinical nutrition 2000
Fat and carbohydrate balances during adaptation to a high-fat diet
SR Smith, L de Jonge, JJ Zachwieja, H Roy, T Nguyen, JC Rood, MM Windhauser, GA Bray
The American journal of clinical nutrition 2000
Obesity: Pathology and Therapy
DH Lockwood, TC Heffner
2000
Regulation of plasma fatty acid metabolism
J Saleh, AD Sniderman, K Cianflone
Clinica Chimica Acta 1999
Interaction between Aging and Syndrome X: New Insights on the Pathophysiology of Fat Distribution
N Barzilai, G Gupta
Annals of the New York Academy of Sciences 1999
Plasma aldosterone, plasma lipoproteins, obesity and insulin resistance in humans
TL Goodfriend, BM Egan, DE Kelley
Prostaglandins, Leukotrienes and Essential Fatty Acids 1999
Visceral Obesity and Insulin Resistance Are Associated with Plasma Aldosterone Levels in Women
TL Goodfriend, DE Kelley, BH Goodpaster, SJ Winters
Obesity research 1999
Racial Differences in Metabolic Predictors of Obesity among Postmenopausal Women
BJ Nicklas, DM Berman, DC Davis, CL Dobrovolny, KE Dennis
Obesity research 1999
Lack of skeletal muscle uncoupling protein 2 and 3 mRNA induction during fasting in type-2 diabetic subjects
H Vidal, D Langin, F Andreelli, L Millet, D Larrouy, M Laville
American journal of physiology. Endocrinology and metabolism 1999
Leptin opposes insulin’s effects on fatty acid partitioning in muscles isolated from obese ob/ob mice
DM Muoio, GL Dohm, EB Tapscott, RA Coleman
American journal of physiology. Endocrinology and metabolism 1999
Systemic resistance to the antilipolytic effect of insulin in black and white women with visceral obesity
JB Albu, M Curi, M Shur, L Murphy, DE Matthews, FX Pi-Sunyer
American journal of physiology. Endocrinology and metabolism 1999
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
DE Kelley, B Goodpaster, RR Wing, JA Simoneau
American journal of physiology. Endocrinology and metabolism 1999
Insulin regulation of glucose transport and phosphorylation in skeletal muscle assessed by PET
DE Kelley, KV Williams, JC Price
American journal of physiology. Endocrinology and metabolism 1999
Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss
JA Simoneau, JH Veerkamp, LP Turcotte, DA Kelley
The FASEB Journal 1999
Protein restriction during early development enhances insulin responsiveness but selectively impairs sensitivity to insulin at low concentrations in white adipose tissue during a later pregnancy
MJ Holness, LG Fryer, MC Sugden
British Journal of Nutrition 1999
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
N Barzilai, S Banerjee, M Hawkins, W Chen, L Rossetti
Journal of Clinical Investigation 1998
Role of muscle in triglyceride metabolism
BH Goodpaster, DE Kelley
Current Opinion in Lipidology 1998
Overexpression of muscle uncoupling protein 2 content in human obesity associates with reduced skeletal muscle lipid utilization
JA Simoneau, DE Kelley, M Neverova, CH Warden
The FASEB Journal 1998
Polymorphism of the β3-adrenergic-receptor gene associated with maternal body weight gain and fetal body weight
M Arakawa, T Kurabayashi, M Tomita, T Yahata, K Takakuwa, K Tanaka
International Journal of Gynecology & Obstetrics 1998
Aldosterone in obesity
TL Goodfriend, BM Egan, DE Kelley
Endocrine Research 1998
Fat balance in obese subjects: role of glycogen stores
P Schrauwen, WD van Lichtenbelt, WH Saris, KR Westerterp
American journal of physiology. Endocrinology and metabolism 1998
Insulin Resistance in Hypertension Is Associated With Body Fat Rather Than Blood Pressure
I Toft, KH Bønaa, T Jenssen
Hypertension 1998
Dietary Fats and Thermogenesis
A Tremblay, C Bouchard
Annals of the New York Academy of Sciences 1997
Fat and Energy Balance
MJ Pagliassotti, EC Gayles, JO Hill
Annals of the New York Academy of Sciences 1997
Food, obesity and non-insulin-dependent diabetes: are there molecular links?
JB Prins
Proceedings of the Nutrition Society 1997
Body Fat Distribution Predicts Cardiac Risk Factors in Older Female Coronary Patients
SJ Ross, ET Poehlman, RK Johnson, PA Ades
Journal of Cardiopulmonary Rehabilitation 1997
Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise
EF Coyle, AE Jeukendrup, AJ Wagenmakers, WH Saris
American journal of physiology. Endocrinology and metabolism 1997
Clinical Research in Diabetes and Obesity
B Draznin, R Rizza
1997
EXERCISE AS TREATMENT FOR OBESITY
JJ Zachwieja
Endocrinology & Metabolism Clinics of North America 1996
A malonyl-CoA fuel sensing mechanism in muscle: effects of insulin, glucose and denervation
AJ Wagenmakers
Clinical Nutrition 1996
Physical Inactivity and Metabolic Factors as Predictors of Weight Gain
WH Saris
Nutrition Reviews 1996
Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM
LJ Mandarino, A Consoli, A Jain, DE Kelley
American journal of physiology. Endocrinology and metabolism 1996
Utilization of glycogen but not plasma glucose is reduced in individuals with NIDDM during mild-intensity exercise
SR Colberg, JM Hagberg, SD McCole, JM Zmuda, PD Thompson, DE Kelley
Journal of applied physiology 1996
Differential effects of acute hypertriglyceridemia on insulin action and insulin receptor autophosphorylation
B Gumbiner, JF Mucha, JE Lindstrom, I Rekhi, JN Livingston
American journal of physiology. Endocrinology and metabolism 1996
Insulin-Resistant Lipolysis in Abdominally Obese Hypertensive Individuals: Role of the Renin-Angiotensin System
MM Hennes, IM O'Shaughnessy, TM Kelly, P LaBelle, BM Egan, AH Kissebah
Hypertension 1996
The β 3 ‐adrenoceptor: an advance in the understanding of obesity and insulin resistance
R Donnelly
The Medical Journal of Australia 1996
Impaired muscle fat metabolism: a cause or effect of visceral obesity?
RR Henry
Journal of Clinical Investigation 1995
Reduced expression of hexokinase II in insulin-resistant diabetes
DE Kelley, MA Mintun, SC Watkins, JA Simoneau, F Jadali, A Fredrickson, J Beattie, R Thériault
Journal of Clinical Investigation 1995
Association of a Polymorphism in the β<sub>3</sub>-Adrenergic–Receptor Gene with Features of the Insulin Resistance Syndrome in Finns
E Widén, M Lehto, T Kanninen, J Walston, AR Shuldiner, LC Groop
New England Journal of Medicine 1995
Reduced expression of hexokinase II in insulin-resistant diabetes
DE Kelley, MA Mintun, SC Watkins, JA Simoneau, F Jadali, A Fredrickson, J Beattie, R Thériault
Diabetes 1995
Reduced expression of hexokinase II in insulin-resistant diabetes
DE Kelley, MA Mintun, SC Watkins, JA Simoneau, F Jadali, A Fredrickson, J Beattie, R Thériault
Diabetes 1995
Insulin Resistance
A Voll, J Kloster
Acta Medica Scandinavica 1957

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