The origin of myofibroblasts in stromal reaction has been a subject of controversy. To address this question definitively, we developed techniques for purification and characterization of major stromal cell types. We defined a panel of markers that could, in combination, unequivocally distinguish these cell types by immunocytochemistry, iso-electric focusing, immunoblotting, and two-dimensional gel electrophoresis. We then devised an assay to recapitulate in culture, within two weeks of incubation, critical aspects of the microenvironment in vivo including the typical tissue histology and stromal reaction. When confronted with tumor cells in this assay, fibroblasts readily converted into a graded pattern of myogenic differentiation, strongest in the immediate vicinity of tumor cells. Vascular smooth muscle cells (VSMC), in contrast, did not change appreciably and remained coordinately smooth muscle differentiated. Midcapillary pericytes showed only a slight propensity for myogenic differentiation. Analysis of ten primary tumors implicated converted fibroblasts (10/10), vascular smooth muscle cells (4/10), and pericytes (1/10) in the stromal reaction. Tumor cells were shown to specifically denude the venules both in culture and in vivo, explaining the VSMC phenotype in the stroma. The establishment of this assay and clarification of the origin of these cells pave the way for further analysis of the mechanisms of conversion, and of the consequence of such heterogeneity for diagnosis and treatment.
L Rønnov-Jessen, O W Petersen, V E Koteliansky, M J Bissell
Title and authors | Publication | Year |
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The impact of tumor microenvironment: unraveling the role of physical cues in breast cancer progression.
Akinpelu A, Akinsipe T, Avila LA, Arnold RD, Mistriotis P |
Cancer metastasis reviews | 2024 |
Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer.
Bagger MM, Sjölund J, Kim J, Kohler KT, Villadsen R, Jafari A, Kassem M, Pietras K, Rønnov-Jessen L, Petersen OW |
Breast Cancer Research | 2024 |
Exploring the multifaceted role of direct interaction between cancer cells and fibroblasts in cancer progression
Dhungel N, Dragoi AM |
Frontiers in Molecular Biosciences | 2024 |
FGFR-related phenotypic and functional profile of CAFs in prognostication of breast cancer (Review)
Solek J, Braun M, Sadej R, Romanska HM |
International Journal of Oncology | 2024 |
3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity
Desigaux T, Comperat L, Dusserre N, Stachowicz ML, Lea M, Dupuy JW, Vial A, Molinari M, Fricain JC, Paris F, Oliveira H |
Bioactive Materials | 2024 |
Breast pericytes: a newly identified driver of tumor cell proliferation
Del Toro K, Licon-Munoz Y, Crabtree W, Oper T, Robbins C, Hines WC |
Frontiers in Oncology | 2024 |
CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer.
Houthuijzen JM, de Bruijn R, van der Burg E, Drenth AP, Wientjens E, Filipovic T, Bullock E, Brambillasca CS, Pulver EM, Nieuwland M, de Rink I, van Diepen F, Klarenbeek S, Kerkhoven R, Brunton VG, Scheele CLGJ, Boelens MC, Jonkers J |
Nature Communications | 2023 |
In Vivo Detection of Circulating Cancer-Associated Fibroblasts in Breast Tumor Mouse Xenograft: Impact of Tumor Stroma and Chemotherapy.
Lu T, Oomens L, Terstappen LWMM, Prakash J |
Cancers | 2023 |
Crosstalk between colorectal cancer cells and cancer-associated fibroblasts in the tumor microenvironment mediated by exosomal noncoding RNAs.
Sun S, Zhang Y, Li Y, Wei L |
Frontiers in immunology | 2023 |
The role of cancer-associated fibroblasts in breast cancer metastasis
Li Y, Wang C, Huang T, Yu X, Tian B |
Frontiers in Oncology | 2023 |
The Influence of Betulin Derivatives EB5 and ECH147 on the Expression of Selected TGFβ Superfamily Genes, TGFβ1, GDF15 and BMP2, in Renal Proximal Tubule Epithelial Cells.
Kubica S, Szota-Czyż J, Strzałka-Mrozik B, Adamska J, Bębenek E, Chrobak E, Gola JM |
Current issues in molecular biology | 2023 |
Fibroblasts in cancer: Unity in heterogeneity
Chhabra Y, Weeraratna AT |
Cell | 2023 |
Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities
D Hu, Z Li, B Zheng, , Y Pan, P Gong, W Zhuo, Y Hu, C Chen, L Chen, J Zhou, L Wang |
2022 | |
Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer.
Beeghly GF, Amofa KY, Fischbach C, Kumar S |
Annual Review of Biomedical Engineering | 2022 |
Cellular Plasticity and Heterotypic Interactions during Breast Morphogenesis and Cancer Initiation
Ingthorsson S, Traustadottir GA, Gudjonsson T |
Cancers | 2022 |
Revisiting laminin and extracellular matrix remodeling in metastatic squamous cell carcinoma: What have we learned after more than four decades of research?
Aleman JD, Young CD, Karam SD, Wang XJ |
Molecular Carcinogenesis | 2022 |
Stem cells for organoids
Qian S, Mao J, Liu Z, Zhao B, Zhao Q, Lu B, Zhang L, Mao X, Cheng L, Cui W, Zhang Y, Sun X |
Smart Medicine | 2022 |
Cancer-Associated Fibroblasts in the Breast Tumor Microenvironment
MB Giorello, FR Borzone, V Labovsky, FV Piccioni, NA Chasseing |
Journal of Mammary Gland Biology and Neoplasia | 2021 |
Engineering stromal heterogeneity in cancer
LJ Tang, A Zaseela, CC Toh, C Adine, AO Aydar, NG Iyer, EL Fong |
Advanced Drug Delivery Reviews | 2021 |
Fibroblast heterogeneity in prostate carcinogenesis
S ChallaSivaKanaka, R Vickman, M Kakarla, S Hayward, O Franco |
Cancer Letters | 2021 |
Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model
Miyazaki Y, Oda T, Inagaki Y, Kushige H, Saito Y, Mori N, Takayama Y, Kumagai Y, Mitsuyama T, Kida YS |
Scientific Reports | 2021 |
Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis
Y Tao, F Shao, M Cai, Z Liu, Y Peng, Q Huang, F Meng |
Frontiers in Oncology | 2021 |
COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells
YH Wu, YF Huang, TH Chang, CC Chen, PY Wu, SC Huang, CY Chou |
Oncogene | 2021 |
Fibroblast heterogeneity in prostate carcinogenesis
S ChallaSivaKanaka, RE Vickman, M Kakarla, SW Hayward, OE Franco |
Cancer Letters | 2021 |
Shaping Up the Tumor Microenvironment With Cellular Fibronectin
G Efthymiou, A Saint, M Ruff, Z Rekad, D Ciais, EV Obberghen-Schilling |
Frontiers in Oncology | 2020 |
Cancer-Associated Fibroblasts: Understanding Their Heterogeneity
K Louault, RR Li, YA DeClerck |
Cancers | 2020 |
Tumor Microenvironment: Signaling Pathways – Part A
A Birbrair |
2020 | |
Tumor Microenvironment: Signaling Pathways – Part A
A Birbrair |
2020 | |
Tumor Microenvironment: Signaling Pathways – Part A
A Birbrair |
2020 | |
Tumor Microenvironment: Signaling Pathways – Part A
A Birbrair |
2020 | |
Tumor Microenvironment: Signaling Pathways – Part A
A Birbrair |
2020 | |
Tumor Microenvironment: Signaling Pathways – Part A
A Birbrair |
2020 | |
Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination
A Avagliano, G Fiume, MR Ruocco, N Martucci, E Vecchio, L Insabato, D Russo, A Accurso, S Masone, S Montagnani, A Arcucci |
Cancers | 2020 |
Interleukin-36 Cytokine/Receptor Signaling: A New Target for Tissue Fibrosis
E Melton, H Qiu |
International journal of molecular sciences | 2020 |
Effect of naive and cancer-educated fibroblasts on colon cancer cell circadian growth rhythm
A Parascandolo, R Bonavita, R Astaburuaga, A Sciuto, S Reggio, E Barra, F Corcione, M Salvatore, G Mazzoccoli, A Relógio, MO Laukkanen |
Cell Death and Disease | 2020 |
Three-dimensional models of breast cancer–fibroblasts interactions
S Singh, S Tran, J Putman, H Tavana |
Experimental biology and medicine (Maywood, N.J.) | 2020 |
Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer
SZ Wu, DL Roden, C Wang, H Holliday, K Harvey, AS Cazet, KJ Murphy, B Pereira, G AlEryani, N Bartonicek, R Hou, JR Torpy, S Junankar, CL Chan, CE Lam, MN Hui, L Gluch, J Beith, A Parker, E Robbins, D Segara, C Mak, C Cooper, S Warrier, A Forrest, J Powell, S O'Toole, TR Cox, P Timpson, E Lim, XS Liu, A Swarbrick |
The EMBO Journal | 2020 |
Review of cancer-associated fibroblasts and their microenvironment in post-chemotherapy recurrence
G Ishii, T Ishii |
Human Cell | 2020 |
Fibroblasts direct differentiation of human breast epithelial progenitors
M Morsing, J Kim, R Villadsen, N Goldhammer, A Jafari, M Kassem, OW Petersen, L Rønnov-Jessen |
Breast Cancer Research | 2020 |
Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis
Y Cao, W Cao, Y Qiu, Y Zhou, Q Guo, Y Gao, N Lu |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2020 |
Adipose‐derived mesenchymal stem cells differentiate into pancreatic cancer‐associated fibroblasts in vitro
Y Miyazaki, T Oda, N Mori, YS Kida |
FEBS Open Bio | 2020 |
Cancer-Associated Fibroblasts: Epigenetic Regulation and Therapeutic Intervention in Breast Cancer
YT Lee, YJ Tan, M Falasca, CE Oon |
Cancers | 2020 |
Cancer-associated fibroblasts: how do they contribute to metastasis?
MQ Kwa, KM Herum, C Brakebusch |
Clinical & Experimental Metastasis | 2019 |
Giulio Gabbiani and the discovery of myofibroblasts
D Ribatti, R Tamma |
Inflammation Research | 2019 |
Crosstalk between cancer‐associated fibroblasts and immune cells in cancer
Y An, F Liu, Y Chen, Q Yang |
Journal of Cellular and Molecular Medicine | 2019 |
Molecular pathways regulated by areca nut in the etiopathogenesis of oral submucous fibrosis
P Kondaiah, I Pant, I Khan |
Periodontology 2000 | 2019 |
The breast tumor microenvironment: role in cancer development, progression and response to therapy
S Mittal, NJ Brown, I Holen |
Expert Review of Molecular Diagnostics | 2018 |
Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene
P Zhang, Y Guan, J Chen, X Li, BK McConnell, W Zhou, KM Boini, Y Zhang |
Cell Death and Disease | 2018 |
Modeling triple-negative breast cancer heterogeneity: Effects of stromal macrophages, fibroblasts and tumor vasculature
KA Norton, K Jin, AS Popel |
Journal of Theoretical Biology | 2018 |
Role of Stromal Paracrine Signals in Proliferative Diseases of the Aging Human Prostate
K Ishii, S Takahashi, Y Sugimura, M Watanabe |
Journal of Clinical Medicine | 2018 |
TGFβ1-induced expression of caldesmon mediates epithelial-mesenchymal transition
SM Nalluri, JW O'Connor, GA Virgi, SE Stewart, D Ye, EW Gomez |
Cytoskeleton (Hoboken, N.J.) | 2018 |
Using deep convolutional neural networks to identify and classify tumor-associated stroma in diagnostic breast biopsies
BE Bejnordi, M Mullooly, RM Pfeiffer, S Fan, PM Vacek, DL Weaver, S Herschorn, LA Brinton, B van Ginneken, N Karssemeijer, AH Beck, GL Gierach, JA van der Laak, ME Sherman |
Modern Pathology | 2018 |
Effects of 3-Tetrazolyl Methyl-3-Hydroxy-Oxindole Hybrid (THOH) on Cell Proliferation, Apoptosis, and G2/M Cell Cycle Arrest Occurs by Targeting Platelet-Derived Growth Factor D (PDGF-D) and the MEK/ERK Signaling Pathway in Human Lung Cell Lines SK-LU-1, A549, and A-427
P Li, Z Zhang, F Zhang, H Zhou, B Sun |
Medical science monitor : international medical journal of experimental and clinical research | 2018 |
Circular RNAs: Biogenesis and Functions
J Xiao |
2018 | |
Thermodynamic Aspects and Reprogramming Cellular Energy Metabolism during the Fibrosis Process
A Vallée, Y Lecarpentier, JN Vallée |
International journal of molecular sciences | 2017 |
Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth
TG Pestell, X Jiao, M Kumar, AR Peck, M Prisco, S Deng, Z Li, A Ertel, MC Casimiro, X Ju, AD Rocco, GD Sante, S Katiyar, A Shupp, MP Lisanti, P Jain, K Wu, H Rui, DC Hooper, Z Yu, AR Goldman, DW Speicher, L Laury-Kleintop, RG Pestell |
Oncotarget | 2017 |
Organotypic three-dimensional assays based on human leiomyoma–derived matrices
T Salo, MR Dourado, E Sundquist, EH Apu, I Alahuhta, K Tuomainen, J Vasara, A Al-Samadi |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2017 |
Mechanisms of Molecular Carcinogenesis – Volume 2
J Haybaeck |
Mechanisms of Molecular Carcinogenesis – Volume 2 | 2017 |
Engineering 3D Tissue Test Systems
KJ Burg, D Dréau, T Burg |
Engineering 3D Tissue Test Systems | 2017 |
Identification of differentially expressed genes regulated by molecular signature in breast cancer-associated fibroblasts by bioinformatics analysis
B Vastrad, C Vastrad, A Tengli, S Iliger |
Archives of Gynecology and Obstetrics | 2017 |
Advances in multicellular spheroids formation
X Cui, Y Hartanto, H Zhang |
Journal of The Royal Society Interface | 2017 |
Silencing of TGF-β1 in tumor cells impacts MMP-9 in tumor microenvironment
LD Moore-Smith, T Isayeva, JH Lee, A Frost, S Ponnazhagan |
Scientific Reports | 2017 |
Multicellular tumor invasion and plasticity in biomimetic materials
SE Leggett, AS Khoo, IY Wong |
Biomaterials Science | 2017 |
A novel method to generate single-cell-derived cancer-associated fibroblast clones
H Hashimoto, Y Suda, T Miyashita, A Ochiai, M Tsuboi, K Masutomi, T Kiyono, G Ishii |
Journal of Cancer Research and Clinical Oncology | 2017 |
Inhibition of human lung cancer proliferation through targeting stromal fibroblasts by dihydromyricetin
KJ Fan, B Yang, Y Liu, XD Tian, B Wang |
Molecular medicine reports | 2017 |
Reactive oxygen species and fibrosis: further evidence of a significant liaison
K Richter, T Kietzmann |
Cell and Tissue Research | 2016 |
Carcinoma-associated fibroblasts: orchestrating the composition of malignancy
P Gascard, TD Tlsty |
Genes & development | 2016 |
Preclinical rationale for TGF-β inhibition as a therapeutic target for the treatment of myelofibrosis
I Ceglia, AC Dueck, F Masiello, F Martelli, W He, G Federici, EF Petricoin, A Zeuner, C Iancu-Rubin, R Weinberg, R Hoffman, J Mascarenhas, AR Migliaccio |
Experimental Hematology | 2016 |
Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications
A Qiao, F Gu, X Guo, X Zhang, L Fu |
Frontiers of Medicine | 2016 |
The Interaction Between Human Papillomaviruses and the Stromal Microenvironment.
Woodby B, Scott M, Bodily J |
Progress in molecular biology and translational science | 2016 |
Molecular Pathogenesis of Pancreatic Cancer
Grant TJ, Hua K, Singh A |
Progress in molecular biology and translational science | 2016 |
PCSK1 Variants and Human Obesity.
Ramos-Molina B, Martin MG, Lindberg I |
Progress in molecular biology and translational science | 2016 |
Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go
R Buchsbaum, S Oh |
Cancers | 2016 |
Serum uPAR as Biomarker in Breast Cancer Recurrence: A Mathematical Model
W Hao, A Friedman, YH Hsieh |
PloS one | 2016 |
Epithelial Plasticity During Human Breast Morphogenesis and Cancer Progression
S Ingthorsson, E Briem, JT Bergthorsson, T Gudjonsson |
Journal of Mammary Gland Biology and Neoplasia | 2016 |
Pancreatic cancer stromal biology and therapy
D Xie, K Xie |
Genes & Diseases | 2015 |
Mesenchymal–epithelial interactions during digestive tract development and epithelial stem cell regeneration
LL Guen, S Marchal, S Faure, PS Barbara |
Cellular and Molecular Life Sciences | 2015 |
Local adipocyte cancer cell paracrine loop: can “sick fat” be more detrimental?
MC Rio, N Dali-Youcef, C Tomasetto |
Hormone Molecular Biology and Clinical Investigation | 2015 |
Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences
K Richter, A Konzack, T Pihlajaniemi, R Heljasvaara, T Kietzmann |
Redox Biology | 2015 |
P-Selectin Sustains Extramedullary Hematopoiesis in the G ata1 low Model of Myelofibrosis: Spleen-Specific Myelofibrosis Stem Cell Niches
GJ Spangrude, D Lewandowski, F Martelli, M Marra, M Zingariello, L Sancillo, RA Rana, AR Migliaccio |
Stem Cells | 2015 |
Matrix Rigidity Mediates TGFβ1-induced Epithelial-Myofibroblast Transition by Controlling Cytoskeletal Organization and MRTF-A Localization: MATRIX RIGIDITY MEDIATES EMT VIA MRTF-A
JW O'Connor, PN Riley, SM Nalluri, PK Ashar, EW Gomez |
Journal of Cellular Physiology | 2015 |
Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma: PDPN-CAFs lead and enhance cancer cell invasion
S Neri, G Ishii, H Hashimoto, T Kuwata, K Nagai, H Date, A Ochiai |
International Journal of Cancer | 2015 |
Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
D Zhang, Y Wang, Z Shi, J Liu, P Sun, X Hou, J Zhang, S Zhao, BP Zhou, J Mi |
Cell Reports | 2015 |
Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation
M Choudhary, C Naczki, W Chen, KD Barlow, LD Case, LJ Metheny-Barlow |
BMC Cancer | 2015 |
Bone marrow-derived stromal cells are associated with gastric cancer progression
H Kasashima, M Yashiro, H Nakamae, G Masuda, H Kinoshita, T Morisaki, T Fukuoka, T Hasegawa, K Sakurai, T Toyokawa, N Kubo, H Tanaka, K Muguruma, M Ohira, T Nakane, M Hino, K Hirakawa |
British Journal of Cancer | 2015 |
Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment
G Ishii, A Ochiai, S Neri |
Advanced Drug Delivery Reviews | 2015 |
In vitro three-dimensional models in cancer research: a review
G Imparato, F Urciuolo, PA Netti |
International Materials Reviews | 2015 |
Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer
JW O'Connor, EW Gomez |
Clinical and Translational Medicine | 2014 |
Cellular Mechanisms of Tissue Fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis
CE Barkauskas, PW Noble |
American journal of physiology. Cell physiology | 2014 |
MFG-E8 Regulates Angiogenesis in Cutaneous Wound Healing
A Uchiyama, K Yamada, S Ogino, Y Yokoyama, Y Takeuchi, MC Udey, O Ishikawa, S Motegi |
The American Journal of Pathology | 2014 |
The Cytokine IL-6 Reactivates Breast Stromal Fibroblasts through Transcription Factor STAT3-dependent Up-regulation of the RNA-binding Protein AUF1
SF Hendrayani, HH Al-Khalaf, A Aboussekhra |
The Journal of biological chemistry | 2014 |
Cancer-associated fibroblasts in digestive tumors
Lei Huang, Lei Huang, A. Man Xu, Sha Liu, Wei Liu, Wei Liu, Tuan Jie Li |
World Journal of Gastroenterology | 2014 |
The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer
B Weigelt, CM Ghajar, MJ Bissell |
Advanced Drug Delivery Reviews | 2014 |
Targeting chemokine pathways in esophageal adenocarcinoma
MS Shrivastava, Z Hussain, O Giricz, N Shenoy, R Polineni, A Maitra, A Verma |
Cell cycle (Georgetown, Tex.) | 2014 |
Targeting cardiac fibroblasts to treat fibrosis of the heart: Focus on HDACs
KB Schuetze, TA McKinsey, CS Long |
Journal of Molecular and Cellular Cardiology | 2014 |
Myofibroblasts in oral lesions: A review
S Pinisetti, R Manyam, B Suresh, V Aparna |
Journal of Oral and Maxillofacial Pathology : JOMFP | 2014 |
Role of CXCL12 and CXCR4 in normal cerebellar development and medulloblastoma: CXCL12 and CXCR4 in cerebellar development and MB
PM Ozawa, CB Ariza, CM Ishibashi, TC Fujita, BK Banin-Hirata, JM Oda, MA Watanabe |
International Journal of Cancer | 2014 |
Low-grade myofibroblastic sarcomas of the maxilla
JY Qiu, P Liu, C Shi, B Han |
Oncology Letters | 2014 |
Automated quantification of aligned collagen for human breast carcinoma prognosis
KW Eliceiri, MW Conklin, JS Bredfeldt, TR Mackie, Y Liu, PJ Keely |
Journal of Pathology Informatics | 2014 |
Importance of stroma in breast cancer
AL Reddy, K Polireddy |
The Journal of Clinical and Scientific Research | 2014 |
Cancer-associated fibroblasts in digestive tumors
L Huang, AM Xu, S Liu, W Liu, TJ Li |
World journal of gastroenterology : WJG | 2014 |
Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer
JW OConnor, EW Gomez |
Clinical and Translational Medicine | 2014 |
Origin and function of myofibroblasts in kidney fibrosis
VS LeBleu, G Taduri, J O'Connell, Y Teng, VG Cooke, C Woda, H Sugimoto, R Kalluri |
Nature Medicine | 2013 |
Triggering the landslide: The tumor-promotional effects of myofibroblasts
C Mehner, DC Radisky |
Experimental Cell Research | 2013 |
Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor-associated fibroblasts in preclinical models
SE Wheeler, H Shi, F Lin, S Dasari, J Bednash, S Thorne, S Watkins, R Joshi, SM Thomas |
Head & Neck | 2013 |
Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel
S Zhang, I Mercado-Uribe, J Liu |
International Journal of Cancer | 2013 |
The correlation of hematopoietic stem cells with cancer stem cells through the regulation of stromal cells in tumor microenvironment
S Lin, S Fu |
Medical Hypotheses | 2013 |
Separation and cultivation of laryngeal carcinoma-associated fibroblasts and biological influence on a laryngeal carcinoma cell line
H Du, CP Wu, L Zhou, J Tian |
Acta Oto-laryngologica | 2013 |
An assessment of mast cells and myofibroblasts in denture-induced fibrous hyperplasia
M Kiuchi, T Yamamura, M Okudera, V Souksavanh, T Ishigami, T Iwase, S Warnakulasuriya, K Komiyama |
Journal of Oral Pathology & Medicine | 2013 |
Genetic regulation and potentially therapeutic application of cancer-associated fibroblasts in oral cancer
J Wang, A Min, S Gao, Z Tang |
Journal of Oral Pathology & Medicine | 2013 |
Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin
N Bakhtyar, N Wong, A Kapoor, JC Cutz, B Hill, M Ghert, D Tang |
European Journal of Cancer | 2013 |
Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis
M Zeisberg, R Kalluri |
American journal of physiology. Cell physiology | 2013 |
Targeted destruction of the orchestration of the pancreatic stroma and tumor cells in pancreatic cancer cases: Molecular basis for therapeutic implications
X Kong, L Li, Z Li, K Xie |
Cytokine & Growth Factor Reviews | 2012 |
Expression of the E-cadherin repressors Snail, Slug and Zeb1 in urothelial carcinoma of the urinary bladder: relation to stromal fibroblast activation and invasive behaviour of carcinoma cells
J Schulte, M Weidig, P Balzer, P Richter, M Franz, K Junker, M Gajda, K Friedrich, H Wunderlich, A Östman, I Petersen, A Berndt |
Histochemistry and Cell Biology | 2012 |
Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis
M Zeisberg, R Kalluri |
American journal of physiology. Cell physiology | 2012 |
Tumor stroma as targets for cancer therapy
J Zhang, J Liu |
Pharmacology & Therapeutics | 2012 |
The impact of adhesion peptides within hydrogels on the phenotype and signaling of normal and cancerous mammary epithelial cells
MS Weiss, BP Bernabé, A Shikanov, DA Bluver, MD Mui, S Shin, LJ Broadbelt, LD Shea |
Biomaterials | 2012 |
The reactive stroma microenvironment and prostate cancer progression
DA Barron, DR Rowley |
Endocrine Related Cancer | 2012 |
Stromal biomarkers in breast cancer development and progression
JA Rudnick, C Kuperwasser |
Clinical & Experimental Metastasis | 2012 |
Overexpression of thrombospondin-1 in stromal myofibroblasts is associated with tumor growth and nodal metastasis in gastric carcinoma
XD Lin, SQ Chen, YL Qi, JW Zhu, Y Tang, JY Lin |
Journal of Surgical Oncology | 2012 |
Expression of Caveolin-1, Caveolin-2 and Caveolin-3 in Thyroid Cancer and Stroma
D Kim, H Kim, JS Koo |
Pathobiology | 2012 |
The prognostic value of tumour-stroma ratio in triple-negative breast cancer
AM Moorman, R Vink, HJ Heijmans, J der Palen, EA Kouwenhoven |
European Journal of Surgical Oncology (EJSO) | 2012 |
Transcription Factor Networks in Invasion-Promoting Breast Carcinoma-Associated Fibroblasts
A Siletz, E Kniazeva, JS Jeruss, LD Shea |
Cancer Microenvironment | 2012 |
Cytometric and biochemical characterization of human breast cancer cells reveals heterogeneous myoepithelial phenotypes
F Leccia, A Nardone, S Corvigno, LD Vecchio, SD Placido, F Salvatore, BM Veneziani |
Cytometry Part A | 2012 |
Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes
CA Fordyce, KT Patten, TB Fessenden, R Defilippis, ES Hwang, J Zhao, TD Tlsty |
Breast Cancer Research | 2012 |
Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts
LJ Hawinkels, M Paauwe, HW Verspaget, E Wiercinska, JM van der Zon, K der Ploeg, PJ Koelink, JH Lindeman, W Mesker, P Dijke, CF Sier |
Oncogene | 2012 |
Cancer: Tumor Iron Metabolism, Mitochondrial Dysfunction and Tumor Immunosuppression; “A Tight Partnership—Was Warburg Correct?”
RL Elliott, JF Head |
Journal of Cancer Therapy | 2012 |
Differential Mechanical Response of Mesenchymal Stem Cells and Fibroblasts to Tumor-Secreted Soluble Factors
DJ McGrail, D Ghosh, ND Quach, MR Dawson, L Kreplak |
PloS one | 2012 |
Role of myocyte enhancing factor 2B in epithelial myofibroblast transition of human gingival keratinocytes
Q Sun, A Sattayakhom, J Backs, W Stremmel, W Chamulitrat |
Experimental biology and medicine (Maywood, N.J.) | 2012 |
The origin of interstitial myofibroblasts in chronic kidney disease
I Grgic, JS Duffield, BD Humphreys |
Pediatric Nephrology | 2011 |
Effects of the Histone Deacetylase Inhibitor Valproic Acid on Human Pericytes In Vitro
J Karén, A Rodriguez, T Friman, L Dencker, C Sundberg, B Scholz, JM Gimble |
PloS one | 2011 |
Modeling Colon Adenocarcinomas in Vitro
H Dolznig, C Rupp, C Puri, C Haslinger, N Schweifer, E Wieser, D Kerjaschki, P Garin-Chesa |
The American Journal of Pathology | 2011 |
Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells
JA Rudnick, LM Arendt, I Klebba, JW Hinds, V Iyer, PB Gupta, SP Naber, C Kuperwasser |
PloS one | 2011 |
Investigating monogenic and complex diseases with pluripotent stem cells
H Zhu, MW Lensch, P Cahan, GQ Daley |
Nature Reviews Genetics | 2011 |
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
MJ Bissell, WC Hines |
Nature Medicine | 2011 |
Tissue remodelling in breast cancer: human mast cell tryptase as an initiator of myofibroblast differentiation
A Mangia, A Malfettone, R Rossi, A Paradiso, G Ranieri, G Simone, L Resta |
Histopathology | 2011 |
Organotypic spheroid cultures to study tumor–stroma interaction during cancer development
H Dolznig, A Walzl, N Kramer, M Rosner, P Garin-Chesa, M Hengstschläger |
Drug Discovery Today: Disease Models | 2011 |
Mesenchymal stromal cell ‘licensing’: a multistep process
M Krampera |
Leukemia | 2011 |
Airway remodeling in asthma: New mechanisms and potential for pharmacological intervention
PO Girodet, A Ozier, I Bara, JM de Lara, R Marthan, P Berger |
Pharmacology & Therapeutics | 2011 |
Efficacy Assessment of Interferon-Alpha–Engineered Mesenchymal Stromal Cells in a Mouse Plasmacytoma Model
S Sartoris, M Mazzocco, M Tinelli, M Martini, F Mosna, V Lisi, S Indraccolo, L Moserle, T Cestari, AP Riviera, F Bifari, G Tridente, G Pizzolo, M Krampera |
Stem Cells and Development | 2011 |
Label-Free Characterization of Cancer-Activated Fibroblasts Using Infrared Spectroscopic Imaging
SE Holton, MJ Walsh, A Kajdacsy-Balla, R Bhargava |
Biophysical Journal | 2011 |
„Tumor microenvironment“ in gastrointestinalen Tumoren
B Etschmann, S Gattenlöhner |
Der Pathologe | 2011 |
Advances in Cancer Research
M Lemaire, S Deleu, ED Bruyne, EV Valckenborgh, E Menu, K Vanderkerken |
Advances in Cancer Research Volume 110 | 2011 |
An Immunohistochemical Method to Study Breast Cancer Cell Subpopulations and Their Growth Regulation by Hormones in Three-Dimensional Cultures
MP Pinto, BM Jacobsen, KB Horwitz |
Frontiers in Endocrinology | 2011 |
Myofibroblast persistence and collagen type I accumulation in the human stenotic trachea
JG Reis, CM Takiya, AL Carvalho, RS Mota, B De-Ary-Pires, MA Pires-Neto, R Ary-Pires |
Head & Neck | 2011 |
Transcriptome Analysis of Epithelial and Stromal Contributions to Mammogenesis in Three Week Prepartum Cows
T Casey, H Dover, J Liesman, L DeVries, M Kiupel, M Vandehaar, K Plaut |
PloS one | 2011 |
In vitro three-dimensional (3D) models in cancer research: An update
LC Kimlin, G Casagrande, VM Virador |
Molecular Carcinogenesis | 2011 |
Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening
J Alcaraz, H Mori, CM Ghajar, D Brownfield, R Galgoczy, MJ Bissell |
Integrative biology : quantitative biosciences from nano to macro | 2011 |
Subcellular localization of early biochemical transformations in cancer-activated fibroblasts using infrared spectroscopic imaging
SE Holton, MJ Walsh, R Bhargava |
The Analyst | 2011 |
Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells
JA Rudnick, LM Arendt, I Klebba, JW Hinds, V Iyer, PB Gupta, SP Naber, C Kuperwasser, T Shioda |
PloS one | 2011 |
Tumor-Associated Fibroblasts and their Matrix
MM Mueller, NE Fusenig |
2011 | |
CXCL12/CXCR4/CXCR7 Chemokine Axis and Cancer Progression
X Sun, G Cheng, M Hao, J Zheng, X Zhou, J Zhang, RS Taichman, KJ Pienta, J Wang |
Cancer metastasis reviews | 2010 |
Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas
EP Kopantzev, NA Vayshlya, MR Kopantseva, VI Egorov, M Pikunov, MV Zinovyeva, TV Vinogradova, IB Zborovskaya, ED Sverdlov |
British Journal of Cancer | 2010 |
Proliferation of myofibroblasts in the stroma of renal oncocytoma: Myofibroblasts and renal oncocytoma
TH Yen, Y Chen, JF Fu, CH Weng, YC Tian, CC Hung, JL Lin, CW Yang |
Cell Proliferation | 2010 |
A Digest on the Role of the Tumor Microenvironment in Gastrointestinal Cancers
M Augsten, C Hägglöf, C Peña, A Ostman |
Cancer Microenvironment | 2010 |
Epithelial-Stromal Interaction 1 (EPSTI1) Substitutes for Peritumoral Fibroblasts in the Tumor Microenvironment
M Neergaard, J Kim, R Villadsen, AJ Fridriksdottir, F Rank, V Timmermans-Wielenga, A Langerød, AL Børresen-Dale, OW Petersen, L Rønnov-Jessen |
The American Journal of Pathology | 2010 |
Stromal Fibroblasts in Digestive Cancer
DL Worthley, AS Giraud, TC Wang |
Cancer Microenvironment | 2010 |
Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells
JM Poczobutt, J Tentler, X Lu, PJ Schedin, A Gutierrez-Hartmann |
BMC Cancer | 2010 |
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
M Shimoda, KT Mellody, A Orimo |
Seminars in Cell & Developmental Biology | 2010 |
Long-term cultures of stem/progenitor cells from lobular and ductal breast carcinomas under non-adherent conditions
A Nardone, S Corvigno, A Brescia, D D'Andrea, G Limite, BM Veneziani |
Cytotechnology | 2010 |
Stroma in breast development and disease
LM Arendt, JA Rudnick, PJ Keller, C Kuperwasser |
Seminars in Cell & Developmental Biology | 2010 |
Oxidative stress promotes myofibroblast differentiation and tumour spreading
A Toullec, D Gerald, G Despouy, B Bourachot, M Cardon, S Lefort, M Richardson, G Rigaill, MC Parrini, C Lucchesi, D Bellanger, MH Stern, T Dubois, X Sastre-Garau, O Delattre, A Vincent-Salomon, F Mechta-Grigoriou |
EMBO Molecular Medicine | 2010 |
Fibrogenic Reactions in Lung Disease
J Araya, SL Nishimura |
Annual Review of Pathology: Mechanisms of Disease | 2010 |
Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer
ES Radisky, DC Radisky |
Journal of Mammary Gland Biology and Neoplasia | 2010 |
Biofunctionalization of electrospun PCL-based scaffolds with perlecan domain IV peptide to create a 3-D pharmacokinetic cancer model
O Hartman, C Zhang, EL Adams, MC Farach-Carson, NJ Petrelli, BD Chase, JF Rabolt |
Biomaterials | 2010 |
Tissue-Engineered Three-Dimensional Tumor Models to Study Tumor Angiogenesis
SS Verbridge, EM Chandler, C Fischbach |
Tissue Engineering Part A | 2010 |
Tumor Engineering: The Other Face of Tissue Engineering
CM Ghajar, MJ Bissell |
Tissue Engineering Part A | 2010 |
Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly similar to their bone marrow counterparts
JC Brune, A Tormin, MC Johansson, P Rissler, O Brosjö, R Löfvenberg, FV von Steyern, F Mertens, A Rydholm, S Scheding |
International Journal of Cancer | 2010 |
Stroma : partenaire actif mais sous-estiméde la tumorigenèse, « quand le dialogue remplace le monologue »
PM Martin, C Dussert, LH Ouafik |
Oncologie | 2010 |
Determinants of leader cells in collective cell migration
AA Khalil, P Friedl |
Integrative Biology | 2010 |
Intensity of stromal changes predicts biochemical recurrence-free survival in prostatic carcinoma
D Tomas, B Spajić, M Milošević, A Demirović, Z Marušić, B Krušlin |
Scandinavian Journal of Urology and Nephrology | 2010 |
Myofibroblasts are associated with the progression of scirrhous gastric carcinoma
Y Fuyuhiro, M Yashiro, S Noda, S Kashiwagi, J Matsuoka, Y Doi, Y Kato, K Muguruma, T Sawada, K Hirakawa |
Experimental and therapeutic medicine | 2010 |
Endothelial cells stimulate growth of normal and cancerous breast epithelial cells in 3D culture
S Ingthorsson, V Sigurdsson, , JG Jonasson, J Kjartansson, MK Magnusson, T Gudjonsson |
BMC Research Notes | 2010 |
Tissue-resident stem cells promote breast cancer growth and metastasis
FL Muehlberg, YH Song, A Krohn, SP Pinilla, LH Droll, X Leng, M Seidensticker, J Ricke, AM Altman, E Devarajan, W Liu, RB Arlinghaus, EU Alt |
Carcinogenesis | 2009 |
Transformed epithelial cells and fibroblasts/myofibroblasts interaction in breast tumor: a mathematical model and experiments
Y Kim, J Wallace, F Li, M Ostrowski, A Friedman |
Journal of Mathematical Biology | 2009 |
Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma
M Franz, K Spiegel, C Umbreit, P Richter, C Codina-Canet, A Berndt, A Altendorf-Hofmann, S Koscielny, P Hyckel, H Kosmehl, I Virtanen, A Berndt |
Histochemistry and Cell Biology | 2009 |
Revisiting the seed and soil in cancer metastasis
M Mendoza, C Khanna |
The International Journal of Biochemistry & Cell Biology | 2009 |
Breast cancer by proxy: can the microenvironment be both the cause and consequence?
L Rønnov-Jessen, MJ Bissell |
Trends in Molecular Medicine | 2009 |
Interaction of Tumor with Its Micro-environment: A Mathematical Model
Y Kim, A Friedman |
Bulletin of Mathematical Biology | 2009 |
Active TGF-β1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence
LJ Hawinkels, HW Verspaget, JJ van der Reijden, JM van der Zon, JH Verheijen, DW Hommes, CB Lamers, CF Sier |
Cancer Science | 2009 |
Scleroderma
A Gabrielli, EV Avvedimento, T Krieg |
New England Journal of Medicine | 2009 |
Muscularis mucosae in desmoplastic stroma formation of early invasive rectal adenocarcinoma
S Ban, M Shimizu |
World journal of gastroenterology : WJG | 2009 |
The Biology of Gastric Cancers
TC Wang, JG Fox, AS Giraud |
2009 | |
Lung Cancer Metastasis
V Keshamouni, D Arenberg, G Kalemkerian |
2009 | |
Active TGF‐β1 correlates with myofibroblasts and malignancy in the colorectal adenoma‐carcinoma sequence
Hawinkels LJ, Verspaget HW, Van Der Reijden JJ, Van Der Zon JM, Verheijen JH, Hommes DW, Lamers CB, Sier CF |
Cancer Science | 2009 |
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer
B Weigelt, MJ Bissell |
Seminars in Cancer Biology | 2008 |
The Molecular Basis of Cancer
A Bafico, L Grumolato, SA Aaronson |
The Molecular Basis of Cancer | 2008 |
B-1 lymphocytes increase metastatic behavior of melanoma cells through the extracellular signal-regulated kinase pathway
EC Pérez, J Machado, F Aliperti, E Freymüller, M Mariano, JD Lopes |
Cancer Science | 2008 |
Nonlinear Optical Imaging of Cellular Processes in Breast Cancer
PP Provenzano, KW Eliceiri, L Yan, A Ada-Nguema, MW Conklin, DR Inman, PJ Keely |
Microscopy and Microanalysis | 2008 |
Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle
ER Motrescu, MC Rio |
Biological Chemistry | 2008 |
Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer
PP Provenzano, CT Rueden, SM Trier, L Yan, SM Ponik, DR Inman, PJ Keely, KW Eliceiri |
Journal of Biomedical Optics | 2008 |
The myofibroblast in health and disease
B Eyden |
Revista Española de Patología | 2008 |
Integrin alpha1beta1 is involved in the differentiation into myofibroblasts in adult reactive tissues in vivo
A Rodriguez, J Karen, H Gardner, B Gerdin, K Rubin, C Sundberg |
Journal of Cellular and Molecular Medicine | 2008 |
Stromal Fibroblasts Activated by Tumor Cells Promote Angiogenesis in Mouse Gastric Cancer
X Guo, H Oshima, T Kitmura, MM Taketo, M Oshima |
The Journal of biological chemistry | 2008 |
Transforming Growth Factor-β in Cancer Therapy, Volume II
SB Jakowlew |
2008 | |
Bone Marrow-Derived Progenitors
K Kauser, AM Zeiher |
2007 | |
Role of chemokines in tumor growth
D Raman, PJ Baugher, YM Thu, A Richmond |
Cancer Letters | 2007 |
Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?
DC Radisky, PA Kenny, MJ Bissell |
Journal of Cellular Biochemistry | 2007 |
Translational Medicine: The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine
B Eyden |
Journal of Cellular and Molecular Medicine | 2007 |
Desmoplasia in Different Degrees of Invasion of Carcinoma Ex-Pleomorphic Adenoma
VC de Araújo, C Furuse, PR Cury, A Altemani, VA Alves, NS de Araújo |
Head and Neck Pathology | 2007 |
Stromal induction of breast cancer: Inflammation and invasion
ES Radisky, DC Radisky |
Reviews in Endocrine and Metabolic Disorders | 2007 |
Secretion of Cytokines in Breast Cancer Cells: The Molecular Mechanism of Procathepsin D Proliferative Effects
M Fusek, J Vetvickova, V Vetvicka |
Journal of Interferon & Cytokine Research | 2007 |
Presence of Human Circulating Progenitor Cells for Cancer Stromal Fibroblasts in the Blood of Lung Cancer Patients
G Ishii, TK Ito, K Aoyagi, H Fujimoto, H Chiba, T Hasebe, S Fujii, K Nagai, H Sasaki, A Ochiai |
Stem Cells | 2007 |
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
C Gaggioli, S Hooper, C Hidalgo-Carcedo, R Grosse, JF Marshall, K Harrington, E Sahai |
Nature Cell Biology | 2007 |
Paradoxical antiproliferative effect by a murine mammary tumor-derived epithelial cell line
EN Gurzov, SM Nabha, H Yamamoto, H Meng, OG Scharovsky, RD Bonfil |
BMC Cancer | 2007 |
Mesenchymal Stem Cells in Cancer: Tumor-Associated Fibroblasts and Cell-Based Delivery Vehicles
B Hall, J Dembinski, A Sasser, M Studeny, M Andreeff, F Marini |
International Journal of Hematology | 2007 |
Leading the charge
DC Radisky |
Nature Cell Biology | 2007 |
Cancer du sein avancé
D Serin, G de Rauglaudre |
2007 | |
Cytokines in the Genesis and Treatment of Cancer
MA Caligiuri, MT Lotze |
2007 | |
Review of the Pericyte during Angiogenesis and its Role in Cancer and Diabetic Retinopathy
AP Hall |
Toxicologic pathology | 2006 |
Encyclopedia of Molecular Cell Biology and Molecular Medicine
E Beutler |
Encyclopedia of Molecular Cell Biology and Molecular Medicine | 2006 |
Modulation of response to tumor therapies by the extracellular matrix
CL Addison |
Future Oncology | 2006 |
Differential expression of insulin-like growth factor binding protein-5 in pancreatic adenocarcinomas: Identification using DNA microarray
SK Johnson, RA Dennis, GW Barone, LW Lamps, RS Haun |
Molecular Carcinogenesis | 2006 |
TUMOR STROMA AND REGULATION OF CANCER DEVELOPMENT
TD Tlsty, LM Coussens |
Annual Review of Pathology: Mechanisms of Disease | 2006 |
Evolution of cooperation among tumor cells
R Axelrod, DE Axelrod, KJ Pienta |
Proceedings of the National Academy of Sciences | 2006 |
Collagen reorganization at the tumor-stromal interface facilitates local invasion
PP Provenzano, KW Eliceiri, JM Campbell, DR Inman, JG White, PJ Keely |
BMC Medicine | 2006 |
FAK-dependent regulation of myofibroblast differentiation
RS Greenberg, AM Bernstein, M Benezra, IH Gelman, L Taliana, SK Masur |
The FASEB Journal | 2006 |
Tissue Repair, Contraction and the Myofibroblast
C Chaponnier, A Desmoulière, G Gabbiani |
2006 | |
Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks
N Cheng, NA Bhowmick, A Chytil, AE Gorksa, KA Brown, R Muraoka, CL Arteaga, EG Neilson, SW Hayward, HL Moses |
Oncogene | 2005 |
Radiation and the microenvironment – tumorigenesis and therapy
MH Barcellos-Hoff, C Park, EG Wright |
Nature Reviews Cancer | 2005 |
Multifunctionality of PAI-1 in fibrogenesis: Evidence from obstructive nephropathy in PAI-1-overexpressing mice1
S Matsuo, JM Lopez-Guisa, X Cai, DM Okamura, CE Alpers, RE Bumgarner, MA Peters, G Zhang, AA Eddy |
Kidney International | 2005 |
Do Myoepithelial Cells Hold the Key for Breast Tumor Progression?
K Polyak, M Hu |
Journal of Mammary Gland Biology and Neoplasia | 2005 |
The Fibroblastic Coconspirator in Cancer Progression
M Egeblad, LE Littlepage, Z Werb |
Cold Spring Harbor Symposia on Quantitative Biology | 2005 |
Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation
CM Nelson, MJ Bissell |
Seminars in Cancer Biology | 2005 |
From a unique cell to metastasis is a long way to go: clues to stromelysin-3 participation
MC Rio |
Biochimie | 2005 |
Isolated crypts form spheres prior to full intestinal differentiation when grown as xenografts: anin vivo model for the study of intestinal differentiation and crypt neogenesis, and for the abnormal crypt architecture of juvenile polyposis coli
RD Buono, CY Lee, CJ Hawkey, NA Wright |
The Journal of Pathology | 2005 |
Tumour-Stromal Interactions in Breast Cancer: The Role of Stroma in Tumourigenesis
JB Kim, R Stein, MJ O’Hare |
Tumor Biology | 2005 |
Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy
P Micke, A Östman |
Expert Opinion on Therapeutic Targets | 2005 |
Three-dimensional tissue culture models in cancer biology
JB Kim |
Seminars in Cancer Biology | 2005 |
In Vivo Characterization of Bone Marrow-Derived Fibroblasts Recruited into Fibrotic Lesions
G Ishii, T Sangai, K Sugiyama, T Ito, T Hasebe, Y Endoh, J Magae, A Ochiai |
Stem Cells | 2005 |
Clonogenic growth of human breast cancer cells co-cultured in direct contact with serum-activated fibroblasts
M Samoszuk, J Tan, G Chorn |
Breast Cancer Research | 2005 |
The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts
M Samoszuk, J Tan, G Chorn |
BMC complementary and alternative medicine | 2005 |
Conceptual and Practical Implications of Breast Tissue Geometry: Toward a More Effective, Less Toxic Therapy
L Norton |
The oncologist | 2005 |
Rise and Fall of Epithelial Phenotype
P Savagner |
2005 | |
Stromal fibroblasts in cancer initiation and progression
NA Bhowmick, EG Neilson, HL Moses |
Nature | 2004 |
A Visual-Quantitative Analysis of Fibroblastic Stromagenesis in Breast Cancer Progression
E Cukierman |
Journal of Mammary Gland Biology and Neoplasia | 2004 |
Homeostasis in the breast
A Rizki, MJ Bissell |
Cancer Cell | 2004 |
Modulation of prostate cancer growth in bone microenvironments
M Edlund, SY Sung, LW Chung |
Journal of Cellular Biochemistry | 2004 |
The potential value of (Myo)fibroblastic stromal reaction in the diagnosis of prostatic adenocarcinoma
D Tomas, B Kru?lin |
The Prostate | 2004 |
Three-dimensional in vitro tissue culture models of breast cancer — a review
JB Kim, R Stein, MJ O'Hare |
Breast Cancer Research and Treatment | 2004 |
Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
P Micke, A tman |
Lung Cancer | 2004 |
Molecular characterization of the tumor microenvironment in breast cancer
M Allinen, R Beroukhim, L Cai, C Brennan, J Lahti-Domenici, H Huang, D Porter, M Hu, L Chin, A Richardson, S Schnitt, WR Sellers, K Polyak |
Cancer Cell | 2004 |
Induction of Vascular Smooth Muscle α-Actin Gene Transcription in Transforming Growth Factor β1-Activated Myofibroblasts Mediated by Dynamic Interplay between the Pur Repressor Proteins and Sp1/Smad Coactivators
SV Subramanian, JA Polikandriotis, RJ Kelm, JJ David, CG Orosz, AR Strauch |
Molecular biology of the cell | 2004 |
Induction of Syndecan-1 Expression in Stromal Fibroblasts Promotes Proliferation of Human Breast Cancer Cells
T Maeda, CM Alexander, A Friedl |
Cancer research | 2004 |
Epithelial to Mesenchymal Transition in Human Breast Cancer Can Provide a Nonmalignant Stroma
OW Petersen, HL Nielsen, T Gudjonsson, R Villadsen, F Rank, E Niebuhr, MJ Bissell, L Rønnov-Jessen |
The American Journal of Pathology | 2003 |
Role of tissue stroma in cancer cell invasion
OD Wever, M Mareel |
The Journal of Pathology | 2003 |
To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia
T Gudjonsson, L Rønnov-Jessen, R Villadsen, MJ Bissell, OW Petersen |
Methods | 2003 |
The Myofibroblast Is the Predominant Plasminogen Activator Inhibitor-1-Expressing Cell Type in Human Breast Carcinomas
BV Offersen, BS Nielsen, G Høyer-Hansen, F Rank, S Hamilton-Dutoit, J Overgaard, PA Andreasen |
The American Journal of Pathology | 2003 |
Lung Biology in Health and Disease
N Zamel |
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential | 2003 |
Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction
G Ishii, T Sangai, T Oda, Y Aoyagi, T Hasebe, N Kanomata, Y Endoh, C Okumura, Y Okuhara, J Magae, M Emura, T Ochiya, A Ochiai |
Biochemical and Biophysical Research Communications | 2003 |
Central role for Rho in TGF-β 1 -induced α-smooth muscle actin expression during epithelial-mesenchymal transition
A Masszi, CD Ciano, G Sirokmány, WT Arthur, OD Rotstein, J Wang, CA McCulloch, L Rosivall, I Mucsi, A Kapus |
American journal of physiology. Renal physiology | 2003 |
Immunohistochemical Study of Myofibroblasts in Colorectal Epithelial Lesions
S Ban, T Mitsuhashi, M Shimizu |
Archives of pathology & laboratory medicine | 2003 |
Human fibroblasts from normal and malignant breast tissue grown in vitro show a distinct senescence profile and telomerase activity
Maria Teresa Valenti, Saverio Sartore, Giuseppe Azzarello, Elena Balducci, Marina Amadio, Marco Sandri, Giovanni Luigi Pappagallo, Giovanni Tacchetti, Mario Bari, Riccardo Manconi, Mario Rosario D'Andrea, Barbara Silvestri, Orazio Vinante |
The Histochemical Journal | 2003 |
To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia.
Gudjonsson T, Rønnov-Jessen L, Villadsen R, Bissell MJ, Petersen OW |
Methods (San Diego, Calif.) | 2003 |
The organizing principle: microenvironmental influences in the normal and malignant breast
MJ Bissell, DC Radisky, A Rizki, VM Weaver, OW Petersen |
Differentiation | 2002 |
Identification of EPSTI1, a Novel Gene Induced by Epithelial–Stromal Interaction in Human Breast Cancer
HL Nielsen, L Rønnov-Jessen, R Villadsen, OW Petersen |
Genomics | 2002 |
Differential Expression of a Chloride Intracellular Channel Gene, CLIC4, in Transforming Growth Factor-β1-Mediated Conversion of Fibroblasts to Myofibroblasts
L Rønnov-Jessen, R Villadsen, JC Edwards, OW Petersen |
The American Journal of Pathology | 2002 |
Prostate tumor-stroma interaction: molecular mechanisms and opportunities for therapeutic targeting
SY Sung, LW Chung |
Differentiation | 2002 |
Role of Myofibroblasts at the Invasion Front
OD Wever, M Mareel |
Biological Chemistry | 2002 |
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties
T Gudjonsson, R Villadsen, HL Nielsen, L Rønnov-Jessen, MJ Bissell, OW Petersen |
Genes & development | 2002 |
Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts
L Rønnov-Jessen, R Villadsen, JC Edwards, OW Petersen |
The American Journal of Pathology | 2002 |
Pan Vascular Medicine
P Lanzer, EJ Topol |
2002 | |
Conditioned medium from MCF-7 cell line induces myofibroblast differentiation, decreased cell proliferation, and increased apoptosis in cultured normal fibroblasts but not in fibroblasts from malignant breast tissue
M T Valenti, G Azzarello, E Balducci, S Sartore, M Sandri, R Manconi, U Sicari, M Bari, O Vinante |
The Histochemical Journal | 2002 |
PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction
T Oda, YO Jung, HS Kim, X Cai, JM López-Guisa, Y Ikeda, AA Eddy |
Kidney International | 2001 |
Putting tumours in context
MJ Bissell, D Radisky |
Nature reviews. Cancer | 2001 |
Differential Expression of Protease-Activated Receptors-1 and -2 in Stromal Fibroblasts of Normal, Benign, and Malignant Human Tissues
MR D'Andrea, CK Derian, RJ Santulli, P Andrade-Gordon |
The American Journal of Pathology | 2001 |
REACTIVE STROMA IN PROSTATE CANCER PROGRESSION
JA Tuxhorn, GE Ayala, DR Rowley |
The Journal of Urology | 2001 |
Stromal cells can contribute oncogenic signals
TD Tlsty |
Seminars in Cancer Biology | 2001 |
Renal fibroblast-like cells in Goodpasture syndrome rats
H Okada, T Inoue, Y Kanno, T Kobayashi, S Ban, R Kalluri, H Suzuki |
Kidney International | 2001 |
Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation
MA Chrenek, P Wong, VM Weaver |
Breast Cancer Research | 2001 |
The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion
OW Petersen, HL Nielsen, T Gudjonsson, R Villadsen, L Rønnov-Jessen, MJ Bissell |
Breast Cancer Research | 2001 |
Heart Physiology and Pathophysiology
NS Dhalla, RM Temsah, T Netticadan, MS Sandhu |
Heart Physiology and Pathophysiology | 2001 |
Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation
B Elenbaas, RA Weinberg |
Experimental Cell Research | 2001 |
Lung fibrosis
C Fonseca, D Abraham, CM Black |
Springer Seminars in Immunopathology | 2000 |
Ultrastructure of early phase hepatic metastasis of human colon carcinoma cells with special reference to desmosomal junctions with hepatocytes
S Shimizu, N Yamada, T Sawada, K Ikeda, K Nakatani, S Seki, K Kaneda, K Hirakawa |
Pathology International | 2000 |
The effect of environmental cues on the differentiation of myofibroblasts in peritoneal granulation tissue
JL Efendy, GR Campbell, JH Campbell |
The Journal of Pathology | 2000 |
Myofibroblasts: paracrine cells important in health and disease
DW Powell |
Transactions of the American Clinical and Climatological Association | 2000 |
Principles of Tissue Engineering
AS Xu, AS Xu, TL Luntz, JM Macdonald, JM Macdonald, H Kubota, E Hsu, RE London, LM Reid |
Principles of Tissue Engineering | 2000 |
Transforming Growth Factor-β1 Promotes the Morphological and Functional Differentiation of the Myofibroblast
MB Vaughan, EW Howard, JJ Tomasek |
Experimental Cell Research | 2000 |
In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells
S Shimizu, N Yamada, T Sawada, K Ikeda, N Kawada, S Seki, K Kaneda, K Hirakawa |
Japanese journal of cancer research : Gann | 2000 |
Phenotypic change of muscularis mucosae in early invasive colorectal adenocarcinoma
S Ban |
Journal of clinical pathology | 2000 |
DEVELOPMENT OF MYOFIBROBLASTS FROM HUMAN BONE MARROW MESENCHYMAL STEM CELLS COCULTURED WITH HUMAN COLON CARCINOMA CELLS AND TGF BETA 1
M Emura, A Ochiai, M Horino, W Arndt, K Kamino, S Hirohashi |
In vitro cellular & developmental biology. Animal | 2000 |
In vivo and in vitro Interactions between Human Colon Carcinoma Cells and Hepatic Stellate Cells
Shimizu S, Yamada N, Sawada T, Ikeda K, Kawada N, Seki S, Kaneda K, Hirakawa K |
Japanese journal of cancer research : Gann | 2000 |
Divergence of smooth muscle target and sympathetic pathway cell phenotypes in the orbit of the developing rat
PG Smith, Q Fan, R Zhang |
The Journal of Comparative Neurology | 1999 |
The N-Cadherin/Catenin Complex in Colon Fibroblasts and Myofibroblasts
L Hoorde, K Braet, M Mareel |
Cell Communication and Adhesion | 1999 |
Myofibroblasts. I. Paracrine cells important in health and disease
D Li, SL Friedman |
The American journal of physiology | 1999 |
Identification of Two Amino Acids within the EIIIA (ED-A) Segment of Fibronectin Constituting the Epitope for Two Function-blocking Monoclonal Antibodies
YF Liao, KG Wieder, JM Classen, LV de Water |
The Journal of biological chemistry | 1999 |
Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis
VS Rajkumar, C Sundberg, DJ Abraham, K Rubin, CM Black |
Arthritis & Rheumatism | 1999 |
Smooth Muscle-Specific SM22 Protein Is Expressed in the Adventitial Cells of Balloon-Injured Rabbit Carotid Artery
E Faggin, M Puato, L Zardo, R Franch, C Millino, F Sarinella, P Pauletto, S Sartore, A Chiavegato |
Arteriosclerosis, thrombosis, and vascular biology | 1999 |
Tissue Repair and Fibrosis
A Desmoulière, B Tuchweber |
1999 | |
Differential expression of SM22 isoforms in myofibroblasts and smooth muscle cells from rabbit bladder
A Chiavegato, M Roelofs, R Franch, E Castellucci, F Sarinella, S Sartore |
Journal of Muscle Research and Cell Motility | 1999 |
Paracrine/autocrine regulation of breast cancer by the insulin-like growth factors
AA Rasmussen, KJ Cullen |
Breast Cancer Research and Treatment | 1998 |
H19 Overexpression in Breast Adenocarcinoma Stromal Cells Is Associated with Tumor Values and Steroid Receptor Status but Independent of p53 and Ki-67 Expression
E Adriaenssens, L Dumont, S Lottin, D Bolle, A Leprêtre, A Delobelle, F Bouali, T Dugimont, J Coll, JJ Curgy |
The American Journal of Pathology | 1998 |
Glandular Structure and Gene Expression: Lessons from the Mammary Glanda
MJ Bissell |
Annals of the New York Academy of Sciences | 1998 |
Cellular terrain surrounding sympathetic nerve pathways in the rat orbit: Comparisons of orbital connective tissue and smooth muscle cell phenotypes
PG Smith, Q Fan, R Zhang, JD Warn |
The Journal of Comparative Neurology | 1998 |
Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology
LA Kunz-Schughart, M Kreutz, R Knuechel |
International Journal of Experimental Pathology | 1998 |
Urokinase-type-plasminogen-activator(UPA) production by human breast (myo)fibroblastsin vitro: Influence of transforming growth factor-β1 (TGFβ1) compared with factor(s) released by human epithelial-carcinoma cells
AM Sieuwerts, JG Klijn, SC Henzen-Logmans, I Bouwman, KE van Roozendaal, HA Peters, B Setyono-Han, JA Foekens |
International Journal of Cancer | 1998 |
Human Wound Contraction: Collagen Organization, Fibroblasts, and Myofibroblasts
R Rudolph, G Gabbiani |
Plastic & Reconstructive Surgery | 1998 |
Demonstration of aromatase activity and its regulation in breast tumor and benign breast fibroblasts
RJ Santen, J Martel, M Hoagland, F Naftolin, L Roa, N Harada, L Hafer, R Zaino, R Pauley, S Santner |
Breast Cancer Research and Treatment | 1998 |
Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype
KL Schmeichel, VM Weaver, MJ Bissell |
Journal of Mammary Gland Biology and Neoplasia | 1998 |
Differentiation and cancer in the mammary gland: shedding light on an old dichotomy
OW Petersen, L Rønnov-Jessen, VM Weaver, MJ Bissell |
Advances in cancer research | 1998 |
Adhesion of Hematopoietic Precursors to Human Stroma: Studies Using Normal Marrow Stromal Myofibroblasts and a Stromal Cell Line Transformed by SV40
F Deschaseaux, JP Remy-Martin, A Keating, P Hervé, P Charbord |
Hematology | 1998 |
The role of stroma in breast carcinoma growth in vivo
A Noël, J M Foidart |
Journal of Mammary Gland Biology and Neoplasia | 1998 |
Contribution of Adventitial Myofibroblasts to Vascular Remodeling and Lesion Formation after Experimental Angioplasty in Pig Coronary Arteries
JN Wilcox, GD Cipolla, FH Martin, L Simonet, B Dunn, CE Ross, NA Scott |
Annals of the New York Academy of Sciences | 1997 |
Functional analysis of the lysyl oxidase promoter in myofibroblast-like clones of 3T6 fibroblast
CJ Saux, C Gleyzal, M Raccurt, P Sommer |
Journal of Cellular Biochemistry | 1997 |
Tumor cell and connective tissue cell interactions in human colorectal adenocarcinoma. Transfer of platelet-derived growth factor-AB/BB to stromal cells
C Sundberg, M Branting, B Gerdin, K Rubin |
The American Journal of Pathology | 1997 |
In situ stromal expression of the urokinase/plasmin system correlates with epithelial dysplasia in colorectal adenomas
I Sordat, P Chaubert, P Protiva, L Guillou, L Mazzucchelli, E Saraga, J Benhattar, C Trân-Thang, AL Blum, G Dorta, B Sordat |
The American Journal of Pathology | 1997 |
Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma
S Peyrol, M Raccurt, F Gerard, C Gleyzal, JA Grimaud, P Sommer |
The American Journal of Pathology | 1997 |
Advances in Molecular and Cell Biology
KJ Clemetson |
Advances in Molecular and Cell Biology | 1997 |
Transformation of rat inner medullary fibroblasts to myofibroblasts in vitro
C Grupp, J Lottermoser, DI Cohen, M Begher, HE Franz, GA Müller |
Kidney International | 1997 |
A Three-dimensional Collagen Lattice Induces Protein Kinase C-ζ Activity: Role in α 2 Integrin and Collagenase mRNA Expression
J Xu, RA Clark |
The Journal of Cell Biology | 1997 |
Cell Death in Reproductive Physiology
JL Tilly, JF Strauss, M Tenniswood |
1997 | |
Angiogenesis in brain tumors; pathobiological and clinical aspects
P Wesseling, D J Ruiter, P C Burger |
Journal of Neuro-Oncology | 1997 |
Stromal Reaction to Invasive Cancer: The Cellular Origin of the Myofibroblast and Implications for Tumor Development
L Rønnov-Jessen |
The Breast Journal | 1996 |
Human foetal lung (IMR-90) cells: Myofibroblasts with smooth muscle-like contractile properties
E Ehler, E Babiychuk, A Draeger |
Cell Motility and the Cytoskeleton | 1996 |
A comparative study of cytokine gene transcripts in normal and malignant breast tissue and primary cell cultures derived from the same tissue samples
V Speirs, AR Green, MC White |
International Journal of Cancer | 1996 |
The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay
VM Weaver, MJ Bissell, AH Fischer, OW Peterson |
Biochemistry and Cell Biology | 1996 |
A function for filamentous alpha-smooth muscle actin: retardation of motility in fibroblasts
L Rønnov-Jessen, OW Petersen |
The Journal of Cell Biology | 1996 |
Myofibroblasts differentiate from fibroblasts when plated at low density
SK Masur, HS Dewal, TT Dinh, I Erenburg, S Petridou |
Proceedings of the National Academy of Sciences | 1996 |
The role of the adventitia in the arterial response to angioplasty: The effect of intravascular radiation
JN Wilcox, R Waksman, SB King, NA Scott |
International journal of radiation oncology, biology, physics | 1996 |
Potential role of the adventitia in arteritis and atherosclerosis
JN Wilcox, NA Scott |
International Journal of Cardiology | 1996 |
Role of urokinase plasminogen activator in human breast cancer: Active involvement of stromal fibroblasts
CE Roozendaal, JG Klijn, AM Sieuwerts, SC Henzen-Logmans, JA Foekens |
Fibrinolysis | 1996 |
Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries
NA Scott, GD Cipolla, CE Ross, B Dunn, FH Martin, L Simonet, JN Wilcox |
Circulation | 1996 |
The importance of the microenvironment in breast cancer progression: recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay.
Weaver VM, Fischer AH, Peterson OW, Bissell MJ |
Biochemistry and cell biology = Biochimie et biologie cellulaire | 1996 |
The H19 gene is expressed within both epithelial and stromal components of human invasive adenocarcinomas
T Dugimont, JJ Curgy, N Wernert, A Delobelle, MB Raes, A Joubel, D Stehelin, J Coll |
Biology of the Cell | 1995 |
The role of fibroblasts in tumor behavior
M Grgoire, B Lieubeau |
Cancer and Metastasis Reviews | 1995 |