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Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

A Muir, … , J Krischer, N Maclaren

A Muir, … , J Krischer, N Maclaren

Published February 1, 1995
Citation Information: J Clin Invest. 1995;95(2):628-634. https://doi.org/10.1172/JCI117707.

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Immature Dendritic Cell Therapy Confers Durable Immune Modulation in an Antigen-Dependent and Antigen-Independent Manner in Nonobese Diabetic Mice J Lo, CQ Xia, R Peng, MJ Clare-Salzler	Journal of Immunology Research	2018
Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice J Grönholm, PP Pagni, MN Pham, CB Gibson, PF Macomber, JL Vela, M Herrath, MJ Lenardo	Diabetologia	2017
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Islet autoantigens: structure, function, localization, and regulation P Arvan, M Pietropaolo, D Ostrov, CJ Rhodes	Cold Spring Harbor Perspectives in Medicine	2012
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Immunization with DNA Encoding an Immunodominant Peptide of Insulin Prevents Diabetes in NOD Mice I Urbanek-Ruiz, PJ Ruiz, V Paragas, H Garren, L Steinman, CG Fathman	Clinical Immunology	2001
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Tacrolimus, but not Cyclosporine A, significantly increases expression of ICAM-1 and IFN-? in the NOD mouse G Papaccio, MV Latronico, A Graziano, A Lanza, M Pedull	Journal of Cellular Biochemistry	2001
Antigen-Specific Mediated Suppression of β Cell Autoimmunity by Plasmid DNA Vaccination R Tisch, B Wang, DJ Weaver, B Liu, T Bui, J Arthos, DV Serreze	Journal of immunology (Baltimore, Md. : 1950)	2001
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Dual Overlapping Peptides Recognized by Insulin Peptide B:9–23 T Cell Receptor AV13S3 T Cell Clones of the NOD Mouse N Abiru, D Wegmann, E Kawasaki, P Gottlieb, E Simone, GS Eisenbarth	Journal of Autoimmunity	2000
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Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity T Kunikata, T Tatefuji, H Aga, K Iwaki, M Ikeda, M Kurimoto	European Journal of Pharmacology	2000
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Detection of dendritic cells in the non-obese diabetic (NOD) mouse islet pancreas infiltrate is correlated with Th2-cytokine production G Papaccio, AD Luca, BD Luca, FA Pisanti, S Zarrilli	Journal of Cellular Biochemistry	1999
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T-cell response to proinsulin and insulin in type 1 and pretype 1 diabetes D Dubois-LaForgue, J C Carel, P F Bougnères, J G Guillet, C Boitard	Journal of Clinical Immunology	1999
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Antigen-based T-cell-targeted immunotherapy: recent developments in autoimmunity and allergy C Stemmer, G Guichard	Expert Opinion on Therapeutic Patents	1998
Recombinant Adenovirus Encoding gp100 Modulates Experimental Melanin-Protein Induced Uveitis (EMIU) CC Chan, Y Li, B Sun, Q Li, DM Matteson, DF Shen, RB Nussenblatt, Y Zhai	Journal of Autoimmunity	1998
Protection from Insulin Dependent Diabetes Mellitus Afforded by Insulin Antigens in Incomplete Freund's Adjuvant Depends on Route of Administration P Hutchings, A Cooke	Journal of Autoimmunity	1998
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Administration of IL-4 Prevents Autoimmune Diabetes but Enhances Pancreatic Insulitis in NOD Mice Y Tominaga, M Nagata, H Yasuda, N Okamoto, K Arisawa, H Moriyama, M Miki, K Yokono, M Kasuga	Clinical Immunology and Immunopathology	1998
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Endocrine Autoimmunity and Associated Conditions AP Weetman		1998
Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice DG Karounos, JS Bryson, DA Cohen	Journal of Clinical Investigation	1997
Oral Administration of the Immunodominant B-chain of Insulin Reduces Diabetes in a Co-transfer Model of Diabetes in the NOD Mouse and is Associated with a Switch from Th1 to Th2 Cytokines M Polanski, NS Melican, J Zhang, HL Weiner	Journal of Autoimmunity	1997
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Immunization Therapies in the Prevention of Diabetes VK Ramiya, MS Lan, CH Wasserfall, AL Notkins, NK Maclaren	Journal of Autoimmunity	1997
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Insulin-dependent diabetes mellitus: the hypothesis of molecular mimicry between islet cell antigens and microorganisms NK Maclaren, MA Atkinson	Molecular Medicine Today	1997
T Cell Recognition of Human Pre-Proinsulin Peptides Depends on the Polymorphism at HLA DQ Locus: A Study Using HLA DQ8 and DQ6 Transgenic Mice R Raju, SR Munn, CS David	Human Immunology	1997
Systemic antigen in the treatment of T-cell-mediated autoimmune diseases R Liblau, R Tisch, N Bercovici, HO McDevitt	Immunology Today	1997
Role of T-cell anergy and suppression in susceptibility to IDDM I Bergerot, G Arreaza, M Cameron, H Chou, TL Delovitch	Research in Immunology	1997
Tolerance and Uveitis JF Bach	American Journal of Ophthalmology	1997
Autoimmune Diabetes DV House, WE Winter	Clinics in Laboratory Medicine	1997
COMBINATION THERAPY WITH CYCLOSPORINE AND INTERLEUKIN-4 OR INTERLEUKIN-10 PROLONGS SURVIVAL OF SYNGENEIC PANCREATIC ISLET GRAFTS IN NONOBESE DIABETIC MICE: Islet Graft Survival Does Not Correlate with mRNA Levels of Type 1 or Type 2 Cytokines, or Transforming Growth Factor-?? in the Islet Grafts1 A Rabinovitch, WL Suarez-Pinzon, O Sorensen, RV Rajotte, RF Power	Transplantation	1997
Clinical Pathology of Pancreatic Disorders JA Lott		1997
Prevention of Type I Diabetes and Recurrent β-Cell Destruction of Transplanted Islets* RH Slover, GS Eisenbarth	Endocrine reviews	1997
Pharmacological Approaches to the Prevention of Autoimmune Diabetes: WE Winter, DV House, D Schatz	Drugs	1997
Le diabète sucré insulino-dépendant: une maladie auto-immune à laquelle participent des cellules T R Tisch	Annales de l'Institut Pasteur/Actualités	1996
Prevention of Insulin-dependent Diabetes: Where Are We Now? P Pozzilli	Diabetes/Metabolism Reviews	1996
The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: the Function of the Thymus in the Generation of the Regulatory T Cell Subset A Saoudi, B Seddon, V Heath, D Fowell, D Mason	Immunological Reviews	1996
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice J Tian, M Clere-Salzler, A Herschenfeld, B Middleton, D Newman, R Mueller, S Arita, C Evans, MA Atkinson, Y Mullen, N Sarvetnick, AJ Tobin, PV Lehmann, DL Kaufman	Nature Medicine	1996
Regulation of autoimmune diabetes: Characteristics of non-islet-antigen specific therapies LS Gazda, AG Baxter, KJ Lafferty	Immunology and Cell Biology	1996
Insulin-like growth factor I (IGF-I) delays the onset of diabetes in non-obese diabetic (NOD) mice Y Kaino	Diabetes Research and Clinical Practice	1996
Intranasal Administration of Insulin Peptide B: 9-23 Protects NOD Mice from Diabetes D Daniel, DR Wegmann	Annals of the New York Academy of Sciences	1996
Immunotherapies in diabetes VK Ramiya, NK Maclaren	Trends in Endocrinology & Metabolism	1996
New Strategies in Oral Immunotherapy for Diabetes Prevention A Muir, V Ramiya	Diabetes/Metabolism Reviews	1996
Viruses, cytokines, antigens, and autoimmunity R Gianani, N Sarvetnick	Proceedings of the National Academy of Sciences	1996
Strategies for preventing type I diabetes mellitus CF Verge, GS Eisenbarth	The Western journal of medicine	1996
Checkpoints in the progression of autoimmune disease: lessons from diabetes models I André, A Gonzalez, B Wang, J Katz, C Benoist, D Mathis	Proceedings of the National Academy of Sciences	1996
The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients A Saoudi, B Seddon, D Fowell, D Mason	Journal of Experimental Medicine	1996
The nature of autoantigens targeted in autoimmune endocrine diseases YH Song, Y Li, NK Maclaren	Immunology Today	1996
Lessons from Animal Diabetes VI E Shafrir		1996
Insulin-dependent diabetes mellitus as a ?-cell targeted disease of immunoregulation JF Bach	Journal of Autoimmunity	1995
Glutamic acid decarboxylase and other autoantigens in IDDM GT Nepom	Current Opinion in Immunology	1995
The Th1/Th2 balance in autoimmunity B Charlton, KJ Lafferty	Current Opinion in Immunology	1995
Isohormonal therapy of endocrine autoimmunity N Schloot, GS Eisenbarth	Immunology Today	1995
Genetic analysis of type 1 diabetes using whole genome approaches JA Todd	Proceedings of the National Academy of Sciences	1995
Antigen-specific therapy for autoimmune disease: prospects for the prevention of insulin-dependent diabetes LC Harrison	Molecular Medicine	1995
Nutrition and Immunology DM Klurfeld		1993
Insulin-dependent diabetes mellitus JF Bach	Current Opinion in Immunology	1991

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