Citations to this article

Differential regulation of renal phospholipase C isoforms by catecholamines.
P Y Yu, … , G M Eisner, P A Jose
P Y Yu, … , G M Eisner, P A Jose
Published January 1, 1995
Citation Information: J Clin Invest. 1995;95(1):304-308. https://doi.org/10.1172/JCI117656.
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Differential regulation of renal phospholipase C isoforms by catecholamines.

Abstract

Dopamine and D1 agonists and NE all increase phosphatidyl inositol-specific phospholipase C (PLC) activity, but whereas dopamine produces a natriuresis, NE has an antinatriuretic effect. To determine if catecholamines differentially regulate the expression of PLC isoforms, we infused fenoldopam, a D1 agonist, or pramipexole, a D1/D2 agonist, intravenously or infused fenoldopam or NE into the renal artery of anesthetized rats. After 3-4 h of infusion, when the expected natriuresis (fenoldopam or pramipexole) or antinatriuresis (NE) occurred, the kidneys were removed for analysis of PLC isoform protein expression activity. Western blot analysis revealed that in renal cortical membranes, fenoldopam and pramipexole increased expression of PLC beta 1 and decreased expression of PLC gamma 1; PLC delta was unchanged. In the cytosol, pramipexole and fenoldopam increased expression of both PLC beta 1 and PLC gamma 1. No effects were noted in the medulla. A preferential D1 antagonist, SKF 83742, which by itself had no effect, blocked the effects of pramipexole, thus confirming the involvement of the D1 receptor. In contrast, NE also increased PLC beta 1 but did not affect PLC gamma 1 protein expression in membranes. The changes in PLC isoform expression were accompanied by similar changes in PLC isoform activity. These studies demonstrate for the first time differential regulation of PLC isoforms by catecholamines.

Authors

P Y Yu, L D Asico, G M Eisner, P A Jose

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Year: 2023 2016 2015 2014 2013 2011 2008 2007 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 Total
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Citations to this article (39)

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Z Li, C Yu, Y Han, H Ren, W Shi, C Fu, D He, L Huang, C Yang, X Wang, L Zhou, LD Asico, C Zeng, PA Jose 		American journal of physiology. Heart and circulatory physiology 2008
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Heterozygous knock-Out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse
LD Asico, C Ladines, S Fuchs, D Accili, RM Carey, C Semeraro, F Pocchiari, RA Felder, GM Eisner, PA Jose 		Journal of Clinical Investigation 1998
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Heterozygous knock-Out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse
LD Asico, C Ladines, S Fuchs, D Accili, RM Carey, C Semeraro, F Pocchiari, RA Felder, GM Eisner, PA Jose 		Journal of Clinical Investigation 1998
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Dopamine as a Novel Antimigration and Antiproliferative Factor of Vascular Smooth Muscle Cells Through Dopamine D1-Like Receptors
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A postsynaptic interaction between dopamine D1 and NMDA receptors promotes presynaptic inhibition in the rat nucleus accumbens via adenosine release
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A Postsynaptic Interaction between Dopamine D1 and NMDA Receptors Promotes Presynaptic Inhibition in the Rat Nucleus Accumbens via Adenosine Release
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