Citations to this article

Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.
R P Xiao, … , F O'Connor, E G Lakatta
R P Xiao, … , F O'Connor, E G Lakatta
Published November 1, 1994
Citation Information: J Clin Invest. 1994;94(5):2051-2059. https://doi.org/10.1172/JCI117559.
View: Text | PDF
Research Article

Age-associated changes in beta-adrenergic modulation on rat cardiac excitation-contraction coupling.

Abstract

Previous studies have demonstrated that the ability of beta-adrenergic receptor (beta AR) stimulation to increase cardiac contractility declines with aging. In the present study, the control mechanisms of excitation-contraction (EC) coupling, including calcium current (ICa), cytosolic Ca2+ (Cai2+) transient and contraction in response to beta AR stimulation were investigated in ventricular myocytes isolated from rat hearts of a broad age range (2, 6-8, and 24 mo). While the baseline contractile performance and the Cai2+ transient did not differ markedly among cells from hearts of all age groups, the responses of the Cai2+ transient and contraction to beta-adrenergic stimulation by norepinephrine (NE) diminished with aging: the threshold concentration and the ED50 increased in rank order with aging; the maximum responses of contraction and Cai2+ transient decreased with aging. Furthermore, the efficacy of beta AR stimulation to increase ICa was significantly reduced with aging, and the diminished responses of the contraction and Cai2+ transient amplitudes to NE were proportional to the reductions in the ICa response. These findings suggest that the observed age-associated reduction in beta AR modulation of the cardiac contraction is, in part at least, due to a deficit in modulation of Cai2+, particularly the activity of L-type calcium channels.

Authors

R P Xiao, H A Spurgeon, F O'Connor, E G Lakatta

×

Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 2007 2006 2005 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 3 3 2 2 1 2 2 3 2 1 5 7 2 5 1 2 2 4 1 5 11 8 3 6 4 5 2 94
Citation information

Citations to this article (94)

Title and authors Publication Year
BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts.
Westhoff M, Del Villar SG, Voelker TL, Thai PN, Spooner HC, Costa AD, Sirish P, Chiamvimonvat N, Dickson EJ, Dixon RE 		Nature Communications 2024
Aging-associated atrial fibrillation: A comprehensive review focusing on the potential mechanisms.
Wang MF, Hou C, Jia F, Zhong CH, Xue C, Li JJ 		Aging cell 2024
The Role of Endogenous Opioids in Cardioprotection.
Sirbu C 		Advances in neurobiology 2024
Hallmarks of cardiovascular ageing.
Abdellatif M, Rainer PP, Sedej S, Kroemer G 		Nature reviews. Cardiology 2023
Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes.
Howlett LA, Stevenson-Cocks H, Colman MA, Lancaster MK, Benson AP 		Physiological Reports 2023
Extracellular Vesicles and Cardiac Aging.
Seara FAC, Maciel L, Kasai-Brunswick TH, Nascimento JHM, Campos-de-Carvalho AC 		Advances in experimental medicine and biology 2023
Nanoscale Organization, Regulation, and Dynamic Reorganization of Cardiac Calcium Channels.
Dixon RE 		Frontiers in physiology 2022
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice.
Moen JM, Morrell CH, Matt MG, Ahmet I, Tagirova S, Davoodi M, Petr M, Charles S, de Cabo R, Yaniv Y, Lakatta EG 		GeroScience 2022
Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart
Y Lyu, VK Verma, Y Lee, I Taleb, R Badolia, TS Shankar, CP Kyriakopoulos, CH Selzman, W Caine, R Alharethi, S Navankasattusas, T Seidel, SG Drakos, FB Sachse 		npj Aging and Mechanisms of Disease 2021
Reduced cardiac response to the adrenergic system is a key limiting factor for physical capacity in old age
LA Howlett, MK Lancaster 		Experimental Gerontology 2021
Potential Myocardial Protection of 3,4‐ seco ‐Lupane Triterpenoids from Acanthopanax sessiliflorus Leaves
H Wang, C Chen, R Liu, X Wang, Y Zhao, Z Yan, E Cai, H Zhu 		Chemistry & Biodiversity 2020
Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart
S Hamilton, D Terentyev 		International journal of molecular sciences 2019
Sedentary Behavior, Exercise, and Cardiovascular Health
CJ Lavie, C Ozemek, S Carbone, PT Katzmarzyk, SN Blair 		Circulation research 2019
As time flies by: Investigating cardiac aging in the short-lived Drosophila model
AC Blice-Baum, MC Guida, PS Hartley, PD Adams, R Bodmer, A Cammarato 		Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018
Macrophages: new players in cardiac ageing?
T Bruegmann, GL Smith 		Cardiovascular Research 2018
Metabolic Alterations at the Crossroad of Aging and Oncogenesis
Raffaghello L, Longo V 		International review of cell and molecular biology 2017
Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer.
Prendergast GC, Malachowski WJ, Mondal A, Scherle P, Muller AJ 		International review of cell and molecular biology 2017
Senescence-Associated MicroRNAs.
Munk R, Panda AC, Grammatikakis I, Gorospe M, Abdelmohsen K 		International review of cell and molecular biology 2017
The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms
J Roh, J Rhee, V Chaudhari, A Rosenzweig 		Circulation research 2016
Differential regulation of the β-adrenoceptor density and cyclic AMP level with age and sex in turkey cardiac chambers
S Hoffmann, J Böhme, C Kube, J Haufe, ME Krautwald-Junghanns, G Abraham 		European Journal of Pharmacology 2016
Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy
S Signore, A Sorrentino, G Borghetti, A Cannata, M Meo, Y Zhou, R Kannappan, F Pasqualini, H O'Malley, M Sundman, N Tsigkas, E Zhang, C Arranto, C Mangiaracina, K Isobe, BF Sena, J Kim, P Goichberg, M Nahrendorf, LL Isom, A Leri, P Anversa, M Rota 		Nature Communications 2015
Comprehensive Physiology
SN Cheuvront, RW Kenefick 		Comprehensive Physiology 2014
How cardiomyocyte excitation, calcium release and contraction become altered with age
HA Feridooni, KM Dibb, SE Howlett 		Journal of Molecular and Cellular Cardiology 2014
Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice
TL Domeier, CJ Roberts, AK Gibson, LM Hanft, KS McDonald, SS Segal 		American journal of physiology. Heart and circulatory physiology 2014
Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca2+ signaling
J Liu, S Sirenko, M Juhaszova, SJ Sollott, S Shukla, Y Yaniv, EG Lakatta 		American journal of physiology. Heart and circulatory physiology 2014
Aging and Heart Failure
BI Jugdutt 		2014
Autoantibodies against the β3-adrenoceptor protect from cardiac dysfunction in a rat model of pressure overload
J Wang, M Li, X Ma, K Bai, L Wang, Z Yan, T Lv, Z Zhao, R Zhao, H Liu 		PloS one 2013
Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca 2+ handling in ageing rabbit hearts: Hyperactive oxidized RyR in ageing heart
LL Cooper, W Li, Y Lu, J Centracchio, R Terentyeva, G Koren, D Terentyev 		The Journal of Physiology 2013
Effects of exercise training on cardiovascular adrenergic system
D Leosco, V Parisi, GD Femminella, R Formisano, L Petraglia, E Allocca, D Bonaduce 		Frontiers in physiology 2013
The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells
Yael Yaniv, Alexey E. Lyashkov, Edward G. Lakatta 		Cardiovascular pharmacology: open access 2013
Autoantibodies against the β3-Adrenoceptor Protect from Cardiac Dysfunction in a Rat Model of Pressure Overload
J Wang, M Li, X Ma, K Bai, L Wang, Z Yan, T Lv, Z Zhao, R Zhao, H Liu, WR Bauer 		PloS one 2013
The Impact of Ovariectomy on Calcium Homeostasis and Myofilament Calcium Sensitivity in the Aging Mouse Heart
E Fares, WG Pyle, G Ray, RA Rose, EM Denovan-Wright, RP Chen, SE Howlett, N Beard 		PloS one 2013
The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells.
Yaniv Y, Lyashkov AE, Lakatta EG 		Cardiovascular pharmacology: open access 2013
Profound cardioprotection with timolol in a female rat model of aging-related altered left ventricular function
NN Sozmen, E Tuncay, A Bilginoglu, B Turan 		Canadian Journal of Physiology and Pharmacology 2011
Mitochondria and the aging heart
KR Chaudhary, H El-Sikhry, JM Seubert 		Journal of Geriatric Cardiology 2011
Modulation of sarcoplasmic reticulum Ca2+ cycling in systolic and diastolic heart failure associated with aging
AM Janczewski, EG Lakatta 		Heart Failure Reviews 2010
Effect of age on cardiac excitation-contraction coupling
E Fares, SE Howlett 		Clinical and Experimental Pharmacology and Physiology 2010
Procesos cardiopulmonares y renales en el anciano
JM Vega-Andión 		Medicine - Programa de Formación Médica Continuada Acreditado 2010
Early development of intracellular calcium cycling defects in intact hearts of spontaneously hypertensive rats
S Kapur, GL Aistrup, R Sharma, JE Kelly, R Arora, J Zheng, M Veramasuneni, AH Kadish, CW Balke, JA Wasserstrom 		American journal of physiology. Heart and circulatory physiology 2010
Age-associated changes in excitation-contraction coupling are more prominent in ventricular myocytes from male rats than in myocytes from female rats
SE Howlett 		American journal of physiology. Heart and circulatory physiology 2010
Klinische Kardiologie
E Erdmann 		2009
alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice
SK Park, GP Page, K Kim, DB Allison, M Meydani, R Weindruch, TA Prolla 		The Journal of nutrition 2008
Maladaptation of calcium homoeostasis in aging cardiac myocytes
P Goldspink, S Ruch, T Los, P Buttrick, J García 		Pflügers Archiv - European Journal of Physiology 2008
Exercise promotes angiogenesis and improves β-adrenergic receptor signalling in the post-ischaemic failing rat heart
D Leosco, G Rengo, G Iaccarino, L Golino, M Marchese, F Fortunato, C Zincarelli, E Sanzari, M Ciccarelli, G Galasso, GG Altobelli, V Conti, G Matrone, V Cimini, N Ferrara, A Filippelli, WJ Koch, F Rengo 		Cardiovascular Research 2007
Exercise training and β-blocker treatment ameliorate age-dependent impairment of β-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation
D Leosco, G Rengo, G Iaccarino, A Filippelli, A Lymperopoulos, C Zincarelli, F Fortunato, L Golino, M Marchese, G Esposito, A Rapacciuolo, B Rinaldi, N Ferrara, WJ Koch, F Rengo 		American journal of physiology. Heart and circulatory physiology 2007
Inhibition of iNOS Protects the Aging Heart Against β-Adrenergic Receptor Stimulation-Induced Cardiac Dysfunction and Myocardial Ischemic Injury
D Li, Y Qu, L Tao, H Liu, A Hu, F Gao, S Sharifi-Azad, Z Grunwald, XL Ma, JZ Sun 		Journal of Surgical Research 2006
The Telomere–Telomerase Axis and the Heart
J Kajstura, M Rota, K Urbanek, T Hosoda, C Bearzi, P Anversa, R Bolli, A Leri 		Antioxidants & Redox Signaling 2006
Cardiac excitation-contraction coupling is altered in myocytes from aged male mice but not in cells from aged female mice
SA Grandy, SE Howlett 		American journal of physiology. Heart and circulatory physiology 2006
Calcium spark properties in ventricular myocytes are altered in aged mice
SE Howlett, SA Grandy, GR Ferrier 		American journal of physiology. Heart and circulatory physiology 2006
Views From Within and Beyond: Narratives of Cardiac Contractile Dysfunction Under Senescence
X Yang, N Sreejayan, J Ren 		Endocrine 2005
Peak Mean Myocardial Velocities and Velocity Gradients Measured by Color M-Mode Tissue Doppler Imaging in Healthy Cats
H Koffas, J Dukes-McEwan, BM Corcoran, CM Moran, A French, V Sboros, T Anderson, P Smith, K Simpson, WN McDicken 		Journal of Veterinary Internal Medicine 2003
Insulin improves cardiac myocytes contractile function recovery in simulated ischemia-reperfusion: Key role of Akt
B Zhang, H Zhang, Q Fan, X Ma, F Gao 		Chinese Science Bulletin 2003
Cardiac and thoracic vascular surgery
F Wappler 		Best Practice & Research Clinical Anaesthesiology 2003
Cyclical mechanical stretch-induced apoptosis in myocytes from young rats but necrosis in myocytes from old rats
B Husse, A Sopart, G Isenberg 		American journal of physiology. Heart and circulatory physiology 2003
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part III: Cellular and Molecular Clues to Heart and Arterial Aging
EG Lakatta 		Circulation 2003
Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
CK Lee, DB Allison, J Brand, R Weindruch, TA Prolla 		Proceedings of the National Academy of Sciences 2002
Reversal of Heart Failure Remodeling With Age
TB Levine, AB Levine, J Bolenbaugh, PR Green 		The American Journal of Geriatric Cardiology 2002
Perspectives on mammalian cardiovascular aging: humans to molecules
EG Lakatta, SJ Sollott 		Comparative Biochemistry and Physiology - Part A Molecular & Integrative Physiology 2002
Advances in Cell Aging and Gerontology
T Fülöp, K Hirokawa, G Dupuis, A Larbi, G Pawelec 		Advances in Cell Aging and Gerontology 2002
Cardiovascular ageing in health sets the stage for cardiovascular disease
EG Lakatta 		Heart, Lung and Circulation 2002
Action Potential Prolongation in Cardiac Myocytes of Old Rats is an Adaptation to Sustain Youthful Intracellular Ca2+ Regulation
AM Janczewski, HA Spurgeon, EG Lakatta 		Journal of Molecular and Cellular Cardiology 2002
Patched versus Integrated Analyses of the L-type Ca2+ Currents in Aging Myocytes
G Vassort 		Journal of Molecular and Cellular Cardiology 2002
Alterations in Properties of L-Type Ca Channels in Aging Rat Heart
IR Josephson, A Guia, MD Stern, EG Lakatta 		Journal of Molecular and Cellular Cardiology 2002
Age-dependent agonist-specific dysregulation of membrane-mediated signal transduction: emergence of the gate theory of aging
EJ Yeo, SC Park 		Mechanisms of Ageing and Development 2002
Platelet-Derived Growth Factor-AB Limits the Extent of Myocardial Infarction in a Rat Model: Feasibility of Restoring Impaired Angiogenic Capacity in the Aging Heart
JM Edelberg, SH Lee, M Kaur, L Tang, NM Feirt, S McCabe, O Bramwell, SC Wong, MK Hong 		Circulation 2002
Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons
Edward G Lakatta 		Heart Failure Reviews 2002
Signal Transduction from Bradykinin, Angiotensin, Adrenergic and Muscarinic Receptors to Effector Enzymes, Including ADP-Ribosyl Cyclase
H Higashida, S Yokoyama, N Hoshi, M Hashii, A Egorova, ZG Zhong, M Noda, M Shahidullah, M Taketo, R Knijnik, Y Kimura, H Takahashi, XL Chen, Y Shin, JS Zhang 		Biological Chemistry 2001
Effects Of Ageing On The Activation Metabolism Of Rat Papillary Muscles
H Kiriazis, CL Gibbs 		Clinical and Experimental Pharmacology and Physiology 2001
Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase
H Higashida, M Hashii, S Yokoyama, N Hoshi, XL Chen, A Egorova, M Noda, JS Zhang 		Pharmacology & Therapeutics 2001
Cyclic ADP-ribose as a potential second messenger for neuronal Ca2+signaling
H Higashida, M Hashii, S Yokoyama, N Hoshi, K Asai, T Kato 		Journal of Neurochemistry 2001
Heart Physiology and Pathophysiology
NS Dhalla, RM Temsah, T Netticadan, MS Sandhu 		Heart Physiology and Pathophysiology 2001
Augmented Age-associated Innate Immune Responses Contribute to Negative Inotropic and Lusitropic Effects of Lipopolysaccharide and Interferon γ
GO Rosas, SJ Zieman, M Donabedian, K Vandegaer, JM Hare 		2001
Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells
SQ Wang, LS Song, EG Lakatta, H Cheng 		Nature 2001
β-Adrenergic Stimulation Synchronizes Intracellular Ca 2+ Release During Excitation-Contraction Coupling in Cardiac Myocytes
LS Song, SQ Wang, RP Xiao, H Spurgeon, EG Lakatta, H Cheng 		Circulation research 2001
Research Agenda for Cardiovascular Aging: Humans to Molecules
EG Lakatta 		The American Journal of Geriatric Cardiology 2000
CARDIOVASCULAR AGING IN HEALTH
EG Lakatta 		Clinics in Geriatric Medicine 2000
Aging-associated changes in whole cell K + and L-type Ca 2+ currents in rat ventricular myocytes
SJ Liu, RP Wyeth, RB Melchert, RH Kennedy 		American journal of physiology. Heart and circulatory physiology 2000
Influence of Aging on Systolic Left Ventricular Wall Motion Velocities Along the Long and Short Axes in Clinically Normal Patients Determined by Pulsed Tissue Doppler Imaging
Y Onose, T Oki, Y Mishiro, H Yamada, M Abe, K Manabe, Y Kageji, T Tabata, T Wakatsuki, S Ito 		Journal of the American Society of Echocardiography 1999
CARDIOVASCULAR CONSEQUENCES OF THE AGING PROCESS
SP Schulman 		Cardiology Clinics 1999
Calcium cycling in the aged heart
YY Zhou, EG akatta, RP Xiao 		The Asia Pacific Heart Journal 1999
Chronic Administration of Nifedipine Induces Up-regulation of Functional Calcium Channels in Rat Myocardium
PE Morgan, EA Aiello, GE de Cingolani, AR Mattiazzi, HE Cingolani 		Journal of Molecular and Cellular Cardiology 1999
Cardiovascular Aging Research: The Next Horizons
EG Lakatta 		Journal of the American Geriatrics Society 1999
Aging-dependent depression in the kinetics of force development in rat skinned myocardium
DP Fitzsimons, JR Patel, RL Moss 		American journal of physiology. Heart and circulatory physiology 1999
Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases
RP Xiao, ED Tomhave, DJ Wang, X Ji, MO Boluyt, H Cheng, EG Lakatta, WJ Koch 		Journal of Clinical Investigation 1998
Age and gender differences in excitation-contraction coupling of the rat ventricle
N Leblanc, D Chartier, H Gosselin, JL Rouleau 		The Journal of Physiology 1998
Advances in Organ Biology
AJ Liedtke 		Advances in Organ Biology 1998
Age-Associated Alterations in Calcium Current and its Modulation in Cardiac Myocytes:
YY Zhou, EG Lakatta, RP Xiao 		Drugs & Aging 1998
Techniques for high-speed cardiac magnetic resonance imaging in rats and rabbits
WG Rehwald, SB Reeder, ER McVeigh, RM Judd 		Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1997
Inotropic Response of Rat Heart Papillary Muscle to α1-and β-Adrenoceptor Stimulation in Relation to Dietary n-6 and n-3 Polyunsaturated Fatty Acids (PUFA) and Age
GV Skúladóttir, M Jóhannsson 		Pharmacology & Toxicology 1997
Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure
N Ferrara, K Davia, P Abete, F Rengo, SE Harding 		Aging clinical and experimental research 1997
Effects of Aging on Left Ventricular Relaxation in Humans: Analysis of Left Ventricular Isovolumic Pressure Decay
T Yamakado, E Takagi, S Okubo, K Imanaka-Yoshida, T Tarumi, M Nakamura, T Nakano 		Circulation 1997
‘Cross Talk’ Between Opioid Peptide and Adrenergic Receptor Signaling in Isolated Rat Heart
S Pepe, RP Xiao, C Hohl, R Altschuld, EG Lakatta 		Circulation 1997
Age-related differential susceptibility to calcium channel blocker and low calcium medium in rat detrusor muscle: Response to field stimulation
HJ Yu, AJ Wein, RM Levin 		Neurourology and Urodynamics 1996
Exercise training improves lusitropy by isoproterenol in papillary muscles from aged rats
GE Taffet, LA Michael, CA Tate 		Journal of applied physiology 1996

Advertisement