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Citations to this article

Intercellular adhesion molecule-1 is upregulated on peripheral blood T lymphocyte subsets in dual asthmatic responders.
V De Rose, … , P Baderna, E Pozzi
V De Rose, … , P Baderna, E Pozzi
Published November 1, 1994
Citation Information: J Clin Invest. 1994;94(5):1840-1845. https://doi.org/10.1172/JCI117533.
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Research Article

Intercellular adhesion molecule-1 is upregulated on peripheral blood T lymphocyte subsets in dual asthmatic responders.

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Abstract

To examine the role of adhesion molecules in T cell recruitment and activation during allergen-induced late asthmatic response (LAR), we evaluated the expression of lymphocyte function-associated antigen-1 alpha (LFA-1 alpha) and intercellular adhesion molecule-1 (ICAM-1) on peripheral blood T lymphocyte subsets from atopic asthmatic patients and their changes following allergen inhalation challenge. 12 atopic asthmatic patients were studied. Six patients showed only a single early response after allergen challenge, and six developed a dual response. At baseline, dual responders (DR) had a significantly higher expression of ICAM-1 on CD4+ and CD8+ T lymphocytes as compared with both single early responders (P < 0.005 and P < 0.02, respectively) and controls (P < 0.001, both comparisons). Allergen challenge was followed by a decrease of CD8+ ICAM-1+ T lymphocytes in all DR (P < 0.05) and of CD4+ ICAM-1+ T lymphocytes in four out of six DR, at the time of the LAR. At the same time, a significant rise in serum levels of the soluble form of ICAM-1 was observed in DR. These results suggest that peripheral blood immunoregulatory T lymphocytes are in a higher state of activation in DR as compared with early responders. The upregulation of ICAM-1 on these cells may be important in enhancing airway inflammation in patients with LAR.

Authors

V De Rose, G Rolla, C Bucca, P Ghio, M Bertoletti, P Baderna, E Pozzi

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Total citations by year

Year: 2018 2011 2009 2007 2004 2003 2002 1998 1997 Total
Citations: 1 1 1 1 1 1 3 2 1 12
Citation information
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Citations to this article (12)

Title and authors Publication Year
ICAM-1 controls development and function of ILC2
AH Lei, Q Xiao, GY Liu, K Shi, Q Yang, X Li, YF Liu, HK Wang, WP Cai, YJ Guan, DI Gabrilovich, J Zhou
Journal of Experimental Medicine 2018
Delayed asthmatic response: a new phenotype of bronchial response to allergen challenge and soluble adhesion molecules in the serum
Z Pelikan
Annals of Allergy, Asthma & Immunology 2011
Surface markers of lymphocyte activation in pregnant asthmatics
A Bohács, E Pállinger, L Tamási, J Rigó, Z Komlósi, V Müller, Y Dong, P Magyar, A Falus, G Losonczy
Inflammation Research 2009
The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention
AR Klein), U Friedrich, H Vogelsang, A Bauer, M Kaatz, UC Hipler, I Schmidt, G Jahreis
Clinical & Experimental Allergy 2007
IFN-γ inhibits the proliferation of allergen-activated T lymphocytes from atopic, asthmatic patients by inducing Fas/FasL-mediated apoptosis
VD Rose, P Cappello, V Sorbello, B Ceccarini, F Gani, M Bosticardo, S Fassio, F Novelli
Journal of leukocyte biology 2004
Decreased intercellular adhesion molecule-1 (CD54) and L-selectin (CD62L) expression on peripheral blood natural killer cells in asthmatic children with acute exacerbation
SJ Lin, LY Chang, DC Yan, YJ Huang, TJ Lin, TY Lin
Allergy 2003
IL-10 production in circulating T cells differs between allergen-induced isolated early and dual asthmatic responders
K Matsumoto, GM Gauvreau, T Rerecich, RM Watson, LJ Wood, PM O'Byrne
Journal of Allergy and Clinical Immunology 2002
Regulation of lymphocyte clustering by CD30-mediated ICAM-1 up-regulation
SY Nam, KS Cho, YM Heo, JC Ha, YH Kim, HK Yi, PH Hwang, HM Kim, ER Podack
Cellular Immunology 2002
Circulating adhesion molecules in sera of asthmatic children
RB Tang, SJ Chen, WJ Soong, RL Chung
Pediatric Pulmonology 2002
Circulating Adhesion Molecules in Cystic Fibrosis
V De Rose, A Oliva, B Messore, B Grosso, C Mollar, E Pozzi
American journal of respiratory and critical care medicine 1998
Involvement of Intercellular Adhesion Molecule-1 in the Antigen-induced Infiltration of Eosinophils and Lymphocytes into the Airways in a Murine Model of Pulmonary Inflammation
JE Chin, GE Winterrowd, CA Hatfield, JR Brashler, RL Griffin, SL Vonderfecht, KP Kolbasa, SF Fidler, KL Shull, RF Krzesicki, KA Ready, CJ Dunn, LM Sly, ND Staite, IM Richards
American journal of respiratory cell and molecular biology 1998
Differential up-regulation of circulating soluble and endothelial cell intercellular adhesion molecule-1 in mice
S Komatsu, S Flores, ME Gerritsen, DC Anderson, DN Granger
The American Journal of Pathology 1997

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