R R Lobb, M E Hemler
Title and authors | Publication | Year |
---|---|---|
Immune-mediated regeneration of cell-free vascular grafts in an ovine model
Nasiri B, Das A, Ramachandran K, Bhamidipati SH, Wu Y, Venkatesan S, Gunawan R, Swartz DD, Andreadis ST |
NPJ Regenerative Medicine | 2025 |
Conjecturing about Small-Molecule Agonists and Antagonists of α4β1 Integrin: From Mechanistic Insight to Potential Therapeutic Applications
He T, Giacomini D, Tolomelli A, Baiula M, Gentilucci L |
Biomedicines | 2024 |
Harnessing the potential of monocytes/macrophages to regenerate tissue-engineered vascular grafts
Das A, Smith RJ, Andreadis ST |
Cardiovascular Research | 2024 |
Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury
Mannes PZ, Barnes CE, Biermann J, Latoche JD, Day KE, Zhu Q, Tabary M, Xiong Z, Nedrow JR, Izar B, Anderson CJ, Villanueva FS, Lee JS, Tavakoli S |
Proceedings of the National Academy of Sciences | 2023 |
Design and Pharmacological Characterization of α4β1 Integrin Cyclopeptide Agonists: Computational Investigation of Ligand Determinants for Agonism versus Antagonism
Anselmi M, Baiula M, Spampinato S, Artali R, He T, Gentilucci L |
Journal of Medicinal Chemistry | 2023 |
Are the integrin binding motifs within SARS CoV-2 spike protein and MHC class II alleles playing the key role in COVID-19?
Gerencer M, McGuffin LJ |
Frontiers in immunology | 2023 |
Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid Nanoparticles.
Swart LE, Fens MHAM, van Oort A, Waranecki P, Mata Casimiro LD, Tuk D, Hendriksen M, van den Brink L, Schweighart E, Seinen C, Nelson R, Krippner-Heidenreich A, O'Toole T, Schiffelers RM, Kooijmans S, Heidenreich O |
Pharmaceutics | 2023 |
Monocyte Recruitment for Vascular Tissue Regeneration.
Nasiri B, Yi T, Wu Y, Smith RJ Jr, Podder AK, Breuer CK, Andreadis ST |
Advanced Healthcare Materials | 2022 |
Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans
V Fleischer, G Gonzalez-Escamilla, D Ciolac, P Albrecht, P Küry, J Gruchot, M Dietrich, C Hecker, T Müntefering, S Bock, M Oshaghi, A Radetz, M Cerina, J Krämer, L Wachsmuth, C Faber, H Lassmann, T Ruck, SG Meuth, M Muthuraman, S Groppa |
Proceedings of the National Academy of Sciences | 2021 |
Severe anti-PD1-related meningoencephalomyelitis successfully treated with anti-integrin alpha4 therapy
S Basin, J Perrin, JM Michot, O Lambotte, C Cauquil |
European Journal of Cancer | 2021 |
Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies
S Paul, E Candelario-Jalil |
Experimental Neurology | 2021 |
Immune checkpoint inhibitor-induced aseptic meningitis and encephalitis: a case-series and narrative review
L Thouvenin, T Olivier, G Banna, A Addeo, A Friedlaender |
Therapeutic Advances in Drug Safety | 2021 |
Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke?
Stuckey SM, Ong LK, Collins-Praino LE, Turner RJ |
International journal of molecular sciences | 2021 |
Perivascular Lymphocyte Clusters Induced by Gastric Subserous Layer Vaccination Mediate Optimal Immunity against Helicobacter through Facilitating Immune Cell Infiltration and Local Antibody Response
C Hu, W Liu, N Xu, A Huang, Z Zeng, S Luo, Z Zhang, M Fan, F Ye, , Y Xing |
Journal of Immunology Research | 2020 |
AJM300, a novel oral antagonist of α4‐integrin, sustains an increase in circulating lymphocytes: A randomised controlled trial in healthy male subjects
H Fukase, T Kajioka, I Oikawa, N Ikeda, H Furuie |
British Journal of Clinical Pharmacology | 2020 |
The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins
DN Edwards, GJ Bix |
Frontiers in neuroscience | 2019 |
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection
M Pardons, AE Baxter, M Massanella, A Pagliuzza, R Fromentin, C Dufour, L Leyre, JP Routy, DE Kaufmann, N Chomont, R Swanstrom |
PLoS pathogens | 2019 |
AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients
L Núñez, GM Marrón-Liñares, MG Crespo-Leiro, E Barge-Caballero, E Álvarez-López, N Suarez-Fuentetaja, MJ Paniagua-Martin, J Pombo, J Muñiz, CD Tan, ER Rodríguez, JM Vázquez-Rodríguez, M Hermida-Prieto, S Stepkowski |
PloS one | 2019 |
Response to: Kobayashi et al.: “Erythroblast appearance associated with natalizumab” Multiple Sclerosis and Related Disorders 2019
K Akgün, M Bornhäuser, T Ziemssen |
Multiple Sclerosis and Related Disorders | 2019 |
Efficient Multikilogram Synthesis of a VLA-4 Antagonist via a Povarov Reaction
P Cerfontaine, F Driessens, MF Deltent, S Petit |
Organic Process Research & Development | 2019 |
Perivascular Adventitial Fibroblast Specialization Accompanies T Cell Retention in the Inflamed Human Dermis
AM Barron, JC Mantero, JD Ho, B Nazari, KL Horback, J Bhawan, R Lafyatis, C Lam, JL Browning |
Journal of immunology (Baltimore, Md. : 1950) | 2018 |
JC Virus-DNA Detection Is Associated with CD8 Effector Accumulation in Peripheral Blood of Patients with Multiple Sclerosis under Natalizumab Treatment, Independently from JC Virus Serostatus
MA Zingaropoli, M Iannetta, S Pontecorvo, E Anzivino, C Prezioso, DM Rodio, M Morreale, A DAbramo, A Oliva, M Lichtner, A Cortese, M Frontoni, V Pietropaolo, A Francia, CM Mastroianni, V Vullo, MR Ciardi |
BioMed Research International | 2018 |
Real-World Lab Data in Natalizumab Treated Multiple Sclerosis Patients Up to 6 Years Long-Term Follow Up
M Kaufmann, R Haase, U Proschmann, T Ziemssen, K Akgün |
Frontiers in neurology | 2018 |
Natalizumab may control immune checkpoint inhibitor–induced limbic encephalitis
AF Hottinger, R de Micheli, V Guido, A Karampera, P Hagmann, RD Pasquier |
Neurology: Neuroimmunology & Neuroinflammation | 2018 |
Anti-α4β1 Integrin Antibodies Attenuated Brain Inflammatory Changes in a Mouse Model of Alzheimer’s Disease
G Manocha, A Ghatak, K Puig, C Combs |
Current Alzheimer research | 2018 |
Progressive Multifocal Leukoencephalopathy
E Grebenciucova, JR Berger |
Neurologic Clinics | 2018 |
Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype
S Joshi, AR Singh, SS Wong, M Zulcic, M Jiang, A Pardo, M Selman, JS Hagood, DL Durden, LM Schnapp |
PloS one | 2017 |
Infections in Patients Receiving Multiple Sclerosis Disease-Modifying Therapies
E Grebenciucova, A Pruitt |
Current Neurology and Neuroscience Reports | 2017 |
Natalizumab in Multiple Sclerosis: Long-Term Management
M Clerico, C Artusi, A Liberto, S Rolla, V Bardina, P Barbero, S Mercanti, L Durelli |
International journal of molecular sciences | 2017 |
The use of natalizumab for multiple sclerosis
R Brandstadter, IK Sand |
Neuropsychiatric Disease and Treatment | 2017 |
Long-term safety evaluation of natalizumab for the treatment of multiple sclerosis
M Clerico, CA Artusi, AD Liberto, S Rolla, V Bardina, P Barbero, SF de Mercanti, L Durelli |
Expert Opinion on Drug Safety | 2017 |
High cumulative JC virus seroconversion rate during long-term use of natalizumab
A Vennegoor, JA van Rossum, C Leurs, MP Wattjes, T Rispens, JL Murk, BM Uitdehaag, J Killestein |
European Journal of Neurology | 2016 |
The Lhx9-integrin pathway is essential for positioning of the proepicardial organ
P Tandon, CM Wilczewski, CE Williams, FL Conlon |
Development (Cambridge, England) | 2016 |
Natalizumab Affects T-Cell Phenotype in Multiple Sclerosis: Implications for JCV Reactivation
M Iannetta, MA Zingaropoli, A Bellizzi, M Morreale, S Pontecorvo, A DAbramo, A Oliva, E Anzivino, SL Menzo, C DAgostino, CM Mastroianni, E Millefiorini, V Pietropaolo, A Francia, V Vullo, MR Ciardi, RS Fujinami |
PloS one | 2016 |
Development of bionic invasion membrane for the study of multiple sclerosis
CY Lee, KF Lei, CL Ku, CH Huang |
2016 IEEE 11th Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) | 2016 |
Antisense oligonucleotides in therapy for neurodegenerative disorders
MM Evers, LJ Toonen, WM van Roon-Mom |
Advanced Drug Delivery Reviews | 2015 |
Cellular immune surveillance of central nervous system bypasses blood-brain barrier and blood-cerebrospinal-fluid barrier: Revealed with the New Marburg cerebrospinal-fluid model in healthy humans: Human CSF Thoracic Duct Chyle Immune Surveillance
TO Kleine |
Cytometry Part A | 2015 |
Association of fibronectin Msp iv polymorphism and diabetic nephropathy susceptibility in Chinese Han population
Jinxiang Gao, Xuezhong Zhang, Huiling Diao, Yunqi Liu, Min Lv, Hua Dong, Xiaomin Zhang, Yaning Wang |
International journal of clinical and experimental pathology | 2015 |
Elevated expression of CX3C chemokine receptor 1 mediates recruitment of T cells into bone marrow of patients with acquired aplastic anaemia
J Ren, XY Hou, SH Ma, FK Zhang, JH Zhen, L Sun, YX Sun, YL Hao, YF Cheng, M Hou, CG Xu, MH Zhang, J Peng |
Journal of Internal Medicine | 2014 |
Rac2 controls tumor growth, metastasis and m1-m2 macrophage differentiation in vivo
S Joshi, AR Singh, M Zulcic, L Bao, K Messer, T Ideker, J Dutkowski, DL Durden |
PloS one | 2014 |
Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells
B Cao, OE Hutt, Z Zhang, S Li, SY Heazlewood, B Williams, JA Smith, DN Haylock, GP Savage, SK Nilsson |
Organic & Biomolecular Chemistry | 2014 |
Natalizumab for multiple sclerosis: appraising risk versus benefit, a seemingly demanding tango
S Gupta, B Weinstock-Guttman |
Expert Opinion on Biological Therapy | 2014 |
Investigation of the teratogenic potential of VLA-4 antagonist derivatives in rats
K Sakurai, T Matsuoka, C Suzuki, J Kinoshita, G Takayama, K Shimomura |
Reproductive Toxicology | 2014 |
Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 1 Historical and established therapies
SA Broadley, MH Barnett, M Boggild, BJ Brew, H Butzkueven, R Heard, S Hodgkinson, AG Kermode, J Lechner-Scott, RA Macdonell, M Marriott, DF Mason, J Parratt, SW Reddel, CP Shaw, M Slee, J Spies, BV Taylor, WM Carroll, TJ Kilpatrick, J King, PA McCombe, JD Pollard, E Willoughby |
Journal of Clinical Neuroscience | 2014 |
Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo
S Joshi, AR Singh, M Zulcic, L Bao, K Messer, T Ideker, J Dutkowski, DL Durden, M Chrzanowska-Wodnicka |
PloS one | 2014 |
PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth
MC Schmid, I Franco, SW Kang, E Hirsch, LA Quilliam, JA Varner |
PloS one | 2013 |
Clinical effects of natalizumab on multiple sclerosis appear early in treatment course
L Kappos, PW O’Connor, CH Polman, P Vermersch, H Wiendl, A Pace, A Zhang, C Hotermans |
Journal of Neurology | 2013 |
Elevated risk of opportunistic viral infection in patients with Crohn’s disease during biological therapies: a meta analysis of randomized controlled trials
X Wang, F Zhou, J Zhao, R Zhou, M Huang, J Li, W Wang, S Xu, B Xia |
European Journal of Clinical Pharmacology | 2013 |
QSAR study of α1β4 integrin inhibitors by GA-MLR and GA-SVM methods
E Pourbasheer, R Aalizadeh, MR Ganjali, P Norouzi |
Structural Chemistry | 2013 |
Inhibition of PI3 Kinase Gamma Enzyme by Novel Phenylpyrazoles
S Bepary, IK Youn, HJ Lim, GH Lee |
Bulletin of the Korean Chemical Society | 2013 |
PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth
MC Schmid, I Franco, SW Kang, E Hirsch, LA Quilliam, JA Varner, D Gullberg |
PloS one | 2013 |
Perspectives in inflammation biology
ER Banerjee |
2013 | |
Inhibition of Selective Adhesion Molecules in Treatment of Inflammatory Bowel Disease
N Ghosh, R Chaki, SC Mandal |
International Reviews of Immunology | 2012 |
Antisense-mediated RNA targeting: versatile and expedient genetic manipulation in the brain
I Zalachoras, MM Evers, WM van Roon-Mom, AM Aartsma-Rus, OC Meijer |
Frontiers in molecular neuroscience | 2011 |
Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
MC Schmid, CJ Avraamides, HC Dippold, I Franco, P Foubert, LG Ellies, LM Acevedo, JR Manglicmot, X Song, W Wrasidlo, SL Blair, MH Ginsberg, DA Cheresh, E Hirsch, SJ Field, JA Varner |
Cancer Cell | 2011 |
Heterogeneity of the Mechanisms of Nerve Cell Damage in Demyelinating Autoimmune Diseases of the CNS
IN Abdurasulova, VM Klimenko |
Neuroscience and Behavioral Physiology | 2011 |
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné |
Advances in Immunology Volume 110 | 2011 |
Age-Specific Changes of Mesenchymal Stem Cells Are Paralleled by Upregulation of CD106 Expression As a Response to an Inflammatory Environment
GT Laschober, R Brunauer, A Jamnig, S Singh, U Hafen, C Fehrer, F Kloss, R Gassner, G Lepperdinger |
Rejuvenation Research | 2011 |
Autoimmunity and inflammation: murine models and translational studies
SW Hall, A Cooke |
Mammalian Genome | 2011 |
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee |
Annual Reports in Medicinal Chemistry Volume 46 | 2011 |
Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients
FI Staquicini, M Cardó-Vila, MG Kolonin, M Trepel, JK Edwards, DN Nunes, A Sergeeva, E Efstathiou, J Sun, NF Almeida, SM Tu, GH Botz, MJ Wallace, DJ O'Connell, S Krajewski, JE Gershenwald, JJ Molldrem, AL Flamm, E Koivunen, RD Pentz, E Dias-Neto, JC Setubal, DJ Cahill, P Troncoso, KA Do, CJ Logothetis, RL Sidman, R Pasqualini, W Arap |
Proceedings of the National Academy of Sciences | 2011 |
The Toronto Observational Study of Natalizumab in Multiple Sclerosis
KM Krysko, PW O'Connor |
CAN J NEUROL SCI | 2011 |
Investigational new drugs in the treatment of inflammatory bowel disease: a review
J Goh, I Williams |
Journal of Experimental Pharmacology | 2011 |
Anti-adhesion molecule therapy for inflammatory bowel disease
S Ghosh, R Panaccione |
Therapeutic advances in gastroenterology | 2010 |
Heterodimeric integrin complexes containing beta1-integrin promote internalization and lethality of anthrax toxin
M Martchenko, SY Jeong, SN Cohen |
Proceedings of the National Academy of Sciences | 2010 |
Natalizumab (Tysabri)
DT Selewski, GV Shah, BM Segal, PA Rajdev, SK Mukherji |
American Journal of Neuroradiology | 2010 |
Natalizumab has no direct biological effect on JC virus infectivity in permissive human neural cell lines
T Suzuki, S Yamanouchi, Y Sunden, Y Orba, T Kimura, H Sawa |
Journal of Medical Virology | 2010 |
Progressive multifocal leukoencephalopathy and antipsoriatic drugs
VD Lernia |
International Journal of Dermatology | 2010 |
Natalizumab Therapy of Multiple Sclerosis
M Hutchinson |
Journal of Interferon & Cytokine Research | 2010 |
Overlapping and distinct mechanisms of action of multiple sclerosis therapies
JJ Graber, CA McGraw, D Kimbrough, S Dhib-Jalbut |
Clinical Neurology and Neurosurgery | 2010 |
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
Review: Anti-adhesion molecule therapy for inflammatory bowel disease
S Ghosh, R Panaccione |
Therapeutic advances in gastroenterology | 2010 |
IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors
K Sasaki, AD Pardee, Y Qu, X Zhao, R Ueda, G Kohanbash, LM Bailey, H Okada, R Muthuswamy, P Kalinski, PH Basse, LD Falo, WJ Storkus |
Journal of immunotherapy (Hagerstown, Md. : 1997) | 2009 |
Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models
ER Banerjee, Y Jiang, WR Henderson, Y Latchman, T Papayannopoulou |
Experimental Hematology | 2009 |
Leukocyte integrins and their ligand interactions
YM Hyun, CT Lefort, M Kim |
Immunologic Research | 2009 |
Thrombin induces fibronectin-specific migration of pulmonary microvascular endothelial cells: requirement of calcium/calmodulin-dependent protein kinase II
DF Meoli, RJ White |
American journal of physiology. Lung cellular and molecular physiology | 2009 |
Replication of celiac disease UK genome-wide association study results in a US population
CP Garner, JA Murray, YC Ding, Z Tien, DA van Heel, SL Neuhausen |
Human Molecular Genetics | 2009 |
An evidence-based review of natalizumab therapy in the management of Crohn's disease
RG Edula, MF Picco |
Therapeutics and Clinical Risk Management | 2009 |
Natalizumab update: a story of benefit and risk
LJ Barten, DR Allington, KA Procacci, MP Rivey |
Drug Discovery Today: Therapeutic Strategies | 2009 |
Characterization of α4β1 (CD49d/CD29) on equine leukocytes: Potential utility of a potent α4β1 (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction)
KM Treonze, K Alves, P Fischer, WK Hagmann, D Hora, A Kulick, K Vakerich, ND Smith, RB Lingham, S Maniar |
Veterinary Immunology and Immunopathology | 2009 |
Thrombin induces fibronectin-specific migration of pulmonary microvascular endothelial cells: requirement of calcium/calmodulin-dependent protein kinase II
DF Meoli, RJ White |
American journal of physiology. Lung cellular and molecular physiology | 2009 |
Review: Natalizumab in the treatment of multiple sclerosis
Ö Yaldizli, N Putzki |
Therapeutic advances in neurological disorders | 2009 |
Lack of Functional P-Selectin Ligand Exacerbates Salmonella Serovar Typhimurium Infection
WW Kum, S Lee, GA Grassl, R Bidshahri, K Hsu, HJ Ziltener, BB Finlay |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
GLANCE: results of a phase 2, randomized, double-blind, placebo-controlled study.
Goodman AD, Rossman H, Bar-Or A, Miller A, Miller DH, Schmierer K, Lublin F, Khan O, Bormann NM, Yang M, Panzara MA, Sandrock AW |
Neurology | 2009 |
Fibronectin bridges monocytes and reticulocytes via integrin alpha4beta1
JE Brittain, CM Knoll, KI Ataga, EP Orringer, LV Parise |
British Journal of Haematology | 2008 |
Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity
CC Féral, JG Neels, C Kummer, M Slepak, JM Olefsky, MH Ginsberg |
Diabetes | 2008 |
JunB as a potential mediator of PTHrP actions: new gene targets Ephrin B1 and VCAM-1
JE Berry, GJ Pettway, KG Cordell, T Jin, NS Datta, LK McCauley |
Oral Diseases | 2008 |
The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration
K Ito, S Kon, Y Nakayama, D Kurotaki, Y Saito, M Kanayama, C Kimura, H Diao, J Morimoto, Y Matsui, T Uede |
Matrix biology : journal of the International Society for Matrix Biology | 2008 |
Anti-Adhesion Molecule Strategies for Crohn Disease
Y Leung, R Panaccione |
BioDrugs | 2008 |
IL-4 inhibits VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit
K Sasaki, AD Pardee, H Okada, WJ Storkus |
European Journal of Immunology | 2008 |
An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury
F Bao, Y Chen, KA Schneider, LC Weaver |
Experimental Neurology | 2008 |
α4β1 integrin blockade after spinal cord injury decreases damage and improves neurological function
JC Fleming, F Bao, Y Chen, EF Hamilton, JK Relton, LC Weaver |
Experimental Neurology | 2008 |
Constraining the amide bond in N-Sulfonylated dipeptide VLA-4 antagonists
LL Chang, GX Yang, E McCauley, RA Mumford, JA Schmidt, WK Hagmann |
Bioorganic & Medicinal Chemistry Letters | 2008 |
Synthetic study of VLA-4/VCAM-1 inhibitors: Synthesis and structure–activity relationship of piperazinylphenylalanine derivatives
O Saku, K Ohta, E Arai, Y Nomoto, H Miura, H Nakamura, E Fuse, Y Nakasato |
Bioorganic & Medicinal Chemistry Letters | 2008 |
Ligand binding of leukocyte integrin very late antigen-4 involves exposure of sulfhydryl groups and is subject to redox modulation
SY Liu, MY Tsai, KP Chuang, YF Huang, CC Shieh |
European Journal of Immunology | 2008 |
Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
S Dijkstra, G Kooij, R Verbeek, SM der Pol, S Amor, EE Geisert, CD Dijkstra, JM Noort, HE Vries |
Neurobiology of Disease | 2008 |
Immunogenicity of Biopharmaceuticals
M van de Weert, EH Møller |
2008 | |
Multi-cell Agent-based Simulation of the Microvasculature to Study the Dynamics of Circulating Inflammatory Cell Trafficking
AM Bailey, BC Thorne, SM Peirce |
Annals of Biomedical Engineering | 2007 |
Therapeutic effect of all-trans-retinoic acid (at-RA) on an autoimmune nephritis experimental model: role of the VLA-4 integrin
MM Escribese, E Conde, A Martín, D Sáenz-Morales, D Sancho, GP de Lema, J Lucio-Cazaña, F Sánchez-Madrid, ML García-Bermejo, FM Mampaso |
BMC Nephrology | 2007 |
Natalizumab: A new treatment for relapsing remitting multiple sclerosis
M Hutchinson |
Therapeutics and Clinical Risk Management | 2007 |
Natalizumab for the Treatment of Active Crohn’s Disease: Results of the ENCORE Trial
SR Targan, BG Feagan, RN Fedorak, BA Lashner, R Panaccione, DH Present, ME Spehlmann, PJ Rutgeerts, Z Tulassay, M Volfova, DC Wolf, C Hernandez, J Bornstein, WJ Sandborn |
Gastroenterology | 2007 |
Natalizumab (Tysabri) Treatment for Relapsing Multiple Sclerosis
KP Johnson |
The Neurologist | 2007 |
2,6-Quinolinyl derivatives as potent VLA-4 antagonists
MA Lassoie, F Broeders, P Collart, L Defrère, F Laveleye-Defais, T Demaude, A Gassama, G Guillaumet, JC Hayez, L Kiss, L Knerr, JM Nicolas, S Norsikian, L Quéré, S Routier, V Verbois, L Provins |
Bioorganic & Medicinal Chemistry Letters | 2007 |
Highly constrained bicyclic VLA-4 antagonists
LL Chang, Q Truong, GA Doss, M MacCoss, K Lyons, E McCauley, R Mumford, G Forrest, S Vincent, JA Schmidt, WK Hagmann |
Bioorganic & Medicinal Chemistry Letters | 2007 |
α4 and β2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only α4 is critical
ER Banerjee, Y Jiang, WR Henderson, LM Scott, T Papayannopoulou |
Experimental Hematology | 2007 |
Peptides Derived from Fibronectin Type III Connecting Segments Promote Endothelial Cell Adhesion but Not Platelet Adhesion: Implications in Tissue-Engineered Vascular Grafts
EJ Rodenberg, FM Pavalko |
Tissue Engineering | 2007 |
Effect of enalapril on the in vitro and in vivo peptidyl cleavage of a potent VLA-4 antagonist
BV Karanam, A Jayraj, M Rabe, Z Wang, C Keohane, J Strauss, S Vincent |
Xenobiotica | 2007 |
VLA-4 blockade suppresses endotoxin-induced uveitis: in vivo evidence for functional integrin up-regulation
A Hafezi-Moghadam, K Noda, L Almulki, EF Iliaki, V Poulaki, KL Thomas, T Nakazawa, T Hisatomi, JW Miller, ES Gragoudas |
The FASEB Journal | 2007 |
Intracellular signaling required for CCL25-stimulated T cell adhesion mediated by the integrin α4β1
M Parmo-Cabañas, D García-Bernal, R García-Verdugo, L Kremer, G Márquez, J Teixidó |
Journal of leukocyte biology | 2007 |
Adhesion Molecules: Function and Inhibition
K Ley |
2007 | |
Biologics in General Medicine
WH Boehncke, HH Radeke |
2007 | |
Phenotype and Effector Function of CC Chemokine Receptor 9-Expressing Lymphocytes in Small Intestinal Crohn’s Disease
M Saruta, QT Yu, A Avanesyan, PR Fleshner, SR Targan, KA Papadakis |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8+ T-cell-depleted macaques that develop lentiviral encephalitis
SJ Bissel, G Wang, AM Trichel, M Murphey-Corb, CA Wiley |
The American Journal of Pathology | 2006 |
Natalizumab: a promising treatment for Crohn’s disease
JF Colombel, L Peyrin-Biroulet |
Expert Review of Clinical Immunology | 2006 |
Integrin alpha 4
M Mittelbrunn, C Cabanas, F Sanchez-Madrid |
AfCS-Nature Molecule Pages | 2006 |
Multiple sclerosis, natalizumab therapy, and progressive multifocal leukoencephalopathy
RE Bartt |
Current Opinion in Neurology | 2006 |
INTESTINAL AND PULMONARY MUCOSAL T CELLS: Local Heroes Fight to Maintain the Status Quo
L Lefrançois, L Puddington |
Annual Review of Immunology | 2006 |
Natalizumab plus Interferon Beta-1a for Relapsing Multiple Sclerosis
RA Rudick, WH Stuart, PA Calabresi, C Confavreux, SL Galetta, EW Radue, FD Lublin, B Weinstock-Guttman, DR Wynn, F Lynn, MA Panzara, AW Sandrock |
New England Journal of Medicine | 2006 |
New approaches to blockade of α4-integrins, proven therapeutic targets in chronic inflammation
C Kummer, MH Ginsberg |
Biochemical Pharmacology | 2006 |
Lack of α4 integrin expression in stem cells restricts competitive function and self-renewal activity
GV Priestley, LM Scott, T Ulyanova, T Papayannopoulou |
Blood | 2006 |
Blockade von Adhäsionsmolekülen mit Natalizumab in der Therapie der Multiplen Sklerose: Aktueller Studienstand
B Schreiner, BC Kieseier, HP Hartung, R Hohlfeld, H Wiendl |
Der Nervenarzt | 2005 |
Therapeutic anti-integrin (α4 and αL) monoclonal antibodies: two-edged swords?
R González-Amaro, M Mittelbrunn, F Sánchez-Madrid |
Immunology | 2005 |
PDE4 inhibitors as new anti-inflammatory drugs: Effects on cell trafficking and cell adhesion molecules expression
MJ Sanz, J Cortijo, EJ Morcillo |
Pharmacology & Therapeutics | 2005 |
Blockade von Adhäsionsmolekülen mit Natalizumab in der Therapie der Multiplen Sklerose
B Schreiner, BC Kieseier, HP Hartung, R Hohlfeld, H Wiendl |
Der Nervenarzt | 2005 |
The role of osteopontin in foreign body giant cell formation
AT Tsai, J Rice, M Scatena, L Liaw, BD Ratner, CM Giachelli |
Biomaterials | 2005 |
Involvement of α4 integrins in maintenance of cardiac sympathetic axons
KL Wingerd, WC Wayne, DY Jackson, DO Clegg |
Autonomic Neuroscience | 2005 |
NeuroImmune Biology
R Solana, G Pawelec |
NeuroImmune Biology | 2005 |
A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity
J Gläsner, H Blum, V Wehner, HU Stilz, JD Humphries, GP Curley, AP Mould, MJ Humphries, R Hallmann, M Röllinghoff, A Gessner |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Natalizumab for the Treatment of Multiple Sclerosis and Crohn's Disease
KA Keeley, MP Rivey, DR Allington |
The Annals of pharmacotherapy | 2005 |
The Expression of α4 Integrins by Human Polymorphonuclear Neutrophils in Response to Sonicated Extracts of Enterococcus faecalis
W Shon, S Lim, K Bae, S Baek, W Lee |
Journal of Endodontics | 2005 |
Inflammatory Bowel Disease: Translation from Basic Research to Clinical Practice
, J Schölmerich, C Gasché, B Vucelic |
2005 | |
Influence of β 1 Integrin Intracytoplasmic Domains in the Regulation of VLA-4-Mediated Adhesion of Human T Cells to VCAM-1 under Flow Conditions
MA Rosenthal-Allieri, M Ticchioni, JP Breittmayer, Y Shimizu, A Bernard |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Antisense oligonucleotide blockade of alpha 4 integrin prevents and reverses clinical symptoms in murine experimental autoimmune encephalomyelitis
KJ Myers, DR Witchell, MJ Graham, S Koo, M Butler, TP Condon |
Journal of Neuroimmunology | 2004 |
VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses
M Mittelbrunn, A Molina, MM Escribese, M Yáñez-Mó, E Escudero, A Ursa, R Tejedor, F Mampaso, F Sánchez-Madrid |
Proceedings of the National Academy of Sciences | 2004 |
Expression and function of integrin ?4?1 and vascular cell adhesion molecule-1 (VCAM-1) during sympathetic innervation of the heart
KL Wingerd, NL Goodman, ST Leu, DO Clegg |
Developmental Dynamics | 2004 |
Integrin α4β1 function is required for cell survival in developing retina
ST Leu, SA Jacques, KL Wingerd, ST Hikita, EC Tolhurst, JL Pring, D Wiswell, L Kinney, NL Goodman, DY Jackson, DO Clegg |
Developmental Biology | 2004 |
A Monoclonal Antibody to α1β1 Blocks Antigen-induced Airway Responses in Sheep
WM Abraham, A Ahmed, I Serebriakov, AN Carmillo, J Ferrant, AR de Fougerolles, EA Garber, PJ Gotwals, VE Koteliansky, F Taylor, RR Lobb |
American journal of respiratory and critical care medicine | 2004 |
Antagonism of the α4 integrin subunit attenuates the acute inflammatory response to stent implantation yet is insufficient to prevent late intimal formation
X Ma, ER O'Brien |
Journal of leukocyte biology | 2004 |
Aberrant methylation of integrin α4 gene in human gastric cancer cells
J Park, SH Song, TY Kim, MC Choi, HS Jong, TY Kim, JW Lee, NK Kim, WH Kim, YJ Bang |
Oncogene | 2004 |
Adhesion capacity and integrin expression by dendritic-like cells generated from acute myeloid leukemia blasts by calcium ionophore treatment
E Sadovnikova, EN Parovichnikova, EL Semikina, EA Kopiltsova, DA Svinareva, VM Belkin, NA Torubarova, VG Savchenko |
Experimental Hematology | 2004 |
Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention
WG Jiang, RE Mansel |
2004 | |
EWI-2 modulates lymphocyte integrin α4β1 functions
TV Kolesnikova, CS Stipp, RM Rao, WS Lane, FW Luscinskas, ME Hemler |
Blood | 2004 |
Design, Synthesis, and Analysis of a Polyethelene Glycol-Modified (PEGylated) Small Molecule Inhibitor of Integrin α4β1 with Improved Pharmaceutical Properties
RB Pepinsky, WC Lee, M Cornebise, A Gill, K Wortham, LL Chen, DR Leone, K Giza, BM Dolinski, S Perper, C Nickerson-Nutter, D Lepage, A Chakraborty, ET Whalley, RC Petter, SP Adams, RR Lobb, DM Scott |
The Journal of pharmacology and experimental therapeutics | 2004 |
Characterization of Lewis lung clonal variants in a model of syngeneic pulmonary murine metastases
BT Storey, JF Christian |
Clinical & Experimental Metastasis | 2004 |
An Assessment of the Mechanistic Differences Between Two Integrin α 4 β 1 Inhibitors, the Monoclonal Antibody TA-2 and the Small Molecule BIO5192, in Rat Experimental Autoimmune Encephalomyelitis
DR Leone, K Giza, A Gill, BM Dolinski, W Yang, S Perper, DM Scott, WC Lee, M Cornebise, K Wortham, C Nickerson-Nutter, LL Chen, D LePage, JC Spell, ET Whalley, RC Petter, SP Adams, RR Lobb, RB Pepinsky |
The Journal of pharmacology and experimental therapeutics | 2003 |
Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrin
WJ Sandborn, TA Yednock |
The American Journal of Gastroenterology | 2003 |
Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage
E Bergeron, A Basak, E Decroly, NG Seidah |
Biochemical Journal | 2003 |
Integrin α4β1 (VLA-4) expression and activity in retinal and peripheral neurons
ST Hikita, GM Cann, KL Wingerd, LH Mullick, WC Wayne, SW Webb, DO Clegg |
Molecular and Cellular Neuroscience | 2003 |
Immunosuppressive effects of a Kv1.3 inhibitor
K Shah, JT Blake, C Huang, P Fischer, GC Koo |
Cellular Immunology | 2003 |
Natalizumab for Active Crohn's Disease
S Ghosh, E Goldin, FH Gordon, HA Malchow, J Rask-Madsen, P Rutgeerts, P Vyhnálek, Z Zádorová, T Palmer, S Donoghue |
New England Journal of Medicine | 2003 |
Functional antibodies to leukocyte adhesion molecules in antithymocyte globulins1:
MC Michallet, X Preville, M Flacher, S Fournel, L Genestier, JP Revillard |
Transplantation | 2003 |
A Small Molecule Very Late Antigen–4 Antagonist Can Inhibit Ovalbumin-induced Lung Inflammation
GC Koo, K Shah, GJ Ding, J Xiao, R Wnek, G Doherty, XC Tong, RB Pepinsky, KC Lin, WK Hagmann, D Kawka, II Singer |
American journal of respiratory and critical care medicine | 2003 |
A broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model
A Iwata, K Nishio, RK Winn, EY Chi, WR Henderson, JM Harlan |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Of Mice and Men
WM Abraham |
American journal of respiratory cell and molecular biology | 2003 |
Role of Monocytes in Atherogenesis
B Østerud, E Bjørklid |
Physiological reviews | 2003 |
Rapid Up-Regulation of α4 Integrin-mediated Leukocyte Adhesion by Transforming Growth Factor-β1
RA Bartolomé, F Sanz-Rodrı́guez, MM Robledo, A Hidalgo, J Teixidó, CH Heldin |
Molecular biology of the cell | 2003 |
Intrabody and intrakine strategies for molecular therapy
YY Wheeler, SY Chen, DC Sane |
Molecular Therapy | 2003 |
Blockade of integrin VLA-4 prevents inflammation and matrix metalloproteinase expression in a murine model of accelerated collagen-induced arthritis
Anil Raychaudhuri, Mary Chou, Marla Weetall, Arco Y Jeng |
Inflammation | 2003 |
Very late antigen-4 in CD18-independent neutrophil emigration during acute bacterial pneumonia in mice
S Tasaka, SE Richer, JP Mizgerd, CM Doerschuk |
American journal of respiratory and critical care medicine | 2002 |
alpha4 integrins and the immune response
DM Rose, J Han, MH Ginsberg |
Immunological Reviews | 2002 |
Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation
GJ Bellingan, P Xu, H Cooksley, H Cauldwell, A Shock, S Bottoms, C Haslett, SE Mutsaers, GJ Laurent |
Journal of Experimental Medicine | 2002 |
Adhesion of osteosarcoma cells to the 70-kDa core region of thrombospondin-1 is mediated by the α4β1 integrin
S Decker, F Valen, P Vischer |
Biochemical and Biophysical Research Communications | 2002 |
Inhibitors of Cell Migration that Inhibit Intracellular Paxillin/α4 Binding
Y Ambroise, B Yaspan, MH Ginsberg, DL Boger |
Chemistry & Biology | 2002 |
Clinical overview of leukocyte adhesion and migration: where are we now?
D Marshall, DO Haskard |
Seminars in Immunology | 2002 |
The discovery of small molecule carbamates as potent dual α4β1/α4β7 integrin antagonists
LL Chang, Q Truong, RA Mumford, LA Egger, U Kidambi, K Lyons, E McCauley, GV Riper, S Vincent, JA Schmidt, M MacCoss, WK Hagmann |
Bioorganic & Medicinal Chemistry Letters | 2002 |
Methods in Cell Biology
JW Smith |
Methods in cell biology | 2002 |
Adenosine Suppresses α4β7 Integrin-Mediated Adhesion of T Lymphocytes to Colon Adenocarcinoma Cells
WM MacKenzie, DW Hoskin, J Blay |
Experimental Cell Research | 2002 |
Mechanisms for sickle red blood cell retention in choroid
GA Lutty, T Otsuji, M Taomoto, C Merges, DS McLeod, SY Kim, P Vanderslice, S Suzuka, ME Fabry, RL Nagel |
Current Eye Research | 2002 |
Adhesion Molecule–dependent Mechanisms Regulate the Rate of Macrophage Clearance During the Resolution of Peritoneal Inflammation
GJ Bellingan, P Xu, H Cooksley, H Cauldwell, A Shock, S Bottoms, C Haslett, SE Mutsaers, GJ Laurent |
Journal of Experimental Medicine | 2002 |
Effects of VLA-4 antagonists in rat whole embryo culture
S Spence, C Vetter, WK Hagmann, GV Riper, H Williams, RA Mumford, TJ Lanza, LS Lin, JA Schmidt |
Teratology | 2002 |
Alpha 4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart
Kevin L Wingerd, Nichol L Goodman, Jason W Tresser, Matthew M Smail, Sergiu T Leu, Steven J Rohan, Jan L Pring, David Y Jackson, Dennis O Clegg |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2002 |
Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas
I Lewis, B Rohde, M Mengus, M Weetall, S Maida, R Hugo, P Lake |
Molecular Diversity | 2002 |
α4 Integrins and Vascular Cell Adhesion Molecule-1 Play a Role in Sympathetic Innervation of the Heart
Wingerd KL, Goodman NL, Tresser JW, Smail MM, Leu ST, Rohan SJ, Pring JL, Jackson DY, Clegg DO |
Journal of Neuroscience | 2002 |
Encephalitogenic lymphoblast recruitment to resting central nerve system microvasculature: a natural immunosurveillance mechanism?
Ronen Alon |
Journal of Clinical Investigation | 2001 |
VLA-4-Dependent Myeloma Cell Adhesion
F Sanz-rodríguez, J Teixidó |
Leukemia & Lymphoma | 2001 |
Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells
A Hidalgo, F Sanz-Rodrı́guez, JL Rodrı́guez-Fernández, B Albella, C Blaya, N Wright, C Cabañas, F Prósper, JC Gutierrez-Ramos, J Teixidó |
Experimental Hematology | 2001 |
The use of one-bead one-compound combinatorial library method to identify peptide ligands for α4β1 integrin receptor in non-Hodgkin's lymphoma
SI Park, M Renil, B Vikstrom, N Amro, L Song, B Xu, KS Lam |
Letters in Peptide Science | 2001 |
A Homogeneous Fluorometric Assay for Measuring Cell Adhesion to Immobilized Ligand Using V-Well Microtiter Plates
M Weetall, R Hugo, S Maida, S West, S Wattanasin, R Bouhel, G Weitz-Schmidt, P Lake, C Friedman |
Analytical Biochemistry | 2001 |
Structural elements of the osteopontin SVVYGLR motif important for the interaction with α4 integrins
PM Green, SB Ludbrook, DD Miller, CM Horgan, ST Barry |
FEBS Letters | 2001 |
Beneficial effect of modified peptide inhibitor of α4 integrins on experimental allergic encephalomyelitis in Lewis rats: α4 Integrin Inhibitors Suppress EAE
LJ van der Laan, A der Goes, MH Wauben, SR Ruuls, EA Döpp, CJ de Groot, TW Kuijpers, MJ Elices, CD Dijkstra |
Journal of Neuroscience Research | 2001 |
An altered peptide ligand inhibits the activities of matrix metalloproteinase-9 and phospholipase C, and inhibits T cell interactions with VCAM-1 induced in vivo by a myasthenogenic T cell epitope
A Faber-Elmann, V Grabovsky, M Dayan, M Sela, R Alon, E Mozes |
The FASEB Journal | 2001 |
Evidence That Ligand and Metal Ion Binding to Integrin α 4 β 1 Are Regulated through a Coupled Equilibrium
LL Chen, A Whitty, D Scott, WC Lee, M Cornebise, SP Adams, RC Petter, RR Lobb, RB Pepinsky |
The Journal of biological chemistry | 2001 |
Identification of Dual α 4 β 1 Integrin Binding Sites within a 38 Amino Acid Domain in the N-terminal Thrombin Fragment of Human Osteopontin
KJ Bayless, GE Davis |
The Journal of biological chemistry | 2001 |
Central role of the ?4?1 integrin in the coordination of avian truncal neural crest cell adhesion, migration, and survival
S Testaz, JL Duband |
Developmental Dynamics | 2001 |
Inhibition of α4 Integrin Protects Against Transient Focal Cerebral Ischemia in Normotensive and Hypertensive Rats
JK Relton, KE Sloan, EM Frew, ET Whalley, SP Adams, RR Lobb |
Stroke; a journal of cerebral circulation | 2001 |
Peptides: The Wave of the Future: Proceedings of the Second International and the Seventeenth American Peptide Symposium, June 9–14, 2001, San Diego, California, U.S.A
M Lebl, RA Houghten |
2001 | |
Biotechnology Set
HJ Rehm, G Reed |
2001 | |
Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1
F Sanz-Rodrı́guez, A Hidalgo, J Teixidó |
Blood | 2001 |
In Situ Activation of Helper T Cells in the Lung
RN Moore, B Raju, CF Tung, D Cheng, N Yousefzadeh, R Condos, WN Rom, DB Tse |
Infection and immunity | 2001 |
A CD2-Green Fluorescence Protein-Transgenic Mouse Reveals Very Late Antigen-4-Dependent CD8 + Lymphocyte Rolling in Inflamed Venules
K Singbartl, J Thatte, ML Smith, K Wethmar, K Day, K Ley |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Leukocyte integrin expression in patients undergoing cardiopulmonary bypass
G Asimakopoulos, A Kohn, DC Stefanou, DO Haskard, RC Landis, KM Taylor |
The Annals of Thoracic Surgery | 2000 |
Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice
S Sarnacki, F Auber, C Crétolle, C Camby, M Cavazzana-Calvo, W Müller, N Wagner, N Brousse, Y Révillon, A Fischer, N Cerf-Bensussan |
Gut | 2000 |
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
V Grabovsky, S Feigelson, C Chen, DA Bleijs, A Peled, G Cinamon, F Baleux, F Arenzana-Seisdedos, T Lapidot, K Y, RR Lobb, R Alon |
Journal of Experimental Medicine | 2000 |
Subsecond Induction of 4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions
V Grabovsky, S Feigelson, C Chen, DA Bleijs, A Peled, G Cinamon, F Baleux, F Arenzana-Seisdedos, T Lapidot, Y Kooyk, RR Lobb, R Alon |
Journal of Experimental Medicine | 2000 |
Novel Roles for Integrins in the Nervous System
DO Clegg |
Molecular Cell Biology Research Communications | 2000 |
Production of recombinant soluble human integrin α4β1
K Clark, P Newham, L Burrows, JA Askari, MJ Humphries |
FEBS Letters | 2000 |
Effect of antibody against integrin alpha4 on bleomycin-induced pulmonary fibrosis in mice
Q Wang, Y Wang, DM Hyde, PJ Gotwals, RR Lobb, ST Ryan, SN Giri |
Biochemical Pharmacology | 2000 |
Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice
A Kanehiro, K Takeda, A Joetham, A Tomkinson, T Ikemura, CG Irvin, EW Gelfand |
American journal of respiratory and critical care medicine | 2000 |
The Adhesion Molecule FactsBook
CM Isacke, MA Horton |
The Adhesion Molecule FactsBook | 2000 |
A Small-Molecule, Tight-binding Inhibitor of the Integrin α 4 β 1 Blocks Antigen-induced Airway Responses and Inflammation in Experimental Asthma in Sheep
WM Abraham, A Gill, A Ahmed, MW Sielczak, IT Lauredo, Y Botinnikova, KC Lin, B Pepinsky, DR Leone, RR Lobb, SP Adams |
American journal of respiratory and critical care medicine | 2000 |
Analysis of the α4β1 Integrin–Osteopontin Interaction
ST Barry, SB Ludbrook, E Murrison, CM Horgan |
Experimental Cell Research | 2000 |
The role of α4 and LFA-1 integrins in selectin-independent monocyte and neutrophil migration to joints of rats with adjuvant arthritis
U Birner, TB Issekutz, U Walter, AC Issekutz |
International Immunology | 2000 |
The α 4 Integrin Subunit Tyr 187 Has a Key Role in α 4 β 7 -Dependent Cell Adhesion
N Ruiz-Velasco, M Guerrero-Esteo, MJ Briskin, J Teixidó |
The Journal of biological chemistry | 2000 |
Novel Therapeutic Proteins: Selected Case Studies
K Dembowsky, P Stadler |
2000 | |
Cell adhesion receptors in lymphoma dissemination
P Drillenburg, ST Pals |
Blood | 2000 |
The parting of the endothelium: miracle, or simply a junctional affair?
C Johnson-Leger, M Aurrand-Lions, BA Imhof |
Journal of cell science | 2000 |
Potent Costimulation of Effector T Lymphocytes by Human Collagen Type I
WH Rao, JM Hales, RD Camp |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Up-Regulation of VCAM-1 and Differential Expansion of β Integrin-Expressing T Lymphocytes Are Associated with Immunity to Pulmonary Mycobacterium tuberculosis Infection
CG Feng, WJ Britton, U Palendira, NL Groat, H Briscoe, AG Bean |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Maturation-Dependent Expression and Function of the CD49d Integrin on Monocyte-Derived Human Dendritic Cells
A Puig-Kröger, F Sanz-Rodríguez, N Longo, P Sánchez-Mateos, L Botella, J Teixidó, C Bernabéu, AL Corbí |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
In Vivo Roles of Integrins During Leukocyte Development and Traffic: Insights from the Analysis of Mice Chimeric for α 5 , α v , and α 4 Integrins
AG Arroyo, D Taverna, CA Whittaker, UG Strauch, BL Bader, H Rayburn, D Crowley, CM Parker, RO Hynes |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
A novel RGD-independent fibronectin assembly pathway initiated by alpha4beta1 integrin binding to the alternatively spliced V region
JL Sechler, AM Cumiskey, DM Gazzola, JE Schwarzbauer |
Journal of cell science | 2000 |
Expression of Mucosal Homing Receptor α4β7 Is Associated with Enhanced Migration to the Chlamydia -Infected Murine Genital Mucosa In Vivo
JD Clements, RA Hawkins, RG Rank, KA Kelly |
Infection and immunity | 2000 |
VCAM-1 has a tissue-specific role in mediating interleukin-4–induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration
KY Larbi, AR Allen, FW Tam, DO Haskard, RR Lobb, PM Silva, S Nourshargh |
Blood | 2000 |
Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating β1 integrin
PT Shih, MJ Elices, ZT Fang, TP Ugarova, D Strahl, MC Territo, JS Frank, NL Kovach, C Cabanas, JA Berliner, DK Vora |
Journal of Clinical Investigation | 1999 |
Erythroid cell adhesion molecules Lutheran and LW in health and disease
SF Parsons, FA Spring, JA Chasis, DJ Anstee |
Best Practice & Research Clinical Haematology | 1999 |
Peptide and peptidomimetic inhibitors of VLA-4
CN Zimmerman |
Expert Opinion on Therapeutic Patents | 1999 |
Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of alpha4 integrins and vascular cell adhesion molecule-1
K Nagai, S Larkin, A Hartnell, K Larbi, MR Aghakhani, C Windley, D Davies, RR Lobb, TJ Williams, S Nourshargh |
Immunology | 1999 |
VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin
D Davies, K Larbi, A Allen, M Sanz, VB Weg, DO Haskard, RR Lobb, S Nourshargh |
Immunology | 1999 |
Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus
JR Silva, C Ruffié, J Lefort, MA Nahori, BB Vargaftig, M Pretolani |
Mediators of Inflammation | 1999 |
Independent repressor domains in ZEB regulate muscle and T-cell differentiation
AA Postigo, DC Dean |
Molecular and cellular biology | 1999 |
Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression?
U Syrbe, J Siveke, A Hamann |
Springer Seminars in Immunopathology | 1999 |
α4 Integrins Regulate the Proliferation/Differentiation Balance of Multilineage Hematopoietic Progenitors In Vivo
AG Arroyo, JT Yang, H Rayburn, RO Hynes |
Immunity | 1999 |
Small molecule antagonists of α4 integrins: novel drugs for asthma
RR Lobb, SP Adams |
Expert Opinion on Investigational Drugs | 1999 |
The α4-integrin: an alternative pathway for neutrophil recruitment?
B Johnston, P Kubes |
Immunology Today | 1999 |
alpha4 integrin-dependent eotaxin induction of bronchial hyperresponsiveness and eosinophil migration in interleukin-5 transgenic mice
T Hisada, PG Hellewell, MM Teixeira, MG Malm, M Salmon, TJ Huang, KF Chung |
American journal of respiratory cell and molecular biology | 1999 |
Homing of human cells in the fetal sheep model: modulation by antibodies activating or inhibiting very late activation antigen-4-dependent function
E D Zanjani, A W Flake, G Almeida-Porada, N Tran, T Papayannopoulou |
Journal of Clinical Investigation | 1999 |
Multiple Activation States of Integrin α 4 β 1 Detected through Their Different Affinities for a Small Molecule Ligand
LL Chen, A Whitty, RR Lobb, SP Adams, RB Pepinsky |
The Journal of biological chemistry | 1999 |
EC3, a Novel Heterodimeric Disintegrin from Echis carinatus Venom, Inhibits α4 and α5 Integrins in an RGD-independent Manner
C Marcinkiewicz, JJ Calvete, MM Marcinkiewicz, M Raida, S Vijay-Kumar, Z Huang, RR Lobb, S Niewiarowski |
The Journal of biological chemistry | 1999 |
Total Synthesis of HUN-7293
DL Boger, H Keim, B Oberhauser, EP Schreiner, CA Foster |
Journal of the American Chemical Society | 1999 |
Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents
KC Lin, AC Castro |
Current Opinion in Chemical Biology | 1998 |
Expression of alpha5 (CD49e) and alpha6 (CD49f) Integrin Subunits on T Cells in the Circulation and the Lamina Propria of Normal and Inflammatory Bowel Disease Colonic Mucosa
Pilling, Galvin, Robins, Sewell, Mahida |
Scandinavian Journal of Immunology | 1998 |
T cell interaction with ICAM-1-deficient endotheliumin vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells
Y Reiss, G Hoch, U Deutsch, B Engelhardt |
European Journal of Immunology | 1998 |
Role of two conserved glycine residues in the β-propeller domain of the integrin α4 subunit in VLA-4 conformation and function
M Guerrero-Esteo, N Ruiz-Velasco, M Muñoz, J Teixidó |
FEBS Letters | 1998 |
Involvement of Intercellular Adhesion Molecule-1 in the Antigen-induced Infiltration of Eosinophils and Lymphocytes into the Airways in a Murine Model of Pulmonary Inflammation
JE Chin, GE Winterrowd, CA Hatfield, JR Brashler, RL Griffin, SL Vonderfecht, KP Kolbasa, SF Fidler, KL Shull, RF Krzesicki, KA Ready, CJ Dunn, LM Sly, ND Staite, IM Richards |
American journal of respiratory cell and molecular biology | 1998 |
Encyclopedia of Immunology
RL Riley |
Encyclopedia of Immunology | 1998 |
Biotechnology: A: Recombinant Proteins, Monoclonal Antibodies, and Therapeutic Genes
HJ Rehm, G Reed |
1998 | |
Neuroinflammation
PL Wood |
Neuroinflammation | 1998 |
Leukocyte Integrins in the Immune System and Malignant Disease
B Holzmann, H Wagner |
1998 | |
Osteopontin is a ligand for the alpha4beta1 integrin
KJ Bayless, GA Meininger, JM Scholtz, GE Davis |
Journal of cell science | 1998 |
Anti–VLA4/VCAM-1—Induced Mobilization Requires Cooperative Signaling Through the kit/mkit Ligand Pathway
T Papayannopoulou, GV Priestley, B Nakamoto |
Blood | 1998 |
Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways
AD Fryer, RW Costello, BL Yost, RR Lobb, TF Tedder, DA Steeber, BS Bochner |
Journal of Clinical Investigation | 1997 |
Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma
WR Henderson, EY Chi, RK Albert, SJ Chu, WJ Lamm, Y Rochon, M Jonas, PE Christie, JM Harlan |
Journal of Clinical Investigation | 1997 |
Adhesion molecules. A rheumatologic perspective
CF Mojcik, EM Shevach |
Arthritis & Rheumatism | 1997 |
c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB
AA Postigo, AM Sheppard, ML Mucenski, DC Dean |
The EMBO Journal | 1997 |
ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation
AA Postigo, DC Dean |
The EMBO Journal | 1997 |
Beta 2 (CD18) and beta 1 (CD29) integrin mechanisms in migration of human polymorphonuclear leucocytes and monocytes through lung fibroblast barriers: shared and distinct mechanisms
XZ Shang, AC Issekutz |
Immunology | 1997 |
The beta 1 integrin, very late activation antigen-4 on human neutrophils can contribute to neutrophil migration through connective tissue fibroblast barriers
JX Gao, AC Issekutz |
Immunology | 1997 |
A novel region of the alpha4 integrin subunit with a modulatory role in VLA-4-mediated cell adhesion to fibronectin
M Muñoz, J Serrador, M Nieto, A Luque, F Sánchez-Madrid, J Teixidó |
Biochemical Journal | 1997 |
Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts
AJ Coito, LF Brown, JH Peters, JW Kupiec-Weglinski, L de Water |
The American Journal of Pathology | 1997 |
Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1)
Q Yuan, KF Austen, DS Friend, M Heidtman, JA Boyce |
Journal of Experimental Medicine | 1997 |
Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatis
KA Kelly, RG Rank |
Infection and immunity | 1997 |
Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein
H Valentin, I Lemasson, S Hamaia, H Cassé, S König, C Devaux, L Gazzolo |
Journal of virology | 1997 |
Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1
A Irie, T Kamata, Y Takada |
Proceedings of the National Academy of Sciences | 1997 |
Alpha 4 beta 7 integrin expression is associated with the leukemic evolution of human and murine T-cell lymphoblastic lymphomas
R Dolcetti, R Giardini, C Doglioni, R Cariati, F Pomponi, C D'Orazi, S Rao, AI Lazarovits, EC Butcher, M Boiocchi |
The American Journal of Pathology | 1997 |
Activation status and function of the VLA-4 (α4β1) integrin expressed on human melanoma cell lines
A Saini, Z Seller, D Davies, JF Marshall, IR Hart |
International Journal of Cancer | 1997 |
Therapy with antibody against leukocyte integrin VLA-4 (CD49d) is effective and safe in virus-facilitated experimental allergic encephalomyelitis
M Soilu-Hänninen, M Röyttä, A Salmi, R Salonen |
Journal of Neuroimmunology | 1997 |
Human Peripheral Blood Eosinophils Express a Functional c-kit Receptor for Stem Cell Factor that Stimulates Very Late Antigen 4 (VLA-4)-mediated Cell Adhesion to Fibronectin and Vascular Cell Adhesion Molecule 1 (VCAM-1)
Q Yuan, KF Austen, DS Friend, M Heidtman, JA Boyce |
Journal of Experimental Medicine | 1997 |
Advances in Molecular and Cell Biology
KJ Clemetson |
Advances in Molecular and Cell Biology | 1997 |
The Leucocyte Antigen FactsBook
AN Barclay, MH Brown, SK Law, AJ McKnight, MG Tomlinson, PA van der Merwe |
The Leucocyte Antigen FactsBook | 1997 |
Multiple loop structures critical for ligand binding of the integrin 4 subunit in the upper face of the -propeller mode 1
A Irie, T Kamata, Y Takada |
Proceedings of the National Academy of Sciences | 1997 |
The role of platelets in the early and late vascular responses initiated by mechanical vascular injury
LA Harker |
Fibrinolysis and Proteolysis | 1997 |
Adhesion molecules as determinants of disease: From molecular biology to surgical research
MD Menger, B Vollmar |
British Journal of Surgery | 1996 |
VCAM-1/α4-integrin adhesion pathway: Therapeutic target for allergic inflammatory disorders
CA Foster |
Journal of Allergy and Clinical Immunology | 1996 |
Pathophysiologic Role of ?4 Integrins in the Lung
RR Lobb, WM Abraham, LC Burkly, A Gill, W Ma, JA Knight, DR Leone, G Antognetti, RB Pepinsky |
Annals of the New York Academy of Sciences | 1996 |
Adhesion Molecules-Their Role in Health and Disease
A Etzioni |
Pediatric Research | 1996 |
The α4β1 Fibronectin Ligands CS-19 HEP II, and RGD Induce Different Intracellular Events in B Lymphoid Cells. Comparison with the Effects of the Endothelial Ligand V CAM-1
C Domínguez-Jimenez, P Sánchez-Aparicio, JP Albarb, A García-Pardoa |
Cell Communication and Adhesion | 1996 |
Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis
C Weber, R Alon, B Moser, TA Springer |
The Journal of Cell Biology | 1996 |
Intracellular single-chain antibody inhibits integrin VLA-4 maturation and function
Q Yuan, KL Strauch, RR Lobb, ME Hemler |
Biochemical Journal | 1996 |
Predominant role of alpha 4-integrins for distinct steps of lymphoma metastasis
U Gosslar, P Jonas, A Luz, A Lifka, D Naor, A Hamann, B Holzmann |
Proceedings of the National Academy of Sciences | 1996 |
The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo
B Johnston, TB Issekutz, P Kubes |
Journal of Experimental Medicine | 1996 |
Expression of VCAM-1 and VLA-4 dependent T-lymphocyte adhesion to dermal fibroblasts stimulated with proinflammatory cytokines
JX Gao, AC Issekutz |
Immunology | 1996 |
Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation
C Pujades, J Teixidó, G Bazzoni, ME Hemler |
Biochemical Journal | 1996 |
Essentials of Mucosal Immunology
DK Podolsky |
Essentials of Mucosal Immunology | 1996 |
Therapeutic Effects of Antibodies Against Adhesion Molecules in Murine Collagen Type II-Induced Arthritis
A Zeidler, R Bräuer, K Thoss, J Bahnsen, V Heinrichs, D Jablonski-Westrich, M Wroblewski, S Rebstock, A Hamann |
Autoimmunity | 1995 |
Adhesion molecules in health and disease
RJ Faull |
Australian and New Zealand Journal of Medicine | 1995 |
Vascular Cell Adhesion Molecule (VCAM)-Ig Fusion Protein Defines Distinct Affinity States of the Very Late Antigen-4 (VLA-4) Receptor
A Jakubowski, MD Rosa, S Bixler, R Lobb, LC Burkly |
Cell Communication and Adhesion | 1995 |
Biologic therapy for inflammatory bowel disease
BE Sands |
Inflammatory Bowel Diseases | |
Fatalities in natalizumab treatment - a 'no go for leukocyte recirculation approaches?
YY Li, HD Perez, TM Zollner |
Expert Opinion on Therapeutic Targets | 2006 |
A Direct Binding Assay for the Vascular Cell Adhesion Molecule-1 (VCAM1) Interaction with α4 Integrins
RR Lobb, G Antognetti, RB Pepinsky, LC Burkly, DR Leone, A Whitty |
Cell Communication and Adhesion | 1995 |
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
R Alon, PD Kassner, MW Carr, EB Finger, ME Hemler, TA Springer |
The Journal of Cell Biology | 1995 |
Extracellular matrix proteins, regulators of T-cell functions in healthy and diseased individuals
A Gorski, JW Kupiec-Weglinski |
Clinical and diagnostic laboratory immunology | 1995 |
Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits
A Irie, T Kamata, W Puzon-McLaughlin, Y Takada |
The EMBO Journal | 1995 |
Determinant-Regulated Onset of Experimental Autoimmune Encephalomyelitis: Distinct Epitopes of Myelin Proteolipid Protein Mediate Either Acute or Delayed Disease in SJL/J Mice
VK Tuohy, DM Thomas, T Haqqi, M Yu, JM Johnson |
Autoimmunity | 1995 |
Molecular and cellular interactions mediating granulocyteaccumulation in vivo
S Nourshargh, TJ Williams |
Seminars in Cell Biology | 1995 |
Biologic Therapy for Inflammatory Bowel Disease:
BE Sands |
Inflammatory Bowel Diseases | |
Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet
PT Shih, ML Brennan, DK Vora, MC Territo, D Strahl, MJ Elices, AJ Lusis, JA Berliner |
Circulation research | 1999 |
Fibronectin: structure, assembly, and cardiovascular implications
MK Magnusson, DF Mosher |
Arteriosclerosis, thrombosis, and vascular biology | 1998 |
Blockade of Late-phase Airway Responses and Airway Hyperresponsiveness in Allergic Sheep with a Small-molecule Peptide Inhibitor of VLA-4
WM Abraham, A Ahmed, MW Sielczak, M Narita, T Arrhenius, MJ Elices |
American journal of respiratory and critical care medicine | 1997 |
VLA-4-Mediated Interactions Between Normal Human Hematopoietic Progenitors and Stromal Cells
RA Oostendorp, P Dörmer |
Leukemia & Lymphoma | 1997 |
Role of Cell Adhesion Molecules in Inflammatory Bowel Diseases
B Vainer |
Scandinavian Journal of Gastroenterology | 1997 |
Cross Talk between Adhesion Molecules: Control of N-cadherin Activity by Intracellular Signals Elicited by β1 and β3 Integrins in Migrating Neural Crest Cells
F Monier-Gavelle, JL Duband |
The Journal of Cell Biology | 1997 |
Generation of Monoclonal Antibodies to Integrin-associated Proteins: EVIDENCE THAT α 3 β 1 COMPLEXES WITH EMMPRIN/BASIGIN/OX47/M6
F Berditchevski, S Chang, J Bodorova, ME Hemler |
The Journal of biological chemistry | 1997 |
Defining Extracellular Integrin α-Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding
C Pujades, R Alon, RL Yauch, A Masumoto, LC Burkly, C Chen, TA Springer, RR Lobb, ME Hemler |
Molecular biology of the cell | 1997 |
Forschung in der Chirurgie
HG Berger, A Schwarz, UB Brückner, W Hartel |
1997 | |
Tumor Necrosis Factor α-Induced Eosinophil Accumulation in Rat Skin Is Dependent on α4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways
MJ Sanz, A Hartnell, P Chisholm, C Williams, D Davies, VB Weg, M Feldmann, MA Bolanowski, RR Lobb, S Nourshargh |
Blood | 1997 |
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1): Its binding motif for α4β7 and role in experimental colitis
S Fong, S Jones, ME Renz, HH Chiu, AM Ryan, LG Presta, D Jackson |
Immunologic Research | 1997 |
Molecular Cloning and Expression of the Gene for Elastin-binding Protein ( ebpS ) in Staphylococcus aureus
PW Park, J Rosenbloom, WR Abrams, J Rosenbloom, RP Mecham |
The Journal of biological chemistry | 1996 |
Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo
D Raeburn, MA Giembycz |
1996 | |
Attempts to Understand Metastasis Formation II
U Günthert, W Birchmeier |
1996 | |
A Region of the Integrin VLAα4 Subunit Involved in Homotypic Cell Aggregation and in Fibronectin but Not Vascular Cell Adhesion Molecule-1 Binding
M Muñoz, J Serrador, F Sánchez-Madrid, J Teixidó |
The Journal of biological chemistry | 1996 |
Differential Regulation of Integrin-dependent Binding to Domains 1 and 4 of Vascular Cell Adhesion Molecule-1
G Kilger, LA Needham, PJ Nielsen, J Clements, D Vestweber, B Holzmann |
The Journal of biological chemistry | 1995 |
Molecular mapping of functional antibody binding sites of α4
SG Schiffer, ME Hemler, RR Lobb, R Tizard, L Osborn |
The Journal of biological chemistry | 1995 |
Molecular analysis of the physiological and pathophysiological role of ?4-integrins
G Kilger, B Holzmann |
Journal of Molecular Medicine | 1995 |
Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-?4 antibody in adjuvant arthritis
C Barbadillo, A G-Arroyo, C Salas, J Mulero, F Snchez-Madrid, JL Andreu |
Springer Seminars in Immunopathology | 1995 |