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Citations to this article

The pathophysiologic role of alpha 4 integrins in vivo.
R R Lobb, M E Hemler
R R Lobb, M E Hemler
Published November 1, 1994
Citation Information: J Clin Invest. 1994;94(5):1722-1728. https://doi.org/10.1172/JCI117519.
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The pathophysiologic role of alpha 4 integrins in vivo.

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R R Lobb, M E Hemler

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C Kummer, MH Ginsberg
Biochemical Pharmacology 2006
Lack of α4 integrin expression in stem cells restricts competitive function and self-renewal activity
GV Priestley, LM Scott, T Ulyanova, T Papayannopoulou
Blood 2006
Blockade von Adhäsionsmolekülen mit Natalizumab in der Therapie der Multiplen Sklerose: Aktueller Studienstand
B Schreiner, BC Kieseier, HP Hartung, R Hohlfeld, H Wiendl
Der Nervenarzt 2005
Therapeutic anti-integrin (α4 and αL) monoclonal antibodies: two-edged swords?
R González-Amaro, M Mittelbrunn, F Sánchez-Madrid
Immunology 2005
PDE4 inhibitors as new anti-inflammatory drugs: Effects on cell trafficking and cell adhesion molecules expression
MJ Sanz, J Cortijo, EJ Morcillo
Pharmacology & Therapeutics 2005
Blockade von Adhäsionsmolekülen mit Natalizumab in der Therapie der Multiplen Sklerose
B Schreiner, BC Kieseier, HP Hartung, R Hohlfeld, H Wiendl
Der Nervenarzt 2005
The role of osteopontin in foreign body giant cell formation
AT Tsai, J Rice, M Scatena, L Liaw, BD Ratner, CM Giachelli
Biomaterials 2005
Involvement of α4 integrins in maintenance of cardiac sympathetic axons
KL Wingerd, WC Wayne, DY Jackson, DO Clegg
Autonomic Neuroscience 2005
NeuroImmune Biology
R Solana, G Pawelec
NeuroImmune Biology 2005
A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity
J Gläsner, H Blum, V Wehner, HU Stilz, JD Humphries, GP Curley, AP Mould, MJ Humphries, R Hallmann, M Röllinghoff, A Gessner
Journal of immunology (Baltimore, Md. : 1950) 2005
Natalizumab for the Treatment of Multiple Sclerosis and Crohn's Disease
KA Keeley, MP Rivey, DR Allington
The Annals of pharmacotherapy 2005
The Expression of α4 Integrins by Human Polymorphonuclear Neutrophils in Response to Sonicated Extracts of Enterococcus faecalis
W Shon, S Lim, K Bae, S Baek, W Lee
Journal of Endodontics 2005
Inflammatory Bowel Disease: Translation from Basic Research to Clinical Practice
, J Schölmerich, C Gasché, B Vucelic
2005
Influence of β 1 Integrin Intracytoplasmic Domains in the Regulation of VLA-4-Mediated Adhesion of Human T Cells to VCAM-1 under Flow Conditions
MA Rosenthal-Allieri, M Ticchioni, JP Breittmayer, Y Shimizu, A Bernard
Journal of immunology (Baltimore, Md. : 1950) 2005
Antisense oligonucleotide blockade of alpha 4 integrin prevents and reverses clinical symptoms in murine experimental autoimmune encephalomyelitis
KJ Myers, DR Witchell, MJ Graham, S Koo, M Butler, TP Condon
Journal of Neuroimmunology 2004
VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses
M Mittelbrunn, A Molina, MM Escribese, M Yáñez-Mó, E Escudero, A Ursa, R Tejedor, F Mampaso, F Sánchez-Madrid
Proceedings of the National Academy of Sciences 2004
Expression and function of integrin ?4?1 and vascular cell adhesion molecule-1 (VCAM-1) during sympathetic innervation of the heart
KL Wingerd, NL Goodman, ST Leu, DO Clegg
Developmental Dynamics 2004
Integrin α4β1 function is required for cell survival in developing retina
ST Leu, SA Jacques, KL Wingerd, ST Hikita, EC Tolhurst, JL Pring, D Wiswell, L Kinney, NL Goodman, DY Jackson, DO Clegg
Developmental Biology 2004
A Monoclonal Antibody to α1β1 Blocks Antigen-induced Airway Responses in Sheep
WM Abraham, A Ahmed, I Serebriakov, AN Carmillo, J Ferrant, AR de Fougerolles, EA Garber, PJ Gotwals, VE Koteliansky, F Taylor, RR Lobb
American journal of respiratory and critical care medicine 2004
Antagonism of the α4 integrin subunit attenuates the acute inflammatory response to stent implantation yet is insufficient to prevent late intimal formation
X Ma, ER O'Brien
Journal of leukocyte biology 2004
Aberrant methylation of integrin α4 gene in human gastric cancer cells
J Park, SH Song, TY Kim, MC Choi, HS Jong, TY Kim, JW Lee, NK Kim, WH Kim, YJ Bang
Oncogene 2004
Adhesion capacity and integrin expression by dendritic-like cells generated from acute myeloid leukemia blasts by calcium ionophore treatment
E Sadovnikova, EN Parovichnikova, EL Semikina, EA Kopiltsova, DA Svinareva, VM Belkin, NA Torubarova, VG Savchenko
Experimental Hematology 2004
Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention
WG Jiang, RE Mansel
2004
EWI-2 modulates lymphocyte integrin α4β1 functions
TV Kolesnikova, CS Stipp, RM Rao, WS Lane, FW Luscinskas, ME Hemler
Blood 2004
Design, Synthesis, and Analysis of a Polyethelene Glycol-Modified (PEGylated) Small Molecule Inhibitor of Integrin α4β1 with Improved Pharmaceutical Properties
RB Pepinsky, WC Lee, M Cornebise, A Gill, K Wortham, LL Chen, DR Leone, K Giza, BM Dolinski, S Perper, C Nickerson-Nutter, D Lepage, A Chakraborty, ET Whalley, RC Petter, SP Adams, RR Lobb, DM Scott
The Journal of pharmacology and experimental therapeutics 2004
Characterization of Lewis lung clonal variants in a model of syngeneic pulmonary murine metastases
BT Storey, JF Christian
Clinical & Experimental Metastasis 2004
An Assessment of the Mechanistic Differences Between Two Integrin α 4 β 1 Inhibitors, the Monoclonal Antibody TA-2 and the Small Molecule BIO5192, in Rat Experimental Autoimmune Encephalomyelitis
DR Leone, K Giza, A Gill, BM Dolinski, W Yang, S Perper, DM Scott, WC Lee, M Cornebise, K Wortham, C Nickerson-Nutter, LL Chen, D LePage, JC Spell, ET Whalley, RC Petter, SP Adams, RR Lobb, RB Pepinsky
The Journal of pharmacology and experimental therapeutics 2003
Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrin
WJ Sandborn, TA Yednock
The American Journal of Gastroenterology 2003
Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage
E Bergeron, A Basak, E Decroly, NG Seidah
Biochemical Journal 2003
Integrin α4β1 (VLA-4) expression and activity in retinal and peripheral neurons
ST Hikita, GM Cann, KL Wingerd, LH Mullick, WC Wayne, SW Webb, DO Clegg
Molecular and Cellular Neuroscience 2003
Immunosuppressive effects of a Kv1.3 inhibitor
K Shah, JT Blake, C Huang, P Fischer, GC Koo
Cellular Immunology 2003
Natalizumab for Active Crohn's Disease
S Ghosh, E Goldin, FH Gordon, HA Malchow, J Rask-Madsen, P Rutgeerts, P Vyhnálek, Z Zádorová, T Palmer, S Donoghue
New England Journal of Medicine 2003
Functional antibodies to leukocyte adhesion molecules in antithymocyte globulins1:
MC Michallet, X Preville, M Flacher, S Fournel, L Genestier, JP Revillard
Transplantation 2003
A Small Molecule Very Late Antigen–4 Antagonist Can Inhibit Ovalbumin-induced Lung Inflammation
GC Koo, K Shah, GJ Ding, J Xiao, R Wnek, G Doherty, XC Tong, RB Pepinsky, KC Lin, WK Hagmann, D Kawka, II Singer
American journal of respiratory and critical care medicine 2003
A broad-spectrum caspase inhibitor attenuates allergic airway inflammation in murine asthma model
A Iwata, K Nishio, RK Winn, EY Chi, WR Henderson, JM Harlan
Journal of immunology (Baltimore, Md. : 1950) 2003
Of Mice and Men
WM Abraham
American journal of respiratory cell and molecular biology 2003
Role of Monocytes in Atherogenesis
B Østerud, E Bjørklid
Physiological reviews 2003
Rapid Up-Regulation of α4 Integrin-mediated Leukocyte Adhesion by Transforming Growth Factor-β1
RA Bartolomé, F Sanz-Rodrı́guez, MM Robledo, A Hidalgo, J Teixidó, CH Heldin
Molecular biology of the cell 2003
Intrabody and intrakine strategies for molecular therapy
YY Wheeler, SY Chen, DC Sane
Molecular Therapy 2003
Blockade of integrin VLA-4 prevents inflammation and matrix metalloproteinase expression in a murine model of accelerated collagen-induced arthritis
Anil Raychaudhuri, Mary Chou, Marla Weetall, Arco Y Jeng
Inflammation 2003
Very late antigen-4 in CD18-independent neutrophil emigration during acute bacterial pneumonia in mice
S Tasaka, SE Richer, JP Mizgerd, CM Doerschuk
American journal of respiratory and critical care medicine 2002
alpha4 integrins and the immune response
DM Rose, J Han, MH Ginsberg
Immunological Reviews 2002
Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation
GJ Bellingan, P Xu, H Cooksley, H Cauldwell, A Shock, S Bottoms, C Haslett, SE Mutsaers, GJ Laurent
Journal of Experimental Medicine 2002
Adhesion of osteosarcoma cells to the 70-kDa core region of thrombospondin-1 is mediated by the α4β1 integrin
S Decker, F Valen, P Vischer
Biochemical and Biophysical Research Communications 2002
Inhibitors of Cell Migration that Inhibit Intracellular Paxillin/α4 Binding
Y Ambroise, B Yaspan, MH Ginsberg, DL Boger
Chemistry & Biology 2002
Clinical overview of leukocyte adhesion and migration: where are we now?
D Marshall, DO Haskard
Seminars in Immunology 2002
The discovery of small molecule carbamates as potent dual α4β1/α4β7 integrin antagonists
LL Chang, Q Truong, RA Mumford, LA Egger, U Kidambi, K Lyons, E McCauley, GV Riper, S Vincent, JA Schmidt, M MacCoss, WK Hagmann
Bioorganic & Medicinal Chemistry Letters 2002
Methods in Cell Biology
JW Smith
Methods in cell biology 2002
Adenosine Suppresses α4β7 Integrin-Mediated Adhesion of T Lymphocytes to Colon Adenocarcinoma Cells
WM MacKenzie, DW Hoskin, J Blay
Experimental Cell Research 2002
Mechanisms for sickle red blood cell retention in choroid
GA Lutty, T Otsuji, M Taomoto, C Merges, DS McLeod, SY Kim, P Vanderslice, S Suzuka, ME Fabry, RL Nagel
Current Eye Research 2002
Adhesion Molecule–dependent Mechanisms Regulate the Rate of Macrophage Clearance During the Resolution of Peritoneal Inflammation
GJ Bellingan, P Xu, H Cooksley, H Cauldwell, A Shock, S Bottoms, C Haslett, SE Mutsaers, GJ Laurent
Journal of Experimental Medicine 2002
Effects of VLA-4 antagonists in rat whole embryo culture
S Spence, C Vetter, WK Hagmann, GV Riper, H Williams, RA Mumford, TJ Lanza, LS Lin, JA Schmidt
Teratology 2002
Alpha 4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart
Kevin L Wingerd, Nichol L Goodman, Jason W Tresser, Matthew M Smail, Sergiu T Leu, Steven J Rohan, Jan L Pring, David Y Jackson, Dennis O Clegg
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas
I Lewis, B Rohde, M Mengus, M Weetall, S Maida, R Hugo, P Lake
Molecular Diversity 2002
α4 Integrins and Vascular Cell Adhesion Molecule-1 Play a Role in Sympathetic Innervation of the Heart
Wingerd KL, Goodman NL, Tresser JW, Smail MM, Leu ST, Rohan SJ, Pring JL, Jackson DY, Clegg DO
Journal of Neuroscience 2002
Encephalitogenic lymphoblast recruitment to resting central nerve system microvasculature: a natural immunosurveillance mechanism?
Ronen Alon
Journal of Clinical Investigation 2001
VLA-4-Dependent Myeloma Cell Adhesion
F Sanz-rodríguez, J Teixidó
Leukemia & Lymphoma 2001
Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells
A Hidalgo, F Sanz-Rodrı́guez, JL Rodrı́guez-Fernández, B Albella, C Blaya, N Wright, C Cabañas, F Prósper, JC Gutierrez-Ramos, J Teixidó
Experimental Hematology 2001
The use of one-bead one-compound combinatorial library method to identify peptide ligands for α4β1 integrin receptor in non-Hodgkin's lymphoma
SI Park, M Renil, B Vikstrom, N Amro, L Song, B Xu, KS Lam
Letters in Peptide Science 2001
A Homogeneous Fluorometric Assay for Measuring Cell Adhesion to Immobilized Ligand Using V-Well Microtiter Plates
M Weetall, R Hugo, S Maida, S West, S Wattanasin, R Bouhel, G Weitz-Schmidt, P Lake, C Friedman
Analytical Biochemistry 2001
Structural elements of the osteopontin SVVYGLR motif important for the interaction with α4 integrins
PM Green, SB Ludbrook, DD Miller, CM Horgan, ST Barry
FEBS Letters 2001
Beneficial effect of modified peptide inhibitor of α4 integrins on experimental allergic encephalomyelitis in Lewis rats: α4 Integrin Inhibitors Suppress EAE
LJ van der Laan, A der Goes, MH Wauben, SR Ruuls, EA Döpp, CJ de Groot, TW Kuijpers, MJ Elices, CD Dijkstra
Journal of Neuroscience Research 2001
An altered peptide ligand inhibits the activities of matrix metalloproteinase-9 and phospholipase C, and inhibits T cell interactions with VCAM-1 induced in vivo by a myasthenogenic T cell epitope
A Faber-Elmann, V Grabovsky, M Dayan, M Sela, R Alon, E Mozes
The FASEB Journal 2001
Evidence That Ligand and Metal Ion Binding to Integrin α 4 β 1 Are Regulated through a Coupled Equilibrium
LL Chen, A Whitty, D Scott, WC Lee, M Cornebise, SP Adams, RC Petter, RR Lobb, RB Pepinsky
The Journal of biological chemistry 2001
Identification of Dual α 4 β 1 Integrin Binding Sites within a 38 Amino Acid Domain in the N-terminal Thrombin Fragment of Human Osteopontin
KJ Bayless, GE Davis
The Journal of biological chemistry 2001
Central role of the ?4?1 integrin in the coordination of avian truncal neural crest cell adhesion, migration, and survival
S Testaz, JL Duband
Developmental Dynamics 2001
Inhibition of α4 Integrin Protects Against Transient Focal Cerebral Ischemia in Normotensive and Hypertensive Rats
JK Relton, KE Sloan, EM Frew, ET Whalley, SP Adams, RR Lobb
Stroke; a journal of cerebral circulation 2001
Peptides: The Wave of the Future: Proceedings of the Second International and the Seventeenth American Peptide Symposium, June 9–14, 2001, San Diego, California, U.S.A
M Lebl, RA Houghten
2001
Biotechnology Set
HJ Rehm, G Reed
2001
Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1
F Sanz-Rodrı́guez, A Hidalgo, J Teixidó
Blood 2001
In Situ Activation of Helper T Cells in the Lung
RN Moore, B Raju, CF Tung, D Cheng, N Yousefzadeh, R Condos, WN Rom, DB Tse
Infection and immunity 2001
A CD2-Green Fluorescence Protein-Transgenic Mouse Reveals Very Late Antigen-4-Dependent CD8 + Lymphocyte Rolling in Inflamed Venules
K Singbartl, J Thatte, ML Smith, K Wethmar, K Day, K Ley
Journal of immunology (Baltimore, Md. : 1950) 2001
Leukocyte integrin expression in patients undergoing cardiopulmonary bypass
G Asimakopoulos, A Kohn, DC Stefanou, DO Haskard, RC Landis, KM Taylor
The Annals of Thoracic Surgery 2000
Blockade of the integrin alphaLbeta2 but not of integrins alpha4 and/or beta7 significantly prolongs intestinal allograft survival in mice
S Sarnacki, F Auber, C Crétolle, C Camby, M Cavazzana-Calvo, W Müller, N Wagner, N Brousse, Y Révillon, A Fischer, N Cerf-Bensussan
Gut 2000
Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
V Grabovsky, S Feigelson, C Chen, DA Bleijs, A Peled, G Cinamon, F Baleux, F Arenzana-Seisdedos, T Lapidot, K Y, RR Lobb, R Alon
Journal of Experimental Medicine 2000
Subsecond Induction of  4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions
V Grabovsky, S Feigelson, C Chen, DA Bleijs, A Peled, G Cinamon, F Baleux, F Arenzana-Seisdedos, T Lapidot, Y Kooyk, RR Lobb, R Alon
Journal of Experimental Medicine 2000
Novel Roles for Integrins in the Nervous System
DO Clegg
Molecular Cell Biology Research Communications 2000
Production of recombinant soluble human integrin α4β1
K Clark, P Newham, L Burrows, JA Askari, MJ Humphries
FEBS Letters 2000
Effect of antibody against integrin alpha4 on bleomycin-induced pulmonary fibrosis in mice
Q Wang, Y Wang, DM Hyde, PJ Gotwals, RR Lobb, ST Ryan, SN Giri
Biochemical Pharmacology 2000
Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice
A Kanehiro, K Takeda, A Joetham, A Tomkinson, T Ikemura, CG Irvin, EW Gelfand
American journal of respiratory and critical care medicine 2000
The Adhesion Molecule FactsBook
CM Isacke, MA Horton
The Adhesion Molecule FactsBook 2000
A Small-Molecule, Tight-binding Inhibitor of the Integrin α 4 β 1 Blocks Antigen-induced Airway Responses and Inflammation in Experimental Asthma in Sheep
WM Abraham, A Gill, A Ahmed, MW Sielczak, IT Lauredo, Y Botinnikova, KC Lin, B Pepinsky, DR Leone, RR Lobb, SP Adams
American journal of respiratory and critical care medicine 2000
Analysis of the α4β1 Integrin–Osteopontin Interaction
ST Barry, SB Ludbrook, E Murrison, CM Horgan
Experimental Cell Research 2000
The role of α4 and LFA-1 integrins in selectin-independent monocyte and neutrophil migration to joints of rats with adjuvant arthritis
U Birner, TB Issekutz, U Walter, AC Issekutz
International Immunology 2000
The α 4 Integrin Subunit Tyr 187 Has a Key Role in α 4 β 7 -Dependent Cell Adhesion
N Ruiz-Velasco, M Guerrero-Esteo, MJ Briskin, J Teixidó
The Journal of biological chemistry 2000
Novel Therapeutic Proteins: Selected Case Studies
K Dembowsky, P Stadler
2000
Cell adhesion receptors in lymphoma dissemination
P Drillenburg, ST Pals
Blood 2000
The parting of the endothelium: miracle, or simply a junctional affair?
C Johnson-Leger, M Aurrand-Lions, BA Imhof
Journal of cell science 2000
Potent Costimulation of Effector T Lymphocytes by Human Collagen Type I
WH Rao, JM Hales, RD Camp
Journal of immunology (Baltimore, Md. : 1950) 2000
Up-Regulation of VCAM-1 and Differential Expansion of β Integrin-Expressing T Lymphocytes Are Associated with Immunity to Pulmonary Mycobacterium tuberculosis Infection
CG Feng, WJ Britton, U Palendira, NL Groat, H Briscoe, AG Bean
Journal of immunology (Baltimore, Md. : 1950) 2000
Maturation-Dependent Expression and Function of the CD49d Integrin on Monocyte-Derived Human Dendritic Cells
A Puig-Kröger, F Sanz-Rodríguez, N Longo, P Sánchez-Mateos, L Botella, J Teixidó, C Bernabéu, AL Corbí
Journal of immunology (Baltimore, Md. : 1950) 2000
In Vivo Roles of Integrins During Leukocyte Development and Traffic: Insights from the Analysis of Mice Chimeric for α 5 , α v , and α 4 Integrins
AG Arroyo, D Taverna, CA Whittaker, UG Strauch, BL Bader, H Rayburn, D Crowley, CM Parker, RO Hynes
Journal of immunology (Baltimore, Md. : 1950) 2000
A novel RGD-independent fibronectin assembly pathway initiated by alpha4beta1 integrin binding to the alternatively spliced V region
JL Sechler, AM Cumiskey, DM Gazzola, JE Schwarzbauer
Journal of cell science 2000
Expression of Mucosal Homing Receptor α4β7 Is Associated with Enhanced Migration to the Chlamydia -Infected Murine Genital Mucosa In Vivo
JD Clements, RA Hawkins, RG Rank, KA Kelly
Infection and immunity 2000
VCAM-1 has a tissue-specific role in mediating interleukin-4–induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration
KY Larbi, AR Allen, FW Tam, DO Haskard, RR Lobb, PM Silva, S Nourshargh
Blood 2000
Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating β1 integrin
PT Shih, MJ Elices, ZT Fang, TP Ugarova, D Strahl, MC Territo, JS Frank, NL Kovach, C Cabanas, JA Berliner, DK Vora
Journal of Clinical Investigation 1999
Erythroid cell adhesion molecules Lutheran and LW in health and disease
SF Parsons, FA Spring, JA Chasis, DJ Anstee
Best Practice & Research Clinical Haematology 1999
Peptide and peptidomimetic inhibitors of VLA-4
CN Zimmerman
Expert Opinion on Therapeutic Patents 1999
Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of alpha4 integrins and vascular cell adhesion molecule-1
K Nagai, S Larkin, A Hartnell, K Larbi, MR Aghakhani, C Windley, D Davies, RR Lobb, TJ Williams, S Nourshargh
Immunology 1999
VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin
D Davies, K Larbi, A Allen, M Sanz, VB Weg, DO Haskard, RR Lobb, S Nourshargh
Immunology 1999
Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus
JR Silva, C Ruffié, J Lefort, MA Nahori, BB Vargaftig, M Pretolani
Mediators of Inflammation 1999
Independent repressor domains in ZEB regulate muscle and T-cell differentiation
AA Postigo, DC Dean
Molecular and cellular biology 1999
Th1/Th2 subsets: distinct differences in homing and chemokine receptor expression?
U Syrbe, J Siveke, A Hamann
Springer Seminars in Immunopathology 1999
α4 Integrins Regulate the Proliferation/Differentiation Balance of Multilineage Hematopoietic Progenitors In Vivo
AG Arroyo, JT Yang, H Rayburn, RO Hynes
Immunity 1999
Small molecule antagonists of α4 integrins: novel drugs for asthma
RR Lobb, SP Adams
Expert Opinion on Investigational Drugs 1999
The α4-integrin: an alternative pathway for neutrophil recruitment?
B Johnston, P Kubes
Immunology Today 1999
alpha4 integrin-dependent eotaxin induction of bronchial hyperresponsiveness and eosinophil migration in interleukin-5 transgenic mice
T Hisada, PG Hellewell, MM Teixeira, MG Malm, M Salmon, TJ Huang, KF Chung
American journal of respiratory cell and molecular biology 1999
Homing of human cells in the fetal sheep model: modulation by antibodies activating or inhibiting very late activation antigen-4-dependent function
E D Zanjani, A W Flake, G Almeida-Porada, N Tran, T Papayannopoulou
Journal of Clinical Investigation 1999
Multiple Activation States of Integrin α 4 β 1 Detected through Their Different Affinities for a Small Molecule Ligand
LL Chen, A Whitty, RR Lobb, SP Adams, RB Pepinsky
The Journal of biological chemistry 1999
EC3, a Novel Heterodimeric Disintegrin from Echis carinatus Venom, Inhibits α4 and α5 Integrins in an RGD-independent Manner
C Marcinkiewicz, JJ Calvete, MM Marcinkiewicz, M Raida, S Vijay-Kumar, Z Huang, RR Lobb, S Niewiarowski
The Journal of biological chemistry 1999
Total Synthesis of HUN-7293
DL Boger, H Keim, B Oberhauser, EP Schreiner, CA Foster
Journal of the American Chemical Society 1999
Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents
KC Lin, AC Castro
Current Opinion in Chemical Biology 1998
Expression of alpha5 (CD49e) and alpha6 (CD49f) Integrin Subunits on T Cells in the Circulation and the Lamina Propria of Normal and Inflammatory Bowel Disease Colonic Mucosa
Pilling, Galvin, Robins, Sewell, Mahida
Scandinavian Journal of Immunology 1998
T cell interaction with ICAM-1-deficient endotheliumin vitro: essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells
Y Reiss, G Hoch, U Deutsch, B Engelhardt
European Journal of Immunology 1998
Role of two conserved glycine residues in the β-propeller domain of the integrin α4 subunit in VLA-4 conformation and function
M Guerrero-Esteo, N Ruiz-Velasco, M Muñoz, J Teixidó
FEBS Letters 1998
Involvement of Intercellular Adhesion Molecule-1 in the Antigen-induced Infiltration of Eosinophils and Lymphocytes into the Airways in a Murine Model of Pulmonary Inflammation
JE Chin, GE Winterrowd, CA Hatfield, JR Brashler, RL Griffin, SL Vonderfecht, KP Kolbasa, SF Fidler, KL Shull, RF Krzesicki, KA Ready, CJ Dunn, LM Sly, ND Staite, IM Richards
American journal of respiratory cell and molecular biology 1998
Encyclopedia of Immunology
RL Riley
Encyclopedia of Immunology 1998
Biotechnology: A: Recombinant Proteins, Monoclonal Antibodies, and Therapeutic Genes
HJ Rehm, G Reed
1998
Neuroinflammation
PL Wood
Neuroinflammation 1998
Leukocyte Integrins in the Immune System and Malignant Disease
B Holzmann, H Wagner
1998
Osteopontin is a ligand for the alpha4beta1 integrin
KJ Bayless, GA Meininger, JM Scholtz, GE Davis
Journal of cell science 1998
Anti–VLA4/VCAM-1—Induced Mobilization Requires Cooperative Signaling Through the kit/mkit Ligand Pathway
T Papayannopoulou, GV Priestley, B Nakamoto
Blood 1998
Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways
AD Fryer, RW Costello, BL Yost, RR Lobb, TF Tedder, DA Steeber, BS Bochner
Journal of Clinical Investigation 1997
Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma
WR Henderson, EY Chi, RK Albert, SJ Chu, WJ Lamm, Y Rochon, M Jonas, PE Christie, JM Harlan
Journal of Clinical Investigation 1997
Adhesion molecules. A rheumatologic perspective
CF Mojcik, EM Shevach
Arthritis & Rheumatism 1997
c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB
AA Postigo, AM Sheppard, ML Mucenski, DC Dean
The EMBO Journal 1997
ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation
AA Postigo, DC Dean
The EMBO Journal 1997
Beta 2 (CD18) and beta 1 (CD29) integrin mechanisms in migration of human polymorphonuclear leucocytes and monocytes through lung fibroblast barriers: shared and distinct mechanisms
XZ Shang, AC Issekutz
Immunology 1997
The beta 1 integrin, very late activation antigen-4 on human neutrophils can contribute to neutrophil migration through connective tissue fibroblast barriers
JX Gao, AC Issekutz
Immunology 1997
A novel region of the alpha4 integrin subunit with a modulatory role in VLA-4-mediated cell adhesion to fibronectin
M Muñoz, J Serrador, M Nieto, A Luque, F Sánchez-Madrid, J Teixidó
Biochemical Journal 1997
Expression of fibronectin splicing variants in organ transplantation: a differential pattern between rat cardiac allografts and isografts
AJ Coito, LF Brown, JH Peters, JW Kupiec-Weglinski, L de Water
The American Journal of Pathology 1997
Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1)
Q Yuan, KF Austen, DS Friend, M Heidtman, JA Boyce
Journal of Experimental Medicine 1997
Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatis
KA Kelly, RG Rank
Infection and immunity 1997
Transcriptional activation of the vascular cell adhesion molecule-1 gene in T lymphocytes expressing human T-cell leukemia virus type 1 Tax protein
H Valentin, I Lemasson, S Hamaia, H Cassé, S König, C Devaux, L Gazzolo
Journal of virology 1997
Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1
A Irie, T Kamata, Y Takada
Proceedings of the National Academy of Sciences 1997
Alpha 4 beta 7 integrin expression is associated with the leukemic evolution of human and murine T-cell lymphoblastic lymphomas
R Dolcetti, R Giardini, C Doglioni, R Cariati, F Pomponi, C D'Orazi, S Rao, AI Lazarovits, EC Butcher, M Boiocchi
The American Journal of Pathology 1997
Activation status and function of the VLA-4 (α4β1) integrin expressed on human melanoma cell lines
A Saini, Z Seller, D Davies, JF Marshall, IR Hart
International Journal of Cancer 1997
Therapy with antibody against leukocyte integrin VLA-4 (CD49d) is effective and safe in virus-facilitated experimental allergic encephalomyelitis
M Soilu-Hänninen, M Röyttä, A Salmi, R Salonen
Journal of Neuroimmunology 1997
Human Peripheral Blood Eosinophils Express a Functional c-kit Receptor for Stem Cell Factor that Stimulates Very Late Antigen 4 (VLA-4)-mediated Cell Adhesion to Fibronectin and Vascular Cell Adhesion Molecule 1 (VCAM-1)
Q Yuan, KF Austen, DS Friend, M Heidtman, JA Boyce
Journal of Experimental Medicine 1997
Advances in Molecular and Cell Biology
KJ Clemetson
Advances in Molecular and Cell Biology 1997
The Leucocyte Antigen FactsBook
AN Barclay, MH Brown, SK Law, AJ McKnight, MG Tomlinson, PA van der Merwe
The Leucocyte Antigen FactsBook 1997
Multiple loop structures critical for ligand binding of the integrin  4 subunit in the upper face of the  -propeller mode 1
A Irie, T Kamata, Y Takada
Proceedings of the National Academy of Sciences 1997
The role of platelets in the early and late vascular responses initiated by mechanical vascular injury
LA Harker
Fibrinolysis and Proteolysis 1997
Adhesion molecules as determinants of disease: From molecular biology to surgical research
MD Menger, B Vollmar
British Journal of Surgery 1996
VCAM-1/α4-integrin adhesion pathway: Therapeutic target for allergic inflammatory disorders
CA Foster
Journal of Allergy and Clinical Immunology 1996
Pathophysiologic Role of ?4 Integrins in the Lung
RR Lobb, WM Abraham, LC Burkly, A Gill, W Ma, JA Knight, DR Leone, G Antognetti, RB Pepinsky
Annals of the New York Academy of Sciences 1996
Adhesion Molecules-Their Role in Health and Disease
A Etzioni
Pediatric Research 1996
The α4β1 Fibronectin Ligands CS-19 HEP II, and RGD Induce Different Intracellular Events in B Lymphoid Cells. Comparison with the Effects of the Endothelial Ligand V CAM-1
C Domínguez-Jimenez, P Sánchez-Aparicio, JP Albarb, A García-Pardoa
Cell Communication and Adhesion 1996
Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis
C Weber, R Alon, B Moser, TA Springer
The Journal of Cell Biology 1996
Intracellular single-chain antibody inhibits integrin VLA-4 maturation and function
Q Yuan, KL Strauch, RR Lobb, ME Hemler
Biochemical Journal 1996
Predominant role of alpha 4-integrins for distinct steps of lymphoma metastasis
U Gosslar, P Jonas, A Luz, A Lifka, D Naor, A Hamann, B Holzmann
Proceedings of the National Academy of Sciences 1996
The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo
B Johnston, TB Issekutz, P Kubes
Journal of Experimental Medicine 1996
Expression of VCAM-1 and VLA-4 dependent T-lymphocyte adhesion to dermal fibroblasts stimulated with proinflammatory cytokines
JX Gao, AC Issekutz
Immunology 1996
Integrin alpha 4 cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to alpha 4/180 formation
C Pujades, J Teixidó, G Bazzoni, ME Hemler
Biochemical Journal 1996
Essentials of Mucosal Immunology
DK Podolsky
Essentials of Mucosal Immunology 1996
Therapeutic Effects of Antibodies Against Adhesion Molecules in Murine Collagen Type II-Induced Arthritis
A Zeidler, R Bräuer, K Thoss, J Bahnsen, V Heinrichs, D Jablonski-Westrich, M Wroblewski, S Rebstock, A Hamann
Autoimmunity 1995
Adhesion molecules in health and disease
RJ Faull
Australian and New Zealand Journal of Medicine 1995
Vascular Cell Adhesion Molecule (VCAM)-Ig Fusion Protein Defines Distinct Affinity States of the Very Late Antigen-4 (VLA-4) Receptor
A Jakubowski, MD Rosa, S Bixler, R Lobb, LC Burkly
Cell Communication and Adhesion 1995
Biologic therapy for inflammatory bowel disease
BE Sands
Inflammatory Bowel Diseases
Fatalities in natalizumab treatment - a 'no go for leukocyte recirculation approaches?
YY Li, HD Perez, TM Zollner
Expert Opinion on Therapeutic Targets 2006
A Direct Binding Assay for the Vascular Cell Adhesion Molecule-1 (VCAM1) Interaction with α4 Integrins
RR Lobb, G Antognetti, RB Pepinsky, LC Burkly, DR Leone, A Whitty
Cell Communication and Adhesion 1995
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1
R Alon, PD Kassner, MW Carr, EB Finger, ME Hemler, TA Springer
The Journal of Cell Biology 1995
Extracellular matrix proteins, regulators of T-cell functions in healthy and diseased individuals
A Gorski, JW Kupiec-Weglinski
Clinical and diagnostic laboratory immunology 1995
Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits
A Irie, T Kamata, W Puzon-McLaughlin, Y Takada
The EMBO Journal 1995
Determinant-Regulated Onset of Experimental Autoimmune Encephalomyelitis: Distinct Epitopes of Myelin Proteolipid Protein Mediate Either Acute or Delayed Disease in SJL/J Mice
VK Tuohy, DM Thomas, T Haqqi, M Yu, JM Johnson
Autoimmunity 1995
Molecular and cellular interactions mediating granulocyteaccumulation in vivo
S Nourshargh, TJ Williams
Seminars in Cell Biology 1995
Biologic Therapy for Inflammatory Bowel Disease:
BE Sands
Inflammatory Bowel Diseases
Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet
PT Shih, ML Brennan, DK Vora, MC Territo, D Strahl, MJ Elices, AJ Lusis, JA Berliner
Circulation research 1999
Fibronectin: structure, assembly, and cardiovascular implications
MK Magnusson, DF Mosher
Arteriosclerosis, thrombosis, and vascular biology 1998
Blockade of Late-phase Airway Responses and Airway Hyperresponsiveness in Allergic Sheep with a Small-molecule Peptide Inhibitor of VLA-4
WM Abraham, A Ahmed, MW Sielczak, M Narita, T Arrhenius, MJ Elices
American journal of respiratory and critical care medicine 1997
VLA-4-Mediated Interactions Between Normal Human Hematopoietic Progenitors and Stromal Cells
RA Oostendorp, P Dörmer
Leukemia & Lymphoma 1997
Role of Cell Adhesion Molecules in Inflammatory Bowel Diseases
B Vainer
Scandinavian Journal of Gastroenterology 1997
Cross Talk between Adhesion Molecules: Control of N-cadherin Activity by Intracellular Signals Elicited by β1 and β3 Integrins in Migrating Neural Crest Cells
F Monier-Gavelle, JL Duband
The Journal of Cell Biology 1997
Generation of Monoclonal Antibodies to Integrin-associated Proteins: EVIDENCE THAT α 3 β 1 COMPLEXES WITH EMMPRIN/BASIGIN/OX47/M6
F Berditchevski, S Chang, J Bodorova, ME Hemler
The Journal of biological chemistry 1997
Defining Extracellular Integrin α-Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding
C Pujades, R Alon, RL Yauch, A Masumoto, LC Burkly, C Chen, TA Springer, RR Lobb, ME Hemler
Molecular biology of the cell 1997
Forschung in der Chirurgie
HG Berger, A Schwarz, UB Brückner, W Hartel
1997
Tumor Necrosis Factor α-Induced Eosinophil Accumulation in Rat Skin Is Dependent on α4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways
MJ Sanz, A Hartnell, P Chisholm, C Williams, D Davies, VB Weg, M Feldmann, MA Bolanowski, RR Lobb, S Nourshargh
Blood 1997
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1): Its binding motif for α4β7 and role in experimental colitis
S Fong, S Jones, ME Renz, HH Chiu, AM Ryan, LG Presta, D Jackson
Immunologic Research 1997
Molecular Cloning and Expression of the Gene for Elastin-binding Protein ( ebpS ) in Staphylococcus aureus
PW Park, J Rosenbloom, WR Abrams, J Rosenbloom, RP Mecham
The Journal of biological chemistry 1996
Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo
D Raeburn, MA Giembycz
1996
Attempts to Understand Metastasis Formation II
U Günthert, W Birchmeier
1996
A Region of the Integrin VLAα4 Subunit Involved in Homotypic Cell Aggregation and in Fibronectin but Not Vascular Cell Adhesion Molecule-1 Binding
M Muñoz, J Serrador, F Sánchez-Madrid, J Teixidó
The Journal of biological chemistry 1996
Differential Regulation of Integrin-dependent Binding to Domains 1 and 4 of Vascular Cell Adhesion Molecule-1
G Kilger, LA Needham, PJ Nielsen, J Clements, D Vestweber, B Holzmann
The Journal of biological chemistry 1995
Molecular mapping of functional antibody binding sites of α4
SG Schiffer, ME Hemler, RR Lobb, R Tizard, L Osborn
The Journal of biological chemistry 1995
Molecular analysis of the physiological and pathophysiological role of ?4-integrins
G Kilger, B Holzmann
Journal of Molecular Medicine 1995
Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-?4 antibody in adjuvant arthritis
C Barbadillo, A G-Arroyo, C Salas, J Mulero, F Snchez-Madrid, JL Andreu
Springer Seminars in Immunopathology 1995

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