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Citations to this article

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.
F H Durie, … , L D Fast, R J Noelle
F H Durie, … , L D Fast, R J Noelle
Published September 1, 1994
Citation Information: J Clin Invest. 1994;94(3):1333-1338. https://doi.org/10.1172/JCI117453.
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Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

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Abstract

Chronic and acute graft-versus-host disease (cGVHD and aGVHD) result from donor cells responding to host disparate MHC alleles. In cGVHD (H-2d-->H-2bd), heightened polyclonal immunoglobulin production is due to the interaction of donor allospecific helper T cells (Th) and the host B cells. In vivo administration of antibody to the ligand for CD40, gp39, blocked cGVHD-induced serum anti-DNA autoantibodies, IgE production, spontaneous immunoglobulin production in vitro, and associated splenomegaly. Antibody production remained inhibited for extended periods of time after termination of anti-gp39 administration. Antiallogeneic CTL responses induced in a GVHD were also prevented by the in vivo administration of anti-gp39 as was the associated splenomegaly. These data suggest that CD40-gp39 interactions are critical in GVHD and that CD40-gp39 may be a valuable ligand-receptor pair for targeting immunotherapeutic agents to control GVHD.

Authors

F H Durie, A Aruffo, J Ledbetter, K M Crassi, W R Green, L D Fast, R J Noelle

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Leukemia & Lymphoma 1996
Interleukin-12 Production by Dendritic Cells
BL Kelsall, E Stüber, M Neurath, W Strober
Annals of the New York Academy of Sciences 1996
CD40/CD40 ligand interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages
MK Kennedy, KS Picha, WC Fanslow, KH Grabstein, MR Alderson, KN Clifford, WA Chin, KM Mohler
European Journal of Immunology 1996
The relative contribution of the CD28 and gp39 costimulatory pathways in the clonal expansion and pathogenic acquisition of self-reactive T cells
ND Griggs, SS Agersborg, RJ Noelle, JA Ledbetter, PS Linsley, KS Tung
Journal of Experimental Medicine 1996
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
WW Hancock, MH Sayegh, XG Zheng, R Peach, PS Linsley, LA Turka
Proceedings of the National Academy of Sciences 1996
Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
E Stuber, W Strober, M Neurath
Journal of Experimental Medicine 1996
BYSTANDER INJURY OF HOST LYMPHOID TISSUE DURING MURINE GRAFT-VERSUS-HOST DISEASE IS MEDIATED BY NITRIC OXIDE1:
RA Hoffman, JM Langrehr, LA Berry, DA White, NC Schattenfroh, SA MaCarthy, RL Simmons
Transplantation 1996
Blood Cell Biochemistry
AD Whetton, J Gordon
1996
CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression
K Karmann, CC Hughes, J Schechner, WC Fanslow, JS Pober
Proceedings of the National Academy of Sciences 1995
Cleavable CD40Ig fusion proteins and the binding to sgp39
D Hollenbaugh, J Douthwright, V McDonald, A Aruffo
Journal of Immunological Methods 1995
In the absence of a CD40 signal, B cells are tolerogenic
J E Buhlmann, T M Foy, A Aruffo, K M Crassi, J A Ledbetter, W R Green, J C Xu, L D Shultz, D Roopesian, R A Flavell
Immunity 1995
Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment
BR Blazar, R Korngold, DA Vallera
Journal of immunology (Baltimore, Md. : 1950) 1994

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Referenced in 27 patents
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