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Citations to this article

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.
F H Durie, … , L D Fast, R J Noelle
F H Durie, … , L D Fast, R J Noelle
Published September 1, 1994
Citation Information: J Clin Invest. 1994;94(3):1333-1338. https://doi.org/10.1172/JCI117453.
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Research Article Article has an altmetric score of 3

Antibody to the ligand of CD40, gp39, blocks the occurrence of the acute and chronic forms of graft-vs-host disease.

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Abstract

Chronic and acute graft-versus-host disease (cGVHD and aGVHD) result from donor cells responding to host disparate MHC alleles. In cGVHD (H-2d-->H-2bd), heightened polyclonal immunoglobulin production is due to the interaction of donor allospecific helper T cells (Th) and the host B cells. In vivo administration of antibody to the ligand for CD40, gp39, blocked cGVHD-induced serum anti-DNA autoantibodies, IgE production, spontaneous immunoglobulin production in vitro, and associated splenomegaly. Antibody production remained inhibited for extended periods of time after termination of anti-gp39 administration. Antiallogeneic CTL responses induced in a GVHD were also prevented by the in vivo administration of anti-gp39 as was the associated splenomegaly. These data suggest that CD40-gp39 interactions are critical in GVHD and that CD40-gp39 may be a valuable ligand-receptor pair for targeting immunotherapeutic agents to control GVHD.

Authors

F H Durie, A Aruffo, J Ledbetter, K M Crassi, W R Green, L D Fast, R J Noelle

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Total citations by year

Year: 2022 2019 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 Total
Citations: 3 1 2 1 5 3 1 2 3 2 17 2 4 3 1 3 12 9 13 5 9 11 14 17 3 1 147
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2010 (2)

Title and authors Publication Year
Intervention with costimulatory pathways as a therapeutic approach for graft-versus-host disease
B Kwon
Experimental & molecular medicine 2010
Methods in Microbiology
V Tchikov, J Fritsch, D Kabelitz, S Schütze
Methods in Microbiology 2010

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Referenced in 27 patents
20 readers on Mendeley
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