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Citations to this article

A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2.
T G Diacovo, … , D F Bainton, T A Springer
T G Diacovo, … , D F Bainton, T A Springer
Published September 1, 1994
Citation Information: J Clin Invest. 1994;94(3):1243-1251. https://doi.org/10.1172/JCI117442.
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Research Article Article has an altmetric score of 3

A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2.

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Abstract

Activated platelets express P-selectin and release leukocyte chemoattractants; however, they have not been known to express integrin ligands important in the stabilization of leukocyte interactions with the vasculature. We now demonstrate the presence of intercellular adhesion molecular-2 (ICAM-2) (CD102), and lack of expression of other beta 2-integrin ligands, ICAM-1 (CD54) and ICAM-3 (CD50), on the surface of resting and stimulated platelets. ICAM-2 isolated from platelets migrates as a band of 59,000 M(r) in reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Staining of bone marrow aspirates with anti-ICAM-2 mAb demonstrates strong reactivity to megakaryocytes. Using frozen thin sections and immunogold labeling, the antigen was shown to be present on the plasma membrane and surface-connected canalicular system of resting platelets. The average number of ICAM-2 molecules per platelet is 3,000 +/- 230 and does not change after activation. In adhesion assays, resting and stimulated platelets were capable of binding through ICAM-2 to purified leukocyte function-associated antigen-1. Activation of T lymphocytes with PMA stimulated binding to platelets that was Mg2+ dependent and could be specifically inhibited by mAbs to either ICAM-2 or leukocyte function-associated antigen-1. ICAM-2 is the only known beta 2-integrin ligand present on platelets, suggesting that it may play an important role in leukocyte-platelet interactions in inflammation and thrombosis.

Authors

T G Diacovo, A R deFougerolles, D F Bainton, T A Springer

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Citations to this article in year 2012 (7)

Title and authors Publication Year
Glutathione-dependent regulation of platelet aggregation with neutrophils and tumor cells
IV Gorudko, EV Shamova, LM Shishlo, AV Mukhortova, VI Prokhorova, OM Panasenko, SA Gusev, SN Cherenkevich
Biophysics 2012
Role of intercellular adhesion molecule-2 in osteoclastogenesis
X Li, M Akiyama, K Nakahama, T Koshiishi, S Takeda, I Morita
Genes to Cells 2012
On the roles of polyvalent binding in immune recognition: Perspectives in the nanoscience of immunology and the immune response to nanomedicines
T Vorup-Jensen
Advanced Drug Delivery Reviews 2012
Eugenosedin-A prevents high-fat diet increased adhesion molecules through inhibition of MAPK- and p65-mediated NF-κB pathway in rat model: Hyperlipidaemia-induced cell adhesion
HL Lin, KP Shen, WT Chang, JC Lin, LM An, IJ Chen, BN Wu
Journal of Pharmacy and Pharmacology 2012
The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways
JM Burkhart, M Vaudel, S Gambaryan, S Radau, U Walter, L Martens, J Geiger, A Sickmann, RP Zahedi
Blood 2012
Platelets: key players in vascular inflammation
D Projahn, RR Koenen
Journal of leukocyte biology 2012
The Initial Hours of Metastasis: The Importance of Cooperative Host–Tumor Cell Interactions during Hematogenous Dissemination
M Labelle, RO Hynes
Cancer Discovery 2012

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