We tested the hypothesis that pulmonary surfactant-associated lectins--surfactant proteins A and D (SP-A, and -D)--contribute to initial protective mechanisms against influenza A viruses (IAVs). SP-D potently inhibited hemagglutination activity of several strains of IAV as well as causing viral aggregation. SP-D enhanced neutrophil binding of IAV and neutrophil respiratory burst responses to the virus. Neutrophil dysfunction resulting from IAV exposure was diminished when the virus was pre-incubated with SP-D. Each of these effects was mediated by the calcium-dependent carbohydrate-binding property of SP-D. Native SP-D preparations of both human and rat origin, as well as recombinant rat SP-D, had similar activity. SP-A also inhibited IAV hemagglutination activity. We have previously reported that related mammalian serum lectins (mannose-binding lectin [MBL] and conglutinin) have similar effects. SP-D was at least 10-fold more potent at causing hemagglutination inhibition than were SP-A or MBL. SP-D was shown to contribute to potent anti-IAV activity of human bronchoalveolar lavage fluid. These results suggest that SP-D--alone, and in conjunction with SP-A and phagocytic cells--constitutes an important component of the natural immune response to IAV infection within the respiratory tract.
K L Hartshorn, E C Crouch, M R White, P Eggleton, A I Tauber, D Chang, K Sastry
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Lectin in Host Defense Against Microbial Infections
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Lectin in Host Defense Against Microbial Infections
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The Role and Molecular Mechanism of Action of Surfactant Protein D in Innate Host Defense Against Influenza A Virus
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Molecular & cellular proteomics : MCP | 2016 |
CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo
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Clinical and vaccine immunology : CVI | 2015 |
Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses
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CpG Oligodeoxynucleotides Facilitate Delivery of Whole Inactivated H9N2 Influenza Virus via Transepithelial Dendrites of Dendritic Cells in Nasal Mucosa
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The Roles of Direct Recognition by Animal Lectins in Antiviral Immunity and Viral Pathogenesis
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Molecules (Basel, Switzerland) | 2015 |
The amazing innate immune response to influenza A virus infection
S Tripathi, MR White, KL Hartshorn |
Innate immunity | 2015 |
Arginine-rich histones have strong antiviral activity for influenza A viruses
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Dipeptidyl Peptidase I Controls Survival from Klebsiella pneumoniae Lung Infection by Processing Surfactant Protein D
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A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus
X Yang, L Steukers, K Forier, R Xiong, K Braeckmans, KV Reeth, H Nauwynck, NM Bouvier |
PloS one | 2014 |
LL-37 modulates human neutrophil responses to influenza A virus
S Tripathi, A Verma, EJ Kim, MR White, KL Hartshorn |
Journal of leukocyte biology | 2014 |
Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses
NM Nikolaidis, MR White, K Allen, S Tripathi, L Qi, B McDonald, J Taubenberger, BA Seaton, FX McCormack, EC Crouch, KL Hartshorn |
American journal of physiology. Lung cellular and molecular physiology | 2014 |
Bitter-sweet symphony: glycan–lectin interactions in virus biology
WV Breedam, S Pöhlmann, HW Favoreel, RJ de Groot, HJ Nauwynck |
FEMS Microbiology Reviews | 2014 |
The Complement System
M Gadjeva |
2013 | |
The Complement System
M Gadjeva |
2013 | |
The Complement System
M Gadjeva |
2013 | |
The Complement System
M Gadjeva |
2013 | |
The Complement System
M Gadjeva |
2013 | |
The Complement System
M Gadjeva |
2013 | |
The Complement System
M Gadjeva |
2013 | |
The Complement System
M Gadjeva |
2013 | |
Surfactant Protein D Modulates HIV Infection of Both T-Cells and Dendritic Cells
J Madsen, GD Gaiha, N Palaniyar, T Dong, DA Mitchell, HW Clark, WR Abrams |
PloS one | 2013 |
Why Does Pandemic Influenza Virus Kill?
KL Hartshorn |
The American Journal of Pathology | 2013 |
Age- and Sex-Associated Differences in the Glycopatterns of Human Salivary Glycoproteins and Their Roles against Influenza A Virus
Y Qin, Y Zhong, M Zhu, L Dang, H Yu, Z Chen, W Chen, X Wang, H Zhang, Z Li |
Journal of Proteome Research | 2013 |
Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation
BC Goh, MJ Rynkiewicz, TR Cafarella, MR White, KL Hartshorn, K Allen, EC Crouch, O Calin, PH Seeberger, K Schulten, BA Seaton |
Biochemistry | 2013 |
Protective Effect of Surfactant Protein D in Pulmonary Vaccinia Virus Infection: Implication of A27 Viral Protein
P Julien, N Thielens, E Crouch, D Spehner, JM Crance, AL Favier |
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Neutrophils are needed for an effective immune response against pulmonary rat coronavirus infection, but also contribute to pathology
AK Haick, JP Rzepka, E Brandon, OB Balemba, TA Miura |
Journal of General Virology | 2013 |
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MC Elie, D Carden |
Colloquium Series on Integrated Systems Physiology From Molecule to Function | 2013 |
Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses
ER Job, B Bottazzi, B Gilbertson, KM Edenborough, LE Brown, A Mantovani, AG Brooks, PC Reading, MC Chan |
PloS one | 2013 |
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ER Job, B Bottazzi, KR Short, YM Deng, A Mantovani, AG Brooks, PC Reading |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
Pulmonary Surfactant Protein D in First-Line Innate Defence against Influenza A Virus Infections
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Journal of Innate Immunity | 2013 |
An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity
A Nayak, E Dodagatta-Marri, AG Tsolaki, U Kishore |
Frontiers in immunology | 2012 |
The human side of influenza
CM Oshansky, PG Thomas |
Journal of leukocyte biology | 2012 |
Soluble Host Defense Lectins in Innate Immunity to Influenza Virus
WC Ng, MD Tate, AG Brooks, PC Reading |
Journal of Biomedicine and Biotechnology | 2012 |
Development of a murine nose-only inhalation model of influenza: comparison of disease caused by instilled and inhaled A/PR/8/34
LE Bowen, K Rivers, JE Trombley, JK Bohannon, SX Li, JA Boydston, MC Eichelberger |
Frontiers in Cellular and Infection Microbiology | 2012 |
Unifying thoracic biomarkers: surfactant protein-D and beyond
JE Jaw, DD Sin |
Expert Review of Respiratory Medicine | 2012 |
The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins
S Tripathi, T Tecle, A Verma, E Crouch, M White, KL Hartshorn |
Journal of General Virology | 2012 |
Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses
A Verma, M White, V Vathipadiekal, S Tripathi, J Mbianda, M Ieong, L Qi, JK Taubenberger, K Takahashi, JC Jensenius, S Thiel, KL Hartshorn |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D
M Eijk, MJ Rynkiewicz, MR White, KL Hartshorn, X Zou, K Schulten, D Luo, EC Crouch, TR Cafarella, JF Head, HP Haagsman, BA Seaton |
The Journal of biological chemistry | 2012 |
Hapivirins and diprovirins: novel θ-defensin analogs with potent activity against influenza A virus
M Doss, P Ruchala, T Tecle, D Gantz, A Verma, A Hartshorn, EC Crouch, H Luong, ED Micewicz, RI Lehrer, KL Hartshorn |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
Antimicrobial Peptides and Innate Immunity
PS Hiemstra, SA Zaat |
2012 | |
Pulmonary Collectins in Diagnosis and Prevention of Lung Diseases
Gupta A |
2012 | |
Implications of the innate immune response to adenovirus and adenoviral vectors
SM Gregory, SA Nazir, JP Metcalf |
Future Virology | 2011 |
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AD Postle, NG Henderson, G Koster, HW Clark, AN Hunt |
Chemistry and Physics of Lipids | 2011 |
Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice
MD Tate, ER Job, AG Brooks, PC Reading |
Virology | 2011 |
Decreased expression of surfactant protein D mRNA in human lungs in fatal cases of H5N1 avian influenza
A Kongchanagul, O Suptawiwat, C Boonarkart, R Kitphati, P Puthavathana, M Uiprasertkul, P Auewarakul |
Journal of Medical Virology | 2011 |
Responses of Mouse Airway Epithelial Cells and Alveolar Macrophages to Virulent and Avirulent Strains of Influenza A Virus
MD Tate, HC Schilter, AG Brooks, PC Reading |
Viral Immunology | 2011 |
S-nitrosylation of Surfactant Protein D as a modulator of pulmonary inflammation
EN Atochina-Vasserman |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2011 |
Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1
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Biochimica et Biophysica Acta (BBA) - General Subjects | 2011 |
The Ability of Pandemic Influenza Virus Hemagglutinins to Induce Lower Respiratory Pathology is Associated with Decreased Surfactant Protein D Binding
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Virology | 2011 |
Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro
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PloS one | 2011 |
Introduction of N -Linked Glycans in the Lectin Domain of Surfactant Protein D: IMPACT ON INTERACTIONS WITH INFLUENZA A VIRUSES
M Eijk, L Bruinsma, KL Hartshorn, MR White, MJ Rynkiewicz, BA Seaton, W Hemrika, RA Romijn, BW van Balkom, HP Haagsman |
The Journal of biological chemistry | 2011 |
Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo
EC Crouch, TO Hirche, B Shao, R Boxio, J Wartelle, R Benabid, B McDonald, J Heinecke, S Matalon, A Belaaouaj |
The Journal of biological chemistry | 2010 |
Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice
MD Tate, DL Pickett, N van Rooijen, AG Brooks, PC Reading |
Journal of virology | 2010 |
Segmental Allergen Challenge Alters Multimeric Structure and Function of Surfactant Protein D in Humans
EN Atochina-Vasserman, C Winkler, H Abramova, F Schaumann, N Krug, AJ Gow, MF Beers, JM Hohlfeld |
American journal of respiratory and critical care medicine | 2010 |
Increasing Antiviral Activity of Surfactant Protein D Trimers By Introducing Residues From Bovine Serum Collectins: Dissociation of mannan-binding and antiviral activity
KL Hartshorn, MR White, K Smith, G Sorensen, Y Kuroki, U Holmskov, J Head, EC Crouch |
Scandinavian Journal of Immunology | 2010 |
Microbial Glycobiology
T Kohler, G Xia, E Kulauzovic, A Peschel |
Microbial Glycobiology | 2010 |
Pandemic H1N1 influenza A viruses are resistant to the antiviral activities of innate immune proteins of the collectin and pentraxin superfamilies
ER Job, YM Deng, MD Tate, B Bottazzi, EC Crouch, MM Dean, A Mantovani, AG Brooks, PC Reading |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
El papel de la inmunidad innata en las infecciones gripales humanas
J Reina |
Vacunas | 2010 |
Viral aggregating and opsonizing activity in collectin trimers
KL Hartshorn, MR White, T Tecle, G Sorensen, U Holmskov, EC Crouch |
American journal of physiology. Lung cellular and molecular physiology | 2010 |
Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D
KL Hartshorn, MR White, M Rynkiewicz, G Sorensen, U Holmskov, J Head, EC Crouch |
American journal of physiology. Lung cellular and molecular physiology | 2010 |
Review: Defensins and cathelicidins in lung immunity
N Palaniyar, T Tecle, S Tripathi, KL Hartshorn |
Innate immunity | 2010 |
Insight into the Dynamic Interaction of Different Carbohydrates with Human Surfactant Protein D: Molecular Dynamics Simulations
J Zhang, Q Zheng, H Zhang |
The Journal of Physical Chemistry B | 2010 |
Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo
S Matalon, K Shrestha, M Kirk, S Waldheuser, B McDonald, K Smith, Z Gao, A Belaaouaj, EC Crouch |
The FASEB Journal | 2009 |
Interactions of α-, β-, and θ-Defensins with Influenza A Virus and Surfactant Protein D
M Doss, MR White, T Tecle, D Gantz, EC Crouch, G Jung, P Ruchala, AJ Waring, RI Lehrer, KL Hartshorn |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
Human defensins and LL-37 in mucosal immunity
M Doss, MR White, T Tecle, KL Hartshorn |
Journal of leukocyte biology | 2009 |
Multiple components contribute to ability of saliva to inhibit influenza viruses
MR White, EJ Helmerhorst, A Ligtenberg, M Karpel, T Tecle, WL Siqueira, FG Oppenheim, KL Hartshorn |
Oral Microbiology and Immunology | 2009 |
Elevated Plasma Surfactant Protein D (SP-D) Levels and a Direct Correlation with Anti-severe Acute Respiratory Syndrome Coronavirus-specific IgG Antibody in SARS Patients
YP Wu, ZH Liu, R Wei, SD Pan, NY Mao, B Chen, JJ Han, FS Zhang, U Holmskov, ZL Xia, PG de Groot, KB Reid, WB Xu, GL Sorensen |
Scandinavian Journal of Immunology | 2009 |
Enhancement of antiviral activity of collectin trimers through cross-linking and mutagenesis of the carbohydrate recognition domain
MR White, P Boland, T Tecle, D Gantz, G Sorenson, I Tornoe, U Holmskov, B McDonald, EC Crouch, KL Hartshorn |
Journal of Innate Immunity | 2009 |
Target Pattern Recognition in Innate Immunity
U Kishore |
2009 | |
Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation
A Haczku |
Journal of Allergy and Clinical Immunology | 2008 |
Innate Immunity in the Paranasal Sinuses: A Review of Nasal Host Defenses
EH Ooi, PJ Wormald, LW Tan |
American journal of rhinology | 2008 |
Review: Surfactant protein D: A lung specific biomarker in COPD?
DD Sin, PS Pahlavan, SF Man |
Therapeutic advances in respiratory disease | 2008 |
Porcine plasma ficolin binds and reduces infectivity of porcine reproductive and respiratory syndrome virus (PRRSV) in vitro
ND Keirstead, C Lee, D Yoo, AS Brooks, MA Hayes |
Antiviral Research | 2008 |
Innate sensors of influenza virus: clues to developing better intranasal vaccines
T Ichinohe, A Iwasaki, H Hasegawa |
Expert Review of Vaccines | 2008 |
Innate immunity to influenza virus: implications for future therapy
MR White, M Doss, P Boland, T Tecle, KL Hartshorn |
Expert Review of Clinical Immunology | 2008 |
Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D
KL Hartshorn, R Webby, MR White, T Tecle, C Pan, S Boucher, RJ Moreland, EC Crouch, RK Scheule |
Respiratory Research | 2008 |
Antiviral activity of the long chain pentraxin PTX3 against influenza viruses
PC Reading, S Bozza, B Gilbertson, M Tate, S Moretti, ER Job, EC Crouch, AG Brooks, LE Brown, B Bottazzi, L Romani, A Mantovani |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Multimerization of Surfactant Protein D, but Not Its Collagen Domain, Is Required for Antiviral and Opsonic Activities Related to Influenza Virus
M White, P Kingma, T Tecle, N Kacak, B Linders, J Heuser, E Crouch, K Hartshorn |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Pulmonary Surfactant Protein D Binds MD-2 through the Carbohydrate Recognition Domain
X Nie, C Nishitani, M Yamazoe, S Ariki, M Takahashi, T Shimizu, H Mitsuzawa, K Sawada, K Smith, E Crouch, H Nagae, H Takahashi, Y Kuroki |
Biochemistry | 2008 |
Pattern Recognition Molecule Mindin Promotes Intranasal Clearance of Influenza Viruses
W Jia, H Li, YW He |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Human Neutrophil Defensins Increase Neutrophil Uptake of Influenza A Virus and Bacteria and Modify Virus-Induced Respiratory Burst Responses
T Tecle, MR White, D Gantz, EC Crouch, KL Hartshorn |
Journal of immunology (Baltimore, Md. : 1950) | 2007 |
Virus glycosylation: role in virulence and immune interactions
DJ Vigerust, VL Shepherd |
Trends in Microbiology | 2007 |
Inhibition of hemagglutination activity of influenza A viruses by SP-A1 and SP-A2 variants expressed in CHO cells
AN Mikerov, M White, K Hartshorn, G Wang, J Floros |
Medical Microbiology and Immunology | 2007 |
Pulmonary collectins in innate immunity of the lung
Y Kuroki, M Takahashi, C Nishitani |
Cellular Microbiology | 2007 |
Inhibition of influenza viral neuraminidase activity by collectins
T Tecle, MR White, EC Crouch, KL Hartshorn |
Archives of Virology | 2007 |
Effects of surfactant protein D on growth, adhesion and epithelial invasion of intestinal Gram-negative bacteria
A Hogenkamp, MV Herías, PC Tooten, EJ Veldhuizen, HP Haagsman |
Molecular Immunology | 2007 |
Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
KL Hartshorn, MR White, T Tecle, I Tornoe, GL Sorensen, EC Crouch, U Holmskov |
Respiratory Research | 2007 |
Diesel Exhaust Enhanced Susceptibility to Influenza Infection is Associated with Decreased Surfactant Protein Expression
J Ciencewicki, K Gowdy, QT Krantz, WP Linak, L Brighton, MI Gilmour, I Jaspers |
Inhalation Toxicology | 2007 |
Impact of neutrophils on antiviral activity of human bronchoalveolar lavage fluid
MR White, T Tecle, EC Crouch, KL Hartshorn |
American journal of physiology. Lung cellular and molecular physiology | 2007 |
Anti-Influenza A Virus Activities of Mannan-Binding Lectins and Bovine Conglutinin
T KAWAI, T KASE, Y SUZUKI, S EDA, T SAKAMOTO, K OHTANI, N WAKAMIYA |
Journal of Veterinary Medical Science | 2007 |
Current Topics in Innate Immunity
JD Lambris |
2007 | |
Innate Defense against Influenza A Virus: Activity of Human Neutrophil Defensins and Interactions of Defensins with Surfactant Protein D
KL Hartshorn, MR White, T Tecle, U Holmskov, EC Crouch |
Journal of immunology (Baltimore, Md. : 1950) | 2006 |
Search for additional influenza virus to cell interactions
EM Rapoport, LV Mochalova, HJ Gabius, J Romanova, NV Bovin |
Glycoconjugate Journal | 2006 |
Surfactant proteins SP-A and SP-D: Structure, function and receptors
U Kishore, TJ Greenhough, P Waters, AK Shrive, R Ghai, MF Kamran, AL Bernal, KB Reid, T Madan, T Chakraborty |
Molecular Immunology | 2006 |
Influenza A Viruses Upregulate Neutrophil Toll-Like Receptor 2 Expression and Function
RM Lee, MR White, KL Hartshorn |
Scandinavian Journal of Immunology | 2006 |
Characterization and expression sites of newly identified chicken collectins
A Hogenkamp, M Eijk, A Dijk, AJ van Asten, EJ Veldhuizen, HP Haagsman |
Molecular Immunology | 2006 |
Correction of Pulmonary Abnormalities in Sftpd-/- Mice Requires the Collagenous Domain of Surfactant Protein D
PS Kingma, L Zhang, M Ikegami, K Hartshorn, FX McCormack, JA Whitsett |
The Journal of biological chemistry | 2006 |
Effect of Lung Surfactant Collectins on Bronchoalveolar Macrophage Interaction with Blastomyces dermatitidis : Inhibition of Tumor Necrosis Factor Alpha Production by Surfactant Protein D
M Lekkala, AM LeVine, MJ Linke, EC Crouch, B Linders, E Brummer, DA Stevens |
Infection and immunity | 2006 |
Human Pulmonary Surfactant Protein D Binds the Extracellular Domains of Toll-like Receptors 2 and 4 through the Carbohydrate Recognition Domain by a Mechanism Different from Its Binding to Phosphatidylinositol and Lipopolysaccharide
M Ohya, C Nishitani, H Sano, C Yamada, H Mitsuzawa, T Shimizu, T Saito, K Smith, E Crouch, Y Kuroki |
Biochemistry | 2006 |
A Common Polymorphism in the SFTPD Gene Influences Assembly, Function, and Concentration of Surfactant Protein D
R Leth-Larsen, P Garred, H Jensenius, J Meschi, K Hartshorn, J Madsen, I Tornoe, HO Madsen, G Sørensen, E Crouch, U Holmskov |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
Variations in Helicobacter pylori Lipopolysaccharide To Evade the Innate Immune Component Surfactant Protein D
W Khamri, AP Moran, ML Worku, QN Karim, MM Walker, H Annuk, JA Ferris, BJ Appelmelk, P Eggleton, KB Reid, MR Thursz |
Infection and immunity | 2005 |
Noncapsulated Klebsiella pneumoniae bearing mannose-containing O antigens is rapidly eradicated from mouse lung and triggers cytokine production by macrophages following opsonization with surfactant protein D
E Kostina, I Ofek, E Crouch, R Friedman, L Sirota, G Klinger, H Sahly, Y Keisari |
Infection and immunity | 2005 |
Novel strategies for prevention and treatment of influenza
R Kandel, KL Hartshorn |
Expert Opinion on Therapeutic Targets | 2005 |
Innate immune response to adenovirus
Shoab A Nazir, Jordan P Metcalf |
Journal of Investigative Medicine | 2005 |
Role of surfactant protein D (SP-D) in innate immunity in the gastric mucosa: evidence of interaction with Helicobacter pylori lipopolysaccharide
AP Moran, W Khamri, MM Walker, MR Thursz |
Journal of Endotoxin Research | 2005 |
Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus
MR White, E Crouch, J Vesona, PJ Tacken, JJ Batenburg, R Leth-Larsen, U Holmskov, KL Hartshorn |
American journal of physiology. Lung cellular and molecular physiology | 2005 |
Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor
MR White, E Crouch, M Eijk, M Hartshorn, L Pemberton, I Tornoe, U Holmskov, KL Hartshorn |
American journal of physiology. Lung cellular and molecular physiology | 2005 |
Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication
J Meschi, EC Crouch, P Skolnik, K Yahya, U Holmskov, R Leth-Larsen, I Tornoe, T Tecle, MR White, KL Hartshorn |
Journal of General Virology | 2005 |
Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation
KL Hartshorn, A Ligtenberg, MR White, M van Eijk, M Hartshorn, L Pemberton, U Holmskov, E Crouch |
Biochemical Journal | 2005 |
Effective targeting of pathogens to neutrophils via chimeric surfactant protein D/anti-CD89 protein
PJ Tacken, KL Hartshorn, MR White, C Kooten, JG van de Winkel, KB Reid, JJ Batenburg |
Journal of immunology (Baltimore, Md. : 1950) | 2004 |
Pulmonary Collectins Modulate Strain-Specific Influenza A Virus Infection and Host Responses
S Hawgood, C Brown, J Edmondson, A Stumbaugh, L Allen, J Goerke, H Clark, F Poulain |
Journal of virology | 2004 |
Collectins
JK van de Wetering, LM van Golde, JJ Batenburg |
European Journal of Biochemistry | 2004 |
Interactions of Influenza A Virus with Sialic Acids Present on Porcine Surfactant Protein D
M Eijk, MR White, JJ Batenburg, AB Vaandrager, LM van Golde, HP Haagsman, KL Hartshorn |
American journal of respiratory cell and molecular biology | 2004 |
Degradation of Pulmonary Surfactant Protein D by Pseudomonas aeruginosa Elastase Abrogates Innate Immune Function
JF Alcorn, JR Wright |
The Journal of biological chemistry | 2004 |
The Innate Immune Response to Infection
SH Kaufmann, R Medzhitov, S Gordon |
2004 | |
Lupus-Prone Mice Have an Abnormal Response to Thioglycolate and an Impaired Clearance of Apoptotic Cells
PK Potter, J Cortes-Hernandez, P Quartier, M Botto, MJ Walport |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
The Cochrane Database of Systematic Reviews
L Hooper, C Bartlett, SG Davey, S Ebrahim |
The Cochrane Database of Systematic Reviews | 2003 |
Surfactant protein D (SP-D) serum levels in patients with community-acquired pneumonia☆☆This work was supported by the Danish Medical Research Council, an EU grant, contract number: QLK2-CT-2000-0035; the Novo Nordisk Foundation; Fonden til Lægevidenskabens Fremme; Ingemann O. Bucks Foundation and the Benzon Foundation
R Leth-Larsen, C Nordenbaek, I Tornoe, V Moeller, A Schlosser, C Koch, B Teisner, P Junker, U Holmskov |
Clinical Immunology | 2003 |
Surfactant protein D-mediated aggregation of Pneumocystis carinii impairs phagocytosis by alveolar macrophages
SJ Yong, Z Vuk-Pavlovic, JE Standing, EC Crouch, AH Limper |
Infection and immunity | 2003 |
Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses
KL Hartshorn, MR White, T Mogues, T Ligtenberg, E Crouch, U Holmskov |
American journal of physiology. Lung cellular and molecular physiology | 2003 |
The Macrophage as Therapeutic Target
S Gordon |
2003 | |
Lupus-Prone Mice Have an Abnormal Response to Thioglycolate and an Impaired Clearance of Apoptotic Cells
PK Potter, J Cortes-Hernandez, P Quartier, M Botto, MJ Walport |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Porcine Pulmonary Collectins Show Distinct Interactions with Influenza A Viruses: Role of the N -Linked Oligosaccharides in the Carbohydrate Recognition Domain
M van Eijk, MR White, EC Crouch, JJ Batenburg, AB Vaandrager, LM van Golde, HP Haagsman, KL Hartshorn |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
Molecular Cloning of Mouse Collectin Liver 1
T KAWAI, Y SUZUKI, S EDA, T KASE, K OHTANI, Y SAKAI, H KESHI, A FUKUOH, T SAKAMOTO, M NOZAKI, NG COPELAND, NA JENKINS, N WAKAMIYA |
Bioscience, Biotechnology, and Biochemistry | 2002 |
Contributions of the N- and C-terminal domains of surfactant protein d to the binding, aggregation, and phagocytic uptake of bacteria
KL Hartshorn, MR White, EC Crouch |
Infection and immunity | 2002 |
Distinctive anti-influenza properties of recombinant collectin 43
KL Hartshorn, U Holmskov, S Hansen, P Zhang, J Meschi, T Mogues, MR White, EC Crouch |
Biochemical Journal | 2002 |
Surfactant protein-A--deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus
G Li, J Siddiqui, M Hendry, J Akiyama, J Edmondson, C Brown, L Allen, S Levitt, F Poulain, S Hawgood |
American journal of respiratory cell and molecular biology | 2002 |
Distinct Roles for Lung Collectins in Pulmonary Host Defense
VL Shepherd |
American journal of respiratory cell and molecular biology | 2002 |
Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection
AM LeVine, K Hartshorn, J Elliott, J Whitsett, T Korfhagen |
American journal of physiology. Lung cellular and molecular physiology | 2002 |
Human Surfactant Protein D (SP-D) Binds Mycoplasma pneumoniae by High Affinity Interactions with Lipids
H Chiba, S Pattanajitvilai, AJ Evans, RJ Harbeck, DR Voelker |
The Journal of biological chemistry | 2002 |
Complementation of Pulmonary Abnormalities in SP-D(−/−) Mice with an SP-D/Conglutinin Fusion Protein
L Zhang, KL Hartshorn, EC Crouch, M Ikegami, JA Whitsett |
The Journal of biological chemistry | 2002 |
Glycomicrobiology
RJ Doyle |
2002 | |
Pulmonary collectins and innate host defense of the lung
AM LeVine, JA Whitsett |
Microbes and Infection | 2001 |
The present status of exogenous surfactant for the newborn
AE Curley, HL Halliday |
Early Human Development | 2001 |
Lectins in innate host defence against influenza virus
EM Anders, PC Reading, JL Miller |
International Congress Series | 2001 |
Surfactant proteins a and d and pulmonary host defense
JC Clark, SE Wert, CJ Bachurski, MT Stahlman, BR Stripp, TE Weaver, JA Whitsett |
Annual Review of Physiology | 2001 |
Surfactant protein D enhances clearance of influenza A virus from the lung in vivo
AM LeVine, JA Whitsett, KL Hartshorn, EC Crouch, TR Korfhagen |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
Surfactant proteins a and d and pulmonary host defense
JC Clark, SE Wert, CJ Bachurski, MT Stahlman, BR Stripp, TE Weaver, JA Whitsett |
Annual Review of Physiology | 2001 |
Carbohydrate Recognition Domain of Surfactant Protein D Mediates Interactions with Pneumocystis carinii Glycoprotein A
Z Vuk-Pavlovic, JE Standing, EC Crouch, AH Limper |
American journal of respiratory cell and molecular biology | 2001 |
Alveolar Macrophages, Surfactant Lipids, and Surfactant Protein B Regulate the Induction of Immune Responses via the Airways
JF van Iwaarden, E Claassen, SH Jeurissen, HP Haagsman, G Kraal |
American journal of respiratory cell and molecular biology | 2001 |
Localization and Functions of SP-A and SP-D at Mucosal Surfaces
BA van Rozendaal, LM van Golde, HP Haagsman |
Pediatric Pathology & Molecular Medicine | 2001 |
The Membrane-type Collectin CL-P1 Is a Scavenger Receptor on Vascular Endothelial Cells
K Ohtani, Y Suzuki, S Eda, T Kawai, T Kase, H Keshi, Y Sakai, A Fukuoh, T Sakamoto, H Itabe, T Suzutani, M Ogasawara, I Yoshida, N Wakamiya |
The Journal of biological chemistry | 2001 |
Activity of Pulmonary Surfactant Protein-D (SP-D) in Vivo Is Dependent on Oligomeric Structure
L Zhang, M Ikegami, EC Crouch, TR Korfhagen, JA Whitsett |
The Journal of biological chemistry | 2001 |
Molecular Biology of Acute Lung Injury
HR Wong, TP Shanley |
2001 | |
Prophylaxis and Treatment of Influenza Virus Infection:
R Kandel, KL Hartshorn |
BioDrugs | 2001 |
Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis
PL Shah, D Hansell, PR Lawson, KB Reid, C Morgan |
Thorax | 2000 |
Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity
KL Hartshorn, MR White, DR Voelker, J Coburn, K Zaner, EC Crouch |
Biochemical Journal | 2000 |
Collectins and collectin receptors in innate immunity
UL Holmskov |
APMIS | 2000 |
Pulmonary surfactant in innate immunity and the pathogenesis of tuberculosis
JS Ferguson, LS Schlesinger |
Tubercle and Lung Disease | 2000 |
Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera
MR White, E Crouch, D Chang, K Sastry, N Guo, G Engelich, K Takahashi, RA Ezekowitz, KL Hartshorn |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Surfactant protein-D and pulmonary host defense
EC Crouch |
Respiratory Research | 2000 |
Surfactant treatment impairs gas exchange in a canine model of acute lung injury:
JB Waugh, TB Holt, LE Olson, JE Gadek, TL Clanton |
Critical Care Medicine | 2000 |
Localization of Lung Surfactant Protein D on Mucosal Surfaces in Human Tissues
J Madsen, A Kliem, I Tornøe, K Skjødt, C Koch, U Holmskov |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Porcine Lung Surfactant Protein D: Complementary DNA Cloning, Chromosomal Localization, and Tissue Distribution
M van Eijk, HP Haagsman, T Skinner, A Archibold, KB Reid, PR Lawson |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
Aerosolized endotoxin is immediately bound by pulmonary surfactant protein D in vivo
BA van Rozendaal, CH van de Lest, M Eijk, LM van Golde, WF Voorhout, HP van Helden, HP Haagsman |
Biochimica et Biophysica Acta | 1999 |
Chronic Lung Disease in Early Infancy
D Riley |
Chronic Lung Disease in Early Infancy | 1999 |
Surfactant Protein D Stimulates Phagocytosis of Pseudomonas aeruginosa by Alveolar Macrophages
CI Restrepo, Q Dong, J Savov, WI Mariencheck, JR Wright |
American journal of respiratory cell and molecular biology | 1999 |
Surfactant Protein Levels in Severe Respiratory Syncytial Virus Infection
MH Kerr, JY Paton |
American journal of respiratory and critical care medicine | 1999 |
Brief Exposure to 95% Oxygen Alters Surfactant Protein D and mRNA in Adult Rat Alveolar and Bronchiolar Epithelium
AO Aderibigbe, RF Thomas, RR Mercer, RL Auten |
American journal of respiratory cell and molecular biology | 1999 |
Recombinant SP-D carbohydrate recognition domain is a chemoattractant for human neutrophils
GZ Cai, GL Griffin, R M., WJ Longmore, MA Moxley |
American journal of physiology. Lung cellular and molecular physiology | 1999 |
Molecular Cloning of a Novel Human Collectin from Liver (CL-L1)
K Ohtani, Y Suzuki, S Eda, T Kawai, T Kase, H Yamazaki, T Shimada, H Keshi, Y Sakai, A Fukuoh, T Sakamoto, N Wakamiya |
The Journal of biological chemistry | 1999 |
Effects of endotoxin on surfactant protein A and D stimulation of NO production by alveolar macrophages
JR Wright, DF Zlogar, JC Taylor, TM Zlogar, CI Restrepo |
American journal of physiology. Lung cellular and molecular physiology | 1999 |
Influenza A Virus Accelerates Neutrophil Apoptosis and Markedly Potentiates Apoptotic Effects of Bacteria
ML Colamussi, MR White, E Crouch, KL Hartshorn |
Blood | 1999 |
Binding of Rat and Human Surfactant Proteins A and D to Aspergillus fumigatus Conidia
TR Kozel, MJ Allen, R Harbeck, B Smith, DR Voelker, RJ Mason |
Infection and immunity | 1999 |
Increased susceptibility of diabetic mice to influenza virus infection: compromise of collectin-mediated host defense of the lung by glucose?
PC Reading, J Allison, EC Crouch, EM Anders |
Journal of virology | 1998 |
Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D
C Botas, F Poulain, J Akiyama, C Brown, L Allen, J Goerke, J Clements, E Carlson, AM Gillespie, C Epstein, S Hawgood |
Proceedings of the National Academy of Sciences | 1998 |
Functional Roles of the Lung Surfactant Proteins SP-A and SP-D in Innate Immunity
KB Reid |
Immunobiology | 1998 |
Recombinant rat surfactant-associated protein D inhibits human T lymphocyte proliferation and IL-2 production
T Madan, U Kishore, A Shah, P Eggleton, P Strong, JY Wang, SS Aggrawal, PU Sarma, KB Reid |
Journal of immunology (Baltimore, Md. : 1950) | 1998 |
Interactions of surfactant protein D with pathogens, allergens and phagocytes
KB Reid |
Biochimica et Biophysica Acta | 1998 |
Recombinant rat surfactant-associated protein D inhibits human T lymphocyte proliferation and IL-2 production
T Madan, U Kishore, A Shah, P Eggleton, P Strong, JY Wang, SS Aggrawal, PU Sarma, KB Reid |
Journal of immunology (Baltimore, Md. : 1950) | 1998 |
Collectins and Pulmonary Host Defense
EC Crouch |
American journal of respiratory cell and molecular biology | 1998 |
Interactions of surfactant protein A with pathogens
H P Haagsman |
Biochimica et Biophysica Acta | 1998 |
Structure, biologic properties, and expression of surfactant protein D (SP-D)
E C Crouch |
Biochimica et Biophysica Acta | 1998 |
Surfactant protein A and surfactant protein D in health and disease
RJ Mason, K Greene, DR Voelker |
American journal of physiology. Lung cellular and molecular physiology | 1998 |
Analysis of Chimeric Proteins Identifies the Regions in the Carbohydrate Recognition Domains of Rat Lung Collectins That Are Essential for Interactions with Phospholipids, Glycolipids, and Alveolar Type II Cells
H Sano, Y Kuroki, T Honma, Y Ogasawara, H Sohma, DR Voelker, T Akino |
The Journal of biological chemistry | 1998 |
Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria
KL Hartshorn, E Crouch, MR White, ML Colamussi, A Kakkanatt, B Tauber, V Shepherd, KN Sastry |
American journal of physiology. Lung cellular and molecular physiology | 1998 |
Degradation of surfactant protein D by alveolar macrophages
Q Dong, JR Wright |
American journal of physiology. Lung cellular and molecular physiology | 1998 |
Principles of Perinatal—Neonatal Metabolism
RM Cowett |
1998 | |
Molecular Structures and Interactions of Pulmonary Surfactant Components
J Johansson, T Curstedt |
European Journal of Biochemistry | 1997 |
Surfactant protein A, but not surfactant protein D, is an opsonin for influenza A virus phagocytosis by rat alveolar macrophages
CA Benne, B Benaissa-Trouw, JA van Strijp, CA Kraaijeveld, JF van Iwaarden |
European Journal of Immunology | 1997 |
Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages
T Madan, P Eggleton, U Kishore, P Strong, SS Aggrawal, PU Sarma, KB Reid |
Infection and immunity | 1997 |
Structure of a truncated human surfactant protein D is less effective in agglutinating bacteria than the native structure and fails to inhibit haemagglutination by influenza A virus
S Eda, Y Suzuki, T Kawai, K Ohtani, T Kase, Y Fujinaga, T Sakamoto, T Kurimura, N Wakamiya |
Biochemical Journal | 1997 |
Enzyme-linked immunosorbent assay using F(ab′)2 fragment for the detection of human pulmonary surfactant protein D in sera
H Nagae, H Takahashi, Y Kuroki, Y Honda, A Nagata, Y Ogasawara, S Abe, T Akino |
Clinica Chimica Acta | 1997 |
Isolation and Characterization of a New Member of the Scavenger Receptor Superfamily, Glycoprotein-340 (gp-340), as a Lung Surfactant Protein-D Binding Molecule
U Holmskov, P Lawson, B Teisner, I Tornøe, AC Willis, C Morgan, C Koch, KB Reid |
The Journal of biological chemistry | 1997 |
Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins
KL Hartshorn, MR White, V Shepherd, K Reid, JC Jensenius, EC Crouch |
American journal of physiology. Lung cellular and molecular physiology | 1997 |
Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice
PC Reading, LS Morey, EC Crouch, EM Anders |
Journal of virology | 1997 |
Toxic oxidant species and their impact on the pulmonary surfactant system
E Putman, LM van Golde, HP Haagsman |
Lung | 1997 |
Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice.
Reading PC, Morey LS, Crouch EC, Anders EM |
Journal of virology | 1997 |
Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages.
Madan T, Eggleton P, Kishore U, Strong P, Aggrawal SS, Sarma PU, Reid KB |
Infection and immunity | 1997 |
The collectins in innate immunity
J Epstein, Q Eichbaum, S Sheriff, RA Ezekowitz |
Current Opinion in Immunology | 1996 |
Recombinant bovine conglutinin, lacking the N-terminal and collagenous domains, has less conglutination activity but is able to inhibit haemagglutination by influenza A virus
S Eda, Y Suzuki, T Kase, T Kawai, K Ohtani, T Sakamoto, T Kurimura, N Wakamiya |
Biochemical Journal | 1996 |
Localization and Developmental Expression of Surfactant Proteins D and A in the Respiratory Tract of the Mouse
CJ Wong, J Akiyama, L Allen, S Hawgood |
Pediatric Research | 1996 |
Characterization of Radioiodinated Lung Surfactant Protein a (SP-A) and the Effects of Oxidation on SP-A Quaternary Structure and Activity
GR Stuart, RB Sim, R Malhotra |
Experimental Lung Research | 1996 |
Site-directed Mutagenesis of Cys-15 and Cys-20 of Pulmonary Surfactant Protein D: EXPRESSION OF A TRIMERIC PROTEIN WITH ALTERED ANTI-VIRAL PROPERTIES
P Brown-Augsburger, K Hartshorn, D Chang, K Rust, C Fliszar, HG Welgus, EC Crouch |
The Journal of biological chemistry | 1996 |
Biosynthesis of Surfactant Protein D: CONTRIBUTIONS OF CONSERVED NH 2 -TERMINAL CYSTEINE RESIDUES AND COLLAGEN HELIX FORMATION TO ASSEMBLY AND SECRETION
P Brown-Augsburger, D Chang, K Rust, EC Crouch |
The Journal of biological chemistry | 1996 |
In VitroandIn VivoTransfer and Expression of Human Surfactant SP-A- and SP-B-Associated Protein cDNAs Mediated by Replication-Deficient, Recombinant Adenoviral Vectors
RJ Korst, B Bewig, RG Crystal |
Human Gene Therapy | 1995 |
Collectins and viral infection
R Malhotra, RB Sim |
Trends in Microbiology | 1995 |
Binding of host collectins to the pathogenic yeast Cryptococcus neoformans: human surfactant protein D acts as an agglutinin for acapsular yeast cells
S Schelenz, R Malhotra, RB Sim, U Holmskov, GJ Bancroft |
Infection and immunity | 1995 |
The Role of the Amino-terminal Domain and the Collagenous Region in the Structure and the Function of Rat Surfactant Protein D
Y Ogasawara, DR Voelker |
The Journal of biological chemistry | 1995 |
Altered Carbohydrate Recognition Specificity Engineered into Surfactant Protein D Reveals Different Binding Mechanisms for Phosphatidylinositol and Glucosylceramide
Y Ogasawara, DR Voelker |
The Journal of biological chemistry | 1995 |